|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
49-461 |
3.23e-157 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 449.75 E-value: 3.23e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVF 208
Cdd:cd17390 81 STSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 209 ILNAGLVWFFPwreakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWDI 288
Cdd:cd17390 161 ILNAGLVWFLL---------------------------------------------------------------SKLWDL 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 289 FLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLLY 368
Cdd:cd17390 178 LLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 369 SLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAVL 448
Cdd:cd17390 258 ALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVL 337
|
410
....*....|...
gi 217416366 449 ALVAIFIMSLNKR 461
Cdd:cd17390 338 ALAAILLMLARQR 350
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
49-458 |
2.40e-65 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 214.36 E-value: 2.40e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKS---LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLL 125
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREfnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 126 LGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICF 205
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP-YGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 206 LVFILNAGLVWFFPWReakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknllfseM 285
Cdd:cd17330 160 ALALLNLVLVLFFLPP---------------------------------------------------------------L 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 286 WDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlYKHNSQALLLHSSILTCTLL 365
Cdd:cd17330 177 RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLA-KRLGERKLLRLGLLLAIIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 366 LLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSL 444
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLySFLGPGVPFLL 335
|
410
....*....|....
gi 217416366 445 GAVLALVAIFIMSL 458
Cdd:cd17330 336 AAGLLLIALFLLSL 349
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
45-458 |
9.47e-39 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 144.67 E-value: 9.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 45 FLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYL 124
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 125 LLGAATNVFLFVLARVPAgIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFIC 204
Cdd:cd17331 81 LLAFASSVPMLFLSRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKF-GEQAAALVA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 205 FLVFILNAGLVWFFPwreakPGSTekglplrkthvllgrshdtvQEAATSRRARASKKTAQPWVEVVLALRNMKNLlfse 284
Cdd:cd17331 159 AVGSLLSIVLVILLI-----PSNT--------------------KSKREKEAKESASPPSVFNLKEILRLLRLPGV---- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 285 mWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLyKHNSQALLLHSSILTCTL 364
Cdd:cd17331 210 -AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTK-RFGERSLLKLSVALLAIG 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 365 LLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPS 443
Cdd:cd17331 288 YLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALlQAYGFPSFGL 367
|
410
....*....|....*
gi 217416366 444 LGAVLALVAIFIMSL 458
Cdd:cd17331 368 LGAAINGLLTVYLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-458 |
3.57e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 131.93 E-value: 3.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLV 207
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 208 FILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLLGRSHDtvqeaatsrraraskktaqpwvevvlalrnmknllfSEMWD 287
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD------------------------------------RRLLA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 288 IFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPIlrLYKHNSQALLLHSSILTCTLLLL 367
Cdd:cd17325 204 LFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL--SDRIGRKPLILIGLLLSAVALLL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 368 YSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGA 446
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLAAA 361
|
410
....*....|..
gi 217416366 447 VLALVAIFIMSL 458
Cdd:cd17325 362 ALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
49-427 |
1.16e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 112.90 E-value: 1.16e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHV-KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLG 127
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 128 AATNVFLFVLARVPAGIFK-HTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYLTAFICFL 206
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL-FGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 207 VFILNAGLVWFFPwreakpgstekglplrkthvllgrshdtvqEAATSRRARASKKTAQPWVEVVLALRNMKNLLfsemw 286
Cdd:pfam07690 160 LSLLAAVLLLLPR------------------------------PPPESKRPKPAEEARLSLIVAWKALLRDPVLW----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 287 diFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-L 365
Cdd:pfam07690 205 --LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217416366 366 LLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAP 427
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
42-422 |
2.77e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.21 E-value: 2.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 42 ARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSAL 121
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 122 GYLLLGAATNVFLFVLARVPAGIFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLT 200
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF-GWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 201 AFICFLVFILNAGLVWFFpwreakpgstekglplrkthvllgrshdtVQEAATSRRARASKKTAQPWVEVVLALrnmknl 280
Cdd:COG2814 167 FLVNAVLALLALLLLLRL-----------------------------LPESRPAARARLRGSLRELLRRPRLLL------ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 281 lfsemwdIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSIL 360
Cdd:COG2814 212 -------LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217416366 361 TCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVG 422
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
49-458 |
5.19e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.42 E-value: 5.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGIFKHTLSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLV 207
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 208 FILNAGLVWFFPWREAKPGSTEKGlplrkthvllgrshdtvqeaatsrrarASKKTAQPWVEVVLALRNMKnllfseMWD 287
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKN---------------------------EEASSKSVLKLLKRVLKNPG------LWL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 288 IFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTLLLL 367
Cdd:cd06174 208 LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 368 YsLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPPSLGAV 447
Cdd:cd06174 288 L-LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVL 366
|
410
....*....|.
gi 217416366 448 LALVAIFIMSL 458
Cdd:cd06174 367 AVLLLLAAILL 377
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
82-456 |
6.07e-20 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 91.57 E-value: 6.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 82 GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVP 161
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTS 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 162 EKERPLVIGHFNTASGVGFILGPVVGGYL----TELEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGStekglpLRkt 237
Cdd:cd17389 147 PKKRSKGMALIGVAFSLGFIIGPMIGAYFasftRSLGEVFFSMPALFALVLALADLLFIFFFLPETLPSN------LR-- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 238 hvLLGRSHdtvqeaatsrraraskktaqpwvevVLALrnmknLLFSEMWdiFLVRLLMAmavmlyysnfvlaleERFgvr 317
Cdd:cd17389 219 --RLGLVY-------------------------FLYL-----FLFSGLE--FTLTFLTH---------------QRF--- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 318 pkvtgyliSYSSM--------LGAVAGLALGPILRLYKHNSQALLLHSSILTCTL-LLLYSLAPTMGAVVLSSTLLSFST 388
Cdd:cd17389 247 --------QYTSMqqgkmfffIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPaFLLIGWASSVTVLYAGLFLYSFAA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 217416366 389 AIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLL-SGVAQEVSPCGPPSLGAVLALVAIFIM 456
Cdd:cd17389 319 ATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVaCTVYWLAGSEACYTIGALLFLLPLLLL 387
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
49-455 |
1.43e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 89.94 E-value: 1.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLtAFICFLV 207
Cdd:cd17474 84 SDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI--SWRY-PFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 208 FILNAGLVWFFpwreakpgstekglplrkthvLLGRSHDTVQEAATSRRARASKKTAQPWVEVVLALRNMKNLLFsemwd 287
Cdd:cd17474 161 LIPVAFLAILF---------------------LLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY----- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 288 iFLVrllmamavmLYYSNFVlaLEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLyKHNSQALLLHSSILTCTLLLL 367
Cdd:cd17474 215 -FAF---------LTYLPFL--LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK-RFGARRILVIGLLLYALSLLL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 368 YSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPSLGA 446
Cdd:cd17474 282 LGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGlLLEIFGLSAPFLVGA 361
|
....*....
gi 217416366 447 VLALVAIFI 455
Cdd:cd17474 362 AIALAAAVL 370
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
46-456 |
4.74e-17 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 82.68 E-value: 4.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVA----GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSAL 121
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 122 GYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE--LEDGFYL 199
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEisPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 200 TAFICFLVFIlnagLVWFFpwreakpgstekglpLRKTHvllgrshdtvqeaATSRRARASKKTAQPWVEVVlALRNMKN 279
Cdd:cd17388 161 AAGLNGLNFL----LGLFV---------------LPESL-------------PPERRRAFRWRRANPFGSLR-WLTGFPG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 280 LLFsemwdIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVA-GLALGPILRlyKHNSQALLLHSS 358
Cdd:cd17388 208 LLG-----LLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAK--RLGEKRAILLGL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 359 ILTCTLLLLYSLAPTmGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSP 438
Cdd:cd17388 281 AADALGFLLLAFATQ-GWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASP 359
|
410 420
....*....|....*....|..
gi 217416366 439 CGPPSL----GAVLALVAIFIM 456
Cdd:cd17388 360 ATWPGLawiiGAALYLICLVLA 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-218 |
1.10e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.47 E-value: 1.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 14 RLVSETAERKQEQKTGTEAEAADSGAVGARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSL-GASPTVAGIVGSSYGILQ 92
Cdd:cd17325 169 LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLAS 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 93 LFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSIS-RALLSDVVPEKERPLVIGH 171
Cdd:cd17325 249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAtLALLADIVPPEGRGTAMGL 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 217416366 172 FNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFF 218
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
45-461 |
7.74e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 78.76 E-value: 7.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 45 FLLCLYLVGFLDLFGVSMVVPLLSlhvKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYL 124
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQ---ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 125 LLGAATNVFLFVLARVPAGIFKHTLSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLT 200
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAAlKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwraAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 201 AFICFLVFILNaglvwffpwreakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknl 280
Cdd:COG2271 171 GLPGLLLALLR--------------------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 281 lfseMWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSIL 360
Cdd:COG2271 182 ----FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 361 TCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCG 440
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
410 420
....*....|....*....|..
gi 217416366 441 PP-SLGAVLALVAIFIMSLNKR 461
Cdd:COG2271 338 AAfLLLAALALLAALLALLLLR 359
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
49-243 |
6.88e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.09 E-value: 6.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLV 207
Cdd:cd17489 81 ATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-GFAVLFIVAAVL 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 217416366 208 FILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLLGR 243
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK 195
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-432 |
2.70e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 74.19 E-value: 2.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHV-KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLG 127
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 128 AATNVFLFVLARVPAGIFKhTLSI--SRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLteLEDGFYLTAFICF 205
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGG-GLFEpaSEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 206 LVFILNAGLVWFfpwreakpgstekglplrkthvllgrshdTVQEAATSRRARASKKTAQPWVEVvlaLRNMKNLLFsem 285
Cdd:cd17329 161 VLFLLAALVLLF-----------------------------LLPETRPKRRAAEKTEILRGYKIV---LRDRAFLLF--- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 286 wdiFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLalgPILRLYKHNSQALLLHSSILTCTL- 364
Cdd:cd17329 206 ---LLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQF---PVARLVERFRLRKILMIGILLFAIg 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 217416366 365 LLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGV 432
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
54-236 |
9.43e-14 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 72.68 E-value: 9.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 54 FLDLFGVSMVVPLLSLHVKSLGASPTV-----AGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17391 6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICF 205
Cdd:cd17391 86 VTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGirnVFFITGGLLF 165
|
170 180 190
....*....|....*....|....*....|.
gi 217416366 206 LVFIlnagLVWFFPWREAKPGSTEKGLPLRK 236
Cdd:cd17391 166 LAFL----LTLFFVKEDFKPVEKKKMVSTKE 192
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
43-210 |
1.14e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.38 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 43 RRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALG 122
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 123 YLLLGAATNVFLFVLARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFY 198
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMpGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGwrwIFL 172
|
170
....*....|..
gi 217416366 199 LTAFICFLVFIL 210
Cdd:COG0477 173 INAPLGLLALVL 184
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-456 |
2.99e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.98 E-value: 2.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSLHVKS-LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYL 124
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 125 LLGAATNVFLFVLARVPAGIFKH-TLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEdgfYLTAFI 203
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAgIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG---WRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 204 CFLVFILNAGLVWFFPWreakpgstekglplrkthvllgrshDTVQEAATSRRARASKKTAQPWVEVVLALrnmknllfs 283
Cdd:cd17473 158 VYLLALPVLILVLLFLP-------------------------EPARKSKSAASPGAATAAALPWKRVLPIY--------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 284 emwdiflvrLLMAMAVMLYYS---NFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHnsQALLLHSSIL 360
Cdd:cd17473 204 ---------FLAFLAMLLFYVipiQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK--RRLLAIGFAL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 361 TCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG--VAQEVSP 438
Cdd:cd17473 273 MALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGplVNLTGGL 352
|
410
....*....|....*...
gi 217416366 439 CGPPSLGAVLALVAIFIM 456
Cdd:cd17473 353 SGAFLILGVLALVLAIVL 370
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-219 |
3.10e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 68.01 E-value: 3.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSL-GASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLG 127
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 128 AATNVFLFVLARVPAGIFKHTLSISrALLSDVVPEKERPLVIGH----FNTASGVGFILGPVVGGYLTeLEDGFYLTAFI 203
Cdd:cd17472 81 YATSIYGLILGRALQGSGAISSVVM-ALLADLTREENRTKAMALigasIGIAFAISMVLGPLLAAHLG-VSGLFLITAIL 158
|
170
....*....|....*.
gi 217416366 204 CFLVFILnagLVWFFP 219
Cdd:cd17472 159 SLVSLLI---LLFFVP 171
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
51-219 |
8.65e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.44 E-value: 8.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 51 LVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAAT 130
Cdd:cd17323 6 FLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 131 NVFLFVLARVPAGIFKHT-LSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFL 206
Cdd:cd17323 86 NIAMLIILRFLQGFFGSSpLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGwrwIFWFLAIISGF 165
|
170
....*....|...
gi 217416366 207 VFILnagLVWFFP 219
Cdd:cd17323 166 CLIL---IFLFLP 175
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
45-219 |
4.46e-10 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 61.87 E-value: 4.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 45 FLLCLYLvgFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVgSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYL 124
Cdd:cd06179 1 AALCLAY--FAQLFGVTLPAAVLPFIVADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 125 LLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG-----FYL 199
Cdd:cd06179 78 VAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgwrwiFYI 157
|
170 180
....*....|....*....|
gi 217416366 200 TAFICFLVFILnaGLVWFFP 219
Cdd:cd06179 158 NAIFNALALIL--LFFFYHP 175
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
49-236 |
4.72e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 61.04 E-value: 4.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGIFKHTLSI-SRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLV 207
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVvSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLL 160
|
170 180
....*....|....*....|....*....
gi 217416366 208 filnAGLVWFFPWREAKPGSTEKGLPLRK 236
Cdd:cd17477 161 ----ALVPLLLTRRAAPEIEEAESISLRR 185
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
28-458 |
8.05e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 60.66 E-value: 8.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 28 TGTEAEAADSGAVGARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVG 107
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 108 RRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIfkhTLSISRALLSDVVPE---KERPLVIGHFNTASGVGFILGP 184
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA---GIAVGNVLLPGLIKRwfpDRVGLMTGLYTAAMGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 185 VVGGYLTELEDgfYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLlgrshdtvqeaatsrraraskKTA 264
Cdd:COG2807 159 GLTVPLAAALG--WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLW---------------------RSP 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 265 QPWvevvlalrnmknllfsemwdifLVRLLMAMAVMLYYS--NFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPI 342
Cdd:COG2807 216 LAW----------------------LLTLFFGLQSLLYYAvvAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 343 LRLYKHNSQALLLhSSILTCTLLLLYSLAPTmGAVVLSSTLLSFSTAIGRT-CITDLQLTVGGAQASGTLIGVGQSVTAV 421
Cdd:COG2807 274 ADRLGDRRPLLLL-LGLLGLAGLLGLLLAPG-SLPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYL 351
|
410 420 430
....*....|....*....|....*....|....*..
gi 217416366 422 GRIIAPLLSGVAQEVSpcGPPSLGAVLALVAIFIMSL 458
Cdd:COG2807 352 LAALGPLLVGALHDAT--GSWTAALLLLAALAVLMLV 386
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
84-192 |
9.65e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 59.88 E-value: 9.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 84 VGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTL-SISRALLSDVVPE 162
Cdd:cd17502 35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPP 114
|
90 100 110
....*....|....*....|....*....|
gi 217416366 163 KERPLVIGHFNTASGVGFILGPVVGGYLTE 192
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVAGPLIGGAFTD 144
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
43-210 |
2.09e-09 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 59.16 E-value: 2.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 43 RRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVA-----GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACIL 117
Cdd:PRK09874 13 KRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 118 LSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LE 194
Cdd:PRK09874 93 GMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADsygLR 172
|
170
....*....|....*.
gi 217416366 195 DGFYLTAFICFLVFIL 210
Cdd:PRK09874 173 PVFFITASVLFLCFLV 188
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
62-456 |
2.74e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 58.71 E-value: 2.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 62 MVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVP 141
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 142 AGIFkHTL--SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFICFLVFILNAGLVWFFP 219
Cdd:cd17324 97 AGLA-HGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 220 wreakpgstekglplrkthvllgrshdtvqeaatsrRARASKKTAQPWVEVVLALRNMKNLLFsemwdIFLVRLLMAMAV 299
Cdd:cd17324 176 ------------------------------------SLPPKKPGSLGLLSSLLLLLRNPRLRL-----AYLITFLLFGGF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 300 MLYYSNFVLALEERFGVRPKVTGYLIsyssMLGAVAGLALGPIL-RLYKHNS-QALLLHSSILTCTLLLLYSLAPTMGAV 377
Cdd:cd17324 215 FALYTYLAPFLTDVPGFSSSAIIGLL----LLFGVAGVVGSPLAgRLADRGGrRALLIALLLLAAALLLLTLLGPSPLLL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 378 VLSSTLLSFSTAIGRTCitdLQLTVG--GAQASGTLIGVGQSVTAVGRIIAPLLSGVA-QEVSPCGPPSLGAVLALVAIF 454
Cdd:cd17324 291 LVGLVLWGLGFFAAHSA---LQTRVLrlAPEARGLASSLYLAAYNLGGALGAALGGLVlDHGGWAGVGWVGAALLLLALL 367
|
..
gi 217416366 455 IM 456
Cdd:cd17324 368 LA 369
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
21-218 |
2.81e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.71 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 21 ERKQEQKTGTEAEAADSGAVGARRFLLCLYLVGFLDLFGVSMvvPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVG 100
Cdd:cd17370 178 KEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSF--AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAG 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 101 CWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKH-TLSISRALLSDVVPEKERPLVIGHFNTASGVG 179
Cdd:cd17370 256 RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGaQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335
|
170 180 190
....*....|....*....|....*....|....*....
gi 217416366 180 FILGPVVGGYLTELEdgFYLTAFIcFLVFILNAGLVWFF 218
Cdd:cd17370 336 WLLASLIAGYLWDLI--SPSAAFL-FSAVLALIALLLLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
43-462 |
4.11e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.33 E-value: 4.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 43 RRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALG 122
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 123 YLLLGAATNVFLFVLARVPAGIFKHTLSIS-RALLSDVVPEKERPLvIGHFNTASGVGFILGPVVGGYLTELEDGFYLTA 201
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAaNPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 202 --FICFLVFILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLLGRSHdtvqeaatsrraraskktaqpwvevvlalrnmkn 279
Cdd:COG0738 166 pyLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPR---------------------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 280 llfseMWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRlyKHNSQALLLHSSI 359
Cdd:COG0738 212 -----LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK--RFGPVRLLRLSAL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 360 LTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAqASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSP 438
Cdd:COG0738 285 LAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGfLADAFGL 363
|
410 420
....*....|....*....|....
gi 217416366 439 CGPPSLGAVLALVAIFIMSLNKRH 462
Cdd:COG0738 364 RAAFLVPLVCYLLILLLALALKRK 387
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
50-461 |
4.42e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.35 E-value: 4.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 50 YLVGFLDLFGVSMVVPLLSlhvKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAA 129
Cdd:COG2223 14 FFLAFGVWYLWSVLAPPLA---EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 130 TNVFLFVLARVPAGI-----FkhtlSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLteLEDGFYLTAFIC 204
Cdd:COG2223 91 VSYWLLLLLGLLLGIggggsF----AVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--IAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 205 FLVFILNAGLVWFFPWREAKPGSTEKglplrkthvllgrshdtvqEAATSRRARASKKTAQPWVevvlalrnmknllfse 284
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAA-------------------AKASLRDQLEALRDPRFWL---------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 285 mwdIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPIL-RLYKHNSQALLLhsSILTCT 363
Cdd:COG2223 210 ---LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSdRIGGRRVLLIVF--ALMALG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 364 LLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSpcGPPS 443
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT--GSYT 362
|
410 420
....*....|....*....|..
gi 217416366 444 LG----AVLALVAIFIMSLNKR 461
Cdd:COG2223 363 AAflvfAVLALVALVLTLLLYR 384
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
49-456 |
4.43e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 58.00 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLL-ACILLSALGYLLLG 127
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 128 AATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LEDGFYLTAFIC 204
Cdd:cd17490 81 LFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEhfgMRAPFLLAALAG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 205 FLVFILNAGLvwffpwreaKPGSTEKglplrkthvllgrshdtvqeaatsrrarasKKTAQPWVEVVLALRNMKNLLFSE 284
Cdd:cd17490 161 VLGFILSLFI---------KEERREK------------------------------KPVLTELKELLSVLKDKKLLFFSL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 285 MwdiFLVRLLMAMAVMLYYSNfvLALEERFGVRPKVTgyLISYSSMLGAVAGLALGPILRLYKHNSQALLLHSSILTCTL 364
Cdd:cd17490 202 L---AILQQMITFSTTFGFTP--LIAKQLGASSFQLG--LLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAY 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 365 LLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG-VAQEVSPCGPPS 443
Cdd:cd17490 275 CFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGiISEAFGLQTGFF 354
|
410
....*....|...
gi 217416366 444 LGAVLALVAIFIM 456
Cdd:cd17490 355 VIGVIALLAAILS 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-210 |
1.11e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 51 LVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSY----GILQLFSSTLvgcwSDVVGRRSSLLACILLSALGYLLL 126
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYllafAALLLLAGRL----GDRFGRKRVFLIGLALFGLASLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 127 GAATNVFLFVLARVPAGIFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAF 202
Cdd:cd17321 79 ALAPSLAFLIAARALQGIGAAAImPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGwrwIFLINVP 158
|
....*...
gi 217416366 203 ICFLVFIL 210
Cdd:cd17321 159 IGLVALLL 166
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
49-210 |
5.55e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.51 E-value: 5.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGA 128
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 129 ATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL---EDGFYLTAFICF 205
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHlgwRWIFWTAAPVAV 160
|
....*
gi 217416366 206 LVFIL 210
Cdd:cd17504 161 LLAAL 165
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-231 |
1.10e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.78 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSlhvKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLL 125
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQ---SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 126 LGAATNVFLFVLARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG----FYLT 200
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGwrwaFRVT 160
|
170 180 190
....*....|....*....|....*....|.
gi 217416366 201 AficfLVFILNAGLVWFFPwREAKPGSTEKG 231
Cdd:cd17328 161 G----VLGVLLAILLLLFV-REPPRGAAEGG 186
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
45-455 |
2.13e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.96 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 45 FLLCLYLVGFLDLFGVSMVVPLLSlhvKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYL 124
Cdd:cd17319 7 LLFLAYVINYLDRVNISVAAPTIM---KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 125 LLGAATNVFLFVLARVPAGIFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFI 203
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAEAGFfPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 204 CFLVFILnaGLVWFFpwreakpgstekglplrkthvllgrshdtvqeaatsrraraskktaqpwvevvlalrnmknlLFS 283
Cdd:cd17319 164 GLLGLLL--AVLWWF--------------------------------------------------------------YLR 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 284 EMWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPIL-RLYKHNSQALLLHSSILTC 362
Cdd:cd17319 180 QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSdRLLRGARRLVIIIGLLLAA 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 363 TLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSG--VAQEVSPCG 440
Cdd:cd17319 260 VGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGylVDATGSYTA 339
|
410
....*....|....*
gi 217416366 441 PPSLGAVLALVAIFI 455
Cdd:cd17319 340 AFLFLAAVALLAALL 354
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
46-219 |
2.31e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.58 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSY----GILQLFsstlVGCWSDVVGRRSSLLACILLSAL 121
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYllgfALGQLL----YGPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 122 GYLLLGAATNVFLFVLARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLT 200
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF 156
|
170
....*....|....*....
gi 217416366 201 AFICFLVFILNAGLVWFFP 219
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLP 175
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
47-458 |
2.91e-07 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 52.59 E-value: 2.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 47 LCLYLVGFLDLFGVSMvvPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLAC--ILLSALGYL 124
Cdd:cd17335 2 LKLFYFFFFAALGSLL--PFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLslLAAVLFFLS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 125 LLGAATNVFLFVLARVPAGIFKH-TLSISRALLSDVVpeKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGF--YLTA 201
Cdd:cd17335 80 LFFVAQIFWLLLLLVILGAFFSApVVPLVDSITLQYL--GEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYknYTIA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 202 FICFLVF-ILNAGLVWFFPWREAKPGSTEKGLPLRKthvllgrshdtvqeaatsrraraskktaqpwvevvlALRNMKNL 280
Cdd:cd17335 158 FYVFAVLmLLALLLALKFPFRPKHPEPNENTGGLLA------------------------------------LLRNPRVL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 281 LFsemwdiFLVRLLMAMAVMLYYSNFVLALEERFGvrpkvTGYLISYSSMLGAVAGLAL----GPILRLYKHNsqaLLLH 356
Cdd:cd17335 202 AF------LLVAFLMGFGHGLIYSFLFWHLQDLGG-----SKTLIGLLWTVGVVSEIPFfffsSRLIQRFGHV---GLLY 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 357 SSILTCTL-LLLYSLAPTMGAVVLSSTL--LSFSTAIGrTCITDLQLTVgGAQASGTLIGVGQSVTA-VGRIIAPLLSGV 432
Cdd:cd17335 268 LGLLAYVVrWLLYSFLENPWLVLPIELLhgLTFALVWA-AAVSYASAAA-PPGLRATAQGLLQGLYFgLGGGLGSLIGGY 345
|
410 420
....*....|....*....|....*..
gi 217416366 433 A-QEVSPCGPPSLGAVLALVAIFIMSL 458
Cdd:cd17335 346 LyEAFGARTTFRFFAIAALAGLLAFFL 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-458 |
4.73e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.85 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRR------SSLLACILLS 119
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilaDLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 120 ALGYLLLGAATNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELeDGFYL 199
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL-LGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 200 TAFICFLVFILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLLgrshdtvqeaatsRRARASKktaqpwvevvlalrnmkn 279
Cdd:cd06173 160 AFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGL-------------RYLRRSP------------------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 280 llfsEMWDIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYKHNSqaLLLHSSI 359
Cdd:cd06173 209 ----LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR--LLLIGAL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 360 LTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPC 439
Cdd:cd06173 283 LLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
410 420
....*....|....*....|.
gi 217416366 440 GPP--SLGAVLALVAIFIMSL 458
Cdd:cd06173 363 SAVflLAGALLLLAALLLLLL 383
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
45-239 |
6.26e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 45 FLLCLYLVGFldlfGVSMVVPLLSLH-VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDV-VGRRSSLLACILLSALG 122
Cdd:cd17471 1 LLLATLLTGL----AGAFVLPYLSLFlTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 123 YLLLGAATNVFLFVLARVP-----AGIFKHTLSISRALLsDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELED-- 195
Cdd:cd17471 77 YLLFAFLRNYWVLLLVGVVllslgAAAFPQLFALAREYA-DRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGft 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 217416366 196 GFYLTAFICFLVFILnagLVWFF-PWREAKPGSTEKGLPLRKTHV 239
Cdd:cd17471 156 GLFLLAALLYLVVAL---LVLFLlPSVKPPAQKATPASSLVKAPV 197
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
71-224 |
7.95e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 71 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSS--LLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHT 148
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 217416366 149 LSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLTAFICFLVFILNAGLVWFFPWREAK 224
Cdd:COG2271 288 AFGLLwALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA--TGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
49-218 |
1.27e-06 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 50.29 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLDLFGVSMVVPLLSLHVKSL--GASPTVAGIVGSSYGILQLFSSTLVGCWSD---------VVGRRSSLLACIL 117
Cdd:cd17326 4 MYLTMFLSSLQFSIVLTSIWPYLQKIdpTATASFFGWVVAAYSLGQLVFSPVFGYWSNktssvkeplIVSILIAIVGNIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 118 LSALGYLLLGaatNVFLFVLARVPAGIFKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL-EDG 196
Cdd:cd17326 84 YALAEYFPSN---RKYVMLVARFLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIgYPG 160
|
170 180 190
....*....|....*....|....*....|...
gi 217416366 197 FYLT-----------AFICFLVFILNAGLVWFF 218
Cdd:cd17326 161 YVIGiklrfnmytapAWLMAILGIINIILILFF 193
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
39-228 |
2.73e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.49 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 39 AVGARRFLLC--LYLVGFLDLFGVSMVVPLLSlhVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLAC- 115
Cdd:COG2223 201 ALRDPRFWLLslLYFGTFGSFIGFSSWLPPYL--VDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVf 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 116 ILLSALGYLLLGAATNVFLFVLARVPAGIFKHTLSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELe 194
Cdd:COG2223 279 ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA- 357
|
170 180 190
....*....|....*....|....*....|....*
gi 217416366 195 DGFYLTAFICFLVF-ILNAGLVWFFPWREAKPGST 228
Cdd:COG2223 358 TGSYTAAFLVFAVLaLVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
49-456 |
4.29e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.78 E-value: 4.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 49 LYLVGFLdLFGVSMVVPL----LSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVV----GRR------SSLLA 114
Cdd:cd17313 1 LFLLGFG-FFGIEFGWALensyVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCnsriGRRrpfilvGAPLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 115 CI------------LLSALGYLLLGAATNVFLFVLARVPAGIFkhtLSISRALLSDVVPEKERPLVIGHFNTASGVGFIL 182
Cdd:cd17313 80 ALglilipnaadigLALGDGPRTWALVLFVLGIVLLDFAMNVC---QGPVRALLPDLVPPEQRSKANGIINFMGGLGGVL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 183 GPVVGGYL-----------TELEDGFYLTAFIcFLVFILnaGLVWFFPWREAKPGSTEKGLPlrkthvllgrshdtvqea 251
Cdd:cd17313 157 GYLLGAILwdhnwfgfalgGNLKVPFYIGAII-LLVCVL--VTLFFVKEPPLSPEAGEHSEN------------------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 252 atsrraraskktaQPWVEVVLALRNMKNLLFSEMWDIFLVRLL--MA-MAVMLYYSNFVlALEERFGVRPKVTGYLISYS 328
Cdd:cd17313 216 -------------PSLGEVLKSLLKLLKIMPRSLLRLLLVIFFwwIAfFPFELFFTDYM-GEEVYHGTSAASSHYGAGVR 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 329 ---------SMLGAVAGLALGPILRLYKHnsQALLLHSSILTCTLLLLYSLAPTMGAVVLSSTLLSFSTAIgrTCITDLQ 399
Cdd:cd17313 282 mgawgllifSLAFLIFSLPIGKLGKKIGR--KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWAT--ININPYP 357
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217416366 400 LTV----GGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVSPCGPP-SLGAVLALVAIFIM 456
Cdd:cd17313 358 LVSdyhsESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVfPVAAVASFLSLVGA 419
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
50-218 |
5.00e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.36 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 50 YLVGFLDLFGVSMVVPLLSLHVKSLGASptVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAA 129
Cdd:cd17489 200 ALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 130 TNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedGFYLTAFICFLVF 208
Cdd:cd17489 278 GSPWMLLLAAVLYGLgFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL--FGYRAMFLLAAVV 355
|
170
....*....|
gi 217416366 209 ILNAGLVWFF 218
Cdd:cd17489 356 VLLALVLYIF 365
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
46-218 |
5.24e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.41 E-value: 5.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSLHVKSLGAS----PTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSAL 121
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGDasnlAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 122 GYLLLGAATNVFLFVLARVPAGIFKHTLSIS-RALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE---LEDGF 197
Cdd:cd17391 283 LYIPQAFVQTPWQLGILRFLLGLATGGLLPAiNSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAhfgYRAVF 362
|
170 180
....*....|....*....|.
gi 217416366 198 YLTAficfLVFILNAGLVWFF 218
Cdd:cd17391 363 VVTA----LLVLLNAIWSFIF 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-179 |
5.47e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 5.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 14 RLVSETAERKQEQKTGTEAEAAdsgavgARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKS-LGASPTVAGIVGSSYGILQ 92
Cdd:COG2814 183 RLLPESRPAARARLRGSLRELL------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGG 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 93 LFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERPLVIGH 171
Cdd:COG2814 257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGL 336
|
....*...
gi 217416366 172 FNTASGVG 179
Cdd:COG2814 337 YNSAFFLG 344
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
72-192 |
5.76e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.34 E-value: 5.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 72 KSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHTL-S 150
Cdd:cd17503 24 GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLiP 103
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 217416366 151 ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE 192
Cdd:cd17503 104 LAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTD 145
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
54-217 |
1.03e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 47.64 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 54 FLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVF 133
Cdd:cd17476 8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 134 LFVLARVPAGI-FKHTLSISRALLSDVVPE-KERPLVIGHFNTASGVGFILGPVVGGYLTELED---GFYLTAFICFLVF 208
Cdd:cd17476 88 FFIICRALQGLgPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWwpwIFWFLAILAAIVA 167
|
....*....
gi 217416366 209 IlnAGLVWF 217
Cdd:cd17476 168 V--AAIFWT 174
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
74-455 |
1.13e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 74 LGASPTVAGIVGSSYGILQLFSSTLVGCWSDVV----GRR-------SSLLACILLSALGYLLLGAATNVFLFVLARVPA 142
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRrpwiligAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 143 GIFKHTLSIS-RALLSDVVPE-KERPLVIGHFNTASGVGFILGPVVGGYLTEL-----EDGFYLTAFICFLVFILnAGLV 215
Cdd:COG2211 121 GLAYTLVNIPySALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaALGYRLTALIFAVLGLL-AFLL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 216 WFFPWREAKPGSTEKglplrkthvllgrshdtvqeaatsrraraskktaQPWVEVVLALRNMKNLLFsemwdIFLVRLLM 295
Cdd:COG2211 200 TFFGTKERPVPEEEK----------------------------------VSLKESLKALLKNRPFLL-----LLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 296 AMAVMLYYSNFVLALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLY-KHNsqALLLHSSILTCTLLLLYSLAPT- 373
Cdd:COG2211 241 FLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgKKK--AFIIGLLLAALGLLLLFFLGPGn 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 374 ----MGAVVLSSTLLSFSTAIGRTCITDL---QLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGVAQEVS---PCGPPS 443
Cdd:COG2211 319 lwllLVLAALAGIGLGAILVLPWAMLADVvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFgyvAGAAQS 398
|
410
....*....|..
gi 217416366 444 LGAVLALVAIFI 455
Cdd:COG2211 399 PSALTGIRLLFF 410
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
54-218 |
1.92e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 54 FLDLFGVSMVVPLLSlHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVF 133
Cdd:cd17316 12 AYDFFLIGFVAPVLA-AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 134 LFVLARVPAGIF-KHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG-------FYLTAFICF 205
Cdd:cd17316 91 LLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrilFLIGALPAL 170
|
170
....*....|....*...
gi 217416366 206 LVFILN-----AGLVWFF 218
Cdd:cd17316 171 LALLLRrrtllLILLWFF 188
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
42-225 |
5.67e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.45 E-value: 5.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 42 ARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSAL 121
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 122 GYLLLGAATNVFLFVLARVPAGIFKHT-LSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLT 200
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAgSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162
|
170 180
....*....|....*....|....*
gi 217416366 201 AFIcFLVFILNAGLVWFFpWREAKP 225
Cdd:TIGR00710 163 AFL-SLAGILLSALIFFI-LPETLP 185
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
39-210 |
5.85e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 5.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 39 AVGARRFLLCLYLVGFLDLF-GVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGC-WSDVVGRRSSLLACI 116
Cdd:cd17490 189 SVLKDKKLLFFSLLAILQQMiTFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTlFYKKLGERNTIIIGF 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 117 LLSALGYLLLGAATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTE--- 192
Cdd:cd17490 269 LLLGAYCFLIPFAPNLTLLYLLQALNGFgTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEafg 348
|
170
....*....|....*...
gi 217416366 193 LEDGFYLTAFICFLVFIL 210
Cdd:cd17490 349 LQTGFFVIGVIALLAAIL 366
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-210 |
6.20e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 21 ERKQEQKTGTEAEAADSGAVGARRFLLCLYLVGFLDLFGVSMVVPLLSLHVK-SLGASPTVAGIVGSSYGILQLFSSTLV 99
Cdd:cd17474 175 EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFV 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 100 GCWSDV-VGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFkHTLSIS--RALLSDVVPEKERPLVIGHFNTAS 176
Cdd:cd17474 255 GRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG-LGLNLPllTTLVTELAPEEERGTASSLYNFVR 333
|
170 180 190
....*....|....*....|....*....|....*.
gi 217416366 177 GVGFILGPVVGGYLTEL--EDGFYLTAFICFLVFIL 210
Cdd:cd17474 334 FLGQAVGPLLFGLLLEIfgLSAPFLVGAAIALAAAV 369
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
43-191 |
7.18e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.04 E-value: 7.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 43 RRFLLCLYLVGF--LDLFGVSMVVPLLSlhvKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSA 120
Cdd:TIGR00895 17 RAIILSFLIMLMdgYDLAAMGFAAPAIS---AEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217416366 121 LGYLLLGAATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERPLVIGHFntasGVGFILGPVVGGYLT 191
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLM----FCGYPIGAAVGGFLA 161
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
58-210 |
9.92e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 9.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 58 FGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLAC--ILLSALGYLLLGAATNVFLF 135
Cdd:cd17477 202 FLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCalLGALAALLLPLVPGLPLALL 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 217416366 136 VLARVpAGIFKHTL-SISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL--EDGFYLTAFICFLVFIL 210
Cdd:cd17477 282 VLLFL-WGGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAfgPHGLFLFLAAVALLFLL 358
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
32-216 |
1.14e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 44.22 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 32 AEAADSGAVGARRFLLCLYLVGFLdLFGVSMVVP--LLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRR 109
Cdd:cd06180 183 TEASAAESAPGLNRPLWRLALAYG-LFGFGYIITatFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTR 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 110 SSLLACILLSALGYLLLGAATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKeRPLVIGHFNTASGVGFILGPVVGG 188
Cdd:cd06180 262 RALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGtFMAITALVMALARELAPPA-APRALALMTASFGVGQILGPLLAG 340
|
170 180
....*....|....*....|....*...
gi 217416366 189 YLTELEDGFYLTAFICFLVFILNAGLVW 216
Cdd:cd06180 341 WLADATGGFAPALILAAAALVVAALLAL 368
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-210 |
1.18e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 42 ARRFLLCLYLVGFLDLFGVSMVVPLLSLHVksLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSAL 121
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEV--LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 122 GYLLLGAATNVFLFVLARVPAGIFKHTLSISR-ALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDG---F 197
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLsavF 366
|
170
....*....|...
gi 217416366 198 YLTAFICFLVFIL 210
Cdd:cd06173 367 LLAGALLLLAALL 379
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
67-219 |
1.40e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.19 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 67 LSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAAT---NVFLFVLARVPAG 143
Cdd:pfam00083 34 LSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 144 IFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVgGYLTEL---EDGFYLTAFICFLVFILNAGLVWFFP 219
Cdd:pfam00083 114 IGVGGASvLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF-GLGLNKtsnSDGWRIPLGLQLVPALLLIIGLLFLP 192
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
54-230 |
1.42e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.08 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 54 FLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVF 133
Cdd:cd17478 6 FLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 134 LFVLARVPAGI---FKHTLSISRALLsdvVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELedgFYLTAFICFLVFIL 210
Cdd:cd17478 86 LLLLLVALAGIgsaAFHPEGARLASQ---AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAL---FGGLGLLILLIIPG 159
|
170 180
....*....|....*....|
gi 217416366 211 NAGLVWFFPWREAKPGSTEK 230
Cdd:cd17478 160 LAVALLLLRLRPLKKPEAKK 179
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
71-217 |
2.42e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 71 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKHT-L 149
Cdd:TIGR00881 22 VEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMgW 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217416366 150 SISRALLSDVVPEKERPLVIGHFNTASGVGFILGP-VVGGYLTELEDG---FYLTAFICFLVfilnaGLVWF 217
Cdd:TIGR00881 102 PPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWhwvFIVPGIIAIIV-----SLICF 168
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
71-218 |
2.67e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 71 VKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSD---VVGRRSSLLACILLSALGYLLLGAATNVFLFVLARVPAGIFKH 147
Cdd:cd17319 207 KQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 217416366 148 TLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLtAFICFLVFILNAGLVWFF 218
Cdd:cd17319 287 AASpVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTA-AFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
43-184 |
4.12e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 43 RRFLLCLYLVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRR-------SSLLAC 115
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlllalLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 217416366 116 ILLSALGYLLLGAATNVFLFVLARVPAGIfkhTLSISRALLSDVVPEKERPLVIGHFNTASGVGFILGP 184
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGL---VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-237 |
5.30e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 19 TAERKQEQKTGTEAeAADSGAVGARRFLLCLYLVGFLDLFGVSMVVPLLSLHVKS-LGASPTVAGIVGSSYGILQLFSST 97
Cdd:COG2211 204 TKERPVPEEEKVSL-KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAP 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 98 LVGCWSDVVGRRSSLLACILLSALGYLLLGAA--TNVFLFVLARVPAGIFKH-TLSISRALLSDVVPEKERP-------L 167
Cdd:COG2211 283 LWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGaILVLPWAMLADVVDYDEWKtgrrregL 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 168 VIGHFNTASGVGFILGPVVGGYL--------------TELEDGFYLTAFICFLVFILNAGLVWFFPWREAKPGSTEKGLP 233
Cdd:COG2211 363 YFGIFTFAIKLGQALAGALAGLLlalfgyvagaaqspSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
|
....
gi 217416366 234 LRKT 237
Cdd:COG2211 443 ARRA 446
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
55-193 |
5.30e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 42.37 E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 55 LDLFGVSMVVPLLslhVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLGAATNVFL 134
Cdd:TIGR00711 16 LDSTIVNVAIPTI---AGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 135 FVLARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTEL 193
Cdd:TIGR00711 93 MIIFRVIQGFGGGPLIpLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIEN 152
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
46-216 |
6.17e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 6.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGFLDLFGVSMVVPLLSLHVKSLGA-SPTVAGIVGSSYGILQLFSSTLVGCWSD-VVGRRSSLLACILLSALGY 123
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 124 LLLGAATNVFLFVLARVPAGIFKHTLS-ISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAF 202
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLpLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364
|
170
....*....|....
gi 217416366 203 ICFLVFILNAGLVW 216
Cdd:cd06174 365 VLAVLLLLAAILLL 378
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
89-210 |
6.98e-04 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 41.88 E-value: 6.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 89 GILQLFSSTLVGCWSDVVGRRSSLLACI------LLSALGYLLLGAATNVFLFVLARVPAGIFKH---TLSISRALLSDV 159
Cdd:cd17386 40 SIPPLFSSLFLGSWSDRYGRKPPLLMSLvglllsSLILVLIVYFTTVPSVWWFYLSAIPLALFGGftaFLSASFAYISDI 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 217416366 160 VPEKERPLVIGHFNTASGVGFILGPVVGGYLTElEDGFYLTAFI--CFLVFIL 210
Cdd:cd17386 120 SSEKKRTYRMAILEVALGLGGFLGSLLSGHLFK-ALGYAWSFSIsaALLLIAL 171
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
51-456 |
1.47e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 51 LVGFLDLFGVSMVVPLLSLHVKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRR-------SSLLACILLSALGY 123
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkplvilgYGLSALAKPLLALA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 124 LLLGAAtnVFLFVLARVPAGIFKhtlSISRALLSDVVPEKERPLVIGHFNTASGVGFILGPVVGGYLTELEDGFYLTAFI 203
Cdd:cd17370 86 GSWQLV--LLLRILERLGKGIRT---PPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 204 CFLVFILNAGLVWFFPWREAKPGSTEKGLPLRKTHVLLGRShdtvqeaatsrraraskktaqpwvevvlalrnmknllfs 283
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKA--------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 284 eMWDIFLVRLLMAMAvmlYYSNFVLALE-ERFGVRPKVTGYLISYSSMLGAVAGLALGpilRLYKHNSQALLLHSSILTC 362
Cdd:cd17370 202 -FWLYLLAVALFALG---NFSFAFLILRaQELGLSAALIPLLYALFNLVYALAAYPAG---RLSDRIGRKKLLILGYLSL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 363 TL-LLLYSLAPTMGAVVLSSTL----LSFSTAIGRTCITDLqltvGGAQASGTLIGVGQSVTAVGRIIAPLLSGV-AQEV 436
Cdd:cd17370 275 ALaYLGFALGSSLWLLLLGFILwglyMGAQESIERAAVADL----VPAELRGTAYGLFNTVVGIGWLLASLIAGYlWDLI 350
|
410 420
....*....|....*....|
gi 217416366 437 SPCGPPSLGAVLALVAIFIM 456
Cdd:cd17370 351 SPSAAFLFSAVLALIALLLL 370
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
93-223 |
2.13e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 40.18 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 93 LFSSTLVGCWSDVVGRRSSL-LACI---LLSALGYLLLGAATNVFLFVLARVPAGI---FKHTLSISRALLSDVVPEKER 165
Cdd:cd17449 79 LFSVTLLGPWSDSVGRRPVLiLPSLglaLQAAVYLLVMYLQLHVAYFLIGRILSGLlgdFNGILAGCFAYVADVSDRRSR 158
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 217416366 166 PLVIGHFNTASGVGFILGPVVGGYLTELEDgfYLTAFICFLVFILNAGLVWFFPWREA 223
Cdd:cd17449 159 TFRVAVLEACLGLAGMLASIIGGQWRKAQG--YINPFWLVLALNLAAALYAAFCVGES 214
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
82-355 |
2.55e-03 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 40.10 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 82 GIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGYLLLgAATNVFLFVLARVpAGIFKHTLSISRALLSDVVP 161
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-RISPWWYFAMISV-SGIFSVTFSVIFAYVADITT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 162 EKERPLVIGHFNTASGVGFILGPVVGGYLTELEdGFYLTAFICFLVFILNAGLVWFfpwreAKPGStekgLPLRkthvll 241
Cdd:cd17387 117 EEERSTAYGLVSATFAASLVTSPALGAYLSESY-GDNLVVLVATIVALLDICFILL-----AVPES----LPEK------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 242 grshdtvqEAATSRRARASKKTAQPWvEVVLALRNMKNLLFsemwdIFLVRLLMAMAVMLYYSNFVLALEERFGVRPKVT 321
Cdd:cd17387 181 --------MRPASWGAPISWEQADPF-ASLRKVGKDKTVLL-----ICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEV 246
|
250 260 270
....*....|....*....|....*....|....
gi 217416366 322 GYLISYSSMLGAVAGLALGPILRLYKHNSQALLL 355
Cdd:cd17387 247 AAFIAVVGILSITAQTLLLSILMRSIGAKNTILL 280
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
289-474 |
4.99e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 4.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 289 FLVRLLMAMAVMLYYSNFVL-----ALEERFGVRPKVTGYLISYSSMLGAVAGLALGPILRLYkhNSQALLLHSSILTCT 363
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVlpalpLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF--GRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 364 LLLLYSLAPTMGAVVLSSTLLSFSTAIGRTCITDLQLTVGGAQASGTLIGVGQSVTAVGRIIAPLLSGV-AQEVSPCGPP 442
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLlADLFGWRWVF 167
|
170 180 190
....*....|....*....|....*....|..
gi 217416366 443 SLGAVLALVAIFIMSLNKRHSSGDGNSKLKSE 474
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-190 |
5.13e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.11 E-value: 5.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217416366 46 LLCLYLVGF--LDLFGVSMVVPLLSlhvKSLGASPTVAGIVGSSYGILQLFSSTLVGCWSDVVGRRSSLLACILLSALGY 123
Cdd:cd17365 2 ALCFLIIVLdgFDLAVMGFVAPALA---QDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 217416366 124 LLLGAATNVFLFVLARVPAGI-FKHTLSISRALLSDVVPEKERplviGHFNTASGVGFILGPVVGGYL 190
Cdd:cd17365 79 LLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRR----SLAVTLMFCGYPLGAALGGFL 142
|
|
| |
