|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-397 |
1.19e-102 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 308.72 E-value: 1.19e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 26 IGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAF 105
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 106 APSFVTILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAAL 185
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 186 AVMFLLHIAKWYAARlgslaqKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYhVSIQQAQ 265
Cdd:cd17478 161 AVALLLLRLRPLKKP------EAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 266 SYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPG 345
Cdd:cd17478 234 LLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPG 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1036601534 346 KIGTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFL 397
Cdd:cd17478 314 NVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-398 |
1.14e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 139.62 E-value: 1.14e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 13 QKPGTTVYPILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIG 92
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 93 LTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPL 171
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 172 GQFGAVWFTLVAALAVMFLlhiakwyaarlgslaqksgkqkktsdntaitksvvsALIIIIFLIFARSWYTSAIGNFYTF 251
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL------------------------------------RFWLLALAYFLVYFALYGFLTWLPT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 252 YAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKR---FVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVL 328
Cdd:COG2271 206 YLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1036601534 329 MSSFSVTVVYAQELVPGKI-GTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:COG2271 286 GGAFGLLWALAAELFPKKArGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-398 |
5.95e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 110.74 E-value: 5.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 20 YPILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLG 99
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 100 ILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVW 178
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIAlVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 179 FTLVAALAVMFLLhiakWYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYtsAIGNFYTFYAMDTYH 258
Cdd:COG2223 164 ILGILLLVVAVLA----WLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI--GFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 259 VSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFA--GPVLAYGVLALIGLVLMSSFSVTV 336
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlgSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036601534 337 VYAQELVPGK-IGTMSGLtVGLAFGMGA-IGAVALGALIDTAG-LTPTMIAIAFLPVLGILAFLL 398
Cdd:COG2223 318 ALVPDIFPTKnAGAVYGL-VGAAGGLGGfLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-364 |
2.59e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 102.74 E-value: 2.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 22 ILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGIL 101
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 102 GLAFAPSFVTILCCVFFIGLGSAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFT 180
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 181 LVAALAVMFLLhiakwyAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIfarSWYTSAIGNFYTFYAMDTYHVS 260
Cdd:COG2814 171 AVLALLALLLL------LRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLL---GFGFFALFTYLPLYLQEVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 261 IQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAG-PVLAYGVLALIGLVLMSSFSVTVVYA 339
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGsLWLLLLALFLLGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|....*.
gi 1036601534 340 QELVPGKI-GTMSGLTVGLAFGMGAI 364
Cdd:COG2814 322 AELAPPEArGRASGLYNSAFFLGGPL 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-398 |
1.91e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.14 E-value: 1.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 22 ILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGIL 101
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 102 GLAFAPSFVTILCCVFFIGLGSAIF----HPEGSRVAYMAAGTKRGLAQSIYQVGGnsgqAMAPLITALILvpLGQFGAV 177
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLdvaaNPYVAALGPETAASRLNLLHAFFSLGA----LLGPLLGGLLI--LLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 178 WFTLVAALAVMFLLHIAkwyAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFArSWYTSA---IGNFYTFYAM 254
Cdd:COG0738 163 WHLPYLILAVLLLLLAL---LFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAI-FLYVGAegaIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 255 DTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFG-KRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFS 333
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036601534 334 VTVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:COG0738 319 TIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-397 |
1.16e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.71 E-value: 1.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 26 IGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAF 105
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 106 APSFVTILCCVFFIGLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAA 184
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 185 LAVMFLLHIAKWYAARLGSLAQKSGKQKKTSdNTAITKSVVSALIIIIFLIFARSWYTSAIG--NFYTFYAMDTYHVSIQ 262
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKS-VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSfsTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 263 QAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVIL--GSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQ 340
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLliGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1036601534 341 ELVP-GKIGTMSGLTVGLAFGMGAIGAVALGALID-TAGLTPTMIAIAFLPVLGILAFL 397
Cdd:cd06174 320 ELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
43-398 |
1.67e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.39 E-value: 1.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 43 MFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLG 122
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 123 SAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHIAKWYAARL 201
Cdd:cd17325 98 SAAVWPAAmALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 202 GSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARswyTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFL 281
Cdd:cd17325 178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFA---FGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 282 GGPLADRFGKRFVILGSLLCSAPLAILLPFA-GPVLAYGVLALIGLVLMSSFSVTVVYAQELVP-GKIGTMSGLtVGLAF 359
Cdd:cd17325 255 AGKLSDRIGRKPLILIGLLLSAVALLLLPLAtSFWLLLLLLALLGLGLGLVFPATLALLADIVPpEGRGTAMGL-FNTAF 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1036601534 360 GMG-AIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17325 334 SLGmVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
40-397 |
2.09e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 83.06 E-value: 2.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 40 IPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFI 119
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 120 GLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQvggnSGQAMAPLITALILVPL-GQFGAVWFTLVAALAVMF--LLHIAK 195
Cdd:cd17475 95 GAGYGSVQPGGGRaIMRWFPPRERGLAMGIRQ----TGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILaaVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 196 WYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAignFYTFYAMDTYHVSIQQAQSYIFVFLLFG 275
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLT---FLLLFLHDHLGLSVVAAGALLAVAQLGG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 276 AVGTFLGGPLADRF--GKRFVILGSLLCSAPLAILL-----PFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVP-GKI 347
Cdd:cd17475 248 ALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVlsllsPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGpEQA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1036601534 348 GTMSGLTVGLAFGMGAIGAVALGALID-TAGLTPTMIAIAFLPVLGILAFL 397
Cdd:cd17475 328 GTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-366 |
3.10e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.08 E-value: 3.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 23 LIIIGICHMLNDSLqaVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILG 102
Cdd:pfam07690 1 LFLAAFLAALGRSL--LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 103 LAFAPSFVTILCCVFFIGLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTL 181
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 182 VAALAVMFLLhiakWYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSI 261
Cdd:pfam07690 159 ILSLLAAVLL----LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 262 QQAQSYIFVFLLFGAVGTFLGGPLADRFGKR----FVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVV 337
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 1036601534 338 YAQELVP-GKIGTMSGLTVGLAFGMGAIGA 366
Cdd:pfam07690 315 LVSDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-397 |
4.52e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 79.13 E-value: 4.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 39 VIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFF 118
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 119 IGLGSAIFHPEGSRVA-YMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLhiakWY 197
Cdd:cd17324 97 AGLAHGGFWAIAAAYAaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLL----WR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 198 AARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFArswYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAV 277
Cdd:cd17324 173 LLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFG---GFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 278 GTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAG-PVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKIGTMSGLTVG 356
Cdd:cd17324 250 GSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPsPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLA 329
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1036601534 357 LAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFL 397
Cdd:cd17324 330 AYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
38-406 |
1.11e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.91 E-value: 1.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 38 AVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVF 117
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 118 FIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHIAKWY 197
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 198 AARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFlifarswYTSAIGNFYTFYAmdTYHVSIQQAQSYIFVFLLFGAV 277
Cdd:COG2807 195 RPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLL-------YYAVVAWLPPILR--DAGLSAATAGLLLSLFQLAGIP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 278 GTFLGGPLADRFG-KRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELV--PGKIGTMSGLT 354
Cdd:COG2807 266 GSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMA 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1036601534 355 VGLAFGMGAIGAVALGALID-TAGLTPTMIAIAFLPVLGILAFLLPSDQKLRE 406
Cdd:COG2807 346 QSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-398 |
2.29e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.68 E-value: 2.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 22 ILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGIL 101
Cdd:cd17319 4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 102 GLAFAPSFVTILCCVFFIGLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAvwFT 180
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKaLAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA--FI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 181 LVAALAVMFLLHIAKWYAARLGSLAQKSGKQkktsdntaitksvvsaliiiiflifarsWYTSAIGNFYTFYAMDTYHVS 260
Cdd:cd17319 162 IEGLLGLLLAVLWWFYLRQVWGLALGYFGIN----------------------------YALYGLLTWLPTYLKQARGFS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 261 IQQAQSYIFVFLLFGAVGTFLGGPLADRFG----KRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTV 336
Cdd:cd17319 214 LKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036601534 337 VYAQELVPGK-IGTMSGLTVGLAFGMGAIGAVALGALID-TAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17319 294 SLPADLLPGEaAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
37-396 |
2.26e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 67.58 E-value: 2.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 37 QAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCV 116
Cdd:cd17477 12 SGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 117 FFIGLGSAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALIlvplGQFGAVWFTLVAALAVMFLLHIAk 195
Cdd:cd17477 92 FVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV----GTAGALPFLIAAVLLLLALVPLL- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 196 wyaarLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFArswyTSAIGNFYTFYAMDTyHVSIQQAQSYIFVFLLFG 275
Cdd:cd17477 167 -----LTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFL----EGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 276 AVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAG--PVLAYGVLALIGLVLMSSFSVTVVYAQELVPGK--IGTMS 351
Cdd:cd17477 237 LLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPglPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDelVAANA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1036601534 352 GLTVGLAFGmGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAF 396
Cdd:cd17477 317 ALLLLYGLG-SVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
45-381 |
3.08e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 64.32 E-value: 3.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 45 PILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSA 124
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 125 I-FHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVwFTLVAALAVMFLLHIAKWYAAR--- 200
Cdd:TIGR00881 99 MgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV-FIVPGIIAIIVSLICFLLLRDSpqs 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 201 --LGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSaIGNFYTF------------YAMDTYHVSIQQAQS 266
Cdd:TIGR00881 178 cgLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYIS-LGYVFVYvvrtgildwsplYLTQEKGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 267 YIFVFLLFGAVGTFLGGPLADRF--GKRFVILGS----LLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQ 340
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFfmalIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIAS 336
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1036601534 341 ELVPGK-IGTMSGLtVGLAFGMGAIGAVA-LGALIDTAGLTPT 381
Cdd:TIGR00881 337 ELAPKKaAGTAAGF-VGFFAYLGGILAGLpLGYLADGFGWAGA 378
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
57-399 |
7.71e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 63.09 E-value: 7.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 57 QLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSRVAYM 136
Cdd:cd17371 35 EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 137 AAGTKR-----GLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFL-LHI---AKWYAARLGSLAQK 207
Cdd:cd17371 115 YVPARHrgkalGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIrRFVkepPQWQAARAARRHFA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 208 SGKQKKTSDNTAITKsvVSALIIIIFLIFARSWYtsAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLAD 287
Cdd:cd17371 195 DRPSLRELFSPPLLR--TTLLASLLATGALGGYY--GITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLAD 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 288 RFGKRF-VILGSLLCSAPLAILLPF-AGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKI-GTMSGLTVGLAFGMGAI 364
Cdd:cd17371 271 RIGRRNnFALFALGSAISILLYFFLpLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVrATAQGFCYNVGRIIGAL 350
|
330 340 350
....*....|....*....|....*....|....*...
gi 1036601534 365 GAVALGALIDTAGLTP---TMIAIAFLPVLgILAFLLP 399
Cdd:cd17371 351 FPFLVGFLATSGSLGTaiaVFAAVYYIAGL-VLALLLP 387
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
24-397 |
1.04e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 59.48 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 24 IIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPI-GLTASMLGILG 102
Cdd:cd17370 2 WLLGLVSLFADISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlGYGLSALAKPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 103 LAFAPSFVTILCCVFFIGLGSAIFHPegSR---VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLItALILVPLGQFG---A 176
Cdd:cd17370 82 LALAGSWQLVLLLRILERLGKGIRTP--PRdalLADATPPSGRGKAFGLHRALDTLGAVLGPLL-AALLLYLLGGNyrtI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 177 VWFTLVAALAVMFLLHIAKWYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIiiflifarswytsAIGNF-YTFYAMD 255
Cdd:cd17370 159 FLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALF-------------ALGNFsFAFLILR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 256 TYHVSIQQAQSYIF--VFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSF- 332
Cdd:cd17370 226 AQELGLSAALIPLLyaLFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQe 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1036601534 333 SVTVVYAQELVPGKI-GTMSGLtVGLAFGMGA-IGAVALGALIDTAGLTPTMIAIAFLPVLGILAFL 397
Cdd:cd17370 306 SIERAAVADLVPAELrGTAYGL-FNTVVGIGWlLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
75-398 |
1.19e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.54 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 75 VVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGG 153
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGAsTYVAEFAPSKRRGFALGLLQSGW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 154 NSGQAMAPLITALILVPLGQ-FGAVWFTLVAALAVMFLLHIAKwyaarlgslaqksgkqkktsdntaitksvvSALIIII 232
Cdd:cd17316 135 ALGALLAALVASLLIPLLSGdWGWRILFLIGALPALLALLLRR------------------------------RTLLLIL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 233 FLIFARSWYTSAIGNFYTFYAMdTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFA 312
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQT-VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 313 G---PVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKI-GTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFL 388
Cdd:cd17316 264 LsgsPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
330
....*....|
gi 1036601534 389 PVLGILAFLL 398
Cdd:cd17316 344 LAIVALIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
37-397 |
1.48e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 37 QAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDK------RPRPYALpIGLTASMLGILGLAFAPS-- 108
Cdd:COG2211 27 GLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrtrwgRRRPWIL-IGAIPLALSFVLLFTAPDls 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 109 ----FVTILCCVFFIGLGSAIFhpegsRVAYMAAGT-------KRGLAQSIYQVGGNSGQAMAPLITALILVPLG---QF 174
Cdd:COG2211 106 ptgkLIYALVTYLLLGLAYTLV-----NIPYSALGAeltpdyeERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 175 GAVWFTLVAALAVMFLLHIAKWYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFArswyTSAIGNFYTFYAM 254
Cdd:COG2211 181 GYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA----LALVAALLLYYFK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 255 DTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGP---VLAYGVLALIGLVLMSS 331
Cdd:COG2211 257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnlWLLLVLAALAGIGLGAI 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 332 FSVT------VVYAQELVPGKIGT---MSGLTVGLAFGMgAIGAVALGALIDTAGLTP---------TMIAIAFLPVLGI 393
Cdd:COG2211 337 LVLPwamladVVDYDEWKTGRRREglyFGIFTFAIKLGQ-ALAGALAGLLLALFGYVAgaaqspsalTGIRLLFFLLPAV 415
|
....
gi 1036601534 394 LAFL 397
Cdd:COG2211 416 LLLL 419
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-397 |
2.91e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 2.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 37 QAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCV 116
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 117 FFIGLGSAIFHP-EGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALilvpLGQFGAVW-FTLVAALAVMFLLHIA 194
Cdd:cd17474 95 ALQGIGAAGLGPlALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL----LAAISWRYpFFLLAALIPVAFLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 195 KWyaarlgslaqksgKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAM---------DTYHVSIQQAQ 265
Cdd:cd17474 171 FL-------------LPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFltylpflleLLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 266 SYIFVFLLFGAVGTFLGGP-LADRFGKRFVILGSLLCSAPLAILLPFA-GPVLAYGVLALIGLVLMSSFSVTVVYAQELV 343
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYALSLLLLGFVpSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1036601534 344 PGKI-GTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPT--MIAIAFLPVLGILAFL 397
Cdd:cd17474 318 PEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPflVGAAIALAAAVLLALL 374
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-367 |
3.06e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.42 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 40 IPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFA-PSFVTILCCVFF 118
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 119 IGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSG----QAMAPLITALILVPLGQFG-------AVWFTLVAALAV 187
Cdd:cd17341 98 LGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGvavsQLLAPLIAGAIVFDGGFVGwrnaffvPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 188 MFLlhiAKWYAARLGSLAQKSGKQKKTSDNtaitksvvsaliiiiflifARSWYTS-----------AIGNFYTFYAMDT 256
Cdd:cd17341 178 LLF---GDDLPTGKASALEFLKVQLAVLKN-------------------YRTWILSllygvtfgsfvGFSNVLPTYFKTR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 257 YHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLAliGLVLMSSFSVTV 336
Cdd:cd17341 236 FGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVL--FLALFVALGLGA 313
|
330 340 350
....*....|....*....|....*....|..
gi 1036601534 337 VYAQELVPGKIGTMSGLTVGLAFGM-GAIGAV 367
Cdd:cd17341 314 GAGNGSVFRMVPFIFRRELGAVTGLvGAIGGL 345
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
62-398 |
9.88e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.51 E-value: 9.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 62 AFTLNM-VSSVMQPVVGWYTDKR-PRPyALPIGLTASMLGILGLAFAPS---FVTILCCVFFIGLGsAIFHPEGSRVAYM 136
Cdd:cd17355 43 AFTVGLlAFGLAQPFVGRLLDRFgPRR-VMLLGLLLLAAGLVLLALATSlwqLYLLWGLLGGGGAG-TLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 137 AAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHIAKWyaARLGSLAQKSGKQKKTSD 216
Cdd:cd17355 121 WFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLR--RRPADLALRAYDDASPAS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 217 NTAITKSVVSAliiiiflifaRSWYTSAIGNF---YTFYAMDTYHVSI--------QQAQSYIFVFLLFGAVGTFLGGPL 285
Cdd:cd17355 199 PGSTLKEALRS----------ASFWLLALAFFlcgFAVVGLIVHLVPYladrgispAAAAVALALIGLFNIVGRLLSGWL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 286 ADRFGKRFVILGSLLCSAPLAILLPFAG--PVLAYGVLALIGLVLMSSFSVTVVYAQELVPGK-IGTMSGLTVGLAFGMG 362
Cdd:cd17355 269 GDRYSPRRLLAASYALRALGLALLLLLPfpPLALLLFAALFGLGWGATVPLTAALAARYFGARsYGTLFGLVFAPHQLGS 348
|
330 340 350
....*....|....*....|....*....|....*.
gi 1036601534 363 AIGAVALGALIDTAGLTPTMIAIAFlpVLGILAFLL 398
Cdd:cd17355 349 ALGPWLGGLLYDRTGSYTAAWALAV--ALGLIAALL 382
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
45-373 |
1.01e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 56.56 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 45 PILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSA 124
Cdd:cd17333 20 PSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 125 IFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILvplgQFGAVWFTLVAALAVMFLLHIAKWYAARLGSL 204
Cdd:cd17333 100 ILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLL----TSELSWSWAYLIIGLIYLLLAILILLTLFPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 205 AQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWY--TSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLG 282
Cdd:cd17333 176 PSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVgaETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 283 GPLADRFG-KRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKigtmSGLTVGLAFGM 361
Cdd:cd17333 256 GPISRRIKpHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA----KGKGTSVLLAA 331
|
330
....*....|..
gi 1036601534 362 GAIGAVALGALI 373
Cdd:cd17333 332 GSIGGAIIPFIM 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-195 |
1.44e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.05 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 19 VYPILIIIGICHMLNDSLQAVIPAMfpiLERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASML 98
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLY---AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 99 GILGLAFAPSFVTILCCVFFIGLGSAIFHP-EGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAV 177
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357
|
170
....*....|....*...
gi 1036601534 178 WFTLVAALAVMFLLHIAK 195
Cdd:cd17325 358 LAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-398 |
2.43e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 2.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 38 AVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVF 117
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 118 FIGLGSAIFHPEGSR-VAYMAAGTKRGLAQSIYQVGGNSGQAMAPLItALILVPLGQFGAVW----FTLVAALAVMFLLH 192
Cdd:cd17329 97 LTGFGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLL-GGLLLLYSFRLLFLaaavLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 193 IAKWYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFlifarswytSAIGNFYTFYAMDTYHVSIQQAQSYIFVFL 272
Cdd:cd17329 176 ETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIY---------FQLESTLPVYVVEILGLGESLLGLLLALNA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 273 LFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAG---PVLAYGVLALIGLVLMSSFSVTVVyAQELVPGKIGT 349
Cdd:cd17329 247 LLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANtlaVLILAMIVLTLGEMLVFPAVQTLV-AALAPPDKRGS 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1036601534 350 MSGLtVGLAFGMG-AIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17329 326 YMGF-YALAWGLGrAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-398 |
6.68e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.14 E-value: 6.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 56 TQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSRVAY 135
Cdd:cd17489 31 AVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 136 MAAGTKR-GLAQSIYQVGGNSGQAMAPLItALILVPLGQFGAV-WFTLVAALAVMFLLHIAKWYAARLGSLAQKSGKQKK 213
Cdd:cd17489 111 DIIPPSRrGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLfIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 214 TSDNTAITKSVVSALIIIIFlifarswyTSAIGNFYTFYAMdtyhvsiQQAQSYIFVFLLFGAVGTFLGGP----LADRF 289
Cdd:cd17489 190 RLVEKKVLPPALILFLASIA--------YGAISTFLPLYAA-------ERGISNAGLFFTVYAIALLLSRPfsgkLSDRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 290 GKRFVIL-GSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVP--GKIGTMSGLTVGLAFGMGaIGA 366
Cdd:cd17489 255 GPKTVIIpGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPphRRGAANGTFFIFFDLGIG-LGG 333
|
330 340 350
....*....|....*....|....*....|..
gi 1036601534 367 VALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17489 334 LLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
270-375 |
1.04e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 53.35 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 270 VFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVL-ALIGLVLMSSFSVTVVYAQELVPGKIG 348
Cdd:cd17317 33 IFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLrFLVGVTSAGIFTVGFVLGMEIVGPKYR 112
|
90 100
....*....|....*....|....*..
gi 1036601534 349 TMSGLTVGLAFGMGAIGAVALGALIDT 375
Cdd:cd17317 113 SFVGILFGLFWALGYMLLALLAYLIRD 139
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-397 |
3.40e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.85 E-value: 3.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 39 VIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFF 118
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 119 IGLGSAIFHP-EGSRVAYMAAGTKRGLAQSIYQ------------VGGNSGQAMAPLITALILVPLgqfgavwFTLVAAL 185
Cdd:cd17328 97 VGIGEASYSPiAPTIIADLFPKEKRTRALGVFYfaiplgsglgyvVGGLVAQATGGWRWAFRVTGV-------LGVLLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 186 AVMFLLHIakwyaARLGSLAQKSGKQKKTSDNTAITKSVVS--ALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQ 263
Cdd:cd17328 170 LLLLFVRE-----PPRGAAEGGVMAKSTATSFLADLKALAKnpSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 264 AQSYIFVFLLF----GAVGTFLGGPLADRFGKR------FVILGSLLCSAPLAILLPFAG---PVLAYGVLALIGLVLMS 330
Cdd:cd17328 245 SADVGLIFGAItciaGVLGVLLGGILADRLRRKtpradpLVCAVGLLAAAPFLFLALVLAlsnLLLAWVLLFLGEFLLSL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 331 SFSVTVVYAQELVPGK--------IGTMSGLtVGLAFGMGAIGAV--ALGALIDT-----AGLTPTMIAIAFLPVLGILA 395
Cdd:cd17328 325 NWAPVFAILLYVVIPTrrstasaiQILLSHL-LGDAGSPYLIGLIsdLLRQNKDSplaeaASLQYALLLCSFVLVLGGFF 403
|
..
gi 1036601534 396 FL 397
Cdd:cd17328 404 FL 405
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
71-398 |
4.50e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 4.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 71 VMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAP-----SFVTILCCVFFIGLGSAIFHP-EGSRVAYMAAGTKRGL 144
Cdd:cd06173 49 LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPaRQALLPELVPKEQLVR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 145 AQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLhiakwyaarlGSLAQKSGKQKKTSDNTAITKSV 224
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL----------LFIRRPPPAAPGESSSLLLRDLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 225 VSALIIIIFLIFARSWYTSAIGNFYTF--------YAMDTYHVSiqqaQSYIFVFLLFGAVGTFLGGPLADRFGKRF--- 293
Cdd:cd06173 199 EGLRYLRRSPLLRLLLLALALFALLGGaltvllplLAKEVLGGG----AAGYGLLLAAFGVGALLGALLLGRLSKRRrrg 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 294 --VILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKI-GTMSGLTVGLAFGMGAIGAVALG 370
Cdd:cd06173 275 rlLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLAG 354
|
330 340
....*....|....*....|....*...
gi 1036601534 371 ALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd06173 355 LLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
260-398 |
1.01e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 260 SIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPF--AGPVLAYGVLALIGLVLMSSFSVTVV 337
Cdd:cd17365 204 SLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVspASLVLLYVLVFLAGACVNGAQVGLYA 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036601534 338 YAQELVPGKIgtmSGLTVGLAFGMGAIGAVA---LGALIDTAGLTPTMIAIAFLP--VLGILAFLL 398
Cdd:cd17365 284 LAARFYPTEV---RATGVGWALGVGRLGAILgplLGGLLLAAGLGPESVFLALAIpaALGALAVLL 346
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-160 |
3.36e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 22 ILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGIL 101
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 102 GLAFAPSFVTILCCVFFIGLGSAIFHPEGSRVAYMAAGTK-RGLAQSIYQVGGNSGQAMA 160
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEaRGRASGLYNSAFFLGGPLA 348
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
22-398 |
3.71e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.76 E-value: 3.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 22 ILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIiAFTLNMVS-SVMQPVVGWYTDKRPRPYALPIGLTASMLGI 100
Cdd:cd17353 4 LVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVAL-AFTLTIVFlAISAPFAGRLVDRGGPRKAILIGGILFGLGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 101 LGLAFAPSFVTILCCVFFI-GLGSAIFHPEGSRVAYMAAGTKRGLAQSIYqvggNSGQAMAPLITALILVPLGQFGAVWF 179
Cdd:cd17353 83 ILSAFAISLPLLFLGYGVLgGIGAGIGYITPVSTAVKWFPDKRGLATGIV----IAGFGLGSLIFSPLIAYLINTVGVPT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 180 TLVAALAVMFLLhiakwyAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARS------WYTSAIGNFY---- 249
Cdd:cd17353 159 TFLILGIIFLII------IVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTptfwllWLMFFLNATAglml 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 250 ----TFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAG--PVLAYGVLAL 323
Cdd:cd17353 233 igqaKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGsvAVLFVLGVAL 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1036601534 324 IGLVLMSSFSVTVVYAQELVPGK-IGTMSGLtVGLAFGMGAIGAVALGALIDTA-GLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17353 313 IGFCYGGGFALFPALTADFFGTKnAGTNYGL-LYTAKGVGGLIGPIIAAYVLYTgGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
242-406 |
5.84e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 5.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 242 TSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLA-YGV 320
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLlLVL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 321 LALIGLVLMSSFSVTVVYAQELVPGKIGTMSGLTVGLAFGMG-AIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLLP 399
Cdd:pfam07690 92 RVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGaALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP 171
|
....*..
gi 1036601534 400 SDQKLRE 406
Cdd:pfam07690 172 RPPPESK 178
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
269-372 |
7.56e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 47.67 E-value: 7.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 269 FVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLA-LIGLVLMSSFSVTVVYAQELVPGKI 347
Cdd:cd17374 42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRfLAGFAVSGISINTLILGTEWTTPRH 121
|
90 100
....*....|....*....|....*
gi 1036601534 348 GTMSGLTVGLAFgmgAIGAVALGAL 372
Cdd:cd17374 122 RALAITLTSCFF---SIGQMLLAGL 143
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
253-398 |
1.90e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.53 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 253 AMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGpvlAYGVLALI----GLVL 328
Cdd:cd17371 25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ---NYWQLLILralaGLGF 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 329 MSSFSVTVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIdtAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17371 102 GGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL--FPLLPPEIAWRVLFLLGALPALL 169
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-194 |
2.42e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 4 AAPLKEKTVQKPGTTVYPILIIIGICHMLNDslqaVIPAMFP-ILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDK 82
Cdd:cd17473 184 ASPGAATAAALPWKRVLPIYFLAFLAMLLFY----VIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 83 RPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGGNSGQAMAP 161
Cdd:cd17473 260 LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLnSWAMSLVPPELRGRAMGIVTSAFFLGQFLSP 339
|
170 180 190
....*....|....*....|....*....|...
gi 1036601534 162 LITALILVPLGQFGAVWFTLVAALAVMFLLHIA 194
Cdd:cd17473 340 LVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
43-200 |
3.33e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 43 MFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDK--RPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIG 120
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 121 LGSAIFHP-EGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHIAKWYAA 199
Cdd:COG2271 283 FGLGGAFGlLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
.
gi 1036601534 200 R 200
Cdd:COG2271 363 K 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
45-398 |
5.77e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 44.93 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 45 PILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPS--------FVTILCCV 116
Cdd:cd17345 27 PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSatssvglmFILLFLNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 117 FFIGLGSAifhPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLG---QFGAVWF----TLVAALAVMF 189
Cdd:cd17345 107 WFQGMGWP---PSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFpaiiAIIVAVIVLF 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 190 LLH----------IAKWYAARlGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAIG--NFYTFYAMDTY 257
Cdd:cd17345 184 LGKdtpeseglppIEEYKGDY-PEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGilDWAPTYLSEVK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 258 HVSIQQAQSYIFVFLLFGAVGTFLGGPLADRF--GKR------------FVILGSLLCSAPLAILLP-FAGPVLAYGVLA 322
Cdd:cd17345 263 GFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRaptgiifmilviVALIVYWLAPNVLVDLIAlIALGFLIYGPVM 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1036601534 323 LIGlvlmssfsvtvVYAQELVPGK-IGTMSGLTVGLAFGMGAIGA-VALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17345 343 LIG-----------LQALELVPKKaAGTAAGLTGLFGYLGGSVLAtALIGIIVDHFGWNGGFIVLLASCILAIIFLAL 409
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
273-396 |
7.20e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.50 E-value: 7.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 273 LFG-AVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLALI-GLVLMSSFSVTVVYAQELVPGKIGTM 350
Cdd:cd17365 44 LFGmAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLtGLGLGAAMPNAITLVSEYAPARRRSL 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1036601534 351 SGLTVGLAFGMGAIGAVALGA-LIDTAGLTPTMIAIAFLPVLGILAF 396
Cdd:cd17365 124 AVTLMFCGYPLGAALGGFLAAaLIPAFGWRSVFLLGGVPPLILLPLL 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
242-406 |
2.83e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 242 TSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYgVL 321
Cdd:cd17329 15 FFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLF-AI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 322 ALIGLVLMSSFSVTVVYAQ--ELVPGKIGTM--SGLTVGLAFGMgAIGAVALGALIDTAGLTPTMI-AIAFLPVLGILAF 396
Cdd:cd17329 94 ALVLTGFGGGLFEPASEAMiaDVTTPENRTRafSLLYWAINLGV-AIGPLLGGLLLLYSFRLLFLAaAVLFLLAALVLLF 172
|
170
....*....|
gi 1036601534 397 LLPSDQKLRE 406
Cdd:cd17329 173 LLPETRPKRR 182
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
70-398 |
2.86e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.56 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 70 SVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIfhpeGSRVAYMA-----AGTKRGL 144
Cdd:cd17320 48 ALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA----GSVVARAIvrdlySGAELAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 145 AQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLlhIAKWYAARLGSLAQKSGKQKKTSDNTAITKS- 223
Cdd:cd17320 124 IFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL--VLLFLPETLPEEKRKPLLSSLLRAYKRVLKNr 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 224 --VVSALIIIIFLIFARSWYTSAignfyTFYAMDTYHVSIQQAqSYIFVFLLFGA-VGTFLGGPLADRFGKRFVILGSLL 300
Cdd:cd17320 202 rfLGYALALGLSFAGLFAYLAAA-----PFIYIEQLGLSPAQF-GLLFALNAIALiLGSLLNGRLVRRFGPRRLLRLGLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 301 CSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVY------AQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALID 374
Cdd:cd17320 276 LLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFpnatslALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN 355
|
330 340
....*....|....*....|....
gi 1036601534 375 TaGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17320 356 G-TALPMGLLILVLGLLALLLLIL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
38-191 |
3.49e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.11 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 38 AVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVF 117
Cdd:COG0477 31 TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARA 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036601534 118 FIGLGSAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLL 191
Cdd:COG0477 111 LQGIGAGGLMPGAlALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLR 185
|
|
| COG4262 |
COG4262 |
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ... |
260-407 |
4.01e-04 |
|
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];
Pssm-ID: 443404 [Multi-domain] Cd Length: 426 Bit Score: 42.16 E-value: 4.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 260 SIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLL-----CSAPL-----AILLPFAGPVLAYGVLALIGLV-- 327
Cdd:COG4262 41 SVLQFSIVIGVFLFAMGLGSYLSRRVADRLLRAFIRLELLLallggLSALLlfalfAFLLGALFLLALYLLVLLIGLLig 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 328 LMSSFSVTVVYAQELVPGK-IGTMSGL-TVGlafgmGAIGAVALG-ALIDTAGLTPTMIAIAFLPVLGILAFLLPSDQKL 404
Cdd:COG4262 121 AEIPLLMRLLERRREELGSaVGRVYAAdYLG-----ALVGSLLFPfLLLPALGLVRTALLFGLLNAAVALVLLWLFRKRL 195
|
...
gi 1036601534 405 REW 407
Cdd:COG4262 196 RRK 198
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
45-398 |
4.24e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 42.25 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 45 PILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSA 124
Cdd:cd17393 23 PAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 125 I----FHPEGSRVAymAAGTKRGLA--QSIYQVGGNSGQAMAPLITALilvplgQFGAVWFTLVAALAVMFLLHIAKWYA 198
Cdd:cd17393 103 AldvaMNAQGVAVE--RAYGRPIMSslHAMWSLGGLAGALLGAAAIGA------GVSPGVHLLAAAVLLLLAALVAIRAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 199 ARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIFARSwytSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGAVG 278
Cdd:cd17393 175 LPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAE---GAAADWSALYLRDVLGASAALAALGYAVFSLAMTVG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 279 TFLGGPLADRFGKRFVILGSLLCSApLAILLPFAGPVLAYGVL--ALIGLVLMSSFSVTVVYAQELVPGKIGTMSGLTVG 356
Cdd:cd17393 252 RLFGDRLVDRFGDVAVLRAGALLAA-LGLLLALLAPSVWVALAgfALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVAT 330
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1036601534 357 LAFGMGAIGAVALGALIDTAGLTPTMIAIAflpVLGILAFLL 398
Cdd:cd17393 331 LGYLGFLVGPPLIGFLADATGLRTAFLVVA---LLALLVALL 369
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
67-368 |
4.48e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 42.28 E-value: 4.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 67 MVSSVMQPV----VGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFH------PEGSRVAYM 136
Cdd:cd17367 47 AVGFLMRPIggwlFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIGIWAPIILLLARLLQglsvggEYGTSATYL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 137 ---AAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLG--QFGA----VWFTLVAALAVmfllhIAKWYAARLGSLAQK 207
Cdd:cd17367 127 sevAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGedQMAAwgwrIPFLLGGVLAV-----VVLWLRRGLEETESF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 208 SGKQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAignFYTF------YAMDTYHVSIQQAQSYIFVFLLFGAVGTFL 281
Cdd:cd17367 202 EAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLA---FYTWttylqkFLVNTAGFSKGDATWITTAALLVFMLLQPL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 282 GGPLADRFGKR-----FVILGSLLcSAPLAILLPFAGPVLAYGVLALIGLVLMSSF-SVTVVYAQELVPGKIGTmSGLTV 355
Cdd:cd17367 279 GGRLSDRIGRRplllfFGIGGTLA-TVPLLSALDHTDSPYTAFALVLVGLVFLSGYtSINAVVKAELFPTHVRA-LGVGL 356
|
330
....*....|...
gi 1036601534 356 GLAFGMGAIGAVA 368
Cdd:cd17367 357 PYALAVAIFGGTA 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
255-403 |
5.32e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 255 DTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPvlaYGVL----ALIGLVLMS 330
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS---FALLllarALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 331 SFSVTVVYAQELVP-GKIGT-----MSGLTVGLAFGmgaigaVALGALI-DTAGLTPTMIAIAF--LPVLGILAFLLPSD 401
Cdd:cd17324 104 FWAIAAAYAADLVPpEKRGRaiglvFSGLTLGLVLG------RPLGGLLgQLLGWRAAFLAIAVlaLLAALLLWRLLPSL 177
|
..
gi 1036601534 402 QK 403
Cdd:cd17324 178 PP 179
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
43-397 |
5.90e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 41.59 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 43 MFPILERSMSLSFTQLGIIAfTLNMVSSVMQPVV---GWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFI 119
Cdd:pfam06779 15 ILPVMIAEGQFSLSQAGLLA-AANYAGYLAGALLasfAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 120 GLGSA-IFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHIAKWYA 198
Cdd:pfam06779 94 GVASAaVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVFPLLPR 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 199 ARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIfarswytsAIGNFYTFYAMDTYHVSIQQAQsYIFVFLLFGAVG 278
Cdd:pfam06779 174 RAPRHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYI--------ITATFLPAMARDGFGGPAAAAL-FWSLFGLAAALG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 279 TFLGGPLADRFGKRFVILGSLLCSApLAILLPFAGPVLAYGVL--ALIGLVLMSSFSVTVVYAQELVPGKIGTMSGLtVG 356
Cdd:pfam06779 245 VLVWLRAAKRWGTRPALTAALLIQA-LGVLLSLLSPSPAGLAVssLLFGGTFMAITSLVMQLARELAPPAPRRLLGL-MT 322
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1036601534 357 LAFGMGAIGAVALGALID--TAGLTPTMIAIAFLPVLGILAFL 397
Cdd:pfam06779 323 ASFGIGQILGPLLASLLTaaTGGLTPALLLAAAALVLAALIVL 365
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
75-367 |
6.34e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 6.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 75 VVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSRVAYMAAGTK-RGLAQSIYQVGG 153
Cdd:TIGR00895 71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMFCGY 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 154 NSGQAMAPLITAlILVPlgQFG-------AVWFTLVAALAVMFLLH-------------IAKWYAARLGSLAQKSGKQKK 213
Cdd:TIGR00895 151 PIGAAVGGFLAG-WLIP--VFGwrslfyvGGIAPLLLLLLLMRFLPesidflvskrpetVRRIVNAIAPQMQAEAQSALP 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 214 TSDNTAITKSVVSALIIIIFLIFARS--WYTSAIGNFYTFYA-------MDTYHVSIQQAQSYIFVFLLFGAVGTFLGGP 284
Cdd:TIGR00895 228 EQKSTQGTKRSVFKALFQGKTARITVllWLLYFMLLVGVYFLtnwlpklMVELGFSLSLAATGGALFNFGGVIGSIIFGW 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 285 LADRFGKRFVILGSLLCSAPLAIL-LPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKIgtmSGLTVGLAFGMGA 363
Cdd:TIGR00895 308 LADRLGPRVTALLLLLGAVFAVLVgSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAI---RATGVGWAIGIGR 384
|
....
gi 1036601534 364 IGAV 367
Cdd:TIGR00895 385 LGAI 388
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
250-328 |
6.52e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 41.68 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 250 TFYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLA-LIGLVL 328
Cdd:COG2270 262 GIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGlLIGLVM 341
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
57-397 |
8.14e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.38 E-value: 8.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 57 QLGIIaFTLNMVSSVM-QPVVGWYTDKR-PRPYALPIGLTASMLGILGLAFAPSFVTILCC-VFFIGLGSAIFhPE---- 129
Cdd:cd17471 33 QIGIF-MTLSALSGIVvSQWLGRLSDRGgDRKPLILLALLAGALGYLLFAFLRNYWVLLLVgVVLLSLGAAAF-PQlfal 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 130 GSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHIAkwyaarlgsLAQKSG 209
Cdd:cd17471 111 AREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFL---------LPSVKP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 210 KQKKTSDNTAITKSVVSALIIIIFLIFARSWYTSAIGNFYT-FYAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADR 288
Cdd:cd17471 182 PAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMpLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 289 FGKRFVILGSLLCSAplailLPFAGPVLAYGVLALIGLVLMSSF------SVTVVYAQELVPGKIGTMSGL-TVGLAFGM 361
Cdd:cd17471 262 FGKRRLLLAGFLAGV-----LFYLGLALATSLWQLIALQLLNAIfigitaGLGISYFQDLMPGQPGLATTLySNASRIGS 336
|
330 340 350
....*....|....*....|....*....|....*.
gi 1036601534 362 gAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFL 397
Cdd:cd17471 337 -LLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-191 |
1.12e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 21 PILIIIGICHMLNDSLQAVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDK-RPRPYALPIGLTASMLG 99
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 100 ILGLAFAPSFVTILCCVFFIGLGSAIFHP-EGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVW 178
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPlSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363
|
170
....*....|...
gi 1036601534 179 FTLVAALAVMFLL 191
Cdd:cd06174 364 LVLAVLLLLAAIL 376
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
269-398 |
1.21e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 269 FVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLV----LMSSFSVTVVYA--QEL 342
Cdd:cd06173 41 AAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAfllgIASAFFGPARQAllPEL 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1036601534 343 VPGK-IGTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd06173 121 VPKEqLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLF 177
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
267-372 |
1.26e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.80 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 267 YIFVFLLFG-AVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVL-ALIGLVLMSSFSVTVVYAQELVP 344
Cdd:TIGR00895 56 FLFSAGLIGmAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILrFLAGLGLGGLMPNLNALVSEYAP 135
|
90 100
....*....|....*....|....*...
gi 1036601534 345 GKIGTMSGLTVGLAFGMGAIGAVALGAL 372
Cdd:TIGR00895 136 KRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
38-396 |
1.34e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 38 AVIPAMFPILERSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVF 117
Cdd:cd17321 13 TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 118 FIGLGSAIFHPEG-SRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLVAALAVMFLLHiakw 196
Cdd:cd17321 93 LQGIGAAAIMPASlALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLAR---- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 197 yaarlgslaqksgkqkktsdntAITKSVVSALIIIIFLifarswytSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA 276
Cdd:cd17321 169 ----------------------TFSGAVLAAFLLGAAL--------GGLLFLLPLYLQGVLGYSPLQAGLALLPLALAML 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 277 VGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGV----LALIGLVLMSSFSVTVVYAQELVP-GKIGTMS 351
Cdd:cd17321 219 VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLllpgLVLLGLGLGLFATPLTNAALSSVPkEKAGAAS 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1036601534 352 GLT-----VGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAF 396
Cdd:cd17321 299 GILntarqLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGF 348
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
270-400 |
1.34e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 270 VFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMSSFSVTVVYAQELVPGKIGT 349
Cdd:cd17330 42 SYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERA 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1036601534 350 MSGLTVGLAFGMGAIGAVALGA-LIDTAGLTPTMIAIAFLPVLGILA--FLLPS 400
Cdd:cd17330 122 KAFGIISAAFGLGFILGPALGGfLSTPYGYALPFLVAAALALLNLVLvlFFLPP 175
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
240-399 |
1.66e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.25 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 240 WYTSAIGNFYTFYAMDTYHVSIQQAQSYIF-VFLLFGAVGTFLGGPLADRFGKRFVILGSLLCSAPLAILLPFAGPVLAY 318
Cdd:cd17315 11 YDLGVINGALLYIAKDLGFGLSTSLQGLVVsSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 319 GVL-ALIGLVLMSSFSVTVVYAQELVP----GKIGTMSGLTVGlaFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVL-- 391
Cdd:cd17315 91 IVGrFLLGLGVGLASVLVPLYISEIAPakirGALGTLNQLMIT--FGILLAYLLGLALSLSPPGWWRLMFALAAVPALlq 168
|
....*...
gi 1036601534 392 GILAFLLP 399
Cdd:cd17315 169 LLLMFFLP 176
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
43-399 |
2.20e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.98 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 43 MFPILERSMSLSFTQLGIIA-------FTLNMVSSVMQPVVGWytdkrprPYALPIGLTASMLGILGLAFAPSFVTILCC 115
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIAtanyagyLVGALLASFLRRRGRA-------RRLIRGGLLLTVLLLAAMALTSGFAALLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 116 VFFIGLGSAI-FHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLGQFGAVWFTLvAALAVMFLLHIA 194
Cdd:cd06180 94 RFLAGAASAFvFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLAL-ALLSAVLLLLSF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 195 KWYAARLGSLAQKSGKQKKTSDNTAITKSVVSALIIIIFLIfarswytsAIGNFYTFYAMDTYHVSIQQAQsYIFVFLLF 274
Cdd:cd06180 173 LLLRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYI--------ITATFLPLIARETGAGSLLAGL-LWSLFGLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 275 GAVGTFLGGPLADRFGKRFVILGSLLCSApLAILLPFAGPVLAYGVL--ALIGLVLMSSFSVTVVYAQELVPGKIGTMSG 352
Cdd:cd06180 244 AVPSCFLWGALSDRWGTRRALAANLLVQA-VGVLLPLLSPGPAGLVLsaVLFGGTFMAITALVMALARELAPPAAPRALA 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1036601534 353 LTVgLAFGMGAIGAVALGALI--DTAGLTPTMIAIAFLPVLGILAFLLP 399
Cdd:cd06180 323 LMT-ASFGVGQILGPLLAGWLadATGGFAPALILAAAALVVAALLALLV 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
68-197 |
2.64e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 68 VSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSRVAYMAAG-TKRGLAQ 146
Cdd:cd17489 239 ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPpHRRGAAN 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1036601534 147 SIYQVGGNSGQAMAPLITALIlVPLGQFGAVWftLVAALAVMFLLHIAKWY 197
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLV-AELFGYRAMF--LLAAVVVLLALVLYIFL 366
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
252-398 |
3.49e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 252 YAMDTYHVSIQQAQSYIFVFLLFGAVGTFLGGPLADRFG-KRFVILGSLLCSAPLAILLPFAGPVLAYGVLALIGLVLMS 330
Cdd:cd06174 21 ALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGrRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGL 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1036601534 331 SFSVTVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd06174 101 IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAIL 168
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
74-399 |
4.70e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 74 PVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCVFFIGLGSAIFHPEGSRVAY-MAAGTKRGLAQSIYQVG 152
Cdd:cd17317 43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMeIVGPKYRSFVGILFGLF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 153 GNSGQAMAPLITALIlvplgqfgAVWFTLVAALAVMFLLHIAKWYaarlgslaqksgkqkKTSDNTAITKSVvsaliiii 232
Cdd:cd17317 123 WALGYMLLALLAYLI--------RDWRWLQLAISLPGLLFLLLLW---------------WLPRRTIIVGLI-------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 233 flifarsWYTSAIgnfyTFYAMdTYHVSIQQAQSYIfVFLLFGAV---GTFLGGPLADRFGKRFVILGSLLCS--APLAI 307
Cdd:cd17317 172 -------WFVTSL----VYYGL-SLNSSNLGGNLYL-NFFLSGLVeipAYFLALLLLDRLGRRWTLSGSLLLAglACLVT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 308 LLPFAGPVLAYGVLALIGLVLMS-SFSVTVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPtMIAIA 386
Cdd:cd17317 239 ALLPDDENTLALTLALVGKFAISaAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLP-LIIFG 317
|
330
....*....|....
gi 1036601534 387 FLPVL-GILAFLLP 399
Cdd:cd17317 318 VLALLgGLLTLLLP 331
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
270-398 |
5.82e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 270 VFLLFGAVGTFLGGPLADRFGKRFVILGS---LLCSAPLAILLPFAGPVLAYGVLALIGLVLMS-SFSVTVVYAQELVP- 344
Cdd:cd17357 57 IFFIGGAIGSFISAFLANRFGRKNGLLISnalLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGlSTGFVPMYLQEISPs 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1036601534 345 ---GKIGTMSGLTVGLAFGMGAIgaVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17357 137 elrGALGSLTQIGVTLGILLGQV--FGLPSVLGTETLWPYLLFFPGIPALLQLAALP 191
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
263-398 |
7.86e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.40 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 263 QAQSYIFVFLLFGAVGTFLGGPLADRFGKRFVILGSLLCS-APLAILLPFAGPVLAYGVLALIGLVLMSSFSvtVVYAqe 341
Cdd:PRK11551 256 QAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGIlASLAALAAAPSFAGMLLAGFAAGLFVVGGQS--VLYA-- 331
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036601534 342 LVPGKIGT-MSGLTVGLAFGMGAIGAVA---LGALIDTAGLTPTMIAIAFLPVL---GILAFLL 398
Cdd:PRK11551 332 LAPLFYPTqVRGTGVGAAVAVGRLGSMAgplLAGQLLALGRSTVGVIGASIPVIlvaALAALLL 395
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| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
37-398 |
9.98e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 37.64 E-value: 9.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 37 QAVIPAMFPILErSMSLSFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPIGLTASMLGILGLAFAPSFVTILCCV 116
Cdd:cd17312 20 KNFSVAKPPIVE-EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 117 FFIGL-GSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMAPLITALILVPLG----QFGAVWFTLVAALAVMFLL 191
Cdd:cd17312 99 GLNGLfQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGwraaFLVPGIVGLVVAIILFFFL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 192 H---IAKWYAArLGSLAQKSgkqkktsDNTAITksvvsaliiiiflifarSWYTsaignfytFYAMDTYHVSIQQAQSYI 268
Cdd:cd17312 179 RdspPYVWVLS-LAYAFVYI-------VRYACL-----------------DWGP--------LYLYEVKGYSLIDAGWFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036601534 269 FVFLLFGAVGTFLGGPLADRF--GKRFVILGSLLCSAPLAILLPFAGP---VLAYGVLALIGLVLMSSFSVTVVYAQELV 343
Cdd:cd17312 226 SLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPhnkLLSIVLLFLIGFFVGGPINLIGGAAAQDI 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1036601534 344 PGK--IGTMSGLTVGLAFGMGAIGAVALGALIDTAGLTPTMIAIAFLPVLGILAFLL 398
Cdd:cd17312 306 GRKeaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLS 362
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