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Conserved domains on  [gi|6647536|sp|O51378|]
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RecName: Full=Adenylate kinase; Short=AK; AltName: Full=ATP-AMP transphosphorylase; AltName: Full=ATP:AMP phosphotransferase; AltName: Full=Adenylate monophosphate kinase

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11487310)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14526 PRK14526
adenylate kinase; Provisional
 1-194 1.22e-123

adenylate kinase; Provisional


:

Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 348.38  E-value: 1.22e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE 160
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKE 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 6647536   161 ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASV 194
Cdd:PRK14526 161 ESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASK 194
 
Name Accession Description Interval E-value
PRK14526 PRK14526
adenylate kinase; Provisional
 1-194 1.22e-123

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 348.38  E-value: 1.22e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE 160
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKE 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 6647536   161 ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASV 194
Cdd:PRK14526 161 ESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASK 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-193 1.14e-94

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 274.70  E-value: 1.14e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:COG0563   1 MRIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536   81 FILDGFPRNICQAEALDKFLP--NVKI---INFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQR 155
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAelGIKLdavIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6647536  156 EDDKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDAS 193
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 3-192 2.34e-93

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 271.42  E-value: 2.34e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKN-KDF 81
Cdd:TIGR01351   2 LVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNeNGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     82 ILDGFPRNICQAEALDKFL--PNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDK 159
Cdd:TIGR01351  82 ILDGFPRTLSQAEALDALLeePIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDT 161

                         170       180       190
                  ....*....|....*....|....*....|...
gi 6647536    160 EECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:TIGR01351 162 EEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDG 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 3-193 1.10e-78

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 233.67  E-value: 1.10e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFI 82
Cdd:cd01428   2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536   83 LDGFPRNICQAEALDKFL----PNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIytlttkknGICDVCGGDLYQREDD 158
Cdd:cd01428  82 LDGFPRTVDQAEALDELLdegiKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDD 153

                       170       180       190
                ....*....|....*....|....*....|....*
gi 6647536  159 KEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDAS 193
Cdd:cd01428 154 NEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGS 188
ADK pfam00406
Adenylate kinase;
5-183 5.44e-77

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 229.12  E-value: 5.44e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      5 FLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFILD 84
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     85 GFPRNICQAEALDKFLPNVK----IINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE 160
Cdd:pfam00406  81 GFPRTVPQAEALEELLERGIkldyVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|...
gi 6647536    161 ECLKTRLKEYKLQTKPLIEFYSK 183
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKK 183
 
Name Accession Description Interval E-value
PRK14526 PRK14526
adenylate kinase; Provisional
 1-194 1.22e-123

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 348.38  E-value: 1.22e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE 160
Cdd:PRK14526  81 FILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDDKE 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 6647536   161 ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASV 194
Cdd:PRK14526 161 ESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASK 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-193 1.14e-94

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 274.70  E-value: 1.14e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:COG0563   1 MRIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536   81 FILDGFPRNICQAEALDKFLP--NVKI---INFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQR 155
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAelGIKLdavIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6647536  156 EDDKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDAS 193
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 3-192 2.34e-93

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 271.42  E-value: 2.34e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKN-KDF 81
Cdd:TIGR01351   2 LVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNeNGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     82 ILDGFPRNICQAEALDKFL--PNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDK 159
Cdd:TIGR01351  82 ILDGFPRTLSQAEALDALLeePIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDT 161

                         170       180       190
                  ....*....|....*....|....*....|...
gi 6647536    160 EECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:TIGR01351 162 EEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDG 194
adk PRK00279
adenylate kinase; Reviewed
 1-192 1.87e-88

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 259.31  E-value: 1.87e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFL--PNVKI---INFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQR 155
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLkeLGIKLdavIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 6647536   156 EDDKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDG 197
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 3-193 1.10e-78

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 233.67  E-value: 1.10e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFI 82
Cdd:cd01428   2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536   83 LDGFPRNICQAEALDKFL----PNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIytlttkknGICDVCGGDLYQREDD 158
Cdd:cd01428  82 LDGFPRTVDQAEALDELLdegiKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSDD 153

                       170       180       190
                ....*....|....*....|....*....|....*
gi 6647536  159 KEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDAS 193
Cdd:cd01428 154 NEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGS 188
ADK pfam00406
Adenylate kinase;
5-183 5.44e-77

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 229.12  E-value: 5.44e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      5 FLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFILD 84
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     85 GFPRNICQAEALDKFLPNVK----IINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE 160
Cdd:pfam00406  81 GFPRTVPQAEALEELLERGIkldyVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|...
gi 6647536    161 ECLKTRLKEYKLQTKPLIEFYSK 183
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKK 183
PLN02674 PLN02674
adenylate kinase
 3-192 9.85e-50

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 161.98  E-value: 9.85e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFI 82
Cdd:PLN02674  34 LILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    83 LDGFPRNICQAEALDKFLPNV-----KIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQRED 157
Cdd:PLN02674 114 LDGFPRTVVQAQKLDEMLAKQgakidKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKD 193

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 6647536   158 DKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:PLN02674 194 DTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHA 228
PLN02459 PLN02459
probable adenylate kinase
 4-183 1.70e-48

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 159.24  E-value: 1.70e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     4 VFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD--F 81
Cdd:PLN02459  33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEGEsgF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    82 ILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTK-KNGICDV----------CGG 150
Cdd:PLN02459 113 ILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKCLGRRICSECGKNFNVADIDLKgEDGRPGIvmppllpppeCAS 192

                        170       180       190
                 ....*....|....*....|....*....|...
gi 6647536   151 DLYQREDDKEECLKTRLKEYKLQTKPLIEFYSK 183
Cdd:PLN02459 193 KLITRADDTEEVVKARLRVYKEESQPVEDFYRK 225
PRK14530 PRK14530
adenylate kinase; Provisional
 3-191 2.00e-48

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 157.64  E-value: 2.00e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFREN-ILNSTALGQEI---KKIVERGELVPDLITIKIVEDkikAIKKN 78
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANkQMDISDMDTEYdtpGEYMDAGELVPDAVVNEIVEE---ALSDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    79 KDFILDGFPRNICQAEALDKfLPNVKIINFL-IDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQRED 157
Cdd:PRK14530  83 DGFVLDGYPRNLEQAEYLES-ITDLDVVLYLdVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGELIQRDD 161

                        170       180       190
                 ....*....|....*....|....*....|....
gi 6647536   158 DKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVD 191
Cdd:PRK14530 162 DTEETVRERLDVFEENTEPVIEHYRDQGVLVEVD 195
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-191 1.04e-45

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 151.11  E-value: 1.04e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKN-- 78
Cdd:PTZ00088   7 LKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDDcf 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    79 KDFILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGI--------CDVCGG 150
Cdd:PTZ00088  87 KGFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIAHIRSDPYDMppilppadCEGCKG 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 6647536   151 D--LYQREDDKEECLKTRLKEYKLQTKPLIEFYSKcSRLNNVD 191
Cdd:PTZ00088 167 NpkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKN-ENCNLVD 208
adk PRK02496
adenylate kinase; Provisional
 2-191 1.58e-44

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 146.43  E-value: 1.58e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     2 GLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDF 81
Cdd:PRK02496   3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    82 ILDGFPRNICQAEALDKFLPNV-----KIINFLIDEELVIKRLSGRrickscnnifniytlttkkngicdvcggdlyQRE 156
Cdd:PRK02496  83 ILDGFPRKVTQAAFLDELLQEIgqsgeRVVNLDVPDDVVVERLLAR-------------------------------GRK 131

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 6647536   157 DDKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVD 191
Cdd:PRK02496 132 DDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTID 166
PRK14527 PRK14527
adenylate kinase; Provisional
 3-191 2.18e-41

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 138.77  E-value: 2.18e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKdFI 82
Cdd:PRK14527   9 VIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVR-VI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    83 LDGFPRNICQAEALDKFL-----PNVKIINFLIDEELVIKRLSGRrickscnnifniytlttkkngicdvcgGDLYQRED 157
Cdd:PRK14527  88 FDGFPRTLAQAEALDRLLeelgaRLLAVVLLEVPDEELIRRIVER---------------------------ARQEGRSD 140

                        170       180       190
                 ....*....|....*....|....*....|....
gi 6647536   158 DKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVD 191
Cdd:PRK14527 141 DNEETVRRRQQVYREQTQPLVDYYEARGHLKRVD 174
PRK14528 PRK14528
adenylate kinase; Provisional
 3-191 2.75e-40

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 135.91  E-value: 2.75e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFI 82
Cdd:PRK14528   4 IIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    83 LDGFPRNICQAEALDKFLPNV-----KIINFLIDEELVIKRLSGRRIckscnnifniytlttkKNGicdvcggdlyqRED 157
Cdd:PRK14528  84 LDGFPRTVEQADALDALLKNEgksidKAINLEVPDGELLKRLLGRAE----------------IEG-----------RAD 136

                        170       180       190
                 ....*....|....*....|....*....|....
gi 6647536   158 DKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVD 191
Cdd:PRK14528 137 DNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVN 170
PRK14529 PRK14529
adenylate kinase; Provisional
 1-161 3.41e-40

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 136.77  E-value: 3.41e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNkD 80
Cdd:PRK14529   1 MNILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKN-G 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFL--PNVK---IINFLIDEELVIKRLSGRRICKSCNN-IFNIYTLTTKKNG-ICDVCGGDLY 153
Cdd:PRK14529  80 WLLDGFPRNKVQAEKLWEALqkEGMKldyVIEILLPREVAKNRIMGRRLCKNDNNhPNNIFIDAIKPDGdVCRVCGGELS 159


                 ....*...
gi 6647536   154 QREDDKEE 161
Cdd:PRK14529 160 TRADDQDE 167
PRK14532 PRK14532
adenylate kinase; Provisional
 1-191 1.92e-39

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 133.79  E-value: 1.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:PRK14532   1 MNLILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFLP--NVKI---INFLIDEELVIKRLSGRrickscnnifniytltTKKNGicdvcggdlyqR 155
Cdd:PRK14532  81 AIFDGFPRTVAQAEALDKMLAsrGQKIdvvIRLKVDDEALIERIVKR----------------FEEQG-----------R 133

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 6647536   156 EDDKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVD 191
Cdd:PRK14532 134 PDDNPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVD 169
PRK14531 PRK14531
adenylate kinase; Provisional
 3-192 1.99e-38

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 131.09  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIkKNKDFI 82
Cdd:PRK14531   5 LLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKAL-NSGGWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    83 LDGFPRNICQAEALDKFLPNVK-----IINFLIDEELVIKRLSGRrickscnnifniytlttkkngicdvcggdlyQRED 157
Cdd:PRK14531  84 LDGFPRTVAQAEALEPLLEELKqpieaVVLLELDDAVLIERLLAR-------------------------------GRAD 132

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 6647536   158 DKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:PRK14531 133 DNEAVIRNRLEVYREKTAPLIDHYRQRGLLQSVEA 167
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 6-193 7.86e-33

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 116.70  E-value: 7.86e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      6 LGPPGSGKGTISKIISNEFKYQHISTGDLFRENI-LNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFILD 84
Cdd:TIGR01359   5 LGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIkREGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     85 GFPRNicqAEALDKFLPNVK-------IINFLIDEELVIKRLSGRrickscnnifniytlttkkngicdvcgGDLYQRED 157
Cdd:TIGR01359  85 GFPRN---EENLEAWEKLMDnkvnfkfVLFFDCPEETMIKRLLKR---------------------------GQTSGRVD 134

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 6647536    158 DKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDAS 193
Cdd:TIGR01359 135 DNIETLKKRFRTYNEETLPIIEHFENKGKVKEINAE 170
PRK13808 PRK13808
adenylate kinase; Provisional
 1-191 1.61e-31

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 116.91  E-value: 1.61e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD 80
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    81 FILDGFPRNICQAEALDKFLPNVKI-----INFLIDEELVIKRLSgRRICKscnnifniytltTKKNGicdvcggdLYQR 155
Cdd:PRK13808  81 FILDGFPRTVPQAEALDALLKDKQLkldavVELRVNEGALLARVE-TRVAE------------MRARG--------EEVR 139

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 6647536   156 EDDKEECLKTRLKEYKLQTKPLIEFYSKCSRLNNVD 191
Cdd:PRK13808 140 ADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVD 175
AAA_17 pfam13207
AAA domain;
6-123 2.30e-29

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 106.17  E-value: 2.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      6 LGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTalGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDFILDG 85
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6647536     86 FPRNICQAEALDKFLPNV-------KIINFLIDEELVIKRLSGRR 123
Cdd:pfam13207  79 HPRIKTPAGYLPGLPVEVlrelkpdAIILLEADPEEILERRLKDR 123
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 6-192 1.05e-27

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 103.36  E-value: 1.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      6 LGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKI-KAIKKNKDFILD 84
Cdd:TIGR01360   9 VGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMvAALGTSKGFLID 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     85 GFPRNICQAEALDKFLPNVKIINFL-IDEELVIKRLSGRrickscnnifniytlttkkngicdvcgGDLYQREDDKEECL 163
Cdd:TIGR01360  89 GYPREVKQGEEFERRIGPPTLVLYFdCSEDTMVKRLLKR---------------------------AETSGRVDDNEKTI 141

                         170       180
                  ....*....|....*....|....*....
gi 6647536    164 KTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:TIGR01360 142 KKRLETYYKATEPVIAYYETKGKLRKINA 170
PLN02842 PLN02842
nucleotide kinase
 7-193 1.06e-27

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 109.18  E-value: 1.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     7 GPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKI-KAIKKNKDFILDG 85
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLsREDAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    86 FPRNICQAEALDKF--LPNVKIInFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGIcdvcGGDLYQREDDKEECL 163
Cdd:PLN02842  84 YPRSFAQAQSLEKLkiRPDIFIL-LDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPESEEI----KARLITRPDDTEEKV 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 6647536   164 KTRLKEYKLQTKPLIEFYSKCsrLNNVDAS 193
Cdd:PLN02842 159 KARLQIYKKNAEAILSTYSDI--MVKIDGN 186
PLN02200 PLN02200
adenylate kinase family protein
 6-192 1.09e-19

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 83.79  E-value: 1.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     6 LGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKdFILDG 85
Cdd:PLN02200  49 LGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK-FLIDG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    86 FPR---NICQAEALDKFLPNVkIINFLIDEELVIKRLSGRRickscnnifniytlttkkngicdvcggdlYQREDDKEEC 162
Cdd:PLN02200 128 FPRteeNRIAFERIIGAEPNV-VLFFDCPEEEMVKRVLNRN-----------------------------QGRVDDNIDT 177

                        170       180       190
                 ....*....|....*....|....*....|
gi 6647536   163 LKTRLKEYKLQTKPLIEFYSKCSRLNNVDA 192
Cdd:PLN02200 178 IKKRLKVFNALNLPVIDYYSKKGKLYTINA 207
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 122-157 2.61e-13

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 61.71  E-value: 2.61e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6647536    122 RRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQRED 157
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 7-85 5.31e-10

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 55.57  E-value: 5.31e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6647536    7 GPPGSGKGTISKIISNEFKYQHISTGDLfrenilnstaLGQEIKKIVERGELVPDlITIKIVEdKIKAIKKNKDFILDG 85
Cdd:cd02020   6 GPAGSGKSTVAKLLAKKLGLPYLDTGGI----------RTEEVGKLASEVAAIPE-VRKALDE-RQRELAKKPGIVLEG 72
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-85 3.24e-09

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 53.97  E-value: 3.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFREnilNSTALGQEIKKIVERGELVPDlITIKIVEDKIKAIKKNKD 80
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFRE---LAAKMGLDLIEFLNYAEENPE-IDKKIDRRIHEIALKEKN 76


                  ....*
gi 6647536     81 FILDG 85
Cdd:TIGR02173  77 VVLES 81
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-37 1.32e-07

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 49.42  E-value: 1.32e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 6647536     1 MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRE 37
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 3-55 4.35e-05

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 43.53  E-value: 4.35e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQhistgdlFREniLNSTALG-QEIKKIVER 55
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAP-------FEA--LSAVTSGvKDLREVIEE 83
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
7-36 5.78e-05

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 42.32  E-value: 5.78e-05
                        10        20        30
                ....*....|....*....|....*....|
gi 6647536    7 GPPGSGKGTISKIISNEFKYQHISTGDLFR 36
Cdd:COG0283   7 GPAGSGKSTVAKALAKRLGYHYLDTGAMYR 36
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 7-36 2.75e-04

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 40.37  E-value: 2.75e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 6647536      7 GPPGSGKGTISKIISNEFKYQHISTGDLFR 36
Cdd:pfam02224   5 GPSGSGKSTVARILARKLGYKYLDTGAMYR 34
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 4-123 3.09e-04

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 40.33  E-value: 3.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    4 VFLGPPGSGKGTISKIISNEFK---YQHISTgdlfREniLNSTALGQEIKKIVERGE-LVPDLIT---------IKIVED 70
Cdd:cd01672   4 VFEGIDGAGKTTLIELLAERLEargYEVVLT----RE--PGGTPIGEAIRELLLDPEdEKMDPRAelllfaadrAQHVEE 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6647536   71 KIK-AIKKNKDFILD----------GFPRNICQAE-------ALDKFLPNVKIInFLIDEELVIKRLSGRR 123
Cdd:cd01672  78 VIKpALARGKIVLSDrfvdsslayqGAGRGLGEALiealndlATGGLKPDLTIL-LDIDPEVGLARIEARG 147
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 1-118 4.28e-04

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 39.71  E-value: 4.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    1 MGLVFLGPPGSGKGTISKIISNEFKYQ-----HISTgDLFRENILNSTALGQeikkivERGELVPDlitikIVEDKIK-A 74
Cdd:COG4088   5 MLLILTGPPGSGKTTFAKALAQRLYAEgiavaLLHS-DDFRRFLVNESFPKE------TYEEVVED-----VRTTTADnA 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6647536   75 IKKNKDFILDG-FPRNICQA--EALDKFLPNVKIINFLIDEELVIKR 118
Cdd:COG4088  73 LDNGYSVIVDGtFYYRSWQRdfRNLAKHKAPIHIIYLKAPLETALRR 119
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
1-122 6.22e-04

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 39.16  E-value: 6.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536     1 MGLVFLGPPGSGKGTISKIISnEFKYQHISTGDLFRENILNstaLGQEIKK-------IVERGELVPDLITIKIVEdKIK 73
Cdd:PRK01184   2 KIIGVVGMPGSGKGEFSKIAR-EMGIPVVVMGDVIREEVKK---RGLEPTDenigkvaIDLRKELGMDAVAKRTVP-KIR 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6647536    74 AiKKNKDFILDGFpRNICQAEALDKFLP-NVKIINFLIDEELVIKRLSGR 122
Cdd:PRK01184  77 E-KGDEVVVIDGV-RGDAEVEYFRKEFPeDFILIAIHAPPEVRFERLKKR 124
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 3-122 1.44e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 37.67  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      3 LVFL-GPPGSGKGTISKIISNEFKYQHISTgDLFRENILNstALGQEIKKIVERGELVPDLItIKIVEdkiKAIKKNKDF 81
Cdd:pfam13671   1 LILLvGLPGSGKSTLARRLLEELGAVRLSS-DDERKRLFG--EGRPSISYYTDATDRTYERL-HELAR---IALRAGRPV 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 6647536     82 ILDGFPRNICQAEALDKFLP----NVKIINFLIDEELVIKRLSGR 122
Cdd:pfam13671  74 ILDATNLRRDERARLLALAReygvPVRIVVFEAPEEVLRERLAAR 118
PRK13341 PRK13341
AAA family ATPase;
3-56 1.48e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 38.88  E-value: 1.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6647536     3 LVFLGPPGSGKGTISKIISNEFKYQHIStgdlfreniLNSTALG-QEIKKIVERG 56
Cdd:PRK13341  55 LILYGPPGVGKTTLARIIANHTRAHFSS---------LNAVLAGvKDLRAEVDRA 100
AAA_18 pfam13238
AAA domain;
7-122 1.71e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 37.02  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536      7 GPPGSGKGTISKIISNEFKYqHISTGDLFRENILNST--ALGQEIKKIVERGelvpDLITIKIVEdKIKAIKKNKDFILD 84
Cdd:pfam13238   5 GTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGddPETRESKRLDEDK----LDRLLDLLE-ENAALEEGGNLIID 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 6647536     85 GFPrniCQAEAlDKFLPNVKIINFLIDEELvIKRLSGR 122
Cdd:pfam13238  79 GHL---AELEP-ERAKDLVGIVLRASPEEL-LERLEKR 111
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
7-85 5.20e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 36.34  E-value: 5.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6647536    7 GPPGSGKGTISKIISNEFKYQHIStGDLFRE---------NILNstALGQEIKKIVERGELVPDLItIKIVEDKIKAIKK 77
Cdd:COG1102   7 REPGSGGTTIAKRLAEKLGLPLYD-GEILREaakerglseEEFE--KLDEKAPSLLYRDTAEEDEI-DRALDKVIRELAR 82


                ....*...
gi 6647536   78 NKDFILDG 85
Cdd:COG1102  83 KGNCVIVG 90
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 2-30 7.29e-03

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 35.95  E-value: 7.29e-03
                        10        20
                ....*....|....*....|....*....
gi 6647536    2 GLVFLGPPGSGKGTISKIISNEFKYQHIS 30
Cdd:cd19528  29 GVLFYGPPGCGKTLLAKAIANECQANFIS 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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