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Conserved domains on  [gi|37574614|ref|NP_932076|]
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nucleoside diphosphate kinase homolog 7 isoform b [Homo sapiens]

Protein Classification

NME7 family nucleoside-diphosphate kinase( domain architecture ID 11885871)

NME7 family nucleoside-diphosphate kinase similar to nucleoside diphosphate kinase 7, which plays a major role in the synthesis of nucleoside triphosphates other than ATP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 56-186 3.07e-88

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239878  Cd Length: 131  Bit Score: 260.84  E-value: 3.07e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICE 135
Cdd:cd04415   1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 37574614 136 WKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd04415  81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 202-335 4.16e-84

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239875  Cd Length: 134  Bit Score: 250.24  E-value: 4.16e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 202 NCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNA 281
Cdd:cd04412   1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 37574614 282 TKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd04412  81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
DM10_dom super family cl26962
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 3-55 2.31e-15

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


The actual alignment was detected with superfamily member smart00676:

Pssm-ID: 474875  Cd Length: 104  Bit Score: 70.80  E-value: 2.31e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37574614      3 DVKN----HRTFLKRTKYDN--------LHLEDLFIGNKVNVFSRQLVLIDYgDQYTARQLGSRK 55
Cdd:smart00676  41 DVRNsgilQGTFLRRQRVPKpppddpeyYHASDLNVGTTINVFGRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 56-186 3.07e-88

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 260.84  E-value: 3.07e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICE 135
Cdd:cd04415   1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 37574614 136 WKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd04415  81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 202-335 4.16e-84

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 250.24  E-value: 4.16e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 202 NCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNA 281
Cdd:cd04412   1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 37574614 282 TKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd04412  81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 56-189 2.74e-60

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 189.68  E-value: 2.74e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614     56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614    134 CEWKRLLGPANsgvARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSS 189
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 202-339 5.34e-57

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 181.21  E-value: 5.34e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614    202 NCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvVTEYHDMVTEMYSGPCVAMEIQQNNA 281
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEG-KPFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 37574614    282 TKTFREFCGPADPeiaRHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILD 339
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
56-189 2.51e-56

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 179.60  E-value: 2.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614    56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614   134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSS 189
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDK pfam00334
Nucleoside diphosphate kinase;
204-336 1.34e-42

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 144.17  E-value: 1.34e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvvTE-YHDMVTEMYSGPCVAMEIQQNNAT 282
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG--KPfFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 37574614   283 KTFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 56-187 2.28e-42

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 143.67  E-value: 2.28e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:COG0105   3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 37574614 134 CEWKRLLGPANSgvarTDASE-SIRALFGTDGIRNAAHGPDSFASAAREMELFFP 187
Cdd:COG0105  83 AVVRKLMGATNP----AEAAPgTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 56-189 2.00e-40

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 138.32  E-value: 2.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:PRK00668   2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614  134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSS 189
Cdd:PRK00668  82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 204-336 6.87e-31

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 113.62  E-value: 6.87e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTeYHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:COG0105   5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPF-FGELVEFMTSGPVVAMVLEGENAVA 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 37574614 284 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:COG0105  84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 207-336 5.84e-26

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 100.57  E-value: 5.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  207 IVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKgvvtE---YHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:PRK00668   7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHK----EkpfFGELVEFMTSGPVVVMVLEGENAIA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37574614  284 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PRK00668  83 KVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFS 132
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 3-55 2.31e-15

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 70.80  E-value: 2.31e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37574614      3 DVKN----HRTFLKRTKYDN--------LHLEDLFIGNKVNVFSRQLVLIDYgDQYTARQLGSRK 55
Cdd:smart00676  41 DVRNsgilQGTFLRRQRVPKpppddpeyYHASDLNVGTTINVFGRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 56-186 3.07e-88

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 260.84  E-value: 3.07e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICE 135
Cdd:cd04415   1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 37574614 136 WKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd04415  81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 202-335 4.16e-84

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 250.24  E-value: 4.16e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 202 NCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHDMVTEMYSGPCVAMEIQQNNA 281
Cdd:cd04412   1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 37574614 282 TKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd04412  81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 202-335 1.38e-69

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 213.37  E-value: 1.38e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 202 NCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVvTEYHDMVTEMYSGPCVAMEIQQNNA 281
Cdd:cd00595   1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGR-PFFPDLVQFMSSGPVVAMILEKDNA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 37574614 282 TKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd00595  80 VGEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 56-186 1.20e-68

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 211.06  E-value: 1.20e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAIS--KAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:cd00595   1 ERTLALIKPDAVAegLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 37574614 134 CEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd00595  81 GEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 56-189 2.74e-60

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 189.68  E-value: 2.74e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614     56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614    134 CEWKRLLGPANsgvARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSS 189
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 202-339 5.34e-57

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 181.21  E-value: 5.34e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614    202 NCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvVTEYHDMVTEMYSGPCVAMEIQQNNA 281
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEG-KPFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 37574614    282 TKTFREFCGPADPeiaRHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFKILD 339
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
56-189 2.51e-56

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 179.60  E-value: 2.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614    56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614   134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSS 189
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 56-187 1.71e-49

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 161.84  E-value: 1.71e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAICE 135
Cdd:cd04418   1 ERTLAIIKPDAVHKAEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISY 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 37574614 136 WKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFP 187
Cdd:cd04418  81 WKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 56-186 1.36e-43

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 146.59  E-value: 1.36e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAI-SKAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAIC 134
Cdd:cd04416   1 EYTLALIKPDAVaEKKDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 37574614 135 EWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd04416  81 EWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 56-186 5.33e-43

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 144.92  E-value: 5.33e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:cd04413   1 ERTLVIIKPDGVQRglIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 37574614 134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd04413  81 KTVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDK pfam00334
Nucleoside diphosphate kinase;
204-336 1.34e-42

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 144.17  E-value: 1.34e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvvTE-YHDMVTEMYSGPCVAMEIQQNNAT 282
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG--KPfFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 37574614   283 KTFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 56-187 2.28e-42

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 143.67  E-value: 2.28e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:COG0105   3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAV 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 37574614 134 CEWKRLLGPANSgvarTDASE-SIRALFGTDGIRNAAHGPDSFASAAREMELFFP 187
Cdd:COG0105  83 AVVRKLMGATNP----AEAAPgTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 56-187 1.54e-41

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 141.38  E-value: 1.54e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  56 EKTLALIKPDAIS---KAGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDA 132
Cdd:cd04414   1 QLTLALIKPDAVAhplALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 37574614 133 ICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFFP 187
Cdd:cd04414  81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 56-189 2.00e-40

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 138.32  E-value: 2.00e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:PRK00668   2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614  134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFFPSS 189
Cdd:PRK00668  82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 53-186 2.06e-36

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 129.56  E-value: 2.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   53 SRKEKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRD 130
Cdd:PLN02931  27 SEEERTLAMIKPDGLSGnyTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKE 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 37574614  131 DAICEWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:PLN02931 107 NAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFF 162
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 204-336 6.87e-31

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 113.62  E-value: 6.87e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTeYHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:COG0105   5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPF-FGELVEFMTSGPVVAMVLEGENAVA 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 37574614 284 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:COG0105  84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 204-335 5.26e-30

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 111.02  E-value: 5.26e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTeYHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:cd04413   3 TLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPF-FPELVEFMTSGPVVAMVLEGENAVK 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 37574614 284 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd04413  82 TVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 58-186 8.72e-30

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 110.80  E-value: 8.72e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  58 TLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQS-RPFFNELIQFITTGPIIAMEILRDDAIC 134
Cdd:cd04412   3 TVCIIKPHAVSHglLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGvVPELPAMVDELTSGPCIALEIAGENAVK 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 37574614 135 EWKRLLGPANSGVARTDASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:cd04412  83 TFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 56-186 8.53e-29

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 108.22  E-value: 8.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:PRK14542   2 SRTFIMIKPDGVKNkhVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37574614  134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:PRK14542  82 LHWREVIGATDPKEA---AAGTIRALYAESKEANAVHGSDSDANAALEISFFF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 203-335 7.07e-27

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 103.06  E-value: 7.07e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 203 CTCCIVKPHAVSEGLLgKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvvTEY-HDMVTEMYSGPCVAMEIQQNNA 281
Cdd:cd04416   2 YTLALIKPDAVAEKKD-EILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEE--EDYfEDLVEFMTSGPSLILVLSKENA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 37574614 282 TKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd04416  79 VEEWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 55-186 2.06e-26

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 102.11  E-value: 2.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   55 KEKTLALIKPDAISK--AGEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDA 132
Cdd:PTZ00093   2 SERTFIMVKPDGVQRglVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 37574614  133 ICEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:PTZ00093  82 VKQGRKLLGATNPLES---APGTIRGDFCVDVGRNVIHGSDSVESAKREIALWF 132
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 207-336 5.84e-26

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 100.57  E-value: 5.84e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  207 IVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKgvvtE---YHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:PRK00668   7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHK----EkpfFGELVEFMTSGPVVVMVLEGENAIA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37574614  284 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PRK00668  83 KVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFS 132
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 57-186 5.96e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 98.05  E-value: 5.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   57 KTLALIKPDAISKA--GEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAIC 134
Cdd:PRK14545   5 RTFTMIKPDAVENGhiGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37574614  135 EWKRLLGPANSgvarTDASE-SIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:PRK14545  85 DFRTLIGATNP----ADAAEgTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 55-186 8.97e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 97.58  E-value: 8.97e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   55 KEKTLALIKPDAISKA--GEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDA 132
Cdd:PRK14540   2 KERTFVALKPDAVERKliGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 37574614  133 ICEWKRLLGPANSGVARTDaseSIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:PRK14540  82 ISTVRKMIGKTNPAEAEPG---TIRGDFGLYTPANIIHASDSKESAEREIKLFF 132
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 204-336 2.18e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 93.97  E-value: 2.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYkGVVTEYHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:PRK14542   4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37574614  284 TFREFCGPADPEIARhlrPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PRK14542  83 HWREVIGATDPKEAA---AGTIRALYAESKEANAVHGSDSDANAALEISFFFK 132
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 56-186 2.23e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 93.86  E-value: 2.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISKA--GEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDAI 133
Cdd:PRK14541   2 ERTLTILKPDCVRKQliGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37574614  134 CEWKRLLGPANSGVArtdASESIRALFGTDGIRNAAHGPDSFASAAREMELFF 186
Cdd:PRK14541  82 ADFRTLIGATDPAEA---AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 204-336 1.81e-22

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 91.42  E-value: 1.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvvTEYHD-MVTEMYSGPCVAMEIQQNNAT 282
Cdd:PRK14540   5 TFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKG--KEFYErLINFMTSGRIVAMVIEGENAI 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 37574614  283 KTFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PRK14540  83 STVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFG 133
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 204-335 1.67e-20

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 86.16  E-value: 1.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvVTEYHDMVTEMYSGPCVAMEIQQNNATK 283
Cdd:PRK14541   4 TLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRE-RPFYGELVEFMSSGPCVPMILEKENAVA 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 37574614  284 TFREFCGPADPEIARHlrpGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:PRK14541  83 DFRTLIGATDPAEAAE---GTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 201-335 2.82e-20

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 85.34  E-value: 2.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  201 TNCTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGvVTEYHDMVTEMYSGPCVAMEIQQNN 280
Cdd:PRK14545   3 GNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAE-RPFYGELVEFMSRGPIVAAILEKEN 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 37574614  281 ATKTFREFCGPADPEIARHlrpGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:PRK14545  82 AVEDFRTLIGATNPADAAE---GTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 203-336 4.21e-19

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 82.10  E-value: 4.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 203 CTCCIVKPHAVSEGllGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTEYHdMVTEMYSGPCVAMEIQQNNAT 282
Cdd:cd04418   2 RTLAIIKPDAVHKA--EEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPH-LVAYMSSGPIVAMVLARHNAI 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 37574614 283 KTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:cd04418  79 SYWKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 204-335 7.61e-19

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 81.29  E-value: 7.61e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614 204 TCCIVKPHAVSEGL-LGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVVTeYHDMVTEMYSGPCVAMEIQQNNAT 282
Cdd:cd04414   3 TLALIKPDAVAHPLaLEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFF-YDRLVSFMTSGPSWALILAHENAI 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 37574614 283 KTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFF 335
Cdd:cd04414  82 KTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFF 134
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 204-336 8.00e-17

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 77.16  E-value: 8.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFY----EVYKGVVTE----YHDM------------- 262
Cdd:PRK14544   6 TLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseEWYRSVGNKllkaYQELgidprarlgtddp 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  263 -----------VTEMYSGPCVAMEIQQNNATKTFREFCGPADPEIArhlRPGTLRAIFG----------KTKIQNAVHCT 321
Cdd:PRK14544  86 vevgkkvkeslVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSidspdlaaeeGRVVYNLVHAS 162

                        170
                 ....*....|....*
gi 37574614  322 DLPEDGLLEVQYFFK 336
Cdd:PRK14544 163 DSPEEAEREIKFWFR 177
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 185-336 8.43e-16

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 74.09  E-value: 8.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  185 FFPSSGGCGPANTAKftncTCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVvTEYHDMVT 264
Cdd:PLN02931  17 FPIRCSSSGASEEER----TLAMIKPDGLSGNYTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSR-SFFPSLVK 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 37574614  265 EMYSGPCVAMEIQQNNATKTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PLN02931  92 YMTSGPVLVMVLEKENAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFFG 163
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 56-186 1.73e-15

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 73.69  E-value: 1.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISKA--GEIIEIINKAGFTITKLKMMMLSRKEALDFHVDHQS--------------------------- 106
Cdd:PRK14544   4 ERTLVILKPDAVKRGlvGEIISRFEKAGLKIVAMKMVKATPEQIERFYPSSEEwyrsvgnkllkayqelgidprarlgtd 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  107 ------RPFFNELIQFITTGPIIAMEILRDDAICEWKRLLGP-----ANSGVARTDASESIRALFGTDG--IRNAAHGPD 173
Cdd:PRK14544  84 dpvevgKKVKESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPtsphkAPPGTIRGDYSIDSPDLAAEEGrvVYNLVHASD 163

                        170
                 ....*....|...
gi 37574614  174 SFASAAREMELFF 186
Cdd:PRK14544 164 SPEEAEREIKFWF 176
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 3-55 2.31e-15

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 70.80  E-value: 2.31e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37574614      3 DVKN----HRTFLKRTKYDN--------LHLEDLFIGNKVNVFSRQLVLIDYgDQYTARQLGSRK 55
Cdd:smart00676  41 DVRNsgilQGTFLRRQRVPKpppddpeyYHASDLNVGTTINVFGRQFRIYDC-DEFTRNYLESKG 104
PLN02619 PLN02619
nucleoside-diphosphate kinase
 56-186 2.71e-13

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 68.34  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISKaGEIIEIINK---AGFTITKLKMMMLSRKEALDFHVDHQSRPFFNELIQFITTGPIIAMEILRDDA 132
Cdd:PLN02619  89 ERTFIAIKPDGVQR-GLISEIISRferKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAMVWEGEGV 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 37574614  133 ICEWKRLLG---PANS--GVARTDASESIRalfgtdgiRNAAHGPDSFASAAREMELFF 186
Cdd:PLN02619 168 IKYGRKLIGatdPQKSepGTIRGDLAVVVG--------RNIIHGSDGPETAKDEINLWF 218
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 208-336 9.87e-13

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 64.74  E-value: 9.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  208 VKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYEVYKGVvTEYHDMVTEMYSGPCVAMEIQQNNATKTFRE 287
Cdd:PTZ00093   9 VKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGK-PFFPGLVKYISSGPVVCMVWEGKNVVKQGRK 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 37574614  288 FCGPADPEIARhlrPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PTZ00093  88 LLGATNPLESA---PGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFK 133
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 204-336 1.79e-11

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 61.83  E-value: 1.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  204 TCCIVKPHAVSEGLLGKILMAIRDAGFEISAMQMFNMDRVNVEEFYeVYKGVVTEYHDMVTE-----MYSGPCVAMEIQQ 278
Cdd:PRK14543   8 TLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHY-LYDDIAVRHGEAVWKslikfISSSPVFVFVVEG 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 37574614  279 NNATKTFREFCGPADPEIArhlRPGTLRAIFG----------KTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PRK14543  87 VESVEVVRKFCGSTEPKLA---IPGTIRGDFSyhsfnyanekGFSVYNVIHASANEDDALREIPIWFK 151
PLN02619 PLN02619
nucleoside-diphosphate kinase
 208-336 5.49e-07

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 49.85  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614  208 VKPHAVSEGLLGKILMAIRDAGFEISAMQMFnmdrVNVEEFYEVYkgvvteYHDMVTEMY---------SGPCVAMEIQQ 278
Cdd:PLN02619  95 IKPDGVQRGLISEIISRFERKGFKLVAIKVV----VPSKEFAQKH------YHDLKERPFfnglcdflsSGPVVAMVWEG 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 37574614  279 NNATKTFREFCGPADPEIARhlrPGTLRAIFGKTKIQNAVHCTDLPEDGLLEVQYFFK 336
Cdd:PLN02619 165 EGVIKYGRKLIGATDPQKSE---PGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWFK 219
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 56-186 9.15e-06

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 45.27  E-value: 9.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574614   56 EKTLALIKPDAISKA--GEIIEIINKAGFTITKLKMMMLSRKEAL------DFHVDHqSRPFFNELIQFITTGPIIAMEI 127
Cdd:PRK14543   6 QKTLCIIKPDGVRRGliGNVVSRFERVGLKIVAAKMLLVDRSMAEkhylydDIAVRH-GEAVWKSLIKFISSSPVFVFVV 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 37574614  128 LRDDAICEWKRLLGPANSGVArtdASESIRALFGTD----------GIRNAAHGPDSFASAAREMELFF 186
Cdd:PRK14543  85 EGVESVEVVRKFCGSTEPKLA---IPGTIRGDFSYHsfnyanekgfSVYNVIHASANEDDALREIPIWF 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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