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Conserved domains on  [gi|55926078|ref|NP_571641|]
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peripherin-2a [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 120-262 6.21e-100

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


:

Pssm-ID: 239415  Cd Length: 143  Bit Score: 291.26  E-value: 6.21e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTDTPGRCYMKRTLDLMQMEFRCCGNNNYKDWFEIQWVSNRYLDFSAKEVKDRISSN 199
Cdd:cd03162   1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEIQWISNRYLDFSSKEVKDRIKSN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55926078 200 VDGKYLMDGVPFSCCNPSSPRPCIQQQITNNSAHYSYDHYTEDLNIWKRGCRDALVSYYGGMM 262
Cdd:cd03162  81 VDGRYLTDGVPFSCCNPSSPRPCIQHQITDNSAHYNYDYQTEELNLWTRGCREALLEYYTSKM 143
Tetraspanin pfam00335
Tetraspanin family;
16-167 4.05e-16

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 75.43  E-value: 4.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078    16 LAQMLWLMYWFSVMAGVLVFSMGLFFkIELRKRSELMDNNESHFVPNILIGVGLLACCLNAFGgkvCYDSLDSSKyakwk 95
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL-LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLG---CCGALKENR----- 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55926078    96 SIMTPFLICCLVFNFLLIVTAAMCFAMRIPLEFTLAEGLKNGMKYYKDTDTPGRCYMKRTLDLMQMEFRCCG 167
Cdd:pfam00335  72 CLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 120-262 6.21e-100

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 291.26  E-value: 6.21e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTDTPGRCYMKRTLDLMQMEFRCCGNNNYKDWFEIQWVSNRYLDFSAKEVKDRISSN 199
Cdd:cd03162   1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEIQWISNRYLDFSSKEVKDRIKSN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55926078 200 VDGKYLMDGVPFSCCNPSSPRPCIQQQITNNSAHYSYDHYTEDLNIWKRGCRDALVSYYGGMM 262
Cdd:cd03162  81 VDGRYLTDGVPFSCCNPSSPRPCIQHQITDNSAHYNYDYQTEELNLWTRGCREALLEYYTSKM 143
Tetraspanin pfam00335
Tetraspanin family;
16-167 4.05e-16

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 75.43  E-value: 4.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078    16 LAQMLWLMYWFSVMAGVLVFSMGLFFkIELRKRSELMDNNESHFVPNILIGVGLLACCLNAFGgkvCYDSLDSSKyakwk 95
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL-LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLG---CCGALKENR----- 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55926078    96 SIMTPFLICCLVFNFLLIVTAAMCFAMRIPLEFTLAEGLKNGMKYYKDTDTPGRCYMKRTLDLMQMEFRCCG 167
Cdd:pfam00335  72 CLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 120-262 6.21e-100

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 291.26  E-value: 6.21e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTDTPGRCYMKRTLDLMQMEFRCCGNNNYKDWFEIQWVSNRYLDFSAKEVKDRISSN 199
Cdd:cd03162   1 FIMRGSLEESLKTGLKNAMKFYKDTDTPGRCFLKKTIDMLQIEFQCCGNNGYRDWFEIQWISNRYLDFSSKEVKDRIKSN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55926078 200 VDGKYLMDGVPFSCCNPSSPRPCIQQQITNNSAHYSYDHYTEDLNIWKRGCRDALVSYYGGMM 262
Cdd:cd03162  81 VDGRYLTDGVPFSCCNPSSPRPCIQHQITDNSAHYNYDYQTEELNLWTRGCREALLEYYTSKM 143
Tetraspanin pfam00335
Tetraspanin family;
16-167 4.05e-16

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 75.43  E-value: 4.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078    16 LAQMLWLMYWFSVMAGVLVFSMGLFFkIELRKRSELMDNNESHFVPNILIGVGLLACCLNAFGgkvCYDSLDSSKyakwk 95
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWL-LSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLG---CCGALKENR----- 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55926078    96 SIMTPFLICCLVFNFLLIVTAAMCFAMRIPLEFTLAEGLKNGMKYYKDTDTPGRCYMKRTLDLMQMEFRCCG 167
Cdd:pfam00335  72 CLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG 143
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 120-258 1.23e-10

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 57.51  E-value: 1.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTDtpgrcYMKRTLDLMQMEFRCCGNNNYKDWfeiqwvsnryldfsakevkdrissn 199
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVDD-----DFQEAMDALQSTFECCGVNGPTDY------------------------- 50

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 55926078 200 vdgKYLMDGVPFSCCNPSSPRPCIqqqitnnsahysydhytedlNIWKRGCRDALVSYY 258
Cdd:cd03127  51 ---LDLRLLVPSSCCKGTDGNCGL--------------------NLYTEGCLEKLVDFL 86
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 126-256 4.46e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 53.51  E-value: 4.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 126 LEFTLAEGLKNGM-KYYKDTDTPGRcymKRTLDLMQMEFRCCGNNNYKDWFEIQWvsnryldfsakevkdrISSNVDGKY 204
Cdd:cd03155   7 LEDELKESLKRTMqENYGQSGEEAL---TLTVDELQQEFKCCGSNNYTDWQDSEW----------------INSNEANGR 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 55926078 205 LmdgVPFSCCNPSSPRPCIQQQITNNSahysydHYTEDlniwkrGCRDALVS 256
Cdd:cd03155  68 L---VPDSCCKTVVDRCGCLRDHPSNI------YKVEG------GCIPKLED 104
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 120-250 4.89e-08

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 50.06  E-value: 4.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTDTPGrcyMKRTLDLMQMEFRCCGNNNYKDWFEIqwvsnryldfsakevkdrissn 199
Cdd:cd03165   1 FVFREKVDLTAKDDLKEGLELYGTRNNRG---LTNAWDITQTEFRCCGVTNYTDWYEV---------------------- 55

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 55926078 200 vdgkYLMDGVPFSCCNpSSPRPCIQQQitnnsahysydhyteDLNIWKRGC 250
Cdd:cd03165  56 ----LGENRVPDSCCQ-EDSQDCGRNP---------------TELWWKTGC 86
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 130-255 4.18e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 48.07  E-value: 4.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 130 LAEGLKNGMK-YYKDTDTpgrcymKRTLDLMQMEFRCCGNNNYKDWfeiQWvsNRYLDFSakevkdriSSNVdgkyLMDG 208
Cdd:cd03158  11 LEENIRKAIVhYYDDLDL------QNIIDFVQKEFKCCGGDDYRDW---SK--NMYFNCS--------SPNP----EACG 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55926078 209 VPFSCCNPSSPrpciqQQITNNSAHY---SYDHYTEDLNIWKRGCRDALV 255
Cdd:cd03158  68 VPYSCCIRAKD-----QEVINTMCGYgvqNLERLEASKLIYTRGCIDAVV 112
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 133-214 1.36e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 46.31  E-value: 1.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 133 GLKNGMKYYKDTDtpgrcYMKRTLDLMQMEFRCCGNNNYKDWfeiqwvsnRYLDFSAKevkdrissnvdgkylmDGVPFS 212
Cdd:cd03166  14 SFNQMISNYNKTN-----DFRKILDRMQKDLKCCGANNYTDW--------ENIPSLDT----------------DSVPDS 64


                ..
gi 55926078 213 CC 214
Cdd:cd03166  65 CC 66
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 126-257 6.73e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 41.75  E-value: 6.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 126 LEFTLAEGLKNGMKYYKDTDTPGRcymkRTLDLMQMEFRCCGNNNYKDWFEIQWVSNRYLDFSAKevkdrissnvdgkyl 205
Cdd:cd03156   9 LEDSFKNLLKNNYGNYNSTGDAIT----STWNRVMIELKCCGVNGPTDFVDSTSFFRQKNEPNSP--------------- 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 55926078 206 mdgVPFSCCNPSSPRPCIQQQITNNSAHYSYDhytedlniwKRGCRDALVSY 257
Cdd:cd03156  70 ---YPESCCKRNSNSQIVDLDCPKLGSPNSYN---------KKGCYEKLSNP 109
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 126-217 7.72e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 41.26  E-value: 7.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 126 LEFTLAEGLKNGMKYYKDTDTPgrcymKRTLDLMQMEFRCCGNNNYKDWFEIQWVSNryldfsakevkdriSSNVDgkyl 205
Cdd:cd03163   8 VEDELNPSIDKVFNKYNGTNAE-----SRAVDYLQRQLQCCGIHNYTDWENTPWFKE--------------SKNNS---- 64

                        90
                ....*....|..
gi 55926078 206 mdgVPFSCCNPS 217
Cdd:cd03163  65 ---VPLSCCKET 73
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 120-214 7.83e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 38.98  E-value: 7.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTdtPGRCYMkrtLDLMQMEFRCCGNNNYKDwfeiqWVSNRYLDFSAKEVKdrissn 199
Cdd:cd03167   1 VALWGPLQDGLEHTLRLAIAHYQDD--PDLRFL---IDQVQLGLQCCGASSYQD-----WQQNLYFNCSSPGVQ------ 64

                        90
                ....*....|....*
gi 55926078 200 vdgkylMDGVPFSCC 214
Cdd:cd03167  65 ------ACSLPASCC 73
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 130-174 1.00e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 37.84  E-value: 1.00e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 55926078 130 LAEGLKNGM-KYYKDTDTpgrcymKRTLDLMQMEFRCCGNNNYKDW 174
Cdd:cd03164  11 VKEGLTDSLeQYHKDNNT------SEAWDMIQSNLQCCGINGTTDW 50
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 120-250 5.59e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 36.19  E-value: 5.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55926078 120 FAMRIPLEFTLAEGLKNGMKYYKDTDtpgrcYMKRTLDLMQMEFRCCGNNNYKDWFEIQWvsnryldfsakevkdrissn 199
Cdd:cd03161   1 FVFRHEIKGTFLRTYNEAVSNYNGDD-----ERSDAVDTVQRTLHCCGVENYTDWLNSPY-------------------- 55

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 55926078 200 vdgkYLMDGVPFSCCNpsSPRPCIQQQITNNSAHYSydhytedlNIWKRGC 250
Cdd:cd03161  56 ----FLEKGIPLSCCK--NRSDCSPQDLKNLTKAAT--------KVYQQGC 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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