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Conserved domains on  [gi|34878735|ref|NP_149438|]
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F-box only protein 44 isoform 1 [Homo sapiens]

Protein Classification

F-box protein( domain architecture ID 17779909)

F-box protein is the substrate-recognition component of an SCF (Skp1-cullin-F-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  11178263|31898225
SCOP:  4001927

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FBA pfam04300
F-box associated region; Members of this family are associated with F-box domains, hence the ...
72-250 3.92e-106

F-box associated region; Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Swiss:Q9UK22 is involved in binding to N-glycosylated proteins.


:

Pssm-ID: 461255  Cd Length: 175  Bit Score: 304.50  E-value: 3.92e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735    72 YFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLsrdqRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELM 151
Cdd:pfam04300   1 YFLRPLGRNLIKNPCGEEGLKHWEIVENGGDGWKVEEN----GEPLPDASVQKCFVTSYRWCLKSQLIDLKAEGLWPELL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735   152 DTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIWFQHGGVD 231
Cdd:pfam04300  77 DSFQPEIKVSDWYAARQDCGCIYELHVQLLDANKTVLAEFSPEPVPIPQWNDNQWFQVSHVFSNYGPGVRFIRFEHGGKD 156
                         170
                  ....*....|....*....
gi 34878735   232 THYWAGWYGPRVTNSSITI 250
Cdd:pfam04300 157 TQFWAGHYGIRVTNSSVIV 175
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
3-85 4.82e-45

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 145.89  E-value: 4.82e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735   3 VGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFLRsLHRNLL 82
Cdd:cd22168   1 MLTISDLPEDVLLEILSLVPARDLILSCRLVCSRWRDLVDLPTLWKRKCQREGFILKDWDGPPKDWKIFYFLR-LERNLL 79

                ...
gi 34878735  83 HNP 85
Cdd:cd22168  80 KNP 82
 
Name Accession Description Interval E-value
FBA pfam04300
F-box associated region; Members of this family are associated with F-box domains, hence the ...
72-250 3.92e-106

F-box associated region; Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Swiss:Q9UK22 is involved in binding to N-glycosylated proteins.


Pssm-ID: 461255  Cd Length: 175  Bit Score: 304.50  E-value: 3.92e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735    72 YFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLsrdqRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELM 151
Cdd:pfam04300   1 YFLRPLGRNLIKNPCGEEGLKHWEIVENGGDGWKVEEN----GEPLPDASVQKCFVTSYRWCLKSQLIDLKAEGLWPELL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735   152 DTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIWFQHGGVD 231
Cdd:pfam04300  77 DSFQPEIKVSDWYAARQDCGCIYELHVQLLDANKTVLAEFSPEPVPIPQWNDNQWFQVSHVFSNYGPGVRFIRFEHGGKD 156
                         170
                  ....*....|....*....
gi 34878735   232 THYWAGWYGPRVTNSSITI 250
Cdd:pfam04300 157 TQFWAGHYGIRVTNSSVIV 175
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
3-85 4.82e-45

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 145.89  E-value: 4.82e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735   3 VGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFLRsLHRNLL 82
Cdd:cd22168   1 MLTISDLPEDVLLEILSLVPARDLILSCRLVCSRWRDLVDLPTLWKRKCQREGFILKDWDGPPKDWKIFYFLR-LERNLL 79

                ...
gi 34878735  83 HNP 85
Cdd:cd22168  80 KNP 82
F-box-like pfam12937
F-box-like; This is an F-box-like family.
6-51 2.63e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 49.02  E-value: 2.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34878735     6 INELPENILLELFTHVPARQLLlNCRLVCSLWRDLIDLVTLWKRKC 51
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLL-RLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-50 3.37e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.51  E-value: 3.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 34878735      9 LPENILLELFTHVPARQLLlNCRLVCSLWRDLIDLVTLWKRK 50
Cdd:smart00256   1 LPDEILEEILSKLDPKDLL-RLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
FBA pfam04300
F-box associated region; Members of this family are associated with F-box domains, hence the ...
72-250 3.92e-106

F-box associated region; Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Swiss:Q9UK22 is involved in binding to N-glycosylated proteins.


Pssm-ID: 461255  Cd Length: 175  Bit Score: 304.50  E-value: 3.92e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735    72 YFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLsrdqRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELM 151
Cdd:pfam04300   1 YFLRPLGRNLIKNPCGEEGLKHWEIVENGGDGWKVEEN----GEPLPDASVQKCFVTSYRWCLKSQLIDLKAEGLWPELL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735   152 DTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIWFQHGGVD 231
Cdd:pfam04300  77 DSFQPEIKVSDWYAARQDCGCIYELHVQLLDANKTVLAEFSPEPVPIPQWNDNQWFQVSHVFSNYGPGVRFIRFEHGGKD 156
                         170
                  ....*....|....*....
gi 34878735   232 THYWAGWYGPRVTNSSITI 250
Cdd:pfam04300 157 TQFWAGHYGIRVTNSSVIV 175
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
3-85 4.82e-45

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 145.89  E-value: 4.82e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34878735   3 VGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFLRsLHRNLL 82
Cdd:cd22168   1 MLTISDLPEDVLLEILSLVPARDLILSCRLVCSRWRDLVDLPTLWKRKCQREGFILKDWDGPPKDWKIFYFLR-LERNLL 79

                ...
gi 34878735  83 HNP 85
Cdd:cd22168  80 KNP 82
F-box_FBXO2 cd22167
F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called ...
6-74 4.06e-19

F-box domain found in F-box only protein 2 (FBXO2) and similar proteins; FBXO2, also called FBX2, is a neuron-specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It binds specifically to proteins attached with N-linked high-mannose type oligosaccharides, and subsequently contributes to ubiquitination of glycoproteins. FBXO2 regulates amyloid precursor protein (APP) levels and processing in the brain, and may play a role in modulating Alzheimer disease (AD) pathogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438938 [Multi-domain]  Cd Length: 72  Bit Score: 78.63  E-value: 4.06e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34878735   6 INELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFL 74
Cdd:cd22167   1 MESLPEAVLVRILAYLPAEELVLVCRLVCSQWKELVDGAALWILKCQQEGFSPTELEEEPDNWQTFYFL 69
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
6-42 2.98e-15

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 67.41  E-value: 2.98e-15
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 34878735   6 INELPENILLELFTHVPARQLLLNCRLVCSLWRDLID 42
Cdd:cd22083   1 LNEIPEELLLEILTHVPATSLITNCRLVCTLWRDIID 37
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
6-53 1.56e-12

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 60.51  E-value: 1.56e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 34878735   6 INELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLR 53
Cdd:cd22169   1 LSLLPEELLLLVLSHVPARTLVTRCRLVCRDWRDLVDGPTLWKLKCER 48
F-box-like pfam12937
F-box-like; This is an F-box-like family.
6-51 2.63e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 49.02  E-value: 2.63e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 34878735     6 INELPENILLELFTHVPARQLLlNCRLVCSLWRDLIDLVTLWKRKC 51
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLL-RLALVCRRWRELASDDSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-50 3.37e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 45.51  E-value: 3.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 34878735      9 LPENILLELFTHVPARQLLlNCRLVCSLWRDLIDLVTLWKRK 50
Cdd:smart00256   1 LPDEILEEILSKLDPKDLL-RLRKVSRKWRSLIDSHDFWFKL 41
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
6-48 3.41e-07

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 45.80  E-value: 3.41e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 34878735   6 INELPENILLELFTHVPARQLLLNCRlVCSLWRDLIDLVTLWK 48
Cdd:cd22123   1 LDQLPENVLLEILSYLPVRDLLRISR-VCKRWRRLVYDKTLWR 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
6-49 5.32e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.22  E-value: 5.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 34878735     6 INELPENILLELFTHVPARQLLlNCRLVCSLWRDLIDLVTLWKR 49
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLL-RLSLVSKRWRSLVDSLKLWKK 43
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
6-50 6.99e-07

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 44.96  E-value: 6.99e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 34878735   6 INELPENILLELFTHVPARQLLLNCRLVCSLWRDLI--DLVTLWKRK 50
Cdd:cd22095   2 IQQLPEELLRNIFAFLPAEDLYQNISLVCRHWRDIVsdPLFIPWKKL 48
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
6-42 2.01e-05

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 40.78  E-value: 2.01e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 34878735   6 INELPENILLELFTHVPARQLLLNCRLVCSLWRDLID 42
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIK 37
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
5-49 2.02e-05

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 40.87  E-value: 2.02e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 34878735   5 NINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKR 49
Cdd:cd22092   1 NINQLPDSILLKIFSYLSLQERCLSASLVCKYWRDLCLDSQFWKQ 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
7-42 3.93e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 39.73  E-value: 3.93e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 34878735   7 NELPENILLELFTHVPARQLLlNCRLVCSLWRDLID 42
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLL-RLSLVCKRWRELAS 35
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
6-54 3.70e-04

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 37.41  E-value: 3.70e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 34878735   6 INELPENILLELFTHVPARQLLlNCRLVCSLWRDLIDLVTLWKRKCLRE 54
Cdd:cd22102   1 ILDLPPELLVEIFSSLPGTDLP-SLAQVCKKFREILNTDTIWQRRCKEE 48
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
5-42 6.75e-04

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 36.84  E-value: 6.75e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 34878735   5 NINELPENILLELFTHVPARQlLLNCRLVCSLWRDLID 42
Cdd:cd22082   1 TLWSLPEEVLLHILKGLPIKD-LLNMRAVHSRFKDLID 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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