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Conserved domains on  [gi|255767016|ref|NP_387904|]
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inhibitor of the pro-sigma(K) processing machinery [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

pro-sigmaK processing inhibitor BofA family protein( domain architecture ID 10021549)

pro-sigmaK processing inhibitor BofA family protein similar to Bacillus subtilis sigma-K factor-processing regulatory protein BofA that is involved in the mediation of the intercompartmental coupling of pro-sigma K processing to events in the forespore

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
spore_BofA TIGR02862
pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in ...
 20-86 4.69e-13

pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination]


:

Pssm-ID: 163046  Cd Length: 83  Bit Score: 58.45  E-value: 4.69e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255767016  20 SGSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFI 86
Cdd:TIGR02862 17 VGAPVKPLRLIGKAAINLIIGALLLFIVNVFGGAFGIHIPINLVTATIAGFLGLPGIALLVAIKLFI 83
 
Name Accession Description Interval E-value
spore_BofA TIGR02862
pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in ...
 20-86 4.69e-13

pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination]


Pssm-ID: 163046  Cd Length: 83  Bit Score: 58.45  E-value: 4.69e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255767016  20 SGSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFI 86
Cdd:TIGR02862 17 VGAPVKPLRLIGKAAINLIIGALLLFIVNVFGGAFGIHIPINLVTATIAGFLGLPGIALLVAIKLFI 83
BofA COG5848
SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, ...
 20-87 2.95e-12

SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444550  Cd Length: 88  Bit Score: 56.72  E-value: 2.95e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255767016 20 SGSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII 87
Cdd:COG5848  21 GGALLKPLKWLGKLILNLLIGALLLFLVNLFGGFFGFHIPINPVTALIAGFLGLPGVALLVVLKLFLL 88
BofA pfam07441
SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor ...
 21-83 2.24e-08

SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.


Pssm-ID: 462165  Cd Length: 73  Bit Score: 46.28  E-value: 2.24e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255767016  21 GSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIK 83
Cdd:pfam07441 11 KVLKKPLKLLLKLVINAVLGLVLLFLVNLLGAFFGFHIPINPVTALIAGILGIPGVILLLLLK 73
 
Name Accession Description Interval E-value
spore_BofA TIGR02862
pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in ...
 20-86 4.69e-13

pro-sigmaK processing inhibitor BofA; Members of this protein family are found only in endospore-forming bacteria, such as Bacillus subtilis and Clostridium tetani. Among such bacteria, it appears only Symbiobacterium thermophilum lacks a member of this family. The protein, designated BofA, is an integral membrane protein that regulates the proteolytic activation of the RNA polymerase sigma factor K. [Cellular processes, Sporulation and germination]


Pssm-ID: 163046  Cd Length: 83  Bit Score: 58.45  E-value: 4.69e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 255767016  20 SGSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFI 86
Cdd:TIGR02862 17 VGAPVKPLRLIGKAAINLIIGALLLFIVNVFGGAFGIHIPINLVTATIAGFLGLPGIALLVAIKLFI 83
BofA COG5848
SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, ...
 20-87 2.95e-12

SigmaK-processing regulatory protein BofA (Bypass-of-forespore protein A) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444550  Cd Length: 88  Bit Score: 56.72  E-value: 2.95e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 255767016 20 SGSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII 87
Cdd:COG5848  21 GGALLKPLKWLGKLILNLLIGALLLFLVNLFGGFFGFHIPINPVTALIAGFLGLPGVALLVVLKLFLL 88
BofA pfam07441
SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor ...
 21-83 2.24e-08

SigmaK-factor processing regulatory protein BofA; This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein.


Pssm-ID: 462165  Cd Length: 73  Bit Score: 46.28  E-value: 2.24e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255767016  21 GSAAKPLKWIGITAVKFVAGALLLVCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIK 83
Cdd:pfam07441 11 KVLKKPLKLLLKLVINAVLGLVLLFLVNLLGAFFGFHIPINPVTALIAGILGIPGVILLLLLK 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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