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Conserved domains on  [gi|14389303|ref|NP_113725|]
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protein RoBo-1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 123-181 1.97e-10

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467102  Cd Length: 80  Bit Score: 55.51  E-value: 1.97e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14389303 123 NGVECPTCYSEL-GTCRPV-SLKCTGAQTTCVNVTGQGIREDFIKIHAM-GCATQTACNLKN 181
Cdd:cd23572   1 NGLQCPACYSEGsDSCKSEeTVNCTGEETQCIEFSGTISGGGSSVKFAMkGCATESACDLGK 62
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 123-181 1.97e-10

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 55.51  E-value: 1.97e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14389303 123 NGVECPTCYSEL-GTCRPV-SLKCTGAQTTCVNVTGQGIREDFIKIHAM-GCATQTACNLKN 181
Cdd:cd23572   1 NGLQCPACYSEGsDSCKSEeTVNCTGEETQCIEFSGTISGGGSSVKFAMkGCATESACDLGK 62
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 123-181 1.97e-10

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 55.51  E-value: 1.97e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14389303 123 NGVECPTCYSEL-GTCRPV-SLKCTGAQTTCVNVTGQGIREDFIKIHAM-GCATQTACNLKN 181
Cdd:cd23572   1 NGLQCPACYSEGsDSCKSEeTVNCTGEETQCIEFSGTISGGGSSVKFAMkGCATESACDLGK 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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