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Conserved domains on  [gi|21312840|ref|NP_080599|]
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WAP four-disulfide core domain protein 2 isoform 1 precursor [Mus musculus]

Protein Classification

WAP domain-containing protein( domain architecture ID 10442829)

WAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 127-173 2.04e-09

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


:

Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 2.04e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 21312840 127 EKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 173
Cdd:cd00199  15 EKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCG-KSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-73 5.65e-07

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 44.34  E-value: 5.65e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21312840    32 KPGECPQLEPITDCVLECTLDKDCADNRKCCQAGCSSVCSKP 73
Cdd:pfam00095   1 KPGCCPRLGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 127-173 2.04e-09

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 2.04e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 21312840 127 EKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 173
Cdd:cd00199  15 EKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCG-KSCLTPV 60
WAP smart00217
Four-disulfide core domains;
128-173 2.80e-07

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 45.05  E-value: 2.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 21312840    128 KQGTCPSVDI--PKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 173
Cdd:smart00217   1 KPGSCPWPTIasCPLGNPPNKCSSDSQCPGVKKCCFNGCG-KSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-73 5.65e-07

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 44.34  E-value: 5.65e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21312840    32 KPGECPQLEPITDCVLECTLDKDCADNRKCCQAGCSSVCSKP 73
Cdd:pfam00095   1 KPGCCPRLGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 128-172 8.74e-06

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 40.87  E-value: 8.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 21312840   128 KQGTCPSVdiPKLGLCEDQCQVDSQCSGNMKCCRNGCGKMaCTTP 172
Cdd:pfam00095   1 KPGCCPRL--GARGCCRSCCSSDDDCPGRQKCCSNGCGSV-CVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 127-173 2.04e-09

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 51.30  E-value: 2.04e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 21312840 127 EKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 173
Cdd:cd00199  15 EKPGRCPMVNPPSLGIPPNRCSSDSDCPGDKKCCENGCG-KSCLTPV 60
WAP smart00217
Four-disulfide core domains;
128-173 2.80e-07

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 45.05  E-value: 2.80e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 21312840    128 KQGTCPSVDI--PKLGLCEDQCQVDSQCSGNMKCCRNGCGkMACTTPK 173
Cdd:smart00217   1 KPGSCPWPTIasCPLGNPPNKCSSDSQCPGVKKCCFNGCG-KSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 32-73 5.65e-07

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 44.34  E-value: 5.65e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 21312840    32 KPGECPQLEPITDCVLECTLDKDCADNRKCCQAGCSSVCSKP 73
Cdd:pfam00095   1 KPGCCPRLGARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 128-172 8.74e-06

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 40.87  E-value: 8.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 21312840   128 KQGTCPSVdiPKLGLCEDQCQVDSQCSGNMKCCRNGCGKMaCTTP 172
Cdd:pfam00095   1 KPGCCPRL--GARGCCRSCCSSDDDCPGRQKCCSNGCGSV-CVPP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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