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Conserved domains on  [gi|18594498|ref|NP_570115|]
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GTPase IMAP family member 1 [Homo sapiens]

Protein Classification

GTPase IMAP family protein( domain architecture ID 10111261)

GTPase immunity-associated protein (IMAP) family protein may function as regulator of lymphocyte survival and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 28-229 4.16e-106

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 307.54  E-value: 4.16e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  28 RRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSkTDPGCEERGHCYLL 107
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS-PEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 108 SAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTeNRALRELVAECGGRVCA 187
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGRYVA 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 18594498 188 FDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQ 229
Cdd:cd01852 159 FNNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 28-229 4.16e-106

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 307.54  E-value: 4.16e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  28 RRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSkTDPGCEERGHCYLL 107
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS-PEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 108 SAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTeNRALRELVAECGGRVCA 187
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGRYVA 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 18594498 188 FDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQ 229
Cdd:cd01852 159 FNNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 28-229 1.86e-100

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 292.97  E-value: 1.86e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498    28 RRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSkTDPGCEERGHCYLL 107
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVS-NDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498   108 SAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAEcggrvca 187
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 18594498   188 fdnrATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQ 229
Cdd:pfam04548 153 ----ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIK 190
YeeP COG3596
Predicted GTPase [General function prediction only];
17-264 1.78e-09

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 57.85  E-value: 1.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  17 EENAQSRQESTRRLILVGRTGAGKSATGNSILGQrrffsRLGATSVTRACTTGSRR--W---DKCHVEVVDTPDIFSSQV 91
Cdd:COG3596  29 ALERLLVELPPPVIALVGKTGAGKSSLINALFGA-----EVAEVGVGRPCTREIQRyrLesdGLPGLVLLDTPGLGEVNE 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  92 SktdpgcEERGHCYLLSAPGPHALLLVTQ-LGRFTAQDQQAVRQVRDMFGEDVlkwMVIVFTRKEDLAGGSLHDYVSNTE 170
Cdd:COG3596 104 R------DREYRELRELLPEADLILWVVKaDDRALATDEEFLQALRAQYPDPP---VLVVLTQVDRLEPEREWDPPYNWP 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 171 NRALRELVaecggrvcafdnratgREQEAQVEQLLGMVEGLVLEHkGAHYSNEVY---ELAQVLRWAGPEERLRRVAERV 247
Cdd:COG3596 175 SPPKEQNI----------------RRALEAIAEQLGVPIDRVIPV-SAAEDRTGYgleELVDALAEALPEAKRSRLARLL 237

                       250
                ....*....|....*..
gi 18594498 248 AARVQRRPWGAWLSARL 264
Cdd:COG3596 238 RAKAIDRYTLLAAAAAL 254
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 30-89 1.21e-03

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 40.32  E-value: 1.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18594498    30 LILVGRTGAGKSATGNSILGQRRFFS---RLGATSVTRACTTgsrrWDKCHVEVVDTPDIFSS 89
Cdd:TIGR00993 121 ILVLGKSGVGKSATINSIFGEVKFSTdafGMGTTSVQEIEGL----VQGVKIRVIDTPGLKSS 179
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 28-229 4.16e-106

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 307.54  E-value: 4.16e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  28 RRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSkTDPGCEERGHCYLL 107
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVS-PEQLSKEIIRCLSL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 108 SAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTeNRALRELVAECGGRVCA 187
Cdd:cd01852  80 SAPGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDS-CEALKRLLEKCGGRYVA 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 18594498 188 FDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQ 229
Cdd:cd01852 159 FNNKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAE 200
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 28-229 1.86e-100

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 292.97  E-value: 1.86e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498    28 RRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSkTDPGCEERGHCYLL 107
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVS-NDFISKEIIRCLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498   108 SAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAEcggrvca 187
Cdd:pfam04548  80 AEPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCPEFLKEVLRT------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 18594498   188 fdnrATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQ 229
Cdd:pfam04548 153 ----ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIK 190
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 32-205 1.73e-10

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 58.62  E-value: 1.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  32 LVGRTGAGKSATGNSILGQrRFFSRLGATSVTRACTTGSRRWD--KCHVEVVDTPDIFSSQVSktdpgceERGHCYLLSA 109
Cdd:cd00882   2 VVGRGGVGKSSLLNALLGG-EVGEVSDVPGTTRDPDVYVKELDkgKVKLVLVDTPGLDEFGGL-------GREELARLLL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 110 PGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDvlKWMVIVFTrKEDLAGGSLHDYVsntenRALRELVAECGGRVCAFD 189
Cdd:cd00882  74 RGADLILLVVDSTDRESEEDAKLLILRRLRKEG--IPIILVGN-KIDLLEEREVEEL-----LRLEELAKILGVPVFEVS 145

                       170
                ....*....|....*.
gi 18594498 190 NRaTGREQEAQVEQLL 205
Cdd:cd00882 146 AK-TGEGVDELFEKLI 160
YeeP COG3596
Predicted GTPase [General function prediction only];
17-264 1.78e-09

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 57.85  E-value: 1.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  17 EENAQSRQESTRRLILVGRTGAGKSATGNSILGQrrffsRLGATSVTRACTTGSRR--W---DKCHVEVVDTPDIFSSQV 91
Cdd:COG3596  29 ALERLLVELPPPVIALVGKTGAGKSSLINALFGA-----EVAEVGVGRPCTREIQRyrLesdGLPGLVLLDTPGLGEVNE 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498  92 SktdpgcEERGHCYLLSAPGPHALLLVTQ-LGRFTAQDQQAVRQVRDMFGEDVlkwMVIVFTRKEDLAGGSLHDYVSNTE 170
Cdd:COG3596 104 R------DREYRELRELLPEADLILWVVKaDDRALATDEEFLQALRAQYPDPP---VLVVLTQVDRLEPEREWDPPYNWP 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 171 NRALRELVaecggrvcafdnratgREQEAQVEQLLGMVEGLVLEHkGAHYSNEVY---ELAQVLRWAGPEERLRRVAERV 247
Cdd:COG3596 175 SPPKEQNI----------------RRALEAIAEQLGVPIDRVIPV-SAAEDRTGYgleELVDALAEALPEAKRSRLARLL 237

                       250
                ....*....|....*..
gi 18594498 248 AARVQRRPWGAWLSARL 264
Cdd:COG3596 238 RAKAIDRYTLLAAAAAL 254
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 2-152 3.35e-09

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 56.17  E-value: 3.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498   2 GGRKMATDEENVYGLEENAQSRQE--STRRLILVGRTGAGKSATGNSILGQRRffsrlGATSVTRACTTG----SRRWDK 75
Cdd:cd01853   4 VGFQFFPDATQTKLHELEAKLKKEldFSLTILVLGKTGVGKSSTINSIFGERK-----VSVSAFQSETLRprevSRTVDG 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18594498  76 CHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPgPHALLLVTQLG--RFTAQDQQAVRQVRDMFGEDVLKWMVIVFT 152
Cdd:cd01853  79 FKLNIIDTPGLLESQDQRVNRKILSIIKRFLKKKT-IDVVLYVDRLDmyRVDNLDVPLLRAITDSFGPSIWRNAIVVLT 156
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 29-153 3.91e-04

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 39.14  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498    29 RLILVGRTGAGKSATGNSILGQRRFFS-RLGatsVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKtdpgcEERGHCYLL 107
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSdYPG---TTRDPNEGRLELKGKQIILVDTPGLIEGASEG-----EGLGRAFLA 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 18594498   108 SAPGPHALLLVTQLGRFTAQDQQAVRqvrdmFGEDVLKWMVIVFTR 153
Cdd:pfam01926  73 IIEADLILFVVDSEEGITPLDEELLE-----LLRENKKPIILVLNK 113
FlhF COG1419
Flagellar biosynthesis GTPase FlhF [Cell motility];
123-269 4.49e-04

Flagellar biosynthesis GTPase FlhF [Cell motility];


Pssm-ID: 441029 [Multi-domain]  Cd Length: 361  Bit Score: 41.39  E-value: 4.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 123 RFTAQD-QQAVRQVRDMFGEDVlkwmVIVFTRKEDlAGGSLHDY---------VSNTENRALRELVAECGGrvcafDNRA 192
Cdd:COG1419   5 KFVAKDmREALRKVKEELGPDA----VILSTRKVK-KGGFLKKVevtaavdedEAEKAPAAAAAPAAASAA-----AEEE 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498 193 TGREQEAQVEQLLGMVEGLV--LEHKGAHYSNEVYELAQVLRWAG-PEERLRRVAERVAARVQRRPWGAWLSARLWKWLK 269
Cdd:COG1419  75 ELEELRRELAELKELLEEQLsgLAGESARLPPELAELLERLLEAGvSPELARELLEKLPEDLSAEEAWRALLEALARRLP 154
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
 32-92 8.66e-04

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 38.86  E-value: 8.66e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18594498  32 LVGRTGAGKSATGNSILGqrrffSRLGATSVTRACTTGSRRWD----KCHVEVVDTPDIFSSQVS 92
Cdd:cd11383   2 LMGKTGAGKSSLCNALFG-----TEVAAVGDRRPTTRAAQAYVwqtgGDGLVLLDLPGVGERGRR 61
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 30-89 1.21e-03

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 40.32  E-value: 1.21e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18594498    30 LILVGRTGAGKSATGNSILGQRRFFS---RLGATSVTRACTTgsrrWDKCHVEVVDTPDIFSS 89
Cdd:TIGR00993 121 ILVLGKSGVGKSATINSIFGEVKFSTdafGMGTTSVQEIEGL----VQGVKIRVIDTPGLKSS 179
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 27-84 9.75e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 36.20  E-value: 9.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18594498    27 TRRLILVGRTGAGKSATGNSILGQRRFFSRLGATsVTRACTTGSRRWD--KCHVEVVDTP 84
Cdd:TIGR00231   1 DIKIVIVGHPNVGKSTLLNSLLGNKGSITEYYPG-TTRNYVTTVIEEDgkTYKFNLLDTA 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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