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Conserved domains on  [gi|1036011976|gb|OAY90119|]
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3-phosphoshikimate 1-carboxyvinyltransferase [Bacillus subtilis subsp. subtilis]

Protein Classification

3-phosphoshikimate 1-carboxyvinyltransferase( domain architecture ID 11479797)

3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate

EC:  2.5.1.19
Gene Ontology:  GO:0009073|GO:0008652|GO:0003866|GO:0009423
PubMed:  17348837

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-427 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


:

Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 560.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   1 MKREKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSgsDVVIHGKGIDALKE 80
Cdd:PRK02427    5 LLIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIEDD--EVVVEGVGGGGLKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  81 PESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGeFTPLSVSGA-SLKGIDYV 159
Cdd:PRK02427   83 PEDVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEG-YLPLTIRGGkKGGPIEYD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 160 SPVASAQIKSAVLLAGLQAEG--TTTVTEPHKSRDHTE---RMLSAFGVKLSEDQT----SVSIAGGQKLTAADIFVPGD 230
Cdd:PRK02427  162 GPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEGwgyrRIVIKGGQRLRGQDITVPGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 231 ISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTG--IIDVLQNMGAKLEIKPSADSGaEPYGDLIIETSSLKAVEIGgdiIP 308
Cdd:PRK02427  242 PSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREGG-EPVGDIRVRSSELKGIDID---IP 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 309 RLIDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKqtlKGGAAVSSHGDHRIG 388
Cdd:PRK02427  318 DIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGG---PLAGVVDSYGDHRIA 394

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1036011976 389 MMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKK 427
Cdd:PRK02427  395 MAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGAN 433
 
Name Accession Description Interval E-value
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-427 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 560.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   1 MKREKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSgsDVVIHGKGIDALKE 80
Cdd:PRK02427    5 LLIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIEDD--EVVVEGVGGGGLKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  81 PESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGeFTPLSVSGA-SLKGIDYV 159
Cdd:PRK02427   83 PEDVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEG-YLPLTIRGGkKGGPIEYD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 160 SPVASAQIKSAVLLAGLQAEG--TTTVTEPHKSRDHTE---RMLSAFGVKLSEDQT----SVSIAGGQKLTAADIFVPGD 230
Cdd:PRK02427  162 GPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEGwgyrRIVIKGGQRLRGQDITVPGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 231 ISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTG--IIDVLQNMGAKLEIKPSADSGaEPYGDLIIETSSLKAVEIGgdiIP 308
Cdd:PRK02427  242 PSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREGG-EPVGDIRVRSSELKGIDID---IP 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 309 RLIDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKqtlKGGAAVSSHGDHRIG 388
Cdd:PRK02427  318 DIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGG---PLAGVVDSYGDHRIA 394

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1036011976 389 MMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKK 427
Cdd:PRK02427  395 MAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGAN 433
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-424 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 547.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   1 MKREKVQ---TLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQ-SGSDVVIHGKGiD 76
Cdd:COG0128     1 MSSLTIAppsPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEElDGGTLRVTGVG-G 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  77 ALKEPESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGeFTPLSVSGASLKGI 156
Cdd:COG0128    80 GLKEPDAVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGG-YLPLTIRGGPLKGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 157 DYVSP-VASAQIKSAVLLAGLQAEG--TTTVT---EPHKSRDHTERMLSAFGVKLS-EDQTSVSIAGGQKLTAADIFVPG 229
Cdd:COG0128   159 EYEIPgSASSQFKSALLLAGPLAEGglEITVTgelESKPYRDHTERMLRAFGVEVEvEGYRRFTVPGGQRYRPGDYTVPG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 230 DISSAAFFLAAGAMVpNSRIVLKNVGLNPT--RTGIIDVLQNMGAKLEIKPsadsgaepyGDLIIETSSLKAVEIGGDII 307
Cdd:COG0128   239 DISSAAFFLAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIEN---------DGITVRGSPLKGIDIDLSDI 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 308 PrliDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKgGAAVSSHGDHRI 387
Cdd:COG0128   309 P---DEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLK-GAEVDSYGDHRI 384

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1036011976 388 GMMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKL 424
Cdd:COG0128   385 AMAFAVAGLRAEGPVTIDDAECVAKSFPDFFELLESL 421
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 9-424 0e+00

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 512.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   9 LHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGIdALKEPESLLDVG 88
Cdd:cd01556     1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVEIVGGGG-LGLPPEAVLDCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  89 NSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGAsLKGIDYVSPVA-SAQI 167
Cdd:cd01556    80 NSGTTMRLLTGLLALQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPLIGGGG-LKGGEVEIPGAvSSQF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 168 KSAVLLAGLQAEGTTTVT----EPHKSRDHTERMLSAFGVKLS-EDQTSVSIAGGQKLTAADIFVPGDISSAAFFLAAGA 242
Cdd:cd01556   159 KSALLLAAPLAEGPTTIIigelESKPYIDHTERMLRAFGAEVEvDGYRTITVKGGQKYKGPEYTVEGDASSAAFFLAAAA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 243 MVPnSRIVLKNVGLNPTRTGIIDVLQNMGAKLEIKPSADSGAEPygdliieTSSLKAVEIGGDIIPrliDEIPIIALLAT 322
Cdd:cd01556   239 ITG-SEIVIKNVGLNSGDTGIIDVLKEMGADIEIGNEDTVVVES-------GGKLKGIDIDGNDIP---DEAPTLAVLAA 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 323 QAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLGIASCITEEPI 402
Cdd:cd01556   308 FAEGPTRIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPLKGAGVEVYTYGDHRIAMSFAIAGLVAEGGV 387

                         410       420
                  ....*....|....*....|..
gi 1036011976 403 EIEHTDAIHVSYPTFFEHLNKL 424
Cdd:cd01556   388 TIEDPECVAKSFPNFFEDLESL 409
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 11-427 4.20e-152

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 437.09  E-value: 4.20e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  11 GEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGidaLKEPESLLDVGNS 90
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAVIEGVG---GKEPQAELDLGNS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  91 GTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVSPVASAQIKSA 170
Cdd:TIGR01356  78 GTTARLLTGVLALADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYKSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 171 VLLAG--LQAEGTTTVTEPHKSRDHTERML---SAFGVKLS-EDQTSVSIAGGQKLTAADIFVPGDISSAAFFLAAGAMV 244
Cdd:TIGR01356 158 LLLAApaLQAVGITIVGEPLKSRPYIEITLdllGSFGVEVErSDGRKIVVPGGQKYGPQGYDVPGDYSSAAFFLAAAAIT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 245 PNsRIVLKNVGLNPTRTG--IIDVLQNMGAKLEIKPsadsgaepyGDLIIET-SSLKAVEIGgdiIPRLIDEIPIIALLA 321
Cdd:TIGR01356 238 GG-RVTLENLGINPTQGDkaIIIVLEEMGADIEVEE---------DDLIVEGaSGLKGIKID---MDDMIDELPTLAVLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 322 TQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKgGAAVSSHGDHRIGMMLGIASCITEEP 401
Cdd:TIGR01356 305 AFAEGVTRITGAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELK-GAVVDTFGDHRIAMAFAVAGLVAEGE 383

                         410       420
                  ....*....|....*....|....*.
gi 1036011976 402 IEIEHTDAIHVSYPTFFEHLNKLSKK 427
Cdd:TIGR01356 384 VLIDDPECVAKSFPSFFDVLERLGAN 409
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
4-421 2.58e-131

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 384.34  E-value: 2.58e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   4 EKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHI---EQSGSDVVIHGKGIDALKE 80
Cdd:pfam00275   1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIiklDDEKSVVIVEGLGGSFEAP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  81 PESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS 160
Cdd:pfam00275  81 EDLVLDMGNSGTALRPLTGRLALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGLRLGGIHIDG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 161 PVASAQIKSAVLLAGLQAEGTTTVTEPHK--SRDHTERMLSAFGVKLSEDQT--SVSIAGGQKLTAADIFVPGDISSAAF 236
Cdd:pfam00275 161 DVSSQFVTSLLMLAALLAEGTTTIENLASepYIDDTENMLKKFGAKIEGSGTelSITVKGGEKLPGQEYRVEGDRSSAAY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 237 FLAAGAMVPnSRIVLKNVGLNPTRTG--IIDVLQNMGAKLEikpsadsgAEPYGDLIIETSSLKAVEIggdIIPRLIDEI 314
Cdd:pfam00275 241 FLVAAAITG-GTVTVENVGINSLQGDeaLLEILEKMGAEIT--------QEEDADIVVGPPGLRGKAV---DIRTAPDPA 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 315 PIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLGIA 394
Cdd:pfam00275 309 PTTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIPAVKELKGAEVDSYGDHRIAMALALA 388

                         410       420
                  ....*....|....*....|....*..
gi 1036011976 395 SCITEEPIEIEHTDAIHVSYPTFFEHL 421
Cdd:pfam00275 389 GLVAEGETIIDDIECTDRSFPDFEEKL 415
 
Name Accession Description Interval E-value
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-427 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 560.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   1 MKREKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSgsDVVIHGKGIDALKE 80
Cdd:PRK02427    5 LLIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIEDD--EVVVEGVGGGGLKE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  81 PESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGeFTPLSVSGA-SLKGIDYV 159
Cdd:PRK02427   83 PEDVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEG-YLPLTIRGGkKGGPIEYD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 160 SPVASAQIKSAVLLAGLQAEG--TTTVTEPHKSRDHTE---RMLSAFGVKLSEDQT----SVSIAGGQKLTAADIFVPGD 230
Cdd:PRK02427  162 GPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEGwgyrRIVIKGGQRLRGQDITVPGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 231 ISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTG--IIDVLQNMGAKLEIKPSADSGaEPYGDLIIETSSLKAVEIGgdiIP 308
Cdd:PRK02427  242 PSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREGG-EPVGDIRVRSSELKGIDID---IP 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 309 RLIDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKqtlKGGAAVSSHGDHRIG 388
Cdd:PRK02427  318 DIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGG---PLAGVVDSYGDHRIA 394

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1036011976 389 MMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKK 427
Cdd:PRK02427  395 MAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGAN 433
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-424 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 547.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   1 MKREKVQ---TLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQ-SGSDVVIHGKGiD 76
Cdd:COG0128     1 MSSLTIAppsPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEElDGGTLRVTGVG-G 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  77 ALKEPESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGeFTPLSVSGASLKGI 156
Cdd:COG0128    80 GLKEPDAVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGG-YLPLTIRGGPLKGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 157 DYVSP-VASAQIKSAVLLAGLQAEG--TTTVT---EPHKSRDHTERMLSAFGVKLS-EDQTSVSIAGGQKLTAADIFVPG 229
Cdd:COG0128   159 EYEIPgSASSQFKSALLLAGPLAEGglEITVTgelESKPYRDHTERMLRAFGVEVEvEGYRRFTVPGGQRYRPGDYTVPG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 230 DISSAAFFLAAGAMVpNSRIVLKNVGLNPT--RTGIIDVLQNMGAKLEIKPsadsgaepyGDLIIETSSLKAVEIGGDII 307
Cdd:COG0128   239 DISSAAFFLAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIEN---------DGITVRGSPLKGIDIDLSDI 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 308 PrliDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKgGAAVSSHGDHRI 387
Cdd:COG0128   309 P---DEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLK-GAEVDSYGDHRI 384

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1036011976 388 GMMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKL 424
Cdd:COG0128   385 AMAFAVAGLRAEGPVTIDDAECVAKSFPDFFELLESL 421
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 9-424 0e+00

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 512.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   9 LHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGIdALKEPESLLDVG 88
Cdd:cd01556     1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVEIVGGGG-LGLPPEAVLDCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  89 NSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGAsLKGIDYVSPVA-SAQI 167
Cdd:cd01556    80 NSGTTMRLLTGLLALQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPLIGGGG-LKGGEVEIPGAvSSQF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 168 KSAVLLAGLQAEGTTTVT----EPHKSRDHTERMLSAFGVKLS-EDQTSVSIAGGQKLTAADIFVPGDISSAAFFLAAGA 242
Cdd:cd01556   159 KSALLLAAPLAEGPTTIIigelESKPYIDHTERMLRAFGAEVEvDGYRTITVKGGQKYKGPEYTVEGDASSAAFFLAAAA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 243 MVPnSRIVLKNVGLNPTRTGIIDVLQNMGAKLEIKPSADSGAEPygdliieTSSLKAVEIGGDIIPrliDEIPIIALLAT 322
Cdd:cd01556   239 ITG-SEIVIKNVGLNSGDTGIIDVLKEMGADIEIGNEDTVVVES-------GGKLKGIDIDGNDIP---DEAPTLAVLAA 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 323 QAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLGIASCITEEPI 402
Cdd:cd01556   308 FAEGPTRIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPLKGAGVEVYTYGDHRIAMSFAIAGLVAEGGV 387

                         410       420
                  ....*....|....*....|..
gi 1036011976 403 EIEHTDAIHVSYPTFFEHLNKL 424
Cdd:cd01556   388 TIEDPECVAKSFPNFFEDLESL 409
PRK14806 PRK14806
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ...
 8-419 1.68e-153

bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 237820 [Multi-domain]  Cd Length: 735  Bit Score: 452.14  E-value: 1.68e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   8 TLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSD-VVIHGKGIDALKEPESLLD 86
Cdd:PRK14806  311 AVKGTIRVPGDKSISHRSIMLGSLAEGVTEVEGFLEGEDALATLQAFRDMGVVIEGPHNGrVTIHGVGLHGLKAPPGPLY 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  87 VGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKI----DGRAggeftPLSVSGAS-LKGIDYVSP 161
Cdd:PRK14806  391 MGNSGTSMRLLSGLLAAQSFDSVLTGDASLSKRPMERVAKPLREMGAVIetgeEGRP-----PLSIRGGQrLKGIHYDLP 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 162 VASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQKLTAADIFVPGDISSAAFFLAAG 241
Cdd:PRK14806  466 MASAQVKSCLLLAGLYAEGETSVTEPAPTRDHTERMLRGFGYPVKVEGNTISVEGGGKLTATDIEVPADISSAAFFLVAA 545

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 242 AMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEIKPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLA 321
Cdd:PRK14806  546 SIAEGSELTLEHVGINPTRTGVIDILKLMGADITLENEREVGGEPVADIRVRGARLKGIDIPEDQVPLAIDEFPVLFVAA 625

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 322 TQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTlkGGAAVSSHGDHRIGMMLGIASCITEEP 401
Cdd:PRK14806  626 ACAEGRTVLTGAEELRVKESDRIQVMADGLKTLGIDCEPTPDGIIIEGGIF--GGGEVESHGDHRIAMSFSVASLRASGP 703

                         410
                  ....*....|....*...
gi 1036011976 402 IEIEHTDAIHVSYPTFFE 419
Cdd:PRK14806  704 ITIHDCANVATSFPNFLE 721
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 11-427 4.20e-152

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 437.09  E-value: 4.20e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  11 GEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGidaLKEPESLLDVGNS 90
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAVIEGVG---GKEPQAELDLGNS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  91 GTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVSPVASAQIKSA 170
Cdd:TIGR01356  78 GTTARLLTGVLALADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYKSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 171 VLLAG--LQAEGTTTVTEPHKSRDHTERML---SAFGVKLS-EDQTSVSIAGGQKLTAADIFVPGDISSAAFFLAAGAMV 244
Cdd:TIGR01356 158 LLLAApaLQAVGITIVGEPLKSRPYIEITLdllGSFGVEVErSDGRKIVVPGGQKYGPQGYDVPGDYSSAAFFLAAAAIT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 245 PNsRIVLKNVGLNPTRTG--IIDVLQNMGAKLEIKPsadsgaepyGDLIIET-SSLKAVEIGgdiIPRLIDEIPIIALLA 321
Cdd:TIGR01356 238 GG-RVTLENLGINPTQGDkaIIIVLEEMGADIEVEE---------DDLIVEGaSGLKGIKID---MDDMIDELPTLAVLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 322 TQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKgGAAVSSHGDHRIGMMLGIASCITEEP 401
Cdd:TIGR01356 305 AFAEGVTRITGAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELK-GAVVDTFGDHRIAMAFAVAGLVAEGE 383

                         410       420
                  ....*....|....*....|....*.
gi 1036011976 402 IEIEHTDAIHVSYPTFFEHLNKLSKK 427
Cdd:TIGR01356 384 VLIDDPECVAKSFPSFFDVLERLGAN 409
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
4-421 2.58e-131

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 384.34  E-value: 2.58e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   4 EKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHI---EQSGSDVVIHGKGIDALKE 80
Cdd:pfam00275   1 TGGSRLSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIiklDDEKSVVIVEGLGGSFEAP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  81 PESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS 160
Cdd:pfam00275  81 EDLVLDMGNSGTALRPLTGRLALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGLRLGGIHIDG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 161 PVASAQIKSAVLLAGLQAEGTTTVTEPHK--SRDHTERMLSAFGVKLSEDQT--SVSIAGGQKLTAADIFVPGDISSAAF 236
Cdd:pfam00275 161 DVSSQFVTSLLMLAALLAEGTTTIENLASepYIDDTENMLKKFGAKIEGSGTelSITVKGGEKLPGQEYRVEGDRSSAAY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 237 FLAAGAMVPnSRIVLKNVGLNPTRTG--IIDVLQNMGAKLEikpsadsgAEPYGDLIIETSSLKAVEIggdIIPRLIDEI 314
Cdd:pfam00275 241 FLVAAAITG-GTVTVENVGINSLQGDeaLLEILEKMGAEIT--------QEEDADIVVGPPGLRGKAV---DIRTAPDPA 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 315 PIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLGIA 394
Cdd:pfam00275 309 PTTAVLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIPAVKELKGAEVDSYGDHRIAMALALA 388

                         410       420
                  ....*....|....*....|....*..
gi 1036011976 395 SCITEEPIEIEHTDAIHVSYPTFFEHL 421
Cdd:pfam00275 389 GLVAEGETIIDDIECTDRSFPDFEEKL 415
EPT-like cd01554
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ...
 9-424 9.07e-125

Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.


Pssm-ID: 238795  Cd Length: 408  Bit Score: 367.31  E-value: 9.07e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   9 LHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGIDALKEPESLLDVG 88
Cdd:cd01554     1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  89 NSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVSPVASAQIK 168
Cdd:cd01554    81 NSGTAIRLISGVLAGADFEVELFGDDSLSKRPMDRVTLPLKKMGASISGQEERDLPPLLKGGKNLGPIHYEDPIASAQVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 169 SAVLLAGLQAEGTTTVTEPHK--SRDHTERMLSAFGVKLSEDQTS-VSIAGGQKLTAADIFVPGDISSAAFFLAAGAMVP 245
Cdd:cd01554   161 SALMFAALLAKGETVIIEAAKepTINHTENMLQTFGGHISVQGTKkIVVQGPQKLTGQKYVVPGDISSAAFFLVAAAIAP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 246 nSRIVLKNVGLNPTRTGIIDVLQNMGAKLEIkpsadsgAEPYgdLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAE 325
Cdd:cd01554   241 -GRLVLQNVGINETRTGIIDVLRAMGAKIEI-------GEDT--ISVESSDLKATEICGALIPRLIDELPIIALLALQAQ 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 326 GTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKgGAAVSSHGDHRIGMMLGIASCITEEPIEIE 405
Cdd:cd01554   311 GTTVIKDAEELKVKETDRIFVVADELNSMGADIEPTADGMIIKGKEKLH-GARVNTFGDHRIGMMTALAALVADGEVELD 389

                         410
                  ....*....|....*....
gi 1036011976 406 HTDAIHVSYPTFFEHLNKL 424
Cdd:cd01554   390 RAEAINTSYPSFFDDLESL 408
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
11-426 3.13e-50

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 179.86  E-value: 3.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  11 GEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGiDALKEPESLLDVGNS 90
Cdd:PRK11860   17 GTVRLPGSKSISNRVLLLAALSEGTTTVRDLLDSDDTRVMLDALRALGCGVEQLGDTYRITGLG-GQFPVKQADLFLGNA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  91 GTTIRLM---LGILAGRPFYSAVAgdeSIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDyvsPVA---- 163
Cdd:PRK11860   96 GTAMRPLtaaLALLGGEYELSGVP---RMHERPIGDLVDALRQLGCDIDYLGNEGFPPLRIGPAPLRLDA---PIRvrgd 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 164 -SAQIKSAVLLAGLQAEGTTTVTEPHK---SRDHTE---RMLSAFGVKLSED--QTSVSIAGGQKLTAADIFVPGDISSA 234
Cdd:PRK11860  170 vSSQFLTALLMALPLVARRDITIEVVGeliSKPYIEitlNLLARFGIAVQREgwQRFTIPAGSRYRSPGEIHVEGDASSA 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 235 AFFLAAGAMVPNSRIVLKNVGLNPTRTGI--IDVLQNMGAKLEIKPS---ADSGAEPygdliietssLKAVEIGGDIIPr 309
Cdd:PRK11860  250 SYFIAAGAIAGGAPVRIEGVGRDSIQGDIrfAEAARAMGAQVTSGPNwleVRRGAWP----------LKAIDLDCNHIP- 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 310 liDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKG--GAAVSSHGDHRI 387
Cdd:PRK11860  319 --DAAMTLAVMALYADGTTTLRNIASWRVKETDRIAAMATELRKLGATVEEGADYIRVTPPAQAADwkAAAIHTYDDHRM 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1036011976 388 GMMLGIASC-ITEEPIEIEHTDAIHVSYPTFFEHLNKLSK 426
Cdd:PRK11860  397 AMCFSLAAFnPAGLPVRINDPKCVAKTFPDYFEALFSVAQ 436
PLN02338 PLN02338
3-phosphoshikimate 1-carboxyvinyltransferase
 6-426 6.67e-46

3-phosphoshikimate 1-carboxyvinyltransferase


Pssm-ID: 177972 [Multi-domain]  Cd Length: 443  Bit Score: 164.15  E-value: 6.67e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   6 VQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSD--VVIHGKG----IDALK 79
Cdd:PLN02338    9 IKEISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLDSDDIRYMLGALKTLGLNVEEDSENnrAVVEGCGgkfpVSGDS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  80 EPESLLDVGNSGTtirlmlgilAGRPFYSAVA-----------GDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSV 148
Cdd:PLN02338   89 KEDVELFLGNAGT---------AMRPLTAAVTaaggnasyvldGVPRMRERPIGDLVDGLKQLGADVECTLGTNCPPVRV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 149 SGAS-LKGID-YVSPVASAQIKSAVLLAGLQAEGTTT-------VTEPHKsrDHTERMLSAFGVKL--SEDQTSVSIAGG 217
Cdd:PLN02338  160 NAAGgLPGGKvKLSGSISSQYLTALLMAAPLALGDVEieivdklISVPYV--EMTLKLMERFGVSVehSDSWDRFFIKGG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 218 QKLTA-ADIFVPGDISSAAFFLAaGAMVPNSRIVLKNVGLNPTR--TGIIDVLQNMGAKLEIKPSADSGAEPYGDLIIET 294
Cdd:PLN02338  238 QKYKSpGNAYVEGDASSASYFLA-GAAITGGTVTVEGCGTTSLQgdVKFAEVLEKMGAKVEWTENSVTVTGPPRDAFGGK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 295 SsLKAVEIGGDIIPrliDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLK 374
Cdd:PLN02338  317 H-LKAIDVNMNKMP---DVAMTLAVVALFADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCIITPPKKLK 392

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1036011976 375 gGAAVSSHGDHRIGMMLGIASCiTEEPIEIEHTDAIHVSYPTFFEHLNKLSK 426
Cdd:PLN02338  393 -PAEIDTYDDHRMAMAFSLAAC-GDVPVTINDPGCTRKTFPTYFDVLESIAK 442
PRK11861 PRK11861
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 11-425 5.85e-38

bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 183343 [Multi-domain]  Cd Length: 673  Bit Score: 146.00  E-value: 5.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  11 GEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSGSDVVIHGKGiDALKEPESLLDVGNS 90
Cdd:PRK11861  253 GTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGGTCVVGGTR-GAFTAKTADLFLGNA 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  91 GTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASlkgIDYVSPV-----ASA 165
Cdd:PRK11861  332 GTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPAT---ISVDAPIrvrgdVSS 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 166 QIKSAVL--LAGLQAEGTTTVTEPHK---SRDHTE---RMLSAFGVKLSED--QTSVSIAGGQKLTAADIFVPGDISSAA 235
Cdd:PRK11861  409 QFLTALLmtLPLVKAKDGASVVEIDGeliSKPYIEitiKLMARFGVTVERDgwQRFTVPAGVRYRSPGTIMVEGDASSAS 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 236 FFLAAGAMvPNSRIVLKNVGLNPTR--TGIIDVLQNMGAKLEIkpsADSGAEPYGdLIIETSSLKAVEIGGDIIPrliDE 313
Cdd:PRK11861  489 YFLAAGAL-GGGPLRVEGVGRASIQgdVGFANALMQMGANVTM---GDDWIEVRG-IGHDHGRLAPIDMDFNLIP---DA 560

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 314 IPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLGI 393
Cdd:PRK11861  561 AMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTPNASIDTYDDHRMAMCFSL 640

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1036011976 394 AScITEEPIEIEHTDAIHVSYPTFFEHLNKLS 425
Cdd:PRK11861  641 VS-LGGVPVRINDPKCVGKTFPDYFDRFLALA 671
UdpNAET cd01555
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ...
 9-424 1.79e-20

UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.


Pssm-ID: 238796  Cd Length: 400  Bit Score: 92.54  E-value: 1.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   9 LHGEIHIPGDKSishrSV---MFGA-LAAGTTTVKNfLPG-ADCLSTIDCFRKMGVHIEQSGSD-VVIHGKGIDALKEPE 82
Cdd:cd01555     1 LSGEVRISGAKN----AAlpiLAAAlLTDEPVTLRN-VPDlLDVETMIELLRSLGAKVEFEGENtLVIDASNINSTEAPY 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  83 SLLDvgnsgtTIR---LMLGILAGRpFYSAV---AGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFtpLSVSGaSLKG- 155
Cdd:cd01555    76 ELVR------KMRasiLVLGPLLAR-FGEARvslPGGCAIGARPVDLHLKGLEALGAKIEIEDGYVE--AKAAG-RLKGa 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 156 ---IDYVSPVASAQIksavLLAGLQAEGTTTVT----EPHKSRdhTERMLSAFGVKLSEDQTSV-SIAGGQKLTAADIFV 227
Cdd:cd01555   146 riyLDFPSVGATENI----MMAAVLAEGTTVIEnaarEPEIVD--LANFLNKMGAKIEGAGTDTiRIEGVERLHGAEHTV 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 228 PGDISSAAFFLAAGAMVpNSRIVLKNVGLNPTRTgIIDVLQNMGAKLEIKpsadsgaepyGDLII---ETSSLKAVEIGG 304
Cdd:cd01555   220 IPDRIEAGTFLVAAAIT-GGDITVENVIPEHLEA-VLAKLREMGAKIEIG----------EDGIRvdgDGGRLKAVDIET 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 305 DIIPRLI-DEIPIIALLATQAEGTTVIKDaaelKVKEtNRIdTVVSELRKLGAEIEPTADGMKVYGKQTLKgGAAVSSHg 383
Cdd:cd01555   288 APYPGFPtDLQAQFMALLTQAEGTSVITE----TIFE-NRF-MHVDELNRMGADIKVEGNTAIIRGVTKLS-GAPVMAT- 359

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1036011976 384 DHRIGMMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKL 424
Cdd:cd01555   360 DLRAGAALVLAGLAAEGETIISNIYHIDRGYERIEEKLRAL 400
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 9-399 2.88e-16

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 80.07  E-value: 2.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   9 LHGEIHIPGDKSishrSV---MFGA-LAAGTTTVKNfLPG-ADCLSTIDCFRKMGVHIEQSGSDVV-IHGKGIDALKEPE 82
Cdd:PRK09369   12 LSGEVTISGAKN----AAlpiLAASlLAEEPVTLTN-VPDlSDVRTMIELLRSLGAKVEFDGNGTVtIDASNINNTEAPY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  83 SLldVGnsgtTIR---LMLG-ILA--GRPFYSAVAGDeSIAKRPMKRVTEPLKKMGAKIDGRAGgeFTPLSVSGaSLKG- 155
Cdd:PRK09369   87 EL--VK----KMRasiLVLGpLLArfGEAKVSLPGGC-AIGARPVDLHLKGLEALGAEIEIEHG--YVEAKADG-RLKGa 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 156 ---IDYVSPVASAQIksavLLAGLQAEGTTTVT----EPhksrdhtE-----RMLSAFGVKLSEDQTSV-SIAGGQKLTA 222
Cdd:PRK09369  157 hivLDFPSVGATENI----LMAAVLAEGTTVIEnaarEP-------EivdlaNFLNKMGAKISGAGTDTiTIEGVERLHG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 223 ADIFVPGDISSAAFFLAAGAMVpNSRIVLKNVGLNPTRTgIIDVLQNMGAKLEIKPSadsgaepyGDLIIETSSLKAVEI 302
Cdd:PRK09369  226 AEHTVIPDRIEAGTFLVAAAIT-GGDVTIRGARPEHLEA-VLAKLREAGAEIEEGED--------GIRVDMPGRLKAVDI 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 303 GGDIIPRLI-DEIPIIALLATQAEGTTVIKDaaelKVKEtNRIdTVVSELRKLGAEIEP---TAdgmKVYGKQTLKgGAA 378
Cdd:PRK09369  296 KTAPYPGFPtDMQAQFMALLTQAEGTSVITE----TIFE-NRF-MHVPELIRMGADIEVdghTA---VVRGVEKLS-GAP 365

                         410       420
                  ....*....|....*....|.
gi 1036011976 379 VSShGDHRIGMMLGIASCITE 399
Cdd:PRK09369  366 VMA-TDLRASASLVLAGLVAE 385
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 9-424 4.75e-16

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 79.64  E-value: 4.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976   9 LHGEIHIPGDKSishrSV---MFGA-LAAGTTTVKNfLPG-ADCLSTIDCFRKMGVHIE-QSGSDVVIHGKGIDALKEPE 82
Cdd:COG0766    12 LSGEVRISGAKN----AAlpiLAAAlLTDGPVTLRN-VPDlSDVRTMLELLESLGVKVErDDGGTLTIDASNINSTEAPY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976  83 SLldvgnsGTTIR---LMLGILAGRpFYSA-VA---GDeSIAKRPMKRVTEPLKKMGAKIDGRAGGeftpLSVSGASLKG 155
Cdd:COG0766    87 EL------VRKMRasiLVLGPLLAR-FGEArVSlpgGC-AIGARPIDLHLKGLEALGAEIEIEHGY----IEARAGRLKG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 156 IDYVSPVAS----AQIksavLLAGLQAEGTTTVT----EPhksrdhtE-----RMLSAFGVKLSEDQTSV-SIAGGQKLT 221
Cdd:COG0766   155 ARIYLDFPSvgatENI----MMAAVLAEGTTVIEnaarEP-------EivdlaNFLNAMGAKIEGAGTDTiTIEGVEKLH 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 222 AADIFVPGDISSAAFFLAAGAMVpNSRIVLKNVGLNPTRTgIIDVLQNMGAKLEIkpsadsgaEPYGDLIIETSSLKAVE 301
Cdd:COG0766   224 GAEHTVIPDRIEAGTFLVAAAIT-GGDVTVKNVIPEHLEA-VLAKLREAGVEIEE--------GDDGIRVRGPGRLKAVD 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 302 I------GgdiIPrlIDEIPIIALLATQAEGTTVIKDaaelKVKEtNRIdTVVSELRKLGAEIEptADG--MKVYGKQTL 373
Cdd:COG0766   294 IktapypG---FP--TDLQAQFMALLTQAEGTSVITE----TVFE-NRF-MHVDELNRMGADIK--LDGhtAIVRGVTKL 360

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1036011976 374 KgGAAVSSHgDHRIGMMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKL 424
Cdd:COG0766   361 S-GAPVMAT-DLRAGAALVLAGLAAEGETVIDNIYHIDRGYENLEEKLRAL 409
EPT_RTPC-like cd01553
This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate ...
 229-424 3.58e-03

This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a 4th slightly different domain inserted between the 2nd and 3rd repeat. They evidently share the same active site location, although the catalytic residues differ.


Pssm-ID: 238794  Cd Length: 211  Bit Score: 38.80  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 229 GDISSAAFFLAAgAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEIKPSAD-SGAEPYGDLIIET-SSLKAVEIGGDI 306
Cdd:cd01553     8 GGGQILRSFLVL-AAISGGPITVTGIRPDRAKPGLLRQHLTFLKALEKICGATvEGGELGSDRISFRpGTVRGGDVRFAI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036011976 307 IPR--LIDEIPIIALLATQAEGTTVIKDAAELKVKETNRID----TVVSELRKLGAEIEPTADGMKVYGkqTLKGGAAVS 380
Cdd:cd01553    87 GSAgsCTDVLQTILPLLLFAKGPTRLTVTGGTDNPSAPPADfirfVLEPELAKIGAHQEETLLRHGFYP--AGGGVVATE 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1036011976 381 SHGDHRIG------MMLGIASCITEEPIEIEHTDAIhvsYPTFFEHLNKL 424
Cdd:cd01553   165 VSPVEKLNtaqlrqLVLPMLLASGAVEFTVAHPSCH---LLTNFAVLEAL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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