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Conserved domains on  [gi|1036291995|gb|OAZ51008|]
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glycosyl transferase [Paenibacillus polymyxa]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135931)

glycosyltransferase family 2 protein transfers sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-223 1.11e-78

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


:

Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 238.30  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVL-YPESNEGVIASFFDLIQRSseT 86
Cdd:cd04196     2 VLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDPFIIILiRNGKNLGVARNFESLLQAA--D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  87 FDYYAFCDQDDVWMPNKLARAVAQLREKDEsrPLMYCSATQMVSQNLEPLKVWPAD---IPRPLSLYNALIENVCVGCTM 163
Cdd:cd04196    80 GDYVFFCDQDDIWLPDKLERLLKAFLKDDK--PLLVYSDLELVDENGNPIGESFFEyqkIKPGTSFNNLLFQNVVTGCTM 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995 164 VINKQTLQFVKTRMPdtlDNIIMHDWWIYLCTAAFGEVVFDPEPSIWYRQHQNNVLGGST 223
Cdd:cd04196   158 AFNRELLELALPFPD---ADVIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVVGANK 214
 
Name Accession Description Interval E-value
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-223 1.11e-78

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 238.30  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVL-YPESNEGVIASFFDLIQRSseT 86
Cdd:cd04196     2 VLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDPFIIILiRNGKNLGVARNFESLLQAA--D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  87 FDYYAFCDQDDVWMPNKLARAVAQLREKDEsrPLMYCSATQMVSQNLEPLKVWPAD---IPRPLSLYNALIENVCVGCTM 163
Cdd:cd04196    80 GDYVFFCDQDDIWLPDKLERLLKAFLKDDK--PLLVYSDLELVDENGNPIGESFFEyqkIKPGTSFNNLLFQNVVTGCTM 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995 164 VINKQTLQFVKTRMPdtlDNIIMHDWWIYLCTAAFGEVVFDPEPSIWYRQHQNNVLGGST 223
Cdd:cd04196   158 AFNRELLELALPFPD---ADVIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVVGANK 214
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 3-218 3.68e-26

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 102.86  E-value: 3.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   3 KPSVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDLIQR 82
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  83 SseTFDYYAFCDQDDVWMPNKLARAVAQLREKDESrpLMYCSATqmVSQNLEPLKVWPADIPRPLSLYNALIENVCVGct 162
Cdd:COG0463    81 A--RGDYIAFLDADDQLDPEKLEELVAALEEGPAD--LVYGSRL--IREGESDLRRLGSRLFNLVRLLTNLPDSTSGF-- 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1036291995 163 MVINKQTLQFVKtrmpdtLDNIIMHDWWIYLCTAAFGEVVFDPepsIWYRQHQNNV 218
Cdd:COG0463   153 RLFRREVLEELG------FDEGFLEDTELLRALRHGFRIAEVP---VRYRAGESKL 199
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 8-113 5.24e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 74.35  E-value: 5.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDLIQRSSEtf 87
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATG-- 79

                          90       100
                  ....*....|....*....|....*.
gi 1036291995  88 DYYAFCDQDDVWMPNKLARAVAQLRE 113
Cdd:pfam00535  80 DYIAFLDADDEVPPDWLEKLVEALEE 105
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-120 2.58e-07

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 51.20  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   3 KPSVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPEsNEGVIASFFDLIQR 82
Cdd:PRK10073    5 TPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQA-NAGVSVARNTGLAV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036291995  83 SseTFDYYAFCDQDDVWMPN------KLARA----VAQ------LREKDESRPL 120
Cdd:PRK10073   84 A--TGKYVAFPDADDVVYPTmyetlmTMALEddldVAQcnadwcFRDTGETWQS 135
 
Name Accession Description Interval E-value
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-223 1.11e-78

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 238.30  E-value: 1.11e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVL-YPESNEGVIASFFDLIQRSseT 86
Cdd:cd04196     2 VLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYIDKDPFIIILiRNGKNLGVARNFESLLQAA--D 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  87 FDYYAFCDQDDVWMPNKLARAVAQLREKDEsrPLMYCSATQMVSQNLEPLKVWPAD---IPRPLSLYNALIENVCVGCTM 163
Cdd:cd04196    80 GDYVFFCDQDDIWLPDKLERLLKAFLKDDK--PLLVYSDLELVDENGNPIGESFFEyqkIKPGTSFNNLLFQNVVTGCTM 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995 164 VINKQTLQFVKTRMPdtlDNIIMHDWWIYLCTAAFGEVVFDPEPSIWYRQHQNNVLGGST 223
Cdd:cd04196   158 AFNRELLELALPFPD---ADVIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVVGANK 214
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 3-218 3.68e-26

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 102.86  E-value: 3.68e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   3 KPSVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDLIQR 82
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  83 SseTFDYYAFCDQDDVWMPNKLARAVAQLREKDESrpLMYCSATqmVSQNLEPLKVWPADIPRPLSLYNALIENVCVGct 162
Cdd:COG0463    81 A--RGDYIAFLDADDQLDPEKLEELVAALEEGPAD--LVYGSRL--IREGESDLRRLGSRLFNLVRLLTNLPDSTSGF-- 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1036291995 163 MVINKQTLQFVKtrmpdtLDNIIMHDWWIYLCTAAFGEVVFDPepsIWYRQHQNNV 218
Cdd:COG0463   153 RLFRREVLEELG------FDEGFLEDTELLRALRHGFRIAEVP---VRYRAGESKL 199
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 8-130 5.18e-21

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 87.56  E-value: 5.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDLIQRSseTF 87
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAA--RG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1036291995  88 DYYAFCDQDDVWMPNKLARAVAQLrEKDESRPLMYCSATQMVS 130
Cdd:cd00761    79 EYILFLDADDLLLPDWLERLVAEL-LADPEADAVGGPGNLLFR 120
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
3-109 7.90e-17

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 77.34  E-value: 7.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   3 KPSVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALkqRYPQRVVLYPESNEGVIASFFDLIQR 82
Cdd:COG1216     2 RPKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAAL--AFPRVRVIRNPENLGFAAARNLGLRA 79

                          90       100
                  ....*....|....*....|....*..
gi 1036291995  83 SseTFDYYAFCDQDDVWMPNKLARAVA 109
Cdd:COG1216    80 A--GGDYLLFLDDDTVVEPDWLERLLA 104
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 8-113 5.24e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 74.35  E-value: 5.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDLIQRSSEtf 87
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATG-- 79

                          90       100
                  ....*....|....*....|....*.
gi 1036291995  88 DYYAFCDQDDVWMPNKLARAVAQLRE 113
Cdd:pfam00535  80 DYIAFLDADDEVPPDWLEKLVEALEE 105
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 2-115 7.41e-13

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 67.84  E-value: 7.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   2 EKPSVQILLSTYNGATYLDEQLESLINQK--DVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDL 79
Cdd:COG1215    27 DLPRVSVIIPAYNEEAVIEETLRSLLAQDypKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAG 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1036291995  80 IQRSseTFDYYAFCDQDDVWMPNKLARAVAQLREKD 115
Cdd:COG1215   107 LKAA--RGDIVVFLDADTVLDPDWLRRLVAAFADPG 140
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 2-115 2.02e-08

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 54.13  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   2 EKPSVQILLSTYNGATYLDEQLESLINQ---KDvNTQILIRDDGSTDDTisklNALKQRYPQR--VVLYPESNEGVIASF 76
Cdd:cd06439    27 YLPTVTIIIPAYNEEAVIEAKLENLLALdypRD-RLEIIVVSDGSTDGT----AEIAREYADKgvKLLRFPERRGKAAAL 101

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1036291995  77 FDLIQRSSEtfDYYAFCDQDDVWMPNKLARAVAQLREKD 115
Cdd:cd06439   102 NRALALATG--EIVVFTDANALLDPDALRLLVRHFADPS 138
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 4-123 5.97e-08

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 52.21  E-value: 5.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   4 PSVQILLSTYNGA-TYLDEQLESLINQKDVNTQILIRDDGSTDD-TISKLNALKQRYPQRVVLYPESNEG-VIASFFDLi 80
Cdd:cd04184     1 PLISIVMPVYNTPeKYLREAIESVRAQTYPNWELCIADDASTDPeVKRVLKKYAAQDPRIKVVFREENGGiSAATNSAL- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1036291995  81 qrSSETFDYYAFCDQDDVWMPNKLARAVAQLREKDESRpLMYC 123
Cdd:cd04184    80 --ELATGEFVALLDHDDELAPHALYEVVKALNEHPDAD-LIYS 119
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 12-116 6.78e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 51.41  E-value: 6.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  12 TYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTIsklNALKQRYPQRVVLYPESNEGVIASFFDLIQRSSetFDYYA 91
Cdd:cd04186     5 NYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSV---ELLRELFPEVRLIRNGENLGFGAGNNQGIREAK--GDYVL 79

                          90       100
                  ....*....|....*....|....*
gi 1036291995  92 FCDQDDVWMPNKLARAVAQLREKDE 116
Cdd:cd04186    80 LLNPDTVVEPGALLELLDAAEQDPD 104
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 12-214 1.19e-07

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 51.39  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  12 TYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLnalkQRYPQRVVLY---PES------NEGviasffdlIQR 82
Cdd:cd06433     6 TYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDII----KKYEDKITYWisePDKgiydamNKG--------IAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  83 SseTFDYYAFCDQDDVWMPNKLARAVAQLREKDEsrPLMYCSATQMVSQNLEPLKVWPADIPRPLSLYnalienvcvgCT 162
Cdd:cd06433    74 A--TGDIIGFLNSDDTLLPGALLAVVAAFAEHPE--VDVVYGDVLLVDENGRVIGRRRPPPFLDKFLL----------YG 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1036291995 163 MVINKQTLqFVKT----RMP--DTLDNIIM-HDWWIYlCTAAFGEVVFDPEPSIWYRQH 214
Cdd:cd06433   140 MPICHQAT-FFRRslfeKYGgfDESYRIAAdYDLLLR-LLLAGKIFKYLPEVLAAFRLG 196
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 5-116 1.93e-07

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 51.08  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   5 SVQILLSTYNGATYLDEQLESLINQKD--VNTQILIRDDGSTDDTISKLNALKQRYPqRVVLYPesNEGVIASF-FDL-I 80
Cdd:cd02525     1 FVSIIIPVRNEEKYIEELLESLLNQSYpkDLIEIIVVDGGSTDGTREIVQEYAAKDP-RIRLID--NPKRIQSAgLNIgI 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1036291995  81 QRSSetFDYYAFCDQDDVWMPNKLARAVAQLREKDE 116
Cdd:cd02525    78 RNSR--GDIIIRVDAHAVYPKDYILELVEALKRTGA 111
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-120 2.58e-07

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 51.20  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   3 KPSVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPEsNEGVIASFFDLIQR 82
Cdd:PRK10073    5 TPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQA-NAGVSVARNTGLAV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036291995  83 SseTFDYYAFCDQDDVWMPN------KLARA----VAQ------LREKDESRPL 120
Cdd:PRK10073   84 A--TGKYVAFPDADDVVYPTmyetlmTMALEddldVAQcnadwcFRDTGETWQS 135
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 8-59 1.56e-06

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 47.57  E-value: 1.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYP 59
Cdd:cd06420     1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEETKELIEEFKSQFP 52
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 8-115 8.90e-06

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 45.64  E-value: 8.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLIN--QKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEGVIASFFDLIQRSSE 85
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAvlEEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRAGFKAARG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1036291995  86 tfDYYAFCD---QDDvwmPNKLARAVAQLREKD 115
Cdd:cd04179    81 --DIVVTMDadlQHP---PEDIPKLLEKLLEGG 108
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 8-116 9.23e-06

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 45.30  E-value: 9.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPESNEG----VIASFFDLIqrs 83
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKENGgkagALNAGLRHA--- 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1036291995  84 seTFDYYAFCDQDDVWMPNKLARAVAQLREKDE 116
Cdd:cd06423    78 --KGDIVVVLDADTILEPDALKRLVVPFFADPK 108
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 4-115 1.04e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 45.82  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   4 PSVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYP-QRVVLYPESNEGVIASFFD--LI 80
Cdd:pfam13641   2 PDVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAARFPdVRLRVIRNARLLGPTGKSRglNH 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1036291995  81 QRSSETFDYYAFCDQDDVWMPNKLARAVAQLREKD 115
Cdd:pfam13641  82 GFRAVKSDLVVLHDDDSVLHPGTLKKYVQYFDSPK 116
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 5-217 1.74e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 45.35  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   5 SVQILLSTYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQrvVLYPESNEGVI--ASFFDLIQR 82
Cdd:pfam10111   1 SVVIPVYNGEKTHWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDHNLQ--VYYPNAPDTTYslAASRNRGTS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  83 SSETfDYYAFCDQDDVWMPNKLARAVAQLREKDESR----PLMYcSATQMVSQNLEPLK-----VWPADIPRPL-SLYNA 152
Cdd:pfam10111  79 HAIG-EYISFIDGDCLWSPDKFEKQLKIATSLALQEniqaAVVL-PVTDLNDESSNFLRrggdlTASGDVLRDLlVFYSP 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1036291995 153 LIENVC-VGCTMVINKQtlQFVKTRMPDtlDNIIMH---DWWIYLCTAAFGEVVFDPEPSIWYRQHQNN 217
Cdd:pfam10111 157 LAIFFApNSSNALINRQ--AFIEVGGFD--ESFRGHgaeDFDIFLRLAARYPFVAVMPPQLLYRLSAKS 221
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 8-104 3.32e-05

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 44.37  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDEQLESLINQKDVNT-QILIRDDGSTDDTISKLNALKQRYP-QRVVLYPESNE-----GVIASFFDLI 80
Cdd:cd06913     1 IILPVHNGEQWLDECLESVLQQDFEGTlELSVFNDASTDKSAEIIEKWRKKLEdSGVIVLVGSHNspspkGVGYAKNQAI 80

                          90       100
                  ....*....|....*....|....
gi 1036291995  81 QRSSETfdYYAFCDQDDVWMPNKL 104
Cdd:cd06913    81 AQSSGR--YLCFLDSDDVMMPQRI 102
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 8-117 6.75e-05

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 43.07  E-value: 6.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNG--ATYLDEQLESLINQKDVNTQILIRDDGS-TDDTISKLNALKQRYPQRVVLYPES-------NEGVIASFF 77
Cdd:cd04195     2 VLMSVYIKekPEFLREALESILKQTLPPDEVVLVKDGPvTQSLNEVLEEFKRKLPLKVVPLEKNrglgkalNEGLKHCTY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1036291995  78 DLIQRSsetfdyyafcDQDDVWMPNKLARAVAQLREKDES 117
Cdd:cd04195    82 DWVARM----------DTDDISLPDRFEKQLDFIEKNPEI 111
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 12-115 5.30e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 40.31  E-value: 5.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995  12 TYNGATYLDEQLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPQRVVLYPEsNEGVIASFFDLIQRSSET-FDYY 90
Cdd:cd04185     5 TYNRLDLLKECLDALLAQTRPPDHIIVIDNASTDGTAEWLTSLGDLDNIVYLRLPE-NLGGAGGFYEGVRRAYELgYDWI 83

                          90       100
                  ....*....|....*....|....*
gi 1036291995  91 AFCDQDDVWMPNKLARAVAQLREKD 115
Cdd:cd04185    84 WLMDDDAIPDPDALEKLLAYADKDN 108
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 8-64 3.62e-03

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 37.84  E-value: 3.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036291995   8 ILLSTYNGATYLDE---QLESLINQKDVNTQILIRDDGSTDDTISKLNALKQRYPqRVVL 64
Cdd:cd04187     1 IVVPVYNEEENLPElyeRLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDP-RVKV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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