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Conserved domains on  [gi|110556636|ref|NP_203754|]
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182 kDa tankyrase-1-binding protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tankyrase_bdg_C pfam15327
Tankyrase binding protein C terminal domain; This protein domain family is found at the ...
 1556-1721 2.67e-44

Tankyrase binding protein C terminal domain; This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyzes poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.


:

Pssm-ID: 464648  Cd Length: 169  Bit Score: 158.43  E-value: 2.67e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  1556 DFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRP-----GGTLGLSEAADSDAHLFQDSTEPRA-SRVPSSDEEVVEep 1629
Cdd:pfam15327    1 DFSFIEQTSVLDSSALKTRAQLGKKRRRRAPPSRSlrrseAENGGPLEEEDDSAWMFKDSTEEKSpSRQEDSDEEEPE-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  1630 QSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGElaeskssqKESAVQRSKSCKVPGL--GKPLTLPPKPEK 1707
Cdd:pfam15327   79 QSPRSERSPVTQPQRVPLFPGMDPSALKAQLRKRNESDSPGE--------GPSPSQLSKSPKSPFLpgKGPRVLPPSGEK 150

                          170
                   ....*....|....
gi 110556636  1708 SSGSEGSSPNWLQA 1721
Cdd:pfam15327  151 ESGSEESSPQWLKE 164
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 95-463 4.24e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.34  E-value: 4.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   95 RPLPFAPRPAV---EASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTvEEILAKMEQP 171
Cdd:PHA03247 2572 RPAPRPSEPAVtsrARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDP-HPPPTVPPPE 2650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  172 RKEVLASPDRLWGSRLTfnhdgssrygprtygtTTAPRDEDGSTLFRGWSQEG---PVKSPAECREEHS--KTPEERSLP 246
Cdd:PHA03247 2651 RPRDDPAPGRVSRPRRA----------------RRLGRAAQASSPPQRPRRRAarpTVGSLTSLADPPPppPTPEPAPHA 2714

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  247 SDLAFNGDLA-KAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEA 325
Cdd:PHA03247 2715 LVSATPLPPGpAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  326 SQASPC---PAVTPSAPSAALPDEGSRHTPSPGLPaegAPEAPRPSSPPPevlephsldqPPATSPRPLIEVGELL---D 399
Cdd:PHA03247 2795 RESLPSpwdPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPP----------PPGPPPPSLPLGGSVApggD 2861

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110556636  400 LTRTFPSgGEEEAKGDAHLRPTSlvqRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRP 463
Cdd:PHA03247 2862 VRRRPPS-RSPAAKPAAPARPPV---RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 273-691 7.60e-05

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 7.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  273 PSSPAPSSENGGPASPGLPAEASG----SGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGs 348
Cdd:PRK07764  405 APAAAPAPAAAAPAAAAAPAPAAApqpaPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPA- 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  349 rhtPSPGLPAEGAPEAPRPSSPPP----------------EVLEPHSLDQPPATSPRPLieVGELLD--LTRTFPSGGEE 410
Cdd:PRK07764  484 ---PPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilAAVPKRSRKTWAILLPEAT--VLGVRGdtLVLGFSTGGLA 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  411 EAKGDAHlRPTSLVQrrfsegVLqspsqdQEKLGGSLA--ALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGlg 488
Cdd:PRK07764  559 RRFASPG-NAEVLVT------AL------AEELGGDWQveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA-- 623

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  489 vwrldSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVP 568
Cdd:PRK07764  624 -----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  569 LEPLPTTEGTPglPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPcvlfADAPEPGQALPVEE 648
Cdd:PRK07764  699 AQPAPAPAATP--PAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP----PPPPAPAPAAAPAA 772

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 110556636  649 EavtlARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLAS 691
Cdd:PRK07764  773 A----PPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEE 811
 
Name Accession Description Interval E-value
Tankyrase_bdg_C pfam15327
Tankyrase binding protein C terminal domain; This protein domain family is found at the ...
 1556-1721 2.67e-44

Tankyrase binding protein C terminal domain; This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyzes poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.


Pssm-ID: 464648  Cd Length: 169  Bit Score: 158.43  E-value: 2.67e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  1556 DFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRP-----GGTLGLSEAADSDAHLFQDSTEPRA-SRVPSSDEEVVEep 1629
Cdd:pfam15327    1 DFSFIEQTSVLDSSALKTRAQLGKKRRRRAPPSRSlrrseAENGGPLEEEDDSAWMFKDSTEEKSpSRQEDSDEEEPE-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  1630 QSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGElaeskssqKESAVQRSKSCKVPGL--GKPLTLPPKPEK 1707
Cdd:pfam15327   79 QSPRSERSPVTQPQRVPLFPGMDPSALKAQLRKRNESDSPGE--------GPSPSQLSKSPKSPFLpgKGPRVLPPSGEK 150

                          170
                   ....*....|....
gi 110556636  1708 SSGSEGSSPNWLQA 1721
Cdd:pfam15327  151 ESGSEESSPQWLKE 164
PHA03247 PHA03247
large tegument protein UL36; Provisional
 95-463 4.24e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.34  E-value: 4.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   95 RPLPFAPRPAV---EASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTvEEILAKMEQP 171
Cdd:PHA03247 2572 RPAPRPSEPAVtsrARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDP-HPPPTVPPPE 2650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  172 RKEVLASPDRLWGSRLTfnhdgssrygprtygtTTAPRDEDGSTLFRGWSQEG---PVKSPAECREEHS--KTPEERSLP 246
Cdd:PHA03247 2651 RPRDDPAPGRVSRPRRA----------------RRLGRAAQASSPPQRPRRRAarpTVGSLTSLADPPPppPTPEPAPHA 2714

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  247 SDLAFNGDLA-KAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEA 325
Cdd:PHA03247 2715 LVSATPLPPGpAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  326 SQASPC---PAVTPSAPSAALPDEGSRHTPSPGLPaegAPEAPRPSSPPPevlephsldqPPATSPRPLIEVGELL---D 399
Cdd:PHA03247 2795 RESLPSpwdPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPP----------PPGPPPPSLPLGGSVApggD 2861

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110556636  400 LTRTFPSgGEEEAKGDAHLRPTSlvqRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRP 463
Cdd:PHA03247 2862 VRRRPPS-RSPAAKPAAPARPPV---RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 273-691 7.60e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 7.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  273 PSSPAPSSENGGPASPGLPAEASG----SGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGs 348
Cdd:PRK07764  405 APAAAPAPAAAAPAAAAAPAPAAApqpaPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPA- 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  349 rhtPSPGLPAEGAPEAPRPSSPPP----------------EVLEPHSLDQPPATSPRPLieVGELLD--LTRTFPSGGEE 410
Cdd:PRK07764  484 ---PPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilAAVPKRSRKTWAILLPEAT--VLGVRGdtLVLGFSTGGLA 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  411 EAKGDAHlRPTSLVQrrfsegVLqspsqdQEKLGGSLA--ALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGlg 488
Cdd:PRK07764  559 RRFASPG-NAEVLVT------AL------AEELGGDWQveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA-- 623

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  489 vwrldSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVP 568
Cdd:PRK07764  624 -----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  569 LEPLPTTEGTPglPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPcvlfADAPEPGQALPVEE 648
Cdd:PRK07764  699 AQPAPAPAATP--PAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP----PPPPAPAPAAAPAA 772

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 110556636  649 EavtlARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLAS 691
Cdd:PRK07764  773 A----PPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEE 811
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 237-388 3.20e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   237 SKTPEERSLPSDLAFNGDLAKAASSELPADISKPW---IPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHP------- 306
Cdd:pfam05109  422 SKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTnltAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngtes 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   307 --PDKSSPCHSQLL-----------------EAQTPEASQASPCPAVTPSAPSAALPDEG-SRHTPSPGLPAEGApeapr 366
Cdd:pfam05109  502 kaPDMTSPTSAVTTptpnatsptpavttptpNATSPTLGKTSPTSAVTTPTPNATSPTPAvTTPTPNATIPTLGK----- 576

                          170       180
                   ....*....|....*....|..
gi 110556636   367 pSSPPPEVLEPhsldQPPATSP 388
Cdd:pfam05109  577 -TSPTSAVTTP----TPNATSP 593
 
Name Accession Description Interval E-value
Tankyrase_bdg_C pfam15327
Tankyrase binding protein C terminal domain; This protein domain family is found at the ...
 1556-1721 2.67e-44

Tankyrase binding protein C terminal domain; This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyzes poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.


Pssm-ID: 464648  Cd Length: 169  Bit Score: 158.43  E-value: 2.67e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  1556 DFSFIEDTEILDSAMYRSRANLGRKRGHRAPVIRP-----GGTLGLSEAADSDAHLFQDSTEPRA-SRVPSSDEEVVEep 1629
Cdd:pfam15327    1 DFSFIEQTSVLDSSALKTRAQLGKKRRRRAPPSRSlrrseAENGGPLEEEDDSAWMFKDSTEEKSpSRQEDSDEEEPE-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  1630 QSRRTRMSLGTKGLKVNLFPGLSPSALKAKLRPRNRSAEEGElaeskssqKESAVQRSKSCKVPGL--GKPLTLPPKPEK 1707
Cdd:pfam15327   79 QSPRSERSPVTQPQRVPLFPGMDPSALKAQLRKRNESDSPGE--------GPSPSQLSKSPKSPFLpgKGPRVLPPSGEK 150

                          170
                   ....*....|....
gi 110556636  1708 SSGSEGSSPNWLQA 1721
Cdd:pfam15327  151 ESGSEESSPQWLKE 164
PHA03247 PHA03247
large tegument protein UL36; Provisional
 95-463 4.24e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.34  E-value: 4.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   95 RPLPFAPRPAV---EASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTvEEILAKMEQP 171
Cdd:PHA03247 2572 RPAPRPSEPAVtsrARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDP-HPPPTVPPPE 2650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  172 RKEVLASPDRLWGSRLTfnhdgssrygprtygtTTAPRDEDGSTLFRGWSQEG---PVKSPAECREEHS--KTPEERSLP 246
Cdd:PHA03247 2651 RPRDDPAPGRVSRPRRA----------------RRLGRAAQASSPPQRPRRRAarpTVGSLTSLADPPPppPTPEPAPHA 2714

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  247 SDLAFNGDLA-KAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEA 325
Cdd:PHA03247 2715 LVSATPLPPGpAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  326 SQASPC---PAVTPSAPSAALPDEGSRHTPSPGLPaegAPEAPRPSSPPPevlephsldqPPATSPRPLIEVGELL---D 399
Cdd:PHA03247 2795 RESLPSpwdPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPP----------PPGPPPPSLPLGGSVApggD 2861

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110556636  400 LTRTFPSgGEEEAKGDAHLRPTSlvqRRFSEGVLQSPSQDQEKLGGSLAALPQGQGSQLALDRP 463
Cdd:PHA03247 2862 VRRRPPS-RSPAAKPAAPARPPV---RRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921
PHA03247 PHA03247
large tegument protein UL36; Provisional
 26-390 5.55e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 5.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   26 PTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSARKMNMLAGPQPYGGSKRPLPFAPRPAV 105
Cdd:PHA03247 2613 PPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  106 EASTGgeatqetgkeeagKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKMEQPRKEVLASPDRLWGS 185
Cdd:PHA03247 2693 GSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  186 RLTfnhdgssrygPRTYGTTTAPRDEDGSTLFRgwSQEGPVKSPAECREEHSKTPEERSLPSdlAFNGDLAKAASSELPA 265
Cdd:PHA03247 2760 PPT----------TAGPPAPAPPAAPAAGPPRR--LTRPAVASLSESRESLPSPWDPADPPA--AVLAPAAALPPAASPA 2825

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  266 DISKPWIPSSPAPSSENGGPASPGLPAEASgSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPcpAVTPSAPSAALPD 345
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGS-VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP--AVSRSTESFALPP 2902

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  346 EGSRHTPSPGLPAEGAPEA---------------PRPSSPPPEVLEPHSLDQPPATSPRP 390
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPqpppppqpqppppppPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-391 2.13e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.03  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636    5 TLRESSAMASPLPREMEEELVPTGSEPGD---------TRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAEL 75
Cdd:PHA03247 2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPappsplppdTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   76 PSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTggeatqetgkeeaGKEEPPPLTPPARCAAPGGVRKAPAPFRPASER 155
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-------------SLADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  156 FAATTVEEILAKMEQPRKEVLASPDRLWGSRLTfnhdgssrygPRTYGTTTAPRDEDGSTLFRgwSQEGPVKSPAECREE 235
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPATPGGPARPARPPT----------TAGPPAPAPPAAPAAGPPRR--LTRPAVASLSESRES 2797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  236 HSKTPEERSLPSdlAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASgSGPGSPHLHPPDKSSPCHS 315
Cdd:PHA03247 2798 LPSPWDPADPPA--AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS-VAPGGDVRRRPPSRSPAAK 2874

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110556636  316 QLLEAQTPEASQASpcPAVTPSAPSAALPDEGSRHTPSPGLPAEgapeaPRPSSPPPEVLEPHSLDQPPATSPRPL 391
Cdd:PHA03247 2875 PAAPARPPVRRLAR--PAVSRSTESFALPPDQPERPPQPQAPPP-----PQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
PHA03247 PHA03247
large tegument protein UL36; Provisional
 30-391 9.66e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.72  E-value: 9.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   30 EPGDTRAKPPVKPKPRALPAKPALPAKPSLLVPVGPRPPRGPLAELPSAR----KMNMLAGPQPYGGSKRPLPFAPRPAV 105
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARptvgSLTSLADPPPPPPTPEPAPHALVSAT 2719

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  106 EASTGGEATQETGKEEAGKEEPPPltPPARCAAPGGVRKAPAPFRPASERFAATtveeilakmeqPRKEVLASPDRLW-G 184
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPA--VPAGPATPGGPARPARPPTTAGPPAPAP-----------PAAPAAGPPRRLTrP 2786

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  185 SRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSD-----LAFNGDLAKAA 259
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggsVAPGGDVRRRP 2866

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  260 SSELPAdiSKPWIPSSPaPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLlEAQTPEASQASPCPAVTPSAP 339
Cdd:PHA03247 2867 PSRSPA--AKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP-QPPPPPQPQPPPPPPPRPQPP 2942

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 110556636  340 SAALPDEGSRHTPSPGLPAE-------GAPEAPRPSSPPPEVLEPhsldqPPATSPRPL 391
Cdd:PHA03247 2943 LAPTTDPAGAGEPSGAVPQPwlgalvpGRVAVPRFRVPQPAPSRE-----APASSTPPL 2996
PHA03247 PHA03247
large tegument protein UL36; Provisional
 269-678 4.35e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 4.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  269 KPWIPSSPA-PSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEG 347
Cdd:PHA03247 2588 RPDAPPQSArPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA 2667

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  348 SRHTPSPGlpAEGAPEAPRPSSPPPEV------LEPHSLDQPPATSPRPLIEVgelLDLTRTFPSGGEEEAKGDAHLRPT 421
Cdd:PHA03247 2668 RRLGRAAQ--ASSPPQRPRRRAARPTVgsltslADPPPPPPTPEPAPHALVSA---TPLPPGPAAARQASPALPAAPAPP 2742

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  422 SLVQRRFSEGVLQSPSQDQEKLGGSLAALPQGQ--GSQLALDRPFGAESNWSLSQSfewTFPTRPSglgvwrlDSPPPSP 499
Cdd:PHA03247 2743 AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaaGPPRRLTRPAVASLSESRESL---PSPWDPA-------DPPAAVL 2812

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  500 ITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQgddPSMSLTQKGDGESQPQFPAVPLEPLPTTEGTP 579
Cdd:PHA03247 2813 APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA---PGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  580 GL-----PLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPCVLFADAPEPGQALPVEEE-AVTL 653
Cdd:PHA03247 2890 AVsrsteSFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVP 2969

                         410       420
                  ....*....|....*....|....*
gi 110556636  654 ARAETTQARTEAQDLCRASPEPPGP 678
Cdd:PHA03247 2970 GRVAVPRFRVPQPAPSREAPASSTP 2994
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-372 3.93e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636    1 MKVSTLRESSAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPRALPA-KPALPAKPSLLVPVGPRPPRGPLAELPSAr 79
Cdd:PHA03307   85 RSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDlSEMLRPVGSPGPPPAASPPAAGASPAAVA- 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   80 kmnmlAGPQPYGGSKRPLPFAPRPAVEASTGGEA----TQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASER 155
Cdd:PHA03307  164 -----SDAASSRQAALPLSSPEETARAPSSPPAEpppsTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  156 FAATTVEEILAKMEQPRKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGStlfrgWSQEGPVKSPAECREE 235
Cdd:PHA03307  239 SSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPS-----PSPSSPGSGPAPSSPR 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  236 HSKTpEERSLPSDLAfngdlAKAASSELPAD-ISKPWIPSSPAPSSENGGPASPGLP---AEASGSGPGSPHLHPPDKSS 311
Cdd:PHA03307  314 ASSS-SSSSRESSSS-----STSSSSESSRGaAVSPGPSPSRSPSPSRPPPPADPSSprkRPRPSRAPSSPAASAGRPTR 387

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110556636  312 P-CHSQLLEAQTP-EASQASPCpAVTPSAPSAALPDEGSRHTPSPGLPAEGapeAPRPSSPPP 372
Cdd:PHA03307  388 RrARAAVAGRARRrDATGRFPA-GRPRPSPLDAGAASGAFYARYPLLTPSG---EPWPGSPPP 446
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 16-388 2.91e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.92  E-value: 2.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   16 LPREMEEELVPTGSEPGDTRAKPPVKPKPRALPakPALPAKPSllvpvgprpprgplaelpsarkmnmlagpqPYGGSKR 95
Cdd:PTZ00449  488 LIKKSKKKLAPIEEEDSDKHDEPPEGPEASGLP--PKAPGDKE------------------------------GEEGEHE 535

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   96 PLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAATTVEeilAKMEQPRKev 175
Cdd:PTZ00449  536 DSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRS---AQRPTRPK-- 610

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  176 laSPDRLWGSRLTfnhdgssrYGPRTYGTTTAPRDEDGSTlfRGWSQEGP--VKSPaecreEHSKTPEERSLPSDLAFN- 252
Cdd:PTZ00449  611 --SPKLPELLDIP--------KSPKRPESPKSPKRPPPPQ--RPSSPERPegPKII-----KSPKPPKSPKPPFDPKFKe 673

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  253 ---GDLAKAAS-----------SELPADISKPWIPSSPAPSSENGGPASPGLPAEasgsgPGSPHLHPPDksspchsqll 318
Cdd:PTZ00449  674 kfyDDYLDAAAksketkttvvlDESFESILKETLPETPGTPFTTPRPLPPKLPRD-----EEFPFEPIGD---------- 738

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  319 eaqtPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAE-----------GAPEAP--RPSSPppevlEPHSlDQPPA 385
Cdd:PTZ00449  739 ----PDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEefkeedihaetGEPDEAmkRPDSP-----SEHE-DKPPG 808


                  ...
gi 110556636  386 TSP 388
Cdd:PTZ00449  809 DHP 811
PHA03247 PHA03247
large tegument protein UL36; Provisional
 10-390 4.46e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 4.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   10 SAMASPLPREMEEELVPTGSEPGDTRAK--------PPVKPKPRALPAKPALPAKpslLVPVGPRPPRGPLAELPSARKM 81
Cdd:PHA03247 2643 PPTVPPPERPRDDPAPGRVSRPRRARRLgraaqassPPQRPRRRAARPTVGSLTS---LADPPPPPPTPEPAPHALVSAT 2719

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   82 NMLAGPQPYGGSKRPLPFAP----RPAVEASTGGEATQETGKEEAGKEEP-----PPLTPPARCAAPGGVRKAPA-PFRP 151
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPappaVPAGPATPGGPARPARPPTTAGPPAPappaaPAAGPPRRLTRPAVASLSESrESLP 2799

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  152 ASERFAATTVEEILAKMEQPRKEVLASPDrlwgsrltfnhdgssryGPRTYGTTTAPrdedgstlfrgwsqeGPVKSPae 231
Cdd:PHA03247 2800 SPWDPADPPAAVLAPAAALPPAASPAGPL-----------------PPPTSAQPTAP---------------PPPPGP-- 2845

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  232 creehskTPEERSLPSDLAFNGDLAKAASSELPAdiSKPWIPSSPaPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSS 311
Cdd:PHA03247 2846 -------PPPSLPLGGSVAPGGDVRRRPPSRSPA--AKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  312 PCHSQlLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAE-------GAPEAPRP--SSPPPEVLEPHSLDQ 382
Cdd:PHA03247 2916 PPQPQ-PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPwlgalvpGRVAVPRFrvPQPAPSREAPASSTP 2994


                  ....*...
gi 110556636  383 PPATSPRP 390
Cdd:PHA03247 2995 PLTGHSLS 3002
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 10-395 4.89e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 4.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   10 SAMASPLPReMEEELVPTGSEPGDTRAKPPVKPKPRALPAKPALPAKPSllVPVGPRPPRGPLAELPSARKmnmlAGPQP 89
Cdd:PRK07764  372 RGLLARLER-LERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAA--AAAPAPAAAPQPAPAPAPAP----APPSP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   90 YGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPfrpASERFAATTVE---EILA 166
Cdd:PRK07764  445 AGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP---AGADDAATLRErwpEILA 521

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  167 KMEQPRKEVL------ASPDRLWGSRLTFNHD-GSSRYGPRTYGTT----TAPRDEDGSTLfrgwsqegpvksPAECRee 235
Cdd:PRK07764  522 AVPKRSRKTWaillpeATVLGVRGDTLVLGFStGGLARRFASPGNAevlvTALAEELGGDW------------QVEAV-- 587

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  236 hsktpeerslpsdLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHS 315
Cdd:PRK07764  588 -------------VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHP 654

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  316 QLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPE-VLEPHSLDQPPATSPRPLIEV 394
Cdd:PRK07764  655 KHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGqADDPAAQPPQAAQGASAPSPA 734


                  .
gi 110556636  395 G 395
Cdd:PRK07764  735 A 735
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 273-691 7.60e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 7.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  273 PSSPAPSSENGGPASPGLPAEASG----SGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGs 348
Cdd:PRK07764  405 APAAAPAPAAAAPAAAAAPAPAAApqpaPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPA- 483

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  349 rhtPSPGLPAEGAPEAPRPSSPPP----------------EVLEPHSLDQPPATSPRPLieVGELLD--LTRTFPSGGEE 410
Cdd:PRK07764  484 ---PPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilAAVPKRSRKTWAILLPEAT--VLGVRGdtLVLGFSTGGLA 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  411 EAKGDAHlRPTSLVQrrfsegVLqspsqdQEKLGGSLA--ALPQGQGSQLALDRPFGAESNWSLSQSFEWTFPTRPSGlg 488
Cdd:PRK07764  559 RRFASPG-NAEVLVT------AL------AEELGGDWQveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAA-- 623

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  489 vwrldSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGSSWVQGDDPSMSLTQKGDGESQPQFPAVP 568
Cdd:PRK07764  624 -----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP 698

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  569 LEPLPTTEGTPglPLQQAEERYESQEPLAGQESPLPLATREAALPILEPVLGQEQPAAPDQPcvlfADAPEPGQALPVEE 648
Cdd:PRK07764  699 AQPAPAPAATP--PAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP----PPPPAPAPAAAPAA 772

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 110556636  649 EavtlARAETTQARTEAQDLCRASPEPPGPESSSRWLDDLLAS 691
Cdd:PRK07764  773 A----PPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEE 811
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 88-393 1.07e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.47  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   88 QPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASerFAATTVEEILAK 167
Cdd:PHA03307  108 PPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAA--LPLSSPEETARA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  168 MEQPRKEVLASPDRLWGSrltfnHDGSSRYGP-RTYGTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLP 246
Cdd:PHA03307  186 PSSPPAEPPPSTPPAAAS-----PRPPRRSSPiSASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  247 SDLAFNGDLAKAAsselpadiskPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEAS 326
Cdd:PHA03307  261 APITLPTRIWEAS----------GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTS 330

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110556636  327 QASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPevlephsldQPPATSPRPLIE 393
Cdd:PHA03307  331 SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPS---------SPAASAGRPTRR 388
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 230-387 2.35e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 45.85  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  230 AECREEHSKTPEERSLPSDlafnGDLAKAASSELPADIsKPWiPSSPAPSSENGGPASPGLPAEASGSGPGSPhlhPPDK 309
Cdd:PRK08691  400 AETAQTPVQTASAAAMPSE----GKTAGPVSNQENNDV-PPW-EDAPDEAQTAAGTAQTSAKSIQTASEAETP---PENQ 470

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110556636  310 SSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATS 387
Cdd:PRK08691  471 VSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAEPFYGYGFPDNDCPPEDGAEIPPPDWEHAAPADT 548
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 265-393 2.44e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.23  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  265 ADISKPWIPSSPAPSSENG----GPASPGLPAEASGSGPGSPHLHP------PDKSSPCHSQLLEAQTPEASQASPCPAV 334
Cdd:PRK10263  351 VPPAQPTVAWQPVPGPQTGepviAPAPEGYPQQSQYAQPAVQYNEPlqqpvqPQQPYYAPAAEQPAQQPYYAPAPEQPAQ 430

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110556636  335 TPS-APSAALPDEGSR-HTPSPGLPAEGAP------EAPRPSSPPPEVLEPHSLDQPPATSPRPLIE 393
Cdd:PRK10263  431 QPYyAPAPEQPVAGNAwQAEEQQSTFAPQStyqteqTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVE 497
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 237-388 3.20e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 3.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   237 SKTPEERSLPSDLAFNGDLAKAASSELPADISKPW---IPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHP------- 306
Cdd:pfam05109  422 SKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTnltAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngtes 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   307 --PDKSSPCHSQLL-----------------EAQTPEASQASPCPAVTPSAPSAALPDEG-SRHTPSPGLPAEGApeapr 366
Cdd:pfam05109  502 kaPDMTSPTSAVTTptpnatsptpavttptpNATSPTLGKTSPTSAVTTPTPNATSPTPAvTTPTPNATIPTLGK----- 576

                          170       180
                   ....*....|....*....|..
gi 110556636   367 pSSPPPEVLEPhsldQPPATSP 388
Cdd:pfam05109  577 -TSPTSAVTTP----TPNATSP 593
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 295-391 4.06e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.47  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  295 SGSGPGSPhlhppdkSSPCHSQllEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAegAPEAPRPSSPPPEV 374
Cdd:PHA02682   77 SGQSPLAP-------SPACAAP--APACPACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCP--APARPAPACPPSTR 145

                          90
                  ....*....|....*..
gi 110556636  375 LEPHSldqPPATSPRPL 391
Cdd:PHA02682  146 QCPPA---PPLPTPKPA 159
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
242-377 5.11e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  242 ERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQ 321
Cdd:PRK07003  440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASRE 519

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110556636  322 TPEASQASPCPAVTPSAPSAALP----------------------DEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEP 377
Cdd:PRK07003  520 DAPAAAAPPAPEARPPTPAAAAPaaraggaaaaldvlrnagmrvsSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVP 597
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 249-380 8.29e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.32  E-value: 8.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  249 LAF---NGDLAKA-ASSELPADISKPwiPSSPAPSSENGGPASPGLPAEASGSGPGSPhlhPPDKSSPCHSQLLEAQTPE 324
Cdd:PRK14951  362 LAFkpaAAAEAAApAEKKTPARPEAA--APAAAPVAQAAAAPAPAAAPAAAASAPAAP---PAAAPPAPVAAPAAAAPAA 436

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  325 ASQASPCPAVTPSAPSAALPDEGS----RHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSL 380
Cdd:PRK14951  437 APAAAPAAVALAPAPPAQAAPETVaipvRVAPEPAVASAAPAPAAAPAAARLTPTEEGDV 496
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 92-390 8.74e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 8.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   92 GSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPP---PLTPPARCAAPGGVRKAPAPFRPASERFAATTVEEILAKM 168
Cdd:PHA03307   73 PGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPgpsSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASP 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  169 EQPRKEVLASPDRLWGSRltfnhdGSSRYGPRTYGTTTAPrdedgstlfrgwSQEGPVKSPAECREEHSKTPEERSLP-S 247
Cdd:PHA03307  153 PAAGASPAAVASDAASSR------QAALPLSSPEETARAP------------SSPPAEPPPSTPPAAASPRPPRRSSPiS 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  248 DLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQlleAQTPEASQ 327
Cdd:PHA03307  215 ASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPG---PASSSSSP 291

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110556636  328 ASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHS--LDQPPATSPRP 390
Cdd:PHA03307  292 RERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPgpSPSRSPSPSRP 356
PHA03247 PHA03247
large tegument protein UL36; Provisional
 273-693 9.33e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 9.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  273 PSSPAPSSENGGPASPGLPAEASGSGPGSPHLHP---PDKS--SPCHSQLLE-----AQTPEASQASPCPAVTPSAPSAA 342
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPailPDEPvgEPVHPRMLTwirglEELASDDAGDPPPPLPPAAPPAA 2563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  343 lPDEG---SRHTPSPGLPAEGAPEA---------------------PRPSSPPPEVLEPHSLDqPPATSPRPLIEVGELL 398
Cdd:PHA03247 2564 -PDRSvppPRPAPRPSEPAVTSRARrpdappqsarprapvddrgdpRGPAPPSPLPPDTHAPD-PPPPSPSPAANEPDPH 2641

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  399 DLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQSPSQDQEKLG-----GSLAAL-----------PQGQGSQLALDR 462
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvGSLTSLadpppppptpePAPHALVSATPL 2721

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  463 PFGAESNWSLSQSFEWTF--PTRPSGLGVWRLDSPPPSPITEASEAAEAAEAGNLAVSSREEGVSQQGQGAGSAPSGSGS 540
Cdd:PHA03247 2722 PPGPAAARQASPALPAAPapPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP 2801

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  541 SwvQGDDPSMSLTQKGDGESQPQFPAVPLEP----LPTTEGTPGLPLQQAE-------------ERYESQEPLAGQESPL 603
Cdd:PHA03247 2802 W--DPADPPAAVLAPAAALPPAASPAGPLPPptsaQPTAPPPPPGPPPPSLplggsvapggdvrRRPPSRSPAAKPAAPA 2879

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  604 PLATREAALPILEP-----VLGQEQPAAPDQPcvlfaDAPEPGQALPVEEEAVTLARAETTQARTEAQDLCRASPEPPGP 678
Cdd:PHA03247 2880 RPPVRRLARPAVSRstesfALPPDQPERPPQP-----QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGE 2954

                         490
                  ....*....|....*
gi 110556636  679 ESSSRWLDDLLASPP 693
Cdd:PHA03247 2955 PSGAVPQPWLGALVP 2969
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
256-390 1.08e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  256 AKAASSELPADISKPWIPSSPAPSSenggPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVT 335
Cdd:PRK12323  386 APAAAAPAAAAPAPAAPPAAPAAAP----AAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA 461

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 110556636  336 PSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRP 390
Cdd:PRK12323  462 ARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDA 516
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 273-382 1.38e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 42.54  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  273 PSSPAPSSENGGPASPGL------PAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAV-TPSAPSAALPD 345
Cdd:PHA02682   86 PACAAPAPACPACAPAAPapavtcPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLpTPKPAPAAKPI 165

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 110556636  346 EGSRHTPSPGLPAEGAPEAPRPSSPPPeVLEPHSLDQ 382
Cdd:PHA02682  166 FLHNQLPPPDYPAASCPTIETAPAASP-VLEPRIPDK 201
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 288-400 1.39e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  288 PGLPAEASGSGPGSPhLHPPDKSSPCHSQLLEAQTPEASQASPC---------PAVTPSAPSAALPDEGSRHTPSPGL-- 356
Cdd:PRK14951  366 PAAAAEAAAPAEKKT-PARPEAAAPAAAPVAQAAAAPAPAAAPAaaasapaapPAAAPPAPVAAPAAAAPAAAPAAAPaa 444

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 110556636  357 ----PAEGAPEAPRPSSPPPEVL-EPHSLDQPPATSPRP---LIEVGELLDL 400
Cdd:PRK14951  445 valaPAPPAQAAPETVAIPVRVApEPAVASAAPAPAAAPaaaRLTPTEEGDV 496
dnaA PRK14086
chromosomal replication initiator protein DnaA;
244-390 1.44e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 43.28  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  244 SLPSDLA---FNGDLAKAASSELPADISKPWIPSSPAPSSenGGPASPGLPAEASGSGPGSPHlhPPDKSSPCHSQllea 320
Cdd:PRK14086   52 AVPNEFAkevLEGRLAPIISETLSRELGRPIRIAITVDPS--AGEPAPPPPHARRTSEPELPR--PGRRPYEGYGG---- 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 110556636  321 qtPEASQASPCPAVTPSAPSA--ALPDEGSRHTPS--PGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRP 390
Cdd:PRK14086  124 --PRADDRPPGLPRQDQLPTArpAYPAYQQRPEPGawPRAADDYGWQQQRLGFPPRAPYASPASYAPEQERDRE 195
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 205-424 1.49e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 43.38  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  205 TTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSK-----TPEERSLPSDLAFNGDLAKAASSELPA---DISKPwiPSSP 276
Cdd:PLN03209  309 TTAPLTPMEELLAKIPSQRVPPKESDAADGPKPVptkpvTPEAPSPPIEEEPPQPKAVVPRPLSPYtayEDLKP--PTSP 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  277 APSSENGGPASPGlPAEASgSGPGSPHLHPPDKSSPCHSQLLEAQTPEASQ---------------ASPCP-AVTPSAPS 340
Cdd:PLN03209  387 IPTPPSSSPASSK-SVDAV-AKPAEPDVVPSPGSASNVPEVEPAQVEAKKTrplspyaryedlkppTSPSPtAPTGVSPS 464

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  341 AALPDEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLIEVGelldltRTFPSGGEEEAKGDAHLRP 420
Cdd:PLN03209  465 VSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVG------KVAPSSTNEVVKVGNSAPP 538


                  ....
gi 110556636  421 TSLV 424
Cdd:PLN03209  539 TALA 542
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
81-382 2.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   81 MNMLA-GPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAPAPFRPASERFAA- 158
Cdd:PRK07003  353 LRMLAfEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAp 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  159 -TTVEEILAKMEQPRKEVLASPDRLwgsrltfnhDGSSRYGPRTYGTTTAPRDEDGSTlfrgwsqeGPVKSPAecreehs 237
Cdd:PRK07003  433 pATADRGDDAADGDAPVPAKANARA---------SADSRCDERDAQPPADSGSASAPA--------SDAPPDA------- 488

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  238 ktPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLH---------PPD 308
Cdd:PRK07003  489 --AFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDvlrnagmrvSSD 566

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110556636  309 KSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSP----PPEVLEPHSLDQ 382
Cdd:PRK07003  567 RGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPwediPPDDYVPLSADE 644
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
300-434 3.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  300 GSPHLHPPDKSSPCHSQLLEAQTP---EASQASPCPAVTPSAPSAALPDEGSRHTPSPG-LPAEGAPEAPRPSSPPPEVL 375
Cdd:PRK14971  369 ASGGRGPKQHIKPVFTQPAAAPQPsaaAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVsVDPPAAVPVNPPSTAPQAVR 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 110556636  376 EPhsldQPPATSPRPLIEVGELLDLTRTFPSGGEEEAKGDAHLRPTSLVQRRFSEGVLQ 434
Cdd:PRK14971  449 PA----QFKEEKKIPVSKVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQKEIFTEEDLQ 503
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 273-390 4.64e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 4.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   273 PSSPAPSSENGGPASPGLPAEASGSGP-GSPHLHPPDKSSPCHSQLLEAQTPEASQASPCPAVTPSAPSAALPDEGSrht 351
Cdd:pfam03154  423 QLPPPPAQPPVLTQSQSLPPPAASHPPtSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSAS--- 499

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 110556636   352 PSPGLPAEGAPEAPRP-----SSPPPEVLEPHSlDQPPATSPRP 390
Cdd:pfam03154  500 VSSSGPVPAAVSCPLPpvqikEEALDEAEEPES-PPPPPRSPSP 542
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 77-388 5.27e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 5.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636    77 SARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLT--PPARCAAPGG------------V 142
Cdd:pfam03154  160 SSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATsqPPNQTQSTAAphtliqqtptlhP 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   143 RKAPAPFRPASERFAATTVEEILAKMEQP---RKEVLASPDRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRG 219
Cdd:pfam03154  240 QRLPSPHPPLQPMTQPPPPSQVSPQPLPQpslHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPG 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   220 WSQEGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPA-----DISKPWIPSSPAPSSENGG-PASPGLPAE 293
Cdd:pfam03154  320 QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQlpnpqSHKHPPHLSGPSPFQMNSNlPPPPALKPL 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   294 ASGSGPGSPHLHPPDKSSPCHSQLLE---AQTPEASQASPCPAVTPSAPSAALPDEGSRHTPSPGLP--AEGAPEAPRPS 368
Cdd:pfam03154  400 SSLSTHHPPSAHPPPLQLMPQSQQLPpppAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPS 479

                          330       340
                   ....*....|....*....|
gi 110556636   369 SPPPEVLEPHSLDQPPATSP 388
Cdd:pfam03154  480 GPPTSTSSAMPGIQPPSSAS 499
PHA03247 PHA03247
large tegument protein UL36; Provisional
 10-374 5.36e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   10 SAMASPLPREMEEELVPTGSEPGDTRAKPPVKPKPR--ALPAKPALPA---------------KPSLLVPVGPRPPRGPL 72
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQAspALPAAPAPPAvpagpatpggparpaRPPTTAGPPAPAPPAAP 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636   73 AELPSARKMNMLAGPQPYGGSKRPLPFAPRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAPGGVRKAP------ 146
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSlplggs 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  147 -APFRPASERFAATTVEEILAKMEQPRKEVLASPdRLWGSRLTFNHDGSSRYGPRTYGTTTAPRDEDGSTLFRGWSQEGP 225
Cdd:PHA03247 2856 vAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  226 VKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPA---DISKPwIPSSPAPSSENGGPASPGLPA---------- 292
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVprfRVPQP-APSREAPASSTPPLTGHSLSRvsswasslal 3013

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  293 -EASGSGPGS--PHLHPPDKSSPCHSQLLEAQTPEASQASpcpAVTPSAPSAALPdegSRHTPSPGLPAEGAPEAPRPSS 369
Cdd:PHA03247 3014 hEETDPPPVSlkQTLWPPDDTEDSDADSLFDSDSERSDLE---ALDPLPPEPHDP---FAHEPDPATPEAGARESPSSQF 3087


                  ....*
gi 110556636  370 PPPEV 374
Cdd:PHA03247 3088 GPPPL 3092
PHA03247 PHA03247
large tegument protein UL36; Provisional
 100-330 6.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  100 APRPAVEASTGGEATQETGKEEAGKEEPPPLTPPARCAAP------GGVRKAPAPFRPASERFAATTVEEILAKMEQPRK 173
Cdd:PHA03247  254 APAPPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPpdgvwgAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGA 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  174 EVLASPdrLWGSRLTFNHDGSSRYGPrtygTTTAPRDEDGSTLFRGWSQEGPVKSPAECREEHSKTPEERSLPSDLAFNG 253
Cdd:PHA03247  334 MEVVSP--LPRPRQHYPLGFPKRRRP----TWTPPSSLEDLSAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRP 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  254 DLAKAASSELPADI----SKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHP-PDKSSP-CHSQLLEAQTPEASQ 327
Cdd:PHA03247  408 AAPVPASVPTPAPTpvpaSAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDdPDDATRkALDALRERRPPEPPG 487


                  ...
gi 110556636  328 ASP 330
Cdd:PHA03247  488 ADL 490
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
257-385 6.94e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110556636  257 KAASSELPADISKPWIPSSPAPSSENG-GPASPGLPAEASGSGPGSPHLHPPDKSSpchsqllEAQTPEASQASPCPAVT 335
Cdd:PRK07003  413 KAAAAAAATRAEAPPAAPAPPATADRGdDAADGDAPVPAKANARASADSRCDERDA-------QPPADSGSASAPASDAP 485

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 110556636  336 PSAPSAALP--DEGSRHTPSPGLPAEGAPEAPRPSSPPPEVlEPHSLDQPPA 385
Cdd:PRK07003  486 PDAAFEPAPraAAPSAATPAAVPDARAPAAASREDAPAAAA-PPAPEARPPT 536
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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