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Conserved domains on  [gi|19924156|ref|NP_604389|]
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DNA-binding protein RFXANK isoform b [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
94-226 6.56e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 6.56e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
Cdd:COG0666 113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19924156 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 226
Cdd:COG0666 193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
94-226 6.56e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 6.56e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
Cdd:COG0666 113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19924156 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 226
Cdd:COG0666 193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-195 1.14e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 1.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   105 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 184
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 19924156   185 ALLARGADLTT 195
Cdd:pfam12796  79 LLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-209 3.65e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 3.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 153
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19924156  154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 209
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 166-194 5.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.03e-04
                           10        20
                   ....*....|....*....|....*....
gi 19924156    166 NGGTPLLYAVRGNHVKCVEALLARGADLT 194
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-195 2.49e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156 103 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 174
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96

                        90       100
                ....*....|....*....|.
gi 19924156 175 VRGNHVKCVEALLARGADLTT 195
Cdd:cd22192  97 VVNQNLNLVRELIARGADVVS 117
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
94-226 6.56e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.23  E-value: 6.56e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
Cdd:COG0666 113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL 192

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19924156 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKL 226
Cdd:COG0666 193 AAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
88-215 6.56e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.83  E-value: 6.56e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  88 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
Cdd:COG0666  74 LAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG 153

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19924156 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
Cdd:COG0666 154 NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
94-231 3.15e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.81  E-value: 3.15e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
Cdd:COG0666 146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19924156 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNL 231
Cdd:COG0666 226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
70-215 7.81e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 7.81e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI 149
Cdd:COG0666  23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19924156 150 VGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
Cdd:COG0666 103 VKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEI 168
Ank_2 pfam12796
Ankyrin repeats (3 copies);
105-195 1.14e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 1.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   105 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERdVDINIYDwNGGTPLLYAVRGNHVKCVE 184
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|.
gi 19924156   185 ALLARGADLTT 195
Cdd:pfam12796  79 LLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
94-204 3.59e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.15  E-value: 3.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
Cdd:COG0666 179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                        90       100       110
                ....*....|....*....|....*....|.
gi 19924156 174 AVRGNHVKCVEALLARGADLTTEADSGYTPM 204
Cdd:COG0666 259 AAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-209 3.65e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.93  E-value: 3.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPLIWASA--FGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDI------------------VGLL 153
Cdd:PHA03100  99 VNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYL 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19924156  154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVA 209
Cdd:PHA03100 179 LSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-223 8.10e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 8.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   138 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAdlTTEADSGYTPMDLAVALGYRK-VQ 216
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEiVK 78


                  ....*..
gi 19924156   217 QVIENHI 223
Cdd:pfam12796  79 LLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 88-221 4.44e-14

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 70.76  E-value: 4.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   88 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 19924156  168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 221
Cdd:PHA02874 191 ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINN 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
88-215 6.10e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 6.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  88 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
Cdd:COG0666   8 LLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGG 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19924156 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
Cdd:COG0666  88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 113-230 4.50e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.60  E-value: 4.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  113 EIETVRFLLEWGADPHILAKERESALSLASTGGYT-----DIVGLLLERDVDINIYDWNGGTPLLYAV--RGNHVKCVEA 185
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEY 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 19924156  186 LLARGADLTTEADSGYTPmdLAVALGYRKvqqvIENHILKLFQSN 230
Cdd:PHA03100 127 LLDNGANVNIKNSDGENL--LHLYLESNK----IDLKILKLLIDK 165
Ank_2 pfam12796
Ankyrin repeats (3 copies);
88-164 1.46e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.28  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156    88 LDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEwgadpHILAKER---ESALSLASTGGYTDIVGLLLERDVDINIYD 164
Cdd:pfam12796  17 LENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKdngRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 99-192 4.99e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.85  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKG 179

                         90
                 ....*....|....
gi 19924156  179 HVKCVEALLARGAD 192
Cdd:PHA02875 180 DIAICKMLLDSGAN 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 113-221 2.02e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.90  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  113 EIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 192
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         90       100       110
                 ....*....|....*....|....*....|
gi 19924156  193 LTTEADSGYTPMDLAVALG-YRKVQQVIEN 221
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGdYACIKLLIDH 212
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 126-228 7.34e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.29  E-value: 7.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  126 DP---HILAKEresALSLASTGgytDIVG--LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
Cdd:PTZ00322  75 DPvvaHMLTVE---LCQLAASG---DAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDG 148

                         90       100
                 ....*....|....*....|....*...
gi 19924156  201 YTPMDLAVALGYRKVQQVIENHILKLFQ 228
Cdd:PTZ00322 149 KTPLELAEENGFREVVQLLSRHSQCHFE 176
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-162 1.85e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.90  E-value: 1.85e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19924156   94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 113-226 2.69e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.73  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  113 EIETVRFLLEWGADPHILAKER-ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 191
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 19924156  192 DLTTEADSGYTPMDLAVAlgyrkvqQVIENHILKL 226
Cdd:PHA02878 226 STDARDKCGNTPLHISVG-------YCKDYDILKL 253
Ank_5 pfam13857
Ankyrin repeats (many copies);
152-207 5.07e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.11  E-value: 5.07e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19924156   152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 101-222 9.84e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 9.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN--IYDwNGGTPLLYAVRGN 178
Cdd:PHA02875  35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADdvFYK-DGMTPLHLATILK 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 19924156  179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
Cdd:PHA02875 114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 117-209 1.49e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.18  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  117 VRFLLEWGADPHILAKERESALSLASTGGYTD--IVGLLLERDVDINIYDWNGGTPLLYA-VRGNHVKCVEaLLARGADL 193
Cdd:PHA03095 205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAaVFNNPRACRR-LIALGADI 283

                         90
                 ....*....|....*.
gi 19924156  194 TTEADSGYTPMDLAVA 209
Cdd:PHA03095 284 NAVSSDGNTPLSLMVR 299
Ank_4 pfam13637
Ankyrin repeats (many copies);
134-187 3.18e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 3.18e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 19924156   134 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-225 3.35e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGAdpHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNRSAIELLINNASINDQDIDGSTPLHH 260

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 19924156  174 AVRGN-HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK--VQQVIENHILK 225
Cdd:PHA02874 261 AINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDpvIKDIIANAVLI 315
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 94-208 4.87e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 4.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDE-RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLL 172
Cdd:PHA02878 160 INMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH 239

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 19924156  173 YAV-RGNHVKCVEALLARGADLTTEAD-SGYTPMDLAV 208
Cdd:PHA02878 240 ISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI 277
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 95-154 5.76e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 5.76e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 109-187 5.98e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 5.98e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19924156  109 SAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 92-208 7.00e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 7.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL------------------ 153
Cdd:PHA02874  26 NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLidngvdtsilpipciekd 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  154 -----LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAV 208
Cdd:PHA02874 106 miktiLDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAI 165
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 59-162 7.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 7.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SA 137
Cdd:PHA02875 126 ADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAA 205

                         90       100
                 ....*....|....*....|....*
gi 19924156  138 LSLASTGGYTDIVGLLLERDVDINI 162
Cdd:PHA02875 206 LCYAIENNKIDIVRLFIKRGADCNI 230
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-205 1.01e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPL-IWASAFGE--IETVRFLLEWGADphILAKER--ESALSLASTGGYT-DIVGLLLERDVDINIYDWNG 167
Cdd:PHA03095  40 VNFRGEYGKTPLhLYLHYSSEkvKDIVRLLLEAGAD--VNAPERcgFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVG 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 19924156  168 GTPL-LYAVRGN-HVKCVEALLARGADLTTEADSGYTPMD 205
Cdd:PHA03095 118 RTPLhVYLSGFNiNPKVIRLLLRKGADVNALDLYGMTPLA 157
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 84-193 1.07e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   84 LPATLDCDNLVNKPDERGFTPLIWASAFG-EIETVRFLLEWGADPHILAKERESALSLAST-GGYTDIVGLLLERDVDIN 161
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN 369

                         90       100       110
                 ....*....|....*....|....*....|..
gi 19924156  162 IYDWNGGTPLLYAVRGNHVKCVEALLARGADL 193
Cdd:PHA02876 370 ARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 94-219 1.56e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERgfTPLIWASAFGEIETVRFLLEWG--ADpHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 171
Cdd:PHA02875  63 VKYPDIE--SELHDAVEEGDVKAVEELLDLGkfAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPL 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 19924156  172 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 94-232 2.22e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.14  E-value: 2.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESAL--SLASTGGYTDiVGLLLERDVDINIYDWNGGTPL 171
Cdd:PHA02876 368 VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhfALCGTNPYMS-VKTLIDRGANVNSKNKDLSTPL 446

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924156  172 LYAVRGN-HVKCVEALLARGADLTTEADSGYTPmdLAVALGYRKVQQVIENHILKLFQSNLV 232
Cdd:PHA02876 447 HYACKKNcKLDVIEMLLDNGADVNAINIQNQYP--LLIALEYHGIVNILLHYGAELRDSRVL 506
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 65-212 2.43e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   65 SLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTG 144
Cdd:PHA02876 142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDS 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  145 GYTDIVGLLLERDVDINIYD------------------WNGG-----------TPLLYAVRGNHV-KCVEALLARGADLT 194
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKNDlsllkairnedletslllYDAGfsvnsiddcknTPLHHASQAPSLsRLVPKLLERGADVN 301

                        170
                 ....*....|....*...
gi 19924156  195 TEADSGYTPMDLAVALGY 212
Cdd:PHA02876 302 AKNIKGETPLYLMAKNGY 319
Ank_5 pfam13857
Ankyrin repeats (many copies);
120-174 2.70e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 2.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19924156   120 LLEWG-ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
103-154 2.91e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 2.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19924156   103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
90-141 4.27e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 4.27e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19924156    90 CDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 141
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 66-212 5.50e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 5.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   66 LKHSTTLtnrqRGNEVSALPAtldcDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGG 145
Cdd:PLN03192 498 LQHHKEL----HDLNVGDLLG----DNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKG 569

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  146 YTDIVGLLLERDVDINIYDWNGGTPL--------------LY-----------------AVRGNHVKCVEALLARGADLT 194
Cdd:PLN03192 570 YEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifriLYhfasisdphaagdllctAAKRNDLTAMKELLKQGLNVD 649

                        170
                 ....*....|....*...
gi 19924156  195 TEADSGYTPMDLAVALGY 212
Cdd:PLN03192 650 SEDHQGATALQVAMAEDH 667
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-199 8.64e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 8.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGAdphilakeresalslastggytdivglllerdvDINIYDWNGGTPLLY 173
Cdd:PHA03095 250 INARNRYGQTPLHYAAVFNNPRACRRLIALGA---------------------------------DINAVSSDGNTPLSL 296

                         90       100
                 ....*....|....*....|....*.
gi 19924156  174 AVRGNHVKCVEALLARGADLTTEADS 199
Cdd:PHA03095 297 MVRNNNGRAVRAALAKNPSAETVAAT 322
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 79-214 1.28e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   79 NEVSALPATLDCDNLVNKPDergfTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLAS-TGGYTDIVGLLLERD 157
Cdd:PHA02876 222 KNIDTIKAIIDNRSNINKND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERG 297

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19924156  158 VDINIYDWNGGTPL-LYAVRGNHVKCVEALLARGADLTTeADSGY-TPMDLAVALGYRK 214
Cdd:PHA02876 298 ADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA-ADRLYiTPLHQASTLDRNK 355
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 100-129 2.56e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.56e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 19924156   100 RGFTPLIWASA-FGEIETVRFLLEWGADPHI 129
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNA 31
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 166-194 5.03e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 5.03e-04
                           10        20
                   ....*....|....*....|....*....
gi 19924156    166 NGGTPLLYAVRGNHVKCVEALLARGADLT 194
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 166-193 7.27e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 7.27e-04
                          10        20
                  ....*....|....*....|....*...
gi 19924156   166 NGGTPLLYAVRGNHVKCVEALLARGADL 193
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 166-193 9.34e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 9.34e-04
                          10        20
                  ....*....|....*....|....*....
gi 19924156   166 NGGTPLLYAV-RGNHVKCVEALLARGADL 193
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADV 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
167-215 1.53e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 19924156   167 GGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEV 49
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 103-195 2.49e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156 103 TPLIWASAFGEIETVRFLLEW-GADPHILAKERESALSLASTGGYTDIVGLLLERDVD-IN------IYDwnGGTPLLYA 174
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCpSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNepmtsdLYQ--GETALHIA 96

                        90       100
                ....*....|....*....|.
gi 19924156 175 VRGNHVKCVEALLARGADLTT 195
Cdd:cd22192  97 VVNQNLNLVRELIARGADVVS 117
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 100-129 2.67e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 2.67e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 19924156   100 RGFTPLIWASAFGEIETVRFLLEWGADPHI 129
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02791 PHA02791
ankyrin-like protein; Provisional
 96-201 2.95e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 38.10  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   96 KPDERGFTPLIWASAFGEIETVRFLLEWGADPHILakERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAV 175
Cdd:PHA02791  25 KADVHGHSALYYAIADNNVRLVCTLLNAGALKNLL--ENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAV 102

                         90       100
                 ....*....|....*....|....*.
gi 19924156  176 RGNHVKCVEALLARGADLTTEADSGY 201
Cdd:PHA02791 103 DSGNMQTVKLFVKKNWRLMFYGKTGW 128
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 88-233 3.26e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156  88 LDCD-NLVNKPDE----RGFTPLIWASAFGEIETVRFLLEWGAD--------------PHILAKERESALSLASTGGYTD 148
Cdd:cd22192  71 MEAApELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADvvspratgtffrpgPKNLIYYGEHPLSFAACVGNEE 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156 149 IVGLLLERDVDINIYDWNGGTPL-LYAVRGNHVKCVEA---LLARGADLTTEA------DSGYTPMDLAVALGyrkvQQV 218
Cdd:cd22192 151 IVRLLIEHGADIRAQDSLGNTVLhILVLQPNKTFACQMydlILSYDKEDDLQPldlvpnNQGLTPFKLAAKEG----NIV 226

                       170
                ....*....|....*...
gi 19924156 219 IENHIL---KLFQSNLVP 233
Cdd:cd22192 227 MFQHLVqkrRHIQWTYGP 244
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 94-176 4.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.94  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924156   94 VNKPDERGFTPL-IWASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGgyTDIVGLLLERDVDINIYDWNGGTPL 171
Cdd:PHA02878 227 TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPL 304


                 ....*
gi 19924156  172 LYAVR 176
Cdd:PHA02878 305 SSAVK 309
PHA02792 PHA02792
ankyrin-like protein; Provisional
 159-223 4.67e-03

ankyrin-like protein; Provisional


Pssm-ID: 165155 [Multi-domain]  Cd Length: 631  Bit Score: 38.01  E-value: 4.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19924156  159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 223
Cdd:PHA02792 402 DINKIDKHGRSILYYCIESHSVSLVEWLIDNGADINITTKYGSTCIGICVILAHACIPEIAELYI 466
PHA03095 PHA03095
ankyrin-like protein; Provisional
 148-206 6.85e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.31  E-value: 6.85e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19924156  148 DIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC---VEALLARGADLTTEADSGYTPMDL 206
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVkdiVRLLLEAGADVNAPERCGFTPLHL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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