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Conserved domains on  [gi|16554585|ref|NP_438171|]
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coronin-2A [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-518 3.65e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 300.66  E-value: 3.65e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   10 SKFRHVFGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   88 VKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKES 167
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  168 VitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEA-SYKGHRASKVLFLGNLKKLMSTGTSRWN 246
Cdd:PTZ00421 161 V-----EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVeAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  247 NRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKphLSYLTEYRSYNPQKGIGVMP 326
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  327 KRGLDVSSCEIFRFYKLiTTKSLIePISMIVPRRS--ESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLrpgsell 404
Cdd:PTZ00421 314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM------- 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  405 rphplpaeRPIFNSMapaSPRLLNQTEklAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTEN--- 481
Cdd:PTZ00421 385 --------SAVFDGT---SPELMGASA--LSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILder 451

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 16554585  482 -----ELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNL 518
Cdd:PTZ00421 452 lgrlqALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-518 3.65e-96

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 300.66  E-value: 3.65e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   10 SKFRHVFGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   88 VKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKES 167
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  168 VitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEA-SYKGHRASKVLFLGNLKKLMSTGTSRWN 246
Cdd:PTZ00421 161 V-----EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVeAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  247 NRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKphLSYLTEYRSYNPQKGIGVMP 326
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  327 KRGLDVSSCEIFRFYKLiTTKSLIePISMIVPRRS--ESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLrpgsell 404
Cdd:PTZ00421 314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM------- 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  405 rphplpaeRPIFNSMapaSPRLLNQTEklAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTEN--- 481
Cdd:PTZ00421 385 --------SAVFDGT---SPELMGASA--LSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILder 451

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 16554585  482 -----ELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNL 518
Cdd:PTZ00421 452 lgrlqALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 7-70 5.99e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.30  E-value: 5.99e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16554585     7 YRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGK 70
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-306 1.82e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.82e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  79 CGHRGNVLDVKWNPFDDFeIASCSEDATIKIWSIPKQLLTRnltayrkELVGHARRVGLVEWHPTAaNILFSAGYDYKVM 158
Cdd:cd00200  48 KGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 159 IWNLDTKESVITspmstISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQeaSYKGHRAS--KVLFLGNLKK 236
Cdd:cd00200 119 VWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGEvnSVAFSPDGEK 191

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16554585 237 LMSTGtsrwNNRQVALWDQDNLSVP-LMEEDLDGSSGVLFpfydADTSMLYVVGKGDGNIRYYEVSADKPH 306
Cdd:cd00200 192 LLSSS----SDGTIKLWDLSTGKCLgTLRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
80-305 5.24e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 5.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPfDDFEIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAaNILFSAGYDYKVMI 159
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPDG-KLLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 160 WNLDTKEsvitsPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMS 239
Cdd:COG2319 231 WDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16554585 240 TGtsrwNNRQVALWD-QDNLSVPLMEEDLDGSSGVLFpfyDADTSMLyVVGKGDGNIRYYEVSADKP 305
Cdd:COG2319 306 GS----DDGTVRLWDlATGKLLRTLTGHTGAVRSVAF---SPDGKTL-ASGSDDGTVRLWDLATGEL 364
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-111 2.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.88e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 16554585     80 GHRGNVLDVKWNPFDDFeIASCSEDATIKIWS 111
Cdd:smart00320  10 GHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 10-518 3.65e-96

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 300.66  E-value: 3.65e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   10 SKFRHVFGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   88 VKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKES 167
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  168 VitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEA-SYKGHRASKVLFLGNLKKLMSTGTSRWN 246
Cdd:PTZ00421 161 V-----EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVeAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  247 NRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKphLSYLTEYRSYNPQKGIGVMP 326
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  327 KRGLDVSSCEIFRFYKLiTTKSLIePISMIVPRRS--ESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLrpgsell 404
Cdd:PTZ00421 314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM------- 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  405 rphplpaeRPIFNSMapaSPRLLNQTEklAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTEN--- 481
Cdd:PTZ00421 385 --------SAVFDGT---SPELMGASA--LSPSGKPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILder 451

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 16554585  482 -----ELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNL 518
Cdd:PTZ00421 452 lgrlqALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
PTZ00420 PTZ00420
coronin; Provisional
 19-402 6.36e-66

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 223.29  E-value: 6.36e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   19 PASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKlDPHYPKVCGHRGNVLDVKWNPFDDFEI 98
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR-KPPVIKLKGHTSSILDLQFNPCFSEIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   99 ASCSEDATIKIWSIPKQllTRNLTAYRKE---LVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMST 175
Cdd:PTZ00420  91 ASGSEDLTIRVWEIPHN--DESVKEIKDPqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  176 ischqdVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEAS-YKGHRASKVLFL----GNLKKLMSTGTSRWNNRQV 250
Cdd:PTZ00420 169 ------KLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHiHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  251 ALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKphLSYLTEYRSYNPQKGIGVMPKRGL 330
Cdd:PTZ00420 243 KLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQIC 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16554585  331 DVSSCEIFRFYKlITTKSLIEPISMIVPRRSES-YQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSE 402
Cdd:PTZ00420 321 DVYKCEIGRVYK-NENNSSIRPISFYVPRKNPTkFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKDLTE 392
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 7-70 5.99e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.30  E-value: 5.99e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16554585     7 YRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGK 70
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-306 1.82e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.82e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  79 CGHRGNVLDVKWNPFDDFeIASCSEDATIKIWSIPKQLLTRnltayrkELVGHARRVGLVEWHPTAaNILFSAGYDYKVM 158
Cdd:cd00200  48 KGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 159 IWNLDTKESVITspmstISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQeaSYKGHRAS--KVLFLGNLKK 236
Cdd:cd00200 119 VWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGEvnSVAFSPDGEK 191

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16554585 237 LMSTGtsrwNNRQVALWDQDNLSVP-LMEEDLDGSSGVLFpfydADTSMLYVVGKGDGNIRYYEVSADKPH 306
Cdd:cd00200 192 LLSSS----SDGTIKLWDLSTGKCLgTLRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGECV 254
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-309 7.82e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 7.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPFDDFeIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPtAANILFSAGYDYKVMI 159
Cdd:cd00200   7 GHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASA-DGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 160 WNLDTKESVitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTvlQEASYKGHRAS--KVLFLGNlKKL 237
Cdd:cd00200  78 WDLETGECV-----RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWvnSVAFSPD-GTF 149

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16554585 238 MSTGtsrWNNRQVALWDQDNLSVplmEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKPHLSY 309
Cdd:cd00200 150 VASS---SQDGTIKLWDLRTGKC---VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215
WD40 COG2319
WD40 repeat [General function prediction only];
80-305 5.24e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 5.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPfDDFEIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAaNILFSAGYDYKVMI 159
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPDG-KLLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 160 WNLDTKEsvitsPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMS 239
Cdd:COG2319 231 WDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16554585 240 TGtsrwNNRQVALWD-QDNLSVPLMEEDLDGSSGVLFpfyDADTSMLyVVGKGDGNIRYYEVSADKP 305
Cdd:COG2319 306 GS----DDGTVRLWDlATGKLLRTLTGHTGAVRSVAF---SPDGKTL-ASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-254 1.52e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 1.52e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPFDDFeIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAANILFSAGyDYKVMI 159
Cdd:cd00200 133 GHTDWVNSVAFSPDGTF-VASSSQDGTIKLWDLRTGKCVATLT-------GHTGEVNSVAFSPDGEKLLSSSS-DGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 160 WNLDTKESVitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEasYKGHRAS--KVLFLGNLKKL 237
Cdd:cd00200 204 WDLSTGKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT--LSGHTNSvtSLAWSPDGKRL 276

                       170
                ....*....|....*..
gi 16554585 238 MSTGTsrwnNRQVALWD 254
Cdd:cd00200 277 ASGSA----DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
80-254 3.37e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 3.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPfDDFEIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAaNILFSAGYDYKVMI 159
Cdd:COG2319 244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT-------GHSGGVNSVAFSPDG-KLLASGSDDGTVRL 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 160 WNLDTKEsvitsPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEasYKGHRAS--KVLFLGNLKKL 237
Cdd:COG2319 315 WDLATGK-----LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT--LTGHTGAvtSVAFSPDGRTL 387

                       170
                ....*....|....*..
gi 16554585 238 MSTGtsrwNNRQVALWD 254
Cdd:COG2319 388 ASGS----ADGTVRLWD 400
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 350-392 5.65e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 82.95  E-value: 5.65e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16554585   350 IEPISMIVPRRS-ESYQEDIYPPTAGAQPSLTAQEWLSGMNRDP 392
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
80-254 1.86e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.50  E-value: 1.86e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPfDDFEIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAaNILFSAGYDYKVMI 159
Cdd:COG2319  76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLT-------GHTGAVRSVAFSPDG-KTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 160 WNLDTKESVitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQeaSYKGHRAS--KVLFLGNLKKL 237
Cdd:COG2319 147 WDLATGKLL-----RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--TLTGHTGAvrSVAFSPDGKLL 219

                       170
                ....*....|....*..
gi 16554585 238 MSTGtsrwNNRQVALWD 254
Cdd:COG2319 220 ASGS----ADGTVRLWD 232
WD40 COG2319
WD40 repeat [General function prediction only];
80-210 2.10e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 2.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPfDDFEIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAaNILFSAGYDYKVMI 159
Cdd:COG2319 286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPDG-KTLASGSDDGTVRL 356

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 16554585 160 WNLDTKEsvitsPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPR 210
Cdd:COG2319 357 WDLATGE-----LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
80-164 4.13e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 4.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  80 GHRGNVLDVKWNPFDDFeIASCSEDATIKIWSIPKQLLTRNLTayrkelvGHARRVGLVEWHPTAaNILFSAGYDYKVMI 159
Cdd:COG2319 328 GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLT-------GHTGAVTSVAFSPDG-RTLASGSADGTVRL 398


                ....*
gi 16554585 160 WNLDT 164
Cdd:COG2319 399 WDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-305 2.83e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 2.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585 175 TISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLqeASYKGHRAS--KVLFLGNLKKLMSTGtsrwNNRQVAL 252
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL--RTLKGHTGPvrDVAASADGTYLASGS----SDKTIRL 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 16554585 253 WDQDNLSVPlmeEDLDG-SSGVLFPFYDADTSMLyVVGKGDGNIRYYEVSADKP 305
Cdd:cd00200  78 WDLETGECV---RTLTGhTSYVSSVAFSPDGRIL-SSSSRDKTIKVWDVETGKC 127
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-111 2.88e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.88e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 16554585     80 GHRGNVLDVKWNPFDDFeIASCSEDATIKIWS 111
Cdd:smart00320  10 GHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 171-208 3.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 16554585    171 SPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVID 208
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
80-111 1.38e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.38e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16554585    80 GHRGNVLDVKWNPFDDFeIASCSEDATIKIWS 111
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
171-208 1.91e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.91e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 16554585   171 SPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVID 208
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 72-254 6.30e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 6.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585   72 DPHYPKV-CGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPK-QLLTrnltayrkELVGHARRVGLVEWHPTAANILF 149
Cdd:PLN00181 521 DIHYPVVeLASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARsQLVT--------EMKEHEKRVWSIDYSSADPTLLA 592

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16554585  150 SAGYDYKVMIWNLDTKESVitspmSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRaGTVLQEASYKGHR--ASK 227
Cdd:PLN00181 593 SGSDDGSVKLWSINQGVSI-----GTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLR-NPKLPLCTMIGHSktVSY 666

                        170       180
                 ....*....|....*....|....*..
gi 16554585  228 VLFLGNlkklmSTGTSRWNNRQVALWD 254
Cdd:PLN00181 667 VRFVDS-----STLVSSSTDNTLKLWD 688
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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