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Conserved domains on  [gi|40548326|ref|NP_954980|]
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developmental pluripotency-associated protein 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGC7_Stella super family cl21352
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 1-144 5.34e-28

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


The actual alignment was detected with superfamily member pfam15549:

Pssm-ID: 464759  Cd Length: 166  Bit Score: 101.92  E-value: 5.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548326     1 MDPSQ-FNPTYIPGSPQMLTEENSRDDSGASQISS-ETLIKNLSNLTINASSESVSPLSEALLRresvgaavLREIEDEW 78
Cdd:pfam15549   1 MDPLQkWDPMLISESSQMATEEDSQAVSAASQPSSsETLVKGLSNLTLNPGPSLPAPLPEGLLQ--------QQMREEKT 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40548326    79 LYSRRGVRTLLSVQREKMA------RLRYMLLGGVRTHERRptnkEPKGVKKESRpFKCPCSFCVSNGWDPS 144
Cdd:pfam15549  73 LQQRRWERTLLSQRKKAFLrhirrrRLDHMAPYPVEREQRI----SPSGDRAQNR-FRCLCRYCQSHRPNIS 139
 
Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 1-144 5.34e-28

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 101.92  E-value: 5.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548326     1 MDPSQ-FNPTYIPGSPQMLTEENSRDDSGASQISS-ETLIKNLSNLTINASSESVSPLSEALLRresvgaavLREIEDEW 78
Cdd:pfam15549   1 MDPLQkWDPMLISESSQMATEEDSQAVSAASQPSSsETLVKGLSNLTLNPGPSLPAPLPEGLLQ--------QQMREEKT 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40548326    79 LYSRRGVRTLLSVQREKMA------RLRYMLLGGVRTHERRptnkEPKGVKKESRpFKCPCSFCVSNGWDPS 144
Cdd:pfam15549  73 LQQRRWERTLLSQRKKAFLrhirrrRLDHMAPYPVEREQRI----SPSGDRAQNR-FRCLCRYCQSHRPNIS 139
 
Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 1-144 5.34e-28

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 101.92  E-value: 5.34e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 40548326     1 MDPSQ-FNPTYIPGSPQMLTEENSRDDSGASQISS-ETLIKNLSNLTINASSESVSPLSEALLRresvgaavLREIEDEW 78
Cdd:pfam15549   1 MDPLQkWDPMLISESSQMATEEDSQAVSAASQPSSsETLVKGLSNLTLNPGPSLPAPLPEGLLQ--------QQMREEKT 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 40548326    79 LYSRRGVRTLLSVQREKMA------RLRYMLLGGVRTHERRptnkEPKGVKKESRpFKCPCSFCVSNGWDPS 144
Cdd:pfam15549  73 LQQRRWERTLLSQRKKAFLrhirrrRLDHMAPYPVEREQRI----SPSGDRAQNR-FRCLCRYCQSHRPNIS 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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