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Conserved domains on  [gi|27436940|ref|NP_774959|]
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reelin isoform b precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1605-1774 4.07e-116

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197348  Cd Length: 170  Bit Score: 365.39  E-value: 4.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1605 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQL 1684
Cdd:cd10040    1 GFQDKFDGSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1685 QYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVL 1764
Cdd:cd10040   81 QYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVL 160

                        170
                 ....*....|
gi 27436940 1765 ASGCPWMCSG 1774
Cdd:cd10040  161 ASGCPWMCSG 170
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 867-1034 2.35e-111

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197346  Cd Length: 168  Bit Score: 351.53  E-value: 2.35e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  867 NSISLDFTNLVEVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDN 946
Cdd:cd10038    1 NSISLDFSNLVEVTQSLGFYLGNVQPYCNHDWTLCFTGDSKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  947 QVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDS 1026
Cdd:cd10038   81 QVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDEWALDN 160


                 ....*...
gi 27436940 1027 IYIGQQCP 1034
Cdd:cd10038  161 IYIGQQCP 168
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1956-2130 7.72e-107

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197349  Cd Length: 174  Bit Score: 338.69  E-value: 7.72e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1956 MLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSS 2035
Cdd:cd10041    1 LLLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2036 ADPVRLEFSRDFGATWHLLLPLCYHsSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAG 2115
Cdd:cd10041   81 ADPVRLEFSRDFGATWHLLLPLCYG-SSSISSLCSTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAG 159

                        170
                 ....*....|....*
gi 27436940 2116 SQPVTWAIDNVYIGP 2130
Cdd:cd10041  160 SQPVTWAIDNVYIGP 174
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 3266-3426 8.34e-107

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 338.31  E-value: 8.34e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSC 3345
Cdd:cd10052    1 PSYIKDNFESGSVSELKWSLIQGGGIGSGCGQLAPHAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3346 NSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEV 3425
Cdd:cd10052   81 NINLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEV 160


                 .
gi 27436940 3426 V 3426
Cdd:cd10052  161 V 161
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2322-2478 1.17e-105

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197350  Cd Length: 157  Bit Score: 334.57  E-value: 1.17e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2322 VLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSV 2401
Cdd:cd10042    1 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYAIELEYSV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940 2402 DLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 2478
Cdd:cd10042   81 DLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 157
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2669-2853 2.30e-105

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197351  Cd Length: 171  Bit Score: 334.59  E-value: 2.30e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2669 VMLDTFSSAPVPQHERSPadagpvgriafdmfmEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSH-DGREVYAVTHDL 2747
Cdd:cd10043    1 VLLDTFSSANLPQHERSP---------------EDKTTVNDHWLFHDNCSIERFCDSPDGVMICGSHdDGREVSAVTHDL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2748 TPTEGWIMQFKISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESL 2827
Cdd:cd10043   66 TPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCGGSVTQPSVFFPSKGWRRVTIPLPDKL 145

                        170       180
                 ....*....|....*....|....*.
gi 27436940 2828 VGNPVRFRFYQKYSDMQWAIDNFYLG 2853
Cdd:cd10043  146 VGRPIRFRFYQKASDMQWALDNFYIG 171
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2889-3050 3.23e-105

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197359  Cd Length: 162  Bit Score: 333.67  E-value: 3.23e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2889 KTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRP 2968
Cdd:cd10051    1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2969 ICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVERAQWALDNILI 3048
Cdd:cd10051   81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVSGTERAQWALDNILI 160


                 ..
gi 27436940 3049 GG 3050
Cdd:cd10051  161 GG 162
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1240-1409 2.38e-104

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197347  Cd Length: 170  Bit Score: 331.40  E-value: 2.38e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1240 YEKPAFDYPMNQMSVWLMLANEGMVKNETfCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPV 1319
Cdd:cd10039    1 YEKPAFDYPLNQMSVWLMLSNEGMGKNES-CSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1320 LLQYSHDAGMSWFLVKEGCYPASAG-KGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNV 1398
Cdd:cd10039   80 LLQYSHDAGLTWSLVREGCYPASPGsKGCEGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                        170
                 ....*....|.
gi 27436940 1399 PPFGLDGVYIS 1409
Cdd:cd10039  160 PPFGLDGVYIS 170
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1065-1220 1.19e-103

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 328.73  E-value: 1.19e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1065 LPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCN 1144
Cdd:cd10046    1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSASCN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1145 KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIIL 1220
Cdd:cd10046   81 YPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 3055-3229 1.38e-101

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197352  Cd Length: 176  Bit Score: 323.71  E-value: 1.38e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3055 PSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEAT-SC 3133
Cdd:cd10044    1 PSSLVETFEDEGTSHDENWEFYPNGVRTDEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVsSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3134 GDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGE 3213
Cdd:cd10044   81 GDLHPVMLEYTTDPRSDHWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTE 160

                        170
                 ....*....|....*.
gi 27436940 3214 ETEKQSWAIDHVYIGE 3229
Cdd:cd10044  161 STEAPSWAIDDVYIGE 176
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 526-671 5.29e-101

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197345  Cd Length: 146  Bit Score: 321.04  E-value: 5.29e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  526 VINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLH 605
Cdd:cd10037    1 PIPPDLQTPATKFCLRQKSHGGHNRNVWAVDFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLH 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940  606 TECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIG 671
Cdd:cd10037   81 TECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWAIDNVYIG 146
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2514-2661 1.93e-100

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 319.47  E-value: 1.93e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2514 LPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQG 2593
Cdd:cd10050    1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 2594 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2661
Cdd:cd10050   81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2165-2314 1.67e-99

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 316.84  E-value: 1.67e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2165 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQ 2244
Cdd:cd10049    1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2245 PVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd10049   81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 150
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1447-1597 5.06e-99

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197355  Cd Length: 151  Bit Score: 315.60  E-value: 5.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1447 HNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRT 1526
Cdd:cd10047    1 PSEFFDRFEGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1527 RNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1597
Cdd:cd10047   81 RNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWALDDVLIG 151
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1800-1949 5.05e-98

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 312.59  E-value: 5.05e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1800 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSHS 1879
Cdd:cd10048    1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1880 ILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGN 1949
Cdd:cd10048   81 VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 708-862 1.27e-96

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


:

Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 308.65  E-value: 1.27e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 787
Cdd:cd10045    1 PGFLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940  788 PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMT 862
Cdd:cd10045   81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 202-351 1.55e-87

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


:

Pssm-ID: 197344  Cd Length: 151  Bit Score: 282.44  E-value: 1.55e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYGPRELITTGLNTTTASVLQFSIGSGSCRFSYSDPS 281
Cdd:cd10036    1 LRDDFDSYPLLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDPS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940  282 IIVLYAKNN-SADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGEVYEACWALDNILII 351
Cdd:cd10036   81 IIVSYAVNNtSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYESCWALDNVLII 151
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 48-178 2.55e-21

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


:

Pssm-ID: 260081  Cd Length: 135  Bit Score: 92.45  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940   48 GDGEQGEVLISLHIAGNptYYVPGQEYHVTIS--TSTFFDGLLVTglytSTSVQASQSIGGSSAFGfgiMSDHQFGNQFM 125
Cdd:cd08544   12 GDPQTTPSPYSITVSGN--TYKPGQTYTVTLSgsRPTPFRGFLLQ----ARDASSNEPVGTFQLPP---DSGTKLLTCCP 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27436940  126 CSVVASHVSHLPTTNLSFIWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLC 178
Cdd:cd08544   83 SGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135
Reelin_subrepeat_like super family cl15240
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 421-556 3.35e-19

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


The actual alignment was detected with superfamily member cd08526:

Pssm-ID: 197448 [Multi-domain]  Cd Length: 152  Bit Score: 86.90  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  421 SEEFESQPT----GWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGG-----ICDPGNSHE 491
Cdd:cd08526    3 KDSFEGSLSssdnWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSksqtsTCNPPDSRS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940  492 NDIILYAKIEGrkeHIT---LDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd08526   83 EGVLLQYSVNG---GITwhlLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALD 147
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2136-2159 1.26e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.56  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*
gi 27436940   2136 CNGQGSCINGT-KCICDPGYSGPTC 2159
Cdd:pfam07974    2 CSGRGTCVNQCgKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1037-1059 9.64e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 9.64e-04
                           10        20
                   ....*....|....*....|....*
gi 27436940   1037 CSGHGSCDH--GICRCDQGYQGTEC 1059
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 3231-3259 1.04e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.82  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 27436940   3231 CPKLCSGHGYCTTGAiCICDESFQGDDCS 3259
Cdd:pfam18720    2 CPLGCSSRGVCVDGQ-CICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1772-1794 1.40e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*
gi 27436940   1772 CSGRGICDA--GRCVCDRGFGGPYC 1794
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2860-2882 3.04e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 3.04e-03
                           10        20
                   ....*....|....*....|....*
gi 27436940   2860 CRGHGDCLRE--QCICDPGYSGPNC 2882
Cdd:pfam07974    2 CSGRGTCVNQcgKCVCDSGYQGATC 26
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1406-1440 7.93e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


:

Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.02  E-value: 7.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 27436940   1406 VYISEPC--PSYCSGHGDCISGVCFCDLGYTAAQGTC 1440
Cdd:pfam01683   16 VAPGESCeaDEQCPGGSVCVNGVCQCPPGFTPVNGRC 52
 
Name Accession Description Interval E-value
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1605-1774 4.07e-116

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 365.39  E-value: 4.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1605 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQL 1684
Cdd:cd10040    1 GFQDKFDGSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1685 QYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVL 1764
Cdd:cd10040   81 QYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVL 160

                        170
                 ....*....|
gi 27436940 1765 ASGCPWMCSG 1774
Cdd:cd10040  161 ASGCPWMCSG 170
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 867-1034 2.35e-111

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 351.53  E-value: 2.35e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  867 NSISLDFTNLVEVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDN 946
Cdd:cd10038    1 NSISLDFSNLVEVTQSLGFYLGNVQPYCNHDWTLCFTGDSKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  947 QVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDS 1026
Cdd:cd10038   81 QVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDEWALDN 160


                 ....*...
gi 27436940 1027 IYIGQQCP 1034
Cdd:cd10038  161 IYIGQQCP 168
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1956-2130 7.72e-107

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 338.69  E-value: 7.72e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1956 MLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSS 2035
Cdd:cd10041    1 LLLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2036 ADPVRLEFSRDFGATWHLLLPLCYHsSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAG 2115
Cdd:cd10041   81 ADPVRLEFSRDFGATWHLLLPLCYG-SSSISSLCSTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAG 159

                        170
                 ....*....|....*
gi 27436940 2116 SQPVTWAIDNVYIGP 2130
Cdd:cd10041  160 SQPVTWAIDNVYIGP 174
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 3266-3426 8.34e-107

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 338.31  E-value: 8.34e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSC 3345
Cdd:cd10052    1 PSYIKDNFESGSVSELKWSLIQGGGIGSGCGQLAPHAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3346 NSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEV 3425
Cdd:cd10052   81 NINLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEV 160


                 .
gi 27436940 3426 V 3426
Cdd:cd10052  161 V 161
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2322-2478 1.17e-105

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 334.57  E-value: 1.17e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2322 VLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSV 2401
Cdd:cd10042    1 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYAIELEYSV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940 2402 DLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 2478
Cdd:cd10042   81 DLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 157
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2669-2853 2.30e-105

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 334.59  E-value: 2.30e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2669 VMLDTFSSAPVPQHERSPadagpvgriafdmfmEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSH-DGREVYAVTHDL 2747
Cdd:cd10043    1 VLLDTFSSANLPQHERSP---------------EDKTTVNDHWLFHDNCSIERFCDSPDGVMICGSHdDGREVSAVTHDL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2748 TPTEGWIMQFKISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESL 2827
Cdd:cd10043   66 TPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCGGSVTQPSVFFPSKGWRRVTIPLPDKL 145

                        170       180
                 ....*....|....*....|....*.
gi 27436940 2828 VGNPVRFRFYQKYSDMQWAIDNFYLG 2853
Cdd:cd10043  146 VGRPIRFRFYQKASDMQWALDNFYIG 171
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2889-3050 3.23e-105

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 333.67  E-value: 3.23e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2889 KTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRP 2968
Cdd:cd10051    1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2969 ICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVERAQWALDNILI 3048
Cdd:cd10051   81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVSGTERAQWALDNILI 160


                 ..
gi 27436940 3049 GG 3050
Cdd:cd10051  161 GG 162
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1240-1409 2.38e-104

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 331.40  E-value: 2.38e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1240 YEKPAFDYPMNQMSVWLMLANEGMVKNETfCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPV 1319
Cdd:cd10039    1 YEKPAFDYPLNQMSVWLMLSNEGMGKNES-CSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1320 LLQYSHDAGMSWFLVKEGCYPASAG-KGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNV 1398
Cdd:cd10039   80 LLQYSHDAGLTWSLVREGCYPASPGsKGCEGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                        170
                 ....*....|.
gi 27436940 1399 PPFGLDGVYIS 1409
Cdd:cd10039  160 PPFGLDGVYIS 170
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1065-1220 1.19e-103

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 328.73  E-value: 1.19e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1065 LPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCN 1144
Cdd:cd10046    1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSASCN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1145 KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIIL 1220
Cdd:cd10046   81 YPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 3055-3229 1.38e-101

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 323.71  E-value: 1.38e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3055 PSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEAT-SC 3133
Cdd:cd10044    1 PSSLVETFEDEGTSHDENWEFYPNGVRTDEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVsSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3134 GDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGE 3213
Cdd:cd10044   81 GDLHPVMLEYTTDPRSDHWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTE 160

                        170
                 ....*....|....*.
gi 27436940 3214 ETEKQSWAIDHVYIGE 3229
Cdd:cd10044  161 STEAPSWAIDDVYIGE 176
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 526-671 5.29e-101

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 321.04  E-value: 5.29e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  526 VINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLH 605
Cdd:cd10037    1 PIPPDLQTPATKFCLRQKSHGGHNRNVWAVDFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLH 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940  606 TECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIG 671
Cdd:cd10037   81 TECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWAIDNVYIG 146
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2514-2661 1.93e-100

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 319.47  E-value: 1.93e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2514 LPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQG 2593
Cdd:cd10050    1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 2594 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2661
Cdd:cd10050   81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2165-2314 1.67e-99

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 316.84  E-value: 1.67e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2165 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQ 2244
Cdd:cd10049    1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2245 PVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd10049   81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 150
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1447-1597 5.06e-99

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 315.60  E-value: 5.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1447 HNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRT 1526
Cdd:cd10047    1 PSEFFDRFEGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1527 RNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1597
Cdd:cd10047   81 RNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWALDDVLIG 151
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1800-1949 5.05e-98

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 312.59  E-value: 5.05e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1800 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSHS 1879
Cdd:cd10048    1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1880 ILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGN 1949
Cdd:cd10048   81 VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 708-862 1.27e-96

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 308.65  E-value: 1.27e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 787
Cdd:cd10045    1 PGFLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940  788 PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMT 862
Cdd:cd10045   81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 202-351 1.55e-87

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 282.44  E-value: 1.55e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYGPRELITTGLNTTTASVLQFSIGSGSCRFSYSDPS 281
Cdd:cd10036    1 LRDDFDSYPLLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDPS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940  282 IIVLYAKNN-SADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGEVYEACWALDNILII 351
Cdd:cd10036   81 IIVSYAVNNtSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYESCWALDNVLII 151
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 48-178 2.55e-21

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


Pssm-ID: 260081  Cd Length: 135  Bit Score: 92.45  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940   48 GDGEQGEVLISLHIAGNptYYVPGQEYHVTIS--TSTFFDGLLVTglytSTSVQASQSIGGSSAFGfgiMSDHQFGNQFM 125
Cdd:cd08544   12 GDPQTTPSPYSITVSGN--TYKPGQTYTVTLSgsRPTPFRGFLLQ----ARDASSNEPVGTFQLPP---DSGTKLLTCCP 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27436940  126 CSVVASHVSHLPTTNLSFIWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLC 178
Cdd:cd08544   83 SGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 421-556 3.35e-19

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 86.90  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  421 SEEFESQPT----GWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGG-----ICDPGNSHE 491
Cdd:cd08526    3 KDSFEGSLSssdnWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSksqtsTCNPPDSRS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940  492 NDIILYAKIEGrkeHIT---LDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd08526   83 EGVLLQYSVNG---GITwhlLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALD 147
Reeler pfam02014
Reeler domain;
61-160 8.32e-10

Reeler domain;


Pssm-ID: 460411  Cd Length: 130  Bit Score: 59.29  E-value: 8.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940     61 IAGNPTYYVPGQEYHVTISTSTF---FDGLLVtglytstsvQA-SQSIGGSSAFGFGIMSDHQFGNQFM-CSVVASHVSH 135
Cdd:pfam02014   22 ITVSSTSYRPGETITVTLSGASGgpsFKGFLL---------QArDADSGDPDPVGSFSLPDDADTKFLLdCSGKGNAVTH 92

                           90       100
                   ....*....|....*....|....*...
gi 27436940    136 ---LPTTNLSFIWIAPPAGTGCVNFMAT 160
Cdd:pfam02014   93 sntNKKSSVTVTWTAPASGSGCVVFRAT 120
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2136-2159 1.26e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.56  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*
gi 27436940   2136 CNGQGSCINGT-KCICDPGYSGPTC 2159
Cdd:pfam07974    2 CSGRGTCVNQCgKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1037-1059 9.64e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 9.64e-04
                           10        20
                   ....*....|....*....|....*
gi 27436940   1037 CSGHGSCDH--GICRCDQGYQGTEC 1059
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 3231-3259 1.04e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 27436940   3231 CPKLCSGHGYCTTGAiCICDESFQGDDCS 3259
Cdd:pfam18720    2 CPLGCSSRGVCVDGQ-CICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1772-1794 1.40e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*
gi 27436940   1772 CSGRGICDA--GRCVCDRGFGGPYC 1794
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2860-2882 3.04e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 3.04e-03
                           10        20
                   ....*....|....*....|....*
gi 27436940   2860 CRGHGDCLRE--QCICDPGYSGPNC 2882
Cdd:pfam07974    2 CSGRGTCVNQcgKCVCDSGYQGATC 26
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1406-1440 7.93e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.02  E-value: 7.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 27436940   1406 VYISEPC--PSYCSGHGDCISGVCFCDLGYTAAQGTC 1440
Cdd:pfam01683   16 VAPGESCeaDEQCPGGSVCVNGVCQCPPGFTPVNGRC 52
 
Name Accession Description Interval E-value
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1605-1774 4.07e-116

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 365.39  E-value: 4.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1605 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQL 1684
Cdd:cd10040    1 GFQDKFDGSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1685 QYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVL 1764
Cdd:cd10040   81 QYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVL 160

                        170
                 ....*....|
gi 27436940 1765 ASGCPWMCSG 1774
Cdd:cd10040  161 ASGCPWMCSG 170
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 867-1034 2.35e-111

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 351.53  E-value: 2.35e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  867 NSISLDFTNLVEVTQSLGFYLGNVQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDN 946
Cdd:cd10038    1 NSISLDFSNLVEVTQSLGFYLGNVQPYCNHDWTLCFTGDSKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  947 QVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDEWALDS 1026
Cdd:cd10038   81 QVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDEWALDN 160


                 ....*...
gi 27436940 1027 IYIGQQCP 1034
Cdd:cd10038  161 IYIGQQCP 168
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1956-2130 7.72e-107

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 338.69  E-value: 7.72e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1956 MLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSS 2035
Cdd:cd10041    1 LLLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2036 ADPVRLEFSRDFGATWHLLLPLCYHsSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAG 2115
Cdd:cd10041   81 ADPVRLEFSRDFGATWHLLLPLCYG-SSSISSLCSTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAG 159

                        170
                 ....*....|....*
gi 27436940 2116 SQPVTWAIDNVYIGP 2130
Cdd:cd10041  160 SQPVTWAIDNVYIGP 174
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 3266-3426 8.34e-107

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 338.31  E-value: 8.34e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSC 3345
Cdd:cd10052    1 PSYIKDNFESGSVSELKWSLIQGGGIGSGCGQLAPHAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3346 NSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEV 3425
Cdd:cd10052   81 NINLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEV 160


                 .
gi 27436940 3426 V 3426
Cdd:cd10052  161 V 161
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2322-2478 1.17e-105

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 334.57  E-value: 1.17e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2322 VLEDDFTTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYAIELEYSV 2401
Cdd:cd10042    1 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYAIELEYSV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940 2402 DLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 2478
Cdd:cd10042   81 DLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 157
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2669-2853 2.30e-105

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 334.59  E-value: 2.30e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2669 VMLDTFSSAPVPQHERSPadagpvgriafdmfmEDKTSVNEHWLFHDDCTVERFCDSPDGVMLCGSH-DGREVYAVTHDL 2747
Cdd:cd10043    1 VLLDTFSSANLPQHERSP---------------EDKTTVNDHWLFHDNCSIERFCDSPDGVMICGSHdDGREVSAVTHDL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2748 TPTEGWIMQFKISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESL 2827
Cdd:cd10043   66 TPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCGGSVTQPSVFFPSKGWRRVTIPLPDKL 145

                        170       180
                 ....*....|....*....|....*.
gi 27436940 2828 VGNPVRFRFYQKYSDMQWAIDNFYLG 2853
Cdd:cd10043  146 VGRPIRFRFYQKASDMQWALDNFYIG 171
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2889-3050 3.23e-105

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 333.67  E-value: 3.23e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2889 KTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRP 2968
Cdd:cd10051    1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2969 ICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVERAQWALDNILI 3048
Cdd:cd10051   81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVSGTERAQWALDNILI 160


                 ..
gi 27436940 3049 GG 3050
Cdd:cd10051  161 GG 162
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1240-1409 2.38e-104

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 331.40  E-value: 2.38e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1240 YEKPAFDYPMNQMSVWLMLANEGMVKNETfCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPV 1319
Cdd:cd10039    1 YEKPAFDYPLNQMSVWLMLSNEGMGKNES-CSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1320 LLQYSHDAGMSWFLVKEGCYPASAG-KGCEGNSRELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNV 1398
Cdd:cd10039   80 LLQYSHDAGLTWSLVREGCYPASPGsKGCEGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                        170
                 ....*....|.
gi 27436940 1399 PPFGLDGVYIS 1409
Cdd:cd10039  160 PPFGLDGVYIS 170
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1065-1220 1.19e-103

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 328.73  E-value: 1.19e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1065 LPSTIMSDFENQNGWESDWQEVIGGEIVKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESASCN 1144
Cdd:cd10046    1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSASCN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1145 KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIIL 1220
Cdd:cd10046   81 YPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 3055-3229 1.38e-101

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 323.71  E-value: 1.38e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3055 PSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEAT-SC 3133
Cdd:cd10044    1 PSSLVETFEDEGTSHDENWEFYPNGVRTDEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVsSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3134 GDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGE 3213
Cdd:cd10044   81 GDLHPVMLEYTTDPRSDHWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTE 160

                        170
                 ....*....|....*.
gi 27436940 3214 ETEKQSWAIDHVYIGE 3229
Cdd:cd10044  161 STEAPSWAIDDVYIGE 176
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 526-671 5.29e-101

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 321.04  E-value: 5.29e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  526 VINPELQTPATKFCLRQKNHQGHNRNVWAVDFFHVLPVLPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLH 605
Cdd:cd10037    1 PIPPDLQTPATKFCLRQKSHGGHNRNVWAVDFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLH 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940  606 TECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNMWAIDNVYIG 671
Cdd:cd10037   81 TECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWAIDNVYIG 146
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2514-2661 1.93e-100

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 319.47  E-value: 1.93e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2514 LPTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQG 2593
Cdd:cd10050    1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 2594 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2661
Cdd:cd10050   81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2165-2314 1.67e-99

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 316.84  E-value: 1.67e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2165 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQ 2244
Cdd:cd10049    1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2245 PVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd10049   81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 150
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1447-1597 5.06e-99

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 315.60  E-value: 5.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1447 HNEMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRT 1526
Cdd:cd10047    1 PSEFFDRFEGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1527 RNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1597
Cdd:cd10047   81 RNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWALDDVLIG 151
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1800-1949 5.05e-98

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 312.59  E-value: 5.05e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1800 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSHS 1879
Cdd:cd10048    1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1880 ILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIIDGN 1949
Cdd:cd10048   81 VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 708-862 1.27e-96

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 308.65  E-value: 1.27e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 787
Cdd:cd10045    1 PGFLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940  788 PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMT 862
Cdd:cd10045   81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 202-351 1.55e-87

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 282.44  E-value: 1.55e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYGPRELITTGLNTTTASVLQFSIGSGSCRFSYSDPS 281
Cdd:cd10036    1 LRDDFDSYPLLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDPS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940  282 IIVLYAKNN-SADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVGEVYEACWALDNILII 351
Cdd:cd10036   81 IIVSYAVNNtSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYESCWALDNVLII 151
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1069-1219 2.90e-80

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 261.78  E-value: 2.90e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1069 IMSDFENQNGWESDWQEVIGGEIVkpeQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAS--CNKP 1146
Cdd:cd08526    2 LKDSFEGSLSSSDNWSLVSGGEVG---TGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTstCNPP 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940 1147 DSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1219
Cdd:cd08526   79 DSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1449-1597 1.07e-76

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 251.38  E-value: 1.07e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1449 EMFDRFEGKLSP--LWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRT 1526
Cdd:cd08526    1 FLKDSFEGSLSSsdNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436940 1527 RNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1597
Cdd:cd08526   81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHsGKGQDQWALDNILIG 152
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 2891-3049 2.12e-76

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 250.61  E-value: 2.12e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2891 FLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPIC 2970
Cdd:cd08526    1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 2971 RKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFvisngivVSGVERAQWALDNILIG 3049
Cdd:cd08526   81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPS-------HSGKGQDQWALDNILIG 152
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 2517-2660 5.07e-76

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 249.45  E-value: 5.07e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2517 QLKDNFNRAPSS-QNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT------PNN 2589
Cdd:cd08526    1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQtstcnpPDS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 2590 RNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLI 2660
Cdd:cd08526   81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1605-1765 1.80e-73

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 242.66  E-value: 1.80e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1605 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQL 1684
Cdd:cd08525    1 VLLDTFDTLPDSNENWFFYPGGVVKNDCGSTDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNSVML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1685 QYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNVVL 1764
Cdd:cd08525   81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                 .
gi 27436940 1765 A 1765
Cdd:cd08525  161 G 161
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 710-862 1.28e-72

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 239.82  E-value: 1.28e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  710 FISESFGSSRLSSyHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPD 789
Cdd:cd08526    1 FLKDSFEGSLSSS-DNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPD 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940  790 QPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIMT 862
Cdd:cd08526   80 SRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 3268-3426 7.47e-72

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 237.51  E-value: 7.47e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3268 YIKDNFESARVTEANWETIQGGVIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNS 3347
Cdd:cd08526    1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLA---SGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNP 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 3348 dlsgPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEVV 3426
Cdd:cd08526   78 ----PDSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 2518-2661 5.53e-70

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 231.93  E-value: 5.53e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2518 LKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGG-CSRLLVTVDLNLTNAEFIQFYFMYGCLiTPNNRNQGVLL 2596
Cdd:cd08524    1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCS-TPSYSNQPVLL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 2597 EYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2661
Cdd:cd08524   80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 2168-2314 6.88e-70

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 232.12  E-value: 6.88e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2168 FLKDDFEGQLES-DRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCGK-----GVPDP 2241
Cdd:cd08526    1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSqtstcNPPDS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940 2242 RSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd08526   81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEP-RFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 2322-2478 7.63e-68

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 226.48  E-value: 7.63e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2322 VLEDDFTTLDS--RKWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVSTDVAVNEDSFLQIDFAASC-SVTDSCYAIEL 2397
Cdd:cd08525    1 VLLDTFDTLPDsnENWFFYPGGVVKNDCGSTDSALVFTENiGGERYAVTRDLTVNEGYMLQFKINVGCsSTFSSSNSVML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2398 EYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYI 2477
Cdd:cd08525   81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                 .
gi 27436940 2478 G 2478
Cdd:cd08525  161 G 161
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 202-351 2.81e-66

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 221.53  E-value: 2.81e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQlqlnPNIWVECNNCETGEQCGAIMHGNAVTFCEPYGPRELITTGLNTTTASVLQFSIGSGSCRFSYSDPS 281
Cdd:cd08524    1 LKDDFDGYPS----PDNWLLCPGGKTGTVCGALSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQP 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  282 IIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQENLRVgeVYEACWALDNILII 351
Cdd:cd08524   77 VLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRG--VYQATWAIDNVLIG 144
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 2169-2314 5.24e-65

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 217.68  E-value: 5.24e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2169 LKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNED-GLRMLMTRDLDLSHARFVQFFMRLGCGKgvPDPRSQPVL 2247
Cdd:cd08524    1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST--PSYSNQPVL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940 2248 LQYSLNGGLSWSLLQEFLFSnSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd08524   79 LEYSVDNGASWHLLEEIRAD-SFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1957-2129 2.06e-64

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 216.85  E-value: 2.06e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1957 LLDTFDFGPRE-DNWFFYPGGNIGLYCPysskgapEEDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSS 2035
Cdd:cd08525    2 LLDTFDTLPDSnENWFFYPGGVVKNDCG-------STDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2036 ADPVRLEFSRDFGATWHLLLPLCYHSSSHVSslcstEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPag 2115
Cdd:cd08525   75 SNSVMLEYSTDAGLSWHLVQEECLPSSPGCS-----ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYT-- 147

                        170
                 ....*....|....
gi 27436940 2116 SQPVTWAIDNVYIG 2129
Cdd:cd08525  148 SGVQTWAIDNVYIG 161
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1804-1947 7.13e-63

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 212.09  E-value: 7.13e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1804 LKDDFNGNLHP-DLWPEVYGAERGNLNGEtIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKS-------TPE 1875
Cdd:cd08526    2 LKDSFEGSLSSsDNWSLVSGGEVGTGCGV-LASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSqtstcnpPDS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436940 1876 RSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFIID 1947
Cdd:cd08526   81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 868-1030 1.04e-62

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 211.84  E-value: 1.04e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  868 SISLDFTNLVEVTQSLGFYLGNVQPY--CGHDWTLCFTGDSKlasSMRYVETQSMQIGASYMIQFSLVMGCGqkYTPHMD 945
Cdd:cd08525    1 VLLDTFDTLPDSNENWFFYPGGVVKNdcGSTDSALVFTENIG---GERYAVTRDLTVNEGYMLQFKINVGCS--STFSSS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  946 NQVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQ-SYYTAQDEWAL 1024
Cdd:cd08525   76 NSVMLEYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQyGYTSGVQTWAI 155


                 ....*.
gi 27436940 1025 DSIYIG 1030
Cdd:cd08525  156 DNVYIG 161
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1957-2129 2.37e-62

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 209.98  E-value: 2.37e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1957 LLDTFDFGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNEvGEHSITTRDLNVNENTIIQFEINVGCSTDSSSA 2036
Cdd:cd08524    1 LKDDFDGYPSPDNWLLCPGGKTGTVC-----GALSSGNALVFNEPY-GPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2037 DPVRLEFSRDFGATWHLLLplcyhssshvsslcstehhpssTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPaGS 2116
Cdd:cd08524   75 QPVLLEYSVDNGASWHLLE----------------------EIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHR-GV 131

                        170
                 ....*....|...
gi 27436940 2117 QPVTWAIDNVYIG 2129
Cdd:cd08524  132 YQATWAIDNVLIG 144
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1240-1409 8.84e-62

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 209.15  E-value: 8.84e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1240 YEKPAFDYPMNQmSVWLMLANEGMVKNetFCAATPSAMIF-GKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAP 1318
Cdd:cd08525    1 VLLDTFDTLPDS-NENWFFYPGGVVKN--DCGSTDSALVFtENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1319 VLLQYSHDAGMSWFLVKEGCYPASAGKGcegnsrELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQkNV 1398
Cdd:cd08525   78 VMLEYSTDAGLSWHLVQEECLPSSPGCS------ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTS-GV 150

                        170
                 ....*....|.
gi 27436940 1399 PPFGLDGVYIS 1409
Cdd:cd08525  151 QTWAIDNVYIG 161
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 3057-3228 1.60e-61

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 208.38  E-value: 1.60e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3057 QLVDTFDDEGTSHEeNWSFYPNAVRTAgFCGNPSFHLYWPNKKKDktHNALSSRELIIQPGYMMQFKIVVGCEaTSCGDL 3136
Cdd:cd08525    1 VLLDTFDTLPDSNE-NWFFYPGGVVKN-DCGSTDSALVFTENIGG--ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3137 HSVMLEYTKDArSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSvnsssWKRITIQLPDHVSSSATQFRWIQKGEETE 3216
Cdd:cd08525   76 NSVMLEYSTDA-GLSWHLVQEECLPSSPGCSELHPSSVYESSTFNG-----WKRITIPLPNATLSSATRFRWIQYGYTSG 149

                        170
                 ....*....|..
gi 27436940 3217 KQSWAIDHVYIG 3228
Cdd:cd08525  150 VQTWAIDNVYIG 161
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1450-1597 1.76e-61

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 207.67  E-value: 1.76e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1450 MFDRFEGKLSP-LWYKITGAQVGTGCGTLNDGKSLYFNGP-GKREARTVPLDTRNIRLVQFYIQIGSKTsgitcikPRTR 1527
Cdd:cd08524    1 LKDDFDGYPSPdNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST-------PSYS 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1528 NEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQHGK-HSAQWALDDVLIG 1597
Cdd:cd08524   74 NQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLIG 144
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 2323-2478 7.58e-58

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 197.27  E-value: 7.58e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2323 LEDDFTTLDS-RKWLLHPGGTKMPVCG--STGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCS-VTDSCYAIELE 2398
Cdd:cd08524    1 LKDDFDGYPSpDNWLLCPGGKTGTVCGalSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCStPSYSNQPVLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2399 YSVDLGLSWHPLvrdclptnvecsryhlqRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFD-KQQTWAIDNVYI 2477
Cdd:cd08524   81 YSVDNGASWHLL-----------------EEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLI 143


                 .
gi 27436940 2478 G 2478
Cdd:cd08524  144 G 144
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 526-671 2.54e-56

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 193.74  E-value: 2.54e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  526 VINPELQTP----ATKFCLRQKNHQ-----GHNRNVWAV---DFFHVLPVLPSTM-SHMIQFSINLGCG-THQPGNSVSL 591
Cdd:cd08525    1 VLLDTFDTLpdsnENWFFYPGGVVKndcgsTDSALVFTEnigGERYAVTRDLTVNeGYMLQFKINVGCSsTFSSSNSVML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  592 EFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALTRNTRIRWRQTGPILG-NMWAIDNVYI 670
Cdd:cd08525   81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGvQTWAIDNVYI 160


                 .
gi 27436940  671 G 671
Cdd:cd08525  161 G 161
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 2706-2853 9.99e-54

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 186.04  E-value: 9.99e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2706 SVNEHWLFHDDCTVERFC-DSPDGVMLCGSHDGrEVYAVTHDLTPTEGWIMQFKISVGCKvSEKIAQNQIHVQYSTDFGV 2784
Cdd:cd08525   11 DSNENWFFYPGGVVKNDCgSTDSALVFTENIGG-ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSSNSVMLEYSTDAGL 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 2785 SWNYLVPQCLPADPKCSG----SVSQPSVFFptkGWKRITYPLPESLVGNPVRFRFYQKYS---DMQWAIDNFYLG 2853
Cdd:cd08525   89 SWHLVQEECLPSSPGCSElhpsSVYESSTFN---GWKRITIPLPNATLSSATRFRWIQYGYtsgVQTWAIDNVYIG 161
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1073-1219 7.29e-48

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 168.84  E-value: 7.29e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1073 FENQNGWESD-WQEVIGGEIvkpEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESA--SCNKPDSR 1149
Cdd:cd10047    5 FDRFEGKLSPlWYKITGGQV---GTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNgeTCLRPRSR 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1150 EEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPvFSGEDYDQWAVDDIII 1219
Cdd:cd10047   82 NEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP-QHGKPSAQWALDDVLI 150
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1449-1596 7.46e-45

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 160.35  E-value: 7.46e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1449 EMFDRFEGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRTRN 1528
Cdd:cd10045    6 ESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPDRPG 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1529 EGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQH-GKHSAQWALDDVLI 1596
Cdd:cd10045   86 EGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHsGQNQDVWALDEISM 154
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1450-1597 8.87e-45

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 160.72  E-value: 8.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1450 MFDRF--EGKLSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRTR 1527
Cdd:cd10051    4 LKERFdsEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRPTCR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 1528 NEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQP--------QHGKHSAQWALDDVLIG 1597
Cdd:cd10051   84 KEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglvVSGTERAQWALDNILIG 161
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1065-1219 6.55e-44

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 157.69  E-value: 6.55e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1065 LPSTIMSDFENQNgWESDWQEVIGGEIvkpEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGgesasCN 1144
Cdd:cd10050    1 LPTQLKDTFNRAP-SSSNWLTVVGGKL---STVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG-----CL 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1145 -KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1219
Cdd:cd10050   72 iPPSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1072-1219 7.15e-43

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 154.51  E-value: 7.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1072 DFENQNGwESDWQEVIGGeivKPEQGCGVISSGSSLYF-SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesasCNKPDSRE 1150
Cdd:cd08524    4 DFDGYPS-PDNWLLCPGG---KTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG-----CSTPSYSN 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1151 EGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1219
Cdd:cd08524   75 QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1066-1219 2.53e-42

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 153.40  E-value: 2.53e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1066 PSTIMSDFENQNGWESDWQEVIGGeivKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGES--ASC 1143
Cdd:cd10051    1 KTFLKERFDSEEISSDQWLSLEGG---VTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENnmTLC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1144 NKPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQP-------VFSGEDYDQWAVDD 1216
Cdd:cd10051   78 LRPTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglVVSGTERAQWALDN 157


                 ...
gi 27436940 1217 III 1219
Cdd:cd10051  158 ILI 160
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1462-1597 6.95e-42

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 151.92  E-value: 6.95e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1462 WYKITGAQVGT---GCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSgiTCIKPRTRNEGLIVQYSND 1538
Cdd:cd10046   19 WQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSA--SCNYPDSREEGVLLQYSNN 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1539 NGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1597
Cdd:cd10046   97 GGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFsGEGYDQWALDDIIIL 156
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2166-2314 8.05e-41

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 149.23  E-value: 8.05e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFEGQ--LESDRFLLMSGG--KPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLG-----CGK 2236
Cdd:cd10046    2 PSTVMSDFENQdsLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNY 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 2237 gvPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd10046   82 --PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKP-RFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 894-1039 2.48e-40

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 148.13  E-value: 2.48e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  894 CGHDWTLCFTGDSKlasSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPhmDNQVKLEYSTNHGLTWHLVQEECLPSMPS 973
Cdd:cd10040   29 LSMDTALMFTENIG---KPRYAETWDFHVSASTFLQFELSMGCSKPYSN--SHSVQLQYSLNNGRDWHLVTEECVPPAIG 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940  974 CQEFTSASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYT-AQDEWALDSIYIGQQCPNMCSG 1039
Cdd:cd10040  104 CLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYApGADSWAIDNVVLASGCPWMCSG 170
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2515-2662 2.69e-40

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 147.62  E-value: 2.69e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2515 PTQLKDNF-NRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------CLiT 2586
Cdd:cd10051    1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCL-R 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2587 PNNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQP---RHD----GLDQNDWAIDNVL 2659
Cdd:cd10051   80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftiSNGlvvsGTERAQWALDNIL 159


                 ...
gi 27436940 2660 ISG 2662
Cdd:cd10051  160 IGG 162
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1452-1594 4.39e-40

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 147.25  E-value: 4.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1452 DRFEGKLSPL--WYKITGAQVGTGCGTLN---DGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGITC----I 1522
Cdd:cd10052    6 DNFESGSVSElkWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCninlS 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940 1523 KPRTRNEGLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQH-GKHSAQWALDDV 1594
Cdd:cd10052   86 SPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdGTGHDQWALDNV 158
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 726-861 6.02e-40

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 146.50  E-value: 6.02e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  726 FYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGI 805
Cdd:cd10047   16 WYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNEGIIVQYSNDNGI 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940  806 TWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDvWAIDEIIM 861
Cdd:cd10047   96 TWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQ-WALDDVLI 150
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1097-1219 1.61e-38

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 142.25  E-value: 1.61e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1097 GCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGES--ASCNKPDSREEGVLLQYSNNGGIQWHLLAEMYFS 1174
Cdd:cd10045   30 GCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSvlGTCPPPDRPGEGVLLHYSCDNGITWKLLEHYSYD 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 27436940 1175 DFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1219
Cdd:cd10045  110 NYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2894-3049 1.91e-38

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 141.88  E-value: 1.91e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2894 ERFdsEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKE 2973
Cdd:cd10047    6 DRF--EGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNE 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 2974 GVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVisngivvsGVERAQWALDNILIG 3049
Cdd:cd10047   84 GIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH--------GKPSAQWALDDVLIG 151
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2515-2661 2.37e-38

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 141.86  E-value: 2.37e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2515 PTQLKDNFN--RAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT------ 2586
Cdd:cd10045    1 PGFLSESFNssRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcpp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 2587 PNNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2661
Cdd:cd10045   81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1066-1219 4.03e-38

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 141.19  E-value: 4.03e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1066 PSTIMSDFENQNgwESD-WQEVIGGeivKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGgesasCN 1144
Cdd:cd10049    2 PDFLKDDFEGQL--ESDrFLLMSGG---KPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-----CG 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 1145 K--PDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSK-PRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1219
Cdd:cd10049   72 KgvPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNvGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2514-2663 6.24e-38

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 140.40  E-value: 6.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2514 LPTQLKDNFNRAPSSQNWLTVNGGKLSTVCG-AVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNnRNQ 2592
Cdd:cd10048    1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPE-RSH 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 2593 GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLISGS 2663
Cdd:cd10048   80 SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2515-2660 1.18e-37

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 139.65  E-value: 1.18e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2515 PTQLKDNFNRAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGC-LITPNNRNQG 2593
Cdd:cd10049    2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCgKGVPDPRSQP 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 2594 VLLEYSVNGGITWNLLMEIFYDQYSKPG-FVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLI 2660
Cdd:cd10049   82 VLLQYSLNGGLTWSLLQEFLFSNSSNVGrYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2515-2661 2.03e-37

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 139.18  E-value: 2.03e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2515 PTQLKDNFNRApSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------CLiTP 2587
Cdd:cd10047    1 PSEFFDRFEGK-LSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCL-RP 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940 2588 NNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHdGLDQNDWAIDNVLIS 2661
Cdd:cd10047   79 RSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDVLIG 151
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2166-2316 8.28e-37

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 137.32  E-value: 8.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCgKGVPDpRSQ 2244
Cdd:cd10048    2 PSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFIT-KGTPE-RSH 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436940 2245 PVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGN 2316
Cdd:cd10048   80 SVLLQYSINGGITWHLIDEFYFPTTTDV-LFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 708-861 2.12e-36

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 136.52  E-value: 2.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRlSSYHNFYSIRGAEVSF---GCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSvlST 784
Cdd:cd10046    2 PSTVMSDFENQD-SLETEWQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--AS 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940  785 CRAPDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIM 861
Cdd:cd10046   79 CNYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2529-2660 7.82e-36

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 134.59  E-value: 7.82e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2529 QNWLTVNGGKLSTV---CGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT----PNNRNQGVLLEYSVN 2601
Cdd:cd10046   17 TEWQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSAscnyPDSREEGVLLQYSNN 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 2602 GGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLI 2660
Cdd:cd10046   97 GGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2166-2315 1.07e-35

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 134.52  E-value: 1.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLG-------CGKg 2237
Cdd:cd10051    1 KTFLKERFDSEeISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCLR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2238 vPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGR-YIALeiPLKARSGSTRLRWWQP--SENGHFYSP-----WVID 2309
Cdd:cd10051   80 -PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYdYITL--PENARTNSTRLRWWQPftISNGLVVSGteraqWALD 156


                 ....*.
gi 27436940 2310 QILIGG 2315
Cdd:cd10051  157 NILIGG 162
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2515-2658 1.49e-35

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 134.15  E-value: 1.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2515 PTQLKDNFNRAPSSQ-NWLTVNGGKLSTVCGAV---ASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------C 2583
Cdd:cd10052    1 PSYIKDNFESGSVSElKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 2584 ---LITPNNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNV 2658
Cdd:cd10052   81 ninLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2166-2314 2.36e-35

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 133.04  E-value: 2.36e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGCgKGVPDPRSQP 2245
Cdd:cd10050    2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGC-LIPPSNRNQG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 2246 VLLQYSLNGGLSWSLLQEfLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2314
Cdd:cd10050   81 VLLEYSVNGGITWNLLME-IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 2892-3049 7.21e-35

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 131.40  E-value: 7.21e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2892 LKERFDSEEiKPDLWMSLEGGSTCTECGILAEDTALYF-GGSTVRQAVTQDLDLRGAKFLQYWGRIGsennmtsCHRPIC 2970
Cdd:cd08524    1 LKDDFDGYP-SPDNWLLCPGGKTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG-------CSTPSY 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 2971 RKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFvisngivVSGVERAQWALDNILIG 3049
Cdd:cd08524   73 SNQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPN-------HRGVYQATWAIDNVLIG 144
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1626-1769 1.47e-34

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 131.58  E-value: 1.47e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1626 GQVDIDClSMDTALIFT---ENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSH--SVQLQYSLNNGKDWHLVTEE 1700
Cdd:cd10038   22 GNVQPYC-NHDWTLCFTgdsKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMdnQVKLEYSTNHGLTWHLVQEE 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1701 CVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGaDSWAIDNVVLASGCP 1769
Cdd:cd10038  101 CLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQ-DEWALDNIYIGQQCP 168
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2888-3049 1.62e-34

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 130.72  E-value: 1.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2888 LKTFLKERFDSEEIKpDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNmtschr 2967
Cdd:cd10050    1 LPTQLKDTFNRAPSS-SNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2968 PICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPfvisngiVVSGVERAQWALDNIL 3047
Cdd:cd10050   74 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQP-------SHDGLDQNDWAIDNVL 146


                 ..
gi 27436940 3048 IG 3049
Cdd:cd10050  147 IG 148
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 3266-3423 1.79e-34

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 130.71  E-value: 1.79e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESARVTEanWETIQGGVIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSC 3345
Cdd:cd10047    1 PSEFFDRFEGKLSPL--WYKITGGQVGTGCGVIK---DGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETC 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 3346 NSdlsgPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHnGTGHDQWALDHV 3423
Cdd:cd10047   76 LR----PRSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDV 148
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1066-1217 3.21e-34

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 130.30  E-value: 3.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1066 PSTIMSDFENQNGWESDWQEVIGGEIvkpEQGCGVIS---SGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGG--ES 1140
Cdd:cd10052    1 PSYIKDNFESGSVSELKWSLIQGGGI---GSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSrsQT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1141 ASCN----KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDD 1216
Cdd:cd10052   78 DSCNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDN 157


                 .
gi 27436940 1217 I 1217
Cdd:cd10052  158 V 158
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 718-859 9.77e-34

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 128.31  E-value: 9.77e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  718 SRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKD-GRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCrapdqpgEGVL 796
Cdd:cd08524    6 DGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-------QPVL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940  797 LHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEI 859
Cdd:cd08524   79 LEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2918-3049 3.55e-33

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 127.27  E-value: 3.55e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2918 CGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENnmTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQK 2997
Cdd:cd10046   34 CGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--ASCNYPDSREEGVLLQYSNNGGISWKLLAEMYFSD 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27436940 2998 YISVRHDYILLPEDALTNTTRLRWWQPfvisngiVVSGVERAQWALDNILIG 3049
Cdd:cd10046  112 FSKPRFVYLELPTAAKTPCTRFRWWQP-------VFSGEGYDQWALDDIIIL 156
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 3266-3428 4.19e-33

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 126.84  E-value: 4.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESARVT-EANWETIQGGVIGSGCGQLAPyahGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDS 3344
Cdd:cd10045    1 PGFLSESFNSSRLSsYHNFSSIRGGEVGFGCGVLAS---GKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3345 CNSdlsgPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDhvE 3424
Cdd:cd10045   78 CPP----PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALD--E 151


                 ....
gi 27436940 3425 VVLT 3428
Cdd:cd10045  152 ISMT 155
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 708-859 4.61e-33

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 127.20  E-value: 4.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRLSSyHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 787
Cdd:cd10051    1 KTFLKERFDSEEISS-DQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940  788 PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDV-------WAIDEI 859
Cdd:cd10051   80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVsgteraqWALDNI 158
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2891-3048 8.10e-33

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 126.07  E-value: 8.10e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2891 FLKERFDSEEIK-PDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPI 2969
Cdd:cd10045    3 FLSESFNSSRLSsYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPD 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 2970 CRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFvisngivVSGVERAQWALDNILI 3048
Cdd:cd10045   83 RPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPY-------HSGQNQDVWALDEISM 154
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1804-1946 1.24e-32

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 125.23  E-value: 1.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1804 LKDDFNGNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKG-EGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSHSILL 1882
Cdd:cd08524    1 LKDDFDGYPSPDNWLLCPGGKTGTVCG-ALSSGNALVFNEpYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940 1883 QFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFII 1946
Cdd:cd08524   80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1462-1597 5.98e-32

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 123.41  E-value: 5.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1462 WYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGsktsgitC-IKPRTRNEGLIVQYSNDNG 1540
Cdd:cd10050   18 WLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG-------ClIPPSNRNQGVLLEYSVNGG 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 1541 ILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1597
Cdd:cd10050   91 ITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHdGLDQNDWAIDNVLIG 148
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 708-859 1.85e-31

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 122.60  E-value: 1.85e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRLSSYhNFYSIRGAEVSFGCGVL---ASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLST 784
Cdd:cd10052    1 PSYIKDNFESGSVSEL-KWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDS 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940  785 CR----APDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEI 859
Cdd:cd10052   80 CNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 3266-3423 2.95e-31

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 121.81  E-value: 2.95e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESARVTEANWETIQGGVIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSC 3345
Cdd:cd10051    1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLA---EGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3346 NSdlsgPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQP--RHNGTG-----HDQW 3418
Cdd:cd10051   78 LR----PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftISNGLVvsgteRAQW 153


                 ....*
gi 27436940 3419 ALDHV 3423
Cdd:cd10051  154 ALDNI 158
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 3265-3423 3.29e-31

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 121.09  E-value: 3.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3265 LPSYIKDNFESARVTEaNWETIQGGVIGSGCGqlaPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGsmsqtds 3344
Cdd:cd10050    1 LPTQLKDTFNRAPSSS-NWLTVVGGKLSTVCG---AVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG------- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 3345 CNSDlsgPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3423
Cdd:cd10050   70 CLIP---PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNV 145
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1801-1946 4.56e-31

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 120.77  E-value: 4.56e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1801 PSILKDDFNGNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRF-IAKSTPE-RSH 1878
Cdd:cd10049    2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLgCGKGVPDpRSQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1879 SILLQFSISGGITWHLMDEFYFPQTTNI-LFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFII 1946
Cdd:cd10049   81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVgRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2335-2487 9.21e-31

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 120.78  E-value: 9.21e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2335 WLLHPGGTKMPVCGSTGDALVFIEKA-STRYVVSTDVAVNEDSFLQIDFAASCS-VTDSCYAIELEYSVDLGLSWHPLVR 2412
Cdd:cd10040   16 WYRIQGGQVDIDCLSMDTALMFTENIgKPRYAETWDFHVSASTFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTE 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 2413 DCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCIDMCSG 2487
Cdd:cd10040   96 ECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVLASGCPWMCSG 170
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 708-861 1.25e-30

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 119.62  E-value: 1.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFGSSRLSSyhNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSvlstcRA 787
Cdd:cd10049    2 PDFLKDDFEGQLESD--RFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGK-----GV 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940  788 PDQPGEGVLLHYSYDNGITWKLLEHYSYL-SYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIM 861
Cdd:cd10049   75 PDPRSQPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 708-861 1.77e-30

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 119.17  E-value: 1.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  708 PMFISESFgsSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVlstcra 787
Cdd:cd10050    2 PTQLKDTF--NRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------ 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  788 PDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIM 861
Cdd:cd10050   74 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2166-2313 1.78e-30

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 119.52  E-value: 1.78e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFEGQLES--DRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLGcGKGV----- 2238
Cdd:cd10045    1 PGFLSESFNSSRLSsyHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLG-SKSVlgtcp 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 2239 -PDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNvGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQILI 2313
Cdd:cd10045   80 pPDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHE-PRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 3265-3423 2.97e-30

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 118.80  E-value: 2.97e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3265 LPSYIKDNFESARVTEANWETIQGGVI---GSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSmsQ 3341
Cdd:cd10046    1 LPSTVMSDFENQDSLETEWQEVIGGEIvkpEMGCGVIS---SGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGG--G 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3342 TDSCNSdlsgPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALD 3421
Cdd:cd10046   76 SASCNY----PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151


                 ..
gi 27436940 3422 HV 3423
Cdd:cd10046  152 DI 153
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1800-1946 1.61e-29

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 116.47  E-value: 1.61e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1800 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGEtIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPE-RSH 1878
Cdd:cd10050    1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGA-VASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSnRNQ 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 1879 SILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFII 1946
Cdd:cd10050   80 GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1800-1946 3.18e-29

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 115.72  E-value: 3.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1800 LPSILKDDF-NGNLHPDLWPEVYGAE--RGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKS---- 1872
Cdd:cd10046    1 LPSTVMSDFeNQDSLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSascn 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 1873 -TPERSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFII 1946
Cdd:cd10046   81 yPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1608-1762 3.23e-29

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 115.22  E-value: 3.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1608 DKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTENIGkPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQ 1685
Cdd:cd08524    3 DDFDGYPSPD-NWLLCPGGKTGTVCgaLSSGNALVFNEPYG-PRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 1686 YSLNNGKDWHLVTEecvpptigclhytessiYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADS-WAIDNV 1762
Cdd:cd08524   81 YSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQAtWAIDNV 141
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2166-2314 6.87e-29

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 114.53  E-value: 6.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLG-------CGKgv 2238
Cdd:cd10047    1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCLR-- 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 2239 PDPRSQPVLLQYSLNGGLSWSLLQEFLFSnSSNVGRYIALEIPLKARSGSTRLRWWQPSENGHfYSPWVIDQILIG 2314
Cdd:cd10047   78 PRSRNEGIIVQYSNDNGITWHLLRELDFM-SYLEPQVISIELPREAKTPATAFRWWQPQHGKP-SAQWALDDVLIG 151
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1065-1219 7.30e-29

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 114.59  E-value: 7.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1065 LPSTIMSDFeNQNGWESDWQEVIGGEivKPEQGCGVISSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIggesaSCN 1144
Cdd:cd10048    1 LPSVLKDDF-NGNLRPDLWPEVYGAE--RGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-----ITK 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 1145 KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1219
Cdd:cd10048   73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2890-3046 2.89e-28

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 113.35  E-value: 2.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2890 TFLKERFDSEEIKPDLWMSLEGGSTCTECGIL---AEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCH 2966
Cdd:cd10052    2 SYIKDNFESGSVSELKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2967 ----RPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPfvisngiVVSGVERAQWA 3042
Cdd:cd10052   82 inlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQP-------RHDGTGHDQWA 154


                 ....
gi 27436940 3043 LDNI 3046
Cdd:cd10052  155 LDNV 158
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 558-680 3.51e-28

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 113.47  E-value: 3.51e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  558 FHVLPvlpstmSHMIQFSINLGCG-THQPGNSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRIT 636
Cdd:cd10040   52 FHVSA------STFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRIT 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 27436940  637 IPLPNAALTRNTRIRWRQTGPILG-NMWAIDNVYIGPSCLKFCSG 680
Cdd:cd10040  126 VYLPPATISPRTRFRWIQPNYAPGaDSWAIDNVVLASGCPWMCSG 170
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 3269-3423 4.72e-28

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 112.14  E-value: 4.72e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3269 IKDNFESArVTEANWETIQGGVIGSGCGQLApyaHGDSLYFNGCQ-IRQAATKPLDLTRASKIMFVLQIGSMSQTDSCns 3347
Cdd:cd08524    1 LKDDFDGY-PSPDNWLLCPGGKTGTVCGALS---SGNALVFNEPYgPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 3348 dlsgphavdKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3423
Cdd:cd08524   75 ---------QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1452-1597 1.35e-26

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 108.06  E-value: 1.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1452 DRFEGKL-SPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGsktsgitCIK--PRTRN 1528
Cdd:cd10049    7 DDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKgvPDPRS 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1529 EGLIVQYSNDNGILWHLLRELDFM-SFLEPQIISIDLPQDAKTPATAFRWWQP-QHGKHSAQWALDDVLIG 1597
Cdd:cd10049   80 QPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPsENGHFYSPWVIDQILIG 150
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2166-2311 1.98e-26

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 107.96  E-value: 1.98e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2166 PDFLKDDFE-GQLESDRFLLMSGGKPSRKCGILS---SGNNLFFNEDGLRMLMTRDLDLSHARFVQFFMRLG-------C 2234
Cdd:cd10052    1 PSYIKDNFEsGSVSELKWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 2235 GKGV--PDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNvGRYIALEIPLKARSGSTRLRWWQPSENGHFYSPWVIDQI 2311
Cdd:cd10052   81 NINLssPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMR-AQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 925-1030 1.98e-25

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 104.56  E-value: 1.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  925 SYMIQFSLVMGCGqkyTPHMDNQVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFTQWRRVIVLLPQKTWS 1004
Cdd:cd10037   44 THFAQFSINLGCG---SHQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                         90       100
                 ....*....|....*....|....*.
gi 27436940 1005 SATRFRWSQSYYTAQDEWALDSIYIG 1030
Cdd:cd10037  121 SATRFRWRQTGSVVGSMWAIDNVYIG 146
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 569-674 3.11e-25

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 105.00  E-value: 3.11e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  569 SHMIQFSINLGCGTH-QPG--NSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTVYSSENYSGWNRITIPLPNAALT 645
Cdd:cd10038   59 SYMIQFSLVMGCGQQyTPHmdNQVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWS 138

                         90       100
                 ....*....|....*....|....*....
gi 27436940  646 RNTRIRWRQTGPILGNMWAIDNVYIGPSC 674
Cdd:cd10038  139 SATRFRWSQSYYTDQDEWALDNIYIGQQC 167
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1617-1762 5.96e-25

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 103.83  E-value: 5.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1617 QANWYRIQGGQVDIDCLSMDTALIFTENiGKPRYAETWDFHVSASTFLQFEMSMGCSKPfSNSHSVQLQYSLNNGKDWHL 1696
Cdd:cd10042   11 SRKWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVTTDIMVNEDSFLQIDFAASCSVT-DSCYAIELEYSVDLGLSWHP 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1697 VTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAIDNV 1762
Cdd:cd10042   89 LLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNV 154
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1239-1418 7.54e-25

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 103.84  E-value: 7.54e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1239 FYEKpaFDYPMNQMSVWLMLANeGMVKnETFCAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAP 1318
Cdd:cd10040    2 FQDK--FDGSVDLQANWYRIQG-GQVD-IDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1319 VLLQYSHDAGMSWFLVKEGCYPASAgkGCEgnsrELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSqKNV 1398
Cdd:cd10040   78 VQLQYSLNNGRDWHLVTEECVPPAI--GCL----HYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYA-PGA 150

                        170       180
                 ....*....|....*....|
gi 27436940 1399 PPFGLDGVYISEPCPSYCSG 1418
Cdd:cd10040  151 DSWAIDNVVLASGCPWMCSG 170
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2326-2481 9.01e-25

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 103.46  E-value: 9.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2326 DFTTL-DSRKWLLHPGGTKMPVCGS------TGDALvfiEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSC---YAI 2395
Cdd:cd10038    6 DFSNLvEVTQSLGFYLGNVQPYCNHdwtlcfTGDSK---HASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmdNQV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2396 ELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQpAPFDKQQTWAIDNV 2475
Cdd:cd10038   83 KLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQ-SYYTDQDEWALDNI 161


                 ....*.
gi 27436940 2476 YIGDGC 2481
Cdd:cd10038  162 YIGQQC 167
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 3060-3237 1.08e-24

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 103.45  E-value: 1.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3060 DTFDdeGTSH-EENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKThnaLSSRELIIQPGYMMQFKIVVGCeATSCGDLHS 3138
Cdd:cd10040    4 DKFD--GSVDlQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRY---AETWDFHVSASTFLQFELSMGC-SKPYSNSHS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3139 VMLEYTKDARSDsWQLVQTQCLPSSsnsIGCSPFQfhEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEKQ 3218
Cdd:cd10040   78 VQLQYSLNNGRD-WHLVTEECVPPA---IGCLHYT--ESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                        170
                 ....*....|....*....
gi 27436940 3219 SWAIDHVYIGEACPKLCSG 3237
Cdd:cd10040  152 SWAIDNVVLASGCPWMCSG 170
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2891-3049 1.72e-24

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 101.90  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2891 FLKERFDSEeIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIGsennmtsCHR--P 2968
Cdd:cd10049    4 FLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKgvP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2969 ICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHdYILL--PEDALTNTTRLRWWQPfvisngiVVSGVERAQWALDNI 3046
Cdd:cd10049   76 DPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGR-YVALeiPLKARSPSTRLRWWQP-------SENGHFYSPWVIDQI 147


                 ...
gi 27436940 3047 LIG 3049
Cdd:cd10049  148 LIG 150
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1801-1946 2.86e-24

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 101.43  E-value: 2.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1801 PSILKDDFNGNLhPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPE----- 1875
Cdd:cd10047    1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCG-VIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGEtclrp 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940 1876 --RSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYnNGKKEEIWIVDDFII 1946
Cdd:cd10047   79 rsRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQ-HGKPSAQWALDDVLI 150
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 3109-3228 3.01e-24

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 102.21  E-value: 3.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3109 SRELIIQPGYMMQFKIVVGCEATSCGdLHSVMLEYTKDArSDSWQLVQTQCLPSSSNSIGC--SPFQFHEATIYNSVNSS 3186
Cdd:cd10039   50 TRDLTLKPGYVLQFKVNIGCTSEFSS-FAPVLLQYSHDA-GLTWSLVREGCYPASPGSKGCegSSRELREPTVYHTGDYE 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 27436940 3187 SWKRITIQLPDHVSSSATQFRWIQKGE-ETEKQSWAIDHVYIG 3228
Cdd:cd10039  128 DWTRITIPIPRSLAASKTRFRWIQESSsLKNAPPFGLDGVYIS 170
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 3107-3232 3.07e-24

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 101.92  E-value: 3.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3107 LSSRELIIQPGYMMQFKIVVGC-EATSCGDLHSVMLEYTKDaRSDSWQLVQTQCLPSSsnsIGCSpfQFHEATIYNSVNS 3185
Cdd:cd10038   49 VETQSMQIGASYMIQFSLVMGCgQQYTPHMDNQVKLEYSTN-HGLTWHLVQEECLPGM---PSCQ--EFTSGSIYHSSEF 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 27436940 3186 SSWKRITIQLPDHVSSSATQFRWIQKgEETEKQSWAIDHVYIGEACP 3232
Cdd:cd10038  123 TEWRRITLPLPQKTWSSATRFRWSQS-YYTDQDEWALDNIYIGQQCP 168
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1801-1946 4.48e-24

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 101.03  E-value: 4.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1801 PSILKDDFNGNL--HPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKST----- 1873
Cdd:cd10045    1 PGFLSESFNSSRlsSYHNFSSIRGGEVGFGCG-VLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcp 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 1874 -PER-SHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEEIWIVDDFII 1946
Cdd:cd10045   80 pPDRpGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 913-1030 6.52e-24

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 101.05  E-value: 6.52e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  913 RYVETQSMQIGASYMIQFSLVMGCGQKYTpHMdNQVKLEYSTNHGLTWHLVQEECLPSMPS---CQ----EFTSASIYHA 985
Cdd:cd10039   46 RFAVTRDLTLKPGYVLQFKVNIGCTSEFS-SF-APVLLQYSHDAGLTWSLVREGCYPASPGskgCEgssrELREPTVYHT 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 27436940  986 SEFTQWRRVIVLLPQKTWSSATRFRWSQ--SYYTAQDEWALDSIYIG 1030
Cdd:cd10039  124 GDYEDWTRITIPIPRSLAASKTRFRWIQesSSLKNAPPFGLDGVYIS 170
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 910-1030 1.97e-23

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 99.21  E-value: 1.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  910 SSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHmdnQVKLEYSTNHGLTWHLVQEECLPSMPSCQEFTSASIYHASEFT 989
Cdd:cd10042   39 ASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCY---AIELEYSVDLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFN 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27436940  990 QWRRVIVLLPQKTWSSATRFRWSQ-SYYTAQDEWALDSIYIG 1030
Cdd:cd10042  116 KWTRVTLPLPHYTRSQATRFRWHQpAPFDKQQTWAIDNVYIG 157
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1275-1408 2.69e-23

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 99.48  E-value: 2.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1275 SAMIFGKSD-GDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDAGMSWFLVKEGCYpaSAGKGCEGNSRE 1353
Cdd:cd10041   39 SAMVFVSSElGEHSITTRDLDVNENTIIQFEINVGCTTESSSADPVRLEFSRDFGATWHLLLPLCY--GSSSISSLCSTE 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1354 LSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQE-SSSQKNVPPFGLDGVYI 1408
Cdd:cd10041  117 LHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGfHPAGSQPVTWAIDNVYI 172
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1264-1410 3.63e-23

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 99.14  E-value: 3.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1264 VKNETFCAATPSAMIFGKSDGDRF---AVTRDLTLKPGYVLQFKLNIGC--ANQFSSTAPVLLQYSHDAGM-SWFLVKEG 1337
Cdd:cd10044   26 VRTDEFCGNPSFHLTWPNKKKDKThnaLTTRQLIVQPGYMIQFKIVVGCgsVSSCGDLHPVMLEYTTDPRSdHWQLVQTE 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940 1338 CYPASAGK-GCEGNSreLSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNvPPFGLDGVYISE 1410
Cdd:cd10044  106 CLPSSSNSiDCSPFQ--YHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEA-PSWAIDDVYIGE 176
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1801-1948 4.80e-23

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 98.31  E-value: 4.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1801 PSILKDDF-NGNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKSTPE---- 1875
Cdd:cd10051    1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCG-VLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTlclr 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1876 ---RSHSILLQFSISGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPY-------NNGKKEEIWIVDDFI 1945
Cdd:cd10051   80 ptcRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFtisnglvVSGTERAQWALDNIL 159


                 ...
gi 27436940 1946 IDG 1948
Cdd:cd10051  160 IGG 162
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 891-1031 6.67e-23

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 98.37  E-value: 6.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  891 QPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTN-HGLTWHLVQEECLP 969
Cdd:cd10044   29 DEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDpRSDHWQLVQTECLP 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940  970 S---MPSCQEFT--SASIYHASEFTQWRRVIVLLPQKTWSSATRFRWSQ-SYYTAQDEWALDSIYIGQ 1031
Cdd:cd10044  109 SssnSIDCSPFQyhEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQkTESTEAPSWAIDDVYIGE 176
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1269-1413 1.35e-22

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 97.30  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1269 FCAATPSAMIFGKSD---GDRFAVTRDLTLKPGYVLQFKLNIGCANQFSS--TAPVLLQYSHDAGMSWFLVKEGCYPASA 1343
Cdd:cd10038   27 YCNHDWTLCFTGDSKhasSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmDNQVKLEYSTNHGLTWHLVQEECLPGMP 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1344 GkgCEgnsrELSEPTMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNvpPFGLDGVYISEPCP 1413
Cdd:cd10038  107 S--CQ----EFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQD--EWALDNIYIGQQCP 168
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1452-1599 1.94e-22

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 96.10  E-value: 1.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1452 DRFEGKLSP-LWYKITGAQVGTGCG-TLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGSKTSGitcikprTRNE 1529
Cdd:cd10048    7 DDFNGNLRPdLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTP-------ERSH 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1530 GLIVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQPQH-GKHSAQWALDDVLIGMN 1599
Cdd:cd10048   80 SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNsGKKEEVWILDDLVIDGN 150
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2325-2479 3.94e-22

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 96.06  E-value: 3.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2325 DDFTTLDSRKWLLHPGGTKMP-VCGSTGDALVFI--EKASTRYVVST-DVAVNEDSFLQIDFAASCSVTDSC---YAIEL 2397
Cdd:cd10044    9 EDEGTSHDENWEFYPNGVRTDeFCGNPSFHLTWPnkKKDKTHNALTTrQLIVQPGYMIQFKIVVGCGSVSSCgdlHPVML 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2398 EYSVD-LGLSWHPLVRDCLPTNVE---CS--RYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQPAPFDKQQTWA 2471
Cdd:cd10044   89 EYTTDpRSDHWQLVQTECLPSSSNsidCSpfQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWA 168


                 ....*...
gi 27436940 2472 IDNVYIGD 2479
Cdd:cd10044  169 IDDVYIGE 176
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2741-2856 5.76e-22

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 95.37  E-value: 5.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2741 YAVTHDLTPTEGWIMQFKISVGCKVSEKIA-QNQIHVQYSTDFGVSWNYLVPQCLPADPKCSgSVSQPSVFFPT--KGWK 2817
Cdd:cd10038   48 YVETQSMQIGASYMIQFSLVMGCGQQYTPHmDNQVKLEYSTNHGLTWHLVQEECLPGMPSCQ-EFTSGSIYHSSefTEWR 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 27436940 2818 RITYPLPESLVGNPVRFRFYQKY--SDMQWAIDNFYLGPGC 2856
Cdd:cd10038  127 RITLPLPQKTWSSATRFRWSQSYytDQDEWALDNIYIGQQC 167
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1625-1762 1.42e-21

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 94.50  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1625 GGQVDIDCLSMDTALIFTENIGKpRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQLQYSLNNGKDWHLVTEECVPP 1704
Cdd:cd10039   23 GMGKNESCSPTPSAMVFGKSDGD-RFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYSHDAGLTWSLVREGCYPA 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 1705 TIGCLHYT-------ESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYT-VGADSWAIDNV 1762
Cdd:cd10039  102 SPGSKGCEgssrelrEPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSlKNAPPFGLDGV 167
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 914-1030 1.69e-21

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 94.23  E-value: 1.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  914 YVETQSMQIGASYMIQFSLVMGCGQKyTPHMDNQVKLEYSTNHGLTWHLVQEECLPSMPSC-QEFTSASIYHASEftQWR 992
Cdd:cd10043   59 SAVTHDLTPTEGWILQFKISVGCKSS-EKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCgGSVTQPSVFFPSK--GWR 135

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 27436940  993 RVIVLLPQKTWSSATRFRWSQSYYTAQdeWALDSIYIG 1030
Cdd:cd10043  136 RVTIPLPDKLVGRPIRFRFYQKASDMQ--WALDNFYIG 171
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 3118-3228 2.13e-21

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 93.00  E-value: 2.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3118 YMMQFKIVVGCeaTSCGDLHSVMLEYTKDaRSDSWQLVQTQCLPSSsnsigCSPFQFHEATIYNSVNSSSWKRITIQLPD 3197
Cdd:cd10037   45 HFAQFSINLGC--GSHQPGNSVSLEFSTN-HGRSWSLLHTECLPEL-----CAGPHLPHSTVYSSDNYSGWNRITIPLPN 116

                         90       100       110
                 ....*....|....*....|....*....|.
gi 27436940 3198 HVSSSATQFRWIQKGEETEKQsWAIDHVYIG 3228
Cdd:cd10037  117 AALTSATRFRWRQTGSVVGSM-WAIDNVYIG 146
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 48-178 2.55e-21

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


Pssm-ID: 260081  Cd Length: 135  Bit Score: 92.45  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940   48 GDGEQGEVLISLHIAGNptYYVPGQEYHVTIS--TSTFFDGLLVTglytSTSVQASQSIGGSSAFGfgiMSDHQFGNQFM 125
Cdd:cd08544   12 GDPQTTPSPYSITVSGN--TYKPGQTYTVTLSgsRPTPFRGFLLQ----ARDASSNEPVGTFQLPP---DSGTKLLTCCP 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27436940  126 CSVVASHVSHLPTTNLSFIWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLC 178
Cdd:cd08544   83 SGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 741-861 2.96e-21

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 92.64  E-value: 2.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  741 LASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRApdqpgegVLLHYSYDNGITWKLLEHYSYLSYHE 820
Cdd:cd10048   34 IKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS-------VLLQYSINGGITWHLIDEFYFPTTTD 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 27436940  821 PRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEIIM 861
Cdd:cd10048  107 VLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2722-2853 2.99e-21

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 93.35  E-value: 2.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2722 FCDSP-DGVMLCGSHDGrEVYAVTHDLTPTEGWIMQFKISVGCKvSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADP-- 2798
Cdd:cd10039   28 ESCSPtPSAMVFGKSDG-DRFAVTRDLTLKPGYVLQFKVNIGCT-SEFSSFAPVLLQYSHDAGLTWSLVREGCYPASPgs 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 2799 -KCSGS---VSQPSVFFPT--KGWKRITYPLPESLVGNPVRFRFYQKYSDMQ----WAIDNFYLG 2853
Cdd:cd10039  106 kGCEGSsreLREPTVYHTGdyEDWTRITIPIPRSLAASKTRFRWIQESSSLKnappFGLDGVYIS 170
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1659-1764 5.50e-21

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 91.84  E-value: 5.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1659 SASTFLQFEMSMGCSKpFSNSHSVQLQYSLNNGKDWHLVTEECVPPTIGCLHYTESSIYTSERFQNWKRITVYLPLSTIS 1738
Cdd:cd10037   42 TVTHFAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                         90       100
                 ....*....|....*....|....*.
gi 27436940 1739 PRTRFRWIQaNYTVGADSWAIDNVVL 1764
Cdd:cd10037  121 SATRFRWRQ-TGSVVGSMWAIDNVYI 145
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2708-2854 9.84e-21

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 92.16  E-value: 9.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2708 NEHWLFHDDCTVERFC-------DSPDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKvSEKIAQNQIHVQYST 2780
Cdd:cd10041   12 ESNWLFYPGGNTGLYCpyqskgaPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCT-TESSSADPVRLEFSR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2781 DFGVSWNYLVPQCLPADP---KCSGSVSQPSVFFP--TKGWKRITYPLPESLVGNPVRFRFYQKY-----SDMQWAIDNF 2850
Cdd:cd10041   91 DFGATWHLLLPLCYGSSSissLCSTELHPSSVYYTgtTQGWRREVILFGKLHLCGSVRFRWYQGFhpagsQPVTWAIDNV 170


                 ....
gi 27436940 2851 YLGP 2854
Cdd:cd10041  171 YIGP 174
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 3058-3228 1.58e-20

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 91.39  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3058 LVDTFDdEGtSHEENWSFYPNavrtagfcGNPSFHLYWPNKKKDKTHNAL------------SSRELIIQPGYMMQFKIV 3125
Cdd:cd10041    2 LLDTFD-FG-PNESNWLFYPG--------GNTGLYCPYQSKGAPEEDSAMvfvsselgehsiTTRDLDVNENTIIQFEIN 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3126 VGCEATScGDLHSVMLEYTKDARSdSWQLVQTQCLPSSSNSIGCSpFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQ 3205
Cdd:cd10041   72 VGCTTES-SSADPVRLEFSRDFGA-TWHLLLPLCYGSSSISSLCS-TELHPSSVYYTGTTQGWRREVILFGKLHLCGSVR 148

                        170       180
                 ....*....|....*....|....*
gi 27436940 3206 FRWIQ--KGEETEKQSWAIDHVYIG 3228
Cdd:cd10041  149 FRWYQgfHPAGSQPVTWAIDNVYIG 173
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 915-1030 2.79e-20

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 91.00  E-value: 2.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  915 VETQSMQIGASYMIQFSLVMGCGQKYTPhmDNQVKLEYSTNHGLTWHLVQEEC----LPSMPSCQEFTSASIYHASEFTQ 990
Cdd:cd10041   53 ITTRDLDVNENTIIQFEINVGCTTESSS--ADPVRLEFSRDFGATWHLLLPLCygssSISSLCSTELHPSSVYYTGTTQG 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 27436940  991 WRRVIVLLPQKTWSSATRFRWSQSYYTAQDE---WALDSIYIG 1030
Cdd:cd10041  131 WRREVILFGKLHLCGSVRFRWYQGFHPAGSQpvtWAIDNVYIG 173
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1965-2129 5.15e-20

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 89.88  E-value: 5.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1965 PREDNWFFYPGGNIGLYCPYSSKGapeedSAMVFVSNEvGEHSITTRDLNVNENTIIQFEINVGCSTDSSSADPVRLEFS 2044
Cdd:cd10039   11 NQMSVWLMLSNEGMGKNESCSPTP-----SAMVFGKSD-GDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2045 RDFGATWHLLLPLCYHSSSHVSS--LCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPvTWA 2122
Cdd:cd10039   85 HDAGLTWSLVREGCYPASPGSKGceGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAP-PFG 163


                 ....*..
gi 27436940 2123 IDNVYIG 2129
Cdd:cd10039  164 LDGVYIS 170
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 3266-3423 5.50e-20

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 89.19  E-value: 5.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3266 PSYIKDNFESArVTEANWETIQGGVIGSGCGQLAPyahGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGsmsqtdsC 3345
Cdd:cd10049    2 PDFLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSS---GNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------C 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 3346 NSdlSGPHAVDKAVLLQYSVNNGITWHVIAQ-HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3423
Cdd:cd10049   71 GK--GVPDPRSQPVLLQYSLNGGLTWSLLQEfLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQI 147
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1959-2138 5.82e-20

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 89.97  E-value: 5.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1959 DTFD-FGPREDNWFFYPGGNIGLYCPYSskgapeeDSAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVGCSTDSSSAD 2037
Cdd:cd10040    4 DKFDgSVDLQANWYRIQGGQVDIDCLSM-------DTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2038 PVRLEFSRDFGATWHLLLPLCyhsssHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQ 2117
Cdd:cd10040   77 SVQLQYSLNNGRDWHLVTEEC-----VPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                        170       180
                 ....*....|....*....|.
gi 27436940 2118 pvTWAIDNVYIGPQCEEMCNG 2138
Cdd:cd10040  152 --SWAIDNVVLASGCPWMCSG 170
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1956-2129 6.10e-20

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 89.61  E-value: 6.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1956 MLLDTFDFGP-------------REDNWFFYPGGNIGLYCPysskgapEEDSAMVFVSNEVGEH-SITTRDLNVNENTII 2021
Cdd:cd10043    1 VLLDTFSSANlpqherspedkttVNDHWLFHDNCSIERFCD-------SPDGVMICGSHDDGREvSAVTHDLTPTEGWIL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2022 QFEINVGC-STDSSSADPVRLEFSRDFGATWHLLLPLCYhssshvsslcstehhPSSTYYAGTM---------QGWRREV 2091
Cdd:cd10043   74 QFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCL---------------PSDPKCGGSVtqpsvffpsKGWRRVT 138

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 27436940 2092 VHFGKLHLCGSVRFRWYQGFypagsQPVTWAIDNVYIG 2129
Cdd:cd10043  139 IPLPDKLVGRPIRFRFYQKA-----SDMQWALDNFYIG 171
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1954-2129 6.38e-20

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 89.90  E-value: 6.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1954 PVMLLDTFDFGP--REDNWFFYPGGNIG-LYCpysskGAPEedSAMVFVSNEVG--EHSITTRDLNVNENTIIQFEINVG 2028
Cdd:cd10044    1 PSSLVETFEDEGtsHDENWEFYPNGVRTdEFC-----GNPS--FHLTWPNKKKDktHNALTTRQLIVQPGYMIQFKIVVG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2029 CSTDSSSAD--PVRLEFSRDFGAT-WHLLLPLCYHSSSHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRF 2105
Cdd:cd10044   74 CGSVSSCGDlhPVMLEYTTDPRSDhWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQF 153

                        170       180
                 ....*....|....*....|....
gi 27436940 2106 RWYQGFYPAGSQPvtWAIDNVYIG 2129
Cdd:cd10044  154 RWIQKTESTEAPS--WAIDDVYIG 175
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 888-1030 1.01e-19

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 88.25  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  888 GNVQPYCG---HDWTLCFTGDSklasSMRYVETQSMQIGASYMIQFSLVMGCGqkyTPHMDNQ-VKLEYSTNHGLTWHLV 963
Cdd:cd08524   20 GKTGTVCGalsSGNALVFNEPY----GPRELVTTDLNTNEASFLQFYIGSGCS---TPSYSNQpVLLEYSVDNGASWHLL 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940  964 QEeclpsmpscqeftsasiYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQDE--WALDSIYIG 1030
Cdd:cd08524   93 EE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQatWAIDNVLIG 144
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 3067-3228 1.20e-19

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 88.84  E-value: 1.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3067 TSHEENWSFYPNAVrTAGFCGNPSfHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKD 3146
Cdd:cd10043   22 TTVNDHWLFHDNCS-IERFCDSPD-GVMICGSHDDGREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3147 aRSDSWQLVQTQCLPSSSNSIGcspfQFHEATIYnsVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEkqsWAIDHVY 3226
Cdd:cd10043  100 -FGVSWSYVTPQCLPSDPKCGG----SVTQPSVF--FPSKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ---WALDNFY 169


                 ..
gi 27436940 3227 IG 3228
Cdd:cd10043  170 IG 171
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1969-2129 1.29e-19

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 88.42  E-value: 1.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1969 NWFFYPGGNIGLYCpySSKGApeedsAMVFVSNEVGEHSITTrDLNVNENTIIQFEINVGCSTdSSSADPVRLEFSRDFG 2048
Cdd:cd10042   13 KWLLHPGGTKMPVC--GSTGD-----ALVFIEKASTRYVVTT-DIMVNEDSFLQIDFAASCSV-TDSCYAIELEYSVDLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2049 ATWHLLLPLCYhssshVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQgfyPAGSQP-VTWAIDNVY 2127
Cdd:cd10042   84 LSWHPLLRDCL-----PTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQ---PAPFDKqQTWAIDNVY 155


                 ..
gi 27436940 2128 IG 2129
Cdd:cd10042  156 IG 157
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1267-1408 1.48e-19

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 88.84  E-value: 1.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1267 ETFCAATPSAMIFGKSDGDR--FAVTRDLTLKPGYVLQFKLNIGC-ANQFSSTAPVLLQYSHDAGMSWFLVKEGCYPASA 1343
Cdd:cd10043   37 ERFCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDP 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 1344 GKGcegnsRELSEPTMYHTgdFEEWTRITIVIPRSLASSKTRFRWIQESSSQKnvppFGLDGVYI 1408
Cdd:cd10043  117 KCG-----GSVTQPSVFFP--SKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ----WALDNFYI 170
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 421-556 3.35e-19

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 86.90  E-value: 3.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  421 SEEFESQPT----GWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGG-----ICDPGNSHE 491
Cdd:cd08526    3 KDSFEGSLSssdnWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSksqtsTCNPPDSRS 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940  492 NDIILYAKIEGrkeHIT---LDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd08526   83 EGVLLQYSVNG---GITwhlLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALD 147
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 570-671 4.42e-19

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 87.59  E-value: 4.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  570 HMIQFSINLGCGTHQPGN---SVSLEFSTN-HGRSWSLLHTECLP----EICAGPHLPH-STVYSSENYSGWNRITIPLP 640
Cdd:cd10044   64 YMIQFKIVVGCGSVSSCGdlhPVMLEYTTDpRSDHWQLVQTECLPsssnSIDCSPFQYHeASIYSSVNSSVWKRVTIQLP 143

                         90       100       110
                 ....*....|....*....|....*....|..
gi 27436940  641 NAALTRNTRIRWRQ-TGPILGNMWAIDNVYIG 671
Cdd:cd10044  144 DHVSSSATQFRWIQkTESTEAPSWAIDDVYIG 175
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2373-2478 5.89e-19

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 86.07  E-value: 5.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2373 NEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNveCSRYHL--QRILVSDTFNKWTRITLPLPPYTR 2450
Cdd:cd10037   42 TVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPEL--CAGPHLphSTVYSSDNYSGWNRITIPLPNAAL 119

                         90       100
                 ....*....|....*....|....*...
gi 27436940 2451 SQATRFRWHQPAPFDKQQtWAIDNVYIG 2478
Cdd:cd10037  120 TSATRFRWRQTGSVVGSM-WAIDNVYIG 146
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 572-671 6.24e-19

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 86.50  E-value: 6.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  572 IQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTECLPEI--CAGPHLphSTVYSSENYSGWNRITIPLPNAALTRNTR 649
Cdd:cd10042   57 LQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLLRDCLPTNveCSSYHL--QRILVSDTFNKWTRVTLPLPHYTRSQATR 134

                         90       100
                 ....*....|....*....|...
gi 27436940  650 IRWRQTGPI-LGNMWAIDNVYIG 671
Cdd:cd10042  135 FRWHQPAPFdKQQTWAIDNVYIG 157
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2888-3050 9.82e-19

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 85.70  E-value: 9.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2888 LKTFLKERFDsEEIKPDLWMSLEGGSTCTECGILAED-TALYFGGSTVRQAVTQDLDLRGAKFLQYWGRIgsennmtSCH 2966
Cdd:cd10048    1 LPSVLKDDFN-GNLRPDLWPEVYGAERGNLNGETIKSgTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-------ITK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2967 RPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFvisngivVSGVERAQWALDNI 3046
Cdd:cd10048   73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPY-------NSGKKEEVWILDDL 145


                 ....
gi 27436940 3047 LIGG 3050
Cdd:cd10048  146 VIDG 149
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 2517-2661 2.38e-18

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 84.73  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2517 QLKDNFNRAPSSQ-NWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQgVL 2595
Cdd:cd08525    1 VLLDTFDTLPDSNeNWFFYPGGVVKNDCGSTDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNS-VM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2596 LEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPPDAKEIATRFRWWQPrHDGLDQNDWAIDNV 2658
Cdd:cd08525   80 LEYSTDAGLSWHLVQEeclpsspgcselhpssVYEsSTFNGWKRITIPLPNATLSSATRFRWIQY-GYTSGVQTWAIDNV 158


                 ...
gi 27436940 2659 LIS 2661
Cdd:cd08525  159 YIG 161
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1611-1762 2.50e-18

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 85.28  E-value: 2.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1611 DGSIDLQANWYRIQGGQV-DIDCLSMDTALIFT--ENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFS--NSHSVQLQ 1685
Cdd:cd10044   10 DEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPnkKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSScgDLHPVMLE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1686 YSLNNGKD-WHLVTEECVPPT---IGC--LHYTESSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVGADSWAI 1759
Cdd:cd10044   90 YTTDPRSDhWQLVQTECLPSSsnsIDCspFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAI 169


                 ...
gi 27436940 1760 DNV 1762
Cdd:cd10044  170 DDV 172
Reelin_subrepeat_2 cd08526
C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 202-350 4.01e-18

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197343 [Multi-domain]  Cd Length: 152  Bit Score: 83.82  E-value: 4.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQLQLNpniWVECNNCETGEQCGAIMHGNAVTFCEPyGPRELITTGLNTTTASVLQFS--IGSGSCRFSYSD 279
Cdd:cd08526    2 LKDSFEGSLSSSDN---WSLVSGGEVGTGCGVLASGKALYFNGP-GLRQLVTVDLDLTNARFVQFYlrIGSKSQTSTCNP 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940  280 P-----SIIVLYAKNNSADWIQLEKIR-APSNVSTIIHILyLPEDAKGENVQFQWKQEnlRVGEVYEACWALDNILI 350
Cdd:cd08526   78 PdsrseGVLLQYSVNGGITWHLLQELYyDQYSEPRFVSIE-LPLEARTNGTRFRWWQP--SHSGKGQDQWALDNILI 151
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 556-671 8.77e-18

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 83.33  E-value: 8.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  556 DFFHVLPVLPSTMSHMIQFSINLGCGTHQPG-NSVSLEFSTNHGRSWSLLHTECLP-----EIC--AGPHLPHSTVYSSE 627
Cdd:cd10039   45 DRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSfAPVLLQYSHDAGLTWSLVREGCYPaspgsKGCegSSRELREPTVYHTG 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27436940  628 NYSGWNRITIPLPNAALTRNTRIRWRQTGPILGNM--WAIDNVYIG 671
Cdd:cd10039  125 DYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAppFGLDGVYIS 170
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2322-2478 1.09e-17

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 83.30  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2322 VLEDDFTTL-DSRKWLLHPGGTKMPVC-----GSTGD--ALVFIEKASTRYVVST-DVAVNEDSFLQIDFAASCSV-TDS 2391
Cdd:cd10041    1 LLLDTFDFGpNESNWLFYPGGNTGLYCpyqskGAPEEdsAMVFVSSELGEHSITTrDLDVNENTIIQFEINVGCTTeSSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2392 CYAIELEYSVDLGLSWHPLVRDCL---PTNVECS-RYHLQRILVSDTFNKWTRITLPLPPYTRSQATRFRWHQ---PAPf 2464
Cdd:cd10041   81 ADPVRLEFSRDFGATWHLLLPLCYgssSISSLCStELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQgfhPAG- 159

                        170
                 ....*....|....
gi 27436940 2465 DKQQTWAIDNVYIG 2478
Cdd:cd10041  160 SQPVTWAIDNVYIG 173
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2708-2853 1.82e-17

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 82.26  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2708 NEHWLFHDDCTVERFCDSpDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKVSEKIAQnqIHVQYSTDFGVSWN 2787
Cdd:cd10042   11 SRKWLLHPGGTKMPVCGS-TGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYA--IELEYSVDLGLSWH 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2788 YLVPQCLPADPKCSGSVSQPSVFFPT-KGWKRITYPLPESLVGNPVRFRFYQKYS-DMQ--WAIDNFYLG 2853
Cdd:cd10042   88 PLLRDCLPTNVECSSYHLQRILVSDTfNKWTRVTLPLPHYTRSQATRFRWHQPAPfDKQqtWAIDNVYIG 157
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 569-672 2.98e-17

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 82.14  E-value: 2.98e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  569 SHMIQFSINLGCGTHQPG-NSVSLEFSTNHGRSWSLLHTEC-----LPEICAGPHLPHSTVYSSENySGWNRITIPLPNA 642
Cdd:cd10041   63 NTIIQFEINVGCTTESSSaDPVRLEFSRDFGATWHLLLPLCygsssISSLCSTELHPSSVYYTGTT-QGWRREVILFGKL 141

                         90       100       110
                 ....*....|....*....|....*....|...
gi 27436940  643 ALTRNTRIRWRQ---TGPILGNMWAIDNVYIGP 672
Cdd:cd10041  142 HLCGSVRFRWYQgfhPAGSQPVTWAIDNVYIGP 174
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 3063-3228 4.86e-17

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 81.11  E-value: 4.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3063 DDEGTSHEENWSFYPNAVRTAgFCGNPSFHLYWpnKKKDKTHNALSSrELIIQPGYMMQFKIVVGCEAT-SCgdlHSVML 3141
Cdd:cd10042    4 DDFSTLDSRKWLLHPGGTKMP-VCGSTGDALVF--IEKASTRYVVTT-DIMVNEDSFLQIDFAASCSVTdSC---YAIEL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3142 EYTKDArSDSWQLVQTQCLPSSsnsIGCSPFQFHEATIYNSVNSssWKRITIQLPDHVSSSATQFRWIQKGEETEKQSWA 3221
Cdd:cd10042   77 EYSVDL-GLSWHPLLRDCLPTN---VECSSYHLQRILVSDTFNK--WTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWA 150


                 ....*..
gi 27436940 3222 IDHVYIG 3228
Cdd:cd10042  151 IDNVYIG 157
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 1268-1409 4.86e-17

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 80.55  E-value: 4.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1268 TFCAA--TPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPVLLQYSHDAGMSWFLVKEgcypasagk 1345
Cdd:cd08524   24 TVCGAlsSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLEYSVDNGASWHLLEE--------- 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940 1346 gcegnsrelseptmYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYIS 1409
Cdd:cd08524   95 --------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2168-2314 4.87e-17

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 81.40  E-value: 4.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2168 FLKDDFEGQL-ESDRFLLMSGGKPSRKCGILSSGNNLFFNE-DGLRMLMTRDLDLSHARFVQFFMRLGCGKGVPdpRSQP 2245
Cdd:cd10039    1 YEKPAFDYPLnQMSVWLMLSNEGMGKNESCSPTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFS--SFAP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2246 VLLQYSLNGGLSWSLLQEFLFSNSS------------------NVGRY-----IALEIPLKARSGSTRLRWWQPSENGHF 2302
Cdd:cd10039   79 VLLQYSHDAGLTWSLVREGCYPASPgskgcegssrelreptvyHTGDYedwtrITIPIPRSLAASKTRFRWIQESSSLKN 158

                        170
                 ....*....|..
gi 27436940 2303 YSPWVIDQILIG 2314
Cdd:cd10039  159 APPFGLDGVYIS 170
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1976-2132 7.63e-17

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 80.73  E-value: 7.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1976 GNIGLYCPYSS----KGAPEEDSAMVFVSnevgehsitTRDLNVNENTIIQFEINVGCSTDSSSA--DPVRLEFSRDFGA 2049
Cdd:cd10038   22 GNVQPYCNHDWtlcfTGDSKHASSARYVE---------TQSMQIGASYMIQFSLVMGCGQQYTPHmdNQVKLEYSTNHGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2050 TWHLLLPLCyhsssHVSSLCSTEHHPSSTYYAGTMQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSqpvTWAIDNVYIG 2129
Cdd:cd10038   93 TWHLVQEEC-----LPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQD---EWALDNIYIG 164


                 ...
gi 27436940 2130 PQC 2132
Cdd:cd10038  165 QQC 167
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2323-2478 8.97e-17

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 80.75  E-value: 8.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2323 LEDDftTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTR--YVVSTDVAVNEDSFLQIDFAASCSVTD--SCYAIELE 2398
Cdd:cd10043   18 PEDK--TTVNDHWLFHDNCSIERFCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCKSSEksAQQPVHVQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2399 YSVDLGLSWHPLVRDCLPTNVECSRYHLQRIlVSDTFNKWTRITLPLPPYTRSQATRFRWHQPApfdKQQTWAIDNVYIG 2478
Cdd:cd10043   96 YSTDFGVSWSYVTPQCLPSDPKCGGSVTQPS-VFFPSKGWRRVTIPLPDKLVGRPIRFRFYQKA---SDMQWALDNFYIG 171
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1607-1762 1.02e-16

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 80.60  E-value: 1.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1607 QDKFD-GSIDlqANWYRIQGGQVDIDCLSM-------DTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSN 1678
Cdd:cd10041    3 LDTFDfGPNE--SNWLFYPGGNTGLYCPYQskgapeeDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1679 SHSVQLQYSLNNGKDWHLVTEECVPPTIGCLHYTE----SSIYTSERFQNWKRITVYLPLSTISPRTRFRWIQANYTVG- 1753
Cdd:cd10041   81 ADPVRLEFSRDFGATWHLLLPLCYGSSSISSLCSTelhpSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAGs 160

                        170
                 ....*....|
gi 27436940 1754 -ADSWAIDNV 1762
Cdd:cd10041  161 qPVTWAIDNV 170
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2734-2853 2.03e-16

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 78.75  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2734 SHDG--REVYAVTH-----DLTPTEGWIMQFKISVGCKVSEKiaQNQIHVQYSTDFGVSWNYLVPQCLPAdpKCSGSVSQ 2806
Cdd:cd10037   19 SHGGhnRNVWAVDFfhllpVLPSTVTHFAQFSINLGCGSHQP--GNSVSLEFSTNHGRSWSLLHTECLPE--LCAGPHLP 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27436940 2807 PSVFFPT---KGWKRITYPLPESLVGNPVRFRFYQKYSDM--QWAIDNFYLG 2853
Cdd:cd10037   95 HSTVYSSdnySGWNRITIPLPNAALTSATRFRWRQTGSVVgsMWAIDNVYIG 146
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1801-1942 2.25e-16

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 79.07  E-value: 2.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1801 PSILKDDFNGNLHPDL-WPEVYGAERGNLNGETIK--SGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRF--------- 1868
Cdd:cd10052    1 PSYIKDNFESGSVSELkWSLIQGGGIGSGCGQLAPhaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIgsrsqtdsc 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1869 -IAKSTPE-RSHSILLQFSISGGITWHLMDEF---YFPQTTNILFiNVPLPytAQTNATRFRLWQPYNNGKKEEIWIVD 1942
Cdd:cd10052   81 nINLSSPRaVDKAVLLQYSVNNGITWYLIAQHqpkDFMRAQRVSY-NLPLE--ARTKGVVLRWWQPRHDGTGHDQWALD 156
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 572-671 2.49e-16

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 78.62  E-value: 2.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  572 IQFSINLGCGTHQPGN-SVSLEFSTNHGRSWSLLHTeclpeicagphlphstvYSSENYSGWNRITIPLPNAALTRNTRI 650
Cdd:cd08524   59 LQFYIGSGCSTPSYSNqPVLLEYSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRF 121

                         90       100
                 ....*....|....*....|...
gi 27436940  651 RWRQTGP--ILGNMWAIDNVYIG 671
Cdd:cd08524  122 RWWQPNHrgVYQATWAIDNVLIG 144
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 423-556 3.85e-16

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 78.35  E-value: 3.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  423 EFESQ----PTGWDVLGAVIGTE---CGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGG---ICDPGNSHEN 492
Cdd:cd10046    8 DFENQdsleTEWQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGgsaSCNYPDSREE 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  493 DIILYAKIEGRKEHITLDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd10046   88 GVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1646-1764 5.43e-16

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 78.44  E-value: 5.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1646 GKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHS-VQLQYSLNNGKDWHLVTEECVPPTIGCL-HYTESSIYTSerFQ 1723
Cdd:cd10043   55 GREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQQpVHVQYSTDFGVSWSYVTPQCLPSDPKCGgSVTQPSVFFP--SK 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27436940 1724 NWKRITVYLPLSTISPRTRFRWIQ-ANYTvgadSWAIDNVVL 1764
Cdd:cd10043  133 GWRRVTIPLPDKLVGRPIRFRFYQkASDM----QWALDNFYI 170
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2723-2862 5.49e-16

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 78.41  E-value: 5.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2723 CDSPDGVMLCGSHDGREVYAVTHDLTPTEGWIMQFKISVGCKVSEKiAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSg 2802
Cdd:cd10040   28 CLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYS-NSHSVQLQYSLNNGRDWHLVTEECVPPAIGCL- 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27436940 2803 SVSQPSVFFPTK--GWKRITYPLPESLVGNPVRFRFYQKY----SDMqWAIDNFYLGPGCLDNCRG 2862
Cdd:cd10040  106 HYTESSVYSSERfqNWKRITVYLPPATISPRTRFRWIQPNyapgADS-WAIDNVVLASGCPWMCSG 170
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2698-2853 5.91e-16

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 78.34  E-value: 5.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2698 DMFMEDKTSVNEHWLFHDDCTV-ERFCDSPDGVMLCGSH--DGREVYAVTHDLTPTEGWIMQFKISVGCK-VSEKIAQNQ 2773
Cdd:cd10044    6 ETFEDEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPNKkkDKTHNALTTRQLIVQPGYMIQFKIVVGCGsVSSCGDLHP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2774 IHVQYSTD-FGVSWNYLVPQCLPAD---PKCSG-SVSQPSVFFPTKG--WKRITYPLPESLVGNPVRFRFYQKYSDM--- 2843
Cdd:cd10044   86 VMLEYTTDpRSDHWQLVQTECLPSSsnsIDCSPfQYHEASIYSSVNSsvWKRVTIQLPDHVSSSATQFRWIQKTESTeap 165

                        170
                 ....*....|
gi 27436940 2844 QWAIDNFYLG 2853
Cdd:cd10044  166 SWAIDDVYIG 175
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 3265-3421 6.19e-16

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 77.62  E-value: 6.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3265 LPSYIKDNF-ESARVTEanWETIQGGVIGSGCGQlaPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIgsmsqtd 3343
Cdd:cd10048    1 LPSVLKDDFnGNLRPDL--WPEVYGAERGNLNGE--TIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF------- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 3344 SCNSDLSGPHAVdkavLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALD 3421
Cdd:cd10048   70 ITKGTPERSHSV----LLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILD 143
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 571-671 6.39e-16

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 78.05  E-value: 6.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  571 MIQFSINLGCG--THQPGNSVSLEFSTNHGRSWSLLHTECLP-EICAGPHLPHSTVYSSENysGWNRITIPLPNAALTRN 647
Cdd:cd10043   72 ILQFKISVGCKssEKSAQQPVHVQYSTDFGVSWSYVTPQCLPsDPKCGGSVTQPSVFFPSK--GWRRVTIPLPDKLVGRP 149

                         90       100
                 ....*....|....*....|....
gi 27436940  648 TRIRWRQTGPILgnMWAIDNVYIG 671
Cdd:cd10043  150 IRFRFYQKASDM--QWALDNFYIG 171
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2340-2478 8.02e-16

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 77.94  E-value: 8.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2340 GGTKMPVCGSTGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSCYA-IELEYSVDLGLSWHpLVRD-CLPT 2417
Cdd:cd10039   23 GMGKNESCSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFApVLLQYSHDAGLTWS-LVREgCYPA 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 2418 N---VEC----------SRYHlqrilvSDTFNKWTRITLPLPPYTRSQATRFRWHQPA-PFDKQQTWAIDNVYIG 2478
Cdd:cd10039  102 SpgsKGCegssrelrepTVYH------TGDYEDWTRITIPIPRSLAASKTRFRWIQESsSLKNAPPFGLDGVYIS 170
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1270-1408 1.10e-15

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 77.25  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1270 CAATPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQfSSTAPVLLQYSHDAGMSWFLVKEGCYPASAgkgcEG 1349
Cdd:cd10042   26 CGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVT-DSCYAIELEYSVDLGLSWHPLLRDCLPTNV----EC 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1350 NSRELSEptMYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNvPPFGLDGVYI 1408
Cdd:cd10042  101 SSYHLQR--ILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQ-QTWAIDNVYI 156
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 1462-1596 1.52e-15

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 76.36  E-value: 1.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1462 WYKITGAQVGTGCGTLNDGKSLYFNGP-GKREARTVPLDTRNIRLVQFYIQIGSKTSGITcikprtrNEGLIVQYSNDNG 1540
Cdd:cd10036   18 WSECCGCNVGEQCGVIMHGNALTFCEPyGPRELITVPLNTTTASVLQFAIGSGSCRFSYS-------DPSIIVSYAVNNT 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1541 IL-WHLLRELDFMSFLEPQIISIDLPQDAKTPATAFRWWQ--PQHGKH-SAQWALDDVLI 1596
Cdd:cd10036   91 SSdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVyESCWALDNVLI 150
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1610-1764 5.85e-15

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 74.88  E-value: 5.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1610 FDGSIDLQANWYRIQGGQV---DIDCLSMDTALIFTENIGKPRYAETWDFHVSASTFLQFEMSMG-----CSKPFSNSHS 1681
Cdd:cd10046    9 FENQDSLETEWQEVIGGEIvkpEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNYPDSREEG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1682 VQLQYSLNNGKDWHLVTEecvpptigcLHYTEssiYTSERFqnwkrITVYLPLSTISPRTRFRWIQANYT-VGADSWAID 1760
Cdd:cd10046   89 VLLQYSNNGGISWKLLAE---------MYFSD---FSKPRF-----VYLELPTAAKTPCTRFRWWQPVFSgEGYDQWALD 151


                 ....
gi 27436940 1761 NVVL 1764
Cdd:cd10046  152 DIII 155
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1604-1765 6.60e-15

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 74.49  E-value: 6.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1604 TGFQDKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTEniGKPRYAETWDFHVSASTFLQFEMSMGCSKPFSN-SH 1680
Cdd:cd10050    3 TQLKDTFNRAPSSS-NWLTVVGGKLSTVCgaVASGTALHFSG--GCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNrNQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1681 SVQLQYSLNNGKDWHLVTEecvpptigcLHYTEssiYTSERFQNwkritVYLPLSTISPRTRFRWIQANYT-VGADSWAI 1759
Cdd:cd10050   80 GVLLEYSVNGGITWNLLME---------IFYDQ---YSKPGFVN-----ILLPPEARGVGTRFRWWQPSHDgLDQNDWAI 142


                 ....*.
gi 27436940 1760 DNVVLA 1765
Cdd:cd10050  143 DNVLIG 148
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2321-2478 7.71e-15

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 74.49  E-value: 7.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2321 TVLEDDFTTLDS-RKWLLHPGGTKMPVCG--STGDALVFiEKASTRYVVSTDVAVNEDSFLQIDFAASCSVTDSC--YAI 2395
Cdd:cd10050    3 TQLKDTFNRAPSsSNWLTVVGGKLSTVCGavASGTALHF-SGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNrnQGV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2396 ELEYSVDLGLSWHPLVRdclptnvecsryhlqriLVSDTFNKWTRITLPLPPYTRSQATRFRWHQPApFD--KQQTWAID 2473
Cdd:cd10050   82 LLEYSVNGGITWNLLME-----------------IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPS-HDglDQNDWAID 143


                 ....*
gi 27436940 2474 NVYIG 2478
Cdd:cd10050  144 NVLIG 148
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2520-2661 1.24e-14

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 74.56  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2520 DNFN-RAPSSQNWLTVNGGKLSTVCGAVASGMALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGClITPNNRNQGVLLEY 2598
Cdd:cd10040    4 DKFDgSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGC-SKPYSNSHSVQLQY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2599 SVNGGITWNLLME---------IFYDQ---YSKPGFVN-----ILLPPDAKEIATRFRWWQPrHDGLDQNDWAIDNVLIS 2661
Cdd:cd10040   83 SLNNGRDWHLVTEecvppaigcLHYTEssvYSSERFQNwkritVYLPPATISPRTRFRWIQP-NYAPGADSWAIDNVVLA 161
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1285-1408 1.46e-14

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 73.36  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1285 DRFAVTRDLTLKPGYVLQFKLNIGCANQfSSTAPVLLQYSHDAGMSWFLVKEGCYPASagkgCEGNsrELSEPTMYHTGD 1364
Cdd:cd10037   31 DFFHLLPVLPSTVTHFAQFSINLGCGSH-QPGNSVSLEFSTNHGRSWSLLHTECLPEL----CAGP--HLPHSTVYSSDN 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 27436940 1365 FEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVppFGLDGVYI 1408
Cdd:cd10037  104 YSGWNRITIPLPNAALTSATRFRWRQTGSVVGSM--WAIDNVYI 145
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 3268-3423 2.04e-14

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 73.56  E-value: 2.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3268 YIKDNFESARVTEANWETIQGGVIGSGCGqlapyAHGDSLYFNGCQI--RQAATKPLDLTRASKIMFVLQIGSMSQTDSC 3345
Cdd:cd08525    1 VLLDTFDTLPDSNENWFFYPGGVVKNDCG-----STDSALVFTENIGgeRYAVTRDLTVNEGYMLQFKINVGCSSTFSSS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3346 NSdlsgphavdkaVLLQYSVNNGITWHVIAQ-----------------HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQP 3408
Cdd:cd08525   76 NS-----------VMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQY 144

                        170
                 ....*....|....*
gi 27436940 3409 RHnGTGHDQWALDHV 3423
Cdd:cd08525  145 GY-TSGVQTWAIDNV 158
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 435-556 2.46e-14

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 73.30  E-value: 2.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  435 GAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMG-----GICDPGNSHENDIILYAKIEGRKEHITL 509
Cdd:cd10045   24 GGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGsksvlGTCPPPDRPGEGVLLHYSCDNGITWKLL 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 27436940  510 DTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd10045  104 EHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALD 150
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1604-1762 3.93e-14

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 72.89  E-value: 3.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1604 TGFQDKFDGSIDLQANWYRIQGGQVDIDC--LSMDTALIFteniGKP--RYAETWDFHVSASTFLQFEMSMG-------C 1672
Cdd:cd10051    2 TFLKERFDSEEISSDQWLSLEGGVTCTDCgvLAEGDALYF----GGSgaRQAVTQDLDLRGAKFVQYWARIGsennmtlC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1673 SKPFSNSHSVQLQYSLNNGKDWHLVTEecvpptigcLHYTEssiYTSERFQnwkriTVYLPLSTISPRTRFRWIQ----A 1748
Cdd:cd10051   78 LRPTCRKEGVLLQYSTDGGISWTLLHE---------LDYQK---YISVRYD-----YITLPENARTNSTRLRWWQpftiS 140

                        170
                 ....*....|....*...
gi 27436940 1749 NYTVGADS----WAIDNV 1762
Cdd:cd10051  141 NGLVVSGTeraqWALDNI 158
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2016-2129 1.44e-13

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 70.66  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2016 NENTIIQFEINVGCSTdSSSADPVRLEFSRDFGATWHLL----LP-LCyhssshvsslcSTEHHPSSTYYAG-TMQGWRR 2089
Cdd:cd10037   42 TVTHFAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLhtecLPeLC-----------AGPHLPHSTVYSSdNYSGWNR 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 27436940 2090 EVVHFGKLHLCGSVRFRWYQGFYPAGSQpvtWAIDNVYIG 2129
Cdd:cd10037  110 ITIPLPNAALTSATRFRWRQTGSVVGSM---WAIDNVYIG 146
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 1102-1219 2.05e-13

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 70.48  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1102 SSGSSLYF--SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesasCNKPDSREEGVLLQYSNNGGIQWHLLAE--------- 1170
Cdd:cd08525   30 STDSALVFteNIGGERYAVTRDLTVNEGYMLQFKINVG-----CSSTFSSSNSVMLEYSTDAGLSWHLVQEeclpsspgc 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940 1171 --------MYFSDFSKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDyDQWAVDDIII 1219
Cdd:cd08525  105 selhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGV-QTWAIDNVYI 160
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1080-1221 6.18e-13

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 69.55  E-value: 6.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1080 ESDWQEVIGGEIvkpEQGCgvISSGSSLYF-SKAGK-RQLVSWDLDTSWVDFVQFYIQIGgesasCNKPDSREEGVLLQY 1157
Cdd:cd10040   13 QANWYRIQGGQV---DIDC--LSMDTALMFtENIGKpRYAETWDFHVSASTFLQFELSMG-----CSKPYSNSHSVQLQY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1158 SNNGGIQWHLLAEMYF------------SDFSKPRF-----VYLELPAAAKTPCTRFRWWQPVFsGEDYDQWAVDDIIIL 1220
Cdd:cd10040   83 SLNNGRDWHLVTEECVppaigclhytesSVYSSERFqnwkrITVYLPPATISPRTRFRWIQPNY-APGADSWAIDNVVLA 161


                 .
gi 27436940 1221 S 1221
Cdd:cd10040  162 S 162
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 422-556 7.53e-13

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 68.61  E-value: 7.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  422 EEFESQPTG--W-DVLGAVIGTECGTIESGLSMVFLKD-GERKLCTPSMDTTGYGNLRFYFvMGGICDPGNSHENDIILY 497
Cdd:cd08524    3 DDFDGYPSPdnWlLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYI-GSGCSTPSYSNQPVLLEY 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940  498 AKIEGRKEHItLDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd08524   82 SVDNGASWHL-LEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAID 139
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 724-863 9.25e-13

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 69.17  E-value: 9.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  724 HNFYSIRGAEVSFGCgvLASGKALVFNKDGRRQLITSFLD--SSQSRFLQFTLRLGsksvlstCRAPDQPGEGVLLHYSY 801
Cdd:cd10040   14 ANWYRIQGGQVDIDC--LSMDTALMFTENIGKPRYAETWDfhVSASTFLQFELSMG-------CSKPYSNSHSVQLQYSL 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940  802 DNGITWKLL-----------EHYSYLS-YHEPRI-----ISVELPGDAKQFGIQFRWWQPYHSSQReDVWAIDEIIMTS 863
Cdd:cd10040   85 NNGRDWHLVteecvppaigcLHYTESSvYSSERFqnwkrITVYLPPATISPRTRFRWIQPNYAPGA-DSWAIDNVVLAS 162
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 226-350 1.53e-12

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 67.90  E-value: 1.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  226 ETGEQCGAIMHGNAVTFCEPyGPRELITTGLNTTTASVLQFS--IGS----GSCRF-SYSDPSIIVLYAKNNSADWIQLE 298
Cdd:cd10045   26 EVGFGCGVLASGKALVFNGD-GRRQLITAPLDSTQSRYLQFTlrLGSksvlGTCPPpDRPGEGVLLHYSCDNGITWKLLE 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27436940  299 KIRAPSNVSTIIHILYLPEDAKGENVQFQWKQEnlRVGEVYEACWALDNILI 350
Cdd:cd10045  105 HYSYDNYHEPRIVSVELPEDARNFGVQFRWWQP--YHSGQNQDVWALDEISM 154
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 1071-1220 2.80e-12

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 67.11  E-value: 2.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1071 SDFENQNGWesdWQEVIGGEIvkpEQGCGVISSGSSLYFSKA-GKRQLVSWDLDTSWVDFVQFYIQIGgesaSCnKPDSR 1149
Cdd:cd10036    9 PLLELNNNI---WSECCGCNV---GEQCGVIMHGNALTFCEPyGPRELITVPLNTTTASVLQFAIGSG----SC-RFSYS 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1150 EEGVLLQYS-NNGGIQWHLLAEMyfsdfSKPRFVY-----LELPAAAKTPCTRFRWWQPVFSGEDYDQ--WAVDDIIIL 1220
Cdd:cd10036   78 DPSIIVSYAvNNTSSDWITLEKI-----RAPSNGStiihiIPLPTDAKQDNVSFRFRQEAPNAGEVYEscWALDNVLII 151
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 3270-3426 4.00e-12

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 66.73  E-value: 4.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3270 KDNFESARVTEAN---WETIQGGVIGSGCGQLApyaHGDSLYFngCQI---RQAATKPLDLTRASKIMFVLQIGsmsqtd 3343
Cdd:cd10036    2 RDDFDSYPLLELNnniWSECCGCNVGEQCGVIM---HGNALTF--CEPygpRELITVPLNTTTASVLQFAIGSG------ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3344 SCNSDLSGPhavdkAVLLQYSVNNG-ITWHVIAqhQPKDFTQAQRVSYNVPL--EARMKGVLLRWWQPRHNGTGHDQ--W 3418
Cdd:cd10036   71 SCRFSYSDP-----SIIVSYAVNNTsSDWITLE--KIRAPSNGSTIIHIIPLptDAKQDNVSFRFRQEAPNAGEVYEscW 143


                 ....*...
gi 27436940 3419 ALDHVEVV 3426
Cdd:cd10036  144 ALDNVLII 151
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 2518-2660 5.09e-12

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 66.34  E-value: 5.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2518 LKDNFNRAPSSQN----WLTVNGGKLSTVCGAVASGMALHFSGGC-SRLLVTVDLNLTNAEFIQFYFMYGClITPNNRNQ 2592
Cdd:cd10036    1 LRDDFDSYPLLELnnniWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 2593 GVLLEYSVNGG-ITWNLLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQ--PRHDGLDQNDWAIDNVLI 2660
Cdd:cd10036   80 SIIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLI 150
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2891-3049 7.10e-12

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 66.38  E-value: 7.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2891 FLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTV-RQAVTQDLDLRGAKFLQYWGRIGSENNMTSchrpi 2969
Cdd:cd10039    1 YEKPAFDYPLNQMSVWLMLSNEGMGKNESCSPTPSAMVFGKSDGdRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS----- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2970 crKEGVLLDYSTDGGITWTLLHEMDYQ---------------KYISVRH--DY-------ILLPEDALTNTTRLRWWQPf 3025
Cdd:cd10039   76 --FAPVLLQYSHDAGLTWSLVREGCYPaspgskgcegssrelREPTVYHtgDYedwtritIPIPRSLAASKTRFRWIQE- 152

                        170       180
                 ....*....|....*....|....
gi 27436940 3026 vISNGIVVsgverAQWALDNILIG 3049
Cdd:cd10039  153 -SSSLKNA-----PPFGLDGVYIS 170
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 2531-2661 1.39e-11

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 65.61  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2531 WLTVNGGKLSTVCGAVASGMALHF--SGGcSRLLVTVDLNLTNAEFIQFYFMYGCLITPNNRNQgVLLEYSVNGGITWNL 2608
Cdd:cd10039   16 WLMLSNEGMGKNESCSPTPSAMVFgkSDG-DRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAP-VLLQYSHDAGLTWSL 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940 2609 LMEIFY------------------------DQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS 2661
Cdd:cd10039   94 VREGCYpaspgskgcegssrelreptvyhtGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDGVYIS 170
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 2169-2314 1.69e-11

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 64.93  E-value: 1.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2169 LKDDFEgQLESDRFLLMSGGKPSRKCGilSSGNNLFFNEDG-LRMLMTRDLDLSHARFVQFFMRLGCGkgVPDpRSQPVL 2247
Cdd:cd10042    2 LEDDFS-TLDSRKWLLHPGGTKMPVCG--STGDALVFIEKAsTRYVVTTDIMVNEDSFLQIDFAASCS--VTD-SCYAIE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2248 LQYSLNGGLSWS----------------LLQEFLFSNSSNVGRYIALEIPLKARSGSTRLRWWQPS--ENGHfysPWVID 2309
Cdd:cd10042   76 LEYSVDLGLSWHpllrdclptnvecssyHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPApfDKQQ---TWAID 152


                 ....*
gi 27436940 2310 QILIG 2314
Cdd:cd10042  153 NVYIG 157
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1451-1597 2.15e-11

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 64.93  E-value: 2.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1451 FDRFEGK--LSPLWYKITGAQVGTGCGTLNDGKSLYFNGPGKREARTVPLDTRNIRLVQFYIQIGsktsgitCIKPRTRN 1528
Cdd:cd10040    3 QDKFDGSvdLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMG-------CSKPYSNS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1529 EGLIVQYSNDNGILWHLLRE------LDFMSFLEPQI-----------ISIDLPQDAKTPATAFRWWQPQHGKHSAQWAL 1591
Cdd:cd10040   76 HSVQLQYSLNNGRDWHLVTEecvppaIGCLHYTESSVysserfqnwkrITVYLPPATISPRTRFRWIQPNYAPGADSWAI 155


                 ....*.
gi 27436940 1592 DDVLIG 1597
Cdd:cd10040  156 DNVVLA 161
Reelin_subrepeat_like cd08524
Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein ...
 3058-3228 2.19e-11

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197341 [Multi-domain]  Cd Length: 144  Bit Score: 64.37  E-value: 2.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3058 LVDTFDdeGTSHEENWSFYPNAvRTAGFCGNPSfhlywpnkkkdkTHNAL------SSRELIIQP-----GYMMQFKIVV 3126
Cdd:cd08524    1 LKDDFD--GYPSPDNWLLCPGG-KTGTVCGALS------------SGNALvfnepyGPRELVTTDlntneASFLQFYIGS 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3127 GCEATSCGDlHSVMLEYTKDArSDSWQLVQTqclpsssnsigcspfqfheatiYNSVNSSSWKRITIQLPDHVSSSATQF 3206
Cdd:cd08524   66 GCSTPSYSN-QPVLLEYSVDN-GASWHLLEE----------------------IRADSFSKWRIIILYLPEDAKSGATRF 121

                        170       180
                 ....*....|....*....|...
gi 27436940 3207 RWIQKGEETEKQS-WAIDHVYIG 3228
Cdd:cd08524  122 RWWQPNHRGVYQAtWAIDNVLIG 144
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 419-556 3.48e-11

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 63.70  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  419 QWSEEFESQPTG--W-DVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGICDPGNSHENDII 495
Cdd:cd10050    4 QLKDTFNRAPSSsnWlTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQGVLL 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940  496 LYAKIEGRKEHITLDtLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd10050   84 EYSVNGGITWNLLME-IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAID 143
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 216-350 3.89e-11

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 63.68  E-value: 3.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  216 PNIWVECNNCETGEQCGAIMHGNAVTFCEPyGPRELITTGLNTTTASVLQFSIGSGS------C-RFSYSDPSIIVLYAK 288
Cdd:cd10047   13 SPLWYKITGGQVGTGCGVIKDGKSLYFNGP-GKREARTVPLDTTNIRLVQFYIQIGSklngetClRPRSRNEGIIVQYSN 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27436940  289 NNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQEnlRVGEvYEACWALDNILI 350
Cdd:cd10047   92 DNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP--QHGK-PSAQWALDDVLI 150
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1607-1764 4.08e-11

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 63.76  E-value: 4.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1607 QDKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTENigKPRYAETWDFHVSASTFLQFEMSMGCSK--PFSNSHSV 1682
Cdd:cd10049    6 KDDFEGQLESD-RFLLMSGGKPSRKCgiLSSGNNLFFNED--GLRMLVTRDLDLSMARFVQFFMRLGCGKgvPDPRSQPV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1683 QLQYSLNNGKDWHLVTEecvpptigcLHYTESSiytserfQNWKRITVYLPLSTISPRTRFRWIQANYTvGA--DSWAID 1760
Cdd:cd10049   83 LLQYSLNGGLTWSLLQE---------FLFSNSS-------NVGRYVALEIPLKARSPSTRLRWWQPSEN-GHfySPWVID 145


                 ....
gi 27436940 1761 NVVL 1764
Cdd:cd10049  146 QILI 149
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 717-862 4.67e-11

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 63.64  E-value: 4.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  717 SSRLSSYHNFYS-IRGAEVSFGCGVLASGKALVF-NKDGRRQLITSFLDSSQSRFLQFTLRLGsksvlsTCR-APDQPGe 793
Cdd:cd10036    8 YPLLELNNNIWSeCCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQFAIGSG------SCRfSYSDPS- 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  794 gvlLHYSYDNGIT---WKLLEHYSYLSYHEPRIISVELPGDAKQFGIQFRWWQ--PYHSSQREDVWAIDEIIMT 862
Cdd:cd10036   81 ---IIVSYAVNNTssdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLII 151
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 928-1030 1.08e-10

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 62.54  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  928 IQFSLVMGCgqKYTPHMDNQ-VKLEYSTNHGLTWHLVQEeclpsmpscqeftsasIYHaSEFTQWRRVIVLLPQKTWSSA 1006
Cdd:cd10050   62 VQFYFMYGC--LIPPSNRNQgVLLEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPPEARGVG 122

                         90       100
                 ....*....|....*....|....*.
gi 27436940 1007 TRFRWSQSYYTA--QDEWALDSIYIG 1030
Cdd:cd10050  123 TRFRWWQPSHDGldQNDWAIDNVLIG 148
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 899-1030 1.11e-10

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 62.56  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  899 TLCFTGDSKlassmRYVETQSMQIGASYMIQFSLVMGCGQK---YTPHMDNQVKLEYSTNHGLTWHLVQEeclpsmpscq 975
Cdd:cd10046   42 SLYFNKDGL-----RQLVSWDLDTTWVDFIQFYIQIGGGSAscnYPDSREEGVLLQYSNNGGISWKLLAE---------- 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940  976 eftsasiYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYYTAQ--DEWALDSIYIG 1030
Cdd:cd10046  107 -------MYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEgyDQWALDDIIIL 156
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 872-1030 1.13e-10

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 62.61  E-value: 1.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  872 DFTNLVEVTQSLGFYLGNVQPYCGHDWT---LCFTGDSklassMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQV 948
Cdd:cd10049    8 DFEGQLESDRFLLMSGGKPSRKCGILSSgnnLFFNEDG-----LRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQPV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  949 KLEYSTNHGLTWHLVQEeclpsmpscQEFTSASiyhasefTQWRRVIVLLPQKTWSSATRFRWSQ-----SYYtaqDEWA 1023
Cdd:cd10049   83 LLQYSLNGGLTWSLLQE---------FLFSNSS-------NVGRYVALEIPLKARSPSTRLRWWQpsengHFY---SPWV 143


                 ....*..
gi 27436940 1024 LDSIYIG 1030
Cdd:cd10049  144 IDQILIG 150
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1954-2129 1.23e-10

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 62.16  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1954 PVMLLDTFDFGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNevGEHSITTRDLNVNENTIIQFEINVGCSTDS 2033
Cdd:cd10050    2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVC-----GAVASGTALHFSGG--CSRQLVTVDLNLTNAEFVQFYFMYGCLIPP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2034 SSADP-VRLEFSRDFGATWHLLLPLCYHSSshvsslcstehhpSSTYYAGTMqgWRREVVHFGklhlcgsVRFRWYQGFY 2112
Cdd:cd10050   75 SNRNQgVLLEYSVNGGITWNLLMEIFYDQY-------------SKPGFVNIL--LPPEARGVG-------TRFRWWQPSH 132

                        170
                 ....*....|....*..
gi 27436940 2113 pAGSQPVTWAIDNVYIG 2129
Cdd:cd10050  133 -DGLDQNDWAIDNVLIG 148
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 882-1027 2.51e-10

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 61.74  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  882 SLGFYLGNVQPYcGHDWTLCFTGdsklaSSMRYVETQSMQIGASYMIQFSLVMG-------CGQKYT-PH-MDNQVKLEY 952
Cdd:cd10052   25 GIGSGCGQLAPH-AHGDSLYFNG-----CGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSsPRaVDKAVLLQY 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27436940  953 STNHGLTWHLVQEeclpsmpscqeftsasiYHASEFTQWRRVIVLLPQKTWSSATRFRWSQSYY--TAQDEWALDSI 1027
Cdd:cd10052   99 SVNNGITWYLIAQ-----------------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdgTGHDQWALDNV 158
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1606-1762 5.40e-10

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 60.96  E-value: 5.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1606 FQDKFDGSIDLQANWYRIQGGQVDIDCLSMD-----TALIFteNIGKPRYAETWDFHVSASTFLQFEMSMG-------C- 1672
Cdd:cd10052    4 IKDNFESGSVSELKWSLIQGGGIGSGCGQLAphahgDSLYF--NGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCn 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1673 ---SKPFSNSHSVQLQYSLNNGKDWHLVTEEcVPPtigclHYTESsiytserfqnwKRITVYLPLSTISPRTRFRWIQAN 1749
Cdd:cd10052   82 inlSSPRAVDKAVLLQYSVNNGITWYLIAQH-QPK-----DFMRA-----------QRVSYNLPLEARTKGVVLRWWQPR 144

                        170
                 ....*....|....
gi 27436940 1750 YT-VGADSWAIDNV 1762
Cdd:cd10052  145 HDgTGHDQWALDNV 158
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 3271-3423 6.74e-10

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 60.69  E-value: 6.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3271 DNFESARVTEANWETIQGGVIGSGCgqlapYAHGDSLYFNG--CQIRQAATKPLDLTRASKIMFVLQIGsmsqtdsCNSD 3348
Cdd:cd10040    4 DKFDGSVDLQANWYRIQGGQVDIDC-----LSMDTALMFTEniGKPRYAETWDFHVSASTFLQFELSMG-------CSKP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3349 LSGPHAVDkavlLQYSVNNGITWHVIAQ-----------------HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPrHN 3411
Cdd:cd10040   72 YSNSHSVQ----LQYSLNNGRDWHLVTEecvppaigclhytessvYSSERFQNWKRITVYLPPATISPRTRFRWIQP-NY 146

                        170
                 ....*....|..
gi 27436940 3412 GTGHDQWALDHV 3423
Cdd:cd10040  147 APGADSWAIDNV 158
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 2892-3048 8.06e-10

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 60.18  E-value: 8.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2892 LKERFDS---EEIKPDLWMSLEGGSTCTECGILAEDTALYFGGST-VRQAVTQDLDLRGAKFLQYwgRIGSennmTSChR 2967
Cdd:cd10036    1 LRDDFDSyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQF--AIGS----GSC-R 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2968 PICRKEGVLLDYSTDGG-ITWTLLHEMDYQKYIS-VRHDyILLPEDALTNTTRLRWWQ--PFVISngivvsgVERAQWAL 3043
Cdd:cd10036   74 FSYSDPSIIVSYAVNNTsSDWITLEKIRAPSNGStIIHI-IPLPTDAKQDNVSFRFRQeaPNAGE-------VYESCWAL 145


                 ....*
gi 27436940 3044 DNILI 3048
Cdd:cd10036  146 DNVLI 150
Reeler pfam02014
Reeler domain;
61-160 8.32e-10

Reeler domain;


Pssm-ID: 460411  Cd Length: 130  Bit Score: 59.29  E-value: 8.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940     61 IAGNPTYYVPGQEYHVTISTSTF---FDGLLVtglytstsvQA-SQSIGGSSAFGFGIMSDHQFGNQFM-CSVVASHVSH 135
Cdd:pfam02014   22 ITVSSTSYRPGETITVTLSGASGgpsFKGFLL---------QArDADSGDPDPVGSFSLPDDADTKFLLdCSGKGNAVTH 92

                           90       100
                   ....*....|....*....|....*...
gi 27436940    136 ---LPTTNLSFIWIAPPAGTGCVNFMAT 160
Cdd:pfam02014   93 sntNKKSSVTVTWTAPASGSGCVVFRAT 120
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1607-1764 1.24e-09

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 59.51  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1607 QDKFDGSI--DLQANWYRIQGGQVDIDCLSMDTALIFTENigKPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSHSVQL 1684
Cdd:cd10048    6 KDDFNGNLrpDLWPEVYGAERGNLNGETIKSGTALIFKGE--GLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1685 QYSLNNGKDWHLVTEECVPPTIGCLHytessiytserfqnwkrITVYLPLSTISPRTRFR-WIQANYTVGADSWAIDNVV 1763
Cdd:cd10048   84 QYSINGGITWHLIDEFYFPTTTDVLF-----------------VNVPLPYTAQTNATRFRlWQPYNSGKKEEVWILDDLV 146


                 .
gi 27436940 1764 L 1764
Cdd:cd10048  147 I 147
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1954-2129 3.87e-09

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 58.25  E-value: 3.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1954 PVMLLDTFDFGP-REDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNevGEHSITTRDLNVNENTIIQFEINVG---- 2028
Cdd:cd10051    1 KTFLKERFDSEEiSSDQWLSLEGGVTCTDC-----GVLAEGDALYFGGS--GARQAVTQDLDLRGAKFVQYWARIGsenn 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2029 ---CSTDSSSADPVRLEFSRDFGATWHLLLPLCYhssshvsslcstEHHPSSTYyagtmqgwrrEVVHFGKLHLCGSVRF 2105
Cdd:cd10051   74 mtlCLRPTCRKEGVLLQYSTDGGISWTLLHELDY------------QKYISVRY----------DYITLPENARTNSTRL 131

                        170       180       190
                 ....*....|....*....|....*....|
gi 27436940 2106 RWYQ------GFYPAGSQPVTWAIDNVYIG 2129
Cdd:cd10051  132 RWWQpftisnGLVVSGTERAQWALDNILIG 161
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1278-1408 4.39e-09

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 57.98  E-value: 4.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1278 IFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSS--TAPVLLQYSHDAGMSWFLVKEGCYPASAGKGcegnsrels 1355
Cdd:cd10049   39 LFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDprSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVG--------- 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27436940 1356 eptMYhtgdfeewtrITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYI 1408
Cdd:cd10049  110 ---RY----------VALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1619-1764 5.65e-09

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 57.50  E-value: 5.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1619 NWYRIQGGQVDIDC--LSMDTALIFTENiGKpRYAETWDFHVSASTFLQFEMSMG-------CSKPFSNSHSVQLQYSLN 1689
Cdd:cd10045   18 NFSSIRGGEVGFGCgvLASGKALVFNGD-GR-RQLITAPLDSTQSRYLQFTLRLGsksvlgtCPPPDRPGEGVLLHYSCD 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27436940 1690 NGKDWHLVTeecvpptigclHYTessiytserFQNWKR---ITVYLPLSTISPRTRFRWIQANYT-VGADSWAIDNVVL 1764
Cdd:cd10045   96 NGITWKLLE-----------HYS---------YDNYHEpriVSVELPEDARNFGVQFRWWQPYHSgQNQDVWALDEISM 154
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 202-351 7.11e-09

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 57.50  E-value: 7.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQLQLNpniWVECNNCETGEQCGAIM---HGNAVTF--CepyGPRELITTGLNTTTASVLQF--SIGS---- 270
Cdd:cd10052    4 IKDNFESGSVSELK---WSLIQGGGIGSGCGQLAphaHGDSLYFngC---GIRQAVTVELDLTRASKIMFvlQIGSrsqt 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  271 GSCRFSYSDPSII---VL--YAKNNSADWiQLEKIRAPSNVSTIIHILY-LPEDAKGENVQFQWKQEnlRVGEVYEACWA 344
Cdd:cd10052   78 DSCNINLSSPRAVdkaVLlqYSVNNGITW-YLIAQHQPKDFMRAQRVSYnLPLEARTKGVVLRWWQP--RHDGTGHDQWA 154


                 ....*..
gi 27436940  345 LDNILII 351
Cdd:cd10052  155 LDNVEVV 161
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 2169-2313 1.03e-08

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 56.71  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2169 LKDDFE----GQLESDRFLLMSGGKPSRKCGILSSGNNLFFNE-DGLRMLMTRDLDLSHARFVQFfmRLGCGKGVPDPRS 2243
Cdd:cd10036    1 LRDDFDsyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQF--AIGSGSCRFSYSD 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940 2244 QPVLLQYSLNGG-LSWSLLQEF-LFSNSSNVGRYIalEIPLKARSGSTRLRWWQPSENG--HFYSPWVIDQILI 2313
Cdd:cd10036   79 PSIIVSYAVNNTsSDWITLEKIrAPSNGSTIIHII--PLPTDAKQDNVSFRFRQEAPNAgeVYESCWALDNVLI 150
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 421-556 1.07e-08

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 56.75  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  421 SEEFE--SQPTGWDVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGI-----CDPGNSHEND 493
Cdd:cd10047    5 FDRFEgkLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKlngetCLRPRSRNEG 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  494 IIL-YAKIEGRKEHiTLDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHnRNVWAVD 556
Cdd:cd10047   85 IIVqYSNDNGITWH-LLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKP-SAQWALD 146
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 894-1030 1.89e-08

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 56.33  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  894 CG---HDWTLCFTGdsklaSSMRYVETQSMQIGASYMIQFSLVMGCGQK----YTPHMDNQ-VKLEYSTNHGLTWHLVQE 965
Cdd:cd10051   30 CGvlaEGDALYFGG-----SGARQAVTQDLDLRGAKFVQYWARIGSENNmtlcLRPTCRKEgVLLQYSTDGGISWTLLHE 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  966 eclpsmpscqeftsasIYHASeFTQWRRVIVLLPQKTWSSATRFRWSQSY---------YTAQDEWALDSIYIG 1030
Cdd:cd10051  105 ----------------LDYQK-YISVRYDYITLPENARTNSTRLRWWQPFtisnglvvsGTERAQWALDNILIG 161
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 202-350 2.12e-08

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 56.00  E-value: 2.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYHQLQLnpniWVECNNCETGEQCGAIMHGNAVTF---CEpygpRELITTGLNTTTASVLQFSIGSGsCRF--S 276
Cdd:cd10050    5 LKDTFNRAPSSSN----WLTVVGGKLSTVCGAVASGTALHFsggCS----RQLVTVDLNLTNAEFVQFYFMYG-CLIppS 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  277 YSDPSIIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQEnlRVGEVYEACWALDNILI 350
Cdd:cd10050   76 NRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQP--SHDGLDQNDWAIDNVLI 147
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2221-2314 2.28e-08

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 55.64  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2221 SHARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLSWSLLQ-EFL--------------FSNSSNVG-RYIALEIPLKA 2284
Cdd:cd10037   42 TVTHFAQFSINLGCGSHQP---GNSVSLEFSTNHGRSWSLLHtECLpelcagphlphstvYSSDNYSGwNRITIPLPNAA 118

                         90       100       110
                 ....*....|....*....|....*....|
gi 27436940 2285 RSGSTRLRWWQPSENGHfySPWVIDQILIG 2314
Cdd:cd10037  119 LTSATRFRWRQTGSVVG--SMWAIDNVYIG 146
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2548-2660 2.36e-08

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 56.08  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2548 SGMALHFSGgcSRLLVTVDLNLTNAEFIQFYFMYGC--LITPNNRNQgVLLEYSVNGGITWNLLME-------------- 2611
Cdd:cd10038   37 TGDSKHASS--ARYVETQSMQIGASYMIQFSLVMGCgqQYTPHMDNQ-VKLEYSTNHGLTWHLVQEeclpgmpscqefts 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 27436940 2612 --IFY-DQYSKPGFVNILLPPDAKEIATRFRWWQPRHDglDQNDWAIDNVLI 2660
Cdd:cd10038  114 gsIYHsSEFTEWRRITLPLPQKTWSSATRFRWSQSYYT--DQDEWALDNIYI 163
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 1606-1764 2.80e-08

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 55.56  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1606 FQDKFDGSIDLQAN---WYRIQGGQVDIDC--LSMDTALIFTENIGkPRYAETWDFHVSASTFLQFEMSMGCSKPFSNSH 1680
Cdd:cd10036    1 LRDDFDSYPLLELNnniWSECCGCNVGEQCgvIMHGNALTFCEPYG-PRELITVPLNTTTASVLQFAIGSGSCRFSYSDP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1681 SVQLQYSLNNGK-DWHLVTEECVPPtigclhYTESSIYtserfqnwkriTVYLPLSTISPRTRFRWIQANYTVGA---DS 1756
Cdd:cd10036   80 SIIVSYAVNNTSsDWITLEKIRAPS------NGSTIIH-----------IIPLPTDAKQDNVSFRFRQEAPNAGEvyeSC 142


                 ....*...
gi 27436940 1757 WAIDNVVL 1764
Cdd:cd10036  143 WALDNVLI 150
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2209-2314 3.20e-08

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 55.69  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2209 GLRMLMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFL---------FSNSSNVG------ 2273
Cdd:cd10038   45 SARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDNQVKLEYSTNHGLTWHLVQEEClpgmpscqeFTSGSIYHssefte 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 27436940 2274 -RYIALEIPLKARSGSTRLRWWQpsenGHFYSP--WVIDQILIG 2314
Cdd:cd10038  125 wRRITLPLPQKTWSSATRFRWSQ----SYYTDQdeWALDNIYIG 164
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2518-2660 3.86e-08

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 55.57  E-value: 3.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2518 LKDNFNRAPSSQNWLTVNGGKLSTVC-----GAVASGMALHFS----GGCSrlLVTVDLNLTNAEFIQFYFMYGClITPN 2588
Cdd:cd10041    2 LLDTFDFGPNESNWLFYPGGNTGLYCpyqskGAPEEDSAMVFVsselGEHS--ITTRDLDVNENTIIQFEINVGC-TTES 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2589 NRNQGVLLEYSVNGGITWNLLM--------------------EIFYDQYSkPGFVN--ILLPPDAKEIATRFRWWQPRHD 2646
Cdd:cd10041   79 SSADPVRLEFSRDFGATWHLLLplcygsssisslcstelhpsSVYYTGTT-QGWRRevILFGKLHLCGSVRFRWYQGFHP 157

                        170
                 ....*....|....*
gi 27436940 2647 -GLDQNDWAIDNVLI 2660
Cdd:cd10041  158 aGSQPVTWAIDNVYI 172
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 2323-2477 7.09e-08

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 54.40  E-value: 7.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2323 LEDDFTT-----LDSRKWLLHPGGTKMPVCG--STGDALVFIEKASTRYVVSTDVAVNEDSFLQIDFAA-SCSVTDSCYA 2394
Cdd:cd10036    1 LRDDFDSyplleLNNNIWSECCGCNVGEQCGviMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSgSCRFSYSDPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2395 IELEYSVDLG-LSWHPLVRDCLPTNVECSrYHLqrilvsdtfnkwtritLPLPPYTRSQATRFRWHQPAPFDKQQ---TW 2470
Cdd:cd10036   81 IIVSYAVNNTsSDWITLEKIRAPSNGSTI-IHI----------------IPLPTDAKQDNVSFRFRQEAPNAGEVyesCW 143


                 ....*..
gi 27436940 2471 AIDNVYI 2477
Cdd:cd10036  144 ALDNVLI 150
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 3296-3425 7.54e-08

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 54.92  E-value: 7.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3296 GQLAPYA-HGDSLYFNG-----CQIRQAATKPLDLTRASKIMFVLQIGsmsqtdsCNSDLSgPHaVDKAVLLQYSVNNGI 3369
Cdd:cd10038   22 GNVQPYCnHDWTLCFTGdskhaSSARYVETQSMQIGASYMIQFSLVMG-------CGQQYT-PH-MDNQVKLEYSTNHGL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940 3370 TWHVI-----------------AQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHngTGHDQWALDHVEV 3425
Cdd:cd10038   93 TWHLVqeeclpgmpscqeftsgSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYY--TDQDEWALDNIYI 163
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 202-350 1.08e-07

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 54.01  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSYhqlQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPyGPRELITTGLNTTTASVLQF--SIGS----GSCRF 275
Cdd:cd10051    4 LKERFDSE---EISSDQWLSLEGGVTCTDCGVLAEGDALYFGGS-GARQAVTQDLDLRGAKFVQYwaRIGSennmTLCLR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  276 SYS-DPSIIVLYAKNNSADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQ-----ENLRVGEVYEACWALDNIL 349
Cdd:cd10051   80 PTCrKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQpftisNGLVVSGTERAQWALDNIL 159


                 .
gi 27436940  350 I 350
Cdd:cd10051  160 I 160
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1953-2129 1.58e-07

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 53.36  E-value: 1.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1953 NPVMLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGapeedSAMVFvsNEVGEHSITTRDLNVNENTIIQFEINVGCS-- 2030
Cdd:cd10049    1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSG-----NNLFF--NEDGLRMLVTRDLDLSMARFVQFFMRLGCGkg 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2031 TDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSHVSSLCSTEHHPSSTyyagtmqgwrrevvhfgklhlCGSVRFRWYQg 2110
Cdd:cd10049   74 VPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKAR---------------------SPSTRLRWWQ- 131

                        170       180
                 ....*....|....*....|.
gi 27436940 2111 fyPA--GSQPVTWAIDNVYIG 2129
Cdd:cd10049  132 --PSenGHFYSPWVIDQILIG 150
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 2169-2314 2.06e-07

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 53.64  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2169 LKDDFEGQLESDRFLLMSGGKPSRKCGILSSG-----NNLFF--NEDGLRMLMTRDLDLSHARFVQFFMRLGCGkgVPDP 2241
Cdd:cd10041    2 LLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGapeedSAMVFvsSELGEHSITTRDLDVNENTIIQFEINVGCT--TESS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2242 RSQPVLLQYSLNGGLSWSLLQEFLFSNSS----------NVGRYIALEIPLKARS----------GSTRLRWWQ----PS 2297
Cdd:cd10041   80 SADPVRLEFSRDFGATWHLLLPLCYGSSSisslcstelhPSSVYYTGTTQGWRREvilfgklhlcGSVRFRWYQgfhpAG 159

                        170
                 ....*....|....*..
gi 27436940 2298 ENGHfysPWVIDQILIG 2314
Cdd:cd10041  160 SQPV---TWAIDNVYIG 173
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1098-1219 3.71e-07

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 52.60  E-value: 3.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1098 CGviSSGSSLYF-SKAGKRQLVSWDLDTSWVDFVQFYIqiggeSASCNKPDSREeGVLLQYSNNGGIQWH---------- 1166
Cdd:cd10042   26 CG--STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDF-----AASCSVTDSCY-AIELEYSVDLGLSWHpllrdclptn 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1167 ------LLAEMYFSD-FSKPRFVYLELPAAAKTPCTRFRWWQPvfSGEDYDQ-WAVDDIII 1219
Cdd:cd10042   98 vecssyHLQRILVSDtFNKWTRVTLPLPHYTRSQATRFRWHQP--APFDKQQtWAIDNVYI 156
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 422-556 4.92e-07

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 52.09  E-value: 4.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  422 EEFESQP-----TGW--DVLGAVIGTECGTIESGLSMVFLK-DGERKLCTPSMDTTGYGNLRFYFVMGGiCDPGNSHEND 493
Cdd:cd10036    3 DDFDSYPllelnNNIwsECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDPSI 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  494 IILYAKIEGRKEHITLDTLSyssykVPSLVSVVIN-----PELQTPATKFCLRQKNHQG--HNRNVWAVD 556
Cdd:cd10036   82 IVSYAVNNTSSDWITLEKIR-----APSNGSTIIHiiplpTDAKQDNVSFRFRQEAPNAgeVYESCWALD 146
Reelin_repeat_4_subrepeat_1 cd10040
N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2906-3049 5.98e-07

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197348  Cd Length: 170  Bit Score: 52.22  E-value: 5.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2906 WMSLEGGSTCTECgiLAEDTALYFGGS--TVRQAVTQDLDLRGAKFLQYwgrigsENNMtSCHRPICRKEGVLLDYSTDG 2983
Cdd:cd10040   16 WYRIQGGQVDIDC--LSMDTALMFTENigKPRYAETWDFHVSASTFLQF------ELSM-GCSKPYSNSHSVQLQYSLNN 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2984 GITWTLLHE---------MDYQK---YISVRHD-----YILLPEDALTNTTRLRWWQPFVisngivvsGVERAQWALDNI 3046
Cdd:cd10040   87 GRDWHLVTEecvppaigcLHYTEssvYSSERFQnwkriTVYLPPATISPRTRFRWIQPNY--------APGADSWAIDNV 158


                 ...
gi 27436940 3047 LIG 3049
Cdd:cd10040  159 VLA 161
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 928-1030 6.15e-07

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 51.81  E-value: 6.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  928 IQFSLVMGCgqKYTPHMDNQVKLEYSTNHGLTWHLVQEECLPSMpscqefTSASIYHaseftqwrrviVLLPQKTWSSAT 1007
Cdd:cd10048   63 IQFSFKFIT--KGTPERSHSVLLQYSINGGITWHLIDEFYFPTT------TDVLFVN-----------VPLPYTAQTNAT 123

                         90       100
                 ....*....|....*....|....*
gi 27436940 1008 RFRWSQSYYTAQDE--WALDSIYIG 1030
Cdd:cd10048  124 RFRLWQPYNSGKKEevWILDDLVID 148
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2975-3049 7.31e-07

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 51.40  E-value: 7.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2975 VLLDYSTDGGITWTLLHE-----------------MDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNgivvsgve 3037
Cdd:cd10037   64 VSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVG-------- 135

                         90
                 ....*....|..
gi 27436940 3038 rAQWALDNILIG 3049
Cdd:cd10037  136 -SMWAIDNVYIG 146
Reelin_subrepeat_Nt cd10036
Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in ...
 1804-1946 7.72e-07

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.


Pssm-ID: 197344  Cd Length: 151  Bit Score: 51.32  E-value: 7.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1804 LKDDFN----GNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKG-EGLRMLISRDLDCTNTMYVQFSLRFIAKSTPERSH 1878
Cdd:cd10036    1 LRDDFDsyplLELNNNIWSECCGCNVGEQCG-VIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 1879 SILLQFSI-SGGITWHLMDEFYFPQTTNILFINVPLPYTAQTNATRFRLWQPYNNGKK--EEIWIVDDFII 1946
Cdd:cd10036   80 SIIVSYAVnNTSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEvyESCWALDNVLI 150
Reelin_subrepeat_1 cd08525
N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an ...
 201-350 1.33e-06

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197342  Cd Length: 161  Bit Score: 50.83  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  201 ILRDDFDSYHQLQLNpniWVECNNCETGEQCGAimHGNAVTFCEPY-GPRELITTGLNTTTASVLQFSIGSGsCRFSYSD 279
Cdd:cd08525    1 VLLDTFDTLPDSNEN---WFFYPGGVVKNDCGS--TDSALVFTENIgGERYAVTRDLTVNEGYMLQFKINVG-CSSTFSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  280 P-SIIVLYAKNNSADWIQLEKIRAPSNVSTIIH-----------------ILYLPEDAKGENVQFQWKQENLRVGEVyea 341
Cdd:cd08525   75 SnSVMLEYSTDAGLSWHLVQEECLPSSPGCSELhpssvyesstfngwkriTIPLPNATLSSATRFRWIQYGYTSGVQ--- 151


                 ....*....
gi 27436940  342 CWALDNILI 350
Cdd:cd08525  152 TWAIDNVYI 160
Reelin_repeat_3_subrepeat_1 cd10039
N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 731-859 1.78e-06

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197347  Cd Length: 170  Bit Score: 50.97  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  731 GAEVSFGCGvlASGKALVFNK-DGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTcRAPdqpgegVLLHYSYDNGITWKL 809
Cdd:cd10039   23 GMGKNESCS--PTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS-FAP------VLLQYSHDAGLTWSL 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  810 LEHYSY---------------LS---------YHEPRIISVELPGDAKQFGIQFRWWQPYHSSQREDVWAIDEI 859
Cdd:cd10039   94 VREGCYpaspgskgcegssreLReptvyhtgdYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDGV 167
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 560-671 2.49e-06

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 50.23  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  560 VLPVLPSTMSHMIQFSINLGCGT---HQPG---NSVSLEFSTNHGRSWSLLhteclpeicagphlphSTVYSSEnYSGWN 633
Cdd:cd10046   54 VSWDLDTTWVDFIQFYIQIGGGSascNYPDsreEGVLLQYSNNGGISWKLL----------------AEMYFSD-FSKPR 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 27436940  634 RITIPLPNAALTRNTRIRWRQtgPILG----NMWAIDNVYIG 671
Cdd:cd10046  117 FVYLELPTAAKTPCTRFRWWQ--PVFSgegyDQWALDDIIIL 156
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1272-1409 2.91e-06

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 49.80  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1272 ATPSAMIFGKsDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAP-------VLLQYSHDAGMSWFLVKEgcypasag 1344
Cdd:cd10045   35 ASGKALVFNG-DGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPpdrpgegVLLHYSCDNGITWKLLEH-------- 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27436940 1345 kgcegnsrelseptmYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYIS 1409
Cdd:cd10045  106 ---------------YSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1954-2128 3.20e-06

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 49.80  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1954 PVMLLDTFDFGPREDNWFFYP--GGNIGLYCPYSSKGapeedSAMVFvsNEVGEHSITTRDLNVNENTIIQFEINVGCST 2031
Cdd:cd10045    1 PGFLSESFNSSRLSSYHNFSSirGGEVGFGCGVLASG-----KALVF--NGDGRRQLITAPLDSTQSRYLQFTLRLGSKS 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2032 DSSSADP-------VRLEFSRDFGATWHLLLPLCYHSSshvsslcsteHHPsstyyagtmqgwRREVVHFGKLHLCGSVR 2104
Cdd:cd10045   74 VLGTCPPpdrpgegVLLHYSCDNGITWKLLEHYSYDNY----------HEP------------RIVSVELPEDARNFGVQ 131

                        170       180
                 ....*....|....*....|....
gi 27436940 2105 FRWYQGFYPAGSQPVtWAIDNVYI 2128
Cdd:cd10045  132 FRWWQPYHSGQNQDV-WALDEISM 154
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 1954-2129 3.97e-06

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 49.43  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1954 PVMLLDTFDfGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFvsNEVGEHSITTRDLNVNENTIIQFEINVGCSTDS 2033
Cdd:cd10047    1 PSEFFDRFE-GKLSPLWYKITGGQVGTGC-----GVIKDGKSLYF--NGPGKREARTVPLDTTNIRLVQFYIQIGSKLNG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2034 SSADPVR-------LEFSRDFGATWHLLLPLCYhsSSHVSSLCSTEHHPSSTYYAGTMqgwrrevvhfgklhlcgsvrFR 2106
Cdd:cd10047   73 ETCLRPRsrnegiiVQYSNDNGITWHLLRELDF--MSYLEPQVISIELPREAKTPATA--------------------FR 130

                        170       180
                 ....*....|....*....|...
gi 27436940 2107 WYQGFYpaGSQPVTWAIDNVYIG 2129
Cdd:cd10047  131 WWQPQH--GKPSAQWALDDVLIG 151
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1469-1597 8.27e-06

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 48.76  E-value: 8.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1469 QVGTGCgtlNDGKSLYFNGPGKREARTVPLDTRNIR-----LVQFYIQIGsktsgitCIKPRT--RNEGLIVQYSNDNGI 1541
Cdd:cd10038   23 NVQPYC---NHDWTLCFTGDSKHASSARYVETQSMQigasyMIQFSLVMG-------CGQQYTphMDNQVKLEYSTNHGL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27436940 1542 LWHLLRE--LDFM----SFLEPQI-----------ISIDLPQDAKTPATAFRWWQPQHGKhSAQWALDDVLIG 1597
Cdd:cd10038   93 TWHLVQEecLPGMpscqEFTSGSIyhsseftewrrITLPLPQKTWSSATRFRWSQSYYTD-QDEWALDNIYIG 164
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 564-671 1.16e-05

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 47.95  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  564 LPSTMSHMIQFSINLGC-GTHQPGNSVSLEFSTNHGRSWSLLHTECLPEicagphlPHSTVYssenysgwnrITIPLPNA 642
Cdd:cd10048   55 LDCTHTLYIQFSFKFITkGTPERSHSVLLQYSINGGITWHLIDEFYFPT-------TTDVLF----------VNVPLPYT 117

                         90       100       110
                 ....*....|....*....|....*....|.
gi 27436940  643 ALTRNTRIR-WR-QTGPILGNMWAIDNVYIG 671
Cdd:cd10048  118 AQTNATRFRlWQpYNSGKKEEVWILDDLVID 148
Reelin_repeat_6_subrepeat_2 cd10050
C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 564-671 1.22e-05

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197358 [Multi-domain]  Cd Length: 148  Bit Score: 47.91  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  564 LPSTMSHMIQFSINLGCGT--HQPGNSVSLEFSTNHGRSWSLLHteclpEIcagphlphstVYSSENYSGWnrITIPLPN 641
Cdd:cd10050   54 LNLTNAEFVQFYFMYGCLIppSNRNQGVLLEYSVNGGITWNLLM-----EI----------FYDQYSKPGF--VNILLPP 116

                         90       100       110
                 ....*....|....*....|....*....|...
gi 27436940  642 AALTRNTRIRWRQ---TGPIlGNMWAIDNVYIG 671
Cdd:cd10050  117 EARGVGTRFRWWQpshDGLD-QNDWAIDNVLIG 148
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 738-859 1.29e-05

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 47.98  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  738 CGVlaSGKALVF-NKDGRRQLITSFLDSSQSRFLQFTLRLGSkSVLSTCRApdqpgegVLLHYSYDNGITWKLL------ 810
Cdd:cd10042   26 CGS--TGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASC-SVTDSCYA-------IELEYSVDLGLSWHPLlrdclp 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  811 EHYSYLSYHEPRI-----------ISVELPGDAKQFGIQFRWWQPYHSSQREDvWAIDEI 859
Cdd:cd10042   96 TNVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT-WAIDNV 154
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 231-350 1.47e-05

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 47.92  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  231 CGAIMHGNAVTFCEPyGPRELITTGLNTTTASVLQFSI----GSGSCRFSYS-DPSIIVLYAKNNSADWIQLEKIRAPSN 305
Cdd:cd10046   34 CGVISSGSSLYFNKD-GLRQLVSWDLDTTWVDFIQFYIqiggGSASCNYPDSrEEGVLLQYSNNGGISWKLLAEMYFSDF 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 27436940  306 VSTIIHILYLPEDAKGENVQFQWKQEnLRVGEVYEAcWALDNILI 350
Cdd:cd10046  113 SKPRFVYLELPTAAKTPCTRFRWWQP-VFSGEGYDQ-WALDDIII 155
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2334-2475 1.59e-05

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 47.87  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2334 KWLLHPGGTKMPVCGS-----TGDALVFiEKASTRYVVSTDVAVNEDSF----LQIdfaASCSVTDSCY----------- 2393
Cdd:cd10052   17 KWSLIQGGGIGSGCGQlaphaHGDSLYF-NGCGIRQAVTVELDLTRASKimfvLQI---GSRSQTDSCNinlsspravdk 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2394 AIELEYSVDLGLSWHpLVRDCLPTNvecsryhlqrilvsdtFNKWTRITLPLPPYTRSQATRFRWHQPAPFDK-QQTWAI 2472
Cdd:cd10052   93 AVLLQYSVNNGITWY-LIAQHQPKD----------------FMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTgHDQWAL 155


                 ...
gi 27436940 2473 DNV 2475
Cdd:cd10052  156 DNV 158
Reelin_repeat_2_subrepeat_2 cd10046
C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 2001-2129 1.60e-05

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197354 [Multi-domain]  Cd Length: 156  Bit Score: 47.54  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2001 NEVGEHSITTRDLNVNENTIIQFEINVG-----CSTDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSHvsslcstehhP 2075
Cdd:cd10046   46 NKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSK----------P 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27436940 2076 SSTYYagtmqgwrrEVVHFGKLHlcgSVRFRWYQGFYpAGSQPVTWAIDNVYIG 2129
Cdd:cd10046  116 RFVYL---------ELPTAAKTP---CTRFRWWQPVF-SGEGYDQWALDDIIIL 156
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 1838-1946 1.65e-05

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 47.99  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1838 SLIFKGE-----GLRMLISRDLDCTNTMYVQFSLRFIA--KSTPERSHSILLQFSISGGITWHLMDEFYFP--------- 1901
Cdd:cd10038   33 TLCFTGDskhasSARYVETQSMQIGASYMIQFSLVMGCgqQYTPHMDNQVKLEYSTNHGLTWHLVQEECLPgmpscqeft 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27436940 1902 --------QTTNILFINVPLPYTAQTNATRFRLWQPYNNGKKEeiWIVDDFII 1946
Cdd:cd10038  113 sgsiyhssEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDE--WALDNIYI 163
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 427-558 1.93e-05

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 47.18  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  427 QPTGW-DVLGAVIGTECG-TIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMggICDPGNSHENDIILYAKIEGRK 504
Cdd:cd10048   14 RPDLWpEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF--ITKGTPERSHSVLLQYSINGGI 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27436940  505 EHITLDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVDFF 558
Cdd:cd10048   92 TWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDL 145
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2213-2314 2.05e-05

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 47.91  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2213 LMTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGL-SWSLLQE--------------FLF-------SNSS 2270
Cdd:cd10044   53 LTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDPRSdHWQLVQTeclpsssnsidcspFQYheasiysSVNS 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 27436940 2271 NVGRYIALEIPLKARSGSTRLRWWQPSENGhFYSPWVIDQILIG 2314
Cdd:cd10044  133 SVWKRVTIQLPDHVSSSATQFRWIQKTEST-EAPSWAIDDVYIG 175
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1284-1406 2.39e-05

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 47.48  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1284 GDRFAVTRDLTLKPGYVLQFKLNIG-------CANQFSSTAP----VLLQYSHDAGMSWFLVKEgcypasagkgcegnsr 1352
Cdd:cd10052   48 GIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSSPRAvdkaVLLQYSVNNGITWYLIAQ---------------- 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 27436940 1353 elseptmYHTGDFEEWTRITIVIPRSLASSKTRFRWIQESSSQKNVPPFGLDGV 1406
Cdd:cd10052  112 -------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 2570-2660 3.07e-05

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 46.78  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2570 TNAEFIQFYFMYGCLI-TPNNrnqGVLLEYSVNGGITWNLLM---------------EIFY--DQYSKPGFVNILLPPDA 2631
Cdd:cd10037   42 TVTHFAQFSINLGCGShQPGN---SVSLEFSTNHGRSWSLLHteclpelcagphlphSTVYssDNYSGWNRITIPLPNAA 118

                         90       100
                 ....*....|....*....|....*....
gi 27436940 2632 KEIATRFRWWQPRhdGLDQNDWAIDNVLI 2660
Cdd:cd10037  119 LTSATRFRWRQTG--SVVGSMWAIDNVYI 145
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 1080-1219 3.26e-05

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 47.09  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1080 ESDWQEVIGGEIVK--PEQGCGVISSGSSLYF--SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesasCNKPDSREEGVLL 1155
Cdd:cd10041   12 ESNWLFYPGGNTGLycPYQSKGAPEEDSAMVFvsSELGEHSITTRDLDVNENTIIQFEINVG-----CTTESSSADPVRL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1156 QYSNNGGIQWHLLAEMYFSDFS---------KPRFVYLE------------LPAAAKTPCTRFRWWQPVF-SGEDYDQWA 1213
Cdd:cd10041   87 EFSRDFGATWHLLLPLCYGSSSisslcstelHPSSVYYTgttqgwrrevilFGKLHLCGSVRFRWYQGFHpAGSQPVTWA 166


                 ....*.
gi 27436940 1214 VDDIII 1219
Cdd:cd10041  167 IDNVYI 172
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 422-556 4.03e-05

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 46.70  E-value: 4.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  422 EEFESQ---PTGWDVL-GAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGG-----ICDPGNSHEN 492
Cdd:cd10051    6 ERFDSEeisSDQWLSLeGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSennmtLCLRPTCRKE 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940  493 DIILYAKIEGRKEHITLDTLSYSSYKVPSLVSVVINPELQTPATKFCLRQ---KNHQ----GHNRNVWAVD 556
Cdd:cd10051   86 GVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQpftISNGlvvsGTERAQWALD 156
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 410-556 5.95e-05

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 46.04  E-value: 5.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  410 DLSTEDIQEQWSEEFESQptgwdVLGAVIGTECGTIESGLSMVFLKDGERKLCTPSMDTTGYGNLRFYFVMGGICDPGNS 489
Cdd:cd10049    3 DFLKDDFEGQLESDRFLL-----MSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDP 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940  490 HENDIILYAKIEGRKEHITLDTLSYS-SYKVPSLVSVVINPELQTPATKFCLRQKNHQGHNRNVWAVD 556
Cdd:cd10049   78 RSQPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVID 145
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 2515-2660 7.39e-05

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 46.37  E-value: 7.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2515 PTQLKDNFNRAP--SSQNW-LTVNGGKLSTVCGAVASGM--ALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPN- 2588
Cdd:cd10044    1 PSSLVETFEDEGtsHDENWeFYPNGVRTDEFCGNPSFHLtwPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSc 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2589 NRNQGVLLEYSVNGGIT-WNLLME---------------IFYDQ--YSKPGF-----VNILLPPDAKEIATRFRWWQpRH 2645
Cdd:cd10044   81 GDLHPVMLEYTTDPRSDhWQLVQTeclpsssnsidcspfQYHEAsiYSSVNSsvwkrVTIQLPDHVSSSATQFRWIQ-KT 159

                        170
                 ....*....|....*
gi 27436940 2646 DGLDQNDWAIDNVLI 2660
Cdd:cd10044  160 ESTEAPSWAIDDVYI 174
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 2190-2314 7.50e-05

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 46.08  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2190 PSRKCGILSSGNNlffnEDGLRM-LMTRDLDLSHARFVQFFMRLGCGKGVPDPRsQPVLLQYSLNGGLSWSLL-QEFLFS 2267
Cdd:cd10043   40 CDSPDGVMICGSH----DDGREVsAVTHDLTPTEGWILQFKISVGCKSSEKSAQ-QPVHVQYSTDFGVSWSYVtPQCLPS 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27436940 2268 NSSNVG--------------RYIALEIPLKARSGSTRLRWWQpsenGHFYSPWVIDQILIG 2314
Cdd:cd10043  115 DPKCGGsvtqpsvffpskgwRRVTIPLPDKLVGRPIRFRFYQ----KASDMQWALDNFYIG 171
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 3269-3423 1.20e-04

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 45.28  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3269 IKDNFESarVTEANWETIQGGVIGSGCGqlapyAHGDSLYF-NGCQIRQAATKPLDLTRASKIMFVLQIgSMSQTDSCns 3347
Cdd:cd10042    2 LEDDFST--LDSRKWLLHPGGTKMPVCG-----STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAA-SCSVTDSC-- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3348 dlsgphavdKAVLLQYSVNNGITWH-VIAQHQPKD----------------FTQAQRVSYNVPLEARMKGVLLRWWQPRH 3410
Cdd:cd10042   72 ---------YAIELEYSVDLGLSWHpLLRDCLPTNvecssyhlqrilvsdtFNKWTRVTLPLPHYTRSQATRFRWHQPAP 142

                        170
                 ....*....|...
gi 27436940 3411 NGTGHdQWALDHV 3423
Cdd:cd10042  143 FDKQQ-TWAIDNV 154
Reelin_repeat_7_subrepeat_2 cd10051
C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 583-671 1.26e-04

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197359  Cd Length: 162  Bit Score: 45.16  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  583 HQPGNSVSLEFSTNHGRSWSLLHteclpeicagpHLPHstvyssENYSGWNRITIPLPNAALTRNTRIRWRQTGPI---L 659
Cdd:cd10051   81 TCRKEGVLLQYSTDGGISWTLLH-----------ELDY------QKYISVRYDYITLPENARTNSTRLRWWQPFTIsngL 143

                         90
                 ....*....|....*...
gi 27436940  660 GNM------WAIDNVYIG 671
Cdd:cd10051  144 VVSgteraqWALDNILIG 161
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2136-2159 1.26e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 41.56  E-value: 1.26e-04
                           10        20
                   ....*....|....*....|....*
gi 27436940   2136 CNGQGSCINGT-KCICDPGYSGPTC 2159
Cdd:pfam07974    2 CSGRGTCVNQCgKCVCDSGYQGATC 26
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 762-859 1.36e-04

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 44.85  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  762 LDSSQSRFLQFTLRLGSKSvlstcrapDQPGEGVLLHYSYDNGITWKLLEH-----------------YSYLSYHEPRII 824
Cdd:cd10037   39 LPSTVTHFAQFSINLGCGS--------HQPGNSVSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRI 110

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 27436940  825 SVELPGDAKQFGIQFRWWQ--PYHSSQredvWAIDEI 859
Cdd:cd10037  111 TIPLPNAALTSATRFRWRQtgSVVGSM----WAIDNV 143
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1129-1220 1.44e-04

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 44.85  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1129 FVQFYIQIG-GESASCNKpdsreegVLLQYSNNGGIQWHLL----------------AEMYFSD-FSKPRFVYLELPAAA 1190
Cdd:cd10037   46 FAQFSINLGcGSHQPGNS-------VSLEFSTNHGRSWSLLhteclpelcagphlphSTVYSSDnYSGWNRITIPLPNAA 118

                         90       100       110
                 ....*....|....*....|....*....|
gi 27436940 1191 KTPCTRFRWWQPvfSGEDYDQWAVDDIIIL 1220
Cdd:cd10037  119 LTSATRFRWRQT--GSVVGSMWAIDNVYIG 146
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 567-671 1.68e-04

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 44.50  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  567 TMSHMIQFSINLGCGTHQP---GNSVSLEFSTNHGRSWSLLhteclpeicagphlpHSTVYSSENYSGwNRITIPLPNAA 643
Cdd:cd10049   57 SMARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLTWSLL---------------QEFLFSNSSNVG-RYVALEIPLKA 120

                         90       100       110
                 ....*....|....*....|....*....|
gi 27436940  644 LTRNTRIRWRQTGPILGNM--WAIDNVYIG 671
Cdd:cd10049  121 RSPSTRLRWWQPSENGHFYspWVIDQILIG 150
Reelin_repeat_2_subrepeat_1 cd10038
N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an ...
 753-859 1.91e-04

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197346  Cd Length: 168  Bit Score: 44.91  E-value: 1.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  753 GRRQLITSFLDSSQSRFLQFTLRLGsksvlstCRAPDQPG--EGVLLHYSYDNGITWKLLEH-----------------Y 813
Cdd:cd10038   45 SARYVETQSMQIGASYMIQFSLVMG-------CGQQYTPHmdNQVKLEYSTNHGLTWHLVQEeclpgmpscqeftsgsiY 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 27436940  814 SYLSYHEPRIISVELPGDAKQFGIQFRWWQPYHSSQreDVWAIDEI 859
Cdd:cd10038  118 HSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQ--DEWALDNI 161
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 1242-1408 1.98e-04

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 44.49  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1242 KPAFDYPMnQMSVWLML--ANEGMVKNETFCAATpsAMIFgKSDGDRFAVTRDLTLKPGYVLQFKLNIGCANQFSSTAPV 1319
Cdd:cd10048    6 KDDFNGNL-RPDLWPEVygAERGNLNGETIKSGT--ALIF-KGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1320 LLQYSHDAGMSWFLVKEGCYPASAgkgcegnsrelsePTMYhtgdfeewtrITIVIPRSLASSKTRFRWIQESSSQKNVP 1399
Cdd:cd10048   82 LLQYSINGGITWHLIDEFYFPTTT-------------DVLF----------VNVPLPYTAQTNATRFRLWQPYNSGKKEE 138


                 ....*....
gi 27436940 1400 PFGLDGVYI 1408
Cdd:cd10048  139 VWILDDLVI 147
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 713-859 2.23e-04

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 44.78  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  713 ESFGSSRLSSYHNFYSirGAEVSFGC-----GVLASGKALVFNKD--GRRQLITSFLDSSQSRFLQFTLRLGsksvlstC 785
Cdd:cd10041    4 DTFDFGPNESNWLFYP--GGNTGLYCpyqskGAPEEDSAMVFVSSelGEHSITTRDLDVNENTIIQFEINVG-------C 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  786 RAPDQPGEGVLLHYSYDNGITWKLLEHYSYLSYHEPRIISVEL-------PGDAKQF--------------GIQFRWWQP 844
Cdd:cd10041   75 TTESSSADPVRLEFSRDFGATWHLLLPLCYGSSSISSLCSTELhpssvyyTGTTQGWrrevilfgklhlcgSVRFRWYQG 154

                        170
                 ....*....|....*.
gi 27436940  845 YHSSQREDV-WAIDEI 859
Cdd:cd10041  155 FHPAGSQPVtWAIDNV 170
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1533-1597 3.28e-04

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 43.69  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1533 VQYSNDNGILWHLLR-----ELDFMSFLePQI-------------ISIDLPQDAKTPATAFRWWQPqHGKHSAQWALDDV 1594
Cdd:cd10037   66 LEFSTNHGRSWSLLHteclpELCAGPHL-PHStvyssdnysgwnrITIPLPNAALTSATRFRWRQT-GSVVGSMWAIDNV 143


                 ...
gi 27436940 1595 LIG 1597
Cdd:cd10037  144 YIG 146
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1803-1946 3.53e-04

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 43.74  E-value: 3.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1803 ILKDDFNGN------LHPdlwpevyGAERGNLNGETiksGTSLIF-KGEGLRMLISRDLDCTNTMYVQFSLRfIAKSTPE 1875
Cdd:cd10042    1 VLEDDFSTLdsrkwlLHP-------GGTKMPVCGST---GDALVFiEKASTRYVVTTDIMVNEDSFLQIDFA-ASCSVTD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1876 RSHSILLQFSISGGITWHLMDEFYFP--------QTTNILF---------INVPLPYTAQTNATRFRLWQPYNNGKKEEi 1938
Cdd:cd10042   70 SCYAIELEYSVDLGLSWHPLLRDCLPtnvecssyHLQRILVsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT- 148


                 ....*...
gi 27436940 1939 WIVDDFII 1946
Cdd:cd10042  149 WAIDNVYI 156
Reelin_repeat_4_subrepeat_2 cd10048
C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an ...
 2743-2853 4.94e-04

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197356 [Multi-domain]  Cd Length: 150  Bit Score: 43.33  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2743 VTHDLTPTEGWIMQFKISVGCK-VSEKiaQNQIHVQYSTDFGVSWnYLVPQCLPADPkcsgsvsQPSVFFptkgwkriTY 2821
Cdd:cd10048   51 VSRDLDCTHTLYIQFSFKFITKgTPER--SHSVLLQYSINGGITW-HLIDEFYFPTT-------TDVLFV--------NV 112

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 27436940 2822 PLPESLVGNPVRFRFYQKYSDMQ----WAIDNFYLG 2853
Cdd:cd10048  113 PLPYTAQTNATRFRLWQPYNSGKkeevWILDDLVID 148
Reelin_repeat_5_subrepeat_2 cd10049
C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 202-350 5.58e-04

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197357 [Multi-domain]  Cd Length: 150  Bit Score: 42.96  E-value: 5.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  202 LRDDFDSyhqlQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPyGPRELITTGLNTTTASVLQFSIGSGsCRFSYSDP- 280
Cdd:cd10049    5 LKDDFEG----QLESDRFLLMSGGKPSRKCGILSSGNNLFFNED-GLRMLVTRDLDLSMARFVQFFMRLG-CGKGVPDPr 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940  281 --SIIVLYAKNNSADWIQLEKI--RAPSNVSTIIhILYLPEDAKGENVQFQWKQENlRVGEVYEAcWALDNILI 350
Cdd:cd10049   79 sqPVLLQYSLNGGLTWSLLQEFlfSNSSNVGRYV-ALEIPLKARSPSTRLRWWQPS-ENGHFYSP-WVIDQILI 149
Reelin_repeat_1_subrepeat_2 cd10045
C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 564-670 8.47e-04

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197353 [Multi-domain]  Cd Length: 155  Bit Score: 42.48  E-value: 8.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  564 LPSTMSHMIQFSINLG----CGT----HQPGNSVSLEFSTNHGRSWSLLHteclpeicagphlphstVYSSENYSGWNRI 635
Cdd:cd10045   55 LDSTQSRYLQFTLRLGsksvLGTcpppDRPGEGVLLHYSCDNGITWKLLE-----------------HYSYDNYHEPRIV 117

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 27436940  636 TIPLPNAALTRNTRIRWRQTGPILGN--MWAIDNVYI 670
Cdd:cd10045  118 SVELPEDARNFGVQFRWWQPYHSGQNqdVWALDEISM 154
Reelin_repeat_3_subrepeat_2 cd10047
C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an ...
 564-671 8.77e-04

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197355  Cd Length: 151  Bit Score: 42.50  E-value: 8.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940  564 LPSTMSHMIQFSINLG-------CGTHQPGN-SVSLEFSTNHGRSWSLLHtECLPEICAGPHLphstvyssenysgwnrI 635
Cdd:cd10047   52 LDTTNIRLVQFYIQIGsklngetCLRPRSRNeGIIVQYSNDNGITWHLLR-ELDFMSYLEPQV----------------I 114

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 27436940  636 TIPLPNAALTRNTRIRWRQtgPILGN---MWAIDNVYIG 671
Cdd:cd10047  115 SIELPREAKTPATAFRWWQ--PQHGKpsaQWALDDVLIG 151
Reelin_repeat_8_subrepeat_2 cd10052
C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1967-2126 8.93e-04

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197360 [Multi-domain]  Cd Length: 161  Bit Score: 42.86  E-value: 8.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1967 EDNWFFYPGGNIGLYC----PYSSkgapeedsAMVFVSNEVGEHSITTRDLNVNENTIIQFEINVG-------CSTDSSS 2035
Cdd:cd10052   15 ELKWSLIQGGGIGSGCgqlaPHAH--------GDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 2036 ADP----VRLEFSRDFGATWHLLlplcyhssshvsslcsTEHHPSStyyagTMQGwRREVVHFGKLHLCGSVRFRWYQGF 2111
Cdd:cd10052   87 PRAvdkaVLLQYSVNNGITWYLI----------------AQHQPKD-----FMRA-QRVSYNLPLEARTKGVVLRWWQPR 144

                        170
                 ....*....|....*
gi 27436940 2112 YpAGSQPVTWAIDNV 2126
Cdd:cd10052  145 H-DGTGHDQWALDNV 158
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1037-1059 9.64e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.87  E-value: 9.64e-04
                           10        20
                   ....*....|....*....|....*
gi 27436940   1037 CSGHGSCDH--GICRCDQGYQGTEC 1059
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 3231-3259 1.04e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 27436940   3231 CPKLCSGHGYCTTGAiCICDESFQGDDCS 3259
Cdd:pfam18720    2 CPLGCSSRGVCVDGQ-CICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1772-1794 1.40e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*
gi 27436940   1772 CSGRGICDA--GRCVCDRGFGGPYC 1794
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
Reelin_repeat_5_subrepeat_1 cd10041
N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an ...
 3271-3374 2.41e-03

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197349  Cd Length: 174  Bit Score: 41.70  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 3271 DNFESARVtEANWETIQGGVIGSGCGQLAPYAHGD--SLYFNGCQIRQAA--TKPLDLTRASKIMFVLQIGsmsqtdsCN 3346
Cdd:cd10041    4 DTFDFGPN-ESNWLFYPGGNTGLYCPYQSKGAPEEdsAMVFVSSELGEHSitTRDLDVNENTIIQFEINVG-------CT 75

                         90       100
                 ....*....|....*....|....*...
gi 27436940 3347 SDLSGPHAVDkavlLQYSVNNGITWHVI 3374
Cdd:cd10041   76 TESSSADPVR----LEFSRDFGATWHLL 99
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 2860-2882 3.04e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.33  E-value: 3.04e-03
                           10        20
                   ....*....|....*....|....*
gi 27436940   2860 CRGHGDCLRE--QCICDPGYSGPNC 2882
Cdd:pfam07974    2 CSGRGTCVNQcgKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 1768-1794 3.39e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 3.39e-03
                           10        20
                   ....*....|....*....|....*..
gi 27436940   1768 CPWMCSGRGICDAGRCVCDRGFGGPYC 1794
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
Reelin_repeat_1_subrepeat_1 cd10037
N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an ...
 1857-1946 4.17e-03

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197345  Cd Length: 146  Bit Score: 40.61  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1857 TNTMYVQFSLRfIAKSTPERSHSILLQFSISGGITWHLMDEFYFPQTT-------NILF----------INVPLPYTAQT 1919
Cdd:cd10037   42 TVTHFAQFSIN-LGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPELCagphlphSTVYssdnysgwnrITIPLPNAALT 120

                         90       100
                 ....*....|....*....|....*..
gi 27436940 1920 NATRFRLWQPYNNGKKEeiWIVDDFII 1946
Cdd:cd10037  121 SATRFRWRQTGSVVGSM--WAIDNVYI 145
Reelin_repeat_6_subrepeat_1 cd10042
N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an ...
 1530-1597 4.77e-03

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197350  Cd Length: 157  Bit Score: 40.66  E-value: 4.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1530 GLIVQYSNDNGILWH-LLRE-----LDFMSFLEPQI-----------ISIDLPQDAKTPATAFRWWQPQHGKHSAQWALD 1592
Cdd:cd10042   73 AIELEYSVDLGLSWHpLLRDclptnVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAID 152


                 ....*
gi 27436940 1593 DVLIG 1597
Cdd:cd10042  153 NVYIG 157
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 3234-3258 5.42e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.94  E-value: 5.42e-03
                           10        20
                   ....*....|....*....|....*.
gi 27436940   3234 LCSGHGYC-TTGAICICDESFQGDDC 3258
Cdd:pfam07974    1 ICSGRGTCvNQCGKCVCDSGYQGATC 26
Reelin_repeat_7_subrepeat_1 cd10043
N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an ...
 1098-1219 5.55e-03

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197351  Cd Length: 171  Bit Score: 40.69  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27436940 1098 CGVISSGSSLYfskagkrqLVSWDLDTSWVDFVQFYIQIGGESAScnkpDSREEGVLLQYSNNGGIQWHLLAEMYFS--- 1174
Cdd:cd10043   49 CGSHDDGREVS--------AVTHDLTPTEGWILQFKISVGCKSSE----KSAQQPVHVQYSTDFGVSWSYVTPQCLPsdp 116

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 27436940 1175 ----DFSKP---------RFVYLELPAAAKTPCTRFRWWQpvfsGEDYDQWAVDDIII 1219
Cdd:cd10043  117 kcggSVTQPsvffpskgwRRVTIPLPDKLVGRPIRFRFYQ----KASDMQWALDNFYI 170
Reelin_repeat_8_subrepeat_1 cd10044
N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an ...
 1534-1597 7.56e-03

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).


Pssm-ID: 197352  Cd Length: 176  Bit Score: 40.21  E-value: 7.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27436940 1534 QYSNDNGILWhllreldfmsflepQIISIDLPQDAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1597
Cdd:cd10044  126 IYSSVNSSVW--------------KRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAIDDVYIG 175
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1406-1440 7.93e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 37.02  E-value: 7.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 27436940   1406 VYISEPC--PSYCSGHGDCISGVCFCDLGYTAAQGTC 1440
Cdd:pfam01683   16 VAPGESCeaDEQCPGGSVCVNGVCQCPPGFTPVNGRC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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