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Conserved domains on  [gi|31791032|ref|NP_853639|]
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keratin-associated protein 19-2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRTAP pfam11759
Keratin-associated matrix; The major structural proteins of mammalian hair are the hair ...
 3-46 1.26e-05

Keratin-associated matrix; The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.


:

Pssm-ID: 314599  Cd Length: 59  Bit Score: 37.50  E-value: 1.26e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 31791032    3 YGYGCGCGSFCRLGYGCGYE-----GCRYGCGHRGCGDGCCCPSCYRRY 46
Cdd:pfam11759 11 LGYGCGGYGGLGCGYGCGYGlgyggGYGCGSGYGGYGYGCCRPSCYGRY 59
 
Name Accession Description Interval E-value
KRTAP pfam11759
Keratin-associated matrix; The major structural proteins of mammalian hair are the hair ...
 3-46 1.26e-05

Keratin-associated matrix; The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.


Pssm-ID: 314599  Cd Length: 59  Bit Score: 37.50  E-value: 1.26e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 31791032    3 YGYGCGCGSFCRLGYGCGYE-----GCRYGCGHRGCGDGCCCPSCYRRY 46
Cdd:pfam11759 11 LGYGCGGYGGLGCGYGCGYGlgyggGYGCGSGYGGYGYGCCRPSCYGRY 59
 
Name Accession Description Interval E-value
KRTAP pfam11759
Keratin-associated matrix; The major structural proteins of mammalian hair are the hair ...
 3-46 1.26e-05

Keratin-associated matrix; The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.


Pssm-ID: 314599  Cd Length: 59  Bit Score: 37.50  E-value: 1.26e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 31791032    3 YGYGCGCGSFCRLGYGCGYE-----GCRYGCGHRGCGDGCCCPSCYRRY 46
Cdd:pfam11759 11 LGYGCGGYGGLGCGYGCGYGlgyggGYGCGSGYGGYGYGCCRPSCYGRY 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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