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Conserved domains on  [gi|19115940|ref|NP_595028|]
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putative transporter [Schizosaccharomyces pombe]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 45-475 1.16e-131

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 385.78  E-value: 1.16e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 125 IALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSsIGWQWEFWIL 204
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 205 LILSGFNLFWAFLLLketyppvlnrkkfekygeigenepvalrltgkqllikllillsmkkpisillsqPILICVACTIG 284
Cdd:cd17323 160 AIISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVG 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 285 SIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAMPINQKFYSYLVKRNGGEGEPEFRLPMGFIGITL 364
Cdd:cd17323 186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 365 FEIGILLFGWTARYKIFWFVPTIGSAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGVKIFQLLLGAIFPLFAESLFRRL 444
Cdd:cd17323 266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 19115940 445 NYGWGCTLLAFILLACGCSLPILFKYGKQIR 475
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 45-475 1.16e-131

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 385.78  E-value: 1.16e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 125 IALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSsIGWQWEFWIL 204
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 205 LILSGFNLFWAFLLLketyppvlnrkkfekygeigenepvalrltgkqllikllillsmkkpisillsqPILICVACTIG 284
Cdd:cd17323 160 AIISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVG 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 285 SIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAMPINQKFYSYLVKRNGGEGEPEFRLPMGFIGITL 364
Cdd:cd17323 186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 365 FEIGILLFGWTARYKIFWFVPTIGSAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGVKIFQLLLGAIFPLFAESLFRRL 444
Cdd:cd17323 266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 19115940 445 NYGWGCTLLAFILLACGCSLPILFKYGKQIR 475
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-422 1.05e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.57  E-value: 1.05e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  37 PIRLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYS 116
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 117 VFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIG 196
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 197 WQWEFWILLILSGFNLFWAFLLLKETYPPVLNRKkfekygeigenepvalrltgkqllikllillsmKKPISILLSQPIL 276
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARL---------------------------------RGSLRELLRRPRL 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 277 ICVACTIGSIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAmpinqkfySYLVKRNGgegepefRLP 356
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA--------GRLADRFG-------RRR 274

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115940 357 MGFIGITLFEIGILLFGWTARYKIFWfvptIGSAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGV 422
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLL----LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
MFS_1 pfam07690
Major Facilitator Superfamily;
48-434 1.25e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 129.85  E-value: 1.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    48 ISSMTFLNQYGDSVFAPSISN-IAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIA 126
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   127 LSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWILLI 206
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   207 LSGFNLFWAFLLLKETYPPVLNRKKFEKYGEIgenepvalrltgkqllikllillsmkKPISILLSQPILICVActIGSI 286
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLI--------------------------VAWKALLRDPVLWLLL--ALLL 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   287 YGMINLVLIAFSEVWKSSYDFSPGISGLMYisitlGLFSAVFIAMPInqkFYSYLVKRNGgegePEFRLPMGFIGITLFE 366
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQEVLGLSALLAGLLL-----GLGGLLGAIGRL---LLGRLSDRLG----RRRRLLLALLLLILAA 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115940   367 IGILLFGWTARYKIFWFVptigSAIMGGGYIMTSNPLNMYVVDSYGI-YSASASAGVKIFQLLLGAIFP 434
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLA----LLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
85-222 1.06e-24

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 99.26  E-value: 1.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    85 TLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKD 164
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940   165 RGKYMVIYFTVLSIGPGIAPIISGFISQSSiGWQWEFWILLILSGFNLFWAFLLLKET 222
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFL-GWRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
64-232 6.08e-21

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 94.21  E-value: 6.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   64 PSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGL 143
Cdd:PRK11102  12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  144 FGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLFWAFLLLKETY 223
Cdd:PRK11102  92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETL 170


                 ....*....
gi 19115940  224 PPVlNRKKF 232
Cdd:PRK11102 171 PKE-RRQPF 178
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 45-475 1.16e-131

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 385.78  E-value: 1.16e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 125 IALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSsIGWQWEFWIL 204
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 205 LILSGFNLFWAFLLLketyppvlnrkkfekygeigenepvalrltgkqllikllillsmkkpisillsqPILICVACTIG 284
Cdd:cd17323 160 AIISGFCLILIFLFL------------------------------------------------------PIVLLLGLYVG 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 285 SIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAMPINQKFYSYLVKRNGGEGEPEFRLPMGFIGITL 364
Cdd:cd17323 186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 365 FEIGILLFGWTARYKIFWFVPTIGSAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGVKIFQLLLGAIFPLFAESLFRRL 444
Cdd:cd17323 266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 19115940 445 NYGWGCTLLAFILLACGCSLPILFKYGKQIR 475
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
37-422 1.05e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.57  E-value: 1.05e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  37 PIRLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYS 116
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 117 VFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIG 196
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 197 WQWEFWILLILSGFNLFWAFLLLKETYPPVLNRKkfekygeigenepvalrltgkqllikllillsmKKPISILLSQPIL 276
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARL---------------------------------RGSLRELLRRPRL 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 277 ICVACTIGSIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAmpinqkfySYLVKRNGgegepefRLP 356
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLA--------GRLADRFG-------RRR 274

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115940 357 MGFIGITLFEIGILLFGWTARYKIFWfvptIGSAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGV 422
Cdd:COG2814 275 LLLIGLLLLALGLLLLALAGSLWLLL----LALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 45-460 1.13e-33

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 130.77  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:cd17320   1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 125 IALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSiGWQWEFWIL 204
Cdd:cd17320  81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-GWRAIFVFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 205 LILSGFNLFWAFLLLKETYPPvlnrkkfekygeigENEPVALRLTGKQllikllillsmkkpISILLSQPILICVACTIG 284
Cdd:cd17320 160 ALLGLLLLLLVLLFLPETLPE--------------EKRKPLLSSLLRA--------------YKRVLKNRRFLGYALALG 211

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 285 SIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAmpinqkfySYLVKRNGgegePEFRLPMGFIGITL 364
Cdd:cd17320 212 LSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN--------GRLVRRFG----PRRLLRLGLLLLLA 279

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 365 FEIGILLFGWTARYKIFWFVPTIgsAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGVKIFQLLLGAIFPLFAESLFR-- 442
Cdd:cd17320 280 AALVLLLAALLGGLSLWPLVAPL--FLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNgt 357

                       410
                ....*....|....*...
gi 19115940 443 RLNYGWGCTLLAFILLAC 460
Cdd:cd17320 358 ALPMGLLILVLGLLALLL 375
MFS_1 pfam07690
Major Facilitator Superfamily;
48-434 1.25e-33

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 129.85  E-value: 1.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    48 ISSMTFLNQYGDSVFAPSISN-IAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIA 126
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   127 LSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWILLI 206
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   207 LSGFNLFWAFLLLKETYPPVLNRKKFEKYGEIgenepvalrltgkqllikllillsmkKPISILLSQPILICVActIGSI 286
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLI--------------------------VAWKALLRDPVLWLLL--ALLL 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   287 YGMINLVLIAFSEVWKSSYDFSPGISGLMYisitlGLFSAVFIAMPInqkFYSYLVKRNGgegePEFRLPMGFIGITLFE 366
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQEVLGLSALLAGLLL-----GLGGLLGAIGRL---LLGRLSDRLG----RRRRLLLALLLLILAA 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115940   367 IGILLFGWTARYKIFWFVptigSAIMGGGYIMTSNPLNMYVVDSYGI-YSASASAGVKIFQLLLGAIFP 434
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLA----LLLLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 48-460 1.04e-26

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 111.13  E-value: 1.04e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  48 ISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIAL 127
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 128 SVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLIL 207
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD-ALGYRAPFLVCAAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 208 SGFNLFWAFLLLKETYPPVLNRKKfekygeigenepvalrltgkqllikllILLSMKKPISILLSQPILICVACTIGSIY 287
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAV---------------------------SAARLRSGLRLLLRDRRLLALFLAIFVLA 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 288 GMINLVLIAFSEVWKSSYDFSPGISGLmyisitlgLFSAVFIAMPINQKFYSYLVKRNGgegepefRLPMGFIGITLFEI 367
Cdd:cd17325 213 FAFGALEPFLPLYAAELGGLSPAQIGL--------LFGAQGLASALSQPPAGKLSDRIG-------RKPLILIGLLLSAV 277

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 368 GILLFGWTARykiFWFVpTIGSAIMGGGYIMTSNPLNMYVVD---------SYGIYSASASAGVkifqlllgAIFPLFAE 438
Cdd:cd17325 278 ALLLLPLATS---FWLL-LLLLALLGLGLGLVFPATLALLADivppegrgtAMGLFNTAFSLGM--------VLGPLLGG 345

                       410       420
                ....*....|....*....|..
gi 19115940 439 SLFRRLNYGWGCTLLAFILLAC 460
Cdd:cd17325 346 FLYDAFGFATPFLAAAALLLLA 367
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 37-218 9.24e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 106.82  E-value: 9.24e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  37 PIRLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYS 116
Cdd:COG0477   8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 117 VFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIG 196
Cdd:COG0477  88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA-ALG 166

                       170       180
                ....*....|....*....|..
gi 19115940 197 WQWEFWILLILSGFNLFWAFLL 218
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRL 188
2_A_01_02 TIGR00880
Multidrug resistance protein;
85-222 1.06e-24

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 99.26  E-value: 1.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    85 TLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKD 164
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940   165 RGKYMVIYFTVLSIGPGIAPIISGFISQSSiGWQWEFWILLILSGFNLFWAFLLLKET 222
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFL-GWRAPFLFLAILALAAFILLAFLLPET 141
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 45-393 5.06e-23

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 100.34  E-value: 5.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:cd17474   1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 125 IALSVNLAMFLVFRFFSGLfGSVGLSNGSGSLA-DLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqsSIGWQWEFWI 203
Cdd:cd17474  81 CGLSDSFALLLAGRALQGI-GAAGLGPLALTLIgDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA--AISWRYPFFL 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 204 LLILSGFNLFWAFLLLKETYPPVLNRKKFEKygeigenepvalrltgkqllikllillsmKKPISILLSQPILICV--AC 281
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSSATKL-----------------------------RDLKKALRGRGLLTFLvsAF 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 282 TIGSIYGminLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAMPINQKFYSylvkrnggegepeFRLPMgFIG 361
Cdd:cd17474 209 LYFFLYF---AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFG-------------ARRIL-VIG 271

                       330       340       350
                ....*....|....*....|....*....|..
gi 19115940 362 ITLFEIGILLFGWTARYKIFWFVPTIGSAIMG 393
Cdd:cd17474 272 LLLYALSLLLLGFVPSLALLLIAIVLFGLGLG 303
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 45-459 2.65e-22

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 98.61  E-value: 2.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:TIGR00710   7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   125 IALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWIL 204
Cdd:TIGR00710  87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILV-WLSWHAIFAFL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   205 LILSGFNLFWAFLLLKETYPPvlnrKKFEKYGEIGENepvalrltgkqllikllillsmkkpISILLSQPILICVACTIG 284
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPY----EARIQISTYFET-------------------------FLLLLKSKMFWGYALIYG 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   285 SIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFiampinqkFYSYLVKRNGGEGepefrlpMGFIGITL 364
Cdd:TIGR00710 217 ASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGF--------LNGRFIKKWGAKS-------LLRMGLIL 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   365 FEIGILLFGWTARYKIFWFVPTIGSA-IMGGGYIMTSNPLNMYVVDSYGIYSASASAGVKIFQLLLGAIFPLFAESLFRR 443
Cdd:TIGR00710 282 FAVSAVLLEITAILGLGSWAMIIGPMmFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGN 361

                         410
                  ....*....|....*...
gi 19115940   444 --LNYGWGCTLLAFILLA 459
Cdd:TIGR00710 362 taWPMSLSCLVLAVVSVL 379
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 48-433 5.33e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 94.42  E-value: 5.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  48 ISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIAL 127
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 128 SVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFI-SQSSIGWQWEFWILLI 206
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILaSSLGFGWRAVFLIAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 207 LSGFNLFWAFLLLKETYPPVLNRKKFEKYGEIgenepvalrltgkqllikllillsmKKPISILLSQPILICVACTIGSI 286
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSV-------------------------LKLLKRVLKNPGLWLLLLAIFLV 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 287 YGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLGLFSAVFIAMPINQKFYSylvkrnggegepefRLPMGFIGITLFE 366
Cdd:cd06174 216 NLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------------RKPLLLIGLLLMA 281

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940 367 IGILLFGWTARYKIFWFVPTIGSAIMGGGYIMTSNPLNMYVVDSY-GIYSASASAGVKIFQLLLGAIF 433
Cdd:cd06174 282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIrGTAFGLLNTFGFLGGAIGPLLA 349
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
64-232 6.08e-21

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 94.21  E-value: 6.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   64 PSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGL 143
Cdd:PRK11102  12 PALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  144 FGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLFWAFLLLKETY 223
Cdd:PRK11102  92 AAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETL 170


                 ....*....
gi 19115940  224 PPVlNRKKF 232
Cdd:PRK11102 171 PKE-RRQPF 178
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
37-469 7.66e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 93.78  E-value: 7.66e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  37 PIRLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYS 116
Cdd:COG2271   4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 117 VFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIG 196
Cdd:COG2271  84 LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA-AFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 197 WQWEFWILLILSGFNLFWAFLLLketyppvlnrkkfekygeigenepvalrltgkqllikllillsmkkpisillsqpiL 276
Cdd:COG2271 163 WRAAFLILGLPGLLLALLRFWLL--------------------------------------------------------A 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 277 ICVACTIGSIYGMINLVLIAFSEVwkssYDFSPGISGLMYISITLglfsAVFIAMPINQKFYSYLVKRnggegepefRLP 356
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEV----RGLSLAQAGLLLSLPFL----AGIVGSLLGGWLSDRLGRR---------RKL 249

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 357 MGFIGITLFEIGILLFGWTARYKIFWfvptIGSAIMGGGYIMTSNPLNMYVVDSYGI-YSASASAGVKIFQLLLGAIFPL 435
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAI----ALLFLAGFGLGGAFGLLWALAAELFPKkARGTASGLVNTFGFLGGALGPL 325

                       410       420       430
                ....*....|....*....|....*....|....
gi 19115940 436 FAESLFRRLNYGWGCTLLAFILLACGCSLPILFK 469
Cdd:COG2271 326 LVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 69-460 6.09e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 91.07  E-value: 6.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  69 IAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVG 148
Cdd:cd17324  25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 149 LSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLFWAFLLLketyPPVLN 228
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLALLAALLLWRLL----PSLPP 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 229 RKKfekygeigenepvalrltgkqllikllILLSMKKPISILLSQPILIcvactigSIYGMINLVLIAFSEVWKSSYDFS 308
Cdd:cd17324 180 KKP---------------------------GSLGLLSSLLLLLRNPRLR-------LAYLITFLLFGGFFALYTYLAPFL 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 309 PGISGLMYISITlGLFSAVFIAMPINQKFYSYLVKRNGGegepeFRLPMGFIGITLfeIGILLFGWTARykifWFVPTIG 388
Cdd:cd17324 226 TDVPGFSSSAII-GLLLLFGVAGVVGSPLAGRLADRGGR-----RALLIALLLLAA--ALLLLTLLGPS----PLLLLVG 293

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115940 389 SAIMGGGYIMTSNPLNMYVVDSYGIYSASASAGVKIFQLLLGAIFPLFAESLFRRLNY---GWGCTLLAFILLAC 460
Cdd:cd17324 294 LVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWagvGWVGAALLLLALLL 368
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 60-215 6.40e-20

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 91.08  E-value: 6.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:cd17321  13 TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARA 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115940 140 FSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLFWA 215
Cdd:cd17321  93 LQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-LFGWRWIFLINVPIGLVALLLA 167
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
43-231 1.36e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 75.30  E-value: 1.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  43 RNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQ 122
Cdd:COG2223   5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 123 IPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFW 202
Cdd:COG2223  85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA-AFGWRNAFL 163

                       170       180
                ....*....|....*....|....*....
gi 19115940 203 ILLILSGFNLFWAFLLLKETYPPVLNRKK 231
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 60-213 1.32e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 71.83  E-value: 1.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIAEQFHASrTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:cd17502  13 TIVATALPTIVAEFGGL-SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRA 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115940 140 FSGLfGSVGLSNGSGSL-ADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLF 213
Cdd:cd17502  92 IQGI-GGGGLMSLAFIIiADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD-HLSWRWCFYINLPIGGLALA 164
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 60-207 3.40e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 71.07  E-value: 3.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIAEQFHASRTLVTLGATLYTLGilfgNLIFAPLS----EQFGRRPIYLIGYSVFALLQIPIALSVNLAMFL 135
Cdd:cd17503  13 TIVNVALPTIMGDLGASLDTVQWVITSYLLA----LAIMIPLSgwlaDRFGTRRLFLTALALFTLGSLLCGLAPNLASLI 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115940 136 VFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWILLIL 207
Cdd:cd17503  89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT-DNLSWRWIFYINLPI 159
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 46-399 3.47e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 70.68  E-value: 3.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  46 IVISSMTFLNQYGDSVFAPSISNIAEQFH-ASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIP 124
Cdd:cd17473   2 ITLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 125 IALSVNLAMFLVFRFFSGLfGSVGLSNGSGSL-ADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFIsqSSIGWQWEFWI 203
Cdd:cd17473  82 GLFLDSLYALLASRALLGI-GVAGIMTLATALiGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRAPFLV 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 204 LLiLSGFNLFWAFLLLKETYPPvlnrkkfekygEIGENEPVALRLTGKqllikllillsMKKPIsillsqpILICVACTI 283
Cdd:cd17473 159 YL-LALPVLILVLLFLPEPARK-----------SKSAASPGAATAAAL-----------PWKRV-------LPIYFLAFL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 284 GSIygMINLVLIAFSEVWKSSYDFSPGISGLmyisitlgLFSAVFIAMPINQKFYSYLVKRNGgegePEFRLPMGFIgit 363
Cdd:cd17473 209 AML--LFYVIPIQLPFLLQERGGGSAALIGL--------ALAIASLAGAIGALLFGRLKRRLG----KRRLLAIGFA--- 271

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 19115940 364 LFEIGILLFGWTARYKifWFVPTIGSAIMGGGYIMT 399
Cdd:cd17473 272 LMALGFLLLALASGLW--VVLLGAILAGLGFGLLLP 305
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-219 8.66e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.53  E-value: 8.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  39 RLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQ-FHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSV 117
Cdd:cd17325 195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 118 FALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGW 197
Cdd:cd17325 275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGF 353

                       170       180
                ....*....|....*....|..
gi 19115940 198 QWEFWILLILSGFNLFWAFLLL 219
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 48-219 3.89e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 64.54  E-value: 3.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  48 ISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIAL 127
Cdd:cd17489   1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 128 SVNLAMFLVFRFFSGL-FGSVGLSNGSGSlADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQssigwQWEFWILLI 206
Cdd:cd17489  81 ATSVALLLVLRLIHGIgWGAFTTAAATLV-ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-----HLGFAVLFI 154

                       170
                ....*....|...
gi 19115940 207 LSGFNLFWAFLLL 219
Cdd:cd17489 155 VAAVLALLALLLV 167
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 45-231 9.14e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 63.40  E-value: 9.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSIS-NIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQI 123
Cdd:cd17329   1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 124 PIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIgwQWEFWI 203
Cdd:cd17329  81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLA 158

                       170       180
                ....*....|....*....|....*...
gi 19115940 204 LLILSGFNLFWAFLLLKETYPPVLNRKK 231
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETRPKRRAAEK 186
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 68-220 9.52e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 63.36  E-value: 9.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  68 NIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSV 147
Cdd:cd17319  28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAG 107

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115940 148 GLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFIsQSSIGWQWEFWILLILSGFNLFWAFLLLK 220
Cdd:cd17319 108 FFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-223 1.79e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.58  E-value: 1.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSIsnIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRR--PIYLIGYSVFALLQ 122
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALAL 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 123 IPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSiGWQWEFW 202
Cdd:COG2271 263 LLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFL 341

                       170       180
                ....*....|....*....|.
gi 19115940 203 ILLILSGFNLFWAFLLLKETY 223
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 60-214 2.33e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 61.85  E-value: 2.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIaEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:cd17316  19 GFVAPVLAAE-FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRF 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940 140 FSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFIS---QSSIGWQWEFWILLILSGFNLFW 214
Cdd:cd17316  98 LQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllSGDWGWRILFLIGALPALLALLL 175
emrD PRK11652
multidrug transporter EmrD;
56-224 2.51e-10

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 62.23  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   56 QYGDSVFAPSISNIAEQFHASRTLV--TLGATLYTLGILfgNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAM 133
Cdd:PRK11652  21 QMAQTIYVPAIADMARDLNVREGAVqaVMAAYLLTYGLS--QLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  134 FLVFRFFSGLFGSVGlsngsGSLA-----DLFEkkdrGKYMVIYFTVLSIG----PGIAPIISGFISqSSIGWQWEFWIL 204
Cdd:PRK11652  99 LIAASAIQGLGTGVG-----GVMArtlprDLYE----GTQLRHANSLLNMGilvsPLLAPLIGGLLT-TLFGWRACYLFL 168

                        170       180
                 ....*....|....*....|
gi 19115940  205 LILSGFNLFWAFLLLKETYP 224
Cdd:PRK11652 169 LLLGAGVTFSMARWMPETRP 188
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
64-224 4.53e-10

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 61.49  E-value: 4.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   64 PSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGL 143
Cdd:PRK15402  34 PGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  144 ----FGSVGLSngsgSLADLFEKKDRGKYMVIYFTVLSIGPGIAPII-SGFISQSSigWQWEFWILLILSGFnlfwAFLL 218
Cdd:PRK15402 114 glcfIGAVGYA----AIQESFEEADAIKITALMANVALLAPLLGPLVgAALIHVLP--WRGMFVLFAALAAL----SFFG 183


                 ....*.
gi 19115940  219 LKETYP 224
Cdd:PRK15402 184 LWRAMP 189
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 75-218 6.14e-10

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 61.19  E-value: 6.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    75 ASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSG 154
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115940   155 SLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQssigWQWefwiLLILSGFNLFWAFLL 218
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD----WRW----LQLAVSLPTFLFFLL 259
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 79-219 6.80e-10

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 60.29  E-value: 6.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  79 LVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLAD 158
Cdd:cd17317  26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19115940 159 LFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQssigWQwefWILLILSGFNLFWAFLLL 219
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD----WR---WLQLAISLPGLLFLLLLW 159
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 46-240 7.91e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 61.10  E-value: 7.91e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  46 IVISSMTFLNQYGDSVFAPSISNIAEQFHASrTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPI 125
Cdd:cd06179   1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 126 ALSVNLAMFLVFRFFSGlFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISG-FISQSSIGWQWEFWIL 204
Cdd:cd06179  80 GTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGaLVEANAAGWRWIFYIN 158

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 19115940 205 LILSGFnlfwAFLLLKETY--PPVLNRKKFEKYGEIGE 240
Cdd:cd06179 159 AIFNAL----ALILLFFFYhpPPRPQLHGSSTRQKLKR 192
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 50-222 8.07e-10

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 60.41  E-value: 8.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  50 SMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSV 129
Cdd:cd17333   3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 130 NLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKdRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGWQWEFWILLILS- 208
Cdd:cd17333  83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYl 161

                       170
                ....*....|....
gi 19115940 209 GFNLFWAFLLLKET 222
Cdd:cd17333 162 LLAILILLTLFPEL 175
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
64-222 8.44e-10

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 60.61  E-value: 8.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   64 PSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGL 143
Cdd:PRK15403  37 PGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGT 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115940  144 FGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPiISGFISQSSIGWQWEFWILLILSGFNLFWAFLLLKET 222
Cdd:PRK15403 117 SICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGP-LSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 96-234 1.56e-09

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 59.57  E-value: 1.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  96 LIFAP----LSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGlSNGSGSLADLFEKKDRGKYMVI 171
Cdd:cd17388  52 FIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATG-AVAAAYIADVTPPEQRARNFGL 130

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115940 172 YFTVLSIGPGIAPIISGFISQssIGWQWEFWILLILSGFNLFWAFLLLKETYPPVLNRKKFEK 234
Cdd:cd17388 131 LGAAFGLGFIAGPALGGLLGE--ISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWR 191
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
39-217 1.75e-09

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 59.48  E-value: 1.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  39 RLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVF 118
Cdd:COG0738   4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 119 ALLQIPIALSVNLAMFLVFRFFSGLFGSVgLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIG-- 196
Cdd:COG0738  84 ALGLLLFALAPSYPLLLLALFLLGLGLGL-LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSls 162

                       170       180
                ....*....|....*....|.
gi 19115940 197 WQWEFWILLILSGFNLFWAFL 217
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLR 183
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 53-231 2.53e-09

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 58.90  E-value: 2.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  53 FLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLA 132
Cdd:cd17396  10 FVHGMGVIILAQNMSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLI 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 133 MFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVlSIGPGIAPIISGFISQSSIGWQWEFWILLILSGFNl 212
Cdd:cd17396  90 IAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFV-SFGQFLLPFIIAFLAANNLWYGWSFIVPAAVLVLN- 167

                       170
                ....*....|....*....
gi 19115940 213 fwAFLLLKETYPPVLNRKK 231
Cdd:cd17396 168 --ALLLLKLSFPPQTVTAA 184
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 69-207 3.03e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 58.37  E-value: 3.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  69 IAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVG 148
Cdd:cd17365  25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115940 149 LSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLIL 207
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIP-AFGWRSVFLLGGVP 162
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 89-203 4.77e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 58.14  E-value: 4.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    89 LGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKY 168
Cdd:TIGR00895  63 IGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTA 142

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 19115940   169 MVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWI 203
Cdd:TIGR00895 143 VGLMFCGYPIGAAVGGFLAGWLI-PVFGWRSLFYV 176
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
64-208 5.92e-09

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 57.98  E-value: 5.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   64 PSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSgl 143
Cdd:PRK11043  27 PAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQ-- 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115940  144 fgSVGL-SNGSGSLADLFEKKDRGKYMVIYFTVL---SIGPGIAPIISGFISQSSiGWQWEFWILLILS 208
Cdd:PRK11043 105 --AVGVcSAAVIWQALVIDRYPAQKANRVFATIMplvALSPALAPLLGAWLLNHF-GWQAIFATLFAIT 170
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 46-227 7.78e-09

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 57.27  E-value: 7.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  46 IVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPI 125
Cdd:cd17476   1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 126 ALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKkdrGKYMVIYFTVLS----IGPGIAPIISGFISQsSIGWQWEF 201
Cdd:cd17476  81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPP---GPRKNIVFSLFGatapLGFALGGVFGGLFAQ-LAWWPWIF 156

                       170       180
                ....*....|....*....|....*.
gi 19115940 202 WILLILSGFNLFWAFLLLKETYPPVL 227
Cdd:cd17476 157 WFLAILAAIVAVAAIFWTSPSFIAVL 182
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
40-220 8.19e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 57.58  E-value: 8.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  40 LKVRNVIVISSMTFLNQYGDSVFAPSISNIA-EQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVF 118
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 119 ALLQIPIALSV-NLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGW 197
Cdd:COG2223 282 ALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSY 361

                       170       180
                ....*....|....*....|...
gi 19115940 198 QWEFWILLILSGFNLFWAFLLLK 220
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYR 384
Sugar_tr pfam00083
Sugar (and other) transporter;
47-440 8.25e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 57.67  E-value: 8.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    47 VISSMTFLNQYgDSVFAPSISNiaEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIG---YSVFALLQI 123
Cdd:pfam00083  18 VIGAFLTLIDF-FKNFGLSKSV--SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   124 PIALSVNLAMFLVFRFFSGLFgsVGLSNG--SGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSS--IGWQW 199
Cdd:pfam00083  95 AAKGKWSVYQLIVGRVLVGIG--VGGASVlaPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSnsDGWRI 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   200 EFWILLILSGFNLFWAFLLLKETYPPVLNRKKFEKYGEIGENEPVALRLTGKQLLIKLLILLSMKKPISILL-------S 272
Cdd:pfam00083 173 PLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKElfstktrR 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   273 QPILICVACTIGSIYGMINLVLIAFSEVWKSSydfspGISGLMYISITLGLFSAVFIAMPInqkfysYLVKRNGgegepe 352
Cdd:pfam00083 253 QRLLIGVMLQIFQQLTGINAIFYYSTTIFENL-----GLSDSFLVTIIVGVVNFVFTFIAI------FLVDRFG------ 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   353 fRLPMGFIGIT-----LFEIGILLFGWTARYKIFWFVPTIGSAIMGGGYIMTSNPLnMYVVDS-------YGIYSASASA 420
Cdd:pfam00083 316 -RRPLLLLGAAgmaicFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPV-PWVIVSelfplsvRSKAMALATA 393

                         410       420
                  ....*....|....*....|
gi 19115940   421 GVKIFQLLLGAIFPLFAESL 440
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAI 413
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 42-218 8.30e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 57.24  E-value: 8.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  42 VRNVIVISSMTFLNQYGDSVFAPSIsnIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALL 121
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLL--AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 122 QIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEF 201
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD-ALGLSAVF 366

                       170
                ....*....|....*..
gi 19115940 202 WILLILSGFNLFWAFLL 218
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 51-221 9.39e-09

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 56.85  E-value: 9.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  51 MTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVN 130
Cdd:cd17390   4 VGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 131 LAMFLVFRFFSGLFGSVgLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGWQWEFWILLILSGF 210
Cdd:cd17390  84 LALLFLSRIPLGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFIL 162

                       170
                ....*....|.
gi 19115940 211 NLFWAFLLLKE 221
Cdd:cd17390 163 NAGLVWFLLSK 173
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 62-227 1.01e-08

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 56.90  E-value: 1.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  62 FAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFS 141
Cdd:cd17312  22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 142 GLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLFWAFLLLKE 221
Cdd:cd17312 102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPGIVGLVVAIILFFFLRD 180


                ....*.
gi 19115940 222 TyPPVL 227
Cdd:cd17312 181 S-PPYV 185
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 60-221 2.19e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 56.03  E-value: 2.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:cd17477  13 GLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRF 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 140 FSGlFGSVGLSNGSGS-LADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSsiGWQWeFWILLILSGFNLFWAFLL 218
Cdd:cd17477  93 VMG-IGLAGLFVVSESwLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA--GALP-FLIAAVLLLLALVPLLLT 168


                ...
gi 19115940 219 LKE 221
Cdd:cd17477 169 RRA 171
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
68-224 3.76e-08

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 55.41  E-value: 3.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   68 NIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLfgsv 147
Cdd:PRK10473  28 RIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI---- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  148 glsnGSGS--------LADLFEKKDRGKYMVIYFTVLSIGPGIAPIIsGFISQSSIGWQWEFWILLILSGFNLFWAFLLL 219
Cdd:PRK10473 104 ----GAGCcyvvafaiLRDTLDDRRRAKVLSLLNGITCIIPVLAPVL-GHLIMLKFPWQSLFYTMAAMGILVLLLSLFIL 178


                 ....*
gi 19115940  220 KETYP 224
Cdd:PRK10473 179 KETRP 183
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 35-207 3.99e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.92  E-value: 3.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  35 TWPIRLKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFhaSRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIG 114
Cdd:cd17316 172 ALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGL--SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 115 YSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGS--LADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQ 192
Cdd:cd17316 250 LILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYayLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA 329

                       170
                ....*....|....*
gi 19115940 193 SSIGWQWEFWILLIL 207
Cdd:cd17316 330 STGGTGVPALILALL 344
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 61-156 5.46e-08

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 54.78  E-value: 5.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  61 VFAPSISNIAEQFHASRTL---VTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVF 137
Cdd:cd17377  19 HFSSSFTSIVSEWFLVGNAaykVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVS 98

                        90
                ....*....|....*....
gi 19115940 138 RFFsglfgsVGLSNGSGSL 156
Cdd:cd17377  99 RFL------VGVMNGGMSL 111
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 48-235 8.23e-08

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 54.14  E-value: 8.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  48 ISSMTFLNQYGDSVFAPSISNIAEQ-FHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIA 126
Cdd:cd17472   1 LSLIFSLRMLGMFLVLPVLSVYAKSlPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 127 LSVNLAMFLVFRFF--SGLFGSVGLSngsgSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWIL 204
Cdd:cd17472  81 YATSIYGLILGRALqgSGAISSVVMA----LLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAA-HLGVSGLFLIT 155

                       170       180       190
                ....*....|....*....|....*....|.
gi 19115940 205 LILSGFNLFWAFLLLKETYPPVLNRKKFEKY 235
Cdd:cd17472 156 AILSLVSLLILLFFVPDPPKIVQISEKEKKK 186
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 62-220 1.51e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 53.53  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    62 FAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFS 141
Cdd:TIGR00881  14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   142 GLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGWQWefwiLLILSGF-NLFWAFLLLK 220
Cdd:TIGR00881  94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHW----VFIVPGIiAIIVSLICFL 169
PRK03699 PRK03699
putative transporter; Provisional
 60-207 2.24e-07

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 53.01  E-value: 2.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940   60 SVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:PRK03699  24 IVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLMFSHSLALFSIAMF 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940  140 FSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGWQWEFWILLIL 207
Cdd:PRK03699 104 VLGVVSGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIEWYWVYACIGLV 171
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 57-143 3.25e-07

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 52.03  E-value: 3.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  57 YGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLV 136
Cdd:cd17446  12 YDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCV 91


                ....*..
gi 19115940 137 FRFFSGL 143
Cdd:cd17446  92 FRFLTGM 98
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 57-150 3.59e-07

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 52.04  E-value: 3.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  57 YGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLV 136
Cdd:cd17447  14 YDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAI 93

                        90
                ....*....|....
gi 19115940 137 FRFFSGlFGSVGLS 150
Cdd:cd17447  94 TRTLTG-FALTGFS 106
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 85-232 5.55e-07

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 51.51  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  85 TLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLF-GSVGLSngSGSLADLFEKK 163
Cdd:cd17389  71 SLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISkGNVSLS--TAIVADVTSPK 148

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115940 164 DRGKYMV---IYFTV-LSIGPGIAPIISGFISQSSIGW-QWEFWILLILSGFNLFWAFLLLKETYPPVLNRKKF 232
Cdd:cd17389 149 KRSKGMAligVAFSLgFIIGPMIGAYFASFTRSLGEVFfSMPALFALVLALADLLFIFFFLPETLPSNLRRLGL 222
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 49-208 7.65e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 51.04  E-value: 7.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  49 SSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALS 128
Cdd:cd17504   2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 129 VNLAMFLVFRFFSGLFGSVgLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILS 208
Cdd:cd17504  82 PNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ-HLGWRWIFWTAAPVA 159
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 63-217 1.08e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 50.70  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  63 APSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSG 142
Cdd:cd17475  16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940 143 LFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWI---LLILSGFnLFWAFL 217
Cdd:cd17475  96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA-LHYGWRAAFVVaglVSILAAV-LFWLFY 171
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 89-199 1.08e-06

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 50.43  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  89 LGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKY 168
Cdd:cd17379  44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123

                        90       100       110
                ....*....|....*....|....*....|.
gi 19115940 169 MVIYFTVLSIGPGIAPIISGFISQssigWQW 199
Cdd:cd17379 124 GIVYQMFFTLGLLILPGIAYFIPH----WRW 150
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 88-207 1.10e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 50.65  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  88 TLGILFGNLIFAPLSEQ-FGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFgsVGLSNGSGS--LADLFEKKD 164
Cdd:cd17474 244 SVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG--LGLNLPLLTtlVTELAPEEE 321

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 19115940 165 RGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWILLIL 207
Cdd:cd17474 322 RGTASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSAPFLVGAAI 363
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 59-221 1.30e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 50.70  E-value: 1.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  59 DSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFR 138
Cdd:cd17328  15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 139 FFSGlFGSVGLSNGSGSL-ADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGWQWEFWILLILSGFNLFWAFL 217
Cdd:cd17328  95 ALVG-IGEASYSPIAPTIiADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLL 173


                ....
gi 19115940 218 LLKE 221
Cdd:cd17328 174 FVRE 177
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
40-190 1.35e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 1.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  40 LKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQ-FHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVF 118
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 119 ALLQIPIALSV--NLAMFLVFRFFSGLFGSVGLSNGSGSLADLFE-------KKDRGKYMVIYFTVLSIGPGIAPIISGF 189
Cdd:COG2211 305 ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGL 384


                .
gi 19115940 190 I 190
Cdd:COG2211 385 L 385
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 76-157 1.65e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  76 SRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGlFGSVGLSNGSGS 155
Cdd:cd17374  33 SQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAG-FAVSGISINTLI 111


                ..
gi 19115940 156 LA 157
Cdd:cd17374 112 LG 113
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
62-222 2.70e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 2.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  62 FAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFS 141
Cdd:COG2807  37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 142 GLFGSVGLSNGSGSLADLFEKKdRGKYMVIYFTVLSIGPGIAPIISGFISQSSiGWQWEFWILLILSGFNLFWAFLLLKE 221
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAAL-GWRGALAVWALLALLALLLWLPLLRR 194


                .
gi 19115940 222 T 222
Cdd:COG2807 195 R 195
2A0112 TIGR00891
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...
 65-222 3.94e-06

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273324 [Multi-domain]  Cd Length: 405  Bit Score: 49.11  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    65 SISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLF 144
Cdd:TIGR00891  34 VLAEVAGEFGLTTVDAASLISAALISRWFGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGIG 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19115940   145 GSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPII-SGFISQSSIGWQWEFWILLILSGFNLFWAfLLLKET 222
Cdd:TIGR00891 114 MGGEYGSSAAYVIESWPKHLRNKASGLLISGYAVGAVVAAQVySLVVPVWGDGWRALFFISILPIIFALWLR-KNIPEA 191
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 52-404 5.85e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.38  E-value: 5.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  52 TFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIAL---- 127
Cdd:cd06173   8 QLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlall 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 128 -SVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGK----YMVIYFTVLSIGPGIAPIISGFisqssIGWQWEFW 202
Cdd:cd06173  88 gSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRanalNSLATQLARIIGPALGGLLVAL-----LGPGGAFA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 203 ILLILSGFnLFWAFLLLKETYPPVLNRKKFEKYGEIGEnepvALRLTGKQLLIKllillsmkkpisillsqpILICVACT 282
Cdd:cd06173 163 INALSFLL-SALLLLFIRRPPPAAPGESSSLLLRDLRE----GLRYLRRSPLLR------------------LLLLALAL 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 283 IGSIYGMINLVLIAFSEVWkssYDFSPGISGLMYISITLGLFSAVFIAmpinqkfySYLVKRNGgegepefRLPMGFIGI 362
Cdd:cd06173 220 FALLGGALTVLLPLLAKEV---LGGGAAGYGLLLAAFGVGALLGALLL--------GRLSKRRR-------RGRLLLIGA 281

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 19115940 363 TLFEIGILLFGWTArykiFWFVPTIGSAIMGGGYIMTSNPLN 404
Cdd:cd06173 282 LLLGLALLVLGLSP----SLWLLLAALFLLGLAGGLFNVPLN 319
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 92-225 8.46e-06

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 47.88  E-value: 8.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  92 LFGNLIFAPLSEQFGRRPIYLI---GYSVFALLQIPIA-LSVNLAMFLVFRFFSGLFGSVG--LSNGSGSLADLFEKKDR 165
Cdd:cd17449  79 LFSVTLLGPWSDSVGRRPVLILpslGLALQAAVYLLVMyLQLHVAYFLIGRILSGLLGDFNgiLAGCFAYVADVSDRRSR 158

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 166 GKYMVIYFTVLSIGPGIAPIISGFISQSSiGWQWEFWILLILSGFNLFWAFLLLKETYPP 225
Cdd:cd17449 159 TFRVAVLEACLGLAGMLASIIGGQWRKAQ-GYINPFWLVLALNLAAALYAAFCVGESVKE 217
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 89-227 2.08e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 46.49  E-value: 2.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  89 LGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFsglfgsVGLSNGSGS------LADLFEK 162
Cdd:cd17360  46 AGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVL------VGLGVGIASmtvplyIAEAAPP 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19115940 163 KDRGKYMVIYFTVLSIGPGIAPIISGFISQSSIGWQWEFWILLILSGFNLFwAFLLLKET--YPPVL 227
Cdd:cd17360 120 RIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFI-GLLFLPESprWPSTR 185
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 60-232 3.55e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 46.01  E-value: 3.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:cd17478  13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 140 FSGlFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFI--SQSSIGWQWEFWILLILSGFNLFWAFL 217
Cdd:cd17478  93 LAG-IGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALvaLFGGLGLLILLIIPGLAVALLLLRLRP 171

                       170
                ....*....|....*
gi 19115940 218 LLKETYPPVLNRKKF 232
Cdd:cd17478 172 LKKPEAKKAAAKSSA 186
MFS_1 pfam07690
Major Facilitator Superfamily;
40-184 6.62e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.10  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940    40 LKVRNVIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFA 119
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115940   120 LLQIPIAL---SVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAP 184
Cdd:pfam07690 277 LAALGLLLlslTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 89-143 1.75e-04

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 43.68  E-value: 1.75e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19115940  89 LGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGL 143
Cdd:cd17444  47 VGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGF 101
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 60-206 1.79e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.83  E-value: 1.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  60 SVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRF 139
Cdd:cd17371  16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 140 FSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQ---SSIGWQWEFWILLI 206
Cdd:cd17371  96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllpPEIAWRVLFLLGAL 165
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
71-220 1.88e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 1.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  71 EQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLS 150
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP 318

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 151 NGSGSLADLFeKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSsIGWQWEFWILLILSGFNLFWAFLLLK 220
Cdd:COG0738 319 TIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA-FGLRAAFLVPLVCYLLILLLALALKR 386
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 40-208 2.28e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.36  E-value: 2.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  40 LKVRNVIVISSMTFLNQYGDSVFAPS-ISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQ-FGRRPIYLIGYSV 117
Cdd:cd17490 191 LKDKKLLFFSLLAILQQMITFSTTFGfTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKkLGERNTIIIGFLL 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 118 FALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGW 197
Cdd:cd17490 271 LGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISE-AFGL 349

                       170
                ....*....|.
gi 19115940 198 QWEFWILLILS 208
Cdd:cd17490 350 QTGFFVIGVIA 360
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 88-215 2.59e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 2.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  88 TLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGK 167
Cdd:cd17473 243 SLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGR 322

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 19115940 168 YMVIYFTVLSIGPGIAPIISGFISQSSIG----WQWEFWILLILSGFNLFWA 215
Cdd:cd17473 323 AMGIVTSAFFLGQFLSPLVLGPLVNLTGGlsgaFLILGVLALVLAIVLLLLR 374
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 57-222 2.73e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.06  E-value: 2.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  57 YGDSVFAPSISNIAEQFHASRTLVTLGATLytLGILFGNLIFAPLSEQFGRRPIYLIGY-----SVFALLQIPIALSVNL 131
Cdd:cd17371 226 YGITTWLPSYLTGERGLSFEGSAGYLVVTI--LGGFLGYLAGGFLADRIGRRNNFALFAlgsaiSILLYFFLPLSPTLIL 303

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 132 -AMFLVFRFFSGLFGSVGLsngsgSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQWEFWILLILSGF 210
Cdd:cd17371 304 iLGFPLGFFASGPFSGMGA-----YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA-TSGSLGTAIAVFAAVYYI 377

                       170
                ....*....|..
gi 19115940 211 NLFWAFLLLKET 222
Cdd:cd17371 378 AGLVLALLLPET 389
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 76-392 2.97e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.95  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  76 SRTLVTLGATLYTLGILF-----GNLIFAP----LSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGS 146
Cdd:cd17330  23 VREFNKLGASGYYVGLLQssyslGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 147 vGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISQSsIGWQWEFWILLILSGFNLFWAFLLLKETYPPV 226
Cdd:cd17330 103 -NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP-YGYALPFLVAAALALLNLVLVLFFLPPLRRLL 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 227 LNRKKFEkYGEIGENEPVALRLT-----GKQLLIKLLILLSMKKPISILLSQPILIC-----VACTIGSIYGMINLVLIA 296
Cdd:cd17330 181 LVYFLIA-LAFAGLESVFSLFLKdrfgfSPSQIGLLLALVGIAGILAQLLLIPRLAKrlgerKLLRLGLLLAIIGLLLLP 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 297 FSevwkssydfsPGISGLMYISITLGLFSAVFIAMpinqkFYSYLVKRNGgegEPEFRLPMGFI----GITLFeIGILLF 372
Cdd:cd17330 260 FA----------SSVPLLVLAAAILAFGTGIVFPA-----LSALLSKSVP---SKEQGKAQGIIqslqSLARI-IGPLLA 320

                       330       340
                ....*....|....*....|
gi 19115940 373 GWTARYKIFWFVPTIGSAIM 392
Cdd:cd17330 321 GPLYSFLGPGVPFLLAAGLL 340
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 80-142 3.48e-04

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 42.89  E-value: 3.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115940  80 VTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSG 142
Cdd:cd17373  27 VHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEG 89
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 108-224 4.80e-04

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 42.39  E-value: 4.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 108 RPIYLIGYSVFA--LLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSIGPGIAPI 185
Cdd:cd17488  66 NPRYFMGIGLIAtgIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPI 145

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19115940 186 ISGFISQSSiGWQWEFWILLILSGFNLFWAFLLLKETYP 224
Cdd:cd17488 146 LTGFAALTY-GWRAGMYVPGIIAILMGIVLCWRLRDRPP 183
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 45-216 6.07e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.87  E-value: 6.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAP----LSEQFGRRPIYLIGYSVFAL 120
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPrlgkLGDRIGHHRILLGALLASAL 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 121 LQIPIALSVNLAMFLVFRFFSGLfgSVGLSNGS--GSLADLFEKKDRGKYMVIYFTVLSIGPGIAPIISGFISqSSIGWQ 198
Cdd:cd17391 283 LYIPQAFVQTPWQLGILRFLLGL--ATGGLLPAinSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIA-AHFGYR 359

                       170
                ....*....|....*...
gi 19115940 199 WEFWILLILSGFNLFWAF 216
Cdd:cd17391 360 AVFVVTALLVLLNAIWSF 377
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 101-219 1.19e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 41.07  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 101 LSEQFGRRPIYLIGYSVFALLQ--IPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTVLSI 178
Cdd:cd17318  79 LAEKYGAKRVLGYSILITALLTllTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 19115940 179 GPGIAPIISGFISqSSIGWQWEFWILLILS-GFNLFWAFLLL 219
Cdd:cd17318 159 GTVIAMPLSGFLC-ESLGWPSIFYIFGGLGlLWCLLWFFLVL 199
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 53-143 1.55e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 40.63  E-value: 1.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  53 FLNQYGDSVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLA 132
Cdd:cd17359  11 LLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT 90

                        90
                ....*....|.
gi 19115940 133 MFLVFRFFSGL 143
Cdd:cd17359  91 IFIIARIIGGL 101
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 62-223 1.59e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 40.70  E-value: 1.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  62 FAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIgysVFALLQIPIALS----VNLAMFLVF 137
Cdd:cd17341  18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIA---SLLLLLIPLLALalavSSYWGLLVL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 138 RFFSGLFG---SVGLSNGSGsladLFEKKDRGKYMVIYFTVLSIGPGI----APIISGFISQ--SSIGWQWEFWILLILS 208
Cdd:cd17341  95 GFLLGFAGanfASGQPWASF----WFPKEKIGGAAGGIAGAGNMGVAVsqllAPLIAGAIVFdgGFVGWRNAFFVPGILL 170

                       170
                ....*....|....*
gi 19115940 209 GFNLFWAFLLLKETY 223
Cdd:cd17341 171 AIAAVLVLLFGDDLP 185
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 96-208 1.89e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 1.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  96 LIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTV 175
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTV 331

                        90       100       110
                ....*....|....*....|....*....|...
gi 19115940 176 LSIGPGIAPIISGFISQsSIGWQWEFWILLILS 208
Cdd:cd17370 332 VGIGWLLASLIAGYLWD-LISPSAAFLFSAVLA 363
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
107-470 1.92e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.66  E-value: 1.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 107 RRPIYLIGYSVFALLQI------PIALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLF-EKKDRGKYMVIYFTVLSIG 179
Cdd:COG2211  80 RRPWILIGAIPLALSFVllftapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTpDYEERTRLSSWRFAFAGLG 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 180 PGIAPIISGFI-----SQSSIGWQWEFWILLILSGFNLFWAFLLLKETYPPVLNRKKFekygeigenepvalrltgkqll 254
Cdd:COG2211 160 GLLASVLPPPLvaafgGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSL---------------------- 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 255 ikllillsmKKPISILLSQPILICVACTIGSIYGMINLVLIAFSEVWKSSYDFSPGISGLMYISITLglfsAVFIAMPin 334
Cdd:COG2211 218 ---------KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFL----AALLGAP-- 282

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 335 qkFYSYLVKRNGgegepefRLPMGFIGITLFEIGILLFGWTARYKIFWFVptIGSAIMGGGY-IMTSNPLNMY--VVD-- 409
Cdd:COG2211 283 --LWPRLAKRFG-------KKKAFIIGLLLAALGLLLLFFLGPGNLWLLL--VLAALAGIGLgAILVLPWAMLadVVDyd 351

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115940 410 -------SYGIYSASASAGVKIFQLLLGAIFPL------FAESLFRRLNYGWGCTLLAFIL--LACGCSLPILFKY 470
Cdd:COG2211 352 ewktgrrREGLYFGIFTFAIKLGQALAGALAGLllalfgYVAGAAQSPSALTGIRLLFFLLpaVLLLLAALLLLFY 427
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 45-219 2.33e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 40.31  E-value: 2.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  45 VIVISSMTFLNQYGD--SVFAPSISNIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRR---PIYLIGYSVFA 119
Cdd:cd17327   6 ILPLLCILYFLQYLDksNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSkwlSVFIVLWGLLT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 120 LLQipiALSVNLAMFLVFRFFSGLFGSVGLSNGSGSLADLFEKKDRGKYMVIYFTvlsiGPGIAPIISGFISQSSI---- 195
Cdd:cd17327  86 LLT---AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYA----AAGLGSIFGGLLAYGVFkilg 158

                       170       180
                ....*....|....*....|....*....
gi 19115940 196 -----GWQWEFWILLILSGFNLFWAFLLL 219
Cdd:cd17327 159 vgglaGWRWLFIIEGLITIIIGLVIFFWL 187
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 56-219 3.42e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.56  E-value: 3.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  56 QYGDSVFAPsisnIAEQFHASRTLVTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFL 135
Cdd:cd17355  20 YYFGVFIIP----IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 136 VFRFFSGLFGSVGLSNGSGSLADL--FEKKdRGKYMVIYFTVLSIGPGI-APIISGFISQssIGWQWEFWILLILSGFNL 212
Cdd:cd17355  96 LLWGLLGGGGAGTLAAVAFATVAAwwFERR-RGLALGILTAGGGLGSLVfLPLGAALIEA--FGWRTALLVLALLALLVL 172


                ....*..
gi 19115940 213 FWAFLLL 219
Cdd:cd17355 173 VPVLLLL 179
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 88-143 4.41e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 39.18  E-value: 4.41e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19115940   88 TLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGL 143
Cdd:PRK11551  60 ILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 53-224 4.75e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.09  E-value: 4.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  53 FLNQYGDSVFAPSISNIAEQFHASRTLVTLGATL--YTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVN 130
Cdd:cd17315   7 LLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVssLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940 131 LAMFLVFRFFSGLFgsVGLSNGSGSL--ADLFEKKDRGKYMVIYFTVLSIGPGIAPIIS-GFISQSSIGWQWEFWILLIL 207
Cdd:cd17315  87 VWVLIVGRFLLGLG--VGLASVLVPLyiSEIAPAKIRGALGTLNQLMITFGILLAYLLGlALSLSPPGWWRLMFALAAVP 164

                       170
                ....*....|....*..
gi 19115940 208 SGFnLFWAFLLLKETYP 224
Cdd:cd17315 165 ALL-QLLLMFFLPESRA 180
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 92-220 5.66e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 38.80  E-value: 5.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115940  92 LFGNLIFAPLSEQFGRRP---IYLIGYSVFALLQIPIALSVNLAMFLVF---RFFSGLFGS-VGLSNGSGSL-ADLFEKK 163
Cdd:cd17386  44 LFSSLFLGSWSDRYGRKPpllMSLVGLLLSSLILVLIVYFTTVPSVWWFylsAIPLALFGGfTAFLSASFAYiSDISSEK 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19115940 164 DRGKYMVIYFTVLSIGPGIAPIISGFISQsSIGWQWEFWILLILSGFNLFWAFLLLK 220
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFK-ALGYAWSFSISAALLLIALLYILFFLT 179
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 80-145 6.83e-03

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 38.60  E-value: 6.83e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19115940  80 VTLGATLYTLGILFGNLIFAPLSEQFGRRPIYLIGYSVFALLQIPIALSVNLAMFLVFRFFSGLFG 145
Cdd:cd17376  37 VPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQ 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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