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Conserved domains on  [gi|2000186022|ref|NP_543184|]
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solute carrier family 28 member 3 [Rattus norvegicus]

Protein Classification

NupC/NupG family nucleoside CNT transporter( domain architecture ID 11489677)

NupC/NupG family nucleoside CNT transporter such as nucleoside permease NupC, which transports nucleosides with a high affinity except guanosine and deoxyguanosine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
218-629 1.40e-158

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


:

Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 463.70  E-value: 1.40e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 218 LISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYT 297
Cdd:TIGR00804   1 LISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 298 D--HFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKS 375
Cdd:TIGR00804  81 QdlFVFAFQVLPIIIFFSALISILYYLGIMQWVIRKIGWFLQKAMGTTKLESFSAAANIFLGQTEAPLVIRPYLGDMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 376 ELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDsRNLLEAATQ 455
Cdd:TIGR00804 161 ELFTVMTSGMATIAGSVLGAYISMGVPATYLIAASVMAAPCALAFAKLIYPEVEESKEKSEEDVKLEEGD-QNFFEAASN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 456 GASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFN 535
Cdd:TIGR00804 240 GALAGVKVVANVAAMLIAFVALLALINGILSWVGGWVGYGGLSFQLIFGYVFRPLAFLMGVPWSDAPLVAQLMGTKLAVN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 536 EFVAYEHLSKFINLRKaagpkfvngvqqYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAG 615
Cdd:TIGR00804 320 EFVAYLDLSQYLQTRL------------WLSPKTEAIITFALCGFANFSSIGIILGGLGSLVPKRKSVISRLVLRALCAG 387
                         410
                  ....*....|....
gi 2000186022 616 TIACFMTACIAGML 629
Cdd:TIGR00804 388 TLVSLMSATIAGLY 401
 
Name Accession Description Interval E-value
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
218-629 1.40e-158

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 463.70  E-value: 1.40e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 218 LISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYT 297
Cdd:TIGR00804   1 LISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 298 D--HFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKS 375
Cdd:TIGR00804  81 QdlFVFAFQVLPIIIFFSALISILYYLGIMQWVIRKIGWFLQKAMGTTKLESFSAAANIFLGQTEAPLVIRPYLGDMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 376 ELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDsRNLLEAATQ 455
Cdd:TIGR00804 161 ELFTVMTSGMATIAGSVLGAYISMGVPATYLIAASVMAAPCALAFAKLIYPEVEESKEKSEEDVKLEEGD-QNFFEAASN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 456 GASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFN 535
Cdd:TIGR00804 240 GALAGVKVVANVAAMLIAFVALLALINGILSWVGGWVGYGGLSFQLIFGYVFRPLAFLMGVPWSDAPLVAQLMGTKLAVN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 536 EFVAYEHLSKFINLRKaagpkfvngvqqYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAG 615
Cdd:TIGR00804 320 EFVAYLDLSQYLQTRL------------WLSPKTEAIITFALCGFANFSSIGIILGGLGSLVPKRKSVISRLVLRALCAG 387
                         410
                  ....*....|....
gi 2000186022 616 TIACFMTACIAGML 629
Cdd:TIGR00804 388 TLVSLMSATIAGLY 401
NupC COG1972
Nucleoside permease NupC [Nucleotide transport and metabolism];
216-629 2.68e-153

Nucleoside permease NupC [Nucleotide transport and metabolism];


Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 450.31  E-value: 2.68e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 216 QQLISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFG-- 293
Cdd:COG1972     2 NILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGgl 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 294 ---EKYTDHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLP 370
Cdd:COG1972    82 agpGLPGGFVFAFQVLPPIIFFSALISILYYLGILQFIVRGIGWVLSKILGTSGAESLSAAANIFLGQTEAPLVIKPYLA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 371 HVTKSELHTIMTAGFATIAGSVLGAYISF-GVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENgDSRNL 449
Cdd:COG1972   162 KMTRSELFTVMTGGMATVAGSVLAAYASMlGVPAKYLLAASVMAAPAALLIAKILVPETEEPETDGVVEVEEEK-EPANF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 450 LEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDypQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIG 529
Cdd:COG1972   241 IDAIAEGALDGLKLALNVGAMLIAFVALIALVNGILGGLGGLFG--GLSLQRILGYLFAPLAWLIGVPWSEALQAGSLMG 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 530 YKTFFNEFVAYEHLSKFInlrkaagpkfvngvQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAM 609
Cdd:COG1972   319 TKLVLNEFVAYLDLAKLL--------------AGALSPRTVAIVTYALCGFANFSSIGIQIGGIGALAPERRSDIARLGL 384
                         410       420
                  ....*....|....*....|
gi 2000186022 610 RALIAGTIACFMTACIAGML 629
Cdd:COG1972   385 KALLAGTLASLLSATIAGLF 404
Nucleos_tra2_C pfam07662
Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport ...
405-627 1.26e-106

Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.


Pssm-ID: 462223  Cd Length: 205  Bit Score: 322.42  E-value: 1.26e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 405 HLLTASVMSAPAALAVAKLFWPETEKPKITLKnamkmENGDSRNLLEAATQGASSSIPLVANIAANLIAFLALLSFVNSA 484
Cdd:pfam07662   1 HLLTASVMSAPAALAISKLLYPETEEPPVKTG-----DEEEPANVLDAASNGALDGLKLALNIGAMLIAFVALVALINGL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 485 LSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFNEFVAYEHLSKFINlrkaagpkfvngvQQY 564
Cdd:pfam07662  76 LGWIGGLFGFPGLSLQLILGYVFAPLAWLMGVPWDDALQVGSLMGTKLVLNEFVAYLDLGKLIA-------------AGA 142
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2000186022 565 MSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAG 627
Cdd:pfam07662 143 LSPRSVAIATYALCGFANFSSIGIQIGGLGALAPERRGDIAKLGLRALLAGTLASLMSAAIAG 205
 
Name Accession Description Interval E-value
nupC TIGR00804
nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) ...
218-629 1.40e-158

nucleoside transporter; The Concentrative Nucleoside Transporter (CNT) Family (TC 2.A.41) Members of the CNT family mediate nucleoside uptake. In bacteria they are energized by H+ symport, but in mammals they are energized by Na+ symport. The different transporters exhibit differing specificities for nucleosides. The E. coli NupC permease transports all nucleosides (both ribo- and deoxyribonucleosides) except hypoxanthine and guanine nucleosides. The B. subtilis NupC is specific for pyrimidine nucleosides (cytidine and uridine and the corresponding deoxyribonucleosides). The mammalian permease members of the CNT family also exhibit differing specificities. Thus, rats possess at least two NupC homologues, one specific for both purine and pyrimidine nucleosides and one specific for purine nucleosides. At least three paralogues have been characterized from humans. One human homologue(CNT1) transports pyrimidine nucleosides and adenosine, but deoxyadenosine and guanosine are poor substrates of this permease. Another (CNT2) is selective for purine nucleosides. Alteration of just a few amino acyl residues in TMSs 7 and 8 interconverts their specificities. [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 273278 [Multi-domain]  Cd Length: 401  Bit Score: 463.70  E-value: 1.40e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 218 LISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYT 297
Cdd:TIGR00804   1 LISFVGLVVFILIAFLCSSNKKAISWRTVVSALVLQFLLGLIVLRTPPGFWAFQGLADQIQILLSYANEGSSFVFGPPLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 298 D--HFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKS 375
Cdd:TIGR00804  81 QdlFVFAFQVLPIIIFFSALISILYYLGIMQWVIRKIGWFLQKAMGTTKLESFSAAANIFLGQTEAPLVIRPYLGDMTDS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 376 ELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDsRNLLEAATQ 455
Cdd:TIGR00804 161 ELFTVMTSGMATIAGSVLGAYISMGVPATYLIAASVMAAPCALAFAKLIYPEVEESKEKSEEDVKLEEGD-QNFFEAASN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 456 GASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFN 535
Cdd:TIGR00804 240 GALAGVKVVANVAAMLIAFVALLALINGILSWVGGWVGYGGLSFQLIFGYVFRPLAFLMGVPWSDAPLVAQLMGTKLAVN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 536 EFVAYEHLSKFINLRKaagpkfvngvqqYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAG 615
Cdd:TIGR00804 320 EFVAYLDLSQYLQTRL------------WLSPKTEAIITFALCGFANFSSIGIILGGLGSLVPKRKSVISRLVLRALCAG 387
                         410
                  ....*....|....
gi 2000186022 616 TIACFMTACIAGML 629
Cdd:TIGR00804 388 TLVSLMSATIAGLY 401
NupC COG1972
Nucleoside permease NupC [Nucleotide transport and metabolism];
216-629 2.68e-153

Nucleoside permease NupC [Nucleotide transport and metabolism];


Pssm-ID: 441575 [Multi-domain]  Cd Length: 406  Bit Score: 450.31  E-value: 2.68e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 216 QQLISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFG-- 293
Cdd:COG1972     2 NILIGLLGIAVLLGIAWLFSENRKAINWRTVGIGLALQLLLAFLVLKVPAGRAAFEALSDGVNKLLSYANEGTAFVFGgl 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 294 ---EKYTDHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLP 370
Cdd:COG1972    82 agpGLPGGFVFAFQVLPPIIFFSALISILYYLGILQFIVRGIGWVLSKILGTSGAESLSAAANIFLGQTEAPLVIKPYLA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 371 HVTKSELHTIMTAGFATIAGSVLGAYISF-GVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENgDSRNL 449
Cdd:COG1972   162 KMTRSELFTVMTGGMATVAGSVLAAYASMlGVPAKYLLAASVMAAPAALLIAKILVPETEEPETDGVVEVEEEK-EPANF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 450 LEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDypQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIG 529
Cdd:COG1972   241 IDAIAEGALDGLKLALNVGAMLIAFVALIALVNGILGGLGGLFG--GLSLQRILGYLFAPLAWLIGVPWSEALQAGSLMG 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 530 YKTFFNEFVAYEHLSKFInlrkaagpkfvngvQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAM 609
Cdd:COG1972   319 TKLVLNEFVAYLDLAKLL--------------AGALSPRTVAIVTYALCGFANFSSIGIQIGGIGALAPERRSDIARLGL 384
                         410       420
                  ....*....|....*....|
gi 2000186022 610 RALIAGTIACFMTACIAGML 629
Cdd:COG1972   385 KALLAGTLASLLSATIAGLF 404
Nucleos_tra2_C pfam07662
Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport ...
405-627 1.26e-106

Na+ dependent nucleoside transporter C-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.


Pssm-ID: 462223  Cd Length: 205  Bit Score: 322.42  E-value: 1.26e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 405 HLLTASVMSAPAALAVAKLFWPETEKPKITLKnamkmENGDSRNLLEAATQGASSSIPLVANIAANLIAFLALLSFVNSA 484
Cdd:pfam07662   1 HLLTASVMSAPAALAISKLLYPETEEPPVKTG-----DEEEPANVLDAASNGALDGLKLALNIGAMLIAFVALVALINGL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 485 LSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFNEFVAYEHLSKFINlrkaagpkfvngvQQY 564
Cdd:pfam07662  76 LGWIGGLFGFPGLSLQLILGYVFAPLAWLMGVPWDDALQVGSLMGTKLVLNEFVAYLDLGKLIA-------------AGA 142
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2000186022 565 MSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAG 627
Cdd:pfam07662 143 LSPRSVAIATYALCGFANFSSIGIQIGGLGALAPERRGDIAKLGLRALLAGTLASLMSAAIAG 205
Gate pfam07670
Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for ...
302-400 4.25e-16

Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins. In the FeoB proteins, which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.


Pssm-ID: 429586 [Multi-domain]  Cd Length: 101  Bit Score: 74.21  E-value: 4.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2000186022 302 AFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVtMGSSPiESVVAAGNIFVGQTE----SPLLVQPYLPHVTKSEL 377
Cdd:pfam07670   1 LLKVLPIILFFSVLISILEYSGLLDRIGKLLGPLMRP-LGLFP-LPGKAAIALLLGFGAkevgVPLLATPYGIDTPRERL 78
                          90       100
                  ....*....|....*....|...
gi 2000186022 378 HTIMTAGFATIAGSVLGAYISFG 400
Cdd:pfam07670  79 AALLFTSFSTPCGATLPVYAGEL 101
Nucleos_tra2_N pfam01773
Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport ...
223-294 1.02e-14

Na+ dependent nucleoside transporter N-terminus; This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the N terminus of this family


Pssm-ID: 460319 [Multi-domain]  Cd Length: 73  Bit Score: 69.32  E-value: 1.02e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2000186022 223 GLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGE 294
Cdd:pfam01773   1 GLLVLLGIAWLFSKNRKAINWRTVIGGLALQFLLALFVLRTPAGRDAFKWISDGVTALLGYADAGTAFVFGG 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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