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Conserved domains on  [gi|49574543|ref|NP_848618|]
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zinc finger protein 616 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 3.57e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 3.57e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49574543     7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLG 47
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-707 6.67e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 6.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 266 QKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGksfsqrvhlrlhqtvhtgerpfkcneCGKTFKRSSNLTVHQV 345
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 346 IHAGKKPYKCDVCGK----AFRHRSNLVCHrriHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVF--S 419
Cdd:COG5048  85 THHNNPSDLNSKSLPlsnsKASSSSLSSSS---SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnT 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 420 KRSSLAVHQRIHTGQKTYKcnkcgkvySKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECG 499
Cdd:COG5048 162 PQSNSLHPPLPANSLSKDP--------SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 500 KVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGE-------KPYKCKECGKVFSQCSRLTVHRR--I 570
Cdd:COG5048 234 QLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvN 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 571 HSGE--KPYKCNE--CGKVYSQYSHLVGHRRVHTGEKPYKCH--ECGKAFNQGSTLNRHQRIH-----TGEKPYKC--NQ 637
Cdd:COG5048 314 HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNS 393

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49574543 638 CGNSFSQRVHLRLHQTVHTGDRP--YKCNECGKTFKRSSNLTAHQIIHAGKKPYKCDECGKvFRHSSHLVSH 707
Cdd:COG5048 394 CIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 187-231 7.10e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 7.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 49574543 187 CNECGKAFKASSSLINHQRIHTtekpYKCNECGKAFHRASLLTVH 231
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
731-756 2.73e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   731 SLSKHQRIHSGKKPYKCNECGKSFIC 756
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-726 3.16e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....
gi 49574543   703 HLVSHQRIHTGEKRYKCIECGKAF 726
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 3.57e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 3.57e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49574543     7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLG 47
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
7-61 4.08e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.04  E-value: 4.08e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 49574543      7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLG--ISPKCVIKELPPTE 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGfqVPKPDLISQLEQGE 57
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-46 1.98e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.52  E-value: 1.98e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 49574543   7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFL 46
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-707 6.67e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 6.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 266 QKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGksfsqrvhlrlhqtvhtgerpfkcneCGKTFKRSSNLTVHQV 345
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 346 IHAGKKPYKCDVCGK----AFRHRSNLVCHrriHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVF--S 419
Cdd:COG5048  85 THHNNPSDLNSKSLPlsnsKASSSSLSSSS---SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnT 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 420 KRSSLAVHQRIHTGQKTYKcnkcgkvySKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECG 499
Cdd:COG5048 162 PQSNSLHPPLPANSLSKDP--------SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 500 KVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGE-------KPYKCKECGKVFSQCSRLTVHRR--I 570
Cdd:COG5048 234 QLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvN 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 571 HSGE--KPYKCNE--CGKVYSQYSHLVGHRRVHTGEKPYKCH--ECGKAFNQGSTLNRHQRIH-----TGEKPYKC--NQ 637
Cdd:COG5048 314 HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNS 393

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49574543 638 CGNSFSQRVHLRLHQTVHTGDRP--YKCNECGKTFKRSSNLTAHQIIHAGKKPYKCDECGKvFRHSSHLVSH 707
Cdd:COG5048 394 CIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 187-231 7.10e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 7.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 49574543 187 CNECGKAFKASSSLINHQRIHTtekpYKCNECGKAFHRASLLTVH 231
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
620-644 7.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.92e-04
                          10        20
                  ....*....|....*....|....*
gi 49574543   620 LNRHQRIHTGEKPYKCNQCGNSFSQ 644
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
731-756 2.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   731 SLSKHQRIHSGKKPYKCNECGKSFIC 756
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-726 3.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....
gi 49574543   703 HLVSHQRIHTGEKRYKCIECGKAF 726
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-47 3.57e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 3.57e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 49574543     7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLG 47
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
7-61 4.08e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 93.04  E-value: 4.08e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 49574543      7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFLG--ISPKCVIKELPPTE 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGfqVPKPDLISQLEQGE 57
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-46 1.98e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.52  E-value: 1.98e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 49574543   7 LTFKDVAIEFSQEEWKCLEPVQKALYKDVMLENYRNLVFL 46
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-707 6.67e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 6.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 266 QKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGksfsqrvhlrlhqtvhtgerpfkcneCGKTFKRSSNLTVHQV 345
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 346 IHAGKKPYKCDVCGK----AFRHRSNLVCHrriHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVF--S 419
Cdd:COG5048  85 THHNNPSDLNSKSLPlsnsKASSSSLSSSS---SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnT 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 420 KRSSLAVHQRIHTGQKTYKcnkcgkvySKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECG 499
Cdd:COG5048 162 PQSNSLHPPLPANSLSKDP--------SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 500 KVFSQHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGE-------KPYKCKECGKVFSQCSRLTVHRR--I 570
Cdd:COG5048 234 QLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvN 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 571 HSGE--KPYKCNE--CGKVYSQYSHLVGHRRVHTGEKPYKCH--ECGKAFNQGSTLNRHQRIH-----TGEKPYKC--NQ 637
Cdd:COG5048 314 HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNS 393

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 49574543 638 CGNSFSQRVHLRLHQTVHTGDRP--YKCNECGKTFKRSSNLTAHQIIHAGKKPYKCDECGKvFRHSSHLVSH 707
Cdd:COG5048 394 CIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
350-759 2.63e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 2.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 350 KKPYKCDVCGKAFRHRSNLVCHRRIHSGEKQYKCN--ECGKVFSKRSSLAVHRRIHTVEKP-CKCNECGKVFSKRSSLAV 426
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSdLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 427 HQRIHTGQKTYKCNKCGKVYSKH--SHLAVHWRIHTGEKAYK-CNECGKVFSIHSRLAAhqrihtgekPYKCNECGKVFS 503
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRdpQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHP---------PLPANSLSKDPS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 504 QHSRLAVHRRIHTGEKPYKCKECGKVFSDRSAFARHRRIHTGEKPYKCKECGKVFSQ----CSRLTVHRRIHSGEKPYKC 579
Cdd:COG5048 182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 580 NECG--KVYSQYSHLVGHRRVHTG-EKPYKCHECGKAFNQGSTLNRHQR--IHTGE--KPYKC--NQCGNSFSQRVHLRL 650
Cdd:COG5048 262 RSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 651 HQTVHTGDRPYKCNECGKTFKRSSNLT--------AHQIIHAGKKPYKCDECGKVFRHSSHLVSHQRIHT---GEKRYKC 719
Cdd:COG5048 342 HILLHTSISPAKEKLLNSSSKFSPLLNneppqslqQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHlsfRPYNCKN 421

                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 49574543 720 IECGKAFGRLFSLSKHQRIHSGKKPYKCNECGKSFICRSG 759
Cdd:COG5048 422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
183-644 5.02e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 5.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 183 KTYVCNECGKAFKASSSLINHQRIHTTEKPYKCNECGkafhraslltvhkvvhtrgksyqcdvCGKIFRKNSYFVRHQRS 262
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 263 HTGQKPYICN-ECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGKSFSQR---VHLRLHQTVHTGERPFKCNECGKTFKrSS 338
Cdd:COG5048  86 HHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRdpqLPDLLSISNLRNNPLPGNNSSSVNTP-QS 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 339 NLTVHQVIHAgkkpykcDVCGKAFRHRSNLVCHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRihtvekpckcnecgkvF 418
Cdd:COG5048 165 NSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL----------------E 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 419 SKRSSLAVHQRIHTGQKTYkcNKCGKVYSKHSHLAVHWRIHtgekaYKCNECGKVFSIHSRLAAHQRIHTG-EKPYKCNE 497
Cdd:COG5048 222 NSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQ 294

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 498 CGKVFSQHSRLAVHRR--IHTGE--KPYKCKE--CGKVFSDRSAFARHRRIHTGEKPYKCK--ECGKVFSQCSR-----L 564
Cdd:COG5048 295 CNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqS 374

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 565 TVHRRIHSGEKPYKC--NECGKVYSQYSHLVGHRRVHTGEKPYKCH--ECGKAFNQGSTLNRHQRIHTGEKPYKCNQCGN 640
Cdd:COG5048 375 LQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454


                ....
gi 49574543 641 SFSQ 644
Cdd:COG5048 455 FRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-595 1.05e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 177 SPHIREKTYVCN--ECGKAFKASSSLINHQRIHTTEKPYKCN-ECGKAFHRASLLTVHKVVHTRGKSYQCDVCGKIFRKN 253
Cdd:COG5048  54 RSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 254 SYFVRHQRSHT---GQKPYICNECGKSFSKSSHLAV-HQRIHTGEKPYKCNlcgksfsqrvHLRLHQTVHTGERPFKCNE 329
Cdd:COG5048 134 DPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPpLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENS 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 330 CGKTFKRSSNLTVHQVIHAGKKPYKCDVCGKAFRHRSNLVCHRRIHSgekQYKCNECGKVFSKRSSLAVHRRIHTVEKPc 409
Cdd:COG5048 204 PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSASESPRSSLPTASSQSSSPNESD- 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 410 kcnecgkvFSKRSSLavhqrihtgQKTYKCNKCGKVYSKHSHLAVHWR--IHTGE--KAYKCNE--CGKVFSIHSRLAAH 483
Cdd:COG5048 280 --------SSSEKGF---------SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 484 QRIHTGEKPYKC--NECGKVFSQ--HSRLAVHRRIHTGEKPYKCKE-----CGKVFSDRSAFARHRRIHTGEKP--YKCK 552
Cdd:COG5048 343 ILLHTSISPAKEklLNSSSKFSPllNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 49574543 553 ECGKVFSQCSRLTVHRRIHSgEKPYKCNECGKVYSQYSHLVGH 595
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 293-376 4.37e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 4.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49574543 293 GEKPYKCNL--CGKSFSQRVHLRLHQtvhtgerpfKCNECGKTFKRSSNLTVHQVIHAGKKPYKCDVCGKAFRHRSNLVC 370
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 49574543 371 HRRiHS 376
Cdd:COG5189 417 HRK-HS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 187-231 7.10e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 7.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 49574543 187 CNECGKAFKASSSLINHQRIHTtekpYKCNECGKAFHRASLLTVH 231
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
620-644 7.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.92e-04
                          10        20
                  ....*....|....*....|....*
gi 49574543   620 LNRHQRIHTGEKPYKCNQCGNSFSQ 644
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
283-308 9.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 49574543   283 HLAVHQRIHTGEKPYKCNLCGKSFSQ 308
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
535-560 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   535 AFARHRRIHTGEKPYKCKECGKVFSQ 560
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
731-756 2.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   731 SLSKHQRIHSGKKPYKCNECGKSFIC 756
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-726 3.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....
gi 49574543   703 HLVSHQRIHTGEKRYKCIECGKAF 726
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
479-504 4.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   479 RLAAHQRIHTGEKPYKCNECGKVFSQ 504
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
591-616 4.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   591 HLVGHRRVHTGEKPYKCHECGKAFNQ 616
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 661-683 5.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.61e-03
                          10        20
                  ....*....|....*....|...
gi 49574543   661 YKCNECGKTFKRSSNLTAHQIIH 683
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-531 5.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.70e-03
                          10        20
                  ....*....|....*....|....*
gi 49574543   507 RLAVHRRIHTGEKPYKCKECGKVFS 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   311 HLRLHQTVHTGERPFKCNECGKTFKR 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 689-711 8.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.40e-03
                          10        20
                  ....*....|....*....|...
gi 49574543   689 YKCDECGKVFRHSSHLVSHQRIH 711
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
647-672 8.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 49574543   647 HLRLHQTVHTGDRPYKCNECGKTFKR 672
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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