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Conserved domains on  [gi|205804177|sp|O43613|]
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RecName: Full=Orexin/Hypocretin receptor type 1; AltName: Full=Hypocretin receptor type 1; AltName: Full=Orexin receptor type 1; Short=Ox-1-R; Short=Ox1-R; Short=Ox1R

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606955)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-369 0e+00

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


:

Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 507.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  47 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQ 126
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 127 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPeLANRTRLFSVCDERW 206
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVP-LANKTILLTVCDERW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 207 ADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWkrpsdqlgdleqglsgePQPRARAFLAE 286
Cdd:cd15208  160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKW-----------------NKPRKSAVAAE 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 VKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15208  223 EKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLF--TVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFR 300

                 ...
gi 205804177 367 EQF 369
Cdd:cd15208  301 EEF 303
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-369 0e+00

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 507.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  47 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQ 126
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 127 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPeLANRTRLFSVCDERW 206
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVP-LANKTILLTVCDERW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 207 ADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWkrpsdqlgdleqglsgePQPRARAFLAE 286
Cdd:cd15208  160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKW-----------------NKPRKSAVAAE 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 VKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15208  223 EKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLF--TVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFR 300

                 ...
gi 205804177 367 EQF 369
Cdd:cd15208  301 EEF 303
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
63-358 8.33e-57

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 187.50  E-value: 8.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177   63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQaAVMECSSVLPElanrtRLFSVCDERWADDLY-PKIYHSC 218
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrrTPRRAKVLILVIWVLALLLSLPP-LLFGWTLTVPE-----GNVTVCFIDFPEDLSkPVSYTLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFLAEVKQMRARRKTAK 298
Cdd:pfam00001 155 ISVLGFLLPLLVILVCYTLIIRTLR-----------------------------------KSASKQKSSERTQRRRKALK 199
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  299 MLMVVLLVFALCYLPISVLNVLkRVFgmFRQASDREAVYACFTFSHWLVYANSAANPIIY 358
Cdd:pfam00001 200 TLAVVVVVFILCWLPYHIVNLL-DSL--ALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
63-371 4.47e-11

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 63.64  E-value: 4.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVcLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:PHA03087  57 GNIIV-IYVLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILG--IWAVSLAIMVPQAAVMECSSVLPELAnrtrlfsVCDERWADDLYPKIYHSCFF 220
Cdd:PHA03087 135 DRYIAIVHPVKSNKINTVKYGYIVSlvIWIISIIETTPILFVYTTKKDHETLI-------CCMFYNNKTMNWKLFINFEI 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 -IVTYLAPLGLMAMAYFQIFRKLWGRQIPgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKM 299
Cdd:PHA03087 208 nIIGMLIPLTILLYCYSKILITLKGINKS------------------------------------------KKNKKAIKL 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 300 LMVVLLVFALCYLP--ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKA 371
Cdd:PHA03087 246 VLIIVILFVIFWLPfnVSVFVYSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
 
Name Accession Description Interval E-value
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-369 0e+00

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 507.31  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  47 WVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQ 126
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 127 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPeLANRTRLFSVCDERW 206
Cdd:cd15208   81 TVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVP-LANKTILLTVCDERW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 207 ADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWkrpsdqlgdleqglsgePQPRARAFLAE 286
Cdd:cd15208  160 SDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQRKW-----------------NKPRKSAVAAE 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 VKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15208  223 EKQLRSRRKTAKMLIVVVIMFAICYLPVHLLNILRYVFGLF--TVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFR 300

                 ...
gi 205804177 367 EQF 369
Cdd:cd15208  301 EEF 303
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
63-369 1.69e-103

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 308.76  E-value: 1.69e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14993   17 GNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVMECSSvLPELANRTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd14993   97 DRYLAICYPLKARrvSTKRRARIIIVAIWVIAIIIMLPLLVVYELEE-IISSEPGTITIYICTEDWPSPELRKAYNVALF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKML 300
Cdd:cd14993  176 VVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSR---------------------------RILRSKKKVARML 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDrEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14993  229 IVVVVLFALSWLPYYVLSILLDFGPLSSEESD-ENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
63-369 4.51e-86

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 264.10  E-value: 4.51e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15207   17 GNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMEcssVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15207   97 DRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLE---VKEYQFFRGQTVHICVEFWPSDEYRKAYTTSLFVL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpsdqlgdleqglsgePQPRARAflaevkQMRARRKTAKMLMV 302
Cdd:cd15207  174 CYVAPLLIIAVLYVRIGYRLWFKPVPGGGSA----------------------SREAQAA------VSKKKVRVIKMLIV 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 303 VLLVFALCYLPISVLNVLKrVFGMFrQASDREAVYA-CFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15207  226 VVVLFALSWLPLHTVTMLD-DFGNL-SPNQREVLYVyIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
63-362 4.56e-70

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 222.55  E-value: 4.56e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd00637   15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPElanrtrlfSVCDERWADDLYPKIYHSCFF 220
Cdd:cd00637   95 DRYLAIVHPLRYRRrfTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGY--------CCCCLCWPDLTLSKAYTIFLF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflAEVKQMRARRKTAKML 300
Cdd:cd00637  167 VLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNS----------------------------SRRRRRRRERKVTKTL 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavYACFTFSHWLVYANSAANPIIYNFLS 362
Cdd:cd00637  219 LIVVVVFLLCWLPYFILLLLDVFGPDPSPLP-----RILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
63-369 2.41e-62

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 203.22  E-value: 2.41e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15203   17 GNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVSTLTLTAIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFsvCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15203   97 DRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGYF--CTESWPSSSSRLIYTISVLVL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpsdqlgdleqglsgepqpraraflaevKQMRAR-RKTAKMLM 301
Cdd:cd15203  175 QFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRR---------------------------RSELRRkRRTNRLLI 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 302 VVLLVFALCYLPISVLNVLKRVFGMFRQasDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15203  228 AMVVVFAVCWLPLNLFNLLRDFEPLPQI--DGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
63-369 8.15e-60

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 196.43  E-value: 8.15e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15392   17 GNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIaLLILQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVmecSSVLPELANRTRLfSVCDERWADDLYPKIYHSCFFI 221
Cdd:cd15392   97 IDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAIT---SRLFEDSNASCGQ-YICTESWPSDTNRYIYSLVLMI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrPSDQlgdleqglsgepqpraraflaevKQMRARRKTAKMLM 301
Cdd:cd15392  173 LQYFVPLAVLVFTYTRIGIVVWAKRTPGEAEN-------NRDQ-----------------------RMAESKRKLVKMMI 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 302 VVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfsHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15392  223 TVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAA---HWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
63-358 8.33e-57

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 187.50  E-value: 8.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177   63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQaAVMECSSVLPElanrtRLFSVCDERWADDLY-PKIYHSC 218
Cdd:pfam00001  81 IDRYLAIVHPLRYKRrrTPRRAKVLILVIWVLALLLSLPP-LLFGWTLTVPE-----GNVTVCFIDFPEDLSkPVSYTLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFLAEVKQMRARRKTAK 298
Cdd:pfam00001 155 ISVLGFLLPLLVILVCYTLIIRTLR-----------------------------------KSASKQKSSERTQRRRKALK 199
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  299 MLMVVLLVFALCYLPISVLNVLkRVFgmFRQASDREAVYACFTFSHWLVYANSAANPIIY 358
Cdd:pfam00001 200 TLAVVVVVFILCWLPYHIVNLL-DSL--ALDCELSRLLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
63-369 1.77e-56

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 187.62  E-value: 1.77e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15393   17 GNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFsvCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15393   97 DRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNNGVKPF--CLPVGPSDDWWKIYNLYLVCV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpsdqlgdleqglsgepqprarAFLAEVKqmRARRKTAKMLMV 302
Cdd:cd15393  175 QYFVPLVIICYAYTRIAVKIWGTKAPGNAQD----------------------------VRDDEIL--KNKKKVIKMLII 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 303 VLLVFALCYLPISVLNVLKRVfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15393  225 VVALFALCWLPLQTYNLLNEI---KPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
63-369 2.95e-56

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 187.10  E-value: 2.95e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15095   17 GNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCLTLTALSV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPllFKS----TARRARGSILGIWAVSLAIMVPQAAVMEcssVLPELANRTRLFsvCDERWADDLYPKIYHSC 218
Cdd:cd15095   97 DRYYAIVHP--IRSlrfrTPRVAVVVSACIWIVSFLLSIPVAIYYR---LEEGYWYGPQTY--CREVWPSKAFQKAYMIY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsalvrnwkrpsdqlgdleqglsgepqprARAFLAEVKQMRARRKTAK 298
Cdd:cd15095  170 TVLLTYVIPLAIIAVCYGLILRRLWRRSVDGN-----------------------------NQSEQLSERALRQKRKVTR 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdrEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15095  221 MVIVVVVLFAICWLPNHVLNLWQRFDPNFPET---YATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
63-369 8.59e-56

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 186.17  E-value: 8.59e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15202   17 GNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAvmeCSSVLPELANRTRLFSVCDERWAD--DLYPKIYHSCFF 220
Cdd:cd15202   97 DRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAI---CSKLETFKYSEDIVRSLCLEDWPEraDLFWKYYDLALF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpsDQLGDLEQGlsgepqpraraflaevkQMRARRKTAKML 300
Cdd:cd15202  174 ILQYFLPLLVISFAYARVGIKLWASNMPG-------------DATTERYFA-----------------LRRKKKKVIKML 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFgMFRQASDREAVYACFtfsHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15202  224 MVVVVLFALCWLPFNIYVLLLSSK-PDYLIKTINAVYFAF---HWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
63-369 9.04e-55

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 183.26  E-value: 9.04e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15390   17 GNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQ---AAVMECSSVLPElaNRTrlfsVCDERWADDLYPK---IYH 216
Cdd:cd15390   97 DRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQllySTTETYYYYTGS--ERT----VCFIAWPDGPNSLqdfVYN 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSalvrnwkrpsdqlgdleqglsgepqprarafLAEVKQMRARRKT 296
Cdd:cd15390  171 IVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENT-------------------------------PRQLESVRAKRKV 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfsHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15390  220 VKMMIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQIYLAI---YWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
63-369 5.34e-53

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 178.78  E-value: 5.34e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14992   17 GNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQaAVMECSSVLPELANRTRLFsVCDERW-ADDLYPKIYHSCF 219
Cdd:cd14992   97 DRYFAIIHPLKPRHrqSYTTTVIIIITIWVVSLLLAIPQ-LYYATTEVLFSVKNQEKIF-CCQIPPvDNKTYEKVYFLLI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVrnwkrpsdqlgdleqglsgepqpraraflaEVKQMRARRKTAKM 299
Cdd:cd14992  175 FVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEV------------------------------ERKRLKCKRRVIKM 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAcftFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14992  225 LVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKHTLQVYY---FLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
63-369 1.06e-51

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 175.56  E-value: 1.06e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd14997   17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVeTWAREPWLLGEFMCKLVPFVELTVAHASVLTILAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSvlpELANRTRLFSVCDERwADDLYPKIYHSCF 219
Cdd:cd14997   97 FERYYAICHPLQAKYvcTKRRALVIIALIWLLALLTSSPVLFITEFKE---EDFNDGTPVAVCRTP-ADTFWKVAYILST 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGrqipgttsalvrnwkRPSDQLGdleqglsgepqpraRAFLAEVKQMRARRKTAKM 299
Cdd:cd14997  173 IVVFFVVPLAILSGLYSVICRRLVG---------------HPALESR--------------RADAANRHTLRSRRQVVYM 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 300 LMVVLLVFALCYLPIsvlnvlkRVFGMF--------RQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14997  224 LITVVVLFFVCLLPF-------RVVTLWiifapdedLQALGLEGYLNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
63-369 3.23e-49

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 168.41  E-value: 3.23e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14971   17 GNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSvlPELANRTrlfsVCDERWADDLYPKIYHSCFF 220
Cdd:cd14971   97 DRFLAVVYPLRSLHirTPRNALAASGCIWVVSLAVAAPVLALHRLRN--YTPGNRT----VCSEAWPSRAHRRAFALCTF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKML 300
Cdd:cd14971  171 LFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSR----------------------------------RAKRKVTRLV 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14971  217 LVVVVLFAACWGPIHAILLLVA----LGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
63-369 4.16e-49

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 168.91  E-value: 4.16e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15980   17 GNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSS-----VLPELANRTRLFSVCDERWADDLYPKIYHS 217
Cdd:cd15980   97 DRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEeknyrVVLGSQNKTSPVYWCREDWPNQEMRKIYTT 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSdqlgdleqglsgepqpraraflaevkqmRARRKTA 297
Cdd:cd15980  177 VLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVVS----------------------------RKKQKVI 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYaCFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15980  229 KMLLIVALLFILSWLPLWTLMMLSDYANLSPNQLQIINIY-IYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
63-369 1.70e-48

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 167.26  E-value: 1.70e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15205   17 GNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK--STARRArGSILGI-WAVSLAIMVPQAAVMECSSVLPELANRTRLFsvCDERWADDLYPKIYHSCF 219
Cdd:cd15205   97 ERHQGIVHPLKMKwqYTNRRA-FTMLGLvWIVSVIVGSPMLFVQQLEVKYDFLYEKRHVC--CLERWYSPTQQKIYTTFI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpsdqlgdleqglsgepqpraraflAEVKQMRARRKTAKM 299
Cdd:cd15205  174 LVILFLLPLTTMLFLYSRIGYELWIKKRVGDASVLQTIHGI------------------------EMSKISRKKKRAVKM 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLkRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15205  230 MVTVVLLFAVCWAPFHVVHMM-IEYSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
63-369 2.82e-48

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 165.43  E-value: 2.82e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14967   16 GNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd14967   96 DRYLAITRPLRYRQlmTKKRALIMIAAVWVYSLLI-----------SLPPLVGWRDETQPSVVDCECEFTPNKIYVLVSS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsALVRNwkrpsdqlgdleqglsgepqpraraflaevkqmrarRKTAKML 300
Cdd:cd14967  165 VISFFIPLLIMIVLYARIFR------------VARRE------------------------------------LKAAKTL 196
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreavYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14967  197 AIIVGAFLLCWLPFFIIYLVSAFCPPDCVP------PILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
63-369 1.09e-47

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 165.00  E-value: 1.09e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15981   17 GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSASVFTLVAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVM----ECSSVLPELANRTRLFSVCDERWADDLYPKIYHSC 218
Cdd:cd15981   97 ERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLtvtrEEHHFMVDDYNNSYPLYSCWEAWPDTEMRKIYTTV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgTTSALVRNwkrpsdqlgdleqGLSGEPQPRaraflaevKQMRARRKTAK 298
Cdd:cd15981  177 LFSHIYLAPLTLIVIMYARIAFKLF------KSSAPIRG-------------SQGEEEEGR--------RVSKRKIKVIN 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYAcFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15981  230 MLIIVALFFTLSWLPLWTLMLLTDYGHLSEDQLNLVTVYV-FPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
63-369 1.12e-47

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 164.78  E-value: 1.12e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15096   17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRtrlfSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15096   97 DRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAY----SYCTFLTEVGTAAQTFFTSFF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsalvrnwkRPSDqlgdleqglsgepqpraraflaevKQMRARRKTAKML 300
Cdd:cd15096  173 LFSYLIPLTLICVLYMLMLRRLRRQKSPGG---------RRSA------------------------ESQRGKRRVTRLV 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15096  220 VVVVVVFAICWLPIHIILLLKY----YGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
63-366 3.19e-47

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 163.45  E-value: 3.19e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15391   17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTrlfsVCDERWADDLYPKIYHSCF-FI 221
Cdd:cd15391   97 DRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRV----LCGESWPGPDTSRSAYTVFvML 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLWGRQIPGTtsalvrnwkrpSDQLGDleqglsgepqpraraflaeVKQMRARRKTAKMLM 301
Cdd:cd15391  173 LTYIIPLLILTSTYGYVGFRLWNRTAPGN-----------ADKGRD-------------------DMQIKSKRKVIKMLV 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 302 VVLLVFALCYLPISVLNVLKRVFGMFR---QASDREAVYACftfsHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15391  223 FVVLMFGICWLPLHLFNLVQDFSTVFRnmpQHTTRLIYGAC----HWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
63-366 4.35e-47

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 163.28  E-value: 4.35e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15389   17 GNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAvmeCSSVLPELANRTRLFSVCDERWAD--DLYPKIYHSCFF 220
Cdd:cd15389   97 DRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAI---YQKLVEFEYSNERTRSRCLPSFPEpsDLFWKYLDLATF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvrnwkrpsDQLGDL--EQglsgepqpraraflaEVKQMRARRKTAK 298
Cdd:cd15389  174 ILQYVLPLLIIGVAYTRVAKKLWLR-----------------NAIGDVttEQ---------------YVAQRRKKKKTIK 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRvFGMFRQASdreAVYACFtfsHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15389  222 MLMLVVLLFAICWLPLNCYHVLLS-SHPIRSNS---ALFFAF---HWLAMSSTCYNPFIYCWLNDSFR 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
63-369 4.46e-47

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 162.56  E-value: 4.46e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15206   17 GNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVSTFTLVAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVmecsSVLPELANRTRLfsVCDERWADDLYPKIYHSCFF 220
Cdd:cd15206   97 ERYFAICHPLKSRVwqTLSHAYKVIAGIWLLSFLIMSPILVF----SNLIPMSRPGGH--KCREVWPNEIAEQAWYVFLD 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKML 300
Cdd:cd15206  171 LMLLVIPGLVMSVAYGLISWTLL-----------------------------------------------EAKKRVIRML 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAV-YACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15206  204 FVIVVEFFICWTPLYVINTWK----AFDPPSAARYVsSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
63-369 2.21e-46

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 160.52  E-value: 2.21e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15001   16 GNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAISI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMEcssVLPELANRTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15001   96 ERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVLFGQG---LVRYESENGVTVYHCQKAWPSTLYSRLYVVYLA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYfqifrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqMRARRKTA-KM 299
Cdd:cd15001  173 IVIFFIPLIVMTFAY------------------------------------------------------ARDTRKQViKM 198
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRvFGMFrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15001  199 LISVVVLFAVCWGPLLIDNLLVS-FDVI-STLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
63-369 1.39e-42

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 151.65  E-value: 1.39e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15927   17 GNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLL-FKSTA-RRARGSILGIWAVSLAIMVPQAAVmecSSVLPELANRTRLFSVC---DERWaDDLYPKIYHS 217
Cdd:cd15927   97 DRYFAIVNPMRkHRSQAtRRTLVTAASIWIVSILLAIPEAIF---SHVVTFTLTDNQTIQICypyPQEL-GPNYPKIMVL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKLW--GRQIPgttsalvrnwkrpsdqlgdleqglSGEPQpraraflAEVKQMRARRK 295
Cdd:cd15927  173 LRFLVYYLIPLLIIGVFYVLMARHLIrsTRNIG------------------------SGQNQ-------AAQRQIEARKK 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNvLKRVFgmfrqasdreAVYACFTFSHW----------LVYANSAANPIIYNFLSGKF 365
Cdd:cd15927  222 VAKTVLAFVVLFAVCWLPRHVFM-LWFHF----------APNGLVDYNAFwhvlkivgfcLSFINSCVNPVALYLLSGSF 290

                 ....
gi 205804177 366 REQF 369
Cdd:cd15927  291 RRHF 294
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
63-368 8.24e-42

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 149.12  E-value: 8.24e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15394   17 GNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPrGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPqAAVMECSSVLPELAnrtrlFSVCDERWADDLYPKIYHSCFF- 220
Cdd:cd15394   97 VDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALP-AAAHTYYVEFKGLD-----FSICEEFWFGQEKQRLAYACSTl 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKML 300
Cdd:cd15394  171 LITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQAEWDR------------------------------ARRRKTFRLL 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15394  221 VVVVVAFAICWLPLHIFNVIRDIDIDL---IDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGE 285
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
63-369 6.76e-39

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 141.50  E-value: 6.76e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15399   17 GNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLTVIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVlpELANRTRLfSVCDERW--ADDLYPKIYHSCFF 220
Cdd:cd15399   97 DRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVI--EISPDFKI-QACSEKWpnGTLNDGTIYSVSML 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvRNWKRPSDQLGDLEQglsgepqpraraflaevkqmrARRKTAKML 300
Cdd:cd15399  174 LIQYVLPLAIISYAYIRIWTKL-------------KNHVSPGGGNDHYHQ---------------------RRRKTTKML 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfsHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15399  220 VCVVVVFAVSWLPFHAFQLASDIDSKVLDLKEYKLIYTIF---HVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
63-368 4.24e-38

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 139.49  E-value: 4.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15397   17 GNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSILSLVLIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAV--------MECSSVLPELANRtrlfSVCDERWADDLYPKI 214
Cdd:cd15397   97 ERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFhiltdepyKNLSHFFAPLADK----AVCTESWPSEHHKLA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvrnwKRPSDQLGDleqglsgepqpraraflAEVKQMRARR 294
Cdd:cd15397  173 YTTWLLLFQYCLPLLFILVCYLRIYLRLRRR-------------KDMLERRGE-----------------YNRRAGHSKR 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 295 KTAkMLMVVLLVFALCYLPISVLNVLkrvfgmfrQASDREAVYAC-----FTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15397  223 INV-MLVSLVAAFALCWLPLNVFNAI--------ADWNHEAIPHCqhnliFSLCHLAAMASTCVNPIIYGFLNSNFKKE 292
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
63-369 1.48e-37

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 137.81  E-value: 1.48e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14970   17 GNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfKS----TARRARGSILGIWAVSLAIMVPqaaVMECSSVLPELANrtrlFSVCDERWADDlyPKIYH-- 216
Cdd:cd14970   96 DRYLAVVHPV--KSlrfrTPRKAKLVSLCVWALSLVLGLP---VIIFARTLQEEGG----TISCNLQWPDP--PDYWGrv 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 --SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNwkrpsdqlgdleqglsgepqpraraflaevkqmRARR 294
Cdd:cd14970  165 ftIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKR---------------------------------RARR 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14970  212 KVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDP----PETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-313 4.49e-37

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 136.64  E-value: 4.49e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15204   17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMdyYVVRQRSWTHGDVLCAVVNYLRTVSLYVSTNALLVI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAvmecSSVLPELANRTRLFsvCDERWADDLYP--KIYHSC 218
Cdd:cd15204   97 AIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAV----YSKTTPYANQGKIF--CGQIWPVDQQAyyKAYYLF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpsdqlgdleqglsgepQPRARaflaevkqMRARRKTAK 298
Cdd:cd15204  171 LFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGQQTE-----------------------QIRRR--------LRRRRRKVR 219
                        250
                 ....*....|....*
gi 205804177 299 MLMVVLLVFALCYLP 313
Cdd:cd15204  220 LLVVILTAFVLCWAP 234
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
63-369 8.92e-37

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 135.62  E-value: 8.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNH--HMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15098   17 GNSLVITVLARVKpgKRRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAM 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPqAAVMECSSVLPELANRTrlfsVCDERWADDLYPKIYHSC 218
Cdd:cd15098   97 SVDRYIAVVHSRTSSSlrTRRNALLGVLVIWVLSLAMASP-VAVHQDLVHHWTASNQT----FCWENWPEKQQKPVYVVC 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsALVRNWKRPSDqlgdleqglsgepqpraraflaevkqmRARRKTAK 298
Cdd:cd15098  172 TFVFGYLLPLLLITFCYAKVLNHLH---------KKLKNMSKKSE---------------------------RSKKKTAQ 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 299 MLMVVLLVFALCYLPISVLNvLKRVFGMF--RQASdreavYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15098  216 TVLVVVVVFGISWLPHHIIH-LWVEFGDFplTQAS-----FVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 3.65e-36

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 133.90  E-value: 3.65e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd16003   17 GNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIYSMTAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQaAVMECSSVLPelaNRTRLFSVCDERWADDLypkIYHSCFFIV 222
Cdd:cd16003   97 DRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQ-CLYSKTKVMP---GRTLCFVAWPGGPDQHF---TYHIIVIVL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTsalvrnwkrpSDQLGDleqglsgepqpraraflaevkQMRARRKTAKMLMV 302
Cdd:cd16003  170 VYCLPLLVMGITYTIVGITLWGGEIPGDT----------SDKYHE---------------------QLRAKRKVVKMMII 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 303 VLLVFALCYLPISVLNVLKrvfGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd16003  219 VVLTFAICWLPYHIYFIVT---GLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
63-369 3.78e-36

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 134.43  E-value: 3.78e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14986   17 GNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMecssVLPELANRTRLfsvCDERWADDLYPKIYHSCFFIV 222
Cdd:cd14986   97 DRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPQLVIF----VERELGDGVHQ---CWSSFYTPWQRKVYITWLATY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTsalvrnwkRPSDQLGDLEQGLSGEPQPRAraflaevKQMRARRKTAKMLMV 302
Cdd:cd14986  170 VFVIPLIILSYCYGRILRTIWIRSRQKTD--------RPIAPTAMSCRSVSCVSSRVS-------LISRAKIKTIKMTLV 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 303 VLLVFALCYLPISVLNvLKRVFGMFRQasDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14986  235 IILAFILCWTPYFIVQ-LLDVYAGMQQ--LENDAY---VVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
63-369 7.27e-36

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 132.48  E-value: 7.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15067   16 GNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTASILNLCVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTrLFSvcderwaDDLYPKIYHSCf 219
Cdd:cd15067   96 LDRYWAITDPISYPSrmTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQC-LFT-------DDSGYLIFSSC- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 fiVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflAEVKQmrarRKTAKM 299
Cdd:cd15067  167 --VSFYIPLVVMLFTYYRIYR--------------------------------------------AAAKE----QKAAKT 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15067  197 LGIVMGVFILCWLPFFVTNILI-GFCPSNCVSNPDILFPLVT---WLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-364 8.75e-35

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 130.62  E-value: 8.75e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15197   17 GNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPqaavmecSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15197   97 DRYDAICHPMNFSQSGRQARVLICVAWILSALFSIP-------MLIIFEKTGLSNGEVQCWILWPEPWYWKVYMTIVAFL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnWKRPSDQLGDLEQGLSGEPQPRA--RAFLAevkqmRARRKTAKML 300
Cdd:cd15197  170 VFFIPATIISICYIIIVRTI---------------WKKSKIQVTINKAGLHDGSSRRSssRGIIP-----RAKIKTIKMT 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGK 364
Cdd:cd15197  230 FVIVTVFIICWSPYFVFDLLD-VFGLLPRSKTKIAAA---TFIQSLAPLNSAINPLIYCLFSTH 289
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
63-369 1.69e-34

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 129.68  E-value: 1.69e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFgHAlCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14968   17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLPTNF-HG-CLFMACLVLVLTQSSIFSLLAIAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPqaaVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHScf 219
Cdd:cd14968   95 DRYLAIKIPLRYKSlvTGRRAWGAIAVCWVLSFLVgLTP---MFGWNNGAPLESGCGEGGIQCLFEEVIPMDYMVYFN-- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNwkrpsdqlgDLEQGLSGEPQPRARAFLaevkqmRARRKTAKM 299
Cdd:cd14968  170 FFACVLVPLLIMLVIYLRIFR-------------VIRK---------QLRQIESLLRSRRSRSTL------QKEVKAAKS 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGMFRqaSDREAVYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 369
Cdd:cd14968  222 LAIILFLFALCWLPLHIINCITLFCPECK--VPKILTYIAILLSH----ANSAVNPIVYAYRIRKFRQTF 285
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
63-369 1.25e-33

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 127.29  E-value: 1.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15978   17 GNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTFNLVAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVmecSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15978   97 ERYSAICKPLKSRvwQTKSHALKVIAATWCLSFTIMLPYPIY---SNLVPFTRINNSTGNMCRLLWPNDVTQQSWYIFLL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYfqifrklwgrqipGTTSAlvrnwkrpsdqlgDLEQGlsgepqpraraflaeVKQMRARRKTAKML 300
Cdd:cd15978  174 LILFLIPGIVMMTAY-------------GLISL-------------ELYRG---------------IKFLMAKKRVIRML 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLkRVFGmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15978  213 IVIVILFFLCWTPIFSANAW-RAFD--TRSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
60-369 1.06e-32

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 125.16  E-value: 1.06e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  60 ALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLS 138
Cdd:cd14979   14 GIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWwQYPWAFGDGGCKLYYFLFEACTYATVLTIV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 139 FIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYH 216
Cdd:cd14979   94 ALSVERYVAICHPLKAKTlvTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSAVCTLVVDRSTFKYVFQ 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIvTYLAPLGLMAMAYFQIFRKLWGRQIpgttsalvrnwkrpsdqlgdleQGLSGEPQPRARAFLAEVKQmrARRKT 296
Cdd:cd14979  174 VSTFI-FFVLPMFVISILYFRIGVKLRSMRN----------------------IKKGTRAQGTRNVELSLSQQ--ARRQV 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKRVFGMFrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14979  229 VKMLGAVVIAFFVCWLPFHAQRLMFSYASKE-DTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
63-369 6.69e-32

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 122.23  E-value: 6.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15979   17 GNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTFSLVAIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVMecSSVLPELANRTRLfSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15979   97 ERYSAICNPLQSRvwQTRSHAYRVIAATWLLSGLIMIPYPVYS--VTVPVPVGDRPRG-HQCRHAWPSAQVRQAWYVLLL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKML 300
Cdd:cd15979  174 LILFFIPGVVMIVAYGLISRELY--------------------------------------------RGLLAKKRVIRML 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVY-ACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15979  210 VVIVAMFFLCWLPIFSANTWR----AFDPLSAHRALSgAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 6.88e-32

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 122.75  E-value: 6.88e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15125   17 GNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSI--LGIWAVSLAIMVPQAAVMECSSVLPeLANRTrlFSVC-DERWADDLYPKIYHSCF 219
Cdd:cd15125   97 DRYKAIVNPMDIQTSSAVLRTCLkaIAIWVVSVLLAVPEAVFSEVAHIMP-DDNTT--FTACiPYPQTDEMHPKIHSVLI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLW--GRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflaevKQMRARRKTA 297
Cdd:cd15125  174 FLVYFLIPLAIISIYYYHIAKTLIksAHNIPGEYSEHSK-------------------------------RQMETRKRLA 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLnVLKRVFGmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15125  223 KIVLVFVGLFAFCWFPNHVL-YMYRSFN-YNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
63-367 3.01e-31

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 121.09  E-value: 3.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15396   17 GNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECS-SVLPELANRTRLFS---VCDERWADDLYPKIYHSC 218
Cdd:cd15396   97 ERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQLTdEPFRNLSSHSDFYKdkvVCIEAWPSETERLIFTTS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQipGTTSALVRNWKRPSDQlgdleqglsgepqpraraflaevkqmrarRKTAK 298
Cdd:cd15396  177 LLVFQYFVPLGFIFICYLKIFVCLKKRN--SKIDRMRENESRLSEN-----------------------------KRINT 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 299 MLMVVLLVFALCYLPISVLNVlkrVFGMfrqasDREAVYAC-----FTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15396  226 MLISIVVTFAACWLPLNIFNV---VFDW-----NHEVLMSChhnlvFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
63-369 3.27e-31

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 120.80  E-value: 3.27e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15123   17 GNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKST--ARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTrlFSVCDERWADDLYPKIYHSCF- 219
Cdd:cd15123   97 DRYRAIVKPLELQTSdaVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTT--FEACAPYPVSEKILQEIHSLLc 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWgrqipgtTSALvrnwkrpsdqlgdleqGLSGEPQPRARaflaevKQMRARRKTAKM 299
Cdd:cd15123  175 FLVFYIIPLSIISVYYFLIARTLY-------KSTF----------------NMPAEEHSHAR------KQIESRKRVAKT 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 300 LMVVLLVFALCYLPISVLnVLKRVFgMFRQASDREAVYACFT-FSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15123  226 VLVLVALFAFCWLPNHIL-YLYRSF-TYHTSVDSSAFHLIATiFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 5.34e-31

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 120.33  E-value: 5.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd16004   17 GNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIYSMTAIAA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQaavmeCSSVLPELANRTrlfSVCDERWADDLYPK---IYHSCF 219
Cdd:cd16004   97 DRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQ-----CFYSTVTMDQGR---TKCIVAWPGDSGGKhqlTYHLAV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGtTSALVRNwkrpsdqlgdleqglsgepqpraraflaeVKQMRARRKTAKM 299
Cdd:cd16004  169 IVLIYLLPLAVMFVTYSIIGITLWRSAVPG-HQAHGAY-----------------------------HRQLQAKKKFVKT 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVY-ACFtfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd16004  219 MVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYlAIF----WLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
63-369 6.71e-31

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 119.41  E-value: 6.71e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtaicLPASLLVDITES------WLFGHALCKVIPYLQAVSVSVAVLT 136
Cdd:cd14995   17 GNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMV----LVAAGLPNEIESllgpdsWIYGYAGCLLITYLQYLGINASSLS 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 137 LSFIALDRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQAAVMEcssvLPELANRTRLFSVCDERWADDLYPKI 214
Cdd:cd14995   93 ITAFTIERYIAICHPMkaQFICTVSRAKKIICFVWIFTSLYCSPWLFLLD----LSIKHYGDDIVVRCGYKVSRHYYLPI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVtYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARR 294
Cdd:cd14995  169 YLADFVLF-YVIPLLLAIVLYGLIGRILF-----------------------------------------------SSRK 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDREAVYacFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14995  201 QVTKMLAVVVVLFALLWMPYRTL----VVYNSFASPPYLDLWF--LLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
63-369 8.80e-31

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 119.74  E-value: 8.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15051   17 GNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLP-ELANRTRLFSVCDERWADDlypkiyhsCF 219
Cdd:cd15051   97 DRYLAITAPLRYPSrvTPRRVAIALAAIWVVSLAV-----------SFLPiHLGWNTPDGRVQNGDTPNQ--------CR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 F-----------IVTYLAPLGLMAMAYFQIFR--KLWGRQIPGTTSALvrnwkrpsdqlgdleqglsgEPQPRARAFLAE 286
Cdd:cd15051  158 FelnppyvllvaIGTFYLPLLIMCGVYLRIFRiaREQAKRINALTPAS--------------------TANSSKSAATAR 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 vkqmraRRKTAKMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15051  218 ------EHKATVTLAAVLGAFIICWFPYFTYFTYRG----LCGDNINETALSVVL---WLGYANSALNPILYAFLNRDFR 284

                 ...
gi 205804177 367 EQF 369
Cdd:cd15051  285 RAF 287
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
63-366 1.41e-30

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 119.15  E-value: 1.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15395   17 GNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLVLIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVP----QAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSC 218
Cdd:cd15395   97 ERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPflifQVLTDEPFKNVNVSLDAYKGKYVCLDQFPSDTIRLSYTTC 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGDLEQGlsgepqpRARAflAEVKQMRArrktak 298
Cdd:cd15395  177 LLVLQYFGPLCFIFICYLKIYIRL----------------KRRNNMMDKMRDN-------KYRS--SETKRINI------ 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 299 MLMVVLLVFALCYLPISVLNVlkrVFGMfrqasDREAVYAC-----FTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15395  226 MLISIVVAFAVCWLPLNIFNA---VFDW-----NHEAIATCnhnllFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
63-369 2.70e-30

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 118.00  E-value: 2.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHM-RTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15097   17 GNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMEcssvLPELANRTrlfsVCDERWADDLYpKIYHSCF 219
Cdd:cd15097   97 VDRYLAIRYPLRSRElrTPRNAVAAIALIWGLSLLFAGPYLSYYD----LIDYANST----VCMPGWEEARR-KAMDTCT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkRPSDQLGDLEQglsgepqpraraflaevkQMRARRKTAKM 299
Cdd:cd15097  168 FAFGYLIPVLVVSLSYTRTIKYLW----------------TAVDPLEAMSE------------------SKRAKRKVTKM 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLnVLKRVFGMFrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15097  214 IIIVTALFCLCWLPHHVV-ILCYLYGDF---PFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
63-369 2.86e-30

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 117.45  E-value: 2.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15053   17 GNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGkWYLGPILCDIYIAMDVMCSTASIFNLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaavmecssVLPELAN-RTRLFSVCdeRWADDLYpKIYHSc 218
Cdd:cd15053   97 IDRYIAVTQPIKYarQKNSKRVLLTIAIVWVVSAAIACP---------LLFGLNNvPYRDPEEC--RFYNPDF-IIYSS- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 ffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAK 298
Cdd:cd15053  164 --ISSFYIPCIVMLLLYYRIFRAL------------------------------------------------RREKKATK 193
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVfGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15053  194 TLAIVLGVFLFCWLPFFTLNILNAI-CPKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 7.51e-30

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 116.89  E-value: 7.51e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd16002   17 GNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVmecsSVLPELANRTrlfsVCDERWAD---DLYPKIYHSCF 219
Cdd:cd16002   97 DRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYY----SDTEEMPGRV----VCYVEWPEheeRKYETVYHVCV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTsalvrnwkrpSDQLGDleqglsgepqpraraflaevkQMRARRKTAKM 299
Cdd:cd16002  169 TVLIYFLPLLVIGCAYTVVGITLWASEIPGDS----------SDRYHE---------------------QVSAKRKVVKM 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd16002  218 MIVVVCTFAICWLPYHIYFLLQYFHPELYEQKFIQQVYLAIM---WLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
63-369 1.28e-29

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 116.76  E-value: 1.28e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMR-TVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGhALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15057   17 GNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDIMCSTASILNLCVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTR-------LFSVCDERWADDLYP 212
Cdd:cd15057   96 VDRYWAISSPFRYERrmTRRRAFIMIAVAWTLSALI-----------SFIPVQLGWHRaddtseaLALYADPCQCDSSLN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 213 KIYHSCFFIVTYLAPLGLMAMAYFQIFRkLWGRQIpgttsalvrnwkrpsDQLGDLEQGLSGEPQPRARAFLAevkqMRA 292
Cdd:cd15057  165 RTYAISSSLISFYIPVAIMIVTYTRIYR-IARRQI---------------RRIAALERAAQESTNPDSSLRSS----LRR 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 293 RRKTAKMLMVVLLVFALCYLPISVLNVLKRvFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFlSGKFREQF 369
Cdd:cd15057  225 ETKALKTLSIIMGVFVCCWLPFFILNCVLP-FCDLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
63-369 1.69e-29

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 116.15  E-value: 1.69e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14969   17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLL-FKSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPELanrtrLFSVCDERWADDLYPKI-YHSCFF 220
Cdd:cd14969   97 ERYLVIVRPLKaFRLSKRRALILIAFIWLYGLFWALP--PLFGWSSYVPEG-----GGTSCSVDWYSKDPNSLsYIVSLF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSALVRNWKRpsdqlgdleqglsgepqpraraflaeVKQMRARRKTAKML 300
Cdd:cd14969  170 VFCFFLPLAIIIFCYYKIYRTL--RKMSKRAARRKNSAIT--------------------------KRTKKAEKKVAKMV 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 301 MVVLLVFALCYLPISVLNVLkRVFGMFRQASDREAVYAcftfshwLVYANSAA--NPIIYNFLSGKFREQF 369
Cdd:cd14969  222 LVMIVAFLIAWTPYAVVSLY-VSFGGESTIPPLLATIP-------ALFAKSSTiyNPIIYVFMNKQFRRAL 284
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
63-358 2.65e-29

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 115.61  E-value: 2.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15384   17 GNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITVLISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVM-ECSSVLPELANRTRLFSVCDERWADDLYpkiyhSCF-F 220
Cdd:cd15384   97 DRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFhVERGPFVEDFHQCVTYGFYTAEWQEQLY-----NMLsL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGDLEQGLSGEPQPRARAFLaevkqmRARRKTAKML 300
Cdd:cd15384  172 VFMFPIPLVIMVTCYVLIFITL----------------SKSSRDFQGLEIYTRNRGPNRQRLFH------KAKVKSLRMS 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYacFTFShwlvYANSAANPIIY 358
Cdd:cd15384  230 AVIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVI--FFFG----MSNSCVNPLIY 281
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
63-369 5.54e-29

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 114.83  E-value: 5.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14977   17 GNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRAR--GSILGIWAVSLAIMVPQAavmecssVLPELANRTRL----FSVC---DERWADDLYPK 213
Cdd:cd14977   97 DRYRAAVNSMPMQTIGACLStcVKLAVIWVGSVLLAVPEA-------VLSTVARESSLdnssLTVCimkPSTPFAETYPK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaLVRNWKRPSDQLGDleqglsgepqpraraflaevkQMRAR 293
Cdd:cd14977  170 ARSWWLFGCYFCLPLAFTAVCYLLMART------------LIRAAKEYTRGTKK---------------------HMKQR 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 294 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14977  217 RQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 6.42e-29

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 114.48  E-value: 6.42e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15093   17 GNSLVIYVVLRYAKMKTVTNIYILNLAIADELFM-LGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFCLTVMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfKST----ARRARGSILGIWAVSLAIMVPQAavmecssVLPELANRTRLFSVCDERWADDlyPKIYHSC 218
Cdd:cd15093   96 DRYLAVVHPI--KSArwrrPRVAKVVNLAVWVASLLVILPVV-------VFAGTRENQDGSSACNMQWPEP--AAAWSAG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVT----YLAPLGLMAMAYFQIFRKLwgrqipgTTSALVRNWKRpsdqlgdleqglsgepqpraraflaevkQMRARR 294
Cdd:cd15093  165 FIIYTfvlgFLLPLLIICLCYLLIVIKV-------KSAGLRAGWQQ----------------------------RKRSER 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15093  210 KVTRMVVMVVVVFVICWLPFYVLQLVN----VFVQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
63-369 1.57e-28

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 113.13  E-value: 1.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd14982   17 GNILALWVFLRKMKKRSPTTIYMINLALADLLFV-LTLPFRIYYYLNGGwWPFGDFLCRLTGLLFYINMYGSILFLTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPqaAVMECSSVLPELANRTrlfsvCDERWADDL-YPKIYHSC 218
Cdd:cd14982   96 VDRYLAVVHPLKSRRlrRKRYAVGVCAGVWILVLVASVP--LLLLRSTIAKENNSTT-----CFEFLSEWLaSAAPIVLI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGDLEQglsgepqpraraflaevkqmraRRKTAK 298
Cdd:cd14982  169 ALVVGFLIPLLIILVCYSLIIRAL----------------RRRSKQSQKSVR----------------------KRKALR 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 299 MLMVVLLVFALCYLPisvLNVLKRVFGMFRQA-----SDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14982  211 MILIVLAVFLVCFLP---YHVTRILYLLVRLSfiadcSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
63-367 2.31e-28

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 112.54  E-value: 2.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15012   16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVL-PELANRTRLFsvCDERWADDLypKIYHSCF 219
Cdd:cd15012   96 ERYIAILHPLRCKQllTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILvTQDGQEEEIC--VLDREMFNS--KLYDTIN 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkQMRARRKTAKM 299
Cdd:cd15012  172 FIVWYLIPLLIMTVLYSKISIVLWKSS------------------------------------------SIEARRKVVRL 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFshWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15012  210 LVAVVVSFALCNLPYHARKMWQYWSEPYRCDSNWNALLTPLTF--LVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
77-369 2.49e-28

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 113.07  E-value: 2.49e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  77 MRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 156
Cdd:cd15124   31 MRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 TARRARGSILG--IWAVSLAIMVPQAAVMECSSVLPELANRTrLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMA 234
Cdd:cd15124  111 SNALMKICLKAalIWILSMLLAIPEAVFSDLHPFYDKSTNKT-FVSCAPYPHSNELHPKIHSMASFLIFYVIPLSIISVY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 235 YFQIFRKLwgrqipgTTSALvrnwkrpsdqlgdleqGLSGEPQPRARaflaevKQMRARRKTAKMLMVVLLVFALCYLPI 314
Cdd:cd15124  190 YYFIAKNL-------IRSAY----------------NLPVEGNVHVR------RQIESRKRLAKTVLVFVGLFAFCWLPN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 315 SVLnVLKRVFgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15124  241 HII-YLYRSY-HYSEVDTSMLHFVSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
63-369 2.62e-28

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 113.17  E-value: 2.62e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15048   17 GNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMEC---SSVLPElanrtrlfSVCDERWADDLYPKIYHS 217
Cdd:cd15048   97 DRYLSVTKAVKYRAkqTKRRTVLLMALVWILAFLLYGPAIIGWDLwtgYSIVPT--------GDCEVEFFDHFYFTFITS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 cffIVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvRNWKRPSDqlgdleQGLSGEPQPRARAFLAEVKQMRARRKTA 297
Cdd:cd15048  169 ---VLEFFIPFISVSFFNLLIYLNIRKRS---------RRRPLRSV------PILPASQNPSRARSQREQVKLRRDRKAA 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15048  231 KSLAILVLVFLICWAPYTILTI------IRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
63-366 1.07e-27

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 111.04  E-value: 1.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLvTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15928   17 GNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLYrLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCF 219
Cdd:cd15928   96 VERYLAICHPLRAKVlvTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNVSSGLLSVMLWVSTSF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVtylaPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflaevkQMRARRKTAKM 299
Cdd:cd15928  176 FFV----PMVCLSLLYGLIGRALWDRRQRSRTAGASR--------------------------------RDNNHRQTVRM 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVlnvlKRVFGMFRQASDREAVY---ACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15928  220 LAVIVLAFVLCWLPFHV----GRVIFNHSRASTKHLHYvsqYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
63-369 1.46e-27

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 111.04  E-value: 1.46e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15056   17 GNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAIC-HPLLFKSTARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTrlfSVCDERWADDLYPKIYHSCFFI 221
Cdd:cd15056   97 DRYYAICcQPLVYKMTPLRVAVMLGGCWVIPTFI-----------SFLPIMQGWN---HIGIEDLIAFNCASGSTSCVFM 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 V-----------TYLAPLGLMAMAYFQIFR--KLWGRQIpgttSALVRNWKRPSdqlgdleqglsgEPQPRARAflaevk 288
Cdd:cd15056  163 VnkpfaiicstvAFYIPALLMVLAYYRIYVaaREQAHQI----RSLQRAGSSNH------------EADQHRNS------ 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 QMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqasdrEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15056  221 RMRTETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGY-------RVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRA 293

                 .
gi 205804177 369 F 369
Cdd:cd15056  294 F 294
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
63-369 2.53e-27

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 110.62  E-value: 2.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15058   17 GNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPqaAVMECSSVLPELANRTRLFSVCDERWADDLYpKIYHSCf 219
Cdd:cd15058   97 DRYIAITRPLRYQVllTKRRARVIVCVVWIVSALVsFVP--IMNQWWRANDPEANDCYQDPTCCDFRTNMAY-AIASSV- 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 fiVTYLAPLGLMAMAYFQIFrKLWGRQIPGTTSALVRnwkRPSDQLGDLEQGLSGEPQ-PRARAFLAEVKQMRArrktAK 298
Cdd:cd15058  173 --VSFYIPLLIMIFVYARVF-LIATRQLQLIDKRRLR---FQSECPAPQTTSPEGKRSsGRRPSRLTVVKEHKA----LK 242
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLkRVFGmfRQASDREAvyacFTFSHWLVYANSAANPIIYnFLSGKFREQF 369
Cdd:cd15058  243 TLGIIMGTFTLCWLPFFIANII-NVFN--RNLPPGEV----FLLLNWLGYINSGLNPIIY-CRSPEFRTAF 305
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
63-373 1.11e-26

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 108.03  E-value: 1.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15092   17 GNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPqAAVM----------ECSSVLPElanrtrlfsvcderwADDL 210
Cdd:cd15092   96 DRYVAICHPIkaLDVRTPHKAKVVNVCIWALASVVGVP-VMVMgsaqvedeeiECLVEIPT---------------PQDY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 211 YPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsalvrnwkrpsdqlgdleqgLSGEPQpraraflaevkQM 290
Cdd:cd15092  160 WDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRL------------------------LSGSKE-----------KD 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 291 RARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGmFRQASDREAVYACFTFShwLVYANSAANPIIYNFLSgkfrEQFK 370
Cdd:cd15092  205 RNLRRITRLVLVVVAVFVGCWTPIQIF-VLAQGLG-VQPSSETAVAILRFCTA--LGYVNSSLNPVLYAFLD----ENFK 276

                 ...
gi 205804177 371 AAF 373
Cdd:cd15092  277 ACF 279
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
63-369 2.22e-26

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 106.68  E-value: 2.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15061   16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAavmecssVLPELANRTRLFSVCderWADDLYPKIYHScff 220
Cdd:cd15061   96 DRYFAITYPLKYrtKRSRRLAITMILAVWVISLLITSPPL-------VGPSWHGRRGLGSCY---YTYDKGYRIYSS--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKML 300
Cdd:cd15061  163 MGSFFLPLLLMLFVYLRIFRVI------------------------------------------------AKERKTAKTL 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15061  195 AIVVGCFIVCWLPFFIMYLIE----PFCDCQFSEALSTAFT---WLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
63-369 2.71e-26

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 107.44  E-value: 2.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15065   16 GNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASILNLCAISL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPQAavMECSSVLPELANRTRLFSVCDERWADDLYP--KIYHS 217
Cdd:cd15065   96 DRYIHIKKPLKYERwmTTRRALVVIASVWILSALIsFLPIH--LGWHRLSQDEIKGLNHASNPKPSCALDLNPtyAVVSS 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CF-FIVtylaPLGLMAMAYFQIFR--KLWGRQIpgttsalvRNWKRPSdqlgdlEQGLSGEPQPRARaflAEVKQMRARR 294
Cdd:cd15065  174 LIsFYI----PCLVMLLIYSRLYLyaRKHVVNI--------KSQKLPS------ESGSKFQVPSLSS---KHNNQGVSDH 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLkrvfgmfrQASDREAV-YACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15065  233 KAAVTLGIIMGVFLICWLPFFIINII--------AAFCKTCIpPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
63-373 3.26e-26

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 106.26  E-value: 3.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15064   17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaavmecssvlPELANRTRLFSVCDE-RWADDLYPKIYHSC- 218
Cdd:cd15064   97 DRYWAITDAVEYahKRTPKRAAVMIALVWTLSICISLP-----------PLFGWRTPDSEDPSEcLISQDIGYTIFSTFg 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 -FFIvtylaPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflAEVKQmrarRKTA 297
Cdd:cd15064  166 aFYI-----PLLLMLILYWKIYR--------------------------------------------AAARE----RKAA 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVlkrVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFlsgkFREQFKAAF 373
Cdd:cd15064  193 KTLGIILGAFIVCWLPFFLVAL---IVPLCSHCWIPLALKSFFL---WLGYFNSLINPLIYTF----FNKDFRKAF 258
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
63-367 7.79e-26

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 105.52  E-value: 7.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15213   17 GNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPlLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANrtrlfsvCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15213   97 DRYLIIVQR-QDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPQ-------CVLGYTESPADRIYVVLLLVA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKrpsdqlgdleqglsgepqprARAFlaevkqmrarrktaKMLMV 302
Cdd:cd15213  169 VFFIPFLIMLYSYFCILNT-------------VRSFK--------------------TRAF--------------TTILI 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 303 VLLVFALCYLPISVLNVLkrvfGMFRQASDreAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15213  202 LFIGFSVCWLPYTVYSLL----SVFSRYSS--SFYVISTCLLWLSYLKSAFNPVIYCWRIKKFRE 260
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
63-369 8.72e-26

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 106.26  E-value: 8.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15134   17 GNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQyPWVFGEVFCKLRAFLSEMSSYASVLTITAFS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVMECSSV-LPELANRTRLFS-VCDERWADDLYPKIYHS 217
Cdd:cd15134   97 VERYLAICHPLRSHtmSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLeYPPTSGEALEESaFCAMLNEIPPITPVFQL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVtYLAPLGLMAMAYFQIfrklwGRQIPGTTSALvRNWKRPSDqlgdleqglsgepqpraraflaEVKQMRARRKTA 297
Cdd:cd15134  177 STFLF-FIIPMIAIIVLYVLI-----GLQLRRSTLLR-RGQRSVSG----------------------GRRSSQSRRTVL 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15134  228 RMLVAVVVAFFICWAPFHAQRLLT-VYAKNMTPPYLFINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
63-369 1.20e-25

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 106.24  E-value: 1.20e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRT-VTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGhALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15320   18 GNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASILNLCVIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLF--KSTARRARGSILGIWAVSLAI-MVP-QAAVMECSSVLPELANRTRLFSVCDErwADDLYPKIYHS 217
Cdd:cd15320   97 VDRYWAISSPFRYerKMTPKVAFIMISVAWTLSVLIsFIPvQLNWHKAKPTSFLDLNASLRDLTMDN--CDSSLNRTYAI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRkLWGRQIPgTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQmraRRKTA 297
Cdd:cd15320  175 SSSLISFYIPVAIMIVTYTRIYR-IAQKQIR-RISALERAAVHAKNCQNSTGNRGSGDCQQPESSFKMSFKR---ETKVL 249
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAV---YACFTFSHWLVYANSAANPIIYNFlSGKFREQF 369
Cdd:cd15320  250 KTLSVIMGVFVCCWLPFFILNCMVP----FCKPTSTEPFcisSTTFDVFVWFGWANSSLNPIIYAF-NADFRKAF 319
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
63-369 2.06e-25

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 104.35  E-value: 2.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15059   17 GNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQaavmecssvlpelanrtrLFSVCDERWADDLYPK------- 213
Cdd:cd15059   97 DRYWSVTQAVEYnlKRTPRRAKAMIAAVWIISAVISLPP------------------LFGWKDEQPWHGAEPQcelsddp 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 --IYHSCffIVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaeVKQMR 291
Cdd:cd15059  159 gyVLFSS--IGSFYIPLLIMIIVYARIYR----------------------------------------------AAKRK 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 292 ARRKTAkMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15059  191 ERRFTL-VLGVVMGAFVLCWLPFFFTYPLV-VVCKTCGVPE-----LLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
63-369 2.46e-25

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 104.98  E-value: 2.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15958   17 GNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTRLFSVCDERWADD------LYPKI 214
Cdd:cd15958   97 DRYLAITSPFRYQSllTRARAKGIVCTVWAISALV-----------SFLPIMMHWWRDEDDQALKCYEDpgccdfVTNRA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARR 294
Cdd:cd15958  166 YAIASSIISFYIPLLIMIFVYLRVYREA----------------KKQIKKIDKCEGRFHNTLTGLGRKCKRRPSRILALR 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 295 --KTAKMLMVVLLVFALCYLPISVLNVLkRVFgmFRQASDREAvyacFTFSHWLVYANSAANPIIYnFLSGKFREQF 369
Cdd:cd15958  230 eqKALKTLGIIMGVFTLCWLPFFLVNVV-NVF--NRELVPDWL----FVFFNWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
63-366 3.75e-25

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 103.47  E-value: 3.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15196   17 GNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMYASSYVLVATAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLL-FKSTARRARGSILGIWAVSLAIMVPQAAVMEcssvLPELANRTRLfsvCDERWADDLYPKIYHSCFFI 221
Cdd:cd15196   97 DRYIAICHPLSsHRWTSRRVHLMVAIAWVLSLLLSIPQLFIFS----YQEVGSGVYD---CWATFEPPWGLRAYITWFTV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKMLM 301
Cdd:cd15196  170 AVFVVPLIILAFCYGRICYVVW-----------------------------------------------RAKIKTVKLTL 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 302 VVLLVFALCYLPISVLNVLkrvfgmfrQASDREAVY--ACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15196  203 VVVACYIVCWTPFFVVQMW--------AAWDPTAPIegPAFVIIMLLASLNSCTNPWIYLAFSGNLR 261
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
63-369 4.24e-25

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 103.16  E-value: 4.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15052   17 GNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTASIMHLCTIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQA--AVMECSSVlpeLANRTRLFSvcderwadDLYPKIYHS 217
Cdd:cd15052   97 LDRYMAIRYPLRTRRnkSRTTVFLKIAIVWLISIGISSPIPvlGIIDTTNV---LNNGTCVLF--------NPNFVIYGS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 --CFFIvtylaPLGLMAMAYFQifrklwgrqipgTTSALvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRK 295
Cdd:cd15052  166 ivAFFI-----PLLIMVVTYAL------------TIRLL------------------------------------SNEQK 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDrEAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15052  193 ASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRIS-PWLLSVFV---WLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
63-369 5.52e-25

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 103.32  E-value: 5.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15094   17 GNGLVIYVVLRYAKMKTVTNLYILNLAVADECFL-IGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPqaaVMECSSVLPELANRTrlfsvCDERWADDlYPKIYHSCF- 219
Cdd:cd15094   96 DRYLAVCHPIRSMRyrTPFIAKVVCATTWSISFLVMLP---IILYASTVPDSGRYS-----CTIVWPDS-SAVNGQKAFt 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 ---FIVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKT 296
Cdd:cd15094  167 lytFLLGFAIPLLLISVFYTLVILRL-RTVGPKNKSKEKR----------------------------------RSHRKV 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAvyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15094  212 TRLVLTVISVYIICWLPYWAFQVHLIFLPPGTDMPKWEI--LMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
63-369 2.49e-24

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 101.72  E-value: 2.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHH--MRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15002   16 GNLMVIGILLNNARkgKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPllfkstARRARGSILGIWAVSLAIMVPQaavmeCSSVLPELANRT------RLFSVCDERWADDLYPKI 214
Cdd:cd15002   96 AKACYMYVVNP------TKQVTIKQRRITAVVASIWVPA-----CLLPLPQWLFRTvkqsegVYLCILCIPPLAHEFMSA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRqipGTTSALVRNWKRpsdqlgdleqglsgepqpraraflaevkqmraRR 294
Cdd:cd15002  165 FVKLYPLFVFCLPLTFALFYFWRAYGQCQRR---GTKTQNLRNQIR--------------------------------SR 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLnvlkrVFGMFRQASDREAVYACFT-FSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15002  210 KLTHMLLSVVLAFTILWLPEWVA-----WLWLIHIKSSGSSPPQLFNvLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
63-369 2.65e-24

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 101.42  E-value: 2.65e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15974   17 GNTLVIYVVLRYAKMKTVTNIYILNLAVADELFM-LGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfKSTA-RRARGSIL---GIWAVSLAIMVPqaaVMECSSVLPElanrtrlFSVCDERWADDLypKIYHSC 218
Cdd:cd15974   96 DRYLAVVHPI--KSTKwRRPRVAKLinaTVWTLSFLVVLP---VIIFSDVQPD-------LNTCNISWPEPV--SVWSTA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVT----YLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqPRARAFLAEVKQMRARR 294
Cdd:cd15974  162 FIIYTavlgFFGPLLVICLCYLLIVIKV-----------------------------------KSSGLRVGSTKRRKSER 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15974  207 KVTRMVVIIVVVFVFCWLPFYMLNIVNLIVIL----PEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
63-369 3.14e-24

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 101.57  E-value: 3.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15089   17 GNVLVMYGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPqAAVMECSSVlPELANRTRLFSVCDERWADDLYPKIyhsCFF 220
Cdd:cd15089   96 DRYIAVCHPVkaLDFRTPAKAKLINICIWVLSSGVGVP-IMVMAVTKT-PRDGAVVCMLQFPSPSWYWDTVTKI---CVF 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGrqipgttsalVRNwkrpsdqlgdleqgLSGEPQpraraflaevkQMRARRKTAKML 300
Cdd:cd15089  171 IFAFVVPILVITVCYGLMILRLRS----------VRL--------------LSGSKE-----------KDRNLRRITRMV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQasdREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15089  216 LVVVAAFIICWTPIHIFVIVWTLVDIDRR---NPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
63-369 4.50e-24

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 100.76  E-value: 4.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15970   17 GNSMVIYVILRYAKMKTATNIYILNLAIADELLM-LSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfkSTARRARGSI-----LGIWAVSLAIMVP----------QAAVMECSSVLPELANRtrlfsvcderwa 207
Cdd:cd15970   96 DRYIAVVHPI---KAARYRRPTVakmvnLGVWVFSILVILPiiifsntapnSDGSVACNMQMPEPSQR------------ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 208 ddlYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgTTSALVRNWKrpsdqlgdleqglsgepqpraraflaev 287
Cdd:cd15970  161 ---WLAVFVVYTFLMGFLLPVIAICLCYILIIVKM-------RVVALKAGWQ---------------------------- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 288 KQMRARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfGMFRQASDREAVyacfTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15970  203 QRKRSERKITLMVMMVVTVFVICWMPFYVVQLV----SVFVGQHDATVS----QLSVILGYANSCANPILYGFLSDNFKR 274

                 ..
gi 205804177 368 QF 369
Cdd:cd15970  275 SF 276
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
63-369 5.29e-24

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 100.69  E-value: 5.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15971   17 GNTLVIYVILRYAKMKTVTNIYILNLAIADELFM-LGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfKSTA----RRARGSILGIWAVSLAIMVPqaaVMECSSVLPELANrtrlfSVCDERWADDlyPKIYHSC 218
Cdd:cd15971   96 DRYLAVVHPI--KSAKwrkpRTAKMINMAVWGVSLLVILP---IMIYAGVQTKHGR-----SSCTIIWPGE--SSAWYTG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 F----FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRARR 294
Cdd:cd15971  164 FiiytFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSS-----------------------------------KRKKSEK 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15971  209 KVTRMVSIVVAVFVFCWLPFYIFNVSS----VSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
63-369 6.20e-24

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 100.41  E-value: 6.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15091   17 GNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTT-MPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVP-----------QAAVMECSSVLPElanrtrlfsvcDERWADD 209
Cdd:cd15091   96 DRYIAVCHPVkaLDFRTPLKAKIINICIWLLSSSVGISaivlggtkvreDVDSTECSLQFPD-----------DDYSWWD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 210 LYPKIyhsCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqPRARAFLAEVKQ 289
Cdd:cd15091  165 TFMKI---CVFIFAFVIPVLIIIVCYTLMILRL-----------------------------------KSVRLLSGSREK 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 290 MRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGmfrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15091  207 DRNLRRITRLVLVVVAVFVVCWTPIHIF-ILVEALG---SVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
63-369 7.56e-24

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 100.19  E-value: 7.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15000   16 GNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMEcssvlpelaNRTRLFSVCDERW-ADD--LYPKIYHSCF 219
Cdd:cd15000   96 DRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRS---------YRERQWKNFLETYcAENtqVLPIYWHVII 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLaPLGLMAMAYFQIFRKLwgrqipgttsalvrNWkrpsdqlgdLEQGLSGEPQPRaraflaevkQMRARRKTAKM 299
Cdd:cd15000  167 TVLVWL-PLGIMLICYSAIFWKL--------------DK---------YERRVLRREHPS---------VVRYKKKAAKT 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 300 LMVVLLVFALCYLPISVLNVL--KRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15000  214 LFIVLITFVVCRIPFTALIFYryKLVPNDNTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
63-367 7.92e-24

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 99.65  E-value: 7.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15210   17 GNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGS--ILGIWAVSLAIMVPqaavmecssVLPELANRTRLF-SVCDERWADDLYPKIYHSCF 219
Cdd:cd15210   97 NRYILIAHPSLYPRIYTRRGLAlmIAGTWIFSFGSFLP---------LWLGIWGRFGLDpKVCSCSILRDKKGRSPKTFL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQifrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKM 299
Cdd:cd15210  168 FVFGFVLPCLVIIICYAR-----------------------------------------------------REDRRLTRM 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 300 LMVVLLVFALCYLPISVLNVlkrvfgmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15210  195 MLVIFLCFLVCYLPITLVNV----------FDDEVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
63-369 9.22e-24

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 100.40  E-value: 9.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFgHAlCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15068   17 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAAC-HG-CLFIACFVLVLTQSSIFSLLAIAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCF 219
Cdd:cd15068   95 DRYIAIRIPLRYNGlvTGTRAKGIIAICWVLSFAIgLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 -FIVTYLAPLGLMAMAYFQIFrkLWGRQipgttsalvrnwkrpsdQLGDLE-QGLSGEpqpRARAFLAevKQMRArrktA 297
Cdd:cd15068  175 nFFACVLVPLLLMLGVYLRIF--LAARR-----------------QLKQMEsQPLPGE---RARSTLQ--KEVHA----A 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 298 KMLMVVLLVFALCYLPISVLNvlkrVFGMFRQASDREA---VYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 369
Cdd:cd15068  227 KSLAIIVGLFALCWLPLHIIN----CFTFFCPDCSHAPlwlMYLAIVLSH----TNSVVNPFIYAYRIREFRQTF 293
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
63-369 1.11e-23

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 99.27  E-value: 1.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15329   17 GNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMecssvlPELANRTRLFSVCDERWaddlYpKIYHScff 220
Cdd:cd15329   97 DRYLVITRPLTYavKRTPKRMALMIAIVWLLSALISIPPLFGW------KNKVNDPGVCQVSQDFG----Y-QIYAT--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsALVRNwkrpsdqlgdleqglsgepqpraraflaevkqmrarRKTAKML 300
Cdd:cd15329  163 FGAFYIPLIVMLVLYYKIYR------------AAKSE------------------------------------RKAIKTL 194
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15329  195 GIIMGAFTLCWLPFFILALLRPFLKPIKCSCIPLWLSRLFL---WLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
63-369 1.61e-23

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 98.86  E-value: 1.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15323   17 GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVlpelANRTRLFSVCDERWAddlypkIYHSCff 220
Cdd:cd15323   97 DRYWSVTQAVEYnlKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPE----GDVYPQCKLNDETWY------ILSSC-- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaeVKQMRARRKTAkML 300
Cdd:cd15323  165 IGSFFAPCLIMILVYIRIYR----------------------------------------------VAKAREKRFTF-VL 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLkrvFGMFRQASdrEAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15323  198 AVVMGVFVVCWFPFFFSYSL---YGICREAC--EVPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
63-369 2.68e-23

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 99.24  E-value: 2.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLvCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLV---DITESWLFG--HALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd14978   17 GNIL-NLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPyiaDYSSSFLSYfyAYFLPYIYPLANTFQTASVWLT 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIY 215
Cdd:cd14978   96 VALTVERYIAVCHPLKARtwCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETYLLKYY 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWkrpsdqlgdleqglsgepqpraraflaEVKQMRARRK 295
Cdd:cd14978  176 FWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRL---------------------------LSRSQRRERR 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVLKRVFGmfrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14978  229 TTIMLIAVVIVFLICNLPAGILNILEAIFG---ESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
63-358 4.07e-23

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 98.78  E-value: 4.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15957   17 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTRlfsvCDERWADDLYPKiYHSCFF 220
Cdd:cd15957   97 DRYFAITSPFKYQSllTKNKARVIILMVWIVSGLT-----------SFLPIQMHWYR----ATHQEAINCYAE-ETCCDF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 -----------IVTYLAPLGLMAMAYFQIFRKLwGRQIPGTTSALVRNWKRPSDQLGDleqGLSGEPQPRARAFLAEvkq 289
Cdd:cd15957  161 ftnqayaiassIVSFYVPLVIMVFVYSRVFQEA-KRQLQKIDKSEGRFHNQNIDQNGS---GGGGGNRRRSKFCLKE--- 233
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 290 mrarRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgmfrqaSDREAVYACFTFSHWLVYANSAANPIIY 358
Cdd:cd15957  234 ----HKALKTLGIIMGTFTLCWLPFFIVNIVHVI-------QDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
63-360 6.17e-23

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 97.62  E-value: 6.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15055   17 GNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVP----------QAAVMECSSVLPELANrtRLFSVCDerwaddl 210
Cdd:cd15055   97 DRYVAVCDPLLYptKITIRRVKICICLCWFVSALYSSVllydnlnqpgLIRYNSCYGECVVVVN--FIWGVVD------- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 211 ypkiyhscfFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNWKRpsdQLGDLEQGLSGEPQPRARAflaevkqM 290
Cdd:cd15055  168 ---------LVLTFILPCTVMIVLYMRIFV-------------VARSQAR---AIRSHTAQVSLEGSSKKVS-------K 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 291 RARRKTAKMLMVVLLVFALCYLPISVLNvlkrVFGMFRQASDreAVYACFTfshWLVYANSAANPIIYNF 360
Cdd:cd15055  216 KSERKAAKTLGIVVGVFLLCWLPYYIVS----LVDPYISTPS--SVFDVLI---WLGYFNSCLNPLIYAL 276
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 9.44e-23

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 97.60  E-value: 9.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPasllVDITESW-----LFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15133   17 GNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMP----LELYELWqnypfLLGSGGCYFKTFLFETVCLASILNV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVMECSSvLPELANRTRLFSVCDERWADDLYPKIY 215
Cdd:cd15133   93 TALSVERYIAVVHPLAARtcSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKF-LGSGVPASAQCTVRKPQAIYNMIPQHT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFFivtyLAPLGLMAMAYFQIfrKLWGRQipgttsalvrnwkrpsdQLGDLEQGLSGEPQPRARAFLAevkQMRARRK 295
Cdd:cd15133  172 GHLFF----VLPMAVISVLYLLM--ALRLAR-----------------ERGLDATGAGSKIGTRTGQLLQ---HPRTRAQ 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASD-REAVYACFTFSH----WLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15133  226 VTKMLFILVVVFAICWAPFHIDRL------MWSFISDwTDNLHEVFQYVHiisgVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
63-369 1.04e-22

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 96.73  E-value: 1.04e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15060   17 GNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCAIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQaavmecssvlpelanrtrLFSVCDerWADDLYPK------- 213
Cdd:cd15060   97 DRYWAIHDPINYaqKRTLKRVLLMIVVVWALSALISVPP------------------LIGWND--WPENFTETtpctlte 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 -----IYHS--CFFIvtylaPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflAE 286
Cdd:cd15060  157 ekgyvIYSSsgSFFI-----PLLIMTIVYVKIFI--------------------------------------------AT 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 VKQmrarRKTAKMLMVVLLVFALCYLPISVLNVLkRVFGMFRQASDREAvyacfTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15060  188 SKE----RRAARTLGIIMGVFVVCWLPFFLMYVI-LPFCETCSPSAKVV-----NFITWLGYVNSALNPVIYTIFNLDFR 257

                 ...
gi 205804177 367 EQF 369
Cdd:cd15060  258 RAF 260
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
63-369 1.06e-22

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 96.58  E-value: 1.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15310   17 GNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGvWNFSRICCDVFVTLDVMMCTASILNLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFK-----STARRARGSILGIWAVSLAIMVPqaavmecssvLPELANRTRLFSVCDERWADDLypkIYH 216
Cdd:cd15310   97 IDRYTAVVMPVHYQhgtgqSSCRRVSLMITAVWVLAFAVSCP----------LLFGFNTTGDPTVCSISNPDFV---IYS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 ScffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKT 296
Cdd:cd15310  164 S---VVSFYLPFGVTLLVYVRIYVVL------------------------------------------------LREKKA 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKrvfGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15310  193 TQMLAIVLGAFIVCWLPFFLTHILN---THCQACHVPPELYSATT---WLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
63-366 1.36e-22

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 96.83  E-value: 1.36e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15008   16 GNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSvlpelANRTRLFsvCDERWADDLYPKIYhscfFIV 222
Cdd:cd15008   96 DRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGSNW-----GPHCNFF--LPDSWDGAAYAIIH----LLV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTTsalvrnwkrpsdqlgdLEQGLSGEPqpraraflaevkqmRARRKTAKMLMV 302
Cdd:cd15008  165 GFLVPSILIILFYQKVIKYIWRIGTDGRT----------------VRRTMNIVP--------------RTKVKTIKMFLM 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 303 VLLVFALCYLPISVLNVLKrvfgmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15008  215 LNSMFLLSWLPFYVVQLWH------PRESDYRQSSLVFLAVTWISFSSSASKPTLYSVYNANFR 272
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
63-369 1.48e-22

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 96.85  E-value: 1.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPasllVDITESW-----LFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15357   17 GNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMP----LEVYEMWsnypfLFGPVGCYFKTALFETVCFASILSV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAV-------MECSSVLPELANRTrlfsVCDERWAD 208
Cdd:cd15357   93 TTVSVERYVAILHPFRAKlnSTRERALKIIVVLWVLSVLFSIPNTSIhgiklqyFPNGTLIPDSATCT----VVKPLWIY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 DLYPKIYHSCFfivtYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVrNWKRPSdqlgdleqglsgepqpraraflaevk 288
Cdd:cd15357  169 NLIIQITSLLF----YVLPMGVISVLYYLMGLKLRGDKSLEADEMNV-NIQRPS-------------------------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 qmraRRKTAKMLMVVLLVFALCYLPISVlnvlKRVFGMFRQASDrEAVYACFTFSH----WLVYANSAANPIIYNFLSGK 364
Cdd:cd15357  218 ----RKSVTKMLFVLVLVFAICWAPFHV----DRLFFSFVVEWT-EPLANVFNLIHvvsgVFFYLSSAVNPIIYNLLSRR 288

                 ....*
gi 205804177 365 FREQF 369
Cdd:cd15357  289 FRTAF 293
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
63-369 1.83e-22

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 96.90  E-value: 1.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15959   17 GNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVpqAAVMECSSVLPELANRTRLFSvcDERWADDLYPKIYHSCFF 220
Cdd:cd15959   97 DRYLAITNPLRYEAlvTKRRARTAVCLVWAISAAISF--LPIMNQWWRDGADEEAQRCYD--NPRCCDFVTNMPYAIVSS 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFrKLWGRQIPGTTSALVRNWKRPSDqlgdLEQGLSGEPQPRARafLAEVKQMRArrktAKML 300
Cdd:cd15959  173 TVSFYVPLLVMIFVYVRVF-VVATRQVRLIRKDKVRFPPEESP----PAESRPACGRRPSR--LLAIKEHKA----LKTL 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrVFGmfRQASDREAvyacFTFSHWLVYANSAANPIIYnFLSGKFREQF 369
Cdd:cd15959  242 GIIMGTFTLCWLPFFVANIIK-VFC--RSLVPDPA----FLFLNWLGYANSAFNPIIY-CRSPDFRSAF 302
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
63-369 1.91e-22

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 95.73  E-value: 1.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15325   17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPelanrtrLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15325   97 DRYIGVSYPLRYPSimTERRGLLALLCVWVLSLVI-----------SIGP-------LFGWKEPAPEDETICQITEEPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IV-----TYLAPLGLMAMAYFqifrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraRAFLAEVKQMRaRRK 295
Cdd:cd15325  159 ALfsalgSFYLPLAIILVMYC--------------------------------------------RVYVVALKFSR-EKK 193
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15325  194 AAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSD------TVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
63-367 2.47e-22

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 95.98  E-value: 2.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLP--ASLLVdITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15088   17 GNGIVLYVLVRCSKLRTAPDIFIFNLAVAD-LLFMLGMPflIHQFA-IDGQWYFGEVMCKIITALDANNQFTSTYILTAM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPllFKSTARRARGS----ILGIWAVSLAIMVPqaaVMECSSVLPELANRTrlfsVCDERWADDLYPKIYH 216
Cdd:cd15088   95 SVDRYLAVVHP--IRSTKYRTRFVaklvNVGLWAASFLSILP---VWVYSSLIYFPDGTT----FCYVSLPSPDDLYWFT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpsdqlgdleqglsgepqPRARAflaevkqmrarRKT 296
Cdd:cd15088  166 IYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSH------------------------GSSRT-----------KRV 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKrvFGMFRQASdreAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15088  211 TKMVILIVVVFIVCWLPFHVVQLVN--LAMNRPTL---AFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
63-369 2.94e-22

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 95.34  E-value: 2.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15326   17 GNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELAnrtrlfsvcderWADDLYPKIYHScff 220
Cdd:cd15326   97 DRYIGVRHSLQYPTivTRKRAILALLGVWVLSTVI-----------SIGPLLG------------WKEPAPPDDKVC--- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 ivtylaplGLMAMAYFQIFRKLWGRQIPGTTSALVrnwkrpsdqlgdleqglsgepqpRARAFLAEVKQMRaRRKTAKML 300
Cdd:cd15326  151 --------EITEEPFYALFSSLGSFYIPLIVILVM-----------------------YCRVYIVALKFSR-EKKAAKTL 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15326  199 GIVVGMFILCWLPFFIALPLGSLFSHLKPPE------TLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
63-369 4.66e-22

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 94.87  E-value: 4.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15063   17 GNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVP-------QAAVMECSSVLPELANRTRLfsvcderwADDLYPK 213
Cdd:cd15063   97 DRYLAITRPIRYPSlmSTKRAKCLIAGVWVLSFVICFPplvgwndGKDGIMDYSGSSSLPCTCEL--------TNGRGYV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYH--SCFFIvtylaPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqMR 291
Cdd:cd15063  169 IYSalGSFYI-----PMLVMLFFYFRIYRA------------------------------------------------AR 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfGMFRQASDREAVYACFtfsHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15063  196 METKAAKTVAIIVGCFIFCWLPFFTVYLV----RAFCEDCIPPLLFSVF---FWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
63-360 6.45e-22

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 94.83  E-value: 6.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15212   17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSrPGWLFGDRLCLANGFFNACFGIVSTLTMTLIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPqaavMECSSVLPELANRTRlFSVCDERWADDLYP--KIYHSCF 219
Cdd:cd15212   97 FDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLP----WYLLASAPEYYEKLG-FYHCLYVLHSGPSRlgAAYSSVL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNwkrpsdqlgdleqglsGEPQPRARAFLAEVKQMRARRKTAKM 299
Cdd:cd15212  172 IVLCYLLPFALMCFCHYNICK-------------TVRL----------------SESRVRPVTTYAHLLRFYSEMRTATT 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGM-FRQASDREAVyacftfshWLVYANSAANPIIYNF 360
Cdd:cd15212  223 VLIMIVFIICCWGPYCLLGLVAAAGGYqFPPLMDTVAI--------WMAWANGAINPLIYAI 276
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
63-369 9.65e-22

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 94.09  E-value: 9.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15062   17 GNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTRLFSvcDERWADDLYPKIYHSCFF 220
Cdd:cd15062   97 DRYIGVRYPLNYPTivTARRATVALLIVWVLSLVI-----------SIGPLLGWKEPAPA--DEQACGVNEEPGYVLFSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqprarAFlaevkQMRARRKTAKML 300
Cdd:cd15062  164 LGSFYLPLAIILVMYCRVYVV----------------------------------------AF-----KFSREKKAAKTL 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15062  199 GIVVGAFVLCWFPFFVVLPLGSLFSTLKPPE------PVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
76-369 1.31e-21

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 94.05  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  76 HMRTVTNY--FIVNLSLADVLVtAICLPasLLVDI---TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICH 150
Cdd:cd14991   28 HSRTWKANtvYLFNLVLADFLL-LICLP--FRIDYylrGEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 151 PLLFKSTA--RRARGSILGIWAVSLAIMVPQAAvmecSSVLPELANRTRLFSVcdERWADDLYPKIYHSCFFIVTYLAPL 228
Cdd:cd14991  105 PHHRVNRMsvKAAAGVAGLLWALVLLLTLPLLL----STLLTVNSNKSSCHSF--SSYTKPSLSIRWHNALFLLEFFLPL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 229 GLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpsdqlgdleqglsgePQPRARaflaevkqmRARRktakMLMVVLLVFA 308
Cdd:cd14991  179 GLIVFCSVRIACNLRIRQSLG--------------------------KQARVQ---------RAIR----LVFLVVIVFV 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 309 LCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14991  220 LCFLPSIIAGLLALVFKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-367 1.37e-21

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 94.04  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNtLVCLaVWRNHHMRTVTNY--FIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd14999   16 GN-VYTL-VVMCLSMRPRASMyvYILNLALAD-LLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVM 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLfsvCDERWADDLYpKIYHSCF 219
Cdd:cd14999   93 STERYLAVVKPLdTVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRI---CLPTWSEESY-KVYLTLL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpsdqlgdleqglsgepqpRARaflaevkqmRARRKTAKM 299
Cdd:cd14999  169 FSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSS-------------------------RKR---------LPKQKVLKM 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFtFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd14999  215 IFTIVLVFWACFLPFWIWQLLY-LYSPSLSLSPRTTTYVNY-LLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
63-369 1.56e-21

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 93.26  E-value: 1.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15050   17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPelanRTRLFSVCDERWADDLYPKIYHScff 220
Cdd:cd15050   97 DRYRSVQQPLkyLKYRTKTRASLMISGAWLLSFLWVIPILGWHHFARGGE----RVVLEDKCETDFHDVTWFKVLTA--- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKML 300
Cdd:cd15050  170 ILNFYIPSLLMLWFYAKIF------------------------------------------------KAVNRERKAAKQL 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15050  202 GFIMAAFILCWIPYFILFMVI----AFCKNCCNENLH---MFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
63-369 1.70e-21

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 93.09  E-value: 1.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15322   17 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELAnrtrLFSVCDERWAddlypkIYHSCff 220
Cdd:cd15322   97 DRYWSITQAIEYnlKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGP----ICKINDEKWY------IISSC-- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaEVKQMRARRKTAkML 300
Cdd:cd15322  165 IGSFFAPCLIMVLVYIRIY----------------------------------------------QIAKNREKRFTF-VL 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyaCFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15322  198 AVVIGVFVICWFPFFFTYTLTAVCDCSVPET-------LFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
63-369 2.32e-21

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 93.62  E-value: 2.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15195   17 GNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPE--LANRTRLFSVCDERWADdlypKIYHSCFF 220
Cdd:cd15195   97 DRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEqpGFHQCVDFGSAPTKKQE----RLYYFFTM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGdleqglsgepqpraraflaevkqmRARRKTAKML 300
Cdd:cd15195  173 ILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNRRRSRTNSLE------------------------RARMRTLRMT 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFShwlvYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15195  229 ALIVLTFIVCWGPYYVLGLWYWFDKESIKNLPPALSHIMFLLG----YLNPCLHPIIYGVFMKEIRNWI 293
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
63-369 3.01e-21

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 93.29  E-value: 3.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPasllVDITESW-----LFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15358   17 GNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMP----LELYEMWsnypfLLGAGGCYFKTLLFETVCFASILNV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPQAAV-------MECSSVLPELAnrtrLFSVCDERWAD 208
Cdd:cd15358   93 TALSVERYIAVVHPLKAKYVVTRthAKRVIGAVWVVSILCSIPNTSLhgifqltVPCRGPVPDSA----TCMLVKPRWMY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 DLYPKIYHSCFFIVtylaPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkRPSDQLGDLEQGLSGEPQPRARAFLAEVK 288
Cdd:cd15358  169 NLIIQITTLLFFFL----PMGTISVLYLLIGLQL-----------------KREKMLLVLEAKGSKAGDSYQHRRIQQEK 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 qmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFrqasdREAVYACFTFSHW----LVYANSAANPIIYNFLSGK 364
Cdd:cd15358  228 --RRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSFISQW-----TGELHLAFQYVHIisgvFFYLSSAANPVLYNLMSTR 300

                 ....*
gi 205804177 365 FREQF 369
Cdd:cd15358  301 FREMF 305
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
63-369 3.15e-21

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 93.19  E-value: 3.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15312   17 GNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAI-------------MVPQAAVMECSSVLPELANrtrlfsvcderwa 207
Cdd:cd15312   97 DRYYAVCDPLHYrtKITTPVIKVFLVISWSVPCLFafgvvfsevnlegIEDYVALVSCTGSCVLIFN------------- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 208 ddlypKIYHSCFFIVTYLAPLGLMAMAYFQIF---RKlwgrqipgttSALVRNwKRPSDQLGDLEQGLSGepqprarafl 284
Cdd:cd15312  164 -----KLWGVIASLIAFFIPGTVMIGIYIKIFfvaRK----------HAKVIN-NRPSVTKGDSKNKLSK---------- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 285 aevkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTfshWLVYANSAANPIIYNFLSGK 364
Cdd:cd15312  218 ------KKERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNF----STPVDLFDALV---WLGYFNSTCNPLIYGFFYPW 284

                 ....*
gi 205804177 365 FREQF 369
Cdd:cd15312  285 FQKAF 289
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
63-369 3.31e-21

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 93.48  E-value: 3.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRT-VTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGhALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15319   17 GNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASILNLCVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLF--KSTARRARGSILGIWAVSLAI-MVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSC 218
Cdd:cd15319   96 VDRYWAISSPFRYerKMTQRVALVMISVAWTLSVLIsFIPVQLNWHKDSGDDWVGLHNSSISRQVEENCDSSLNRTYAIS 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRkLWGRQIpgttsalvrnwKRPSDQLGDLEQGLSGEPQPRARAFLAEVK-QMRARRKTA 297
Cdd:cd15319  176 SSLISFYIPVAIMIVTYTRIYR-IAQIQI-----------RRISSLERAAEHAQSCRSNRIDCHHHTSLRtSIKKETKVL 243
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLkrVFGMFRQASDREAVYAC-----FTFSHWLVYANSAANPIIYNFlSGKFREQF 369
Cdd:cd15319  244 KTLSVIMGVFVCCWLPFFILNCM--VPFCDRPPADPDAGLPCvsettFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
63-369 6.14e-21

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 91.61  E-value: 6.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15049   17 GNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanRTRLFSVCDERWADDLYPKIYHScff 220
Cdd:cd15049   97 DRYFSVTRPLTYraKRTPKRAILMIALAWVISFVLWAP--AILGWQYFVGE---RTVPDGQCYIQFLDDPAITFGTA--- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkQMRARRKTAKML 300
Cdd:cd15049  169 IAAFYLPVLVMTILYWRIYR------------------------------------------------ETARERKAARTL 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVfgmfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15049  201 SAILLAFIITWTPYNILVLVSTF-------CAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
63-366 9.59e-21

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 91.99  E-value: 9.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRN-HHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15382   17 GNLTVLLILLRNrRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSvLPELANrtrlFSVC--DERWADDLYPKIYHSCF 219
Cdd:cd15382   97 LDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVES-HPCVTW----FSQCvtFNFFPSHDHELAYNIFN 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGDLEQGLSGEPQPR--ARAFLAevkqmRARRKTA 297
Cdd:cd15382  172 MITMYALPLIIIVFCYSLILCEI----------------SRKSKEKKEDVSEKSSSVRLRrsSVGLLE-----RARSRTL 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKrvfgMFRQAS----DREAVYACFTFShwlvYANSAANPIIYNFLSGKFR 366
Cdd:cd15382  231 KMTIVIVLVFIICWTPYFIMSLWY----WFDRESaskvDPRIQKGLFLFA----VSNSCMNPIVYGYFSIDLR 295
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
63-369 1.20e-20

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 91.21  E-value: 1.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15090   17 GNFLVMYVIVRYTKMKTATNIYIFNLALADALATST-LPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPqAAVMECSSVLPELANRTRLFSVCDERWADDLypKIyhsCFF 220
Cdd:cd15090   96 DRYIAVCHPVkaLDFRTPRNAKIVNVCNWILSSAIGLP-VMFMATTKYRQGSIDCTLTFSHPSWYWENLL--KI---CVF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsALVRNwkrpsdqlgdleqgLSGEPQpraraflaevkQMRARRKTAKML 300
Cdd:cd15090  170 IFAFIMPVLIITVCYGLMILRL----------KSVRM--------------LSGSKE-----------KDRNLRRITRMV 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTfshwLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15090  215 LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA----LGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
63-369 1.40e-20

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 91.15  E-value: 1.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHAL---CKVIPYLQAvsvsvAVLTLSF 139
Cdd:cd15069   17 GNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLflaCFVLVLTQS-----SIFSLLA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVP-------QAAVMECSSVLPELANRTRLFSVCderWADD 209
Cdd:cd15069   92 VAVDRYLAIKVPLRYKSlvTGKRARGVIAVLWVLAFGIgLTPflgwnkaMSATNNSTNPADHGTNHSCCLISC---LFEN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 210 LYPKIYHSCF-FIVTYLAPLGLMAMAYFQIFRkLWGRQIPGTtsalvrnwkrpsdqlgdleqglsgEPQPRARAFLAevK 288
Cdd:cd15069  169 VVPMSYMVYFnFFGCVLPPLLIMLVIYIKIFL-VACRQLQRT------------------------ELMDHSRTTLQ--R 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 QMRArrktAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHwlvyANSAANPIIYNFLSGKFREQ 368
Cdd:cd15069  222 EIHA----AKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAILLSH----ANSVVNPIVYAYRNRDFRYT 293

                 .
gi 205804177 369 F 369
Cdd:cd15069  294 F 294
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
63-369 1.51e-20

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 90.74  E-value: 1.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15327   17 GNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRTRLFSvcDERWADDLYPKIYHSCFF 220
Cdd:cd15327   97 DRYVGVKHSLKYPTimTERKAGVILVLLWVSSMVI-----------SIGPLLGWKEPPPP--DESICSITEEPGYALFSS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFqifrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraRAFLAEVKQMRaRRKTAKML 300
Cdd:cd15327  164 LFSFYLPLMVILVMYF--------------------------------------------RVYVVALKFSR-EKKAAKTL 198
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASdreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15327  199 AIVVGVFILCWFPFFFVLPLGSFFPALKPSE------MVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
63-369 2.39e-20

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 90.30  E-value: 2.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15973   17 GNSMVIFVILRYAKMKTATNIYILNLAIADELFM-LSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFCLTVLSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfkSTARRARGSI-----LGIWAVSLAIMVPQAavmecssVLPELANRTRLFSVCDERWADDLYPKIYHS 217
Cdd:cd15973   96 DRYIAVVHPL---RAARYRRPTVakminICVWILSLLVISPII-------IFADTATRKGQAVACNLIWPHPAWSAAFVI 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFLAEVKQMR-ARRKT 296
Cdd:cd15973  166 YTFLLGFLLPVLAIGLCYILIIGKM------------------------------------RAVALKAGWQQRRkSEKKI 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFShwlvYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15973  210 TRMVLMVVTVFVICWMPFYVVQLLN----LFLPRLDATVNHASLILS----YANSCANPILYGFLSDNFRRSF 274
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-363 2.84e-20

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 90.65  E-value: 2.84e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15387   17 GNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLLLMSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfKSTARRA-RGSILGIWAVSLAIMVPQAAVMECSSVLPELANrtrlfsvCderWADDLYP---KIYHSC 218
Cdd:cd15387   97 DRCLAICQPL--RSLHRRSdRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYD-------C---WADFIQPwgpKAYITW 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvRNWKRPSDQlgdlEQGLSGEPQPRARAFLAEVKQMR----ARR 294
Cdd:cd15387  165 ITLSVYIIPVLILSVCYGLISFKIW------------QNVKLKTRR----ETKTPLSSAASGGAALARVSSVKliskAKI 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDREAvyACFTFSHWLVYANSAANPIIYNFLSG 363
Cdd:cd15387  229 RTVKMTFVIVLAYIVCWTPFFFV----QMWSVWDPNAPKEA--SPFIIAMLLASLNSCCNPWIYMFFTG 291
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
63-242 2.88e-20

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 89.83  E-value: 2.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15398   17 GNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMSIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVP-----QAAVMECSSVLPELANRtrlfSVCDERWADDLYPKIYHS 217
Cdd:cd15398   97 VRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPlpvfhKIVDLSETFNLESLKNK----YLCIESWPSDSYRIAFTI 172
                        170       180
                 ....*....|....*....|....*
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKL 242
Cdd:cd15398  173 SLLFVQYILPLVCLTVSHTSVCRSV 197
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
63-369 3.27e-20

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 89.74  E-value: 3.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15066   16 GNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASILHLCCISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAImvpqaavmecsSVLPEL-----ANRTRLFSVCDERWADDLYPKIY 215
Cdd:cd15066   96 DRYYAIVQPLEYpsKMTKRRVAIMLANVWISPALI-----------SFLPIFlgwytTEEHLQYRKTHPDQCEFVVNKIY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkQMRARRK 295
Cdd:cd15066  165 ALISSSVSFWIPCIVMIFTYYRIYL------------------------------------------------EAKREHK 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDReAVYACFtfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15066  197 AAKTLGIIMGAFILCWLPFFLWYVTTTLCGDACPYPPI-LVSILF----WIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
63-366 5.00e-20

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 89.56  E-value: 5.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15131   17 GNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIF-LCMPLDLYrLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVM--------------ECSSVlpELANRTRLFSVCdeR 205
Cdd:cd15131   96 VERYFAICFPLRAKVvvTKRRVKLVILVLWAVSFLSAGPIFVLVgvehengtnpidtnECKAT--EYAVRSGLLTIM--V 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 206 WADDLYpkiyhscFFIvtylaPLGLMAMAYFQIFRKLWGRQipgttsalvRNWKRPSDQLGDleqglsgepqprarafla 285
Cdd:cd15131  172 WVSSVF-------FFL-----PVFCLTVLYSLIGRKLWRRR---------RENIGPNASHRD------------------ 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 286 evkqmRARRKTAKMLMVVLLVFALCYLPISVLNVLkrVFGMFRQASDREAVYA--CFTFSHWLVYANSAANPIIYNFLSG 363
Cdd:cd15131  213 -----KNNRQTVKMLAVVVFAFVLCWLPFHVGRYL--FSKSFEAGSLEIALISqyCNLVSFVLFYLSAAINPILYNIMSK 285

                 ...
gi 205804177 364 KFR 366
Cdd:cd15131  286 KYR 288
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
63-369 5.31e-20

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 89.48  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15972   17 GNTLVIYVVLRYSASESVTNIYILNLALADELFM-LGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFCLTVMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAvmecssvlpeLANRTRLFSVCDERWADDlyPKIYHSCFF 220
Cdd:cd15972   96 DRYLAVVHPIRSSKwrKPPVAKTVNATVWALSFLVVLPVVI----------FSGVPGGMGTCHIAWPEP--AQVWRAGFI 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVT----YLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRpsdqlgdleqglsgepqpRARAflAEVKQMRARRKT 296
Cdd:cd15972  164 IYTatlgFFCPLLVICLCYLLIVVK-------------VRSSGR------------------RVRA--TSTKRRGSERKV 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKRVFGMfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15972  211 TRMVVIVVAAFVLCWLPFYALNIVNLVCPL----PEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
63-367 5.54e-20

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 89.70  E-value: 5.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15083   17 GNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQAavMECSSVLPElanrTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15083   97 DRYLVITRPMkaSVRISHRRALIVIAVVWLYSLLWVLPPL--FGWSRYVLE----GLLTSCSFDYLSRDDANRSYVICLL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKlwgrqIPGTTSALVRNWKRPSDQlgdleqgLSGEPQPRARaflAEVkqmrarrKTAKML 300
Cdd:cd15083  171 IFGFVLPLLIIIYCYSFIFRA-----VRRHEKAMKEMAKRFSKS-------ELSSPKARRQ---AEV-------KTAKIA 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 301 MVVLLVFALCYLPISVLNVLkrvfgmfrqasdreavyACFTFSHWL---------VYANSAA--NPIIYNFLSGKFRE 367
Cdd:cd15083  229 LLLVLLFCLAWTPYAVVALI-----------------GQFGYLEVLtplataipaAFAKTSAiyNPVIYAFSHPKFRR 289
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
63-369 5.58e-20

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 88.94  E-value: 5.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15309   17 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK---STARRARGSILGIWAVSLAIMVPqaavmecssVLPELANRTRlfSVCderWADDLYPKIYHScf 219
Cdd:cd15309   97 DRYTAVAMPMLYNtrySSKRRVTVMISVVWVLSFAISCP---------LLFGLNNTDQ--NEC---IIANPAFVVYSS-- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 fIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKM 299
Cdd:cd15309  161 -IVSFYVPFIVTLLVYVQIYIVL------------------------------------------------QKEKKATQM 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15309  192 LAIVLGVFIICWLPFFITHILN----MHCDCNIPPALYSAFT---WLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
63-367 6.90e-20

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 89.39  E-value: 6.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15336   17 GNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanrtRLFSVCDerWaDDLYP----KIYH 216
Cdd:cd15336   97 DRYLVITKPLASirWVSKKRAMIIILLVWLYSLAWSLP--PLFGWSAYVPE-----GLLTSCT--W-DYMTFtpsvRAYT 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRPSDQLGDLEQGLSGEPQpraraflaevKQMRARRKT 296
Cdd:cd15336  167 MLLFCFVFFIPLGIIIYCYLFIFLA-------------IRSTGREVQKLGSQDRKEKAKQY----------QRMKNEWKM 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVL-------------KRVFGMFRQASdreAVYacftfshwlvyansaaNPIIYNFLSG 363
Cdd:cd15336  224 AKIAFVVILLFVLSWSPYACVALIawagyahlltpymKSVPAVIAKAS---AIY----------------NPIIYAITHP 284

                 ....
gi 205804177 364 KFRE 367
Cdd:cd15336  285 KYRE 288
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
63-375 7.12e-20

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 88.86  E-value: 7.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15307   17 GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqAAVMECSSVLPELANrtrlfSVCdeRWADDLYpKIYHS--C 218
Cdd:cd15307   97 DRYLSLRYPMRFgrNKTRRRVTLKIVFVWLLSIAMSLP-LSLMYSKDHASVLVN-----GTC--QIPDPVY-KLVGSivC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIvtylaPLGLMAMAYFQifrklwgrqipgTTSALVRNWKRPSdqlgdleqglsgepqpraraflaevKQMRARRKTAK 298
Cdd:cd15307  168 FYI-----PLGVMLLTYCL------------TVRLLARQRSRHG-------------------------RIIRLEQKATK 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAvyacFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSC 375
Cdd:cd15307  206 VLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWV----FDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
63-369 8.18e-20

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 88.97  E-value: 8.18e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPasLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSF 139
Cdd:cd14985   17 GNLFVVWVFLFPRGPKRVADIFIANLAAAD-LVFVLTLP--LWATYTANqydWPFGAFLCKVSSYVISVNMFASIFLLTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFK--STARRARGSILGIWAVSlaimvpqaavmeCSSVLPELANRTRLF------SVCDERWADDLY 211
Cdd:cd14985   94 MSVDRYLAIVHPVASRrlRRRRQARVTCALIWVVA------------CLLSLPTFLLRSLQAienlnkTACIMLYPHEAW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 212 PKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGdleqglsgepqpraraflaevKQMR 291
Cdd:cd14985  162 HFGLSLELNILGFVLPLLIILTCYFHIARSL----------------RKRYERTG---------------------KNGR 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGM--FRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14985  205 KRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLgaIRPCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
63-363 8.28e-20

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 89.06  E-value: 8.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15388   17 SNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASSYMIVAMTF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLL-FKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANrtrlfsvCDERWADDLYPKIYHSCFFI 221
Cdd:cd15388   97 DRHQAICRPMVtFQKGRARWNGPVCVAWAISLILSLPQVFIFSKVEVAPGVYE-------CWACFIEPWGLKAYVTWITL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLW------GRQIPGTTSALVRNWKRPSDqlgdleqglsgepqprarafLAEVKqmRARRK 295
Cdd:cd15388  170 VVFVLPTLIITVCQVLIFKEIHiniylkSQIIVAVVKKKQLLSSRASS--------------------VAEVS--KAMIK 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 296 TAKMLMVVLLVFALCYLPIsvlnVLKRVFGMFRQASDREAvyACFTFSHWLVYANSAANPIIYNFLSG 363
Cdd:cd15388  228 TVKMTLVIVLVYVLCWAPF----FLVQLWSVWDPKAPTEG--ATFTILMLLASLNSCTNPWIYMAFSS 289
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
63-369 1.38e-19

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 88.72  E-value: 1.38e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15385   17 GNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTYMLVMMTA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQAAVMEcssvLPELANRTRLFSVcderWADDLYP---KIYHSC 218
Cdd:cd15385   97 DRYIAICHPLkTLQQPTKRSYLMIGSAWALSFILSTPQYFIFS----LSEIENGSGVYDC----WANFIVPwgiKAYITW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWgRQIPGTTSALVRNWKRPSDQLGdleqglsgepqprarAFLAEVKQM-RARRKTA 297
Cdd:cd15385  169 ITISIFVVPVIILLTCYGFICYNIW-RNIKCKTRRGLSDNALKNILLA---------------VCVSSVKTIsRAKIRTV 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15385  233 KMTFVIVLAYIVCWAPFFTIQMWSVWDQNF---PWDESENTAVTITALLASLNSCCNPWIYMFFSGHLLQDF 301
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
63-369 1.96e-19

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 87.68  E-value: 1.96e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15314   17 GNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSlaimvpqaAVMECSSVLPELANRTRLFS--VCDERWADDLYPKIYHSC 218
Cdd:cd15314   97 DRYYAVCQPLLYRSkiTVRVVLVMILISWSVS--------ALVGFGIIFLELNIKGIYYNhvACEGGCLVFFSKVSSVVG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLaPLGLMAMAYFQIFrklwgrqipgttsaLVRnwKRPSDQLgdleQGLSGEPQPRARaflaevkqmRARRKTAK 298
Cdd:cd15314  169 SVFSFYI-PAVIMLCIYLKIF--------------LVA--QRQARSI----QSARTKSGASSS---------KMERKATK 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISVLNvlkrVFGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15314  219 TLAIVMGVFLLCWTPFFLCN----IIDPFINYSIPPVLIEVLN---WLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 4.00e-19

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 87.22  E-value: 4.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15976   17 GNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTA--RRARGSILGIWAVSLAIMVPQAAVMEcssvLPELANRTRLFSVC----DERWADDLYPKIYH 216
Cdd:cd15976   97 DRYRAVASWSRIKGIGvpKWTAVEIVLIWVVSIILAVPEAIGFD----MITMDYKGELLRICllhpIQKTAFMQFYKTAK 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVTYLA-PLGLMAMAY----FQIFRKLWGRQIpgttsalvrnwkrpsdqlgdleqglsgepqpraraflAEVKQMR 291
Cdd:cd15976  173 DWWLFSFYFClPLACTAVFYtlmtCEMLRKKNGMQI-------------------------------------ALNDHLK 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrqaSDREAVYACFTFSHWLVY---------ANSAANPIIYNFLS 362
Cdd:cd15976  216 QRREVAKTVFCLVLVFALCWLPLHLSRILKLTI------YDEKDPNRCELLSFFLVLdyiginmasLNSCINPIALYLVS 289

                 ....*..
gi 205804177 363 GKFREQF 369
Cdd:cd15976  290 KRFKNCF 296
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
78-369 5.70e-19

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 86.20  E-value: 5.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADVLVTAiCLP---ASLLVDitESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF 154
Cdd:cd14974   31 RTVNTVWFLNLALADFLFCL-FLPfliVYIAMG--HHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPVWA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 155 KS--TARRARGSILGIWAVSLAIMVPQAAVMEcssVLPELANRTRLFSVCDerwADDLYPKIYHSCF---FIVTYLAPLG 229
Cdd:cd14974  108 QNhrTVRLASVVCVGIWILALVLSVPYFVFRD---TVTHHNGRSCNLTCVE---DYDLRRSRHKALTvirFLCGFLLPLL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 230 LMAMAYFQIFRKLwgrqipgttsalvrnwKRpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKMLMVVLLVFAL 309
Cdd:cd14974  182 IIAICYSVIAVKL----------------RR---------------------------KRLAKSSKPLRVLLAVVVAFFL 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 310 CYLPISVLNVLKRVfgmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14974  219 CWLPYHVFALLELV----AAAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
63-369 7.71e-19

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 86.27  E-value: 7.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNH-----HMRTVtnyfIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15383   17 SNLAVLWSATRNRrrklsHVRIL----ILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSAFVT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELAnrtrlFSVC------DERWADdly 211
Cdd:cd15383   93 VVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPVN-----FTQCathgsfPAHWQE--- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 212 pKIYHSCFFIVTYLAPLGLMAMAY----FQIFRKLWGRQIPGTTSALVRnwkRPSDQLgdleqglsgepqPRARAflaev 287
Cdd:cd15383  165 -TLYNMFTFFCLFLLPLLIMIFCYtrilLEISRRMKEKKDSAKNEVALR---SSSDNI------------PKARM----- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 288 kqmrarrKTAKMLMVVLLVFALCYLPISVLNVLKRVF-GMFRQASDREAVYACFTFShwlvYANSAANPIIYNFLSGKFR 366
Cdd:cd15383  224 -------RTLKMTIVIVSSFIVCWTPYYLLGLWYWFSpEMLEQTVPESLSHILFLFG----LLNACLDPLIYGLFTISFR 292

                 ...
gi 205804177 367 EQF 369
Cdd:cd15383  293 RGL 295
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
63-369 1.04e-18

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 85.79  E-value: 1.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtAICLPASlLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15178   17 GNSLVVLVILYNRRSRSSTDVYLLHLAIADLLF-ALTLPFW-AVSVVKGWIFGTFMCKLVSLLQEANFYSGILLLACISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSI-LGIWAVSLAIMVPqaAVMECSSVLPELANRTRLFSVCDERWADDLYpKIYHSCFFI 221
Cdd:cd15178   95 DRYLAIVHATRALTQKRHLVKFVcAGVWLLSLLLSLP--ALLNRDAFKPPNSGRTVCYENLGNESADKWR-VVLRILRHT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAY-FQIFRKLWGRqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqMRARRKTAKML 300
Cdd:cd15178  172 LGFLLPLVVMLFCYgFTIKTLLQTR--------------------------------------------SFQKHRAMRVI 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 301 MVVLLVFALCYLP--ISVL-NVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15178  208 FAVVLAFLLCWLPynVTVLiDTLMRTKLITETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
63-369 1.13e-18

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 84.92  E-value: 1.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15324   17 GNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQaavmecssvLPELANRTRLFSVCDERWAddlypkIYHSCff 220
Cdd:cd15324   97 DRYWSVTKAVSYnlKRTPKRIKRMIAVVWVISAVISFPP---------LLMTKHDEWECLLNDETWY------ILSSC-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaeVKQMRARRKTAkML 300
Cdd:cd15324  160 TVSFFAPGLIMILVYCKIYR----------------------------------------------VAKMREKRFTF-VL 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15324  193 AVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPD-----ALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 1.42e-18

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 85.11  E-value: 1.42e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15182   17 GNGLVLWILVKYEKLKTLTNIFILNLAISD-LLFTFTLPFWASYHSSG-WIFGEILCKAVTSIFYIGFYSSILFLTLMTI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQAavmecssVLPELANRTRLFSVCDErwaDDLYPKIYHSCFF 220
Cdd:cd15182   95 DRYLAVVHPLsaLRSRKLRYASLVSVAVWVISILASLPEL-------ILSTVMKSDEDGSLCEY---SSIKWKLGYYYQQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARaflaevkqMRARRKTAKML 300
Cdd:cd15182  165 NLFFLIPLGIIVYCYVRILQTLM-----------------------------------RTR--------TMRKHRTVKLI 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDRE-----AVYAC--FTFSHWLVyansaaNPIIYNFLSGKFREQF 369
Cdd:cd15182  202 FVIVLVFFLSWAPYNIVIFLRSLKDLTIPICECSkqldyAFYICrnIAFSHCCL------NPVFYVFVGVKFRNHL 271
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
76-369 1.77e-18

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 85.67  E-value: 1.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  76 HMRTVTNYFIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL 153
Cdd:cd15355   33 HLQSTVHYHLASLALSDLLILLLAMPVELynFIWVHHPWAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICHPFK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 154 FKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTrlfsVCdERWADDLYPKIYHSCFFIVTYLAPLGLM 231
Cdd:cd15355  113 AKSlmSRSRTKKFISAIWLASALLAIPMLFTMGEQNRSGTHPGGL----IC-TPIVDTSTLKVVIQVNAFLSFLFPMLVI 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 232 AMAYFQIFRKLwgRQIPGTTSALvrnwkRPSDQLGDLEQGLSGEPQPraraflaevKQMRARRKTAKMLMVVLLVFALCY 311
Cdd:cd15355  188 SVLNTLIANQL--TVMVNQAEQE-----NQVCTIGGQRTVLSVSMEP---------GRVQSLRHGVLVLRAVVIAFVVCW 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 312 LPISVlnvlKRVfgMFRQASDREAVYACFTFSHW-------LVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15355  252 LPYHV----RRL--MFCYVSDEQWTTFLYDFYHYfymltnvLFYVSSAINPILYNLVSANFRQIF 310
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
63-367 1.77e-18

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 84.91  E-value: 1.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15318   17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDErwaddLYPKIYHSCFF 220
Cdd:cd15318   97 DRHCAICDPLLYpsKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELLTSVPCVGSCQL-----LYNKLWGWLNF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVtYLAPLGLMAMAYFQIFrklwgrqipgtTSAlvrnwKRPSDQLGDLEQGLSGEPqpraraflaevkqmRARRKTAKML 300
Cdd:cd15318  172 PV-FFIPCLIMIGLYVKIF-----------IVA-----KRQARAIASLLSDTNGAS--------------KRERKAAKTL 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreavyACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15318  221 GIAVGVYLLCWLPFTIDTMVDSLLNFITPP-------LLFDIIIWFAYFNSACNPLIYVFSYPWFRK 280
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 1.79e-18

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 85.07  E-value: 1.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAI-CLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15337   17 GNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVnGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQ-----AAVME---CSSVLPELANrtrlfsvcderwadDLY 211
Cdd:cd15337   97 IDRYLVIAKPLeaMKKMTFKRAFIMIIIIWLWSLLWSIPPffgwgRYVPEgfqTSCTFDYLSR--------------DLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 212 PKIYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRpsdqlgDLEQGLSGEPQPRARaflAEVKQMR 291
Cdd:cd15337  163 NRLFILGLFIFGFLCPLLIIIFCYVNIIRA-------------VRNHEK------EMTQTAKSGMGKDTE---KNDARKK 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNvlkrVFGMFRQAsdreavyacftfsHWL---------VYANSAA--NPIIYNF 360
Cdd:cd15337  221 AEIRIAKVAIILISLFLLSWTPYAVVA----LLGQFGPA-------------YWItpyvselpvMFAKASAiyNPIIYAL 283

                 ....*....
gi 205804177 361 LSGKFREQF 369
Cdd:cd15337  284 SHPKFRAAL 292
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
76-369 1.91e-18

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 85.06  E-value: 1.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  76 HMR--TVTNYFIVNLSLADVLVtAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL 152
Cdd:cd15168   28 HLKpwNSSAIYMFNLAVSDLLY-LLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 153 --LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSsvlpelanRTRLFSVCDERWADDLYP--KIYHSCFFIVTYLAPL 228
Cdd:cd15168  107 rsLGKLKKRHAVAISVAVWILVLLQLLPILFFATTG--------RKNNRTTCYDTTSPEELNdyVIYSMVLTGLGFLLPL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 229 GLMAMAYFQIFRKLWGRQIPGTTSALvrnwkrpsdqlgdleqglsgepqpraraflaevkqmraRRKTAKMLMVVLLVFA 308
Cdd:cd15168  179 LIILACYGLIVRALIRKLGEGVTSAL--------------------------------------RRKSIRLVIIVLALFA 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 309 LCYLPISV---LNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15168  221 VCFLPFHVtrtINLAARLLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
63-360 3.96e-18

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 84.47  E-value: 3.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAI-CLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15198   17 GNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGtALSQIIWELLGDRWMAGDVACRLLKLLQASARGASANLVVLLA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLlfkSTARRARGSILGIWAVSLAIMVPQAAVMECSSVlPELANRTRLFSVCDERWAD--DLYPKIYHSCF 219
Cdd:cd15198   97 LDRHQAIRAPL---GQPLRAWKLAALGWLLALLLALPQAYVFRVDFP-DDPASAWPGHTLCRGIFAPlpRWHLQVYATYE 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSgepqpraraflaevkqmRARRKTAKM 299
Cdd:cd15198  173 AVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSKSHLRATAPSALP-----------------RAKVKTLKM 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 300 LMVVLLVFALCYLPISVLNvLKRVFGMFRQasDREAVYACFTFshwLVYANSAANPIIYNF 360
Cdd:cd15198  236 TLVIALLFVGCSLPYFIAE-LAAAFGSGDW--EPEKVAAALGV---MAVANSATNPFVFLF 290
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
63-369 4.54e-18

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 83.80  E-value: 4.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLP--AsllVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd14984   17 GNSLVLLVLLYYRKLRSMTDVYLLNLALAD-LLFVLTLPfwA---VYAADGWVFGSFLCKLVSALYTINFYSGILFLACI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICH--PLLFKSTARRARGSILGIWAVSLAIMVPQ---------AAVMECSSVLPELANRT-RLFSVCderwad 208
Cdd:cd14984   93 SIDRYLAIVHavSALRARTLLHGKLTCLGVWALALLLSLPEfifsqvseeNGSSICSYDYPEDTATTwKTLLRL------ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 dlypkIYHSCFFIVtylaPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaEVK 288
Cdd:cd14984  167 -----LQNILGFLL----PLLVMLFCYSRIIRTL-------------------------------------------LRA 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 QMRARRKTAKMLMVVLLVFALCYLPISV---LNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 365
Cdd:cd14984  195 RNHKKHRALRVIFAVVVVFFLCWLPYNIvllLDTLQLLGIISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKF 274

                 ....
gi 205804177 366 REQF 369
Cdd:cd14984  275 RKYL 278
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
63-369 5.32e-18

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 83.67  E-value: 5.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFghALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15070   17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHF--YSCLFMSCLLVVFTHASIMSLLAIAV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK--STARRARGSILGIWAVSLAI-MVPqaavMECSSVLPELANRTRLFSVCDERWADDLYPKIYHScf 219
Cdd:cd15070   95 DRYLRVKLTVRYRivTTQRRIWLALGLCWLVSFLVgLTP----MFGWNRKPSLESVNTTPLQCQFTSVMRMDYMVYFS-- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNwkrpsdqlgDLEQGLSGEPQprARAFlaevkqMRARRKTAKM 299
Cdd:cd15070  169 FFTWILIPLVIMCALYVDIFY-------------IIRN---------KLSQNATGFRE--TGAF------YGREFKTAKS 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHwlvyANSAANPIIYNFLSGKFREQF 369
Cdd:cd15070  219 LALVLFLFAVCWLPLSIINCVV----YFNPKVPKIALYLGILLSH----ANSMMNPIVYACKIKKFKETY 280
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
64-369 6.03e-18

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 83.50  E-value: 6.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITE------SWLFghalckvIPYLQAVSVSVAVLTL 137
Cdd:cd14972   16 NSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSltpspaTWLL-------RKGSLVLSLLASAYSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPqaaVMECSSVLPELANRTRLFSvcderwaddLYPKI 214
Cdd:cd14972   89 LAIAVDRYISIVHGLTYVNnvTNKRVKVLIALVWVWSVLLaLLP---VLGWNCVLCDQESCSPLGP---------GLPKS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVTyLAPLGLMAMAYFQIFRKLWGRqipgtTSALVRNwkrpsdqlgdleqglsgepQPRARAflaevKQMRARR 294
Cdd:cd14972  157 YLVLILVFF-FIALVIIVFLYVRIFWCLWRH-----ANAIAAR-------------------QEAAVP-----AQPSTSR 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLkrVFGMFRQASDREAVYACFTFshwlVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14972  207 KLAKTVVIVLGVFLVCWLPLLILLVL--DVLCPSVCDIQAVFYYFLVL----ALLNSAINPIIYAFRLKEMRRAV 275
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
63-369 6.86e-18

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 83.05  E-value: 6.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15321   23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLfsvCDERWaddlypkiYHSCFF 220
Cdd:cd15321  103 DRYWSVSRAIEYnsKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKL---NEEAW--------YILSSS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaEVKQMRARRKTAkML 300
Cdd:cd15321  172 IGSFFAPCLIMILVYLRIY----------------------------------------------LIAKNREKRFTF-VL 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDreavyACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15321  205 AVVIGVFVLCWFPFFFSYSLGAICPELCKVPH-----SLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
63-369 8.51e-18

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 83.36  E-value: 8.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLqaVSVSVAVLTLSFIAL 142
Cdd:cd15071   17 GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVL--ILTQSSILALLAIAV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPQAAVMECSSVL---PELANRTRLFSVCDERWADDLYPKIYH 216
Cdd:cd15071   95 DRYLRVKIPTRYKSvvTPRRAAVAIAGCWILSFLVgLTPMFGWNNLNAVErawAANSSMGELVIKCQFETVISMEYMVYF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 ScfFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsaLVRNwkrpsdQLGDLEQGLSGEPQpraraflaevKQMRARRKT 296
Cdd:cd15071  175 N--FFVWVLPPLLLMLLIYLEVFY-------------LIRK------QLNKKVSSSSSDPQ----------KYYGKELKI 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVyACFtfshwLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15071  224 AKSLALILFLFALSWLPLHILNCITLFCPSCKKPMILTYI-AIF-----LTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
63-369 9.04e-18

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 82.82  E-value: 9.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVL-VTAICLPAsllVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15180   17 GNGLVLAVLLQKRRNLSVTDTFILHLALADILlLVTLPFWA---VQAVHGWIFGTGLCKLAGAVFKINFYCGIFLLACIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHP--LLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVlpELANRT---RLFSVCDERWADDLypkiyH 216
Cdd:cd15180   94 FDRYLSIVHAvqMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKD--PRQNKTecvHNFPQSDTYWWLAL-----R 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqprarafLAEVKQMRARRKT 296
Cdd:cd15180  167 LLYHIVGFLLPLAVMVYCYTSILLRL-----------------------------------------LRSSQGFQKQRAI 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 297 AKMLMVVlLVFALCYLPISV---LNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15180  206 RVIVAVV-VVFFLCWTPYNIallVDTLIDLSVLDRNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
63-369 1.05e-17

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 82.65  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15401   17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF-KSTARRARGSILGI-WAVSLAIMVPQAAVmecssvlPELANRTRLFSVCDERWADDLYPKIyhscFF 220
Cdd:cd15401   97 NRYCYICHSLRYdKLYNMKKTCCYVCLtWVLTLAAIVPNFFV-------GSLQYDPRIYSCTFAQTVSSSYTIT----VV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFrklwgrqipgttsALVRNWKRPSDQlgDLEQGLSgepQPRARAFLAevkqmrarrktakmL 300
Cdd:cd15401  166 VVHFIVPLSIVTFCYLRIW-------------VLVIQVKHRVRQ--DSKQKLK---ANDIRNFLT--------------M 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVyacFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15401  214 FVVFVLFAVCWGPLNFIGLAVAINPLKVAPKIPEWL---FVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
64-373 1.05e-17

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 82.54  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15333   22 NAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALD 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVP-----QAAVMEcssvlpelanrtrLFSVCDERwADDLYPKIYH 216
Cdd:cd15333  102 RYWAITDAVEYskKRTPKRAAVMIALVWVISISISLPpffwrQAKAEE-------------EVSECVVN-TDHILYTVYS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SC--FFIVTYLaplgLMAMaYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepQPRARaflaevkqmraRR 294
Cdd:cd15333  168 TVgaFYIPTLL----LIAL-YGRIYV------------------------------------EARAR-----------ER 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrqasdREAVY---ACFTFSHWLVYANSAANPIIYNFlsgkFREQFKA 371
Cdd:cd15333  196 KATKTLGIILGAFIVCWLPFFIISLVLPIC--------KDACWfhlAIFDFFTWLGYLNSLINPIIYTM----SNEDFKQ 263

                 ..
gi 205804177 372 AF 373
Cdd:cd15333  264 AF 265
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
63-369 1.18e-17

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 82.29  E-value: 1.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15304   17 GNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTASIMHLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVmecssvlpELANRTRLFSVCDERWADDLYPKIYHscf 219
Cdd:cd15304   97 LDRYIAIRNPIHHSrfNSRTKAFLKIIAVWTISVGISMPIPVF--------GLQDDSKVFKEGSCLLADENFVLIGS--- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 fIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdLEQGLSGEpqpraraflaevkqmrarRKTAKM 299
Cdd:cd15304  166 -FVAFFIPLTIMVITYFLTIKS--------------------------LQQSISNE------------------QKASKV 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15304  201 LGIVFFLFVVMWCPFFITNVMAVI---CKESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
63-367 1.22e-17

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 82.97  E-value: 1.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15403   17 GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPlLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVlPELANRtrlfsvCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15403   97 DRFLIIVQR-QDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEV-PARAPQ------CVLGYTESPADRVYAVLLVVA 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFrklwgrqipgttSALVRNWKRPSDQLGDL------EQGLSGEPQPRARAFlaevkQMRARRKT 296
Cdd:cd15403  169 VFFVPFSIMLYSYLCIL------------NTVRRNAVRIHNHADSLclsqvsKLGLMGLQRPHQMNV-----DMSFKTRA 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKrVFGmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15403  232 FTTILILFVGFSLCWLPHTVFSLLS-VFS--RRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
63-365 1.66e-17

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 82.54  E-value: 1.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15386   17 GNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTYMLIMMTV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPElanrtrlfSVCDERWADDLYP---KIYHSC 218
Cdd:cd15386   97 DRYIAVCHPLrTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQG--------SGVLDCWADFGFPwgaKAYITW 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvRNWKRPSdQLGDLEQGLSGEPQPRARafLAEVKQM-RARRKTA 297
Cdd:cd15386  169 TTLSIFVLPVAILIVCYSLICYEIC------------KNLKGKT-QTSRSEGGGWRTQGMPSR--VSSVRTIsRAKIRTV 233
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 298 KMLMVVLLVFALCYLPI------SVLNVlkrvfgmfrQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 365
Cdd:cd15386  234 KMTFVIVLAYIACWAPFfsvqmwSVWDE---------NAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
63-369 2.14e-17

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 82.11  E-value: 2.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15317   17 GNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLaimvpqaavMECSSVLPELANRTRLfsvcdERWADDlyPKIYHSCFF 220
Cdd:cd15317   97 DRYYAVCDPLRYpsKITVQVAWRFIAIGWLVPG---------IYTFGLIYTGANDEGL-----EEYSSE--ISCVGGCQL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IV----------TYLAPLGLMAMAYFQIFrklwgrqipgttsALVRNWKRPSDQLGDLEQGLSGEPQPRARaflaevkqm 290
Cdd:cd15317  161 LFnkiwvlldflTFFIPCLIMIGLYAKIF-------------LVARRQARKIQNMEDKFRSSEENSSKASA--------- 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 291 RARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15317  219 SRERKAAKTLAIVMGIFLFCWLPYFIDTIVDEYSNFITPA----IVFDAVI---WLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
63-373 4.50e-17

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 80.64  E-value: 4.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK---VIPYLqavSVSVAVLTLSF 139
Cdd:cd15295   17 GNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVfwlVIDYL---LCTASVYNIVL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFK---STARRARGSILGIWAvsLAIMVPQAAVMECSSVLPELanrtrlfSVCDERWADDLYpkiYH 216
Cdd:cd15295   94 ISYDRYQSVSNAVSYRnqqTATLRIVTQMVAVWV--LAFLVHGPAILVSDSWKTED-------GECEPEFFSNWY---IL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRArRKT 296
Cdd:cd15295  162 AITSVLEFLVPVILVAYFNTQIYWSLW--------------------------------------------KRLRD-RKL 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 297 AKMLMVVLLVFALCYLPISvlnvlkrVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAF 373
Cdd:cd15295  197 AKSLAIILGTFAICWAPYS-------LFTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
63-369 6.06e-17

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 80.09  E-value: 6.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15331   17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAI-CHPLLFKSTARRARGSILGIWAVSLAIMVPQaavmecssvlpelanrtrLFSVCDERWADDLY---------P 212
Cdd:cd15331   97 DRYWAVtNIDYIRRRTAKRILIMIAVVWFVSLIISIAP------------------LFGWKDEDDLDRVLktgvclisqD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 213 KIYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqMRA 292
Cdd:cd15331  159 YGYTIFSTVGAFYVPLLLMIIIYWKIYQA------------------------------------------------AKR 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 293 RRKTAKMLMVVLLVFALCYLPISVLNVLKRvfgmFRQASDREAVYACFTFshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15331  191 ERKAARTLAIITGAFVVCWLPFFLVALVMP----FCGAWQISRFLESFFL--WLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 9.24e-17

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 80.33  E-value: 9.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15977   17 GNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSI--LGIWAVSLAIMVPQAAVMEcssvLPELANRTRLFSVCderwaddLYPKIYHSCFf 220
Cdd:cd15977   97 DRYRAVASWSRIRGIGIPVWKAVevTLIWAVAIIVAVPEAIAFD----MVEIDYRGQTLLVC-------MLPMEQTSSF- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 ivtylaplglmaMAYFQIFRKLWgrqIPGTTSALvrnwkrPSDQLGDLEQGLSGEPQPRARAF-LAEVKQMRARRKTAKM 299
Cdd:cd15977  165 ------------MRFYQDVKDWW---LFGFYFCL------PLACTGVFYTLMSCEMLSIKNGMrIALNDHMKQRREVAKT 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVfgmfrqASDREAVYACFTFSHWLVY---------ANSAANPIIYNFLSGKFREQF 369
Cdd:cd15977  224 VFCLVVIFALCWLPLHLSRILKKT------IYDVKDPQRCELLSFLLVMdytginmasLNSCINPVALYFVSRKFKNCF 296
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-366 1.42e-16

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 79.46  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15132   17 GNTMTVLIIRRYKDMRTTTNLYLSSMAVSD-LLILLCLPFDLYrLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPQAAVMECSSvlPELANRTRLFSVCDERWADdLYPKIYHSCF 219
Cdd:cd15132   96 IERYLAICFPLRAKvlVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQ--DNNIHPDDFSRECKHTPYA-VSSGLLGIMI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVT--YLAPLGLMAMAYFQIFRKLWG--RQIPGTTSALvrnwkrpsdqlgdleqglsgepqpraraflaevkQMRARRK 295
Cdd:cd15132  173 WVTTtyFFLPMLCLSFLYGFIGRKLWKskNDLRGPNAAA----------------------------------RERSHRQ 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVLkrvfgmFRQASDreavYACFTFSHW-------LVYANSAANPIIYNFLSGKFR 366
Cdd:cd15132  219 TVRILAVVVLAFIICWLPFHIGRIL------FANTED----YRTMMFSQYfnivamqLFYLSASINPILYNLISRKYR 286
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
63-358 1.82e-16

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 79.15  E-value: 1.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSF 139
Cdd:cd15006   16 GNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFCSVTVLSFAA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPelanrtrlFSVCDERWADDLYPKIYHSCF 219
Cdd:cd15006   96 IALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYA--------MSTCTESWGYSLGHLVYVIIY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNwkrpsdqlgdleqglsgepqPRARAFLAEVKQMRArrKTAKM 299
Cdd:cd15006  168 NITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRT--------------------PQNTISIPYVSQREA--ELHAM 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGmfrqaSDREAVYACFTfSHWLVYANSAANPIIY 358
Cdd:cd15006  226 LLSMVLVFILCSVPYATLVIYRTILN-----ISDISVFLLLT-AIWLPKVSLLANPLLF 278
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
64-373 2.31e-16

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 78.43  E-value: 2.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15335   18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRlfsvcderwADDLYPKIYHSC--F 219
Cdd:cd15335   98 RYWAITDAIEYarKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQ---------HDHVIYTIYSTFgaF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIvtylaPLGLMAMAYFQIFrklwgrqipgttSALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmraRRKTAKM 299
Cdd:cd15335  169 YI-----PLTLILILYYRIY------------HAASR------------------------------------ERKAARI 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 300 LMVVLLVFALCYLP--ISVLNVLKRVFGMFRQASDreavyacftFSHWLVYANSAANPIIYNflsgKFREQFKAAF 373
Cdd:cd15335  196 LGLILGAFILSWLPffIKELIVGLSVMTVSPEVAD---------FLTWLGYVNSLVNPLLYT----SFNEDFKLAF 258
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
69-369 3.08e-16

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 78.30  E-value: 3.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  69 LAVWRNHhmrtvtNYFIVNLSLADVLVtAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYA 147
Cdd:cd15199   29 LKVWKPY------AVYLLNLVLADVLL-LICLPFKAYFYLNgNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 148 ICHPLLFKS--TARRARGSILGIWAVSLAIMVPqaavmecSSVLPELANRTRLFSVcdERWADDLYPKIYHSCFFIVTYL 225
Cdd:cd15199  102 VVHPRGKKNslSLQAAPYISFLVWLLLVGLTIP-------TLLASQPKNFTECNSF--SPKDDEDFSDTWQEAVFFLQFL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 226 APLGLMAMAYFQIFRKLwgrqipgttsalvrnWKRPSDQlgdleqglsgEPQPRAraflaevkqmrarRKTAKMLMVVLL 305
Cdd:cd15199  173 LPFGLIVFCTVRIIRRL---------------KKRLRDV----------GKQPKL-------------QRAMALVTSVVV 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 306 VFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15199  215 VFGFCFLPCFLARVLMLIFQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
63-375 3.77e-16

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 78.02  E-value: 3.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15305   17 GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASIMHLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARG--SILGIWAVSLAIMVPQAAVmecssvlpELANRTRLFSVCDERWADDLYPKIYHscf 219
Cdd:cd15305   97 LDRYVAIRNPIEHSRFNSRTKAmmKIAAVWTISIGISMPIPVI--------GLQDDEKVFVNGTCVLNDENFVLIGS--- 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 fIVTYLAPLGLMAMAYFQifrklwgrqipgTTSALVRnwkrpsdqlgdlEQGLSGEpqpraraflaevkqmrarRKTAKM 299
Cdd:cd15305  166 -FVAFFIPLIIMVITYCL------------TIQVLQR------------QQAINNE------------------RRASKV 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 300 LMVVLLVFALCYLPISVLNVLkrvFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSC 375
Cdd:cd15305  203 LGIVFFLFLIMWCPFFITNIL---SVLCKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
63-369 3.91e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 78.36  E-value: 3.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15400   17 GNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRaRGSILG---IWAVSLAIMVPQAAVmecssvlPELANRTRLFSVCDERWADDLYPkiyhSCF 219
Cdd:cd15400   97 NRYCYICHSFAYDKLYSR-WNTLLYvclIWALTVVAIVPNFFV-------GSLEYDPRIYSCTFVQTASSSYT----IAV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFrkLWGRQIPGTTSALVRNWKRPSDqlgdleqglsgepqprARAFLAevkqmrarrktakm 299
Cdd:cd15400  165 VVIHFIVPITVVSFCYLRIW--VLVIQVRRKVKSESKPRLKPSD----------------FRNFLT-------------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPisvLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15400  213 MFVVFVIFAICWAP---LNLIGLAVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 4.00e-16

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 78.28  E-value: 4.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15209   17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGS--ILGIWAVSLAIMVPQAAVmecssvlPELANRTRLFSVCDERWADdlypKIYHSCFF 220
Cdd:cd15209   97 NRYCYICHSLQYDRLYSLRNTCcyLCLTWLLTVLAVLPNFFI-------GSLQYDPRIYSCTFAQTVS----TVYTITVV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQIPgttsalVRNWKRPSDQLGDLeqglsgepqpraRAFLaevkqmrarrktakML 300
Cdd:cd15209  166 VIHFLLPLLIVSFCYLRIWVLVLQVRQR------VKPDQRPKLKPADV------------RNFL--------------TM 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVyacFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15209  214 FVVFVLFAVCWAPLNFIGLAVAINPKEMAPKIPEWL---FVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
63-369 5.36e-16

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 77.33  E-value: 5.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15330   17 GNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaavmecssvlPELANRT----RLFSVCdeRWADDLYPKIYH 216
Cdd:cd15330   97 DRYWAITDPIDYvnKRTPRRAAVLISLTWLIGFSISIP-----------PMLGWRTpedrSDPDAC--TISKDPGYTIYS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 S--CFFIvtylaPLGLMAMAYFQIFRklwgrqipgttsALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmraRR 294
Cdd:cd15330  164 TfgAFYI-----PLILMLVLYGRIFK------------AAAR------------------------------------ER 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLkrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15330  191 KTVKTLGIIMGTFILCWLPFFIVALV-----LPFCESTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
63-369 9.01e-16

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 77.25  E-value: 9.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15402   17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVmecssvlPELANRTRLFSVCDERWADDLYpkIYHSCFF 220
Cdd:cd15402   97 NRYCYICHSLKYDKlySDKNSLCYVLLIWVLTVAAIVPNLFV-------GSLQYDPRIYSCTFAQSVSSAY--TIAVVFF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 ivTYLAPLGLMAMAYFQIfrklWGRQIpgTTSALVRNWKRPSDQLGDLeqglsgepqpraRAFLAevkqmrarrktakmL 300
Cdd:cd15402  168 --HFILPIIIVTFCYLRI----WILVI--QVRRRVKPDNKPKLKPHDF------------RNFVT--------------M 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 301 MVVLLVFALCYLPISVLNVlkrvfgmfRQASDREAVYA-----CFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15402  214 FVVFVLFAVCWAPLNFIGL--------AVAVDPETIVPripewLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
63-369 1.26e-15

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 76.55  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd17790   17 GNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLLIISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanRTRLFSVCDERWADDlyPKIYHSCFF 220
Cdd:cd17790   97 DRYFSITRPLTYraKRTPRRAAIMIGLAWLISFVLWAP--AILFWQYLVGE---RTVLAGQCYIQFLSQ--PIITFGTAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLaPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaEVKQmrarRKTAKML 300
Cdd:cd17790  170 AAFYL-PVTIMIILYWRIYRE--------------------------------------------TIKE----KKAARTL 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd17790  201 SAILLAFILTWTPYNIMVLVS----TFCKDCVPKTLW---ELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
64-367 1.33e-15

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 76.76  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCkvipYLQAVSVS----VAVLTLSF 139
Cdd:cd15082   31 NFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWAC----VLEGFAVTffgiVALWSLAV 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPelanrTRLFSVCDERW-ADDLYPKIYHS 217
Cdd:cd15082  107 LAFERFFVICRPLgNIRLQGKHAALGLLFVWTFSFIWTIP--PVLGWSSYTV-----SKIGTTCEPNWySGNMHDHTYII 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGDLEQglsgepqprARaflaevkqmRARRKTA 297
Cdd:cd15082  180 TFFTTCFILPLGVIFVSYGKLLQKL----------------RKVSNTQGRLGN---------AR---------KPERQVT 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFtfshwlvyANSAA--NPIIYNFLSGKFRE 367
Cdd:cd15082  226 RMVVVMIVAFMVCWTPYAAFSILVTAHPTIHLDPRLAAIPAFF--------SKTAAvyNPIIYVFMNKQFRK 289
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
63-375 2.02e-15

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 76.02  E-value: 2.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARG--SILGIWAVSLAIMVPqaavMECSSVLPELANRTRLFSVCD-ERWADDLypkIYHSc 218
Cdd:cd15306   97 LDRYIAIKKPIQASQYNSRATAfiKITVVWLISIGIAIP----VPIKGIETDVDNPNNITCVLTkERFGDFI---LFGS- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 ffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdLEQGLSGEpqpraraflaevkqmrarRKTAK 298
Cdd:cd15306  169 --LAAFFTPLAIMIVTYFLTIHAL-------------------------RKQTITNE------------------QRASK 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVFGmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSC 375
Cdd:cd15306  204 VLGIVFFLFLLMWCPFFITNITSVLCD----SCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
68-366 3.04e-15

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 75.50  E-value: 3.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  68 CLAVW---RNHHMRTVTNYFIVNLSLADVLVTaICLPasLLVDIT---ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15160   19 CLALWvlyLQIKKENVLGVYLLNLSLSDLLYI-LTLP--LWIDYTanhHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVslaIMVPQAAVMECSSVLPELANRTRlfsvCDERWADDLYPKIYHSCF 219
Cdd:cd15160   96 VDRYLAVVHPLRFRGlrTRRFALKVSASIWVL---ELGTHSVFLGHDELFRDEPNHTL----CYEKYPMEGWQASYNYAR 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSAlvrnwkrpsdqlgdleqglsgepqpraraflaevkqmrARRKTAKM 299
Cdd:cd15160  169 FLVGFLIPLSLILFFYRRVLRAV--RQSPSLERE--------------------------------------EKRKIIGL 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGMFRQA--SDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15160  209 LLSIVVIFLLCFLPYHVVLLVRSVIELVQNGlcGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVR 277
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
63-366 8.12e-15

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 74.40  E-value: 8.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLP---ASLLVDitESWLFGHALCKVIPYLQAVSVSVAVLTLSF 139
Cdd:cd15193   17 GNLFVIALMSKRSTTKRLVDTFVLNLAVAD-LVFVLTLPfwaASTALG--GQWLFGEGLCKLSSFIIAVNRCSSILFLTG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPqaavmecSSVLPELANRtrlfSVCDERWADDLYPKIYHS 217
Cdd:cd15193   94 MSVDRYLAVVKLLDSRplRTRRCALITCCIIWAVSLVLGIP-------SLVYRNLINE----SVCVEDSSSRFFQGISLA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIvTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraRAFLAEVKQMRARRKTA 297
Cdd:cd15193  163 TLFL-TFVLPLIVILFCYCSILVRLR-------------------------------------RHFHGAKRTGRRRRNSL 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVF--GMFRQASDRE-AVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15193  205 RIVFAIVTAFVLSWLPFNTLKAVRLLLelGGGVLPCHTTvAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
63-243 9.04e-15

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 74.15  E-value: 9.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15079   17 GNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQAAVMeCSSVLPElanrTRLFSVCDERWADDLYPKIYHSCFFI 221
Cdd:cd15079   96 DRYNVIVKPLnGNPLTRGKALLLILFIWLYALPWALLPLLFG-WGRYVPE----GFLTSCSFDYLTRDWNTRSFVATIFV 170
                        170       180
                 ....*....|....*....|..
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLW 243
Cdd:cd15079  171 FAYVIPLIIIIYCYSFIVKAVF 192
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
63-375 1.10e-14

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 73.83  E-value: 1.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15299   20 GNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRArGSILGI-WAVSLAIMVPQAAVMECSsvlpeLANRTrlfSVCDERWADDLYPKIYHSCF 219
Cdd:cd15299  100 DRYFSITRPLTYraKRTTKRA-GVMIGLaWVISFVLWAPAILFWQYF-----VGKRT---VPPDECFIQFLSEPIITFGT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaEVKQmrarRKTAKM 299
Cdd:cd15299  171 AIAAFYLPVTIMTILYWRIYKE--------------------------------------------TIKE----KKAAQT 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 300 LMVVLLVFALCYLPISVLnVLKRVFgmfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSC 375
Cdd:cd15299  203 LSAILLAFIITWTPYNIM-VLVNTF------CDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
63-369 1.19e-14

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 73.33  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15308   17 GNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGvWTLSPVLCDALMTMDVMLCTASIFNLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSIL--GIWAVSLAIMVPqaavmecssVLPELAN-RTRLFSVCdeRWADDLYpKIYHSc 218
Cdd:cd15308   97 VDRFIAVSVPLNYNRRQGSVRQLLLisATWILSFAVASP---------VIFGLNNvPNRDPAVC--KLEDNNY-VVYSS- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 ffIVTYLAPLGLMAMAYFQIFRKLwGRQipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmrarRKTAK 298
Cdd:cd15308  164 --VCSFFIPCPVMLVLYCAMFRGL-GRE-----------------------------------------------RKAMR 193
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKrvfGMFRQASDREAVYACFTfshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15308  194 VLPVVVGAFLFCWTPFFVVHITR---ALCESCSIPPQLISIVT---WLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
63-369 1.55e-14

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 73.69  E-value: 1.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTV--TNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd14976   17 GNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMYSSIFFLTAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLlfksTARRARGSiLGIWAVSLAIMVPQAAVmecssVLPELANRTRLFSVCDERWADDLYPK------- 213
Cdd:cd14976   97 SVTRYIAVARAL----KHGWIRKA-FGAFATTIAIWAAAALA-----AIPEAIFSTDTWSSVNHTLCLLRFPKnssvtrw 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 -----IYHSCFFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraFLAEVK 288
Cdd:cd14976  167 ynwlgMYQLQKVVLGFFLPLGIITLSYLLLLR------------------------------------------FLQRKR 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 QMRARRKT--AKMLMVVLLVFALCYLPISVLNvLKRVFGMFRQASDREAVYACFTF----SHWLVYANSAANPIIYNFLS 362
Cdd:cd14976  205 GGSKRRKSrvTKSVFIVVLSFFICWLPNQALS-LWSALIKFDDVPFSDAFFAFQTYafpvAICLAHSNSCLNPVLYCLVR 283

                 ....*..
gi 205804177 363 GKFREQF 369
Cdd:cd14976  284 REFRDAL 290
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
64-373 1.84e-14

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 73.06  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLLF--KSTARRARGSILGIWAVSLAIMvpqaavmecssvLPELANRTRLFSVCDERWA--DDLYPKIYHS-- 217
Cdd:cd15334   98 RYRAITDAVEYarKRTPKHAGIMIAVVWIISIFIS------------MPPLFWRHQTTSREDECIIkhDHIVFTIYSTfg 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIvtylaPLGLMAMAYFQIFRklwgrqipgttsALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmraRRKTA 297
Cdd:cd15334  166 AFYI-----PLALILILYYKIYR------------AATR------------------------------------ERKAA 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREavyacfTFSHWLVYANSAANPIIYNFlsgkFREQFKAAF 373
Cdd:cd15334  193 TTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMS------NFLTWLGYINSLINPLIYTI----FNEDFKKAF 258
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
63-369 2.19e-14

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 73.36  E-value: 2.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHA-----LCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15975   17 GNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFDDSsfgvfLCKLVPFLQKASVGITVLNL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAIchpllfkSTARRARGS---------ILGIWAVSLAIMVPQAAVMecssVLPELANRTRLFSVCDERWAD 208
Cdd:cd15975   97 CALSVDRYRAV-------ASWSRVQGIgiplitaieIFSIWVLSFILAIPEAIGF----VMVPFEYNGEQYRTCMLNATT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 D---LYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvRNwkrpsdqlGDLEQGLSgepqprarafla 285
Cdd:cd15975  166 KfmnFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCEMLNR----------RK--------GSLRIALS------------ 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 286 evKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgMFRQASDREAVYACFT-----FSHWLVYANSAANPIIYNF 360
Cdd:cd15975  216 --EHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKT--VYNENDPRRCELLSFLlvmdyISINLATMNSCINPIALYF 291

                 ....*....
gi 205804177 361 LSGKFREQF 369
Cdd:cd15975  292 VSKKFKNCF 300
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
63-365 2.78e-14

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 72.54  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLAD--VLVTAiclPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15121   17 GNLFVVWSVLCRMKKRSVTCILVLNLALADaaVLLTA---PFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFK--STARRARGSILGIWAVSLAIMVPqaaVMECSSVLPELANrtrlFSVCDERwaddlYPKIYHSC 218
Cdd:cd15121   94 SMDRCLAVAKPFLSQkmRTKRSVRALLLAIWIVAFLLSLP---MPFYRTVLKKNIN----MKLCIPY-----HPSVGHEA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FF-----IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFlaevkqmRAR 293
Cdd:cd15121  162 FQylfetITGFLLPFTAIVTCYSTIGRRL------------------------------------RSARF-------RRK 198
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 294 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSH---WLVYANSAANPIIYNFLSGKF 365
Cdd:cd15121  199 RRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKAAKLARPnvtALAFLSSSVNPVLYAFAGGSL 273
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
63-369 4.31e-14

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 72.88  E-value: 4.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15005   17 GNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMAsVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPqaavmecssvlPELANRTRLFSVCDERWA-DDLYPKIYHSC 218
Cdd:cd15005   97 VTRYMAIAHHRFYAKrmTFWTCLAVICMAWTLSVAMAFP-----------PVFDVGTYTFIREEDQCTfEHRSYKANDTL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIF------RKL------------WGRQIPGTTSALVRNWK-------RPSDQLGDLEQGLS 273
Cdd:cd15005  166 GFMLVLAVVIAATHLVYLKLLiflrhhRKMkpaqlvpaisqnWTFHGPGATGQAAANWTagfgrgpTPPTLLGIRQAFHS 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 274 GEpqpRARAFLAEVKQmraRRKTAKMLMVVLLVFALCYLPISVLNVLkRVFgmfrqaSDREAVYACF-TFSHWLVYANSA 352
Cdd:cd15005  246 GA---RRLLVLDEFKM---EKRLTRMFYAITLLFLLLWSPYIVACYI-RVF------VRGYAVPQGFlTAAVWMTFAQAG 312
                        330
                 ....*....|....*..
gi 205804177 353 ANPIIYNFLSGKFREQF 369
Cdd:cd15005  313 VNPIVCFFFNRELRKCL 329
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
63-368 4.50e-14

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 72.15  E-value: 4.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHmRTVTNYFIVNLSLADvLVTAICLPASL--LVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15339   17 GNILVLFTIIRSRK-KTVPDIYVCNLAVAD-LVHIIVMPFLIhqWARGGE-WVFGSPLCTIITSLDTCNQFACSAIMTAM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPllFKSTARRARGSI----LGIWAVSLAIMVPqaaVMECSSVLPELANrtrlFSVC--DERWADD-LYPK 213
Cdd:cd15339   94 SLDRYIALVHP--FRLTSLRTRSKTirinLLVWAASFILVLP---VWVYAKVIKFRDG----LESCafNLTSPDDvLWYT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYHScffIVTYLAPLGLMAMAYFQIFRKLWgrqipgttSALVRNWKrpsdqlgdleqglsgepqprARAFLAEVKQMRAR 293
Cdd:cd15339  165 LYQT---ITTFFFPLPLILICYILILCYTW--------EMYRKNKK--------------------AGRYNTSIPRQRVM 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 294 RKTaKMLMVVLLVFALCYLPISVLNVLKrvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15339  214 RLT-KMVLVLVGVFLVSAAPYHVIQLVN-----LSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKR 282
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
63-369 4.96e-14

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 72.09  E-value: 4.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15191   17 GNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLFASIFFITCMSV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF-KSTARRARGSILGIWavslaimvpqaaVMECSSVLPELANRTRLF------SVCDERWADDLYPKIY 215
Cdd:cd15191   97 DRYLAVVYPLRSqRRRSWQARLVCLLVW------------VLACLSSLPTFYFRDTYYieelgvNACIMAFPNEKYAQWS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFF---IVTYLAPLGLMAMAYFQIFRKLWGRQIPGttsalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRA 292
Cdd:cd15191  165 AGLALmknTLGFLIPLIVIATCYFGIGRHLLKTKGFG--------------------------------------KNKQR 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 293 RRKTAKMLMVVLLVFALCYLPISVLNVLK--RVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15191  207 RDKVLKMVAAVVLAFLICWFPFHVLTFLDalARMGVINNCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 7.18e-14

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 71.78  E-value: 7.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGH-----ALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15128   17 GNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGDqpfgqFLCKLVPFIQKASVGITVLNL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAIchpllfkSTARRARG---------SILGIWAVSLAIMVPQAAVMecssVLPELANRTRLFSVC---DER 205
Cdd:cd15128   97 CALSVDRYRAV-------ASWSRIQGigipmwtavEIVMIWMLSAVLAVPEAIGF----DMVRFNYKGVTLRTCllrPET 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 206 WADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIfrklwgrqipgtTSALVRNWKrpsdqlGDLEQGLSgepqprarafla 285
Cdd:cd15128  166 SFMKFYIDVKDWWLFGFYFCLPLVCTAIFYTLM------------TCEMLRKRN------GMLRIALN------------ 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 286 evKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVfgMFRQASDREAVYACFT-----FSHWLVYANSAANPIIYNF 360
Cdd:cd15128  216 --EHLKQRREVAKTVFCLVVIFALCWLPLHLSRILKLT--VYDQNDPNRCELLSFLlvldyFGINLATLNSCINPIALYF 291

                 ....*....
gi 205804177 361 LSGKFREQF 369
Cdd:cd15128  292 VSRKFKNCF 300
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
63-363 1.57e-13

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 70.59  E-value: 1.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14975   17 GNSFVIWSILIKVKQRSVTMLLVLNLALADLAVL-LTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPQAAVMECSSvlpelanrTRLFSVCDERWADDLYpKIYHSCF- 219
Cdd:cd14975   96 ERFLAVSRPFVSQGWRAKalAHKVLAIIWLLAVLLATPVIAFRHVEE--------TVENGMCKYRHYSDGQ-LVFHLLLe 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFlaevkqmRARRKTAKM 299
Cdd:cd14975  167 TVVGFAVPFTAVVLCYSCLLRRL------------------------------------RRRRF-------RRRRRTGRL 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVF----GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSG 363
Cdd:cd14975  204 IASVVVAFAACWLPYHVGNLLEVVSeligGSKMAGTLGKVAEAGRPIAGALAFLSSSINPLLYAFAAR 271
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
63-369 2.20e-13

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 69.92  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVclAVWRNHHMR--TVTNYFIVNLSLADVLVtAICLPASLLVDI---------TESWLFGhALCKVIPYLQAVSVS 131
Cdd:cd15137   17 GNLFV--LIWRLKYKEenKVHSFLIKNLAIADFLM-GVYLLIIASVDLyyrgvyikhDEEWRSS-WLCTFAGFLATLSSE 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 132 VAVLTLSFIALDRWYAICHPLLF-KSTARRARGSILGIWAVSLAImvpqaavmecsSVLPELANRT-RLF----SVCDER 205
Cdd:cd15137   93 VSVLILTLITLDRFICIVFPFSGrRLGLRRAIIVLACIWLIGLLL-----------AVLPLLPWDYfGNFygrsGVCLPL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 206 WADDLYPK--IYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgTTSALVRNWKRPSDqlgdleqglsgepqpraRAF 283
Cdd:cd15137  162 HITDERPAgwEYSVFVFLGLNFLAFVFILLSYIAMFISIR------RTRKAAASRKSKRD-----------------MAV 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 284 laevkqmrARRktakMLMVVLLVFaLCYLPISVLNVLkrvfGMFRQASDREaVYAcftfshWLVY----ANSAANPIIYN 359
Cdd:cd15137  219 --------AKR----FFLIVLTDF-LCWIPIIVIGIL----ALSGVPIPGE-VYA------WVAVfvlpINSALNPILYT 274
                        330
                 ....*....|
gi 205804177 360 FLSGKFREQF 369
Cdd:cd15137  275 LSTPKFRKKL 284
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
63-369 2.38e-13

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 70.60  E-value: 2.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVW----RNHHMRTVTNYfIVNLSLADVLVTAICLPASLLVDITE--SWLFGHALCKVIPYLQAVSVSVAVLT 136
Cdd:cd15135   17 GNSATIKVTQvlqkKGYLQKSVTDH-MVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIYNFLFEACSYATILN 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 137 LSFIALDRWYAICHPLLFKS-TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDE----------- 204
Cdd:cd15135   96 VATLSFERYIAICHPFKYKAlSGSRVRLLICFVWLTSALVALPLLFAMGTEDPLEAFPSYRGTRHHCQDqksnltictsl 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 205 --RWAddLYPKIYHSCFfiVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwkrpsdQLGDLEQGLSGEPQPRARA 282
Cdd:cd15135  176 ssKWT--VFQASIFSAF--VLYLLVLASVAFMCRRMMRALMGSKKGAVAVK----------GPGGSVQLLRKHESAEGKT 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 283 flaevkqmrARRKTAKMLMVVLLVFALCYLPisvlNVLKRVFGMFRQASDREAVY-----ACFTFSHWLVYANSAANPII 357
Cdd:cd15135  242 ---------ARKQTILFLGLIVGTLAVCWMP----NQIRRIMAAAKPKDDWTRSYfrayiILLPIADTFFYLSSVLNPLL 308
                        330
                 ....*....|..
gi 205804177 358 YNFLSGKFREQF 369
Cdd:cd15135  309 YNLSSQQFRSVF 320
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
63-369 2.66e-13

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 69.79  E-value: 2.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVW---RNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSF 139
Cdd:cd15154   14 GLLLNAVALWvfvRYLRLHSVVSIYMCNLALSDLLFT-LSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPQAAVMECSSVLpelaNRTRLFSVCDERWADDLYPKIYHS 217
Cdd:cd15154   93 INVDRYLAIVHPLRFRHLRRPkvARLLCLAVWALILGGSVPAAIVHSSSDCL----LHGEKVYRCFESFSDNDWKGLLPL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFF--IVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmraRRK 295
Cdd:cd15154  169 VVLaeILGFLLPLAAVLYCSCRIFVELCRTQEPQQGR----------------------------------------RRK 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 296 TAKMLMVVLLVFALCYLPisvLNVLKRVFGMFR------QASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15154  209 TVRLLLVNLVIFLICFVP---YNTTLAVYGLLRanlvedTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
63-369 2.87e-13

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 69.41  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15173   17 GNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLF--LCTLPFWAYSAAHEWIFGTVMCKITNGLYTINLYSSMLILTCITV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS-TARRAR-GSI--LGIWAVSLAIMVPQAAVmecsSVLPELANrtrlfSVCDERWADDLYPKIYHSC 218
Cdd:cd15173   95 DRFIVIVQATKAHNcHAKKMRwGKVvcTLVWVISLLLSLPQFIY----SEVRNLSS-----KICSMVYPPDAIEVVVNII 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFlaevkqmrARRKTAK 298
Cdd:cd15173  166 QMTVGFFLPLLAMIICYSVIIKTLL-----------------------------------HAKGF--------QKHKSLK 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVFGMFR-QASDREAVyacfTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15173  203 IIFVVVAVFILTQLPYNIMKLIRTLHIENTdSTNFKYAI----LITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-369 3.78e-13

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 69.59  E-value: 3.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTN---YFIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15130   17 GNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPVELynFIWVHHPWAFGDAGCRGYYFLRDACTYATALNV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSvlpELANRTRLFSVCDERWADDLYPKIY 215
Cdd:cd15130   97 ASLSVERYLAICHPFKAKTlmSRSRTKKFISAIWLASALLAIPMLFTMGLQN---ESDDGTHPGGLVCTPIVDTATLKVV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqMRARRK 295
Cdd:cd15130  174 IQVNTFMSFLFPMLVTSILNTVIANKL-----------------------------------------------VQALRR 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHW-------LVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15130  207 GVLVLRAVVIAFVVCWLPYHVRRL------MFCYISDEQWTTFLFDFYHYfymltnaLFYVSSAINPILYNLVSANFRQV 280

                 .
gi 205804177 369 F 369
Cdd:cd15130  281 F 281
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
63-369 4.50e-13

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 69.08  E-value: 4.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15301   17 GNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVP---QAAVMECSSVLPelanrtrlfsvcderwADDLYPKIYHS 217
Cdd:cd15301   97 DRYFSVTRPLTYraRRTTKKAAVMIASAWIISLLLWPPwiySWPYIEGKRTVP----------------AGTCYIQFLET 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIV--TYLA----PLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflAEVKQMR 291
Cdd:cd15301  161 NPYVTfgTALAafyvPVTIMCILYWRIWRE-------------------------------------------TKKRQKK 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFgmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15301  198 QESKAAKTLSAILLAFIVTWTPYNVLVLIKAFF-----PCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
63-369 4.58e-13

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 69.01  E-value: 4.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITeSWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15181   17 GNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLT-FPFSVVESIA-GWVFGTFLCKLVGAIHKLNFYCSSLLLACISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfkSTARRARG-----SILGIWAVSLAIMVPQAAVMECSSvlPELANRTRL----FSVCDERWADDLYPK 213
Cdd:cd15181   95 DRYLAIVHAI---HSYRHRRLrsvhlTCGSIWLVCFLLSLPNLVFLEVET--STNANRTSCsfhqYGIHESNWWLTSRFL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYHSCFFIvtylaPLGLMAMAYFQIFRklwgrqipgttsALVRNWKRPSDQlgdleqglsgepqpraraflaevkqmrar 293
Cdd:cd15181  170 YHVVGFFL-----PLLIMGYCYATIVV------------TLCQSSRRLQKQ----------------------------- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 294 rKTAKMLMVVLLVFALCYLP---ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15181  204 -KAIRVAILVTLVFCLCWLPyniVIFLDTLDDLKAVVKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
63-369 6.11e-13

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 68.74  E-value: 6.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRN---HHMRTVTNYFIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15356   17 GNALTIHLVLKKrslRGLQGTVHYHLVSLALSDLLILLISVPIELynFVWFHYPWVFGDLVCRGYYFVRDICSYATVLNI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVM------ECSSVLPELANRtrlfsVCDERWADD 209
Cdd:cd15356   97 ASLSAERYLAICQPLRAKRllSKRRTKWLLALIWASSLGFALPMAFIMgqkyelETADGEPEPSSR-----VCTVLVSRA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 210 LYpKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkQ 289
Cdd:cd15356  172 TL-KVFIQVNAFVSFVLPLALIAFLNGVTVSHL----------------------------------------------R 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 290 MRARRKTAKMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHW-------LVYANSAANPIIYNFLS 362
Cdd:cd15356  205 IQSLQHSVQVLRAIVIAYVICWLPYHARRL------MFCYVPDDAWTDSLYNFYHYfymltntLFYVSSAVNPLLYNVVS 278

                 ....*..
gi 205804177 363 GKFREQF 369
Cdd:cd15356  279 SSFRKLF 285
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
84-369 6.43e-13

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 68.63  E-value: 6.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVtAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTARR 160
Cdd:cd15162   38 YMANLAIADLLL-VIWLPFKIAYHIHGNnWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIVHPMghRRLRARRY 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 161 ARGSILGIWAVSLAIMVP-----------QAAVMECSSVLPElanrtrlfsvcDERWADDLYpkiYHSCFFIVTYLAPLG 229
Cdd:cd15162  117 ALGTCLAIWLLALLVTLPlylvkqtiflpALDITTCHDVLPE-----------QLLVGDWFY---YFLSLAIVGFLIPFI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 230 LMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqLGDLEQGLSGEPQPRAraflaevkqmrarrktAKMLMVVLLVFAL 309
Cdd:cd15162  183 LTASCYVATIRT-----------------------LAALEDENSEKKKKRA----------------IKLAATVLAIFII 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 310 CYLPIsvlNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15162  224 CFAPS---NLLLLAHYSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
63-369 1.10e-12

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 67.89  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15296   17 GNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLISY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF---KSTARRARGSILGIWAVSLAIMVPQAAVMEC---SSVLPElanrtrlfsvcderwaDDLYPKIYH 216
Cdd:cd15296   97 DRFLSVTRAVSYraqKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYiagGSIIPE----------------GECYAEFFY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVT-----YLAPlgLMAMAYFQifrklwgrqipgttsalvrnwkrpsdqlgdleqgLSGEPQPRARAFlaevkQMR 291
Cdd:cd15296  161 NWYFLMTastleFFTP--FISVTYFN----------------------------------LSIYLNIQKRRF-----RLS 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNVLkrvfgmfRQASDREAV-YACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15296  200 RDKKVAKSLAIIVCVFGLCWAPYTLLMII-------RAACHGHCVpDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
63-365 1.26e-12

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 67.91  E-value: 1.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLV--CLAVWRNHHMRTVTNYFIVNLSLADVLVTAIClPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15122   17 GNGFIiwSILWKMKARGRSVTCILILNLAVADGAVLLLT-PFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFIIGLM 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPQAAVMEcssVLPELANRTRlfsVCDERWADDLYpKIYHSC 218
Cdd:cd15122   96 SLDRCLAVTRPYLAQSLRKKalVRKILLAIWLLALLLALPAFVYRH---VWKDEGMNDR---ICEPCHASRGH-AIFHYT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 F-FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFlaevkqmRARRKTA 297
Cdd:cd15122  169 FeTLVAFVLPFGVILFSYSVILVRL------------------------------------KGARF-------RRRARVE 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFR---QASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 365
Cdd:cd15122  206 KLIAAIVVAFALLWVPYHVVNLLQVVANLAPgevLEKLGGAAKAARAGATALAFFSSSVNPLLYVFAAGDL 276
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
63-368 1.29e-12

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 68.25  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMR-TVTNYFIVNLSLADvLVTAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15190   27 GNGLVLWTVFRSKRKRrRSADTFIANLALAD-LTFVVTLPLwAVYTALGYHWPFGSFLCKLSSYLVFVNMYASVFCLTGL 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLlfKSTARRARGSIL----GIWAVSLAIMVPqAAVMECSSVLpELANRTRL---FSVCDERWADDLYPK 213
Cdd:cd15190  106 SFDRYLAIVRSL--ASAKLRSRTSGIvalgVIWLLAALLALP-ALILRTTSDL-EGTNKVICdmdYSGVVSNESEWAWIA 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqprARAF-LAEVKQMRA 292
Cdd:cd15190  182 GLGLSSTVLGFLLPFLIMLTCYFFIGRTV-------------------------------------ARHFsKLRRKEDKK 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 293 RRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFR---QASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15190  225 KRRLLKIIITLVVTFALCWLPFHLVKTLYALMYLGIlpfSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
63-366 1.52e-12

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 67.45  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15073   17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF-KSTARRARGSILGIW--AVSLAIMvpqaAVMECSSVLPELANRTrlfsvCDERWA--DDLYPKIYHS 217
Cdd:cd15073   97 DRYLTICRPDLGrKMTTNTYTVMILLAWtnAFFWAAM----PLVGWASYALDPTGAT-----CTINWRknDSSFVSYTMS 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CfFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWkrpSDQlgdleqglsgepqpraraflaevkqmrarRKTA 297
Cdd:cd15073  168 V-IVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDW---TDQ-----------------------------NDVT 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 298 KMLMVVLLVFALCYLPISVLNvlkrVFGMFRQASDREAVYACFTfshwLVYANSAA--NPIIYNFLSGKFR 366
Cdd:cd15073  215 KMSVIMIVMFLVAWSPYSIVC----LWASFGEPKKIPPWMAIIP----PLFAKSSTfyNPCIYVIANKKFR 277
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
63-369 1.86e-12

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 67.43  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15161   17 GNTLALWLFIHDRKSGTPSNVFLMHLAVAD-LSYVLILPMRLVYHLSGNhWPFGEVPCRLAGFLFYLNMYASLYFLACIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTaRRAR------GSILGIWAVSLAIMVPQAAVME------CSSVLPELANRTRLFSVcderwadd 209
Cdd:cd15161   96 VDRFLAIVHPVKSMKI-RKPLyahvvcGFLWVIVTVAMAPLLVSPQTVEvnnttvCLQLYREKASRGALVSL-------- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 210 lypkiyhscffIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdlEQGLSGEPqpraraflaevkq 289
Cdd:cd15161  167 -----------AVAFTIPFVTTVTCYLLIIRSL--------------------------RTGKREEK------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 290 mRARRKTAKMLMVVLLVFALCYLP--ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15161  197 -PLKDKAIKMIILVLTIFLICFVPyhISRYIYILSHNGAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRE 275

                 ..
gi 205804177 368 QF 369
Cdd:cd15161  276 TL 277
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
63-147 1.92e-12

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 67.57  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15127   17 GNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTFTLCALCI 96

                 ....*
gi 205804177 143 DRWYA 147
Cdd:cd15127   97 DRFRA 101
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
63-178 2.14e-12

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 66.89  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15214   16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAI 95
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVP 178
Cdd:cd15214   96 DRYYAVLYPMVYpmKITGNRAVLALVYIWLHSLIGCLP 133
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
63-179 3.61e-12

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 66.81  E-value: 3.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15126   17 GNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTSLGVTTFSLCALGI 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 205804177 143 DRWYAICHPLLFKSTARRARgSILG----IWAVSLAIMVPQ 179
Cdd:cd15126   97 DRFHAATSPQPKARPVERCQ-SILAklavIWVGSMTLAVPE 136
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
69-369 4.79e-12

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 66.09  E-value: 4.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  69 LAVWR-NHHMR--TVTNYFIVNLSLADVLVTaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 144
Cdd:cd15377   20 VAIWMfVFHMKpwSGISVYMFNLALADFLYV-LTLPALIFYYFNKTdWIFGDAMCKLQRFIFHVNLYGSILFLTCISVHR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 145 WYAICHPLlfKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTrlfSVCDERWADDLYPK--IYHSCFFIV 222
Cdd:cd15377   99 YTGVVHPL--KSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKT---ITCYDTTSDEYLRSyfIYSMCTTVA 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLWGRQIPGTtsalvrnwkrpsdqlgdleqglsgepqpraraflaEVKQMRARRKTAKMLMV 302
Cdd:cd15377  174 MFCVPFILILGCYGLIVRALIYKDMKYT-----------------------------------EENNAPLRRKSIYLVII 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 303 VLLVFALCYLPISVLNVLKRVFGMFRQASD----REAVYACFTFSHWLVYANSAANPIIYnFLSG-KFREQF 369
Cdd:cd15377  219 VLTVFAVSYLPFHVMKTLNLRARLDFQTPAmcafNDRVYATYQVTRGLASLNSCVDPILY-FLAGdTFRRRL 289
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
80-364 9.36e-12

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 65.16  E-value: 9.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  80 VTNYFIVNLSLADVLVtAICLPasLLV---DITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LF 154
Cdd:cd15373   34 ASTTYMFNLAISDTLY-VLSLP--LLVyyyADENDWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVCYPVrsLR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 155 KSTARRARGSILGIWAVSLAImvpQAAVMECSSVLPELANRTrlfsvCDERWADDLYPK--IYHSCFFIVTYLAPLGLMA 232
Cdd:cd15373  111 WLKVRYARIVSVVVWVIVLAC---QSPVLYFVTTSDKGGNIT-----CHDTSSPELFDQfvVYSSVMLVLLFCVPFVVIL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 233 MAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepQPRARAflaeVKQMRARRKTAKMLMVVLLVFALCYL 312
Cdd:cd15373  183 VCYALMVRKLL---------------------------------KPSAGT----STNSRSKKKSVKMIIIVLAVFILCFL 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 205804177 313 PISVLNVLKRVF-GMFRQASDREAVYACFTFSHWLVYANSAANPIIYnFLSGK 364
Cdd:cd15373  226 PFHVTRTLYYSFrSMDLSCGTLNAINLAYKVTRPLASANSCLDPILY-FLAGQ 277
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
63-369 9.64e-12

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 65.15  E-value: 9.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15192   17 GNSLVVIVIYCYMKLKTVANIFLLNLALAD-LCFLITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNLYASVFLLTCLS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLlfKSTARR----ARGSILGIWAVSLAIMVPqaAVMECSSVLPELANRTrlfsVCDERwaddlYPKIYHS 217
Cdd:cd15192   96 IDRYLAIVHPM--KSRLRRtlvvARVTCIVIWLLAGVASLP--AIIHRDVFFIENTNIT----VCAFH-----YPSQNST 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFF-------IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqprARAFlaEVKQM 290
Cdd:cd15192  163 LLVglglmknLLGFLIPFLIILTCYTLIGKAL-------------------------------------KKAY--EIQRN 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 291 RARRKTA-KMLMVVLLVFALCYLPISVLNVLKRVFGM--FRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15192  204 KPRNDEIfKMIMAVVLFFFFCWIPHQIFTFLDVLIQLkvIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRK 283

                 ..
gi 205804177 368 QF 369
Cdd:cd15192  284 KF 285
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
84-368 1.23e-11

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 64.77  E-value: 1.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRA 161
Cdd:cd15372   37 FLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTlrSRRFA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 162 RGSILGIWAVSLAIMVPqAAVMECSSVLPELaNRTRLFSVCDERwADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRk 241
Cdd:cd15372  117 LCMCTAIWLIAAALTLP-LTLQRQSYPLERL-NITLCHDVLPLD-EQDTYLFYYFACLAVLGFLLPLVVILFCYGSVLH- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 242 lwgrqipgttsALVRNWKRPSDQLgdleqglsgepqpraraflaevkqmrarrktaKMLMVVLLVFALCYLPIsvlNVLK 321
Cdd:cd15372  193 -----------TLLRSGQRYGHAM--------------------------------KLTVLVLVSFVLCFTPS---NLLL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 205804177 322 RVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15372  227 LLHYSDPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDK 273
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
84-365 1.58e-11

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 64.69  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVTaICLP--ASLLVDiTESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTAR 159
Cdd:cd15201   38 YLFNLAVADFLLI-ICLPfrTDYYLR-GKHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHhrINSISVR 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 160 RARGSILGIWAVSLAIMV---------PQAAVMECSSvlpelanrtrlFSVCDERWADDlypkIYHSCFFIVTYLAPLGL 230
Cdd:cd15201  116 KAAIIACGLWLLTIAMTVylltkkhlfPRGNATQCES-----------FNICTGTDSSS----NWHEAMFLLEFFLPLAI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 231 MAMAYFQIFRKLWGRQIpgttsalvrnwkrpsDQLGDLeqglsgepqpraraflaevkqmrarRKTAKMLMVVLLVFALC 310
Cdd:cd15201  181 ILYCSVRIIWQLRGRQL---------------DRHAKI-------------------------KRAVQFIMVVAIVFIIC 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 311 YLPISVLNVL---KRVFGMFRQASDREAVYACFTfSHWLVYANSAANPIIYNFLSGKF 365
Cdd:cd15201  221 FLPSNVTRIAiwiLKHTSNEDCQYYRSVDLAFYI-TISFTYFNSMLDPVVYYFSSPSF 277
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
63-369 1.86e-11

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 64.37  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15087   17 GNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLV-LPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVMSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARR----ARGSILGIWAVSLAIMVPQAAVMECSSvlPELANRTRLFSVcdeRWADDLYPKIYHSC 218
Cdd:cd15087   96 DRYLVVLATVRSRRMPYRtyraAKIVSLCVWLLVTIIVLPFTVFAGVYS--NELGRKSCVLSF---PSPESLWFKASRIY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALvrnwkrpsdqlgdleqglsgepqpraraflaevkqMRARRKTAK 298
Cdd:cd15087  171 TLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKAL-----------------------------------DKAKKKVTL 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 299 MLMVVLLVFALCYLPISvlnvLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15087  216 MVLVVLAVCLFCWTPFH----LSTVVALTTDLPQTPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
63-369 2.24e-11

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 63.93  E-value: 2.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMR-TVTNYFIVNLSLADVLVtAICLPASLLVDITESWLFGHALCKVIPY-LQAVSVSVAVLTLSFI 140
Cdd:cd15104   16 GNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLV-GLAIPGLATDELLSDGENTQKVLCLLRMcFVITSCAASVLSLAAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFK--STARRARGSILGIWAVSLAI-MVPQAAVMECSSVLPELAnrtRLFSVCDERwaddlypkiYHS 217
Cdd:cd15104   95 AFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGLIgFLPLISPQFQQTSYKGKC---SFFAAFHPR---------VLL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvrnwkrpSDQLGDLEQglSGEPQPRARAFLAEVKQMRArrkta 297
Cdd:cd15104  163 VLSCMVFFPALLLFVFCYCDILKIARVH----------------SRAIYKVEH--ALARQIHPRRTLSDFKAART----- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 298 kmLMVVLLVFALCYLPISVLnvlkrvfGMFRQASDREAVYACFTFSHWLV-YANSAANPIIYNFLSGKFREQF 369
Cdd:cd15104  220 --VAVLIGCFLLSWLPFQIT-------GLVQALCDECKLYDVLEDYLWLLgLCNSLLNPWIYAFWQKEVRRAL 283
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
63-371 4.47e-11

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 63.64  E-value: 4.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVcLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:PHA03087  57 GNIIV-IYVLTKTKIKTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSV 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILG--IWAVSLAIMVPQAAVMECSSVLPELAnrtrlfsVCDERWADDLYPKIYHSCFF 220
Cdd:PHA03087 135 DRYIAIVHPVKSNKINTVKYGYIVSlvIWIISIIETTPILFVYTTKKDHETLI-------CCMFYNNKTMNWKLFINFEI 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 -IVTYLAPLGLMAMAYFQIFRKLWGRQIPgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKM 299
Cdd:PHA03087 208 nIIGMLIPLTILLYCYSKILITLKGINKS------------------------------------------KKNKKAIKL 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 300 LMVVLLVFALCYLP--ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKA 371
Cdd:PHA03087 246 VLIIVILFVIFWLPfnVSVFVYSLHILHFKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKK 319
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
63-369 4.51e-11

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 63.06  E-value: 4.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15297   17 GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMEC---SSVLPELANRTRLFSvcderwaddlYPKIYHS 217
Cdd:cd15297   97 DRYFCVTKPLTYpvKRTTKMAGMMIAAAWVLSFILWAPAILFWQFivgGRTVPEGECYIQFFS----------NAAVTFG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLaPLGLMAMAYFQIfrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqprARAFLAEvkqmrarRKTA 297
Cdd:cd15297  167 TAIAAFYL-PVIIMTVLYWQI-----------------------------------------SRASSRE-------KKVT 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYacfTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15297  198 RTILAILLAFIITWTPYNVMVLIN----TFCASCIPNTVW---TIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
63-369 5.38e-11

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 63.21  E-value: 5.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVcLAVWRNHHMRTVTNYFIVNLSLADVLVTAIcLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15117   17 GNGLV-IWVTGFRMTRTVTTVCFLNLAVADFAFCLF-LPFSVVyTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLIS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVP----QAAVMECSSVLPELA----NRTRlfsvcdERWadDLY 211
Cdd:cd15117   95 LDRCVSVLWPVWARNhrTPARAALVAVGAWLLALALSGPhlvfRDTRKENGCTHCYLNfdpwNETA------EDP--VLW 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 212 PKIYHSCF-------FIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsalvrnwkrpsdqlgdleqglsgepqprarafl 284
Cdd:cd15117  167 LETVVQRLsaqvitrFVLGFLVPLVIIGGCYGLIAARLWREGW------------------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 285 aevkqMRARRKTaKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGK 364
Cdd:cd15117  210 -----VHSSRPF-RVLTAVVAAFFLCWFPFHLVSLLELVVILNQKEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRD 283

                 ....*
gi 205804177 365 FREQF 369
Cdd:cd15117  284 FRERL 288
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
63-367 5.51e-11

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 62.95  E-value: 5.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15316   17 GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVC----DERWAddlypkiyH 216
Cdd:cd15316   97 DRYIAVTDPLVYptKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEELVNALNCVGGCqiilNQNWV--------L 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIvtYLAPLGLMAMAYFQIF--RKLWGRQIPGTTSALVRNWKRPSDQLGdleqglsgepqpraraflaevkqmRARR 294
Cdd:cd15316  169 VDFLL--FFIPTFAMIILYGKIFlvAKQQARKIEMTSSKAESSSESYKDRVA------------------------RRER 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQAsdreavyACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15316  223 KAAKTLGITVIAFLVSWLPYLIDVLIDAFMNFITPP-------YIYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
63-373 5.79e-11

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 62.51  E-value: 5.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15054   17 GNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVISL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVS-LAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCf 219
Cdd:cd15054   97 DRYLLIISPLRYKLrmTPPRALALILAAWTLAaLASFLPIELGWHELGHERTLPNLTSGTVEGQCRLLVSLPYALVASC- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 fiVTYLAPLGLMAMAYfqifrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqprARAFLAEVKQMRARRktakM 299
Cdd:cd15054  176 --LTFFLPSGAICFTY--------------------------------------------CRILLAARKALKASL----T 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKrvfgmfrqasdreAVYAC-----FTFSHWLVYANSAANPIIYNFlsgkFREQFKAAF 373
Cdd:cd15054  206 LGILLGMFFVTWLPFFVANVVQ-------------AVCDCvspglFDVLTWLGYCNSTMNPIIYPL----FMRDFKRAL 267
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
63-367 6.57e-11

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 62.58  E-value: 6.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVcLAVWRNHHMRTVT--NYFIVNLSLADvLVTAICLP---ASLLVDITesWLFGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15925   17 GNLAV-MYLLRNCARRAPPpiDVFVFNLALAD-FGFALTLPfwaVESALDFH--WPFGGAMCKMVLTATVLNVYASVFLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLL--FKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPElanrtrlfSVCDERWADDLYPKIY 215
Cdd:cd15925   93 TAMSVTRYWVVASAAGpgTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGV--------ELCLLKFPSNYWLGAY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIpgttsalvrNWKRPSDQlgdleqglsgepqpraraflaevkqmrarRK 295
Cdd:cd15925  165 HLQRVVVAFVVPLGVITTSYLLLLSFLQQHKV---------NQNNRQRQ-----------------------------SV 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLnVLKRVFGMFRQASDREAVYACFTF----SHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15925  207 IARSVRLVVASFFLCWFPNHVV-TFWGVLVKFRAVPWNSTFYFIHTYvfpvTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
63-369 7.82e-11

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 62.47  E-value: 7.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAiCLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15172   17 GNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVL-TLPF-WAVYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL----LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSvlpelaNRTRLFSVCDERWADDLYPKIYHSC 218
Cdd:cd15172   95 DRYIAIVQATksfrLRSRTLAYSKLICAAVWLLAILISLPTFIFSEVYD------FGLEEQYVCEPKYPKNSTAIMWKLL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVT----YLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFlaevkqmrARR 294
Cdd:cd15172  169 VLSLQvslgFFIPLLVMIFCYSFIIKTLL-----------------------------------QAQNS--------QRH 205
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVLKR-VFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15172  206 KAVRVVVAVVLVFLVCQVPYNIVLLIEAiNLGEQQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
63-369 9.37e-11

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 62.14  E-value: 9.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMR---TVTNYFIVNLSLADVLvtaICLPASLLVDI---TESWLFGHALCKVIPYLQAVSVSVAVLT 136
Cdd:cd15338   17 GNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLL---FLLGMPFLIHQllgNGVWHFGETMCTLITALDTNSQITSTYI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 137 LSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVP----------QAAVMECSSVLPELANRTRLFSvcde 204
Cdd:cd15338   94 LTVMTLDRYLATVHPIRSTKirTPRVAVAVICLVWILSLLSITPvwmyaglmplPDGSVGCALLLPNPETDTYWFT---- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 205 rwaddLYPkiyhscfFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALvrnwkrpsdqlgdleqglsgepqprarafl 284
Cdd:cd15338  170 -----LYQ-------FFLAFALPLVVICVVYFKILQNMASTVAPLPQRSL------------------------------ 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 285 aevkQMRARRKTaKMLMVVLLVFALCYLPISVLNVLKRVFgmfrQASDREAVYAcFTFSHWLVYANSAANPIIYNFLSGK 364
Cdd:cd15338  208 ----RVRTKKVT-RMAVAICLAFFICWAPFYILQLAHLSI----DRPSLAFLYA-YNVAISMGYANSCINPFLYIMLSET 277

                 ....*
gi 205804177 365 FREQF 369
Cdd:cd15338  278 FKRQF 282
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
63-369 9.52e-11

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 61.97  E-value: 9.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15300   17 GNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASVMNLLVISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRArGSILGI-WAVSLAIMVPqaaVMECSSVLpeLANRTRLFSVCDERWaddLYPKIYHSCF 219
Cdd:cd15300   97 DRYFSITRPLTYraKRTPKRA-GIMIGLaWLISFILWAP---PILCWQYF--VGKRTVPERECQIQF---LSEPTITFGT 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaEVKQmrarRKTAKM 299
Cdd:cd15300  168 AIAAFYIPVSVMTILYCRIYKE--------------------------------------------TIKE----RKAAQT 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 300 LMVVLLVFALCYLPISVLnVLKRVFgmfrqaSDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15300  200 LSAILLAFIITWTPYNIM-VLVSTF------CSDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
3-366 9.85e-11

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 63.11  E-value: 9.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177   3 PSATPGAQMGVPPGSREPSPVPP------DYEDEF-----LRYLWRDYLYPKQYEWVLIAAYVAVFVVALvGNTLVCLAV 71
Cdd:PHA02638  45 PTEIPTSESPSPNSNSSSSSSSSsssityDYEYENnityeLINIKNKCMYPSISEYIKIFYIIIFILGLF-GNAAIIMIL 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  72 WrNHHMRTVTNYFIVNLSLADvLVTAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHP 151
Cdd:PHA02638 124 F-CKKIKTITDIYIFNLAISD-LIFVIDFPF-IIYNEFDQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYP 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 152 LLFKSTARRARGSILGI--WAVSLAIMVPQAAVMECSSVLPELANRTRLFS-----VCDERWADD--LYPKIYHSCFFIV 222
Cdd:PHA02638 201 ISFQKYRTFNIGIILCIisWILSLIITSPAYFIFEASNIIFSAQDSNETISnyqctLIEDNEKNNisFLGRILQFEINIL 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKMLMV 302
Cdd:PHA02638 281 GMFIPIIIFAFCYIKIILKL---------------------------------------------KQLKKSKKTKSIIIV 315
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 303 VLLVFA--LCYLPISVLNVLKRVFGMFRQAS-DREAVYACFTFSHWLVYANSAA------NPIIYNFLSGKFR 366
Cdd:PHA02638 316 SIIIICslICWIPLNIVILFATMYSFKGFNSiISEHICGFIKLGYAMMLAEAISlthcciNPLIYTLIGENFR 388
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
63-366 1.04e-10

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 62.29  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15074   17 GNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHP-LLFKSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPELANRTrlfsvCDERWA---DDLYPKIYHSC 218
Cdd:cd15074   97 YRYLKICHPpYGPKLSRRHVCIVIVAIWLYALFWAVA--PLVGWGSYGPEPFGTS-----CSIDWTgasASVGGMSYIIS 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKRPSDQLGDLEQglsgepqpraraflaevKQMRARRKTAK 298
Cdd:cd15074  170 IFIFCYLLPVLIIVFSYVKIIRK-------------VKSSRKRVAGFDSRSK-----------------RQHKIERKVTK 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFtfshwlvYANSAA--NPIIYNFLSGKFR 366
Cdd:cd15074  220 VAVLICAGFLIAWTPYAVVSMWS-AFGSPDSVPILASILPAL-------FAKSSCmyNPIIYLLFSSKFR 281
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
82-367 1.66e-10

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 61.45  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  82 NYFIVNLSLADvLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLlfKSTARR 160
Cdd:cd15926   37 NLFVTSLAVTD-FQFVLTLPFWAVENALDfTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASAL--KSKRRR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 161 ARGSI----LGIWAVSLAIMVPQAAVMECSSVLPELANrtrLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYF 236
Cdd:cd15926  114 GCCSAkwlcVLIWVLAILASLPNAIFSTTATVSNEELC---LVKFPDNRGNAQFWLGLYHAQKVLLGFLIPLGIISLCYL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 237 QIFRKLWGRQIPGTTSalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKMLMVVLLVFALCYLPISV 316
Cdd:cd15926  191 LLVRFITDKNITGSST--------------------------------------KRRSKVTKSVTIVVLSFFLCWLPNQA 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 317 LN----VLKRVFGMFRQASDREAVYAcFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15926  233 LTtwgiLIKLNVVHFSYEYFTTQVYI-FPITVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
63-183 1.88e-10

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 61.12  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15232   17 GNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAY 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 205804177 143 DRWYAICHPLLFKSTARRAR--GSILGIWAVSLAIMVPQAAVM 183
Cdd:cd15232   97 DRYVAICHPLHYSTIMRKEVcvGLATGVWAIGMLNSAVHTGLM 139
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
63-369 2.29e-10

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 60.94  E-value: 2.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd14988   17 ENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVV-LTLPVWMLeVMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCLS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMEcssvLPELANRTRLFSVCDERWaDDLYPKIYHSCf 219
Cdd:cd14988   96 VDRYLTLTSSSPFwqQHQHRIRRALCAGIWVLSAIIPLPEVVHMQ----LLDGVEPMCLFLAPFETY-DEWALAVSLLT- 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLwgRQipgttsalvrnwkrpsdqlgdleqglSGEPQPRARAFLaevkqmrarrktakm 299
Cdd:cd14988  170 LIIGFLIPFSIIAVFNVLTARYI--RT--------------------------AGRPESRRHCLL--------------- 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 300 LMVVLLVFALCYLPISVLNVLKRVFGM--FRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd14988  207 IYAYILVFVVCWLPYHVTLLLLTLHGShiSLHCNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-366 2.55e-10

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 60.94  E-value: 2.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15189   17 GNLFVLLVFLLHRRRLTVAEIYLGNLAAAD-LVFVSGLPFWAMNILNQfNWPFGELLCRVVNGVIKVNLYTSIYLLVMIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPqAAVMECSSVLPELANRTRLFSVCDERWaddlypKIYHSCF 219
Cdd:cd15189   96 QDRYLALVKTMAARRLRRRryAKLICVLIWVVGLLLSIP-TFLLRKIKAIPDLNITACVLLYPHEAW------HFAHIVL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 F-IVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvrnwkrpsdqlgdlEQGLsgepqpraraflaevKQMRARRKTAK 298
Cdd:cd15189  169 LnIVGFLLPLLVITFCNYNILQALRTRE----------------------ESTR---------------CEDRNDSKATA 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVF--GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15189  212 LVLAVTLLFLVCWGPYHFFTFLDFLFdvGVLDECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
63-366 3.89e-10

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 60.23  E-value: 3.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAiCLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15186   17 GNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVA-TLPFWTHYLINE-WGLHNAMCKLTTAFFFIGFFGGIFFITVISI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQAAVM-----ECSSVLPELANrtrlfsvcderwadDLYPKIY 215
Cdd:cd15186   95 DRYLAIVLAAnsMNNRTVQHGVTISLGVWAAAILVAVPQFMFTkmkenECLGDYPEVLQ--------------EIWPVLR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqgLSGEPQPRARAFlaevkqmrarrk 295
Cdd:cd15186  161 NVELNFLGFLLPLLIMSYCYFRIIQTL-----------------------------FSCKNHKKARAI------------ 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 296 taKMLMVVLLVFALCYLPISVLNVLK--RVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15186  200 --KLILLVVIVFFLFWTPYNVMIFLEtlKLYDFFPSCDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
63-366 4.31e-10

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 60.17  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15177   17 GNGLVLATHTRYRRLRSMTDVYLLNLALADLLL-LLTLPF-AAAETLQGWIFGNAMCKLIQGLYAINFYSGFLFLTCISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL----LFKSTARRARGSILGIWAVSLAIMVPQ---------AAVMECSSVLPELANRTRlfsvcderwadd 209
Cdd:cd15177   95 DRYVVIVRATsahrLRPKTLFYSVLTSLIVWLLSILFALPQliysrvenrSELSSCRMIFPEVVSRTV------------ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 210 lyPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGrqipgttsalVRNWKrpsdqlgdleqglsgepqpraraflaevkq 289
Cdd:cd15177  163 --KGATALTQVVLGFAIPLIVMAVCYAAIGRTLLA----------ARGWE------------------------------ 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 290 mraRRKTAKMLMVVLLVFALCYLPISVLNVLKR---VFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15177  201 ---RHRALRVIAALVVAFVLFQLPYSVVLLLDTadlLATLELSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
79-364 6.03e-10

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 59.79  E-value: 6.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  79 TVTNYFIVNLSLADvLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFK 155
Cdd:cd15968   33 TRTAIYMVNLALAD-LLYALSLPLLIYNYAMRDrWLFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMrpWHK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 156 STARRARGSILGIWAVSLAIMVPQAAVMECSSVlpelANRTrlfsVCDERWADDLYPK--IYHSCFFIVTYLAPLGLMAM 233
Cdd:cd15968  112 ETRRAAWLTCVLVWILVFAQTLPILIFARTGII----RNRT----VCYDLAPPALFPHyvPYGMALTVSGFLLPFSIILW 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 234 AYFQIFRKLWgRQIPGttsalvrnwkrpsdqlgdleqglsgepqpraraflAEVKQMRARRKTAKMLMVVLLVFALCYLP 313
Cdd:cd15968  184 CYCLVVRTLC-RTLGP-----------------------------------AEPPAQARRRKSIRTIVTVTLLFALCFLP 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 205804177 314 ISVLNVLKRVFGMFRQASDR--EAVYACFTFSHWLVYANSAANPIIYnFLSGK 364
Cdd:cd15968  228 FHITRTIYLAVRVTPGVPCHvlEAVAACYKITRPLASANSVLNPLLY-FLTKK 279
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
63-369 6.72e-10

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 59.82  E-value: 6.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtaIC-LPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15921   17 GNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL--VCtLPLRLTYYVLNShWPFGDIACRIILYVLYVNMYSSIYFLTAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHP--LLFKSTARRARGSILGIWAVslaIMVPQAAVMECSSVLPElANRTRLFSVCDERWAddlYPKIYHSC 218
Cdd:cd15921   95 SVFRYLALVWPylYLRVQTHSVAGIICGLIWIL---MGLASSPLLFAKSKQHD-EGSTRCLELAHDAVD---KLLLINYV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIfrklwgrqipgttsalVRNWKRPSDQLGdleqglsgepqpraraflaevKQMRARRKTAK 298
Cdd:cd15921  168 TLPVGFVVPFMTVIFCYIFI----------------IKNLLKPSPALG---------------------RTRPSRRKACA 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 299 MLMVVLLVFALCYLPISVLNV--LKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15921  211 LIIISLGIFLVCFLPYHIVRTihLITERQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
63-369 7.18e-10

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 59.40  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15368   17 GNLFSLWLLCFHTKPKTPSIIFMINLSLTD-LMLACFLPFQIVYHIQRNhWIFGKPLCNVVTVLFYANMYSSILTMTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPQAA-----------VMECSSVLpelaNRTRLFSVcdERWAD 208
Cdd:cd15368   96 IERYLGVVYPMRSMRWRKKryAVAACIGMWLLVLTALSPLERtdltyyvkelnITTCFDVL----KWTMLPNI--AAWAA 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 DLYpkiyhsCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaLVRNWKRpsdqlgdleqglSGEPQPRARAFLAevk 288
Cdd:cd15368  170 FLF------TLFILLFLIPFIITVYCYVLIILK------------LVQTSER------------YGREQKRRAIYLA--- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 qmrarrktakmlMVVLLVFALCYLPISVLNVLKRVFGMFRQASdreaVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15368  217 ------------LIVLLVFITCFAPNNFILLAHMVSRLFYGKS----LYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKK 280

                 .
gi 205804177 369 F 369
Cdd:cd15368  281 L 281
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
84-367 7.65e-10

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 59.43  E-value: 7.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADvLVTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF-KSTARRA 161
Cdd:cd15370   38 YMANLALAD-LLFVIWFPLKIAYHINgNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHsRKKANIA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 162 RGSILGIWAVSLAIMVP-----------QAAVMECSSVLPElanrtRLFSvcderwaddLYPKIYHSCFFIVTYLAPLGL 230
Cdd:cd15370  117 IGISLAIWLLILLVTIPlylvkqtvfipALDITTCHDVLPE-----QLLV---------GDMFNYFLSLAIGVFLFPAFL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 231 MAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraRAFLAEVKQMRARRKTAKMLMVVLLVFALC 310
Cdd:cd15370  183 TAVAYVLMIRAL--------------------------------------KSSINDESIEKKRKRAIKLIVTVLVMYLIC 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 311 YLPIsvlNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15370  225 FTPS---NLLLVVHYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRD 278
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
64-367 7.78e-10

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 59.48  E-value: 7.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtAICLPASLLVDITESWLF-GHALCkvipYLQAVSVS----VAVLTLS 138
Cdd:cd15085   18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMM-ALCGTTIVTVTNYEGYFYlGDAFC----IFQGFAVNyfgiVSLWSLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 139 FIALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVpqAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYH- 216
Cdd:cd15085   93 LLAYERYNVVCKPMgGLKLSTKRGYQGLLFIWLFCLFWAV--APLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLILYFl 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIvtylaPLGLMAMAYFQIFRKLwgrqipgttsalvRNWKRPSDQLGdleqglsGEPQPraraflaevkqmRARRKT 296
Cdd:cd15085  171 MCFVI-----PVAIIGFSYGNVLRSL-------------HKLNKKIEQQG-------GKNCP------------EEEERA 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 297 AKMLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAvyacfTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15085  214 VIMVLAMVIAFLICWLPYTVFALIV-VVNPELSISPLAA-----TMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
63-367 9.57e-10

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 59.08  E-value: 9.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15404   17 GNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPlLFKSTARRARGSILGIWAVSLAIMVPQAAVMecssvlPELANRTRLfSVCDERWADDLYPKIYHSCFFIV 222
Cdd:cd15404   97 DRFLIIVQK-QDKLNPYRAKVLIAVSWAVSFCVAFPLAVGS------PDLQIPSRA-PQCVFGYTTNPGYQAYVILIMLI 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 223 TYLAPLGLMAMAYFQIFRKlwgrqipgttsalVRNWKrpsdqlgdleqglsgepqprARAFLAevkqmrarrktakmLMV 302
Cdd:cd15404  169 FFFIPFMVMLYSFMGILNT-------------VRSFK--------------------TRAFTT--------------ILI 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 303 VLLVFALCYLPISVLNVLKRVFGMFRQasdREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15404  202 LFIVFTVCWAPFTTYSLVATFNSHFYH---KHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFRD 263
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
64-375 1.32e-09

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 59.11  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15084   28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanrtRLFSVCDERW-ADDLYPKIYHSCFFI 221
Cdd:cd15084  108 RYLVICKPMgDFRFQQRHAVSGCAFTWGWSLLWTSP--PLFGWSSYVPE-----GLRTSCGPNWyTGGTNNNSYILALFV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraRAFLAEVKQ----MRARRKTA 297
Cdd:cd15084  181 TCFALPLSTIIFSYSNLLLTL--------------------------------------RAVAAQQKEsettQRAEKEVT 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLkrvfgmfrQASDREAVYACFTFSHWLVYANSAA--NPIIYNFLSGKFREQFKAAFSC 375
Cdd:cd15084  223 RMVIAMVMAFLICWLPYATFAMV--------VATNKDVVIQPTLASLPSYFSKTATvyNPIIYVFMNKQFRSCLLELLCC 294
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
63-369 1.45e-09

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 58.49  E-value: 1.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15298   17 GNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPqaAVMECSSVlpeLANRTRLFSVCDERWADDlyPKIYHSCFF 220
Cdd:cd15298   97 DRYFCVTKPLTYpaRRTTKMAGLMIAAAWVLSFVLWAP--AILFWQFV---VGKRTVPDNQCFIQFLSN--PAVTFGTAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLaPLGLMAMAYFQIfrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraFLAEVKQmrarRKTAKML 300
Cdd:cd15298  170 AAFYL-PVVIMTVLYIHI--------------------------------------------SLASARE----RKVTRTI 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKrvfgMFRQASDREAVYAcftFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15298  201 FAILLAFILTWTPYNVMVLVN----TFCQSCIPDTVWS---IGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
64-367 1.82e-09

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 58.30  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15078   18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTLTVLAYE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLLFKSTArrARGSILGIWAVSLAImvpqaavmecsSVLPELANRTRLFSV----CDERW-ADDLYPKIYHSC 218
Cdd:cd15078   98 RYIRVVHAKVVNFSW--SWRAITYIWLYSLAW-----------TGAPLLGWNRYTLEVhglgCSFDWkSKDPNDTSFVLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkRPSDQLGDLEQglsgepqprarafLAEVKQMRARRKTAK 298
Cdd:cd15078  165 FFLGCLVVPLGIMAYCYGHILYEI-----------------RMLRSVEDLQT-------------FQVIKILKYEKKVAK 214
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKrVFGMFRQASDREAVYACFtfshwLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15078  215 MCLLMISTFLICWMPYAVVSLLV-TSGYSKLVTPTIAIIPSL-----FAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
69-358 2.01e-09

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 58.17  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  69 LAVW-------RNHHMRTVtnyFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15376   20 LALWlfvtrerRPWHTGVV---FSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNLYGSIFFITCIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTAR--RARGSILGIWAVSLAIMVPqaaVMECSSVLPELANRTrlfsVCDERWADDLYPKIYHSCF 219
Cdd:cd15376   97 LNRYLGIVHPFFTRSHVRpkHAKLVSLAVWLLVAALSAP---VLSFSHLEVERHNKT----ECLGTAVDSRLPTYLPYSL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTY--LAPLGLMAMAYFQIFRKLWgrQIPGTTsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqMRARRKTA 297
Cdd:cd15376  170 FLAVVgcGLPFLLTLASYLAIVWAVL--RSPGIT--------------------------------------TLEKRKVA 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 205804177 298 KMLMVVLLVFALCYLPISVL---NVLKRVFGMFRQASDReaVYACFTFSHWLVYANSAANPIIY 358
Cdd:cd15376  210 ALVAVVVALYAVSFVPYHILrnlNLYRRLQWLKAAASLR--IYFAYQVTKGLVTLNMCIHPLLY 271
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
63-362 2.17e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 57.82  E-value: 2.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14964   15 GNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLTY 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTAR--RARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVcderwaddlypKIYHSCFF 220
Cdd:cd14964   95 HRYFALCGPLKYTRLSSpgKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICT-----------TIYLTWGF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 -IVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkRPSDQLGDLEQGLSGEPQPRAraflaevkqmrarrktAKM 299
Cdd:cd14964  164 lLVSFLLPLVAFLVIFSRIVLRL-----------------RRRVRAIRSAASLNTDKNLKA----------------TKS 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 300 LMVVLLVFALCYLPISVLNVLkrvfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362
Cdd:cd14964  211 LLILVITFLLCWLPFSIVFIL------HALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
63-368 2.54e-09

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 57.89  E-value: 2.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPAsLLVDITE--SWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15380   17 GNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPF-WAENIRNqfNWPFGNFLCRVISGVIKANLFISIFLVVAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFKSTARR--ARGSILGIWAVSLAIMVPqAAVMECSSVLPELAnrtrlFSVCDERWADDLYPKIYHSC 218
Cdd:cd15380   95 SQDRYRTLVHTMTSRRQRSRrqAQVICLLIWVFGGLLSIP-TFLFRSVKHVPDLN-----ISACILLFPHEAWHFARRVE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSAlvrnwKRPSDQlgdleqglsgepqpraraflaevkqmrarrKTAK 298
Cdd:cd15380  169 LNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRC-----GGLKDT------------------------------KATR 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVFGMfrqasdrEAVYACF---------TFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15380  214 LILTLVLMFLVCWTPYHFFAFLDFLFQV-------EVIQGCFweefidlglQLANFFAFANSCLNPVIYVFAGKLFRTK 285
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
63-178 2.82e-09

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 57.86  E-value: 2.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15179   17 GNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFV-LTLPF-WAVDAAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISL 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLlfKSTARR----ARGSILGIWAVSLAIMVP 178
Cdd:cd15179   95 DRYLAIVHAT--NSQRPRkllaEKVVYVGVWLPALLLTVP 132
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
63-369 3.71e-09

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 57.06  E-value: 3.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15302   17 GNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFyTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLIT 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKS--TARRARGSILGIWAV-----SLAIMVPQAAVMECSSVLPelanrtrlfsvcDERWADDLYPKI 214
Cdd:cd15302   97 IDRYCSVKIPAKYRNwrTPRKVLLIIAITWIIpallfFISIFGWQYFTGQGRSLPE------------GECYVQFMTDPY 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsalVRNwkrpsdqlgdleqglsgepqpRAraflaevkqmrarR 294
Cdd:cd15302  165 FNMGMYIGYYWTTLIVMLILYAGIYR--------------AAN---------------------RA-------------R 196
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 295 KTAKMLMVVLLVFALCYLPISVLNVlkrVFGMFRQASDREAVYacFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15302  197 KALRTITFILGAFVICWTPYHILAT---IYGFCEAPPCVNETL--YTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
68-366 3.76e-09

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 57.45  E-value: 3.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  68 CLAVWRNHHMRTVTNY-----FIVNLSLADVLVTaICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15147   19 CYVLWVFARLYPSKKLneikiFMVNLTIADLLFL-ITLPFWIVYYHNEgNWILPKFLCNVAGCLFFINTYCSVAFLGVIS 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSILG--IWAVSLAIMVPQAAVMECSSVLPELANRTRlfsvCDERWADDLYPKIYHSCF 219
Cdd:cd15147   98 YNRYQAVTRPIKTAQSTTRKRGIIISvaIWVIIVASASYFLFMDSTNTVKIDSGNFTR----CFEGYEKDNSKPVLIIHF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVtylaplGLMAMAYFQIFrklwgrqipgtTSALVrnwkrpsdqlgdLEQGLSGEPQPRARAflAEVKQmRARRktakM 299
Cdd:cd15147  174 III------GLFFLVFLLIL-----------VCNLV------------IARTLLSQPVQGQRN--AGVKR-RALW----M 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 300 LMVVLLVFALCYLP---------ISVLNVLKRVFGMFRQA-SDREAVYACftfshwLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15147  218 VCTVLAVFVICFVPhhvvqgpwtLAVLQQWRYWDCQFRQAlNDAHQITLC------LMSTNCVLDPVIYCFLTKKFR 288
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
64-366 4.51e-09

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 57.13  E-value: 4.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15076   18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanrtRLFSVCDERW--ADDLYPKIYHSCF- 219
Cdd:cd15076   98 RYIVICKPFgNFRFGSKHALGAVVATWIIGIGVSLP--PFFGWSRYIPE-----GLQCSCGPDWytVGTKYRSEYYTWFl 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleQGLSGEPQPRARAflaevkqMRARRKTAKM 299
Cdd:cd15076  171 FIFCFIVPLSIIIFSYSQLLGAL---------------------------RAVAAQQQESAST-------QKAEREVSRM 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 300 LMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15076  217 VVVMVGSFCLCYVPYAALAM------YMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
63-244 5.17e-09

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 56.69  E-value: 5.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTnyFIVNLSLADVLVTAICLPASLLVD--ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15220   16 GNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGILSSspFFLGVVFGEAECRVYIFLSVCLVSASILTISAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLF--KSTARRARGSILGIWAVSLAImvpqAAVMECSSVLPELANrTRLFSVCDERWADDLYPKIYHSC 218
Cdd:cd15220   94 SVERYYYIVHPMRYevKMTIGLVAAVLVGVWVKALLL----GLLPVLGWPSYGGPA-PIAARHCSLHWSHSGHRGVFVVL 168
                        170       180
                 ....*....|....*....|....*.
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWG 244
Cdd:cd15220  169 FALVCFLLPLLLILVVYCGVFKVFGG 194
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
78-369 5.64e-09

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 57.08  E-value: 5.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADVLVTAIcLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 156
Cdd:cd15116   31 KTVNTVWFLNLAVADFLFTFF-LPFSIAYTAMDFhWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQN 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 --TARRARGSILGIWAVSLAIMVPQAAVMECSSVLPElaNRTRLFSVCDERwADDLYPKIYhscffivtylaPLGLMAMA 234
Cdd:cd15116  110 hrSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNN--NKIICFNNFSLS-GDNSSPEVN-----------QLRNMRHQ 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 235 YFQIFRKLWGRQIPGTT-----SALVRNWKRPsdqlgdleqglsgepqpraraflaevkQMRARRKTAKMLMVVLLVFAL 309
Cdd:cd15116  176 VMTITRFLLGFLIPFTIiiccyAAIVLKLKRN---------------------------RLAKSSKPFKIIAAVIVTFFL 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 310 CYLPISVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15116  229 CWAPYHILNLLE----MEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
63-178 6.08e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 56.39  E-value: 6.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15215   16 GNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSV 95
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 205804177 143 DRWYAICHPLLFKSTARRARGSIL--GIWAVSLAIMVP 178
Cdd:cd15215   96 DRYLAIIHPLSYPTKMTPRRGYLLiyGTWIVSVLQSTP 133
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
78-368 7.97e-09

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 56.32  E-value: 7.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADvLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 156
Cdd:cd15115   31 RTVNTIWFLNLAVAD-LLCCLSLPFSIAHLLLNGhWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQN 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 --TARRARGSILGIWAVSLAIMVPqaaVMECSSVLPELaNRTRlfsvCDERwaddlYPKIYHSCFFIVTYLAPLGLMAMA 234
Cdd:cd15115  110 hrSVLLACLLCGCIWILALLLCLP---VFIYRTTVTDG-NHTR----CGYD-----FLVAITITRAVFGFLLPLLIIAAC 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 235 YFQIFRKLwgrqipgttsalvrnwkrpsdqlgdleqglsgepQPRARAFlaevkqmrARRKTAKMLMVVLLVFALCYLPI 314
Cdd:cd15115  177 YSFIAFRM----------------------------------QRGRFAK--------SQSKTFRVIIAVVVAFFVCWAPY 214
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 205804177 315 SVLNVLKrvfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15115  215 HIIGILS----LYGDPPLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
84-368 8.53e-09

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 56.31  E-value: 8.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVtAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKSTARR 160
Cdd:cd15369   38 YMLNLACADLLF-VLLLPFKIAYHFSGNdWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMqsLSWRTLRR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 161 ARGSILGIWAVSLAIMVPqAAVMECSSVLPELaNRTRLFSVCDERWADDLYpKIYHSCFFIVTYLAPLGLMAMAYFQIFR 240
Cdd:cd15369  117 ASFTCAAIWLLSIAGVVP-LLLSEQTIQIPDL-GITTCHDVLNEQLLMGYY-VYYFSIFSCLFFFVPLIITTVCYVSIIR 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 241 KLWGRQIPGttsalvrnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAKMLM--VVLLVFALCYLPISVLN 318
Cdd:cd15369  194 CLSSSSDVA-----------------------------------------NSSKKTRALFMavAVFCVFVICFGPTNVLL 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 205804177 319 VLKRVFgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15369  233 LAHYVR--FAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQKQ 280
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
81-368 1.03e-08

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 55.96  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  81 TNYFIVNLSLADVLVTaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL--LFKST 157
Cdd:cd15374   35 TTVYMFHLALSDTLYV-LSLPTLIYYYADHNhWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGICHPIraLRWVK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 158 ARRARGSILGIWAVSLAIMVPQAAVMECSsvlpelanRTRLFSVCDERWADDLYPKIYHSCFFIVTYL--APLGLMAMAY 235
Cdd:cd15374  114 PRHAYLICASVWLVVTVCLVPNLIFVTTS--------RKDNITLCHDTTRPEEFDHYVHYSSAVMVLLfgIPCLVIVVCY 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 236 FQIFRKLWGRQIPGttsalvrnwkrpsdqlgdleqglsgePQPRaraflaevkQMRARRKTAKMLMVVLLVFALCYLPIS 315
Cdd:cd15374  186 GLMARRLCKPRVGS--------------------------SRQQ---------GPSSKKRSLKTIIMVLTVFAICFVPFH 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 205804177 316 VLNVLKRVFGMFRQASDR-EAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15374  231 ITRTLYYVARLLKADCDTlNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRR 284
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
64-240 1.03e-08

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 55.93  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRT-VTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15219   17 NLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTAR-RARGSILGI-WAVSLAIMVPQAAV---------MECSSVLPELANRTRLfsvcderwaddly 211
Cdd:cd15219   97 DRWIAVVFPLSYTSKMRyRDAALMVGYsWLHSLTFSLVALFLswlgysslyASCTLHLPREEERRRF------------- 163
                        170       180
                 ....*....|....*....|....*....
gi 205804177 212 pKIYHSCFFIVTYLAPLGLMAMAYFQIFR 240
Cdd:cd15219  164 -AVFTAFFHAFTFLLSLLVLCVTYLKVLK 191
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
63-369 1.05e-08

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 55.87  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHmRTVTNYFIVNLSLADVLVtaiCLPASLL-VDITES--WLFGHALCKVIPYLQAVSVSVAVLTLSF 139
Cdd:cd15114   17 GNALVAWVTGFEAK-RSVNAVWFLNLAVADLLC---CLSLPILaVPIAQDghWPFGAAACKLLPSLILLNMYASVLLLTA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPlLFKSTARRARGSILG---IWAVSLAIMVPQAAVMEcssvLPELANRTRLfsVCDERWADDLYPKIYH 216
Cdd:cd15114   93 ISADRCLLVLRP-VWCQNHRRARLAWIAcgaAWLLALLLTVPSFIYRR----IHQEHFPEKT--VCVVDYGGSTGVEWAV 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCF-FIVTYLAPLGLMAMAYFQIFRKLWGRqipgttsalvRNWKRPsdqlgdleqglsgepqpraraflaevkqmrarrK 295
Cdd:cd15114  166 AIIrFLLGFLGPLVVIASCHGVLLVRTWSR----------RRQKSR---------------------------------R 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 296 TAKMLMVVLLVFALCYLPISVLNVlkrvfgMFRQASDREAVYACFTFSHWLV----YANSAANPIIYNFLSGKFREQF 369
Cdd:cd15114  203 TLKVVTAVVVGFFLCWTPYHVVGL------IIAASAPNSRLLANALKADPLTvslaYINSCLNPIIYVVAGRGFRKSL 274
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
63-368 1.17e-08

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 55.93  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVcLAVWRNHHMR-TVTNYFIVNLSLADvLVTAICLPA-SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15381   17 ENAFV-LIVFCLHKSScTVAEIYLGNLAAAD-LLLVCCLPFwAINISNGFNWPFGEFLCKSVNAVIYMNLYSSIYFLMMV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQaAVMECSSVLPELAnrtrlFSVCDERWADDLYPKIYHSC 218
Cdd:cd15381   95 SIDRYLALVKTMSSgrMRRPACAKLNCLIIWMFGLLMSTPM-IVFRTVMYFPEYN-----ITACVLDYPSEGWHVALNIL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvRNWKrpsdqlgdleqglsgepqprarafLAEVKQMRARRKTAK 298
Cdd:cd15381  169 LNVVGFLIPLSIITFCSTQIIQVL-------------RNNK------------------------MQKFKEIQTERKATV 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 205804177 299 MLMVVLLVFALCYLPISVLNVLKRVF--GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15381  212 LVLAVLLMFFICWLPFHIFTFLDTLHklGLISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
63-201 1.60e-08

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 55.52  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVcLAVWRNH-HMRTVTNYFIVNLSLADVLVTaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15176   17 GNSLV-VAIYAYYkKLKTKTDVYILNLAVADLLLL-FTLPF-WAADAVNGWVLGTAMCKITSALYTMNFSCGMQFLACIS 93
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVmecsSVLPELANRTRLFSV 201
Cdd:cd15176   94 VDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVF----STVRENSDRYRCLPV 149
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
77-369 2.24e-08

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 54.93  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  77 MRTVTNYFIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 156
Cdd:cd15155   31 MRNETAIFMTNLAVSD-LLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 TARRARGSIL--GIWAVSLAIMVpqaavmecSSVLPELANRTRLFSVCDERWADDLYPkiyhscffivTYLAPLglmama 234
Cdd:cd15155  110 IRTRRNSAIVcaGVWILVLSGGI--------SASLFSTTNVSNTSTTCFEGFSKSIWK----------TYLSKI------ 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 235 yfQIFRKLWGRQIP-----GTTSALVRNWKRPSD--QLGDleqglsgepqpraraflaevkqmrARRKTAKMLMVVLLVF 307
Cdd:cd15155  166 --TIFIEVVGFIIPlllnlTCSSLVLRTLRKPATlsQIGT------------------------NKEKVLKMILVHVAIF 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 308 ALCYLP---ISVLNVLKRVFGMFRQASDREAvYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15155  220 VVCFVPynsILFLYALVRSQAIANCGVERFA-RTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
62-369 2.27e-08

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 55.05  E-value: 2.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15159   16 LGNTLALHVICQKRKKINSTTLYLINLAVSDILFT-LALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAGVNFMTCL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQaavmecssVLPELANRTRLFSVCDErwaddlYP---KIY 215
Cdd:cd15159   95 SVDRYIAVVHPLRRhrLRKVKVVRYICVFVWVLVFLQTLPL--------LFMPMTKEMGGRITCME------YPnfeKIK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HSCFF-----IVTYLAPLGLMAMAYFQIfrklwgrqipgtTSALVRNWKrpSDQLGDlEQGLSgepqpraraflaevkqm 290
Cdd:cd15159  161 RLPLIllgacVIGFGVPVGIILFCYSQI------------TLKLCRTAK--ENPLTE-KSGHH----------------- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 291 rarRKTAKMLMVVLLVFALCYLPISVlNVLKRVFGMFRQASD---REAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15159  209 ---KKACNVILLVLLVFVVCFSPYHL-NIIQFMIRKLLYQPScseLKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKK 284

                 ..
gi 205804177 368 QF 369
Cdd:cd15159  285 KV 286
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
63-366 2.56e-08

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 54.81  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVL-VTAICLPASLLVDiteSWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15187   17 GNSLVIWVLVACKKLRSMTDVYLLNLAASDLLfVFSLPFQAYYLLD---QWVFGNAMCKIVSGAYYIGFYSSMFFITLMS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVP---------QAAVMECSSVLPELANRTRLFSvcderwaddl 210
Cdd:cd15187   94 IDRYLAIVHAVyaLKVRTASHGTILSLALWLVAILASVPllvfyqvasEDGRLQCIPFYPGQGNSWKVFT---------- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 211 ypkiyHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALvrnwkrpsdqlgdleqglsgepqpraraflaevkqm 290
Cdd:cd15187  164 -----NFEVNILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAI------------------------------------ 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 291 rarrktaKMLMVVLLVFALCYLPISVLNVLKRVFGM--FRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15187  203 -------KLVFIVVIVFFLFWTPFNVVLFLDSLHSLhiIDGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFK 273
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
78-184 3.56e-08

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 54.40  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADVLVTAIcLP---ASLLVDitESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLF 154
Cdd:cd15120   31 RTVNTLWFLHLILSNLIFTLI-LPfmaVHVLMD--NHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWS 107
                         90       100       110
                 ....*....|....*....|....*....|..
gi 205804177 155 KS--TARRARGSILGIWAVSLAIMVPQAAVME 184
Cdd:cd15120  108 RQhrTNRWASAIVLGVWISAILLSIPYLAFRE 139
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
63-366 3.79e-08

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 54.37  E-value: 3.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15174   17 GNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLF--LCTLPFWATAASSGWVFGTFLCKVVNSMYKINFYSCMLLLTCISV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKSTARR----ARGSILGIWAVSLAIMVPQ---------AAVMECSSVLP-ELANRTRLFSvcderwad 208
Cdd:cd15174   95 DRYIAIVQATKAHNSKNKrllySKLVCFFVWLLSTILSLPEilfsqskeeESVTTCTMVYPsNESNRFKVAV-------- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 dLYPKIyhscffIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdqlgdleqglsgepqpRARAFlaevk 288
Cdd:cd15174  167 -LALKV------TVGFFLPFVVMVICYTLIIHTLL-----------------------------------QAKRF----- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 qmrARRKTAKMLMVVLLVFALCYLP---ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKF 365
Cdd:cd15174  200 ---QKHKALKVIIAVVTVFVLSQLPynsILLIKTINAYNITITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRF 276

                 .
gi 205804177 366 R 366
Cdd:cd15174  277 R 277
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
64-369 5.21e-08

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 54.01  E-value: 5.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSD-LLAGAAYLANILLSGARTLRLSPAQWFLREGSMFVALSASVFSLLAIAIE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLLFKSTAR-RARGSILGIWAVSLAI-MVPQ------AAVMECSSVLPELANRTRLFSVcderwaddlypkiy 215
Cdd:cd15102   97 RHLTMAKMKPYGASKTsRVLLLIGACWLISLLLgGLPIlgwnclGALDACSTVLPLYSKHYVLFCV-------------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 hsCFFIVTYLAPLGLMAMAYFQIfrklwgrqipgttSALVRNWKRPSDqlgdleqglsgepQPRARAFLaevkqmrarrk 295
Cdd:cd15102  163 --TIFAGILAAIVALYARIYCLV-------------RASGRKATRASA-------------SPRSLALL----------- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 296 taKMLMVVLLVFALCYLPISVLnVLKRVFGmfrqasdreAVYACFTF--SHW---LVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15102  204 --KTVLIVLLVFIACWGPLFIL-LLLDVAC---------PVKTCPILykADWflaLAVLNSALNPIIYTLRSRELRRAV 270
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
77-362 5.31e-08

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 54.09  E-value: 5.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  77 MRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 156
Cdd:cd15156   31 VRNETTTYMINLAISDLLFV-FTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKT 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 --TARRARGSILGIWAVSLAIMVPqAAVMECSSVLPELANRTrlfsvCDERWADDLYpKIYHScfFIVTYLAPLGLMAMA 234
Cdd:cd15156  110 lrTKRNAKIVCAAVWLTVLAGSLP-ASFFQSTNNQLNNNSET-----CFENFSSKTW-KTYLS--KIVIFIEIVGFFIPL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 235 YFQIFrklwgrqipgTTSALVRNWKRPsdqlgdleqglsgepqprarafLAEVKQMRARRKTAKMLMVVLLVFALCYLPI 314
Cdd:cd15156  181 ILNVT----------CSTMVLKTLRRP----------------------NTLSRSKLNKKKVLKMIFVHLFIFCFCFIPY 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 205804177 315 SVLNVLKRVF--GMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362
Cdd:cd15156  229 NVNLVLYSLVrtQTFKNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTS 278
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
63-358 7.13e-08

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 53.54  E-value: 7.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15967   17 GNVWGLKSLLANWKKLGNINVFVLNLGLADLLYL-LTLPFLVVYYLKGRkWIFGQVFCKITRFCFNLNLYGSIGFLTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLlfkstarRARGSILGIWAVSLAIMVPQAAVMECssvLPELA------NRTRLFSVCDERWADDL--YPK 213
Cdd:cd15967   96 VYRYLAIVHPM-------RVMGRITTTHSVVISALVWLLVVIQS---LPDLFfsktnsNGTKCFDTTFNDYLESYltYSL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsalvrnwkrpsdqlGDLEQGLsgepqpraraflaevkqmraR 293
Cdd:cd15967  166 GWTVTGFVIPLLIILGCYGHVVVVLCRN------------------------NNVDKGL--------------------K 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 294 RKTAKMLMVVLLVFALCYLPISV---LNVLKRVF---GMFRQASDreAVYACFTFSHWLVYANSAANPIIY 358
Cdd:cd15967  202 QRCLKLVIILIVLFSVCYIPYHVfrnLNLLSRILqkqGSCTQWFR--GIYIAHQVSRGLVCLNSALNPLVY 270
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
64-368 8.17e-08

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 53.34  E-value: 8.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtaICLPASLLVDITES--WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15379   18 NAVVIGQIWATRQALSRTTIYMLNLATADLLY--VCSLPLLIYNYTQKdyWPFGDFTCRLVRFQFYTNLHGSILFLTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLL--FKSTARRARGSILG-IWAVSLAIMVPQAAVMECSSvlpeLANRTRLFSVCDERWADDLYPkiYHSC 218
Cdd:cd15379   96 VQRYLGICHPLAswHKKKGKKLTWLVCGaVWLVVIAQCLPTFVFASTGT----QRNRTVCYDLSPPARSTAYFP--YGIT 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmRARRKTAK 298
Cdd:cd15379  170 LTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPG----------------------------------EKRGKAAR 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 299 MLMVVLLVFALCYLPisvLNVLKRVFGMFRQASD-----REAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15379  216 MIIVVAAVFLISFLP---FHYTKTRYLQVRSWDGgpcttRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
63-367 1.07e-07

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 53.18  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLV------CLAVWRNhhmrtvTNYFIVNLSLADVLVtaIC-LPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVL 135
Cdd:cd15378   17 GNTIVilgyifCLKNWKS------SNIYLFNLSVSDLAF--LCtLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 136 TLSFIALDRWYAICHP-----LLFKSTARRARgsiLGIWAVSLAIMVPQAAVMEcssvlPELANRTrlfSVCDE--RWAD 208
Cdd:cd15378   89 FLTFISIDRYLLIKYPfrehiLQKKRSAVAIS---LAIWVLVTLELLPILTFIG-----PNLKDNV---TKCKDyaSSGD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 DLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGdleQGLSGEpqpraraflaevk 288
Cdd:cd15378  158 ATNSLIYSLFLTVTGFLIPLCVMCFFYYKIALFL----------------KNRNRQLA---NATSFE------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 qmrarrKTAKMLMVVLLVFALCYLPISVL-NVlkrvfgmfRQASDREA--VYAC--------FTFSHWLVYANSAANPII 357
Cdd:cd15378  206 ------KPLTLVILAVVIFSVLFTPYHVMrNV--------RIASRLDSigVSECtliiikslYIVTRPIAFLNSVINPVF 271
                        330
                 ....*....|
gi 205804177 358 YNFLSGKFRE 367
Cdd:cd15378  272 YFLMGDHFRE 281
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
87-369 1.16e-07

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 52.79  E-value: 1.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  87 NLSLADvlvtAICLPASLLVDITES----WLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHplLFKSTARRAR 162
Cdd:cd15922   41 NLALSD----AIITPAAPLLIAYFSlgshWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVH--YNWKSLWKKK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 163 GSI----LGIWAVSLAIMVPQAAVMECSsvlpELANRTRLFSVCDERWADdLYpKIYHSCFFIVTYLAPLGLMAMAYfqi 238
Cdd:cd15922  115 SFMkklcLGVWLLLFVQGLPFFFVLKTS----VIDGKTKCLSIHQSELSL-LY-FVWNFVLLILGFLLPFGVSLTCY--- 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 239 frKLWGRQIPGTTSALVRNWKrpsdqlgdleqglsgepqpraraflaevkqmrARRKTAKMLMVVLLVFALCYLPISVLN 318
Cdd:cd15922  186 --ALLGASIAKMNSNNARGRA--------------------------------MKAKSLQMIGISLVIFIICFVPLHVTR 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 205804177 319 VLKRVFGMFRQASDR--EAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15922  232 TVGVVVKLFYPESCTllHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
63-252 1.32e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 52.60  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITES---------WLFGhALCKVIPYLQAVSVSVA 133
Cdd:cd15136   17 GNIIVLLVLLTSRTKLTVPRFLMCNLAFAD-FCMGIYLGLLAIVDAKTLgeyynyaidWQTG-AGCKTAGFLAVFSSELS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 134 VLTLSFIALDRWYAICHP--LLFKSTARRARGSILGIWAVSLaIMvpqaavmecsSVLPELA-NRTRLFSVCDERWADDL 210
Cdd:cd15136   95 VFTLTVITLERWYAITHAmhLNKRLSLRQAAIIMLGGWIFAL-IM----------ALLPLVGvSSYSKTSICLPFETETP 163
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 205804177 211 YPKIYhSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTS 252
Cdd:cd15136  164 VSKAY-VIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSN 204
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
75-242 1.34e-07

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 52.49  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  75 HHMRTV-TNYFIVNLSLADVLVtAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPL 152
Cdd:cd15371   27 FRLRSVcTAIFYANLAISDLLF-CITLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPF 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 153 LFKSTARR--ARGSILGIWAVSLAIMVP-----------QAAVMECSSVLPELANRTRLFsvcderwaddlypkIYHSCF 219
Cdd:cd15371  106 IYRSLPKKtyAVLICALVWTIVFLYMLPffilkqtyylkELNITTCHDVLPECEQNSNFQ--------------FYYFIS 171
                        170       180
                 ....*....|....*....|....
gi 205804177 220 FIV-TYLAPLGLMAMAYFQIFRKL 242
Cdd:cd15371  172 MAVfGFLIPLVITIFCYISIIRTL 195
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
84-369 1.44e-07

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 52.46  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVTaICLPasLLVD---ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHP--LLFKSTA 158
Cdd:cd15200   38 YLLSLVVADFFLI-INLP--FRIDyylRNEVWRFGATACQVNLFMLSMNRTASIVFLTAIALNRYLKVVHPhhQLSKASV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 159 RRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWaddlypkiyHSCFFIVTYLAPLGLMAMAYFQI 238
Cdd:cd15200  115 GCAAKVAAGLWILILLLNIHLLLLDHVQSNSTCLSYDHGTDPSASDRW---------HRILFFLEFFLPLGIILFCIFSI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 239 FRKLWGRqipgttsalvrnwkrpsdqlgdleqGLSGEPQPraraflaevkqmrarRKTAKMLMVVLLVFALCYLPISVLN 318
Cdd:cd15200  186 ILTLKQR-------------------------KLAKQAGP---------------QRAVKVLAVIVLVYTVCFLPSILFA 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 205804177 319 VLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15200  226 LASLVAFKVSQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLNQS 276
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
64-366 1.63e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 52.60  E-value: 1.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15081   30 NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLTIISWE 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanrtRLFSVCD-ERWADDLYPKI--YHSCF 219
Cdd:cd15081  110 RWVVVCKPFgNIKFDGKLAIVGIIFSWVWSAVWCAP--PIFGWSRYWPH-----GLKTSCGpDVFSGSSDPGVqsYMIVL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQIFRKLwgRQIPGttsalvrnwkrpsdqlgdlEQGLSGEPQpraraflaevkqmRARRKTAKM 299
Cdd:cd15081  183 MITCCIIPLAIIILCYLQVWLAI--RAVAQ-------------------QQKESESTQ-------------KAEKEVSRM 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 300 LMVVLLVFALCYLPISvlnvlkrVFGMFRQASDReavYACFTFSHWL--VYANSAA--NPIIYNFLSGKFR 366
Cdd:cd15081  229 VVVMIFAYCFCWGPYT-------FFACFAAANPG---YAFHPLAAALpaYFAKSATiyNPIIYVFMNRQFR 289
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
78-367 1.85e-07

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 52.07  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADVLVTaICLPASLlVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS- 156
Cdd:cd15923   32 WTETNIYMTNLAVADLLLL-ISLPFKM-HSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRAREl 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 -TARRARGSILGIWAVSLAIMVPqaavmecSSVLPELANRTRLFSVCDERWADdlypkiyHSCFFIVT--YLAPLGLMAM 233
Cdd:cd15923  110 rSPRKAAVVCAVIWVLVVTISIP-------YFLLDSSNEKTMCFQRTKQTESL-------KVFLLLEIfgFLLPLIIMTF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 234 AYFQIFRKLWGRqipgttsalvrnwkrpsdqlgdleqglsgepqprarafLAEVKQMRARRKTAKMLMVVLLVFALCYLP 313
Cdd:cd15923  176 CSARVIHTLQKR--------------------------------------LDDVGSRSETKQCIRVIMANLIVFIVCFLP 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 205804177 314 ISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15923  218 VHVGFFVKFIVGKSYSCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFRE 271
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
63-366 2.56e-07

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 52.00  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15148   17 GNLLALWVFLFIHRKRNSVRIFLINVAIAD-LLLIICLPFRILYHVNNNqWTLGPLLCKVVGNLFYMNMYISIILLGFIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAIchpllFKSTARRA----RGSILG---IWAVSLAIMVPQAAVMECSSvlpelaNRTRLFSV---CDERWaddly 211
Cdd:cd15148   96 LDRYLKI-----NRSSRRQKfltrKWSIVAcgvLWAVALVGFVPMIVLTEKNE------ESTKCFQYkdrKNAKG----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 212 pKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsaLVRNWKRPsdqlgDLeqglsgepqPRARAFlaevkqmr 291
Cdd:cd15148  160 -KAIFNFLIVAMFWLVFLLLILSYGKIAKKL-----------LRISRDKP-----DF---------PNAAKY-------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 292 arRKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASD-----REAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15148  206 --NRTARKSFFVLFIFTVCFVPYHAF----RIFYITSQLQNnscywKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIR 279
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
65-364 2.63e-07

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 51.68  E-value: 2.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  65 TLVCLAvWRNHHMRTVTNYFIVNLSLADVLVtaICLPASLLVD--ITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd16001   20 TVLWLS-WCRTKRWTCSTIYLVNLAVADLLY--VCSLPLLIVNyaMRDRWPFGDFLCKLVRFLFYTNLYGSILFLTCISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPL--LFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSvlpeLANRTRLFSVCDERWADDLYPkiYHSCFF 220
Cdd:cd16001   97 HRFLGVCYPIrsLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGS----INNRTVCYDLTSPDNFGNYFP--YGMVLT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvrnwkrpsdqlgdlEQGLSGEPqpraraflaevkqmrARRKTAKML 300
Cdd:cd16001  171 VTGFLIPFLIILLCYCLMIKSLIRSE----------------------EAAGVGKA---------------ARAKSIRTI 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHW--LVYANSAANPIIYnFLSGK 364
Cdd:cd16001  214 LLVCGLFALCFVPFHITRTIYLFVRVYLVQDCPLLQFVSLAYKIWrpLVSFNSCINPLLY-FLSGD 278
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
63-366 2.70e-07

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 51.78  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPasLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSF 139
Cdd:cd15194   17 GNAILMGALVFKRGVRRLIDIFISNLAASD-FIFLVTLP--LWVDKEVVlgpWRSGSFLCKGSSYIISVNMYCSVFLLTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 140 IALDRWYAICHPLLFKSTARR--ARGSILGIWAVSlaimvpqaavmeCSSVLPELANRT-RLF---SVCDErwaDDLYP- 212
Cdd:cd15194   94 MSLDRYLAIVLPLVSRKFRTKhnAKVCCTCVWMLS------------CLLGLPTLLSRElKKYeekEYCNE---DAGTPs 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 213 -KIYHSCFFIVTYLAPLGLMAMAYFQIFRKlwgrqipgttsaLVRNWKRPSdqlgdleqglsgepqpraraflaevKQMR 291
Cdd:cd15194  159 kVIFSLVSLIVAFFLPLLSILTCYCTIIWK------------LCHHYQKSG-------------------------KHQK 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYA--CFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15194  202 KLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQVEVTCLPYTLAqlGMEVSAPLAFANSCANPFIYYFFDRYIR 278
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
63-362 3.59e-07

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 51.87  E-value: 3.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLL-VDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15217   17 GNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVsIRNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLFCIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPElaNRTRLFSVCDERWADDLYPKIYHSCF 219
Cdd:cd15217   97 VTRYMAIAHHRFYskRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIRE--EDQCIFEHRYFKANDTLGFMLMLAVL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLMAMAYFQifRKL------------WGRQIPGTTSALVRNW-------KRPSDQLGDLEQGLSgepqprA 280
Cdd:cd15217  175 IVATHIVYGKLLLFEYRH--RKMkpvqmvpaisqnWTFHGPGATGQAAANWiagfgrgPMPPTLLGIRQNAHT------A 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 281 RAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPIsVLNVLKRVFgmfrqasdreaVYACfTFSH-------WLVYANSAA 353
Cdd:cd15217  247 NRRLLGMEEFKAEKRLGRMFYVITLSFLVLWSPY-IVACYWRVF-----------VKAC-SIPHrylstavWMSFAQAGV 313

                 ....*....
gi 205804177 354 NPIIYNFLS 362
Cdd:cd15217  314 NPIVCFLLN 322
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
63-366 3.68e-07

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 51.28  E-value: 3.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLvtAIC-LPASLLVDITES-WLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15158   17 GNGFALYVLIKTYRQKSAFHIYMLNLAVSDLL--CVCtLPLRVVYYVHKGqWLFGDFLCRISSYALYVNLYCSIYFMTAM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPL--LFKSTARRARGSILGIWavsLAIMVPQAAVMECSSVLPElANRTRLFSVCDERWADDlYPKIYHSC 218
Cdd:cd15158   95 SFTRFLAIVFPVqnLNLVTVKKARIVCVGIW---IFVTLTSSPFLMSGSHDTE-TNKTKCFEPPQSNQQLT-KLLVLNYI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 219 FFIVTYLAPLGLMAMAYFQIFRKLWGRQipgttsalvrnwkrpsdqlgdleqglsgepqprarafLAEVKQMRARRKTAK 298
Cdd:cd15158  170 SLVVGFIIPFLVILICYAMIIRTLLKNT-------------------------------------MKARKQQSSRKKAIR 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 299 MLMVVLLVFALCYLPISV-----LNVLKRVfgmFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15158  213 MIIIVLLAFLVSFMPYHIqrtihLHFLSRK---DSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFR 282
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
64-369 3.76e-07

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 51.28  E-value: 3.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15086   18 NLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISLAVLSYE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLLFKSTA-RRARGSILGIWAVSLAIMVPqaAVMECSSVLPELANRTrlfsvCDERWADDLYPKI-YHSCFFI 221
Cdd:cd15086   98 RYCTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLP--PLLGWSSYGPEGPGTT-----CSVQWTSRSANSIsYIICLFI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 222 VTYLAPLGLMAMAYFQIFRKLwgRQIPGTTSALVRnwkrpsdqlgdleqglsgepqpraraflaevkqmraRRKTAKMLM 301
Cdd:cd15086  171 FCLLLPFLVMVYCYGRLLYAI--KQVGKINKSTAR------------------------------------KREQHVLLM 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 302 VVLLV--FALCYLPISVLNVLKrVFGMFRQASDREAVYACFtfshwLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15086  213 VVTMVicYLLCWLPYGVMALLA-TFGKPGLVTPVASIVPSI-----LAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
62-366 4.07e-07

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 51.34  E-value: 4.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtAICLPASLLVDITESWLFghaLCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15920   16 LSNTLALWVFFLRQQRETSISVYMRNLALADLLL-VLCLPFRVAYQNTAGPLS---FCKIVGAFFYLNMYASILFLSLIS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPL-LFK----STARRARGsilGIWAVSLAIMVPqaavmecssvlpeLANRTRLFSVCDERwaddlypkiyh 216
Cdd:cd15920   92 LDRYLKIIKPLqQFKihtvPWSSAASG---GVWLLLLACMIP-------------FLFESRNEGPCDNK----------- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 sCFFI---VTYLAPLGLMAMAYFQIFRKLWgrqipgttsalVRNWKRPSDQLGDLEQGLSGEPQPRAraflaevkQMRAR 293
Cdd:cd15920  145 -CFHFrskGLTAGGINLTAVVIFYILSLLF-----------LYFYAKISHKLYKVSLGNAQQQIKKA--------SKRAI 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 294 RKTakmlMVVLLVFALCYLP---ISVLNVLKRVfGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15920  205 IKT----FIVLAIFIVCFVPyhiVRVPYVLAQI-DVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
63-242 4.56e-07

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 50.92  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVtAICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15175   17 GNGLVILTYIYFKRLKTMTDIYLLNLALADILF-LLTLPF-WAASAAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHpllfKSTARRARG--------SILGIWAVSLAIMVPQAAVmecsSVLPELANRTRLFSVCDERwaDDLYPKI 214
Cdd:cd15175   95 DRYFAIVQ----AASAHRHRSravfiskvSSLGVWVLAFILSIPELLY----SGVNNNDGNGTCSIFTNNK--QTLSVKI 164
                        170       180
                 ....*....|....*....|....*...
gi 205804177 215 YHSCFFIvTYLAPLGLMAMAYFQIFRKL 242
Cdd:cd15175  165 QISQMVL-GFLVPLVVMSFCYSVIIKTL 191
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
64-369 5.16e-07

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 50.72  E-value: 5.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15328   18 NLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSgRRWQLGRSLCQVWISFDVLCCTASIWNVTAIAL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFK-STARRARGSILGI-WAVSLAImvpqaavmecsSVLPELANRTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15328   98 DRYWSITRHLEYTlRTRRRISNVMIALtWALSAVI-----------SLAPLLFGWGETYSEDSEECQVSQEPSYTVFSTF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLaPLGLMAMAYFQIFrklwgrqipgttsalvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKML 300
Cdd:cd15328  167 GAFYL-PLCVVLFVYWKIY------------------------------------------------KAAQKEKRAALMV 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 301 MVVLLVFALCYLPISVLNVLKRVFgmfrqASDREAVYACFTFshWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15328  198 GILIGVFVLCWIPFFLTELISPLC-----SCDIPPIWKSIFL--WLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
78-249 5.21e-07

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 50.80  E-value: 5.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADVLVTaICLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS- 156
Cdd:cd15165   32 WTESTIYMINLALNDLLLL-LSLPFKMHSSKKQ-WPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRl 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 -TARRARGSILGIWAVslaimvpqaaVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAY 235
Cdd:cd15165  110 rSPRKAAIVCLTIWVF----------VWAGSIPIYSFHDKPTNNTRCFHGFSNKTWSKKVIVVVEEFGFLIPMAVMVFCS 179
                        170
                 ....*....|....
gi 205804177 236 FQIFRKLWGRQIPG 249
Cdd:cd15165  180 VQIIRTLLDMRRPE 193
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
64-360 6.56e-07

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 50.56  E-value: 6.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAiCLPasLLVDI---TESWLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15366   18 NCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIA-TLP--LWIDYflhRDNWIHGPESCKLFGFIFYTNIYISIAFLCCI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPLLFkSTARRARGSIlgiwAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFF 220
Cdd:cd15366   95 SVDRYLAVAHPLRF-AKVRRVKTAV----AVSAVVWAIEIGANSAPLFHDELFRDRYNHTFCFEKYPMEDWVAWMNLYRV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 221 IVTYLAPLGLMAMAYFQIFRKLWGrqipgttsalvrnwkrpsdqlgdleqGLSGEPQPRARAflaevkqmrarRKTAKML 300
Cdd:cd15366  170 FVGFLFPWVLMLFSYRGILRAVRG--------------------------NVSTEQQEKAKI-----------KRLALSL 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 205804177 301 MVVLLvfaLCYLPISVLnVLKRVFGMFRQASD---REAVYACFTFSHWLVYANSAANPIIYNF 360
Cdd:cd15366  213 IAIVL---LCFAPYHVL-LLSRSVVYLGKPCDcgfEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
86-369 8.85e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 50.07  E-value: 8.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  86 VNLSLADVLVTaICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGS 164
Cdd:cd15375   40 LNLALTDLLYV-TSLPFLIYYYINgESWIFGEFMCKFIRFIFHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAI 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 165 I--LGIWAVSLAIMVPqaavMECSSVLPELANRTRLFSVCDERWADDLYPkiYHSCFFIVTYLAPLGLMAMAYFQIFRKL 242
Cdd:cd15375  119 VacAVVWVISLAEVSP----MTFLITTKEKNNRTICLDFTSSDNLNTIWW--YNWILTVLGFLLPLVIVTLCYTRIIYTL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 243 wgRQIPGTTSAlvrnwkrpsdqlgdleqglsgepqpraraflaevKQMRARRktakMLMVVLLVFALCYLPISVLNVLKR 322
Cdd:cd15375  193 --AKGPHTGSA----------------------------------SKQKARR----LIILILLVFYVCFLPFHILRVVRI 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 205804177 323 VFGMFR-QASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15375  233 ETRLPPvSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
64-369 1.32e-06

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 49.91  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNY-FIVNLSLADVLVTAICLPASLLVDI----TESWLFGHALCKVIpylqaVSVSVAVLTLS 138
Cdd:cd15340   18 NLLVLCVILHSRSLRCRPSYhFIGSLAVADLLGSVIFVYSFLDFHVfhrkDSPNVFLFKLGGVT-----ASFTASVGSLF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 139 FIALDRWYAICHPLLFKSTARRARGSIL--GIWAVSLAImvpqaavmecsSVLPELA-NRTRLFSVCDerwadDLYPKIY 215
Cdd:cd15340   93 LTAIDRYISIHRPLAYKRIVTRTKAVIAfcVMWTIAIVI-----------AVLPLLGwNCKKLNSVCS-----DIFPLID 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 HS--CFFIVTYLAPLGLMAMAYFQIfrkLWGRQipgttSALVRNWKRPSDQLGDLEQGLSGEPQprarafLAEVKQMRAR 293
Cdd:cd15340  157 ETylMFWIGVTSVLLLFIVYAYMYI---LWKAH-----HHAVRMLQRGTQKSIIVYTSEDGKVQ------TTRPDQTRMD 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 294 RKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDreAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15340  223 IRLAKTLVLILVVLIICWGPLLAI----MVYDVFGKMNK--LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
63-152 1.84e-06

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 49.11  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPaSLLVDIteswlfgHALCKVIPYLQAVSVSVAVLT------ 136
Cdd:cd15234   17 GNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVP-KMLVNI-------QTQSKSISYTGCLTQMCFFLLfggldn 88
                         90
                 ....*....|....*...
gi 205804177 137 --LSFIALDRWYAICHPL 152
Cdd:cd15234   89 flLAVMAYDRYVAICHPL 106
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
64-174 1.92e-06

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 49.02  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFG------HALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15351   18 NILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVcrapmlQHMDNVIDTMICSSVVSSLSFL 97
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 205804177 138 SFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLA 174
Cdd:cd15351   98 GAIAVDRYITIFYALRYHSimTLQRAVNAIAGIWLASTV 136
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
63-172 2.00e-06

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 49.14  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15235   18 GNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAY 97
                         90       100       110
                 ....*....|....*....|....*....|..
gi 205804177 143 DRWYAICHPLLFKSTARRAR--GSILGIWAVS 172
Cdd:cd15235   98 DRYVAICHPLHYATVMSPKRclLLVAGSWLLS 129
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
66-175 2.02e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.17  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  66 LVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 144
Cdd:cd14981   22 LIVLARSSKSHKWSVFYRLVAGLAITDLLGILLTSPVVLAVYAsNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVER 101
                         90       100       110
                 ....*....|....*....|....*....|...
gi 205804177 145 WYAICHPLLFKS--TARRARGSILGIWAVSLAI 175
Cdd:cd14981  102 FLAITHPFFYNShvKKRRARLMLGAVWAFALLI 134
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
84-362 2.44e-06

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 48.61  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVtaIC-LPASL-LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TAR 159
Cdd:cd15367   38 YLCNLTVADLLY--IFsLPFWLqYVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAfrTMK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 160 RARGSILGIWAVSLaimvpqaavMECSSVL--PELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQ 237
Cdd:cd15367  116 AATLVSTVIWLKEL---------MTCVFFFlhGEISKDKENHSVCFEHYPIKAWEHNINYYRFYAGFLFPIFLLSFSYCR 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 238 IFRKLwgRQIPGTtsalvrnwkrpsdqlgdleqglsgepqpraraflaevkQMRARRKTAKMLMVVLLVFALCYLPISVL 317
Cdd:cd15367  187 ILRAV--RKSHGT--------------------------------------QKSQKIQIKRLVLSTVVIFLVCFGPYHIL 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 205804177 318 NVLKRVFGmfRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362
Cdd:cd15367  227 LLVRSVFE--RDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFAS 269
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
62-178 2.46e-06

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 48.71  E-value: 2.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15183   16 VGNVLVVLVLIQHKRLRNMTSIYLFNLAISD-LVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLT 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 205804177 142 LDRWYAICHPLLfkstARRARGSILGI------WAVSLAIMVP 178
Cdd:cd15183   95 IDRYLAIVHAVF----ALRARTVTFGIitsiitWALAILASMP 133
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
78-369 2.97e-06

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 48.59  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADvLVTAICLPASLLVDITE-SWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS 156
Cdd:cd15119   31 KTVNTLWFLNLAIAD-FVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHR 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 157 TARRARGSILG--IWAVSLAIMVPQAAVMECSSVlpeLANRTRLFSvcDERWADDLYPKIYHSCF----FIVTYLAPLGL 230
Cdd:cd15119  110 YRTLKSALILCgiVWLSAAAISGPALYFRDTMEL---SINVTICFN--NFHKHDGDLIVMRHTILvwvrFFFGFLFPLLT 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 231 MAMAYfqifrklwgrqipgttSALVRNWKRpsdqlgdleqglsgepqpraraflaevKQMRARRKTAKMLMVVLLVFALC 310
Cdd:cd15119  185 MVVCY----------------SLLAIKVKR---------------------------RTLLISSKFFWTISAVIVAFFVC 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 311 YLPISVLNVLKRVfgMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15119  222 WTPYHIFSILELS--IHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
63-369 3.06e-06

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 48.87  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASL-LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15218   17 GNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFtSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLF--KSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTrlFSVCDERWADDLYPKIYHSCF 219
Cdd:cd15218   97 VTRYLAIAHHRFYtkRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCT--FQHRSFRANDSLGFMLLLALI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 220 FIVTYLAPLGLM----------AMAYFQIFRKLWGRQIPGTTSALVRNW-------KRPSDQLgdleqGLSGEPQPRARA 282
Cdd:cd15218  175 LLATQLVYLKLIffvhdrrkmkPVQFVAAVSQNWTFHGPGASGQAAANWlagfgrgPTPPTLL-----GIRQNANTTGRR 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 283 FLAEVKQMRARRKTAKMLMVVLLVFALCYLPIsVLNVLKRVFgmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLS 362
Cdd:cd15218  250 RLLVLDEFKMEKRISRMFYIMTFLFLTLWGPY-LVACYWRVF-----ARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSN 323

                 ....*..
gi 205804177 363 GKFREQF 369
Cdd:cd15218  324 RELRRCF 330
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
64-366 4.68e-06

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 47.91  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNY-FIVNLSLADVLVTAIClpASLLVDITeswLFGHALCKVIPYLQAVSVSV----AVLTLS 138
Cdd:cd15341   18 NVAVLYLILSSPKLRRKPSYlFIGSLALADFLASVVF--ACSFVDFH---VFHGVDSSAIFLLKLGGVTMsftaSLGSLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 139 FIALDRWYAICHPLLFKSTARRARGsilgiwAVSLAIMVPQAAVMecsSVLPELA-NRTRLFSVCDErwaddLYPKIYHS 217
Cdd:cd15341   93 LMAFDRYVCIYYPSEYKALVTRKRA------LVALAVMWVLTALI---AYLPLMGwNCCPLNSPCSE-----LFPLIPND 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 cffivtYLAPLGLMAMAYFQIFRKLWGRQIpgttsalvrnWKrPSDQLGDLEQGLSGEPQPRARaflaevkqMRARRKTA 297
Cdd:cd15341  159 ------YLLSWLLLVAILLSGIIYTYGHVL----------WK-AHKHVVYMEKHQDQQGPGNAR--------MRLDVRLA 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 298 KMLMVVLLVFALCYLPISVLNVLKRVFGMFRQasdreaVYACFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15341  214 KTLGLVLAVLLICWSPVLALMMHSLFTSLSDH------IKKAFAFCSTLCLVNSMVNPIIYALRSRELR 276
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
64-369 8.21e-06

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 47.14  E-value: 8.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNY-FIVNLSLADVLVTAICLPASLL------VDITESWLFghalcKVIPYLQAVSVSVAVLT 136
Cdd:cd15099   18 NILVLLTILSSTALRRRPSYlFIGSLALADMLASVIFTISFLDfhvfhqRDSRNLFLF-----KLGGVTMAFTASVGSLL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 137 LSfiALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAImvpqaavmecsSVLPELA-NRTRLFSVCDerwadDLYPK 213
Cdd:cd15099   93 LT--ALDRYLCIYQPSNYKLlvTRTRAKVAILLMWCVTIII-----------SFLPLMGwRCKTWDSPCS-----RLFPY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 I--YHSCFFIVTYLAPLGLMAMAYFQIFrklwgrqipgttsalvrnWKRPSDQLGDLEQGLSGEPQPRaraflaeVKQMR 291
Cdd:cd15099  155 IdrHYLASWTGLQLVLLFLIIYAYPYIL------------------WKAHRHEANMGGPKLGRQQVKG-------QARMR 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 292 ARRKTAKMLMVVLLVFALCYLPISVLnvlkRVFGMFRQASDReaVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15099  210 MDIRLAKTLSLILLVLAICWLPVLAF----MLVDVRVTLTNK--QKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
63-183 9.87e-06

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 46.71  E-value: 9.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPaSLLVDIteswLFGHalcKVIPY----LQAVSV----SVAV 134
Cdd:cd15912   17 GNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIP-KMLANL----LSGK---KTISFagcfAQSFFYfflgTTEF 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 205804177 135 LTLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVM 183
Cdd:cd15912   89 FLLAVMSFDRYVAICNPLHYPTimNSRVCLQLVLGSWVGGFLLILPPTILV 139
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
78-178 1.10e-05

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 46.74  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKS- 156
Cdd:cd15166   32 RTTVTVYMMNVALVD-LIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQPKHAKEl 110
                         90       100
                 ....*....|....*....|...
gi 205804177 157 -TARRARGSILGIWAVSLAIMVP 178
Cdd:cd15166  111 kNTPKAVLACVGVWIMTLASTFP 133
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
64-369 1.43e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 46.33  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWL------FGHALCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15103   18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYlvprdsFEQHIDNVIDSMICSSLLASICSL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSSVLpelanrtrlfsVCderwaddlypkiy 215
Cdd:cd15103   98 LAIAVDRYITIFYALRYHSimTVRRAGVIITAIWVFCTVCGILFIIYSDSVPVI-----------IC------------- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 216 hscfFIVTYLAPLGLMAMAYFQIFrkLWGRQIPGTTSALvrnwkrpsdqlgdleqglsgepqPRARAflaevKQMRARRK 295
Cdd:cd15103  154 ----LISMFFAMLVLMASLYVHMF--LLARSHVKKIAAL-----------------------PGQRS-----TRQRANMK 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 205804177 296 TAKMLMVVLLVFALCYLPIsVLNVLKRVFgmfrqaSDREAVYACFtFSHW-----LVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15103  200 GAVTLTILLGVFIFCWAPF-FLHLTLMIS------CPSNPYCACY-MSHFnvyliLIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
65-157 1.47e-05

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 46.26  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  65 TLVCLavwrNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 144
Cdd:cd15405   23 TLICL----NSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDR 98
                         90
                 ....*....|...
gi 205804177 145 WYAICHPLLFKST 157
Cdd:cd15405   99 YVAICNPLLYTVT 111
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
64-367 1.54e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 46.31  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaicLPASLLVDITES---WLFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15075   18 NATVIIVTLRHKQLRQPLNYALVNLAVADLGTT---VFGGLLSVVTNAvgyFNLGRVGCVLEGFAVAFFGIAALCTVAVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 141 ALDRWYAICHPL-LFKSTARRARGSILGIWAVSLAIMVPQ---------AAVMecSSVLPELANRtrlfsvcderwadDL 210
Cdd:cd15075   95 AVDRLFVVCKPLgTLTFQTRHALAGIASSWLWSLIWNTPPlfgwgsyqlEGVM--TSCAPDWYSR-------------DP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 211 YPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWgrqipgttsalvrnwkrpsdQLGDLEQGLSGEPQpraraflaevkqm 290
Cdd:cd15075  160 VNVSYILCYFSFCFAIPFAIILVSYGYLLWTLR--------------------QVAKLGVAEGGSTA------------- 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 205804177 291 RARRKTAKMLMVVLLVFALCYLPISVLNVLkrVFGmfrqASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15075  207 KAEVQVARMVVVMVMAFLLCWLPYAAFALT--VVS----KPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
63-160 1.84e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 46.24  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLP---ASLLVDiteswlfghalCKVIPYLQAVS---VSVAVLT 136
Cdd:cd15429   17 GNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPqmlAHFLAE-----------HKTISFASCVAqlfISLALGG 85
                         90       100
                 ....*....|....*....|....*....
gi 205804177 137 LSFI-----ALDRWYAICHPLLFKSTARR 160
Cdd:cd15429   86 TEFIllavmAYDRYVAVCHPLRYTVIMSG 114
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
68-369 2.22e-05

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 45.93  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  68 CLAVWRNHHM---RTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDR 144
Cdd:cd15364   19 CLTLWLTLLQvrrKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCNIYISILLLCCISIDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 145 WYAICHPLLFKSTaRRARGSILGIWAVSLAIMVPQAAVMECSSvlPELANRTRLFSVCDerwADDLYPKIYHScFFIVTY 224
Cdd:cd15364   99 FVAVVYALESRGR-RRQRIAAFISFLIFIVVGLVHSPVFIMRE--GQTEGSHTCFETLQ---MDTQVAGFYYA-RFCIGF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 225 LAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkRPSDQLgdleqglsgepQPRARAflaevkqmrarrKTAKMLMVVL 304
Cdd:cd15364  172 AIPLAILIFTNYRIFRSI-----------------QTSTSL-----------TPHQKA------------KVKYLAIAVI 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 205804177 305 LVFALCYLPISVLNVLKRV-FGMFRQASD--REAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15364  212 VIFLICFAPYHLVLLVRAIaFSLYPNGMCgfEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
63-172 3.03e-05

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 45.30  E-value: 3.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPaSLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15918   17 GNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVP-KMLVNIqTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMA 95
                         90       100       110
                 ....*....|....*....|....*....|...
gi 205804177 142 LDRWYAICHPLLFKSTARRARGSIL--GIWAVS 172
Cdd:cd15918   96 YDRYVAICHPLHYTTIMSPRLCILLvaASWVIT 128
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
62-242 3.32e-05

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 45.20  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15185   16 LGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFL-FTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHPLLfkstARRARGSILGI------WAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWaddlypKIY 215
Cdd:cd15185   95 IDRYLAIVHAVF----ALRARTVTFGIitsiitWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDSW------KRF 164
                        170       180
                 ....*....|....*....|....*...
gi 205804177 216 HSCFFIVTYLA-PLGLMAMAYFQIFRKL 242
Cdd:cd15185  165 HALRMNIFGLAlPLLIMVICYTGIIKTL 192
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
84-368 3.33e-05

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 45.17  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPllFKSTARRARG 163
Cdd:cd15153   38 FMINLAVAD-LAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCISIQRCFFLLHP--FKARDWKRRY 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 164 SIlgiwAVSLAIMVpqaAVMECSSVLPELANRTRLFSVcderwaddlypkiyHSCFFIVTYLAPLGLMAMAYFQIfRKLW 243
Cdd:cd15153  115 DV----GISAAVWI---VVGLACLPFPLLRSKSLSNNN--------------RSCFADLGMKKLNFGAAIAMMTV-AELF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 244 GRQIPGTTSALVrNWKrpsdqlgdLEQGLSGEPQpraraflaEVKQMRARRKTAKMLMVVLLVFALCYLPISVlNVLKRV 323
Cdd:cd15153  173 GFVIPLFIIAWC-TWK--------TENSLRQRNK--------QQQSTSEKQKALRMVRMCAAVFFICFAPYHI-NFLFYL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 205804177 324 FGMFRQASDREAVYACFTF---SHWLVYANSAANPIIYNFLSGKFREQ 368
Cdd:cd15153  235 MVSESIITNCEVSQVILQFhpiSLCLASLNCCLDPILYYFMTSEFQDQ 282
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
63-178 3.53e-05

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 45.17  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESwlfghalcKVIPYLQAVS-----VSVAV--- 134
Cdd:cd13954   17 GNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGD--------KTISFSGCLTqlyffFSLGGtec 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 205804177 135 LTLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVS-LAIMVP 178
Cdd:cd13954   89 FLLAVMAYDRYVAICHPLHYPTimNKRVCILLAAGSWLIGfLNSLIH 135
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
84-362 3.77e-05

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 45.16  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVTAIcLPasLLVDIT---ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFkSTARR 160
Cdd:cd15365   38 YLFNLSLSDLLYIVI-LP--LWIDYLwngDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKF-MHLRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 161 ARGSILgiwaVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFr 240
Cdd:cd15365  114 IRTALS----VSVAIWLLEICFNAVILTWEDSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLIILFCYWKIY- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 241 klwgrqipgttsALVRNWKRPSDQlgdleqglsgepqpraraflaevkqmrARRKTAKMLMVVLLVFALCYLPISVLNVL 320
Cdd:cd15365  189 ------------QAVRSNQATEDQ---------------------------EKKKIFKLLLLITVTFVICFTPYHVVLLI 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 205804177 321 KRVF--GMFRQASDreaVYACFTFSHWLVYANSAANPIIYNFLS 362
Cdd:cd15365  230 RSIVepCDCRNAKW---LYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
63-368 4.16e-05

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 45.20  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPAslLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd14989   17 GNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIE--VFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTWMSF 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAI-----CHPLlfkSTARRARGSILGIWAVS-LAIMVPqaavmecssvlpelanrtrlFSVCDERWADDLypkiyH 216
Cdd:cd14989   95 DRYIALakvmkSSPL---RTMQHARLSCGLIWMASiSATLLP--------------------FTAVQAQHTGEV-----H 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 217 SCFFIVT----------YLAPLGLMAMAYFQIFRklwgrqipgttsALVRNWKRpsdqlgdleqglsgepqpraraflae 286
Cdd:cd14989  147 FCFADVReiqwlevtlgFIIPFSIIGLCYSLIVR------------VLVRAQKH-------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 vKQMRARRKTA-KMLMVVLLVFALCYLPisvLNVLKRVFGMFRQASDREAVYACFTFSHWLV--------YANSAANPII 357
Cdd:cd14989  189 -RRLRPRRQKAlRMILVVVLVFFICWLP---ENVFISIQLLQGTQEPSESYDESFRHNHPLTghivnlaaFSNSCLNPLI 264
                        330
                 ....*....|.
gi 205804177 358 YNFLSGKFREQ 368
Cdd:cd14989  265 YSFLGETFRDK 275
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
63-190 4.29e-05

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 44.85  E-value: 4.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHAL-------CKVIPYLQAVSVSVAVL 135
Cdd:cd15359   17 GNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKSQYYNHAIdwqtgsgCSTAGFFTVFASELSVY 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 205804177 136 TLSFIALDRWYAICHPLLF--KSTARRARGSILGIWAVSLAI-MVPQAAV---MECSSVLP 190
Cdd:cd15359   97 TLTVITLERWHTITYAMQLdrKLRLRHAILIMLGGWVFSLLIaVLPLVGVsnyMKVSICLP 157
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
63-161 5.07e-05

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 44.77  E-value: 5.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15418   18 GNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAY 97
                         90
                 ....*....|....*....
gi 205804177 143 DRWYAICHPLLFKSTARRA 161
Cdd:cd15418   98 DRYVAICNPLLYSSAMSKK 116
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
63-154 7.96e-05

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 44.32  E-value: 7.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15409   17 GNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAY 96
                         90
                 ....*....|..
gi 205804177 143 DRWYAICHPLLF 154
Cdd:cd15409   97 DRYVAICNPLLY 108
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
63-169 8.05e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 44.13  E-value: 8.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADvlvtaICLPASLL----VDI-TESWLFGHAL-------CKVIPYLQAVSV 130
Cdd:cd15964   17 GNVFVLLILLTSHYKLTVPRFLMCNLAFAD-----FCMGIYLLliasVDLhTRSEYYNHAIdwqtgpgCNTAGFFTVFAS 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 205804177 131 SVAVLTLSFIALDRWYAICHPLLF--KSTARRARGSILGIW 169
Cdd:cd15964   92 ELSVYTLTVITLERWYAITFAMRLdrKIRLRHASAIMLGGW 132
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
63-157 8.72e-05

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 44.28  E-value: 8.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15406   26 GNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAY 105
                         90
                 ....*....|....*
gi 205804177 143 DRWYAICHPLLFKST 157
Cdd:cd15406  106 DRYVAICNPLLYNVT 120
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
62-152 9.27e-05

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 44.01  E-value: 9.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLP---ASLL-VDITESwlFGHalCKVIPYLQAVSVSVAVLTL 137
Cdd:cd15911   16 AGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPrmlASLLtGDRTIS--VSG--CIVQFYFFGSLAATECYLL 91
                         90
                 ....*....|....*
gi 205804177 138 SFIALDRWYAICHPL 152
Cdd:cd15911   92 AVMSYDRYLAICKPL 106
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
63-185 9.39e-05

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 43.94  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15950   17 GNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAF 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAV--SLAIMVPQAAVMEC 185
Cdd:cd15950   97 DRYVAICHPLRYSAILTSQVIAQIGLAIVlrALLFMTPLTCLVTS 141
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
62-152 9.60e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 43.75  E-value: 9.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15431   16 LGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMA 95
                         90
                 ....*....|.
gi 205804177 142 LDRWYAICHPL 152
Cdd:cd15431   96 YDRFVAICNPL 106
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
77-366 1.03e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 43.67  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  77 MRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLL-FK 155
Cdd:cd15080   31 LRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSnFR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 156 STARRARGSILGIWAVSLAIMVPqaAVMECSSVLPElanrtRLFSVCDERWAdDLYPKIYHSCF----FIVTYLAPLGLM 231
Cdd:cd15080  111 FGENHAIMGVAFTWVMALACAAP--PLVGWSRYIPE-----GMQCSCGIDYY-TLKPEVNNESFviymFVVHFTIPLIVI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 232 AMAYfqifrklwGRQIPGTTSALVRNWKRPSDQlgdleqglsgepqpraraflaevkqmRARRKTAKMLMVVLLVFALCY 311
Cdd:cd15080  183 FFCY--------GRLVCTVKEAAAQQQESATTQ--------------------------KAEKEVTRMVIIMVIAFLICW 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 312 LPISvlNVLKRVFgmFRQASDREAVYacFTFSHWLVYANSAANPIIYNFLSGKFR 366
Cdd:cd15080  229 VPYA--SVAFYIF--THQGSDFGPIF--MTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
63-160 1.13e-04

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 43.79  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15231   17 GNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAY 96
                         90
                 ....*....|....*...
gi 205804177 143 DRWYAICHPLLFKSTARR 160
Cdd:cd15231   97 DRYVAICNPLHYAVIMSR 114
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
63-369 1.29e-04

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 43.55  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVL-VTAICLPASLLVdITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15157   17 GNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMfVSTLPFRADYYL-MGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVLS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 142 LDRWYAICHP--LLFKSTARRARGSILGIWAVslaimvpqaaVMECSSVLpeLANRTRLFSvcDERWADDLYP------K 213
Cdd:cd15157   96 IVRFLAIVHPfkLWKVTSIKYARILCAVIWIF----------VMAASSPL--LSKGTSKYN--SQTKCLDLHPskidklL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 IYHSCFFIVTYLAPLGLMAMAYFQIFRklwgrqipgttsALVRnwkrpsdqlgdleqglSGEPQPRARAflaevkqmrAR 293
Cdd:cd15157  162 ILNYIVLVVGFILPFCTLSICYILIIK------------ALLK----------------PRVPQSKLRV---------SH 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 294 RKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFShwLVYANSAANPIIYNFLSGKFREQF 369
Cdd:cd15157  205 KKALLTIIITLILFLLCFLPYHILRTVHLMQWSEGQCNLRLHKAVVITLC--LAAANSCLDPLLYYFAGENFKERL 278
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
69-367 1.44e-04

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 43.21  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  69 LAVWRNHHMRTVTNY--FIVNLSLADvLVTAICLPASLLVDIT-ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRW 145
Cdd:cd15924   20 LAMWIFFHIPSKSSFiiYLKNTVVAD-LLMILTFPFKILSDAGlGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRY 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 146 YAICHPLLFKSTARRARGSILGI--WAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLypkiyhSCFFIVT 223
Cdd:cd15924   99 LKIVRPFKTSFPKSVSFAKILSVvvWALMFLLSLPNMILTNQQPREKNVKKCSFLKSELGLKWHEIV------NYICQVI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 224 YLAPLGLMAMAYFQIFRKLWgrqipgttsalvRNWKRPSdqlgdleqglsgepqpraraflaeVKQMRARRKTAKMLMVV 303
Cdd:cd15924  173 FWIVFLLMIVCYTAITKKVY------------RSYRRVF------------------------RSSSSRRKKSNVKIFII 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 304 LLVFALCYLPISVLnvlkRVFGMFRQASDREAVYACFT------FSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15924  217 VAVFFVCFVPYHFA----RIPYTLSQTRDVFDCTAENIlfyvkeATLFLSALNVCLDPIIYFFLCKSFRE 282
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
63-190 1.76e-04

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 43.13  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIpYLQAVSVSVAVLtLSFI 140
Cdd:cd15914   17 GNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLsnLLSEEKTISFNGCLLQMY-FFHSLGITECYL-LTAM 94
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 205804177 141 ALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMecsSVLP 190
Cdd:cd15914   95 AYDRYLAICNPLHYPSimTPKLCTQLAAGCWLCGFLGPVPEIILI---STLP 143
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
63-185 1.76e-04

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 43.19  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15424   17 GNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAY 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGI--WAVSLAIMVPQAAVMEC 185
Cdd:cd15424   97 DRYLAICHPLLYAAAMGRWRQLQLALscWAIGFLLSVINVGCTLR 141
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
63-154 2.32e-04

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 42.79  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15415   17 GNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAY 96
                         90
                 ....*....|..
gi 205804177 143 DRWYAICHPLLF 154
Cdd:cd15415   97 DRYVAICNPLLY 108
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
64-369 2.81e-04

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 42.56  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADvLVTAICLPASLLvditeswLFGHALCKVIP---YLQA----VSVSVAVLT 136
Cdd:cd15346   18 NIFVLLTIWKTKKFHRPMYYFIGNLALSD-LLAGVAYTANLL-------LSGATTYKLTPtqwFLREgsmfVALSASVFS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 137 LSFIALDRWYAICHPLLFK-STARRARGSILGIWAVS-----LAIMVPQ--AAVMECSSVLPelanrtrlfsvcderwad 208
Cdd:cd15346   90 LLAIAIERYITMLKMKLHNgSNSFRSFLLISACWVISlilggLPIMGWNciSALSSCSTVLP------------------ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 dLYPKiyHSCFFIVTYLAPLgLMAMA--YFQIFRKLWGRQIPGTtsaLVRNWKRPSdqlgdleqglsgEPQPRARAFLae 286
Cdd:cd15346  152 -LYHK--HYILFCTTVFTLL-LLSIVilYCRIYSLVRTRSRRLT---FRKNIRKAS------------RSSEKSMALL-- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 287 vkqmrarrktaKMLMVVLLVFALCYLPISVLNVLKrvFGMFRQASDreavyACFTFSHWLVYA--NSAANPIIYNFLSGK 364
Cdd:cd15346  211 -----------KTVIIVLSVFIACWAPLFILLLLD--VGCKVKTCS-----ILFKAEYFLVLAvlNSATNPIIYTLTNKE 272

                 ....*
gi 205804177 365 FREQF 369
Cdd:cd15346  273 MRRAF 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
63-152 3.99e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 42.04  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15940   17 GNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAY 96
                         90
                 ....*....|
gi 205804177 143 DRWYAICHPL 152
Cdd:cd15940   97 DRYVAICNPL 106
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
64-154 4.12e-04

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 41.88  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15224   18 NLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYD 97
                         90
                 ....*....|.
gi 205804177 144 RWYAICHPLLF 154
Cdd:cd15224   98 RYVAICHPLRY 108
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
62-178 4.32e-04

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 42.05  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDITEsWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15184   16 VGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFL-LTLPFWAHYAANE-WVFGNAMCKLLTGLYHIGFFSGIFFIILLT 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 205804177 142 LDRWYAICHPLLfkstARRARGSILGI------WAVSLAIMVP 178
Cdd:cd15184   94 IDRYLAIVHAVF----ALKARTVTFGVvtsvvtWVVAVFASLP 132
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
68-182 5.66e-04

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 41.67  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  68 CLAVW---RNHHMRTVTNYFIVNLSLADVLVTaICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15167   19 CFALWafiQKRSSRKCINIYLINLLTADFLLT-LALPVKIAVDLgIAPWKLKIFHCQVTACLIYINMYLSIIFLGFVSID 97
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 205804177 144 RWYAICHPLLFKSTARRARGSILG--IWAVSLAIMVPQAAV 182
Cdd:cd15167   98 RYLQLTHSSKLYRIQEPGFAKMISavVWTLVLFIMVPNMAI 138
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
84-174 6.23e-04

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 41.25  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADvLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR--A 161
Cdd:cd15152   38 FMINLAIAD-LLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNDCKRKcdV 116
                         90
                 ....*....|...
gi 205804177 162 RGSILGIWAVSLA 174
Cdd:cd15152  117 YISIAGWLVVCVG 129
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
78-254 6.32e-04

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 41.31  E-value: 6.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  78 RTVTNYFIVNLSLADVLVTaICLPAsLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKST 157
Cdd:cd15188   33 KKMTEVYLLNLAVSDLLFL-VTLPF-WAMYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 158 ARRARGSILG--IWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWadDLYPKIYHScffIVTYLAPLGLMAMAY 235
Cdd:cd15188  111 RTRRKSLLVLvaVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHTIW--KLVFQFQQN---LLGFLFPLLAMVFFY 185
                        170
                 ....*....|....*....
gi 205804177 236 FQIFRKLWGRQIPGTTSAL 254
Cdd:cd15188  186 SRIACVLTRLRPPGQGRAL 204
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
64-366 7.69e-04

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 40.92  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVL-----VTAICLPASLLVDIT-ESWLFGHALCkvipylqAVSVSVAVLTL 137
Cdd:cd15349   18 NLLVLLAILRRVRLRRWVYICLANIALSDLLtgtsyLVNICLSGERTFRLTpALWFLREGLL-------FTALAASTFSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 138 SFIALDRWYAICHPLLFKSTAR--RARGSILGIWAVSLAI-MVP------QAAVMECSSVLPELANRTRLFSVCderwad 208
Cdd:cd15349   91 LVTAVERYATMVRPVAENTATKtyRVYGMIVLCWILAFLIgFLPllgwncLCDFRSCSSLLPLYSKSYILFCLV------ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 209 dlypkiyhsCFFIVTylapLGLMAmAYFQIFRklwgrqipgttsaLVRNwkrpsdqlgdleqglSGEPQPRARAflaevk 288
Cdd:cd15349  165 ---------IFFIIL----LTIIG-LYFAIYC-------------LVRA---------------SGQRVISARS------ 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 289 qMRARRKTAKMLMVVLLVFALCYLPISVLnVLKRVFGMFRQAS---DREAVYAcftfshwLVYANSAANPIIYNFLSGKF 365
Cdd:cd15349  197 -RRRSLRLLKTVLMILGAFMVCWGPLFIL-LLVDFFCSSRSCKplfGMEWVLA-------LAVLNSAINPLIYSFRSLEV 267

                 .
gi 205804177 366 R 366
Cdd:cd15349  268 R 268
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
62-152 7.98e-04

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 40.90  E-value: 7.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  62 VGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALC--KVIPYLQAVSVSVAVLTLsf 139
Cdd:cd15227   16 TGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCvaQVFLFIFFAASELALLTV-- 93
                         90
                 ....*....|...
gi 205804177 140 IALDRWYAICHPL 152
Cdd:cd15227   94 MAYDRYVAICHPL 106
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
84-367 8.61e-04

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 40.99  E-value: 8.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  84 FIVNLSLADVLVTaICLPASLLVDI-TESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRAR 162
Cdd:cd15149   37 YLKNIVFADLLMS-LTFPFKILSDVeLGPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGY 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 163 GSILG--IWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWaDDLYPKIYHSCFFIVTYlaplgLMAMAYFQIFR 240
Cdd:cd15149  116 SKALSvvVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSELGIQW-HKASNYICVSIFWVVFL-----LLIIFYVAISR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 241 KLWGRQipgttsalvRNWKRPSDQLgdleqglsgepqpraraflaevkqmraRRKTAKMLMVVLLVFALCYLPISVLNV- 319
Cdd:cd15149  190 KIYKSN---------QKFRRNSTNM---------------------------KAKSSRNIFSILFVFFVCFVPYHALRIp 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 205804177 320 -LKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15149  234 yTLSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFRE 282
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
63-154 1.02e-03

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 40.57  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15230   17 GNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAY 96
                         90
                 ....*....|..
gi 205804177 143 DRWYAICHPLLF 154
Cdd:cd15230   97 DRYVAICNPLLY 108
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
63-152 1.05e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 40.82  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15430   17 GNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAY 96
                         90
                 ....*....|
gi 205804177 143 DRWYAICHPL 152
Cdd:cd15430   97 DRYVAICNPL 106
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
63-174 1.06e-03

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 40.52  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPaSLLVDIteswlfgHALCKVIPYLQAVS--------VSVAV 134
Cdd:cd15236   17 GNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVP-KMLMNM-------QTQDQSIPYAGCISqmyffiffGCLDS 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 205804177 135 LTLSFIALDRWYAICHPLLFKSTARRARGSIL--GIWAVSLA 174
Cdd:cd15236   89 FLLAVMAYDRYVAICHPLHYTAIMRPELCVLLvaGSWVLTCF 130
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
63-176 1.17e-03

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 40.72  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15410   30 GNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAY 109
                         90       100       110
                 ....*....|....*....|....*....|....
gi 205804177 143 DRWYAICHPLLFKSTARRARGSILGIWAVSLAIM 176
Cdd:cd15410  110 DRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIV 143
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
63-173 1.17e-03

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 40.66  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15229   17 GNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAY 96
                         90       100       110
                 ....*....|....*....|....*....|...
gi 205804177 143 DRWYAICHPLLFKST--ARRARGSILGIWAVSL 173
Cdd:cd15229   97 DRYAAICHPLHYVQImsKQVCVQLVGGAWALGF 129
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
63-166 1.19e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 40.63  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15938   17 GNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAY 96
                         90       100
                 ....*....|....*....|....
gi 205804177 143 DRWYAICHPLLFKSTARRARGSIL 166
Cdd:cd15938   97 DRYVAICKPLHYTTIMSRRLCWVL 120
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
79-367 1.27e-03

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 40.32  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  79 TVTNYFIVNLSLADVLVtaIC-LPASLLVDITESWlfGHALCKVIP--YLQAVSVSVAVLTLsfIALDRWYAICHPLLFK 155
Cdd:cd15164   33 TETRVYMINLAVADCCL--LFsLPFVLYFLKHSWP--DDELCLVLQsiYFINRYMSIYIITA--IAVDRYIAIKYPLKAK 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 156 S--TARRARGSILGIWAVSLAIMVPQAAVMECSSvlpelanrtrlfSVCDERwaDDLYPKIYHSCFFIVTYLAPLGLMAM 233
Cdd:cd15164  107 SlrSPRKAALTCGLLWVLVIISVSLRLAWEEQEE------------NFCFGK--TSTRPSKRTLIFSLLGFFIPLIILSF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 234 AYFQIFRKlwgrqipgttsaLVRNWKRPSdqlgdleqglsgepqpraraflAEVKQMrarRKTAKMLMVVLLVFALCYLP 313
Cdd:cd15164  173 CSIQVIRS------------LKKKKKTNP----------------------HEEKLI---QKAIYIVSANLIVFIVCFLP 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 314 ISVLNVLKRVFGMFRQA-SDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFRE 367
Cdd:cd15164  216 LHIGLLVRFVMESNKAScSLIQNIRNFIYVASCLANANCCLDAICYYFVAKEFQE 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
63-152 1.42e-03

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 40.34  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIPYLqAVSVSVAVLtLSFI 140
Cdd:cd15237   17 GNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLvhLLSEHKTISFVGCAAQMFFFL-ALGVTECVL-LAVM 94
                         90
                 ....*....|..
gi 205804177 141 ALDRWYAICHPL 152
Cdd:cd15237   95 AYDRYVAICNPL 106
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
63-154 1.50e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 40.11  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPaSLLVDITeswlfghALCKVIPY----LQ----AVSVSVAV 134
Cdd:cd15945   30 GNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGP-KMLVDLL-------AKRKSIPFygcaLQmfffAAFADAEC 101
                         90       100
                 ....*....|....*....|
gi 205804177 135 LTLSFIALDRWYAICHPLLF 154
Cdd:cd15945  102 LLLAVMAYDRYVAICNPLLY 121
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
63-154 1.88e-03

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 40.04  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15943   31 GNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAY 110
                         90
                 ....*....|..
gi 205804177 143 DRWYAICHPLLF 154
Cdd:cd15943  111 DRYVAICNPLLY 122
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
64-369 2.08e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 39.62  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTaiclpASLLVDITESWLFGHALCKVIPY-LQAVSVSVAVLTLSFIAL 142
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAG-----IGLILNFIFAYLLQSEAAKLVTVgLIVASFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 143 DRWYAICHPLLFKS--TARRARGSILGIWAVSLAI-MVPQAAV------MECSSVLPELANRTRLFSvcderwaddlypk 213
Cdd:cd15961   93 DRYLSLYYALTYNSerTVTFTYVMLVLLWGASICLgLLPVMGWncladeSTCSVVRPLTKNNAAILS------------- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 214 iyhscffiVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwKRPSDQLGdleqglsgepqpRARAFLAeVKQMRAR 293
Cdd:cd15961  160 --------VSFLLMFALMLQLYIQICKIV----------------MRHAHQIA------------LQHHFLA-TSHYVTT 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 294 RKTAKMLMVVLLVFALCYLPISVLNVLkrvfgmfrqasdreavyACFTFSHWLVYA-------NSAANPIIYNFLSGKFR 366
Cdd:cd15961  203 RKGVSTLAIILGTFAACWMPFTLYSLI-----------------ADYTYPSIYTYAtllpatyNSIINPVIYAFRNQEIQ 265

                 ...
gi 205804177 367 EQF 369
Cdd:cd15961  266 KAL 268
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
63-155 2.16e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 39.77  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLqAVSVSVAVLTL-SFIA 141
Cdd:cd15946   17 GNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYI-FLALGITECTLfSVMA 95
                         90
                 ....*....|....
gi 205804177 142 LDRWYAICHPLLFK 155
Cdd:cd15946   96 YDRYVAICHPLRYK 109
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
64-366 2.24e-03

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 39.81  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15077   18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSLAVVAFE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICHPLlfKSTARRARGSILG---IWAVSLAIMVPqaAVMECSSVLPElanrtRLFSVCDERW---ADDLYPKIYHS 217
Cdd:cd15077   98 RFLVICKPL--GNFTFRGTHAIIGciaTWVFGLAASLP--PLFGWSRYIPE-----GLQCSCGPDWyttNNKWNNESYVM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 218 CFFIVTYLAPLGLMAMAYFQIFRKLwgrqipgttsalvrnwkrpsdQLGDLEQGLSGEPQpraraflaevkqmRARRKTA 297
Cdd:cd15077  169 FLFCFCFGVPLSIIVFSYGRLLLTL---------------------RAVAKQQEQSASTQ-------------KAEREVT 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 298 KMLMVVLLVFALCYLPISVLnVLKRVFGMFRQASDREA-VYACFTfshwlvYANSAANPIIYNFLSGKFR 366
Cdd:cd15077  215 KMVVVMVLGFLVCWLPYASF-ALWVVTNRGEPFDLRLAsIPSVFS------KASTVYNPVIYVFMNKQFR 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
63-155 2.45e-03

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 39.61  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15408   30 GNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAY 109
                         90
                 ....*....|...
gi 205804177 143 DRWYAICHPLLFK 155
Cdd:cd15408  110 DRYVAICNPLLYT 122
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
300-370 2.51e-03

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 39.34  E-value: 2.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 205804177 300 LMVVLLVFALCYLPISV----LNVLKRVFGMFRqasdreavYACFTFSHWLVYANSAANPIIYnFLSGKFREQFK 370
Cdd:cd15105  195 IMLTVLVFLLCGLPFGIywflLFWIKDDFHVLD--------YGLYLASVVLTAVNSCANPIIY-FFVGSFRHRLK 260
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
63-157 3.38e-03

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 39.21  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIAL 142
Cdd:cd15419   17 GNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAY 96
                         90
                 ....*....|....*
gi 205804177 143 DRWYAICHPLLFKST 157
Cdd:cd15419   97 DRFIAICNPLLYPVI 111
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
64-369 3.73e-03

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 39.06  E-value: 3.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESwLFGHALCKVIPYLQAVSVSVAVLTLSFIALD 143
Cdd:cd15211   17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGT-LLVLGYRLFREGLLFLGLTVSLLSHSLIALN 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 144 RWYAICH-PLLFKS--TARRARGSILGIWAVSLAIMVPqaavmecssvLPELANRTRLFSVCDerwADDLYPKI------ 214
Cdd:cd15211   96 RYVLITKlPAVYQAlyQKRNTEWMIALSWALALGLLLP----------WLTSFRYPTKSCHDS---ADGSFAVVsvlssr 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 215 YHSCFFIVTYLAPLGLMAMAYFQIFRKLWGrqipGTTSALVRNWkrpsdqlgdleQGLSGEPQPRAraflaevkqmRARR 294
Cdd:cd15211  163 YPALLLAFTVLGQTALVLHCYFGIFRRVQI----SVKRVSVLNF-----------QIVNNLPYSRP----------RKDK 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 205804177 295 KTAKMLMVVLLVFALCYLPIsvlnVLKRVFGMFRQASdrEAVYAcftfSHWLVY-ANSAANPIIYNFLSGKFREQF 369
Cdd:cd15211  218 RLGLYVLLVCCVFLLTTEPL----VWVSLAGLFVPVP--VALQT----ASWLLFcTLFVLNPFLYTWKNEEFRRSF 283
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
63-369 3.82e-03

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 39.24  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHAL----CKVIPYLQAVSVSVAVLTLS 138
Cdd:cd15216   17 GNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGTPPgalgCKLLAFLAALFCFHAAFLLL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 139 FIALDRWYAICHPLLFkstARRARG------SILGIWAVSLAIMVPqaAVMECSSVLPELANrtrlfsvCDERWADDLYP 212
Cdd:cd15216   97 GVGVTRYLAIAHHRFY---AERLAGwpcaamLVCAAWALALAAAFP--PVLDGGGADDEDAP-------CALEQRPDGAP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 213 KiyhSCFFIVTYLAPLGLMAMAYFQIF------RKL------------WGRQIPGTTSALVRNWKRPSDQlGDLEQGLSG 274
Cdd:cd15216  165 G---ALGFLLLLAAVVGATHLVYLRLLffihdrRKMrparlvpavshdWTFHGPGATGQAAANWTAGFGR-GPTPPALVG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177 275 ----EPQPRARAFLAeVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRvfgMFRQASDREAVyacFTFSHWLVYAN 350
Cdd:cd15216  241 irpaGPGRGARRLLV-LEEFKTEKRLCKMFYAITLLFLLLWGPYVVASYLRV---LVRPGAVPQAY---LTASVWLTFAQ 313
                        330
                 ....*....|....*....
gi 205804177 351 SAANPIIYNFLSGKFREQF 369
Cdd:cd15216  314 AGINPVVCFLFNRELRDCF 332
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
63-152 4.55e-03

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 38.72  E-value: 4.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWL--FGHALCKvIPYLQAVSVSVAVLtLSFI 140
Cdd:cd15226   17 GNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTisFGGCMAQ-IFFLHFFGGSEMVL-LIAM 94
                         90
                 ....*....|..
gi 205804177 141 ALDRWYAICHPL 152
Cdd:cd15226   95 AFDRYVAICKPL 106
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
63-183 6.67e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 38.21  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNY-FIVNLSLADVLVTAICLPASL--LVDITESWLFGHALCKVIpYLQAVSVSvAVLTLSF 139
Cdd:cd15935   17 GNLLIVVTVHADPHLLQSPMYfFLANLSLIDMTLGSVAVPKVLadLLTCGRTISFGGCMAQLF-FLHFLGGS-EMLLLTL 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 205804177 140 IALDRWYAICHPLLFKSTA--RRARGSILGIWAVSLAIMVPQAAVM 183
Cdd:cd15935   95 MAYDRYVAICHPLRYLAVMnrQLCIKLLAACWAGGFLHSATQAALV 140
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
64-172 6.93e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 37.99  E-value: 6.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVT--------AICLPASLLVDITESwlFGHALCKVIPYLQAVSVSVAVL 135
Cdd:cd15354   18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSvsnawetiTIYLLNNRHLVIEDA--FVRHIDNVFDSLICISVVASMC 95
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 205804177 136 TLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVS 172
Cdd:cd15354   96 SLLAIAVDRYVTIFYALRYHNimTVRRAGIIIACIWTFC 134
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
64-151 8.28e-03

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 37.72  E-value: 8.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  64 NTLVCLAVWRNHHMRTVTNYFIVNLSLADvlvTAICLPASLLVDIT--ESWLFGHALCKVIPYLQAVSVSVAVLTLSFIA 141
Cdd:cd15072   18 NGLTILSFCKTRELRTPSNLLVLSLAVAD---MGISLNALVAASSSllRRWPYGSEGCQAHGFQGFFTALASICSSAAIA 94
                         90
                 ....*....|
gi 205804177 142 LDRWYAICHP 151
Cdd:cd15072   95 WDRYHHYCTR 104
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
63-171 8.47e-03

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 37.91  E-value: 8.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 205804177  63 GNTLVCLAVWRNHHMRTVTNY-FIVNLSLADVLVTAICLPASLLVDITESW-LFGHALCKVIPYLQAVSVSVAVLTLSFI 140
Cdd:cd15941   17 GNLLILLTIGSDPHLHGLPMYhFLGHLSFLDACLSSVTVPKVLAGLLTLSGrTISFEGCVVQLYAFHFLASTECFLYTVM 96
                         90       100       110
                 ....*....|....*....|....*....|...
gi 205804177 141 ALDRWYAICHPLLFKSTARR--ARGSILGIWAV 171
Cdd:cd15941   97 AYDRYLAICHPLHYPTAMNRrmCAGLAGGTWAT 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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