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Conserved domains on  [gi|281306830|ref|NP_116269|]
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immunoglobulin superfamily member 21 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 372-432 1.78e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05731:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 83  Bit Score: 45.86  E-value: 1.78e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281306830 372 PEPMFTWTRVGSRLLDGSAEFD--GKELVLERVPAELNGSmYRCTAQNPLGSTdTHTRLIVFE 432
Cdd:cd05731   23 PTPDIRWIKLGGELPKGRTKFEnfNKTLKIENVSEADSGE-YQCTASNTMGSA-RHTISVTVE 83
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 30-130 2.89e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05713:

Pssm-ID: 472250  Cd Length: 114  Bit Score: 43.33  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  30 IEPLPPVVA--GDAVTLKCNF--KTDGRMREIVWYRvtdggtikqkiftfdAMFStNYSH------------MENYRKRE 93
Cdd:cd05713    4 IGPTEPILAlvGEDAELPCHLspKMSAEHMEVRWFR---------------SQFS-PVVHlyrdgqdqeeeqMPEYRGRT 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 281306830  94 DLVYQS------TVRLPEVRISDNGPYECHV---GIYDRATREKVV 130
Cdd:cd05713   68 ELLKDAiaegsvALRIHNVRPSDEGQYTCFFrsgSFYEEATLELKV 113
 
Name Accession Description Interval E-value
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 372-432 1.78e-06

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 45.86  E-value: 1.78e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281306830 372 PEPMFTWTRVGSRLLDGSAEFD--GKELVLERVPAELNGSmYRCTAQNPLGSTdTHTRLIVFE 432
Cdd:cd05731   23 PTPDIRWIKLGGELPKGRTKFEnfNKTLKIENVSEADSGE-YQCTASNTMGSA-RHTISVTVE 83
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 30-130 2.89e-05

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 43.33  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  30 IEPLPPVVA--GDAVTLKCNF--KTDGRMREIVWYRvtdggtikqkiftfdAMFStNYSH------------MENYRKRE 93
Cdd:cd05713    4 IGPTEPILAlvGEDAELPCHLspKMSAEHMEVRWFR---------------SQFS-PVVHlyrdgqdqeeeqMPEYRGRT 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 281306830  94 DLVYQS------TVRLPEVRISDNGPYECHV---GIYDRATREKVV 130
Cdd:cd05713   68 ELLKDAiaegsvALRIHNVRPSDEGQYTCFFrsgSFYEEATLELKV 113
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 344-417 4.61e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.78  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  344 PKIVMTPS--RARVGDTVRI--LVHGFqnevfPEPMFTWTRVGSRLLDGSA-----EFDGKELVLERVPAELNGsMYRCT 414
Cdd:pfam13927   2 PVITVSPSsvTVREGETVTLtcEATGS-----PPPTITWYKNGEPISSGSTrsrslSGSNSTLTISNVTRSDAG-TYTCV 75


                  ...
gi 281306830  415 AQN 417
Cdd:pfam13927  76 ASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 353-430 5.96e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 5.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830   353 ARVGDTVRILVHGFQNevfPEPMFTWTRVGSRLLDGSAEFDGKE------LVLERVPAELNGsMYRCTAQNPLGSTDTHT 426
Cdd:smart00410   6 VKEGESVTLSCEASGS---PPPEVTWYKQGGKLLAESGRFSVSRsgststLTISNVTPEDSG-TYTCAATNSSGSASSGT 81


                   ....
gi 281306830   427 RLIV 430
Cdd:smart00410  82 TLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-119 1.09e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 41.29  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830   30 IEPLPPVVA-GDAVTLKCNFKTDGRMR--EIVWYRVTDGGTIKQKIFTFDAMfSTNYSHMENYRKREDLVYQS-TVRLPE 105
Cdd:pfam07686   1 QTPREVTVAlGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNG-SEEGVKKGRFSGRGDPSNGDgSLTIQN 79

                          90
                  ....*....|....
gi 281306830  106 VRISDNGPYECHVG 119
Cdd:pfam07686  80 LTLSDSGTYTCAVI 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 36-140 3.40e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 3.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830    36 VVAGDAVTLKCNFKTDGRMrEIVWYRVtdggtiKQKIFTFDAMFSTNYSHmenyrkredlvYQSTVRLPEVRISDNGPYE 115
Cdd:smart00410   6 VKEGESVTLSCEASGSPPP-EVTWYKQ------GGKLLAESGRFSVSRSG-----------STSTLTISNVTPEDSGTYT 67

                           90       100
                   ....*....|....*....|....*
gi 281306830   116 CHVgiydratREKVVLASGNIFLNV 140
Cdd:smart00410  68 CAA-------TNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 372-432 1.78e-06

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 45.86  E-value: 1.78e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281306830 372 PEPMFTWTRVGSRLLDGSAEFD--GKELVLERVPAELNGSmYRCTAQNPLGSTdTHTRLIVFE 432
Cdd:cd05731   23 PTPDIRWIKLGGELPKGRTKFEnfNKTLKIENVSEADSGE-YQCTASNTMGSA-RHTISVTVE 83
IgI_3_NCAM-1 cd05730
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...
 371-431 1.44e-05

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.


Pssm-ID: 143207 [Multi-domain]  Cd Length: 95  Bit Score: 43.77  E-value: 1.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281306830 371 FPEPMFTWTRVGSRLLDG----SAEFDGKELVLERVPAELNGSmYRCTAQNPLGSTDTHTRLIVF 431
Cdd:cd05730   30 FPEPTMTWTKDGEPIESGeekySFNEDGSEMTILDVDKLDEAE-YTCIAENKAGEQEAEIHLKVF 93
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 30-130 2.89e-05

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 43.33  E-value: 2.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  30 IEPLPPVVA--GDAVTLKCNF--KTDGRMREIVWYRvtdggtikqkiftfdAMFStNYSH------------MENYRKRE 93
Cdd:cd05713    4 IGPTEPILAlvGEDAELPCHLspKMSAEHMEVRWFR---------------SQFS-PVVHlyrdgqdqeeeqMPEYRGRT 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 281306830  94 DLVYQS------TVRLPEVRISDNGPYECHV---GIYDRATREKVV 130
Cdd:cd05713   68 ELLKDAiaegsvALRIHNVRPSDEGQYTCFFrsgSFYEEATLELKV 113
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 344-417 4.61e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.78  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  344 PKIVMTPS--RARVGDTVRI--LVHGFqnevfPEPMFTWTRVGSRLLDGSA-----EFDGKELVLERVPAELNGsMYRCT 414
Cdd:pfam13927   2 PVITVSPSsvTVREGETVTLtcEATGS-----PPPTITWYKNGEPISSGSTrsrslSGSNSTLTISNVTRSDAG-TYTCV 75


                  ...
gi 281306830  415 AQN 417
Cdd:pfam13927  76 ASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 353-430 5.96e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 5.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830   353 ARVGDTVRILVHGFQNevfPEPMFTWTRVGSRLLDGSAEFDGKE------LVLERVPAELNGsMYRCTAQNPLGSTDTHT 426
Cdd:smart00410   6 VKEGESVTLSCEASGS---PPPEVTWYKQGGKLLAESGRFSVSRsgststLTISNVTPEDSG-TYTCAATNSSGSASSGT 81


                   ....
gi 281306830   427 RLIV 430
Cdd:smart00410  82 TLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 30-119 1.09e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 41.29  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830   30 IEPLPPVVA-GDAVTLKCNFKTDGRMR--EIVWYRVTDGGTIKQKIFTFDAMfSTNYSHMENYRKREDLVYQS-TVRLPE 105
Cdd:pfam07686   1 QTPREVTVAlGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNG-SEEGVKKGRFSGRGDPSNGDgSLTIQN 79

                          90
                  ....*....|....
gi 281306830  106 VRISDNGPYECHVG 119
Cdd:pfam07686  80 LTLSDSGTYTCAVI 93
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 28-129 2.34e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 40.51  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  28 VNIEPLPPVVAGDAVTLKCNFKTDGRMR--EIVWYRvtDGGTIKQKIFTFDAMFSTNYShmENYRKREDLVYQS------ 99
Cdd:cd05718    3 VQVPTEVTGFLGGSVTLPCSLTSPGTTKitQVTWMK--IGAGSSQNVAVFHPQYGPSVP--NPYAERVEFLAARlglrna 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 281306830 100 TVRLPEVRISDNGPYECHVGIYDRATREKV 129
Cdd:cd05718   79 TLRIRNLRVEDEGNYICEFATFPQGNRQGT 108
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 371-426 3.57e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.85  E-value: 3.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281306830 371 FPEPMFTWTRVGSRLL-----DGSAEFDGKELVLERVPAELNGSmYRCTAQNPLGSTDTHT 426
Cdd:cd00096   10 NPPPTITWYKNGKPLPpssrdSRRSELGNGTLTISNVTLEDSGT-YTCVASNSAGGSASAS 69
I-set pfam07679
Immunoglobulin I-set domain;
344-430 7.61e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 7.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  344 PKIVMTPSR--ARVGDTVRilvhgFQNEV--FPEPMFTWTRVGSRLLDGSA---EFDGKE--LVLERVPAELNGSmYRCT 414
Cdd:pfam07679   1 PKFTQKPKDveVQEGESAR-----FTCTVtgTPDPEVSWFKDGQPLRSSDRfkvTYEGGTytLTISNVQPDDSGK-YTCV 74

                          90
                  ....*....|....*.
gi 281306830  415 AQNPLGSTDTHTRLIV 430
Cdd:pfam07679  75 ATNSAGEAEASAELTV 90
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 36-116 8.57e-04

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 38.86  E-value: 8.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830  36 VVAGDAVTLKCNFKTDGRMREIVWYRVTDGGtiKQKIFTFDAMFSTNYshMENYRKR----EDLVYQSTVRLPEVRISDN 111
Cdd:cd05846   10 AVLGGNATLSCNLTLPEEVLQVTWQKIKASS--PENIVTYSKKYGVKI--QPSYVRRisftSSGLNSTSITIWNVTLEDE 85


                 ....*
gi 281306830 112 GPYEC 116
Cdd:cd05846   86 GCYKC 90
IgI_3_Robo cd05725
Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 355-430 2.80e-03

Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409390 [Multi-domain]  Cd Length: 83  Bit Score: 36.60  E-value: 2.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281306830 355 VGDTVRilvhgFQNEVF--PEPMFTWTRVGSRLLDGSAE-FDGKELVLERVPAELNGSmYRCTAQNPLGSTDTHTRLIV 430
Cdd:cd05725   11 VDDSAE-----FQCEVGgdPVPTVRWRKEDGELPKGRYEiLDDHSLKIRKVTAGDMGS-YTCVAENMVGKIEASATLTV 83
Ig3_Peroxidasin cd05745
Third immunoglobulin (Ig)-like domain of peroxidasin; The members here are composed of the ...
 371-430 3.35e-03

Third immunoglobulin (Ig)-like domain of peroxidasin; The members here are composed of the third immunoglobulin (Ig)-like domain in peroxidasin. Peroxidasin has a peroxidase domain and interacting extracellular motifs containing four Ig-like domains. It has been suggested that peroxidasin is secreted and has functions related to the stabilization of the extracellular matrix. It may play a part in various other important processes such as removal and destruction of cells which have undergone programmed cell death and protection of the organism against non-self.


Pssm-ID: 143222 [Multi-domain]  Cd Length: 74  Bit Score: 36.45  E-value: 3.35e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281306830 371 FPEPMFTWTRVGSRLldgsaEFDGKELVLE-------RVPAELNGSmYRCTAQNPLGSTDTHTRLIV 430
Cdd:cd05745   14 YPQPVIAWTKGGSQL-----SVDRRHLVLSsgtlrisRVALHDQGQ-YECQAVNIVGSQRTVAQLTV 74
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 36-140 3.40e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 3.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830    36 VVAGDAVTLKCNFKTDGRMrEIVWYRVtdggtiKQKIFTFDAMFSTNYSHmenyrkredlvYQSTVRLPEVRISDNGPYE 115
Cdd:smart00410   6 VKEGESVTLSCEASGSPPP-EVTWYKQ------GGKLLAESGRFSVSRSG-----------STSTLTISNVTPEDSGTYT 67

                           90       100
                   ....*....|....*....|....*
gi 281306830   116 CHVgiydratREKVVLASGNIFLNV 140
Cdd:smart00410  68 CAA-------TNSSGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 27-118 4.54e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281306830   27 TVNIEPLPPVVA-GDAVTLKCNFKTDGRMrEIVWYRvtDGGTIKQkiftfdamfstnyshmENYRKREDLVYQSTVRLPE 105
Cdd:pfam13927   3 VITVSPSSVTVReGETVTLTCEATGSPPP-TITWYK--NGEPISS----------------GSTRSRSLSGSNSTLTISN 63

                          90
                  ....*....|...
gi 281306830  106 VRISDNGPYECHV 118
Cdd:pfam13927  64 VTRSDAGTYTCVA 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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