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Conserved domains on  [gi|24475816|ref|NP_612510|]
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very-long-chain enoyl-CoA reductase isoform 1 [Homo sapiens]

Protein Classification

steroid 5-alpha reductase family protein( domain architecture ID 708466)

steroid 5-alpha reductase family protein similar to Homo sapiens very-long-chain enoyl-CoA reductase and trans-2,3-enoyl-CoA reductase-like

EC:  1.3.1.-
Gene Ontology:  GO:0016491|GO:0042761

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02560 super family cl28409
enoyl-CoA reductase
 23-305 1.50e-86

enoyl-CoA reductase


The actual alignment was detected with superfamily member PLN02560:

Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 261.97  E-value: 1.50e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   23 VEPHATIAEIKNLFTKTHPQWYPARQSLRLD-PKGKS----LKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAG 97
Cdd:PLN02560  20 VPDSATVADLKKAIHKRKKKYYPSRQRLTLPlPPGKTrptvLDDSKSLKDYGLGDGGTVVFKDLGPQVSYRTLFFFEYLG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   98 PLFIYLLFYFrVPFIYGH-KYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMA 176
Cdd:PLN02560 100 PLLIYPLFYF-FPQVYKYfGYPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWTFGAYIA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816  177 YYINHPLYTPPtyGAQQVKLALAIFVICQLGNFSIHMALRDLR-PAGSKTRKIPYptknpfTWLFLLVSCPNYTYEVGSW 255
Cdd:PLN02560 179 YFVNHPLYTPV--SETQMKVGFGFGLVCQLANFYCHIILRNLRkPDGKGGYQIPR------GFLFNYVTCANYTTEIYQW 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24475816  256 IGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEF-----RDYPPLRMPIIP 305
Cdd:PLN02560 251 LGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFdgkdgRPKYPRRWVILP 305
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 23-305 1.50e-86

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 261.97  E-value: 1.50e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   23 VEPHATIAEIKNLFTKTHPQWYPARQSLRLD-PKGKS----LKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAG 97
Cdd:PLN02560  20 VPDSATVADLKKAIHKRKKKYYPSRQRLTLPlPPGKTrptvLDDSKSLKDYGLGDGGTVVFKDLGPQVSYRTLFFFEYLG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   98 PLFIYLLFYFrVPFIYGH-KYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMA 176
Cdd:PLN02560 100 PLLIYPLFYF-FPQVYKYfGYPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWTFGAYIA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816  177 YYINHPLYTPPtyGAQQVKLALAIFVICQLGNFSIHMALRDLR-PAGSKTRKIPYptknpfTWLFLLVSCPNYTYEVGSW 255
Cdd:PLN02560 179 YFVNHPLYTPV--SETQMKVGFGFGLVCQLANFYCHIILRNLRkPDGKGGYQIPR------GFLFNYVTCANYTTEIYQW 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24475816  256 IGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEF-----RDYPPLRMPIIP 305
Cdd:PLN02560 251 LGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFdgkdgRPKYPRRWVILP 305
Ubl_TECR cd17124
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed ...
 3-81 1.20e-56

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR homolog (TSC13p) is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340644 [Multi-domain]  Cd Length: 79  Bit Score: 177.45  E-value: 1.20e-56
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24475816   3 HYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDL 81
Cdd:cd17124   1 FFEVEILDAKTKEKLCFLDKVEPNATIGEIKNLFHKSHPQWYPARQSLRLDPKGKSLKDEDILQNLPVGTTATFYFRDL 79
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 155-308 8.24e-28

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 105.18  E-value: 8.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   155 TMPLRNIFKNCTY--YWGF--AAWMAYYinhPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPy 230
Cdd:pfam02544   2 TMPLTIVAKAFAFctLNGLiqGRYNSYY---QPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIP- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24475816   231 ptknpFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL 308
Cdd:pfam02544  78 -----RGGLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
 
Name Accession Description Interval E-value
PLN02560 PLN02560
enoyl-CoA reductase
 23-305 1.50e-86

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 261.97  E-value: 1.50e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   23 VEPHATIAEIKNLFTKTHPQWYPARQSLRLD-PKGKS----LKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAG 97
Cdd:PLN02560  20 VPDSATVADLKKAIHKRKKKYYPSRQRLTLPlPPGKTrptvLDDSKSLKDYGLGDGGTVVFKDLGPQVSYRTLFFFEYLG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   98 PLFIYLLFYFrVPFIYGH-KYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMA 176
Cdd:PLN02560 100 PLLIYPLFYF-FPQVYKYfGYPARRVIHPVQTYAMYYWCFHYAKRILETFFVHRFSHATSPLFNVFRNCAYYWTFGAYIA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816  177 YYINHPLYTPPtyGAQQVKLALAIFVICQLGNFSIHMALRDLR-PAGSKTRKIPYptknpfTWLFLLVSCPNYTYEVGSW 255
Cdd:PLN02560 179 YFVNHPLYTPV--SETQMKVGFGFGLVCQLANFYCHIILRNLRkPDGKGGYQIPR------GFLFNYVTCANYTTEIYQW 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24475816  256 IGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEF-----RDYPPLRMPIIP 305
Cdd:PLN02560 251 LGFNIATQTVAGYLFLAVAAAIMTNWALAKHRRLKKLFdgkdgRPKYPRRWVILP 305
Ubl_TECR cd17124
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed ...
 3-81 1.20e-56

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR); TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR homolog (TSC13p) is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340644 [Multi-domain]  Cd Length: 79  Bit Score: 177.45  E-value: 1.20e-56
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24475816   3 HYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDL 81
Cdd:cd17124   1 FFEVEILDAKTKEKLCFLDKVEPNATIGEIKNLFHKSHPQWYPARQSLRLDPKGKSLKDEDILQNLPVGTTATFYFRDL 79
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 155-308 8.24e-28

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 105.18  E-value: 8.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816   155 TMPLRNIFKNCTY--YWGF--AAWMAYYinhPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPy 230
Cdd:pfam02544   2 TMPLTIVAKAFAFctLNGLiqGRYNSYY---QPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIP- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24475816   231 ptknpFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL 308
Cdd:pfam02544  78 -----RGGLFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
Ubl_TECR_like cd01801
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; ...
 5-81 1.02e-24

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase (TECR) and similar proteins; This family includes TECR and many TECR-like proteins, such as TECRL. TECR, also termed very-long-chain enoyl-CoA reductase, or synaptic glycoprotein SC2, or TER, or GPSN2, is a synaptic glycoprotein that catalyzes the fourth reaction in the synthesis of very long-chain fatty acids (VLCFA) which is the reduction step of the microsomal fatty acyl-elongation process. Diseases involving perturbations to normal synthesis and degradation of VLCFA (e.g. adrenoleukodystrophy and Zellweger syndrome) have significant neurological consequences. The mammalian TECR P182L mutation causes nonsyndromic mental retardation. Deletion of the yeast TECR (TSC13) homolog is lethal. TECR contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain. TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life-threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). Both TECR and TECRL contain an N-terminal Ubl domain with a beta-grasp Ubl fold, and a C-terminal catalytic domain.


Pssm-ID: 340499 [Multi-domain]  Cd Length: 77  Bit Score: 94.66  E-value: 1.02e-24
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24475816   5 EVEILDAKTReKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLD-PKGKSLKDEDVLQKLPVGTTATLYFRDL 81
Cdd:cd01801   1 KIEVVSRKGG-KQIITLEVSSSATVADLKKAIHKKKKKLYPERQRLRLEvPKGKVLKDDKTLSSYGVKDGSTLYFKDL 77
Ubl_TECRL cd17125
ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also ...
 4-81 7.32e-23

ubiquitin-like (Ubl) domain found in trans-2,3-enoyl-CoA reductase-like (TECRL); TECRL, also termed steroid 5-alpha-reductase 2-like 2 protein (SRD5A2L2), is associated with life?threatening inherited arrhythmias displaying features of both long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). TECRL contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal catalytic domain.


Pssm-ID: 340645  Cd Length: 78  Bit Score: 89.92  E-value: 7.32e-23
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24475816   4 YEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDL 81
Cdd:cd17125   1 FEVEILDAQTRKQICVVDKVHPSSTILDVKIKFHKTCPQWYPSRVGLQLERNGPFLKDSCEIQSIAVSSIVTLYFTDL 78
PLN02392 PLN02392
probable steroid reductase DET2
 233-307 2.14e-07

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 50.96  E-value: 2.14e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24475816  233 KNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEF-RDYPPLRMPIIPFL 307
Cdd:PLN02392 184 KVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLEKFgEDYPKGRKAVIPFL 259
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
 196-307 7.61e-05

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 43.65  E-value: 7.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24475816  196 LALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWlfllVSCPNYTYEVGSWIG--FAIMTQCLPVALFSLV 273
Cdd:PLN03164 213 IGAAIFLWGWIHQYRCHAILGSLREHKKQADEYVIPYGDWFEM----VSCPHYLAEIVIYAGllIASGGTDLTIWLLFGF 288

                         90       100       110
                 ....*....|....*....|....*....|....
gi 24475816  274 GFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFL 307
Cdd:PLN03164 289 VVANLTFAAAETHRWYLQKFENYPRNRYAIIPFV 322
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
 22-77 7.08e-04

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 37.58  E-value: 7.08e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24475816  22 KVEPHATIAEIKNLFTKTHpQWYPARQSLRLdpKGKSLKDEDVLQKLPVGTTATLY 77
Cdd:cd17039  14 EVDPDDTVADLKEKIEEKT-GIPVEQQRLIY--NGKELKDDKTLSDYGIKDGSTIH 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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