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Conserved domains on  [gi|25091514|sp|O43895|]
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RecName: Full=Xaa-Pro aminopeptidase 2; AltName: Full=Aminoacylproline aminopeptidase; AltName: Full=Membrane-bound aminopeptidase P; Short=Membrane-bound APP; Short=Membrane-bound AmP; Short=mAmP; AltName: Full=X-Pro aminopeptidase 2; Flags: Precursor

Protein Classification

aminopeptidase P family protein( domain architecture ID 11114206)

aminopeptidase P family protein (metallopeptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24B
PubMed:  16229471|30536999
SCOP:  4004278|4004281|4000535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 365-583 4.31e-125

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


:

Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 369.97  E-value: 4.31e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 365 LKASHVRDAVAVIRYLVWLEKNVPKG-TVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSS 443
Cdd:cd01085   2 MRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKISP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 444 DEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTG 523
Cdd:cd01085  82 DGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGTG 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25091514 524 HGIGNFLCVHEWPVG--FQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPG 583
Cdd:cd01085 162 HGVGSFLNVHEGPQSisPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
195-361 2.49e-59

Creatinase/Prolidase N-terminal domain;


:

Pssm-ID: 465053  Cd Length: 159  Bit Score: 196.56  E-value: 2.49e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   195 ERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQkvPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIR 274
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKG--ADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   275 LFANKSRFSSETLSYLNSSctgpmCVQIEDYSQVRDSIQAYSlGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTK 354
Cdd:pfam16189  79 LFVDPEKLSDEVRAHLEEN-----GVEIRPYDDIYEDLAALA-AGKKVLLDPSRTSYALYSALPAGAKVVEAPSPITLMK 152


                  ....*..
gi 25091514   355 AVKNSKE 361
Cdd:pfam16189 153 AVKNETE 159
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 585-648 1.00e-23

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


:

Pssm-ID: 465052  Cd Length: 63  Bit Score: 94.40  E-value: 1.00e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25091514   585 YLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQllEEFEWLQQHTEPL 648
Cdd:pfam16188   2 FLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 54-184 1.44e-15

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


:

Pssm-ID: 460159  Cd Length: 128  Bit Score: 73.49  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514    54 LTALRQQMQTQNLSAYIIPgtdahmneyigqHDERRAWITGFTGSAGTA-VVTMKKAAVWTD-SRYWTQAeRQMDCNWEL 131
Cdd:pfam01321   2 LEKLRKLMEEKGLDAALVT------------SPENLRYLTGFTGSRGLLlLVTADGALLLVDaLEYERAA-AESAPDFDV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25091514   132 HKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNrqLVSIT 184
Cdd:pfam01321  69 VPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGAE--LVDVS 119
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 365-583 4.31e-125

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 369.97  E-value: 4.31e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 365 LKASHVRDAVAVIRYLVWLEKNVPKG-TVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSS 443
Cdd:cd01085   2 MRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKISP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 444 DEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTG 523
Cdd:cd01085  82 DGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGTG 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25091514 524 HGIGNFLCVHEWPVG--FQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPG 583
Cdd:cd01085 162 HGVGSFLNVHEGPQSisPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
340-582 2.54e-60

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 204.28  E-value: 2.54e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 340 EKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVpkgtvdefSGAEIVDKFRGE--EQFSSGPSFE 417
Cdd:COG0006  57 ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGV--------TEREVAAELEAAmrRRGAEGPSFD 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 418 TISASGLNAALAHYSPTkelNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIfPAA 497
Cdd:COG0006 129 TIVASGENAAIPHYTPT---DRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPG 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 498 TSGRMVEAFARRALWDAGL--NYGHGTGHGIGnfLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVV 575
Cdd:COG0006 205 VTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHEGPQISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVT 282

                       250
                ....*....|.
gi 25091514 576 EAK----TKYP 582
Cdd:COG0006 283 EDGaevlTRLP 293
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
195-361 2.49e-59

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 196.56  E-value: 2.49e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   195 ERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQkvPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIR 274
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKG--ADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   275 LFANKSRFSSETLSYLNSSctgpmCVQIEDYSQVRDSIQAYSlGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTK 354
Cdd:pfam16189  79 LFVDPEKLSDEVRAHLEEN-----GVEIRPYDDIYEDLAALA-AGKKVLLDPSRTSYALYSALPAGAKVVEAPSPITLMK 152


                  ....*..
gi 25091514   355 AVKNSKE 361
Cdd:pfam16189 153 AVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 363-576 4.56e-50

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 173.20  E-value: 4.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   363 ALLKASHVRDAVAVIRYLVWLEKNVpkgtvDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTkelNRKLS 442
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGV-----TERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIPN---DRVLK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   443 SDEMYLLDSGGQYWDG-TTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATsGRMVEAFARRALWDAGL--NYG 519
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVT-GGDVDAAAREVLEEAGLgeYFP 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 25091514   520 HGTGHGIGnfLCVHEWP-VGFQSNNIAMAKGMFTSIEPGYYK-DGEFGIRLEDVALVVE 576
Cdd:pfam00557 152 HGLGHGIG--LEVHEGPyISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 585-648 1.00e-23

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 94.40  E-value: 1.00e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25091514   585 YLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQllEEFEWLQQHTEPL 648
Cdd:pfam16188   2 FLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
 408-576 2.53e-18

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 87.30  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  408 EQFSSGPSFETISASGLNAALAHyspTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKE-----AYTRV 482
Cdd:PRK09795 173 QQGAEKASFDTIVASGWRGALPH---GKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIV 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  483 LIGNIDLSRLIFPAaTSGRMVEAFARRALWDAGLN--YGHGTGHGIGnfLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYK 560
Cdd:PRK09795 250 LQAQLAAISAIRPG-VRCQQVDDAARRVITEAGYGdyFGHNTGHAIG--IEVHEDPRFSPRDTTTLQPGMLLTVEPGIYL 326

                        170
                 ....*....|....*.
gi 25091514  561 DGEFGIRLEDVALVVE 576
Cdd:PRK09795 327 PGQGGVRIEDVVLVTP 342
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 54-184 1.44e-15

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 73.49  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514    54 LTALRQQMQTQNLSAYIIPgtdahmneyigqHDERRAWITGFTGSAGTA-VVTMKKAAVWTD-SRYWTQAeRQMDCNWEL 131
Cdd:pfam01321   2 LEKLRKLMEEKGLDAALVT------------SPENLRYLTGFTGSRGLLlLVTADGALLLVDaLEYERAA-AESAPDFDV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25091514   132 HKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNrqLVSIT 184
Cdd:pfam01321  69 VPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGAE--LVDVS 119
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 365-583 4.31e-125

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 369.97  E-value: 4.31e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 365 LKASHVRDAVAVIRYLVWLEKNVPKG-TVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSS 443
Cdd:cd01085   2 MRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKISP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 444 DEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTG 523
Cdd:cd01085  82 DGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGTG 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25091514 524 HGIGNFLCVHEWPVG--FQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPG 583
Cdd:cd01085 162 HGVGSFLNVHEGPQSisPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
340-582 2.54e-60

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 204.28  E-value: 2.54e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 340 EKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVpkgtvdefSGAEIVDKFRGE--EQFSSGPSFE 417
Cdd:COG0006  57 ERELVDASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGV--------TEREVAAELEAAmrRRGAEGPSFD 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 418 TISASGLNAALAHYSPTkelNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIfPAA 497
Cdd:COG0006 129 TIVASGENAAIPHYTPT---DRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPG 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 498 TSGRMVEAFARRALWDAGL--NYGHGTGHGIGnfLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVV 575
Cdd:COG0006 205 VTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHEGPQISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVT 282

                       250
                ....*....|.
gi 25091514 576 EAK----TKYP 582
Cdd:COG0006 283 EDGaevlTRLP 293
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
195-361 2.49e-59

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 196.56  E-value: 2.49e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   195 ERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQkvPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIR 274
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKG--ADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   275 LFANKSRFSSETLSYLNSSctgpmCVQIEDYSQVRDSIQAYSlGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTK 354
Cdd:pfam16189  79 LFVDPEKLSDEVRAHLEEN-----GVEIRPYDDIYEDLAALA-AGKKVLLDPSRTSYALYSALPAGAKVVEAPSPITLMK 152


                  ....*..
gi 25091514   355 AVKNSKE 361
Cdd:pfam16189 153 AVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 363-576 4.56e-50

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 173.20  E-value: 4.56e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   363 ALLKASHVRDAVAVIRYLVWLEKNVpkgtvDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTkelNRKLS 442
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGV-----TERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIPN---DRVLK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514   443 SDEMYLLDSGGQYWDG-TTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATsGRMVEAFARRALWDAGL--NYG 519
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVT-GGDVDAAAREVLEEAGLgeYFP 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 25091514   520 HGTGHGIGnfLCVHEWP-VGFQSNNIAMAKGMFTSIEPGYYK-DGEFGIRLEDVALVVE 576
Cdd:pfam00557 152 HGLGHGIG--LEVHEGPyISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 398-576 3.89e-38

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 140.34  E-value: 3.89e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 398 AEIVDKFRgeEQFSSGPSFETISASGLNAALAHYSPTkelNRKLSSDEMYLLDSGGqYWDG-TTDITRTVHWGTPSAFQK 476
Cdd:cd01092  33 AELEYFMR--KLGAEGPSFDTIVASGPNSALPHGVPS---DRKIEEGDLVLIDFGA-IYDGyCSDITRTVAVGEPSDELK 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 477 EAYTRVLIGN---IDLSRlifPAATsGRMVEAFARRALWDAGL--NYGHGTGHGIGnfLCVHEWPVGFQSNNIAMAKGMF 551
Cdd:cd01092 107 EIYEIVLEAQqaaIKAVK---PGVT-AKEVDKAARDVIEEAGYgeYFIHRTGHGVG--LEVHEAPYISPGSDDVLEEGMV 180

                       170       180
                ....*....|....*....|....*
gi 25091514 552 TSIEPGYYKDGEFGIRLEDVALVVE 576
Cdd:cd01092 181 FTIEPGIYIPGKGGVRIEDDVLVTE 205
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 412-579 1.84e-28

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 113.32  E-value: 1.84e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 412 SGPSFETISASGLNAALAHYSPTkelNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSR 491
Cdd:cd01066  44 GYPAGPTIVGSGARTALPHYRPD---DRRLQEGDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALA 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 492 LIFPAATsGRMVEAFARRAL--WDAGLNYGHGTGHGIGnfLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLE 569
Cdd:cd01066 121 ALRPGVT-AEEVDAAAREVLeeHGLGPNFGHRTGHGIG--LEIHEPPVLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIE 197

                       170
                ....*....|
gi 25091514 570 DVALVVEAKT 579
Cdd:cd01066 198 DTVLVTEDGP 207
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
 585-648 1.00e-23

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 94.40  E-value: 1.00e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25091514   585 YLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQllEEFEWLQQHTEPL 648
Cdd:pfam16188   2 FLGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
 408-576 2.53e-18

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 87.30  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  408 EQFSSGPSFETISASGLNAALAHyspTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKE-----AYTRV 482
Cdd:PRK09795 173 QQGAEKASFDTIVASGWRGALPH---GKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfnVYQIV 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  483 LIGNIDLSRLIFPAaTSGRMVEAFARRALWDAGLN--YGHGTGHGIGnfLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYK 560
Cdd:PRK09795 250 LQAQLAAISAIRPG-VRCQQVDDAARRVITEAGYGdyFGHNTGHAIG--IEVHEDPRFSPRDTTTLQPGMLLTVEPGIYL 326

                        170
                 ....*....|....*.
gi 25091514  561 DGEFGIRLEDVALVVE 576
Cdd:PRK09795 327 PGQGGVRIEDVVLVTP 342
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 414-576 7.46e-16

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 77.61  E-value: 7.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 414 PSFETISASGLNAALAHYSptkELNRKLSSDEMYLLDSGGQYWDGTTDITRTvhW---GTPSAFQKEAYTRVLIGNIDLS 490
Cdd:cd01087  46 LAYSYIVAAGSNAAILHYV---HNDQPLKDGDLVLIDAGAEYGGYASDITRT--FpvnGKFTDEQRELYEAVLAAQKAAI 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514 491 RLIFPAATSGRMVEAFARRA---LWDAGLNYG----------------HGTGHGIGnfLCVHEWPVGFQSN--NIAMAKG 549
Cdd:cd01087 121 AACKPGVSYEDIHLLAHRVLaegLKELGILKGdvdeivesgayakffpHGLGHYLG--LDVHDVGGYLRYLrrARPLEPG 198

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 25091514 550 MFTSIEPGYY------KDGEF----GIRLEDVALVVE 576
Cdd:cd01087 199 MVITIEPGIYfipdllDVPEYfrggGIRIEDDVLVTE 235
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
 54-184 1.44e-15

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 73.49  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514    54 LTALRQQMQTQNLSAYIIPgtdahmneyigqHDERRAWITGFTGSAGTA-VVTMKKAAVWTD-SRYWTQAeRQMDCNWEL 131
Cdd:pfam01321   2 LEKLRKLMEEKGLDAALVT------------SPENLRYLTGFTGSRGLLlLVTADGALLLVDaLEYERAA-AESAPDFDV 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 25091514   132 HKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNrqLVSIT 184
Cdd:pfam01321  69 VPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGAE--LVDVS 119
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 414-577 9.80e-08

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 54.73  E-value: 9.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  414 PSFETISASGLNAALAHYSptkELNRKLSSDEMYLLDSGGQYWDGTTDITRT--VHwGTPSAFQKEAYTRVLiGNIDLSR 491
Cdd:PRK10879 225 PSYNTIVGSGENGCILHYT---ENESEMRDGDLVLIDAGCEYKGYAGDITRTfpVN-GKFTPAQREIYDIVL-ESLETSL 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  492 LIFPAATSGRMVEAFARR----ALWDAGLNYG----------------HGTGHGIGnfLCVHEwpVGF--QSNNIAMAKG 549
Cdd:PRK10879 300 RLYRPGTSIREVTGEVVRimvsGLVKLGILKGdvdqliaenahrpffmHGLSHWLG--LDVHD--VGVygQDRSRILEPG 375

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 25091514  550 MFTSIEPGYY--KDGE-------FGIRLEDVALVVEA 577
Cdd:PRK10879 376 MVLTVEPGLYiaPDADvpeqyrgIGIRIEDDIVITET 412
PRK15173 PRK15173
peptidase; Provisional
 438-588 3.45e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 46.25  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  438 NRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAAtsgRMVEAF--ARRALWDAG 515
Cdd:PRK15173 167 NTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGV---KMKDVFdsTMEVIKKSG 243

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25091514  516 L-NYGHG-TGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALV----VEAKTKYPGSYLTF 588
Cdd:PRK15173 244 LpNYNRGhLGHGNGVFLGLEESPFVSTHATESFTSGMVLSLETPYYGYNLGSIMIEDMILInkegIEFLSKLPRDLVSF 322
PRK14575 PRK14575
putative peptidase; Provisional
 438-588 5.54e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 46.24  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  438 NRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAAtsgRMVEAF--ARRALWDAG 515
Cdd:PRK14575 250 NTKACSGDLIKFDCGVDVDGYGADIARTFVVGEPPEITRKIYQTIRTGHEHMLSMVAPGV---KMKDVFdsTMEVIKKSG 326

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25091514  516 L-NYGHG-TGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALV----VEAKTKYPGSYLTF 588
Cdd:PRK14575 327 LpNYNRGhLGHGNGVFLGLEESPFVSTHATESFTSGMVLSLETPYYGYNLGSIMIEDMILInkegIEFLSKLPRDLVSF 405
PRK14576 PRK14576
putative endopeptidase; Provisional
 461-576 1.64e-03

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 41.54  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25091514  461 DITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAfARRALWDAGL---NYGHgTGHGIGNFLCVHEWPV 537
Cdd:PRK14576 272 DLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDS-TMAVIKTSGLphyNRGH-LGHGDGVFLGLEEVPF 349

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 25091514  538 GFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVE 576
Cdd:PRK14576 350 VSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILITD 388
HemE COG0407
Uroporphyrinogen-III decarboxylase HemE [Coenzyme transport and metabolism]; ...
 466-526 7.58e-03

Uroporphyrinogen-III decarboxylase HemE [Coenzyme transport and metabolism]; Uroporphyrinogen-III decarboxylase HemE is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440176 [Multi-domain]  Cd Length: 336  Bit Score: 39.05  E-value: 7.58e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25091514 466 VHWGTPSAFQKEAY--TRVLIGNIDLSRLIFPAatSGRMVEAFARRALWDAGLNYGH--GTGHGI 526
Cdd:COG0407 254 VDWRVDLAEAKERLgdKVALQGNLDPALLLLNG--TPEEVEAEVKRILDAGGGGPGHifNLGHGI 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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