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Conserved domains on  [gi|12644074|sp|O60739|]
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RecName: Full=Eukaryotic translation initiation factor 1b; Short=eIF1b; AltName: Full=Protein translation factor SUI1 homolog GC20

Protein Classification

SUI1 family translation initiation factor( domain architecture ID 960)

SUI1 family translation initiation factor is involved in the regulation of translation initiation, recognizing the start codon on mRNA by the ribosome and interacting with other components of the translation initiation complex to facilitate the assembly of the translation machinery.

Gene Ontology:  GO:0003723|GO:0003743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF1_SUI1_like super family cl00229
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 4-113 1.78e-55

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


The actual alignment was detected with superfamily member TIGR01160:

Pssm-ID: 469673  Cd Length: 110  Bit Score: 168.09  E-value: 1.78e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074     4 IQNLQSFDPFADATKGDDLLPaGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVI 83
Cdd:TIGR01160   2 IQNLKSFDPFADAGDDDSALP-GTSNYIHIRIQQRNGRKTLTTVQGLPKEYDLKKIVKALKKEFACNGTVIEDPEMGEVI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 12644074    84 QLQGDQRKNICQFLLEVGIVKEEQLKVHGF 113
Cdd:TIGR01160  81 QLQGDQRKNVCEFLISQGLLKKDQIKIHGF 110
 
Name Accession Description Interval E-value
SUI1_MOF2 TIGR01160
translation initiation factor SUI1, eukaryotic; Alternate name: MOF2. A similar protein family ...
 4-113 1.78e-55

translation initiation factor SUI1, eukaryotic; Alternate name: MOF2. A similar protein family (see TIGRFAMs model TIGR01158) is found in prokaryotes. The human proteins complements a yeast SUI1 mutatation. [Protein synthesis, Translation factors]


Pssm-ID: 130228  Cd Length: 110  Bit Score: 168.09  E-value: 1.78e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074     4 IQNLQSFDPFADATKGDDLLPaGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVI 83
Cdd:TIGR01160   2 IQNLKSFDPFADAGDDDSALP-GTSNYIHIRIQQRNGRKTLTTVQGLPKEYDLKKIVKALKKEFACNGTVIEDPEMGEVI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 12644074    84 QLQGDQRKNICQFLLEVGIVKEEQLKVHGF 113
Cdd:TIGR01160  81 QLQGDQRKNVCEFLISQGLLKKDQIKIHGF 110
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 29-112 1.48e-45

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 141.90  E-value: 1.48e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074  29 DYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLLEVGIVKEEQL 108
Cdd:cd11566   1 GYIHIRIQQRNGRKTLTTVQGLPEEFDLKKILKAFKKEFACNGTVVEDPEYGEVIQLQGDQRKNIKEFLLEEGIAKKDNI 80


                ....
gi 12644074 109 KVHG 112
Cdd:cd11566  81 KVHG 84
SUI1 pfam01253
Translation initiation factor SUI1;
30-102 3.66e-22

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 82.48  E-value: 3.66e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12644074    30 YIHIRIQQRNGRKTLTTVQGI-ADDYDKKKLVKAFKKKFACNGTVIEHPeYGEVIQLQGDQRKNICQFLLEVGI 102
Cdd:pfam01253   3 KIHIRVEQRGGRKTVTTVSGLePFGIDLKKLAKELKKKFACGGTVVKDG-GGEEIQVQGDQRDKVAELLTEKGI 75
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
31-109 2.32e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 37.21  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074   31 IHIRIQQRNGRKTLTTVQGI-ADDYDKKKLVKAFKKKFACNGTViehpeYGEVIQLQGDQRKNICQFLLEVGIvKEEQLK 109
Cdd:PRK00939  26 IKIKVDKRRYGKEVTIIEGIdPKDIDLKELAKKLKSKLACGGTV-----KDGRIELQGDHRERVKELLIKMGF-SEENIE 99
 
Name Accession Description Interval E-value
SUI1_MOF2 TIGR01160
translation initiation factor SUI1, eukaryotic; Alternate name: MOF2. A similar protein family ...
 4-113 1.78e-55

translation initiation factor SUI1, eukaryotic; Alternate name: MOF2. A similar protein family (see TIGRFAMs model TIGR01158) is found in prokaryotes. The human proteins complements a yeast SUI1 mutatation. [Protein synthesis, Translation factors]


Pssm-ID: 130228  Cd Length: 110  Bit Score: 168.09  E-value: 1.78e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074     4 IQNLQSFDPFADATKGDDLLPaGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVI 83
Cdd:TIGR01160   2 IQNLKSFDPFADAGDDDSALP-GTSNYIHIRIQQRNGRKTLTTVQGLPKEYDLKKIVKALKKEFACNGTVIEDPEMGEVI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 12644074    84 QLQGDQRKNICQFLLEVGIVKEEQLKVHGF 113
Cdd:TIGR01160  81 QLQGDQRKNVCEFLISQGLLKKDQIKIHGF 110
eIF1_SUI1 cd11566
Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important ...
 29-112 1.48e-45

Eukaryotic initiation factor 1; eIF1/SUI1 (eukaryotic initiation factor 1) plays an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown.


Pssm-ID: 211318  Cd Length: 84  Bit Score: 141.90  E-value: 1.48e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074  29 DYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLLEVGIVKEEQL 108
Cdd:cd11566   1 GYIHIRIQQRNGRKTLTTVQGLPEEFDLKKILKAFKKEFACNGTVVEDPEYGEVIQLQGDQRKNIKEFLLEEGIAKKDNI 80


                ....
gi 12644074 109 KVHG 112
Cdd:cd11566  81 KVHG 84
SUI1 pfam01253
Translation initiation factor SUI1;
30-102 3.66e-22

Translation initiation factor SUI1;


Pssm-ID: 460137  Cd Length: 75  Bit Score: 82.48  E-value: 3.66e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12644074    30 YIHIRIQQRNGRKTLTTVQGI-ADDYDKKKLVKAFKKKFACNGTVIEHPeYGEVIQLQGDQRKNICQFLLEVGI 102
Cdd:pfam01253   3 KIHIRVEQRGGRKTVTTVSGLePFGIDLKKLAKELKKKFACGGTVVKDG-GGEEIQVQGDQRDKVAELLTEKGI 75
eIF1_SUI1_like cd00474
Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic ...
 31-104 4.26e-13

Eukaryotic initiation factor 1 and related proteins; Members of the eIF1/SUI1 (eukaryotic initiation factor 1) family are found in eukaryotes, archaea, and some bacteria; eukaryotic members are understood to play an important role in accurate initiator codon recognition during translation initiation. eIF1 interacts with 18S rRNA in the 40S ribosomal subunit during eukaryotic translation initiation. Point mutations in the yeast eIF1 implicate the protein in maintaining accurate start-site selection but its mechanism of action is unknown. The function of non-eukaryotic family members is also unclear.


Pssm-ID: 211317  Cd Length: 78  Bit Score: 59.36  E-value: 4.26e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 12644074  31 IHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPeygEVIQLQGDQRKNICQFLLEVGIVK 104
Cdd:cd00474   2 IHIKVEQRSGGKKVTKVEGLPAYIDLRKLADELKKKLGCGGSVEGEK---MEIEIQGDHTDQIIVALEEKGIDK 72
DENR_C cd11607
C-terminal domain of DENR and related proteins; DENR (density regulated protein), together ...
 31-110 2.20e-06

C-terminal domain of DENR and related proteins; DENR (density regulated protein), together with MCT-1 (multiple copies T cell malignancies), has been shown to have similar function as eIF2D translation initiation factor (also known as ligatin), which is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211320  Cd Length: 86  Bit Score: 42.16  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074  31 IHIRIQQRNGRKTLTTVQGI-ADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLLE-VGIVKEEQL 108
Cdd:cd11607   3 VTIKRISRNKRKFVTTVTGLeTFGIDLKKAAKLFAKKFACGASVTKGAEGKDEIVIQGDVTDDIVDLILEkWPEIDEDNI 82


                ..
gi 12644074 109 KV 110
Cdd:cd11607  83 EI 84
eIF2D_C cd11608
C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also ...
 31-104 3.26e-05

C-terminal domain of eIF2D and related proteins; eIF2D translation initiation factor (also known as ligatin) is involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner.


Pssm-ID: 211321  Cd Length: 85  Bit Score: 39.08  E-value: 3.26e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12644074  31 IHIRIQQRNGRKTLTTVQGIaDDY--DKKKLVKAFKKKFACNGTV--IEHPEYGEVIQLQGDQRKNICQFLLEVGIVK 104
Cdd:cd11608   2 IDITTERRQGNKKVTLISGL-ESFgiDPEEFAKELQKKCAASTSVspLPGKKKGVEVQVQGNQVKFVAKLLTEKYGVP 78
PRK00939 PRK00939
stress response translation initiation inhibitor YciH;
31-109 2.32e-04

stress response translation initiation inhibitor YciH;


Pssm-ID: 179173  Cd Length: 99  Bit Score: 37.21  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12644074   31 IHIRIQQRNGRKTLTTVQGI-ADDYDKKKLVKAFKKKFACNGTViehpeYGEVIQLQGDQRKNICQFLLEVGIvKEEQLK 109
Cdd:PRK00939  26 IKIKVDKRRYGKEVTIIEGIdPKDIDLKELAKKLKSKLACGGTV-----KDGRIELQGDHRERVKELLIKMGF-SEENIE 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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