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Conserved domains on  [gi|153791192|ref|NP_543016|]
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isthmin-1 precursor [Homo sapiens]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 11259316)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMOP smart00723
Adhesion-associated domain present in MUC4 and other proteins;
289-452 8.04e-47

Adhesion-associated domain present in MUC4 and other proteins;


:

Pssm-ID: 128962  Cd Length: 154  Bit Score: 158.91  E-value: 8.04e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192   289 LFEVDTDSCERWMSCKSEFLKkYMHkVMNDLPSCPCSYPTEVAYStadifdrikrKDFRWKDASGPKEK-LEIYKPTARY 367
Cdd:smart00723   1 ERPWDRDMCLRWLECDGQLPN-FLW-DLEDLPSCPCSLPQAVADS----------GRFRPDDACDPDERiLCTYHPGARH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192   368 CIRSMLSLESTtLAAQHCCYGDNMQLIT----------RGKGAGTPNLI-STEFSAELHYKVDVLPWIICKGDWSRYnea 436
Cdd:smart00723  69 CIRSMQSVEST-GAGQVCCYDAWGQLMTtddqpvikprRGHGAGTPPYIgSTEVPGLSHFKNDVEPYILCCKWADRP--- 144

                          170
                   ....*....|....*.
gi 153791192   437 rppnngQKCTESPSDE 452
Cdd:smart00723 145 ------QRCTMYYWRR 154
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 221-262 1.33e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 1.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 153791192   221 GDWSLWSVCSVTCGNGNQKRTRSC--------GYACT--ATESRTCDRPNCP 262
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCcspppqngGGPCTgeDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
AMOP smart00723
Adhesion-associated domain present in MUC4 and other proteins;
289-452 8.04e-47

Adhesion-associated domain present in MUC4 and other proteins;


Pssm-ID: 128962  Cd Length: 154  Bit Score: 158.91  E-value: 8.04e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192   289 LFEVDTDSCERWMSCKSEFLKkYMHkVMNDLPSCPCSYPTEVAYStadifdrikrKDFRWKDASGPKEK-LEIYKPTARY 367
Cdd:smart00723   1 ERPWDRDMCLRWLECDGQLPN-FLW-DLEDLPSCPCSLPQAVADS----------GRFRPDDACDPDERiLCTYHPGARH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192   368 CIRSMLSLESTtLAAQHCCYGDNMQLIT----------RGKGAGTPNLI-STEFSAELHYKVDVLPWIICKGDWSRYnea 436
Cdd:smart00723  69 CIRSMQSVEST-GAGQVCCYDAWGQLMTtddqpvikprRGHGAGTPPYIgSTEVPGLSHFKNDVEPYILCCKWADRP--- 144

                          170
                   ....*....|....*.
gi 153791192   437 rppnngQKCTESPSDE 452
Cdd:smart00723 145 ------QRCTMYYWRR 154
AMOP pfam03782
AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after ...
 293-433 1.34e-34

AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.


Pssm-ID: 461048  Cd Length: 143  Bit Score: 126.32  E-value: 1.34e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192  293 DTDSCERWMSCKsEFLKKYMHkvmnDLPSCPCSYPTEVAystaDI--FDRIKRKDFRWkdasGPKEKLEiYKPTARYCIR 370
Cdd:pfam03782   1 AHDMCDNWYNCD-RFLKNFLA----ELPSCPCTLPQALL----DKgrFMPDPRCDLDW----NPKETCT-YHPGAVHCVR 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 153791192  371 SMLSLESttLAAQHCCYGDNMQLI-----------TRGKGAGTPNLISTEFSAEL-HYKVDVLPWIICK----GDWSRY 433
Cdd:pfam03782  67 SGLPSFS--GSGQQCCYDDDGYLMltydsfwgstpDRGHDWGAPPYRSPPFVPGLsHWLHDVMPFYYCClwadEDCERY 143
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 221-262 1.33e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 1.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 153791192   221 GDWSLWSVCSVTCGNGNQKRTRSC--------GYACT--ATESRTCDRPNCP 262
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCcspppqngGGPCTgeDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
221-261 3.31e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 3.31e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 153791192  221 GDWSLWSVCSVTCGNGNQKRTRSC------GYACTA--TESRTCDRPNC 261
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpgGEPCTGddIETQACKMDKC 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 221-262 4.09e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 4.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 153791192 221 GDWSLWSVCSVTCGNGNQKRTRSCGYA-CTATESRTCDRPNCP 262
Cdd:PTZ00441 241 GPWDEWTPCSVTCGKGTHSRSRPILHEgCTTHMVEECEEEECP 283
 
Name Accession Description Interval E-value
AMOP smart00723
Adhesion-associated domain present in MUC4 and other proteins;
289-452 8.04e-47

Adhesion-associated domain present in MUC4 and other proteins;


Pssm-ID: 128962  Cd Length: 154  Bit Score: 158.91  E-value: 8.04e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192   289 LFEVDTDSCERWMSCKSEFLKkYMHkVMNDLPSCPCSYPTEVAYStadifdrikrKDFRWKDASGPKEK-LEIYKPTARY 367
Cdd:smart00723   1 ERPWDRDMCLRWLECDGQLPN-FLW-DLEDLPSCPCSLPQAVADS----------GRFRPDDACDPDERiLCTYHPGARH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192   368 CIRSMLSLESTtLAAQHCCYGDNMQLIT----------RGKGAGTPNLI-STEFSAELHYKVDVLPWIICKGDWSRYnea 436
Cdd:smart00723  69 CIRSMQSVEST-GAGQVCCYDAWGQLMTtddqpvikprRGHGAGTPPYIgSTEVPGLSHFKNDVEPYILCCKWADRP--- 144

                          170
                   ....*....|....*.
gi 153791192   437 rppnngQKCTESPSDE 452
Cdd:smart00723 145 ------QRCTMYYWRR 154
AMOP pfam03782
AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after ...
 293-433 1.34e-34

AMOP domain; This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.


Pssm-ID: 461048  Cd Length: 143  Bit Score: 126.32  E-value: 1.34e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153791192  293 DTDSCERWMSCKsEFLKKYMHkvmnDLPSCPCSYPTEVAystaDI--FDRIKRKDFRWkdasGPKEKLEiYKPTARYCIR 370
Cdd:pfam03782   1 AHDMCDNWYNCD-RFLKNFLA----ELPSCPCTLPQALL----DKgrFMPDPRCDLDW----NPKETCT-YHPGAVHCVR 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 153791192  371 SMLSLESttLAAQHCCYGDNMQLI-----------TRGKGAGTPNLISTEFSAEL-HYKVDVLPWIICK----GDWSRY 433
Cdd:pfam03782  67 SGLPSFS--GSGQQCCYDDDGYLMltydsfwgstpDRGHDWGAPPYRSPPFVPGLsHWLHDVMPFYYCClwadEDCERY 143
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 221-262 1.33e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 1.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 153791192   221 GDWSLWSVCSVTCGNGNQKRTRSC--------GYACT--ATESRTCDRPNCP 262
Cdd:smart00209   2 SEWSEWSPCSVTCGGGVQTRTRSCcspppqngGGPCTgeDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
221-261 3.31e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 3.31e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 153791192  221 GDWSLWSVCSVTCGNGNQKRTRSC------GYACTA--TESRTCDRPNC 261
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpgGEPCTGddIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 221-261 8.93e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.43  E-value: 8.93e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 153791192  221 GDWSLWSVCSVTCGNGNQKRTRSC-------GYACTA-TESRTCDRPNC 261
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVivepqngGRPCPElLERRPCNLPPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 226-261 1.60e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 39.36  E-value: 1.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 153791192  226 WSVCSVTCGNGNQKRTRSC----------GYACTA----TESRTCDRPNC 261
Cdd:pfam19030   6 WGECSVTCGGGVQTRLVQCvqkgggsivpDSECSAqkkpPETQSCNLKPC 55
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 221-262 4.09e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.64  E-value: 4.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 153791192 221 GDWSLWSVCSVTCGNGNQKRTRSCGYA-CTATESRTCDRPNCP 262
Cdd:PTZ00441 241 GPWDEWTPCSVTCGKGTHSRSRPILHEgCTTHMVEECEEEECP 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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