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Conserved domains on  [gi|46371195|ref|NP_694989|]
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zinc finger protein 461 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 3.91e-34

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 123.47  E-value: 3.91e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46371195      6 VMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLGLSVSKPAVISSLEQGKEPWM 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-515 2.84e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 312 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 380
Cdd:COG5048 268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 381 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 458
Cdd:COG5048 348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46371195 459 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 515
Cdd:COG5048 407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 8.18e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 46371195   287 ELTLHQRIHTGEKPYECKECGKAFRQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 3.91e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 123.47  E-value: 3.91e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46371195      6 VMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLGLSVSKPAVISSLEQGKEPWM 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.75e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 1.75e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46371195     5 LVMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 1.66e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 1.66e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 46371195   6 VMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSL 45
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-515 2.84e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 312 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 380
Cdd:COG5048 268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 381 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 458
Cdd:COG5048 348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46371195 459 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 515
Cdd:COG5048 407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-478 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....
gi 46371195   455 HLKRHQRIHTGEKPHECMICGKAF 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 8.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 46371195   287 ELTLHQRIHTGEKPYECKECGKAFRQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 3.91e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 123.47  E-value: 3.91e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 46371195      6 VMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLGLSVSKPAVISSLEQGKEPWM 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 5-46 1.75e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 1.75e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46371195     5 LVMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSLG 46
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 1.66e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 1.66e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 46371195   6 VMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVSL 45
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
312-515 2.84e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 312 QRSQLTQHQRLHTGE-----KPYECKQCGKAFIRGFQLTEHLR--LHTGE--KPYECKE--CGKTFRHRSHLTIHQRIHT 380
Cdd:COG5048 268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 381 GEKPYECRECgkafsyHSSFSHHQKIHSgkkpyechecgkafcDGLQLTLHQRIHTGEKPYEC--KECGKTFRQCSHLKR 458
Cdd:COG5048 348 SISPAKEKLL------NSSSKFSPLLNN---------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSL 406

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46371195 459 HQRIHTGEKPHECM--ICGKAFRLHSHLIQHQRIHTGEKPYECkECGKAFSYHSSFSHH 515
Cdd:COG5048 407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-561 8.86e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 229 NTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLK-HLRIHNGEKRYECNECGKAFNYG--SELTLHQRIHTGEKPYE--- 302
Cdd:COG5048  17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLnsk 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 303 --------------------------CKECGKAFRQRSQLTQHQRLHTGEKPYECKQCGKAFIRGFQ------------- 343
Cdd:COG5048  97 slplsnskasssslsssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpansl 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 344 ---------LTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGKAFSYH------SSFSHHQKIHS 408
Cdd:COG5048 177 skdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSS 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 409 GKKPYECHECGKAFCDGLQLTLHQRIHTG-EKPYECKECGKTFRQCSHLKRHQR--IHTGE--KPHEC--MICGKAFRLH 481
Cdd:COG5048 257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 482 SHLIQHQRIHTGEKPYECK--ECGKAFS------YHSSFSHHQRIHSGKKPYQ----CGKAFNHRLQLNLHQTLHTGEKP 549
Cdd:COG5048 337 DALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKNDKKSETlsnsCIRNFKRDSNLSLHIITHLSFRP 416

                       410
                ....*....|..
gi 46371195 550 VRFPLLPPHPSL 561
Cdd:COG5048 417 YNCKNPPCSKSF 428
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
467-563 1.47e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 467 KPHECMICGKAFRLHSHLIQHQRIHTGEKPYEC--KECGKAFSYHSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLH 544
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90
                ....*....|....*....
gi 46371195 545 TGEKPVRFPLLPPHPSLAS 563
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPP 130
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-420 2.45e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 191 ISECKKCRKIFSYHLFFSHHKRTHSKELSECKECTEIVN-TPCLFKQQTIQNGDKCNECKECWKAF---VHCSQLKHLRI 266
Cdd:COG5048 199 SSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPkSLLSQSPSSLSSSDSSSSASESPRSSlptASSQSSSPNES 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 267 HNGE-----KRYECNECGKAFNYGSELTLHQR--IHTGE--KPYECKE--CGKAFRQRSQLTQHQRLHTGEKPYECKQC- 334
Cdd:COG5048 279 DSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLn 358

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 335 ------GKAFIRGFQLTEHLRLHTGEKPYEC--KECGKTFRHRSHLTIHQRIHTGEKPYECR--ECGKAFSYHSSFSHHQ 404
Cdd:COG5048 359 ssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHK 438

                       250
                ....*....|....*.
gi 46371195 405 KIHSGKKPYECHECGK 420
Cdd:COG5048 439 KIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-527 4.12e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 383 KPYECRECGKAFSYHSSFSHHQ--KIHSGK--KPYECHE--CGKAFCDGLQLTLHQRIHTGEKPYECK--ECGKTFRQCS 454
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 455 HLKRHQRIH-----TGEKPHEC-MICGKAFRLHSHLIQHQRI-HTGEKPYECK--ECGKAFSYHSSFSHHQRIHSGKKPY 525
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETlSNSCIRNFKRDSNLSLHIItHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447


                ..
gi 46371195 526 QC 527
Cdd:COG5048 448 LC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-478 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....
gi 46371195   455 HLKRHQRIHTGEKPHECMICGKAF 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
483-508 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 46371195   483 HLIQHQRIHTGEKPYECKECGKAFSY 508
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 7.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 46371195   371 HLTIHQRIHTGEKPYECRECGKAFSY 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-403 8.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 228 VNTPCLFKQQTIQNGDKCNECKECwkafvhCSQLKHLR------IHNGE--KRYECNE--CGKAFNYGSELTLHQRIHTG 297
Cdd:COG5048 275 PNESDSSSEKGFSLPIKSKQCNIS------FSRSSPLTrhlrsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 298 EKPYECK--ECGKAFRQRS-----QLTQHQRLHTGEKPYEC--KQCGKAFIRGFQLTEHLRLHTGEKPYECK--ECGKTF 366
Cdd:COG5048 349 ISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 46371195 367 RHRSHLTIHQRIHTGEKPYECRECGKaFSYHSSFSHH 403
Cdd:COG5048 429 NRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 8.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 46371195   287 ELTLHQRIHTGEKPYECKECGKAFRQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 441-463 1.06e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.06e-03
                          10        20
                  ....*....|....*....|...
gi 46371195   441 YECKECGKTFRQCSHLKRHQRIH 463
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 1.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*
gi 46371195   316 LTQHQRLHTGEKPYECKQCGKAFIR 340
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 357-379 1.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|...
gi 46371195   357 YECKECGKTFRHRSHLTIHQRIH 379
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-452 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*
gi 46371195   428 LTLHQRIHTGEKPYECKECGKTFRQ 452
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-368 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|....*
gi 46371195   344 LTEHLRLHTGEKPYECKECGKTFRH 368
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 437-515 2.73e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46371195 437 GEKPYECK--ECGKTFRQCSHLKRHQRI-HTGEKPHEcmicgkafrlHSHLIQHQRIHTGEKPYECKECGKAF------S 507
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYknlnglK 415


                ....*...
gi 46371195 508 YHSSFSHH 515
Cdd:COG5189 416 YHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 301-323 7.06e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.06e-03
                          10        20
                  ....*....|....*....|...
gi 46371195   301 YECKECGKAFRQRSQLTQHQRLH 323
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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