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Conserved domains on  [gi|21070980|ref|NP_620176|]
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peptidyl-glycine alpha-amidating monooxygenase isoform c precursor [Homo sapiens]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 393-700 2.36e-149

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 441.32  E-value: 2.36e-149
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 393 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 472
Cdd:cd14958   1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 473 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 552
Cdd:cd14958  77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 553 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 631
Cdd:cd14958 156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21070980 632 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14958 229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.78e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.79  E-value: 1.78e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 3.61e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 104.26  E-value: 3.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980    59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21070980   132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 393-700 2.36e-149

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 441.32  E-value: 2.36e-149
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 393 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 472
Cdd:cd14958   1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 473 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 552
Cdd:cd14958  77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 553 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 631
Cdd:cd14958 156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21070980 632 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14958 229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.78e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.79  E-value: 1.78e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 3.61e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 104.26  E-value: 3.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980    59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21070980   132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
450-706 5.37e-16

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 78.91  E-value: 5.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 450 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPV-LILGrsmqPGSDQNhfcqPTD 528
Cdd:COG4257  38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 529 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGKFitqwgeeSSGSSPLPGQFtvPHSLALVPlLGQLCVADRENGRIQCFKTD 607
Cdd:COG4257 107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 608 TKEFVREIKHSSFGRNVfaisyipGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFdmPHDIVASEDGTVY 687
Cdd:COG4257 175 TGTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVW 245

                       250
                ....*....|....*....
gi 21070980 688 IGDAHTNTVWKFTLTEKLE 706
Cdd:COG4257 246 FAESGANRIVRFDPDTELT 264
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 536-700 6.50e-05

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 45.78  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   536 GAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREI 615
Cdd:pfam17170  54 DRIFVFDSN-TNNLFVFDKKGKFVRQIGAQGNG----PGEYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGYSFIGEI 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   616 KHSSFgrNVFAISYIPG-LLFAVNGKPHfGDQEPVQgFVMNFSNGEIIDIFKPVRKHFDM---PHDIVASEDGTVYIGDA 691
Cdd:pfam17170 129 NLDLL--PSDCCQLDKGkLAFDSSGFDD-GKRSGFY-LVITDELGNIISGFFPAEFTLGIlfnSSVPFYEYGDNIYFYPY 204


                  ....*....
gi 21070980   692 HTNTVWKFT 700
Cdd:pfam17170 205 YSPTVYKIM 213
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 393-700 2.36e-149

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 441.32  E-value: 2.36e-149
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 393 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 472
Cdd:cd14958   1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 473 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 552
Cdd:cd14958  77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 553 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 631
Cdd:cd14958 156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21070980 632 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14958 229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.78e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.79  E-value: 1.78e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 408-699 1.15e-44

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 162.10  E-value: 1.15e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 408 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPNNAAVLQ--SSGKNL--FYLPHGLSIDKDG 483
Cdd:cd05819  11 QGIAVDSSGNIYVADTGNN------------------------RIQVFDPDGNFITSfgSFGSGDgqFNEPAGVAVDSDG 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 484 NYWVTDVALHQVFKLDPNNKEgpVLILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWG 563
Cdd:cd05819  67 NLYVADTGNHRIQKFDPDGNF--LASFGGS---GDGDGEFNGPRGIAVDS-SGNIYVAD-TGNHRIQKFDPDGEFLTTFG 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 564 EESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTkEFVREIKHSSFGRNVFaiSYIPGLLFAVNGKPHF 643
Cdd:cd05819 140 SGGSG----PGQFNGPTGVAVDS-DGNIYVADTGNHRIQVFDPDG-NFLTTFGSTGTGPGQF--NYPTGIAVDSDGNIYV 211

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21070980 644 GDQEPVQGFVMNFSNGEIIDI--FKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKF 699
Cdd:cd05819 212 ADSGNNRVQVFDPDGAGFGGNgnFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 466-700 2.62e-28

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 115.37  E-value: 2.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 466 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 545
Cdd:cd14955 104 SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSG--TFITKWGSF---GSGDGQFNSPTGIAVD-SAGNVYVADTG- 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 546 NSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTDTkEFVreikhSSFGrnvf 625
Cdd:cd14955 177 NNRIQKFTSTGTFLTKWGSEGSG----DGQFNAPYGIA-VDSAGNVYVADTGNNRIQKFDSSG-TFI-----TKWG---- 241

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21070980 626 aiSYIPGllfavngkphfgdqepvqgfvmnfsNGEiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14955 242 --SEGSG-------------------------DGQ-----------FNSPSGIAVDSAGNVYVADSGNNRIQKFA 278
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 471-607 1.27e-27

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 113.15  E-value: 1.27e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 471 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIV 550
Cdd:cd14956 106 FNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNYPRGVAVDPD-GTLYVADTY-NDRIQ 178

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21070980 551 QFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTD 607
Cdd:cd14956 179 VFDNDGAFLRKWGGRGTG----PGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFTAD 230
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 3.61e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 104.26  E-value: 3.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980    59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 21070980   132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 450-699 2.35e-25

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 106.60  E-value: 2.35e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 450 DTILVIDPNNAAVL--------------QSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGRsmq 515
Cdd:cd14956  24 DNVYVADARNGRIQvfdkdgtflrrfgtTGDGPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGE--LQTIGGS--- 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 516 PGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVAD 595
Cdd:cd14956  99 SGSGPGQFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSFLRQWGGTGIE----PGSFNYPRGVAVDP-DGTLYVAD 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 596 RENGRIQCFKTDTKeFVREI-KHSSFG---RNVFAISYIP-GLLFAVNgkphFGDQEpVQGFVMnfsNGEIIDIF--KPV 668
Cdd:cd14956 172 TYNDRIQVFDNDGA-FLRKWgGRGTGPgqfNYPYGIAIDPdGNVFVAD----FGNNR-IQKFTA---DGTFLTSWgsPGT 242

                       250       260       270
                ....*....|....*....|....*....|..
gi 21070980 669 RKH-FDMPHDIVASEDGTVYIGDAHTNTVWKF 699
Cdd:cd14956 243 GPGqFKNPWGVVVDADGTVYVADSNNNRVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 466-702 6.12e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 99.57  E-value: 6.12e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 466 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVLILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 545
Cdd:cd14955  10 SGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDST---GTFLTKWGS--SGSGDGQFYSPTGIAVD-SDGNVYVADTG- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 546 NSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLAlVPLLGQLCVADRENGRIQcfktdtkefvreiKHSSFGrnvf 625
Cdd:cd14955  83 NHRIQKFDSTGTFLTKWGSSGSGD----GQFNSPSGIA-VDSAGNVYVTDSGNNRIQ-------------KFDSSG---- 140

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21070980 626 aisyipgllfavngkphfgdqepvqGFVMNFSNGEIIDifkpvrKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 702
Cdd:cd14955 141 -------------------------TFITKWGSFGSGD------GQFNSPTGIAVDSAGNVYVADTGNNRIQKFTST 186
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 406-604 3.84e-22

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 97.26  E-value: 3.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 406 QVSGVALDPKNNLvifhrgdHVWD-GNS----FDSKFVY------------QQIGLGPIEEDT---ILVIDPNNAAV--L 463
Cdd:cd14955  64 SPTGIAVDSDGNV-------YVADtGNHriqkFDSTGTFltkwgssgsgdgQFNSPSGIAVDSagnVYVTDSGNNRIqkF 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 464 QSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRsmqPGSDQNHFCQPTDVAV 531
Cdd:cd14955 137 DSSGTFItkwgsfgsgdgqFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAV 211

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21070980 532 DpGTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 604
Cdd:cd14955 212 D-SAGNVYVADTG-NNRIQKFDSSGTFITKWGSEGSG----DGQFNSPSGIA-VDSAGNVYVADSGNNRIQKF 277
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 467-622 1.27e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 89.57  E-value: 1.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 467 GKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGRSMQpgsdqnhFCQPTDVAVDPGTGAIYVSDGYcN 546
Cdd:cd14962  52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGK--FLRAIGAGAL-------FKRPTGIAVDPAGKRLYVVDTL-A 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21070980 547 SRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVReikhsSFGR 622
Cdd:cd14962 122 HKVKVFDLDGRLLFDIGKRGSG----PGEFNLPTDLAVDR-DGNLYVTDTMNFRVQIFDADGK-FLR-----SFGE 186
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 447-690 5.55e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 87.73  E-value: 5.55e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 447 IEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVA--LHQVFkldpnNKEGPVLil 510
Cdd:cd14963  17 VSDGRIYVADTNNhrVQVFDYEGKFKksfggpgtgpgeFKYPYGIAVDSDGNIYVADLYngRIQVF-----DPDGKFL-- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 511 gRSMQPGSDQNHFCQPTDVAVDPGTgaIYVSD-GYcnSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLG 589
Cdd:cd14963  90 -KYFPEKKDRVKLISPAGLAIDDGK--LYVSDvKK--HKVIVFDLEGKLLLEFGKPGSE----PGELSYPNGIAVDE-DG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 590 QLCVADRENGRIQCFKTDTKeFVREIKHSSFGRNVFA----ISYIP-GLLFAVNGKPHFgdqepVQGFVMNFSNGEIIDI 664
Cdd:cd14963 160 NIYVADSGNGRIQVFDKNGK-FIKELNGSPDGKSGFVnprgIAVDPdGNLYVVDNLSHR-----VYVFDEQGKELFTFGG 233

                       250       260
                ....*....|....*....|....*.
gi 21070980 665 FKPVRKHFDMPHDIVASEDGTVYIGD 690
Cdd:cd14963 234 RGKDDGQFNLPNGLFIDDDGRLYVTD 259
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 404-604 1.23e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 86.95  E-value: 1.23e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 404 PGQ---VSGVALDPKNNLVIfhrgdhvwdgnsfdSKFVYQQIglgpieedtiLVIDPNNAAVLQ----SSGKNLFYLPHG 476
Cdd:cd14956 103 PGQfnaPRGVAVDADGNLYV--------------ADFGNQRI----------QKFDPDGSFLRQwggtGIEPGSFNYPRG 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 477 LSIDKDGNYWVTDVALH--QVFkldpNNKEGPVLILGrsmQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSP 554
Cdd:cd14956 159 VAVDPDGTLYVADTYNDriQVF----DNDGAFLRKWG---GRGTGPGQFNYPYGIAIDP-DGNVFVADFG-NNRIQKFTA 229

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 21070980 555 SGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCF 604
Cdd:cd14956 230 DGTFLTSWGSPGTG----PGQFKNPWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 384-604 2.91e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 86.06  E-value: 2.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 384 VLDQDFHMEEALDWPGVYLL--------PGQVS---GVALDPKNNLVIFHRGDH---VWDGN-SFDSKFVYQQIGLGPIE 448
Cdd:cd14954  86 VADKDNHRIQVFDLNGRFLLkfgergtkNGQFNypwGVAVDSEGRIYVSDTRNHrvqVFDSDgQFIRKFGFEGAGPGQLD 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 449 EdtilvidpnnaavlqssgknlfylPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGrsmQPGSDQNHFCQPTD 528
Cdd:cd14954 166 S------------------------PRGVAVNPDGNIVVSDFNNHRLQVFDPDGQ--FLRFFG---SEGSGNGQFKRPRG 216

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21070980 529 VAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCF 604
Cdd:cd14954 217 VAVDDE-GNIIVADSG-NHRVQVFSPDGEFLCSFGTEGNG----EGQFDRPSGVAVTP-DGRIVVVDRGNHRIQVF 285
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 471-702 3.06e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 85.80  E-value: 3.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 471 FYLPHGLSIDKDGNYWVTDVALH--QVFKLDPNNKegpvlilGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDgYCNSR 548
Cdd:cd14956  12 FKDPRGIAVDADDNVYVADARNGriQVFDKDGTFL-------RRFGTTGDGPGQFGRPRGLAVDKD-GWLYVAD-YWGDR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 549 IVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTDTKeFVREIkhssfgrnvfais 628
Cdd:cd14956  83 IQVFTLTGELQTIGGSSGSG----PGQFNAPRGVA-VDADGNLYVADFGNQRIQKFDPDGS-FLRQW------------- 143

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21070980 629 yipgllfavnGKPhfgDQEPVQgfvmnfsngeiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 702
Cdd:cd14956 144 ----------GGT---GIEPGS---------------------FNYPRGVAVDPDGTLYVADTYNDRIQVFDND 183
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 465-700 1.43e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 83.85  E-value: 1.43e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 465 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSD 542
Cdd:cd14957  11 GSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVF-----TSSGVYSYSIGS--GGTGSGQFNSPYGIAVD-SNGNIYVAD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 543 gYCNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFkTDTKEFVREIKHSSFGR 622
Cdd:cd14957  83 -TDNNRIQVFNSSGVYQYSIG--TGGSG--DGQFNGPYGIA-VDSNGNIYVADTGNHRIQVF-TSSGTFSYSIGSGGTGP 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 623 NVFaiSYIPGLLFAVNGKPHFGDQepvqgfvMN-----FSN-GEIIDIF---KPVRKHFDMPHDIVASEDGTVYIGDAHT 693
Cdd:cd14957 156 GQF--NGPQGIAVDSDGNIYVADT-------GNhriqvFTSsGTFQYTFgssGSGPGQFSDPYGIAVDSDGNIYVADTGN 226


                ....*..
gi 21070980 694 NTVWKFT 700
Cdd:cd14957 227 HRIQVFT 233
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 465-604 7.50e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 81.93  E-value: 7.50e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 465 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPVLILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSD 542
Cdd:cd14957 152 GTGPGQFNGPQGIAVDSDGNIYVADTGNHriQVF----TSSGTFQYTFG---SSGSGPGQFSDPYGIAVD-SDGNIYVAD 223

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21070980 543 gYCNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 604
Cdd:cd14957 224 -TGNHRIQVFTSSGAYQYSIG--TSGSG--NGQFNYPYGIA-VDNDGKIYVADSNNNRIQVF 279
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 517-704 4.76e-16

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 79.26  E-value: 4.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 517 GSDQNHFCQPTDVAVDPGTgaIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADR 596
Cdd:cd14963   3 GPFGDPLNKPMGVAVSDGR--IYVADTN-NHRVQVFDYEGKFKKSFGGPGTG----PGEFKYPYGIAVDSD-GNIYVADL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 597 ENGRIQCFKTDTKeFVREIKHSSFGRNVFAisyiPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK--HFDM 674
Cdd:cd14963  75 YNGRIQVFDPDGK-FLKYFPEKKDRVKLIS----PAGLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEpgELSY 149

                       170       180       190
                ....*....|....*....|....*....|
gi 21070980 675 PHDIVASEDGTVYIGDAHTNTVWKFTLTEK 704
Cdd:cd14963 150 PNGIAVDEDGNIYVADSGNGRIQVFDKNGK 179
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
450-706 5.37e-16

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 78.91  E-value: 5.37e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 450 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPV-LILGrsmqPGSDQNhfcqPTD 528
Cdd:COG4257  38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 529 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGKFitqwgeeSSGSSPLPGQFtvPHSLALVPlLGQLCVADRENGRIQCFKTD 607
Cdd:COG4257 107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 608 TKEFVREIKHSSFGRNVfaisyipGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFdmPHDIVASEDGTVY 687
Cdd:COG4257 175 TGTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVW 245

                       250
                ....*....|....*....
gi 21070980 688 IGDAHTNTVWKFTLTEKLE 706
Cdd:COG4257 246 FAESGANRIVRFDPDTELT 264
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 465-696 6.95e-15

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 75.77  E-value: 6.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 465 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVL-ILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVS 541
Cdd:cd14957  58 GTGSGQFNSPYGIAVDSNGNIYVADTDNNriQVF-----NSSGVYQySIGTG---GSGDGQFNGPYGIAVDS-NGNIYVA 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 542 DGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADRENGRIQCFkTDTKEFVREIKHSSFG 621
Cdd:cd14957 129 DTG-NHRIQVFTSSGTFSYSIGSGGTG----PGQFNGPQGIAVDSD-GNIYVADTGNHRIQVF-TSSGTFQYTFGSSGSG 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 622 rnvfaisyiPGLLF-----AV--NGKPHFGDQ--EPVQ------GFVMNFSNGEIIDifkpvrKHFDMPHDIVASEDGTV 686
Cdd:cd14957 202 ---------PGQFSdpygiAVdsDGNIYVADTgnHRIQvftssgAYQYSIGTSGSGN------GQFNYPYGIAVDNDGKI 266

                       250
                ....*....|
gi 21070980 687 YIGDAHTNTV 696
Cdd:cd14957 267 YVADSNNNRI 276
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 443-696 2.34e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 74.51  E-value: 2.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 443 GLGPIEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkegpvl 508
Cdd:cd14954  28 GVAVDKDGRIIVADRSNnrVQVFDPDGKFLrkfgsygsrdgqFDRPAGVAVNSRGRIIVADKDNHRIQVFDLN------- 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 509 ilGRSM----QPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESsgssPLPGQFTVPHSLAL 584
Cdd:cd14954 101 --GRFLlkfgERGTKNGQFNYPWGVAVDSE-GRIYVSDTR-NHRVQVFDSDGQFIRKFGFEG----AGPGQLDSPRGVAV 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 585 VPLlGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRNVFAISYipGLLFAVNGKPHFGDQ--EPVQGFVmnfSNGEII 662
Cdd:cd14954 173 NPD-GNIVVSDFNNHRLQVFDPDGQ-FLRFFGSEGSGNGQFKRPR--GVAVDDEGNIIVADSgnHRVQVFS---PDGEFL 245

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 21070980 663 DIF---KPVRKHFDMPHDIVASEDGTVYIGDAHTNTV 696
Cdd:cd14954 246 CSFgteGNGEGQFDRPSGVAVTPDGRIVVVDRGNHRI 282
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
474-699 7.89e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 72.74  E-value: 7.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 474 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRsmqpgsdqnhFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFS 553
Cdd:COG4257  19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG----------GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 554 PSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKEfVREIKHSSFGRNVFAISYIPG- 632
Cdd:COG4257  87 PKTGEITTF--------ALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPYGIAVDPDg 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21070980 633 -LLFAVNGKPHFGdqepvqgfVMNFSNGEiIDIFKPVRKhFDMPHDIVASEDGTVYIGDAHTNTVWKF 699
Cdd:COG4257 157 nLWVTDFGANAIG--------RIDPDTGT-LTEYALPTP-GAGPRGLAVDPDGNLWVADTGSGRIGRF 214
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 471-613 1.26e-13

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 72.20  E-value: 1.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 471 FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGP-VLILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYcNS 547
Cdd:cd14954  23 LCRPWGVAVDKDGRIIVADRSNNrvQVF-----DPDGKfLRKFGSY---GSRDGQFDRPAGVAVN-SRGRIIVADKD-NH 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21070980 548 RIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTDTKeFVR 613
Cdd:cd14954  93 RIQVFDLNGRFLLKFGERGTK----NGQFNYPWGVA-VDSEGRIYVSDTRNHRVQVFDSDGQ-FIR 152
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 408-601 1.85e-13

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 72.18  E-value: 1.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 408 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPN-------------------NAAvlqssgk 468
Cdd:cd14953  26 SGVAVDAAGNLYVADRGNH------------------------RIRKITPDgvvttvagtgtagfadgggAAA------- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 469 nLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVL------ILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSD 542
Cdd:cd14953  75 -QFNTPSGVAVDAAGNLYVADTGNHRIRKITPD---GVVStlagtgTAGFSDDGGATAAQFNYPTGVAVDA-AGNLYVAD 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21070980 543 GYcNSRIVQFSPSGKFITQWGEESSGSSPL-PG---QFTVPHSLAlVPLLGQLCVADRENGRI 601
Cdd:cd14953 150 TG-NHRIRKITPDGVVTTVAGTGGAGYAGDgPAtaaQFNNPTGVA-VDAAGNLYVADRGNHRI 210
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
394-608 2.05e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 70.88  E-value: 2.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 394 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 471
Cdd:COG3391  38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 472 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 548
Cdd:COG3391 112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21070980 549 IVQ-FSP-SGKFITQWgeessgssPLPGQftvPHSLALVPLLGQLCVADRENG-------RIQCFKTDT 608
Cdd:COG3391 179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSNtsnggsnTVSVIDLAT 236
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 452-604 6.39e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 69.92  E-value: 6.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 452 ILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSDQNHFCQPTDVA 530
Cdd:cd14962  80 VFVFDRDGKFLRAIGAGALFKRPTGIAVDPAGKRlYVVDTLAHKVKVFDLDGRL-----LFDIGKRGSGPGEFNLPTDLA 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 531 VDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWGE-------------------------ESS------------------ 567
Cdd:cd14962 155 VDR-DGNLYVTDTM-NFRVQIFDADGKFLRSFGErgdgpgsfarpkgiavdsegniyvvDAAfdnvqifnpegellltvg 232

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21070980 568 GSSPLPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 604
Cdd:cd14962 233 GPGSGPGEFYLPSGIA-IDKDDRIYVVDQFNRRIQVF 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 396-608 8.02e-13

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 69.61  E-value: 8.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 396 DWPGVYLLPgqvSGVALDPKNNLVIFHrgdhvwDGNS----FDSK-FVYQQIGlgPIEEDTILVIDPNNAAV-------- 462
Cdd:cd14961   5 GWPGTLNNP---TGVAVTPTGRVVVAD------DGNKriqvFDSDgNCLQQFG--PKGDAGQDIRYPLDVAVtpdghivv 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 463 ----------------LQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSmqpgsdQNHFCQP 526
Cdd:cd14961  74 tdagdrsvkvfsfdgrLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGILKKGQKL------CSQLCRP 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 527 TDVAVDPgTGAIYVSD-------GYCNSRIVQFSPSGKFITQWGeeSSGSSPLPGQFTVPHSLAlVPLLGQLCVADRENG 599
Cdd:cd14961 148 RFVAVSR-LGAVAVTEhlfangtRSSSTRVKVFSSGGQLLGQID--SFGLNLVFPSLICASGVA-FDSEGNVIVADTGSG 223


                ....*....
gi 21070980 600 RIQCFKTDT 608
Cdd:cd14961 224 AILCLGKPE 232
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 516-700 2.21e-12

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 68.45  E-value: 2.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 516 PGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVAD 595
Cdd:cd14957  10 NGSGNGQFNTPRGIAVDSA-GNIYVADTG-NNRIQVFTSSGVYSYSIG--SGGTG--SGQFNSPYGIA-VDSNGNIYVAD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 596 RENGRIQCFkTDTKEFVREIKHSSFGRNVFaiSYIPGLLFAVNGKPHFGDQ--EPVQGFVMNFSNGEIIDIFKPVRKHFD 673
Cdd:cd14957  83 TDNNRIQVF-NSSGVYQYSIGTGGSGDGQF--NGPYGIAVDSNGNIYVADTgnHRIQVFTSSGTFSYSIGSGGTGPGQFN 159

                       170       180
                ....*....|....*....|....*..
gi 21070980 674 MPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14957 160 GPQGIAVDSDGNIYVADTGNHRIQVFT 186
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 462-604 3.94e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 67.32  E-value: 3.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 462 VLQSSGKNLFYLPH-----------GLSIDkDGNYWVTDVALHQVFKLDPNNKEgpVLILGRsmqPGSDQNHFCQPTDVA 530
Cdd:cd14963  81 VFDPDGKFLKYFPEkkdrvklispaGLAID-DGKLYVSDVKKHKVIVFDLEGKL--LLEFGK---PGSEPGELSYPNGIA 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 531 VDPgTGAIYVSD-GycNSRIVQFSPSGKFITQWGEESSGSSPL------------------------------------- 572
Cdd:cd14963 155 VDE-DGNIYVADsG--NGRIQVFDKNGKFIKELNGSPDGKSGFvnprgiavdpdgnlyvvdnlshrvyvfdeqgkelftf 231

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 21070980 573 ------PGQFTVPHSLALVPLlGQLCVADRENGRIQCF 604
Cdd:cd14963 232 ggrgkdDGQFNLPNGLFIDDD-GRLYVTDRENNRVAVY 268
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 452-605 5.84e-12

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 66.98  E-value: 5.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 452 ILVIDPNNAAVL--QSSGKNLFYL-------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNH 522
Cdd:cd14960  77 IIIADYDNKWVSifSPDGKFKSKIgagklmgPKGVAVDRNGHIIVVDNKACCVFIFQPNGK-----LVTRFGSRGNGDRQ 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 523 FCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADRENGRIQ 602
Cdd:cd14960 152 FAGPHFAAVNN-NNEIIVTD-FHNHSVKVFNAEGEFLFKFGSNGEG----NGQFNAPTGVAVDSN-GNIIVADWGNSRIQ 224


                ...
gi 21070980 603 CFK 605
Cdd:cd14960 225 VFD 227
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 408-601 5.69e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 64.86  E-value: 5.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 408 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPN--------NAAVLQSSGKN----LFYLPH 475
Cdd:cd14953 135 TGVAVDAAGNLYVADTGNHR------------------------IRKITPDgvvttvagTGGAGYAGDGPataaQFNNPT 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 476 GLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVL-ILGRSMQPGSDQNH-----FCQPTDVAVDpGTGAIYVSDgYCNSRI 549
Cdd:cd14953 191 GVAVDAAGNLYVADRGNHRIRKITPD---GVVTtVAGTGTAGFSGDGGataaqLNNPTGVAVD-AAGNLYVAD-SGNHRI 265

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21070980 550 VQFSPSGKFIT----QWGEESSGSSPLPGQFTVPHSLALVPlLGQLCVADRENGRI 601
Cdd:cd14953 266 RKITPAGVVTTvaggGAGFSGDGGPATSAQFNNPTGVAVDA-AGNLYVADTGNNRI 320
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 501-604 1.94e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 62.57  E-value: 1.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 501 NNKEGPVLILGRSmqpGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPH 580
Cdd:cd14954   4 RAKGRPLLSFGKE---GSKDGELCRPWGVAVDKD-GRIIVADRS-NNRVQVFDPDGKFLRKFGSYGSR----DGQFDRPA 74

                        90       100
                ....*....|....*....|....
gi 21070980 581 SLAlVPLLGQLCVADRENGRIQCF 604
Cdd:cd14954  75 GVA-VNSRGRIIVADKDNHRIQVF 97
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 474-601 4.62e-10

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 61.07  E-value: 4.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 474 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLilgrsmqPGSDQNhfcQPTDVAVDpGTGAIYVSDGYcNSRIVQFS 553
Cdd:cd14952  12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVL-------PFTGLY---QPQGVAVD-AAGTVYVTDFG-NNRVLKLA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 21070980 554 PSgkfitqwgeeSSGSSPLPgqFT---VPHSLAlVPLLGQLCVADRENGRI 601
Cdd:cd14952  80 AG----------STTQTVLP--FTglnDPTGVA-VDAAGNVYVADTGNNRV 117
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 471-700 5.54e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 61.78  E-value: 5.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 471 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVLILGRSMQPGSD-----QNHFCQPTDVAVDPGtGAIYVSDGYc 545
Cdd:cd14953  22 FNSPSGVAVDAAGNLYVADRGNHRIRKITPD---GVVTTVAGTGTAGFAdgggaAAQFNTPSGVAVDAA-GNLYVADTG- 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 546 NSRIVQFSPSGKFITQWGEESSGSSPLPG----QFTVPHSLAlVPLLGQLCVADRENGRIQcfKTDTKEFVReikhssfg 621
Cdd:cd14953  97 NHRIRKITPDGVVSTLAGTGTAGFSDDGGataaQFNYPTGVA-VDAAGNLYVADTGNHRIR--KITPDGVVT-------- 165

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21070980 622 rnVFAISYIPGllFAVNGkphfgdqepvqgfvmnfsNGeiidifkpVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14953 166 --TVAGTGGAG--YAGDG------------------PA--------TAAQFNNPTGVAVDAAGNLYVADRGNHRIRKIT 214
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 474-714 5.60e-10

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 61.06  E-value: 5.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 474 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEgpVLILGRSmqpgsDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFS 553
Cdd:cd14962  14 PYGVAADGRGRIYVADTGRGAVFVFDLPNGK--VFVIGNA-----GPNRFVSPIGVAIDAN-GNLYVSDAE-LGKVFVFD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 554 PSGKFITQWGEessgssplPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEfvreikhssfgrnVFAIsyipgl 633
Cdd:cd14962  85 RDGKFLRAIGA--------GALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL-------------LFDI------ 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 634 lfavnGKPHFGDQEpvqgfvmnfsngeiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLeHRSVKKA 713
Cdd:cd14962 138 -----GKRGSGPGE------------------------FNLPTDLAVDRDGNLYVTDTMNFRVQIFDADGKF-LRSFGER 187


                .
gi 21070980 714 G 714
Cdd:cd14962 188 G 188
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 517-690 1.54e-08

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 56.89  E-value: 1.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 517 GSDQNHFCQPTDVAVDpGTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLALVPLLGQLCVADR 596
Cdd:cd14959  15 GSGEGQFNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPGKRD----GQLWYPNKVAVCRVTGRYVVTDR 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 597 ENG--RIQCFkTDTKEFVREikhssfgrnvFAISYI--PGLLfAVNGKPHFGDQEPVQGFVMNFS-NGEIIDIFKpVRKH 671
Cdd:cd14959  89 GNPrhRMQIF-TKRGQFVRK----------FGARYLqhVRGL-TVDAAGHIIVVESKVMRVFIFDeSGNVLKWFD-CSKY 155

                       170
                ....*....|....*....
gi 21070980 672 FDMPHDIVASeDGTVYIGD 690
Cdd:cd14959 156 LEEPSDVAVN-DNEIYICD 173
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 404-550 1.69e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 56.53  E-value: 1.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 404 PGQVS---GVALDPKNNLvifhrgdHVWDGNSfdskfvyqqiglgpieeDTILVIDPNNAAVLQSSGK----NLFYLPHG 476
Cdd:cd14963 144 PGELSypnGIAVDEDGNI-------YVADSGN-----------------GRIQVFDKNGKFIKELNGSpdgkSGFVNPRG 199

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21070980 477 LSIDKDGNYWVTDVALHQVFKLDPNNKEgpVLILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSDgYCNSRIV 550
Cdd:cd14963 200 IAVDPDGNLYVVDNLSHRVYVFDEQGKE--LFTFG---GRGKDDGQFNLPNGLFID-DDGRLYVTD-RENNRVA 266
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 474-551 8.81e-08

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 54.14  E-value: 8.81e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21070980 474 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLilgrsmqPGSDQNHfcqPTDVAVDPgTGAIYVSDgYCNSRIVQ 551
Cdd:cd14952 180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTVL-------PFTGLNG---PLGVAVDA-AGNVYVAD-RGNDRVVK 245
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
538-696 3.91e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.00  E-value: 3.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 538 IYVSDGYcNSRIVQFSP-SGKFITQWgeeSSGSSPlpgqftvpHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIK 616
Cdd:COG3391  82 LYVANSG-SGRVSVIDLaTGKVVATI---PVGGGP--------RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIP 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 617 hssFGRNVFAISYIP--GLLFAVNgkphFGDQEpVQGFV--MNFSNGEIIDIFKPvrkhFDMPHDIVASEDG-TVYIGDA 691
Cdd:COG3391 150 ---VGAGPHGIAVDPdgKRLYVAN----SGSNT-VSVIVsvIDTATGKVVATIPV----GGGPVGVAVSPDGrRLYVANR 217


                ....*
gi 21070980 692 HTNTV 696
Cdd:COG3391 218 GSNTS 222
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 474-601 4.05e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.21  E-value: 4.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 474 PHGLSIDKDGNYWVTDVALHQVFKLDPnnkegpvlilGRSMQ---PGSDQNHfcqPTDVAVDPGtGAIYVSDGYcNSRIV 550
Cdd:cd14952  96 PTGVAVDAAGNVYVADTGNNRVLKLAA----------GSNTQtvlPFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVL 160

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21070980 551 QFsPSGkfitqwgeeSSGSSPLPgqFT---VPHSLAlVPLLGQLCVADRENGRI 601
Cdd:cd14952 161 KL-AAG---------STTQTVLP--FTglnSPSGVA-VDTAGNVYVTDHGNNRV 201
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 466-559 9.54e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 51.12  E-value: 9.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 466 SGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLilgrsMQ---PGSDQNHFCQPTDVAVDPGTGAIYV 540
Cdd:cd14959  16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVF-----DKEGEFK-----FQfgiPGKRDGQLWYPNKVAVCRVTGRYVV 85

                        90       100
                ....*....|....*....|
gi 21070980 541 SD-GYCNSRIVQFSPSGKFI 559
Cdd:cd14959  86 TDrGNPRHRMQIFTKRGQFV 105
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 464-553 3.34e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 49.57  E-value: 3.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 464 QSSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLilgRSM-QPGSDQNHFCQPTDVAVDpGTGAIYV 540
Cdd:cd14957 198 SGSGPGQFSDPYGIAVDSDGNIYVADTGNHriQVF-----TSSGAYQ---YSIgTSGSGNGQFNYPYGIAVD-NDGKIYV 268

                        90
                ....*....|...
gi 21070980 541 SDGYcNSRIVQFS 553
Cdd:cd14957 269 ADSN-NNRIQVFN 280
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
528-699 3.41e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 3.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 528 DVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQ-LCVADRENGRIQCFKT 606
Cdd:COG3391  18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 607 DTKEFVREIKHSSFGRNVfAISYIPGLLFAVNGKPHFgdqepVQgfVMNFSNGEIIDIFKPvrkhFDMPHDIVASEDG-T 685
Cdd:COG3391  98 ATGKVVATIPVGGGPRGL-AVDPDGGRLYVADSGNGR-----VS--VIDTATGKVVATIPV----GAGPHGIAVDPDGkR 165

                       170
                ....*....|....
gi 21070980 686 VYIGDAHTNTVWKF 699
Cdd:COG3391 166 LYVANSGSNTVSVI 179
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 517-690 4.66e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 49.20  E-value: 4.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 517 GSDQNHFCQPTDVAVDPgTGAIYVSD-GycNSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLALVPlLGQLCVAD 595
Cdd:cd14961   4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGPKGDAG----QDIRYPLDVAVTP-DGHIVVTD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 596 RENGRIqcfktdtKEFVREIKHSSFGRNVFAISYipGLlfAVNGKPHF--GDQEpvQG----FVMNFSNGEIIDIFKpVR 669
Cdd:cd14961  76 AGDRSV-------KVFSFDGRLKLFVRKSFSLPW--GV--AVNPSGEIlvTDSE--AGklfvLTVDFKLGILKKGQK-LC 141

                       170       180
                ....*....|....*....|.
gi 21070980 670 KHFDMPHDIVASEDGTVYIGD 690
Cdd:cd14961 142 SQLCRPRFVAVSRLGAVAVTE 162
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 452-605 6.77e-06

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 48.50  E-value: 6.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 452 ILVIDPNNAAVL--QSSGK------------NLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLILGRSMQ 515
Cdd:cd14960 119 IIVVDNKACCVFifQPNGKlvtrfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHsvKVF-----NAEGEFLFKFGSNG 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 516 PGSDQnhFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWGeesSGSSPLPGqftvPHSLALVPlLGQLCVAD 595
Cdd:cd14960 194 EGNGQ--FNAPTGVAVDS-NGNIIVAD-WGNSRIQVFDSSGSFLSYIN---TSADPLYG----PQGLALTS-DGHVVVAD 261

                       170
                ....*....|
gi 21070980 596 RENgriQCFK 605
Cdd:cd14960 262 SGN---HCFK 268
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 447-607 2.21e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 47.19  E-value: 2.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 447 IEEDTILVIDPNNAAV---LQSSGknlfyLPHGLSIDKDGNYWVTDvALHQVFKLDPNNKEgPVLILGRSMQPGSdqnhf 523
Cdd:COG3386  26 IPGGRIHRYDPDGGAVevfAEPSG-----RPNGLAFDPDGRLLVAD-HGRGLVRFDPADGE-VTVLADEYGKPLN----- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 524 cQPTDVAVDPGtGAIYVSD---GYCNSRIVQFSPSGKFitqwgeessgsSPLPGQFTVPHSLALVPLLGQLCVADRENGR 600
Cdd:COG3386  94 -RPNDGVVDPD-GRLYFTDmgeYLPTGALYRVDPDGSL-----------RVLADGLTFPNGIAFSPDGRTLYVADTGAGR 160


                ....*..
gi 21070980 601 IQCFKTD 607
Cdd:COG3386 161 IYRFDLD 167
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 558-700 2.63e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 46.80  E-value: 2.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 558 FITQWGEESSGSsplpGQFTVPHSLAlVPLLGQLCVADRENGRIQCFkTDTKEFVreIKHSSFGrnvfaisyipgllfav 637
Cdd:cd14955   1 FVTQWGSYGSGD----GQFNSPSGIA-VDSAGNVYVADTGNNRIQKF-DSTGTFL--TKWGSSG---------------- 56

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21070980 638 ngkphfgdqepvqgfvmnFSNGEiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 700
Cdd:cd14955  57 ------------------SGDGQ-----------FYSPTGIAVDSDGNVYVADTGNHRIQKFD 90
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 536-700 6.50e-05

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 45.78  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   536 GAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREI 615
Cdd:pfam17170  54 DRIFVFDSN-TNNLFVFDKKGKFVRQIGAQGNG----PGEYLQINDFIIDKSNNSIYILDFMQNKILTYDLDGYSFIGEI 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980   616 KHSSFgrNVFAISYIPG-LLFAVNGKPHfGDQEPVQgFVMNFSNGEIIDIFKPVRKHFDM---PHDIVASEDGTVYIGDA 691
Cdd:pfam17170 129 NLDLL--PSDCCQLDKGkLAFDSSGFDD-GKRSGFY-LVITDELGNIISGFFPAEFTLGIlfnSSVPFYEYGDNIYFYPY 204


                  ....*....
gi 21070980   692 HTNTVWKFT 700
Cdd:pfam17170 205 YSPTVYKIM 213
MALA cd12811
Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia ...
 526-631 8.74e-05

Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.


Pssm-ID: 411995 [Multi-domain]  Cd Length: 304  Bit Score: 45.32  E-value: 8.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21070980 526 PTDVAVDPgTGAIYVSDGYCNSrIVQFSPSGKFITQWGEESSGSSPLPGqFTvphSLALVPLLGQLCVADRENGRIQCFK 605
Cdd:cd12811 123 FQDSAQDS-DGNSYVVGALPPA-IAKVSPDGKTVTPWFLEAPNGSTRPG-YT---GIAYIPEDNVLLASGGEPGQLTRFD 196

                        90       100       110
                ....*....|....*....|....*....|
gi 21070980 606 TD----TKEFVReIKHSSFGRNVFAIsYIP 631
Cdd:cd12811 197 LSsatpTPIPVK-ISGENFGGLDDGE-KLP 224
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 576-604 5.74e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|....*....
gi 21070980   576 FTVPHSLALVPLlGQLCVADRENGRIQCF 604
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVADSENHRVQVF 28
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 523-552 2.71e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.84  E-value: 2.71e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 21070980   523 FCQPTDVAVDPGtGAIYVSDgYCNSRIVQF 552
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVAD-SENHRVQVF 28
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 672-699 3.98e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 3.98e-03
                          10        20
                  ....*....|....*....|....*...
gi 21070980   672 FDMPHDIVASEDGTVYIGDAHTNTVWKF 699
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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