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Conserved domains on  [gi|333609239|ref|NP_848606|]
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putative transmembrane protein INAFM1 [Homo sapiens]

Protein Classification

InaF-motif domain-containing protein( domain architecture ID 10633237)

InaF-motif domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
InaF-motif pfam15018
TRP-interacting helix; This highly conserved motif is thought to be a transmembrane helix that ...
 25-59 4.17e-13

TRP-interacting helix; This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron. InaF is a protein required for TRP calcium channel function in Drosophila. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types. The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.


:

Pssm-ID: 464449  Cd Length: 35  Bit Score: 59.20  E-value: 4.17e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 333609239   25 GRWLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPTR 59
Cdd:pfam15018   1 KKWVRLLTVVAYVLSVSLAAIVLSVYYIFFWDPDM 35
 
Name Accession Description Interval E-value
InaF-motif pfam15018
TRP-interacting helix; This highly conserved motif is thought to be a transmembrane helix that ...
 25-59 4.17e-13

TRP-interacting helix; This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron. InaF is a protein required for TRP calcium channel function in Drosophila. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types. The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.


Pssm-ID: 464449  Cd Length: 35  Bit Score: 59.20  E-value: 4.17e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 333609239   25 GRWLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPTR 59
Cdd:pfam15018   1 KKWVRLLTVVAYVLSVSLAAIVLSVYYIFFWDPDM 35
 
Name Accession Description Interval E-value
InaF-motif pfam15018
TRP-interacting helix; This highly conserved motif is thought to be a transmembrane helix that ...
 25-59 4.17e-13

TRP-interacting helix; This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron. InaF is a protein required for TRP calcium channel function in Drosophila. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types. The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.


Pssm-ID: 464449  Cd Length: 35  Bit Score: 59.20  E-value: 4.17e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 333609239   25 GRWLRLAPVCAYFLCVSLAAVLLAVYYGLIWVPTR 59
Cdd:pfam15018   1 KKWVRLLTVVAYVLSVSLAAIVLSVYYIFFWDPDM 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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