|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
4-913 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1152.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:COG0495 7 PKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 84 SENYALKVKRHPAK--QAKIseKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:COG0495 86 AENAAIKNGVHPAEwtYENI--ANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKI 240
Cdd:COG0495 164 TVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDEKI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 241 KVFTTRPDTLFGATYMVLSPEHELIGKLESrIKNYQEVKKYIQKART------PAEDKEKTGVELkGIKAVNPANKEEIP 314
Cdd:COG0495 244 TVFTTRPDTLFGATFMVLAPEHPLVKELAT-PEQNAAVAAFIEEAKKkseierTSETKEKTGVFT-GLYAINPLTGEKIP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 315 IWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIPirsvlmgfdnihseelvslgikevwpadknhky 394
Cdd:COG0495 322 IWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD--------------------------------- 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 395 ieipenslpafeklirekmTPGFWNEyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpd 474
Cdd:COG0495 369 -------------------DPDILEE------------------------------------------------------ 375
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 475 vPFykelfihTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPV 550
Cdd:COG0495 376 -AY-------TGDGVLINSGEFDGLDSEEAKEAIIEWLEekglGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPV 447
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 551 PEQDLPVKLPYLKDwrPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARK 630
Cdd:COG0495 448 PEDQLPVELPEDVD--FDPTGGSPLARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANY 525
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 631 WLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGL---LIKDG------AKMSKSRGNVVSPDTYIK 701
Cdd:COG0495 526 WLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVSFDEPFKRLLTQGMvleVGKDGvviggiEKMSKSKGNVVDPDEIIE 605
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 702 KFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKKLASTSKEGLAENSE------RIVHQSIKKITEDIES 775
Cdd:COG0495 606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALKLDVADLSEadkelrRALHKTIKKVTEDIER 685
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 776 LRYNTAVSQLMILSNKLEELPK-------VPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAK 848
Cdd:COG0495 686 LRFNTAIAALMELVNALYKAKDsgeadraVLREALETLVLLLAPFAPHIAEELWERLG------HEGSVADAPWPEADEA 759
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 849 KIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYlLPG--LRKTIFVPDKLINFVV 913
Cdd:COG0495 760 ALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKF-LEGktIRKVIVVPGKLVNIVV 825
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
4-913 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 899.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:TIGR00396 3 HIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 84 SENYALKVKRHPAKQAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTV 163
Cdd:TIGR00396 82 AENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 164 LADEQVVS-GECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKIK 241
Cdd:TIGR00396 162 LANEQVDSdGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHDEKIT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 242 VFTTRPDTLFGATYMVLSPEHELIGKLesrIKNYQEVKKYIQKARTP------AEDKEKTGVELkGIKAVNPANKEEIPI 315
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLVEKA---AENNPKVAAFIKKILNKtvaertKATKEKKGVDT-GIKAIHPLTGEKIPI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 316 WVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRradipirsvlmgfdnihseelvslgikevwPADKNHKYI 395
Cdd:TIGR00396 318 WVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVID------------------------------PAEKDLSLT 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 396 Eipenslpafeklirekmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpdv 475
Cdd:TIGR00396 368 A------------------------------------------------------------------------------- 368
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 476 pfykelfIHTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPVP 551
Cdd:TIGR00396 369 -------AYTEDGVLVNSGEFNGLNSSEARNAIIDMLEkegkGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVP 441
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 552 EQDLPVKLPYLKDWRPKGTgvSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARKW 631
Cdd:TIGR00396 442 EEDLPVILPEDVVYDGDGG--SPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYW 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 632 LPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKF--------------------------------RAHGLL 679
Cdd:TIGR00396 520 LPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLinqgmvlgfyyppngkvpadvlterdekgkdkAGGELV 599
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 IKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKK---------LASTS 750
Cdd:TIGR00396 600 YVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEitgeldaasLTVTA 679
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 751 KEGLAENSERIVHQSIKKITEDIESLR-YNTAVSQLMILSNKLEELPK--VPWAAWEVFLKLLAPFAPYISEELYQKFGK 827
Cdd:TIGR00396 680 LEEAQKELRRDVHKFLKKVTEDLEKREsFNTAISAMMELLNKLYKAKKeaLMLEYLKGFVTVLSPFAPHLAEELWEKLGS 759
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 828 NKSfrkqnSVHLQSWPKYNAKKIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYLL-PGLRKTIFVPD 906
Cdd:TIGR00396 760 EPF-----IIDNAKWPVVDETALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLEnKTIKKVIYVPG 834
|
....*..
gi 1083487655 907 KLINFVV 913
Cdd:TIGR00396 835 KLVNFVI 841
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
4-913 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 797.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 4 FSRIEKKWNALWRKTGVFE-PELGRAKKP-FYNLMMFPYPSAEGLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFG 81
Cdd:PLN02563 82 FHEIEPKWQRYWEENRTFRtPDDVDTSKPkFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 82 IHSENYALKVKRHPAKQAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:PLN02563 162 LPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALG 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKIDWSEKVKIAQRNWIGRSEGVEIEFKI-----QNS 236
Cdd:PLN02563 242 TVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVldgegKER 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 237 NLKIKVFTTRPDTLFGATYMVLSPEHELIGKLESRIKNyQEVKKYIQKA-------RTPAEdKEKTGVeLKGIKAVNPAN 309
Cdd:PLN02563 322 DEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQK-EAVEEYVDAAsrksdleRTELQ-KEKTGV-FTGSYAINPAT 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 310 KEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIpirsvlmgfdnihseelvslgikEVWPAD 389
Cdd:PLN02563 399 GEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADG-----------------------NEDDAE 455
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 390 Knhkyieipenslpafeklirekmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvw 469
Cdd:PLN02563 456 K------------------------------------------------------------------------------- 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 470 nwlpdvpfykelfIHTERGILINSA----KFSGMDSEEAKWEITKFV----GGERKVQYRLRDWLISRQRYWGPPIPMIF 541
Cdd:PLN02563 457 -------------AYTGEGVIVNSSssglDINGLSSKEAAKKVIEWLeetgNGKKKVNYKLRDWLFARQRYWGEPIPVVF 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 542 CEKCNWQ-PVPEQDLPVKLPYLKDWRPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKK 620
Cdd:PLN02563 524 LEDSGEPvPVPESDLPLTLPELDDFTPTGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSN 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 621 EIFSKALARKWLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGLL--------------------- 679
Cdd:PLN02563 604 ALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMIlgeveytafkdsdgeyvsadt 683
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 -----------------IKDGA-----------------KMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFR 725
Cdd:PLN02563 684 adrlgelqqekipeekvIKSGDsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWS 763
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 726 DSGILGITRFLARV----------QKFEKKLASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEEL 795
Cdd:PLN02563 764 TSGVEGVHRFLGRTwrlvvgaplpDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKW 843
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 796 PKVPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAKKIKEDVFLLVVQVNGKVRATIQAPVGI 875
Cdd:PLN02563 844 DKVPREAIEPFVLLLSPYAPHLAEELWFRLG------HSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGC 917
|
970 980 990
....*....|....*....|....*....|....*....
gi 1083487655 876 SEKDAERIALANENVKKYLL-PGLRKTIFVPDKLINFVV 913
Cdd:PLN02563 918 SEDDAFALASQDEKLSKYLDgKEIKKRIYVPGKILNVIL 956
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
218-359 |
1.03e-72 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 237.06 E-value: 1.03e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 218 RNWIGRSEGVEIEFKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHELIGKLEsriKNYQEVKKYIQKARTP------AED 291
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLA---EKNPEVAAFIEECKNTseiertSET 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1083487655 292 KEKTGVeLKGIKAVNPANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAD 359
Cdd:pfam13603 78 KEKEGV-FTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPED 144
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
4-866 |
5.18e-67 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 240.73 E-value: 5.18e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 4 FSRIEKKWNALWRKTGVFEPELGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGI 82
Cdd:TIGR00422 7 PHEVEKKWYKKWEKSGFFKPDGNSNKPPF--CIDIPPPNVTGsLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 83 HSENyalKVKRHPAKQAK----ISEKNFYR---------------QLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFK 143
Cdd:TIGR00422 85 ATQV---KVEKKLGAEGKtkhdLGREEFREkiwewkeesggtiknQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 144 KGLAYRKKQAVNWCPDCKTVLADEQVvsgecerceskvIKKELEQ--WFFRitnyaerllkdlekidwsekvkiaqrnwi 221
Cdd:TIGR00422 162 KGLIYRGEYLVNWDPKLNTAISDIEV------------EYKEVKGklYYIR----------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 222 grsegveieFKIQN-SNLKIKVFTTRPDTLFGATYMVLSPE----HELIGKlesriknyqevkkyiqkartpaedkektg 296
Cdd:TIGR00422 201 ---------YPLANgSKDYLVVATTRPETMFGDTAVAVHPEderyKHLIGK----------------------------- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 297 velkgiKAVNPANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAdipirsvlmGFDNIHSEE 376
Cdd:TIGR00422 243 ------KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED---------GLLNENAGK 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 377 LVSLGIKEvwpadknhkyieipenslpAFEKLIREKMTPGFWNEYITH-QRVIFIFKDKNgLVERLeLTPgtdnkinrls 455
Cdd:TIGR00422 308 YQGLTRFE-------------------ARKKIVEDLKEEGLLVKIEPHtHNVGTCWRSGT-VVEPL-LSK---------- 356
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 456 aiynnepepkgsvwNWLPDVPfykelfihtergILINSAKfsgmdsEEAKWEITKFVGGERKVQYR-----LRDWLISRQ 530
Cdd:TIGR00422 357 --------------QWFVKVE------------KLADKAL------EAAEEGEIKFVPKRMEKRYLnwlrnIKDWCISRQ 404
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 531 RYWGPPIPMIFCEKCNWQPVPEQDLPVKLPYLkdwrpkgtgvsplaseskfykvkcPKCNGEARRETDVSDTFLDSAWYF 610
Cdd:TIGR00422 405 LIWGHRIPVWYCKECGEVYVAKEEPLPDDKTN------------------------TGPSVELEQDTDVLDTWFSSSLWP 460
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 611 FRYLDVKNKKEIFskalaRKWLPVDMYIGGaeHAVLHLLYVRFITKVFADLGLVgfrePSKKFRAHGLLI-KDGAKMSKS 689
Cdd:TIGR00422 461 FSTLGWPDETKDL-----KKFYPTDLLVTG--YDIIFFWVARMIFRSLALTGQV----PFKEVYIHGLVRdEQGRKMSKS 529
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 690 RGNVVSPDTYIKKFGADALRMYLMFLGPfdQGGDFR------DSG------ILGITRFLARVQKFEKKLASTskEGLAEN 757
Cdd:TIGR00422 530 LGNVIDPLDVIEKYGADALRFTLASLVT--PGDDINfdwkrvESArnflnkLWNASRFVLMNLSDDLELSGG--EEKLSL 605
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 758 SER-IVH---QSIKKITEDIESLRYNTAVSQLM------------------ILSNKLEELPKVPWAAWEVF---LKLLAP 812
Cdd:TIGR00422 606 ADRwILSklnRTIKEVRKALDKYRFAEAAKALYefiwndfcdwyielvkyrLYNGNEAEKKAARDTLYYVLdkaLRLLHP 685
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 813 FAPYISEELYQKFGKnksfrKQNSVHLQSWPKYNAKKIKEDV---FLLVVQVNGKVR 866
Cdd:TIGR00422 686 FMPFITEEIWQHFKE-----GADSIMLQSYPVVDAEFVDEEAekaFELLKEIIVSIR 737
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
7-866 |
9.44e-59 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 215.83 E-value: 9.44e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 7 IEKKWNALWRKTGVFEPELGRAKK-------PfynlmmfPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDG 79
Cdd:PRK13208 15 LEEKWQKIWEEEGTYKFDPDERKPvysidtpP-------PTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 80 FGIHSE----NYaLKVKRHPAKQAK----------ISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKG 145
Cdd:PRK13208 87 NGLPTErkveKY-YGIRKDDISREEfielcreltdEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 146 LAYRKKQAVNWCPDCKTVLADeqvvsGECERceskvikKELEQWFFRItnyaerllkdlekidwseKVKIAQrnwigrSE 225
Cdd:PRK13208 166 LIYRAEAPVLWCPRCETAIAQ-----AEVEY-------REREGKLNYI------------------KFPVED------GE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 226 GVEIEfkiqnsnlkikvfTTRPDtLFGATY-MVLSPEHE----LIGKlesriknyqevkkyiqKARTPAEDKEktgVELK 300
Cdd:PRK13208 210 EIEIA-------------TTRPE-LLPACVaVVVHPDDErykhLVGK----------------TAIVPLFGVE---VPIL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 301 GIKAVNPaNKeeipiwvadyvlggvGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAdipirsvlmGFDNIHSEELVSL 380
Cdd:PRK13208 257 ADPLVDP-DF---------------GTGAVMICTFGDKTDVTWWRELNLPTRIIIDED---------GRMTEAAGKLAGL 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 381 GIKEvwpADKnhKYIEIpensLPAFEKLIREK----MTPGFWN-----EYITHqRVIFI----FKDKngLVERLeltpgt 447
Cdd:PRK13208 312 TIEE---ARK--KIVED----LKSGGLLGKQEpikhNVKFCERcdtplEILVT-RQWFIkvldLKEE--LLERG------ 373
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 448 dNKInrlsaiynnepepkgsvwNWLPDvpFYKElfihtergILINSAKfsGMDseeakWeitkfvggerkvqyrlrDWLI 527
Cdd:PRK13208 374 -KEI------------------NWYPE--HMRV--------RLENWIE--GLN-----W-----------------DWCI 400
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 528 SRQRYWGPPIPMIFCEKCNwQPVP--EQDLPVKlpylkdwrpkgtgvsPLASESKFYkvKCPKCN-GEARRETDVSDTFL 604
Cdd:PRK13208 401 SRQRYFGTPIPVWYCKDCG-HPILpdEEDLPVD---------------PTKDEPPGY--KCPQCGsPGFEGETDVMDTWA 462
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 605 DSA--------WyffrYLDVKNKKEIFSKALA-------RKWLpvdmyiggaehavlhllyvrFITKVFADLgLVGfREP 669
Cdd:PRK13208 463 TSSitplivtgW----ERDEDLFEKVFPMDLRpqghdiiRTWL--------------------FYTILRAYL-LTG-KLP 516
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 670 SKKFRAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRmYLMFLGPfdQGGDFR-DSGILGITRFLAR----VQKFE 743
Cdd:PRK13208 517 WKNIMISGMvLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YWAASAR--LGSDTPfDEKQVKIGRRLLTklwnASRFV 593
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 744 KKLASTSKEGLAENSERI-------VHQSIKKITEDIESLRYNTAVSQL--------------MI---LSNKLEELPKVp 799
Cdd:PRK13208 594 LHFSADPEPDKAEVLEPLdrwilakLAKVVEKATEALENYDFAKALEEIesffwhvfcddyleLVksrAYGEDEEEEQK- 672
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 800 wAAW-------EVFLKLLAPFAPYISEELYQKFGKnksfrkqNSVHLQSWPKYNAKKIKED---VFLLVVQVNGKVR 866
Cdd:PRK13208 673 -SARytlytvlDTLLRLLAPFLPFITEEVWSWLYG-------GSVHRASWPEPDEELIDEEdeeLGELAKEILSAVR 741
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
32-222 |
2.12e-52 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 185.91 E-value: 2.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 32 FYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQAKISEKNFYRQLG 111
Cdd:cd00812 2 FYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 112 MIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCpdcktvladeqvvsgecerceskvikKELEQWFF 191
Cdd:cd00812 81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
|
170 180 190
....*....|....*....|....*....|....
gi 1083487655 192 RI--TNYAERLLKDLEKID-WSEKVKIAQRNWIG 222
Cdd:cd00812 135 KYseTEWKEKLLKDLEKLDgWPEEVRAMQENWIG 168
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
10-712 |
2.40e-49 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 184.92 E-value: 2.40e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 10 KWNALWRKTGVFEPELGRAK-KPFYNLMMFPyPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSE-- 85
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKgKPSFTIHDGP-PNATGsLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEqv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 86 -------------------NYALKVKRHPAKQAKISEKNFYRqlgmIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGL 146
Cdd:pfam00133 80 vekklgikekktrhkygreEFREKCREWKMEYADEIRKQFRR----LGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 147 AYRKKQAVNWCPDCKTVLADEQVvsgecercESKVIKKELeqWFFRITnyaerlLKDLEKIdwsekvkiaqrnwigrseg 226
Cdd:pfam00133 156 IYRGKKLVNWSPALNTALSNLEV--------EYKDVKGPS--IHVAFP------LADDEGA------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 227 veiefkiqnsnlKIKVFTTRPDTLFGATYMVLSPEHELIGKLESRIKNYQEVKKYIQKARTPAEDKEKTGVELKGIKAVN 306
Cdd:pfam00133 201 ------------SLVIWTTTPWTLPGNTAVAVNPEFDYVITGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIH 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 307 PANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLP-IKPVirradipirsvlmGFDNIHSEELVSLGIKEV 385
Cdd:pfam00133 269 PFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEvINPV-------------DDDGTFTEEAPDFQGVYR 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 386 WPADKnhKYIEIPENsLPAFEKLIREKMTPGF-WNE------YITHQRVIFIFKDKNGLVERLELTpgtdnkinrlsaiy 458
Cdd:pfam00133 336 FDARK--KIVELLTE-KGLLLKIEPFTHSYPFcWRSgtpiipRATPQWFVRMDELADQALEAVEKV-------------- 398
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 459 nnepepkgsvwNWLPDvpFYKELFIHTERGIlinsakfsgmdseeakweitkfvggerkvqyrlRDWLISRQRYWGPPIP 538
Cdd:pfam00133 399 -----------QFVPK--SGEKRYFNWLANI---------------------------------QDWCISRQRWWGHPIP 432
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 539 MifcekcnWQPVPEQDLPVKLPYLKDWRPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLD--V 616
Cdd:pfam00133 433 A-------WVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKDKLGYGKGTLEQDEDVLDTWFSSGSWPFSTLGwpF 505
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 617 KNKKEIfskalaRKWLPVDMYIGGAEhavlhLLYVRFITKVFADLGLVGfREPSKKFRAHGLLI-KDGAKMSKSRGNVVS 695
Cdd:pfam00133 506 VNTEEF------KKFFPADMLLEGSD-----QTRGWFYRMIMLSTALTG-SVPFKNVLVHGLVRdEQGRKMSKSLGNVID 573
|
730
....*....|....*..
gi 1083487655 696 PDTYIKKFGADALRMYL 712
Cdd:pfam00133 574 PLDVIDKYGADALRLWL 590
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
522-724 |
2.03e-47 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 171.66 E-value: 2.03e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 LRDWL-ISRQRYWGPPIPMifcekcnwqpvpeqdlpvklpylkdwrpkgtgvsplaseskfykvkcpkcngearreTDVS 600
Cdd:cd00812 163 QENWIgCSRQRYWGTPIPW---------------------------------------------------------TDTM 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 601 DTFLDSAWYFFRYLDVKN------KKEIFSKALARKWLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVgFREPSKKFR 674
Cdd:cd00812 186 ESLSDSTWYYARYTDAHNleqpyeGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLI 264
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1083487655 675 AHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF 724
Cdd:cd00812 265 VQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
4-873 |
4.60e-46 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 178.34 E-value: 4.60e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 4 FSRIEKKWNALWRKTGVFEPELGRAK-KPFYNLMMFPyPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLD--- 78
Cdd:TIGR00392 8 LSKREEKILAFWQENDIFEKVKKLNKgKPEFIFHDGP-PYANGsIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDthg 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 79 ---------GFGIHS---------ENYALKVKRHPAKQAKISEKNFYRqLGMIGNgfaWKEKLETYDPEYYKWTQWIFVQ 140
Cdd:TIGR00392 87 lpiehkvekKLGISGkkeissleiEEFREKCREFALKQIEEQREQFQR-LGVWGD---WENPYKTMDPSYEESQWWLFKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 141 MFKKGLAYRKKQAVNWCPDCKTVLADEQVVSGECERCEskvikkeleqwffritnyaerllkdlekidwsekvkiaqrnw 220
Cdd:TIGR00392 163 AHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYKDV------------------------------------------ 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 221 igRSEGVEIEFKIQNSNLK--------IKVFTTRPDTLFGATYMVLSPEHE-----LIGKLESRIKNYQEVKKYIQKART 287
Cdd:TIGR00392 201 --KDPSIYVKFPVKKDKKTylkvklssLLIWTTTPWTLPSNLAIAVHPDFEyalvqDNTKVEYFILAKKLVEKLYNKAGS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 288 PAEDKEK-TGVELKGIKAVNPAN------KEEIPIWV-ADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIkpvirrad 359
Cdd:TIGR00392 279 DYEIIKTfKGSDLEGLEYEHPLYdfvsqlKEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEV-------- 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 360 ipirsvLMGFD--NIHSEELVSLGIKEVWPADKNhkyieipensLPAFEKLIREKMtpgfwneyithqrvififKDKNGL 437
Cdd:TIGR00392 351 ------LSPVDekGVYTEGVNDFQGRFVKDADKD----------IIKANKIIIEQL------------------KDKGLL 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 438 VerleltpgtdnkinRLSAIYNNEPepkgsvWNWLPDVP--FY--KELFIHTE--RGILINSAKFSGMDSEEAKWEITKF 511
Cdd:TIGR00392 397 L--------------KAEKITHSYP------HCWRTKTPviYRatEQWFIKTKdiKDQMLEQIKKVNWVPEWGEGRFGNW 456
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 512 VGGerkvqyrLRDWLISRQRYWGPPIPMIFCEKCNwQP-----VPEQDLPVKLPYLKDWRPKgtGVSPLASESKFykvKC 586
Cdd:TIGR00392 457 LEN-------RPDWCISRQRYWGIPIPIWYCEDTG-EPivvgsIEELIELIELKGIDAWFED--LHRDFLDKITL---KS 523
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 587 PKCnGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFskalaRKWLPVDMYIGGAEHA-----VLHLLYVRFITKVfadl 661
Cdd:TIGR00392 524 GDG-GEYRRVPDVLDVWFDSGSMPYASIHYPFENEKF-----KEVFPADFILEGSDQTrgwfySSLAIGTALFGQA---- 593
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 662 glvgfrePSKKFRAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGP-----FDQGG--DFRDS--GILG 731
Cdd:TIGR00392 594 -------PYKNVITHGFtLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSDPwedlrFSDEIlkQVVEKyrKIRW 666
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 732 IT-RFL---ARVQKFEKKLASTSKEGLAENSERIVHQS---IKKITEDIESLRYNTAVSQLM-----ILSNKLEELPK-- 797
Cdd:TIGR00392 667 NTyRFLltyANLDKFDPLFNSVAVEKFPEEDRWILSRLnslVEEVNEALEKYNFHKVLRALQdfiveELSNWYIRIIRdr 746
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 798 ---------------VPWAAWEVFLKLLAPFAPYISEELYQ--KFGKNKSfrkqnSVHLQSWPKYNAK----------KI 850
Cdd:TIGR00392 747 lyceakdndkraaqtTLYYALLTLVRLLAPFLPHTAEEIYQnlPGGEEEE-----SVHLNLWPEVDEEfidealeanmAI 821
|
970 980
....*....|....*....|...
gi 1083487655 851 KEDVFLLVVQVNGKVRATIQAPV 873
Cdd:TIGR00392 822 VREIVEAFLALRDAANKKLRQPL 844
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
2-853 |
1.46e-42 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 167.95 E-value: 1.46e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 2 AGFSRIEKKWNALWRKTGVFEP--ELGRAKKPFYnlmmF---PyPSAEGL-HVGnmYAFVGS--DIYGRFQRMRGNDVFE 73
Cdd:COG0060 16 ANLPKREPEILKFWEENDIYEKsrEARAGRPKFV----LhdgP-PYANGDiHIG--HALNKIlkDIIVRYKTMRGFDVPY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 74 ---------PI--------GLDGFGIHS----------ENYALKvkrhpakQAKISEKNFYRqLGMIGNgfaWKEKLETY 126
Cdd:COG0060 89 vpgwdchglPIelkvekelGIKKKDIEKvgiaefrekcREYALK-------YVDEQREDFKR-LGVWGD---WDNPYLTM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 127 DPEYYK--WtqWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEqvvsgecerceskvikkELEqwffritnYAER----- 199
Cdd:COG0060 158 DPEYEEsiW--WALKKLYEKGLLYKGLKPVPWCPRCGTALAEA-----------------EVE--------YKDVtspsi 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 200 ----LLKDLEKIDWSEKVKIAqrnwigrsegveiefkiqnsnlkikVFTTRPDTLFG------------ATYMVLSPEH- 262
Cdd:COG0060 211 yvkfPVKDEKALLLLEDAYLV-------------------------IWTTTPWTLPAnlavavhpdidyVLVEVTGGERl 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 263 ----ELIGKL--ESRIKNYQEVKKYiqkartpaedkekTGVELKGIKAVNP-----ANKEEIPIWVADYVLGGVGTGAI- 330
Cdd:COG0060 266 ilaeALVEAVlkELGIEDYEVLATF-------------KGAELEGLRYEHPfyyvvGYDRAHPVILGDYVTTEDGTGIVh 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 331 MAvPAHDERDFEFAKKFKLPIKPVIR-----RADIPirsvlmGFDNIHseelvslgikeVWPADKnhkyiEIPENsLPAF 405
Cdd:COG0060 333 TA-PGHGEDDFEVGKKYGLPVLNPVDddgrfTEEAP------LFAGLF-----------VKDANP-----AIIED-LKER 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 406 EKLIREKMtpgfwneyITHQ-----R----VI-------FI----FKDKnglverleltpgtdnkinrlsAIYNNEpepk 465
Cdd:COG0060 389 GALLAREK--------ITHSyphcwRcktpLIyratpqwFIsmdkLRDR---------------------ALEAIE---- 435
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 466 gSVwNWLPDvpfYKElfihtERgilinsakfsgmdseeakweITKFVGGerkvqyrLRDWLISRQRYWGPPIPMIFCEKC 545
Cdd:COG0060 436 -KV-NWIPE---WGE-----GR--------------------FGNMLEN-------RPDWCISRQRYWGVPIPIWVCEDC 478
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 546 NWQPVPE------------------QDLPVKLPYLKDwrpkgtgvsplaseskfyKVKCPKCNGEARRETDVSDTFLDS- 606
Cdd:COG0060 479 GELHRTEevigsvaelleeegadawFELDLHRPFLDE------------------TLKCPKCGGTMRRVPDVLDVWFDSg 540
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 607 -AWYFfrylDVKNKKEifskalarKWLPVDMYI-GGAEHA----VLHLLYVrfitkvfadlGLVGfREPSKKFRAHGL-L 679
Cdd:COG0060 541 sMHFA----VLENREE--------LHFPADFYLeGSDQTRgwfySSLLTST----------ALFG-RAPYKNVLTHGFvL 597
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 IKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLgpfDQGGDFR-DSGILGITR------------FLARVQKFEKKL 746
Cdd:COG0060 598 DEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASS---DYWGDLRfSDEILKEVRdvyrrlrntyrfLLANLDDFDPAE 674
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 747 ASTSKEGLAEnSER-IVH---QSIKKITEDIESLRYNTAVSQLMI-----LSN-------------KLEELPKVpwAA-- 802
Cdd:COG0060 675 DAVPYEDLPE-LDRwILSrlnELIKEVTEAYDNYDFHRAYRALHNfcvedLSNwyldiskdrlyteAADSLDRR--AAqt 751
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*.
gi 1083487655 803 --WEVF---LKLLAPFAPYISEELYQKFGKNKSfrkqNSVHLQSWPKYNAKKIKED 853
Cdd:COG0060 752 tlYEVLetlVRLLAPILPFTAEEIWQNLPGEAE----ESVHLADWPEVDEELIDEE 803
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
7-896 |
2.00e-36 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 148.99 E-value: 2.00e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 7 IEKKWNALWRKTGVFE-PELGRAKKPFYnlMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRG-NDVFEPiGLDGFGIH 83
Cdd:PRK14900 24 VEARWYPFWQERGYFHgDEHDRTRPPFS--IVLPPPNVTGsLHLGHALTATLQDVLIRWKRMSGfNTLWLP-GTDHAGIA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 84 SEnyaLKVKRHPAKQAKISEKNFYRQlGMIGNGFAWKEKLE---------------------TYDPEYYKWTQWIFVQMF 142
Cdd:PRK14900 101 TQ---MIVEKELKKTEKKSRHDLGRE-AFLERVWAWKEQYGsrigeqhkalgasldwqrerfTMDEGLSRAVREVFVRLH 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 143 KKGLAYRKKQAVNWCPDCKTVLADEQVVSGECerceskvikKELEQWFFRitnyaerllkdlekidwsekvkiaqrnwig 222
Cdd:PRK14900 177 EEGLIYREKKLINWCPDCRTALSDLEVEHEEA---------HQGELWSFA------------------------------ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 223 rsegveieFKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHEligklesrikNYQevkkyiqkartpaedkektgvELKGI 302
Cdd:PRK14900 218 --------YPLADGSGEIVVATTRPETMLGDTAVAVHPLDP----------RYM---------------------ALHGK 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 303 KAVNPANKEEIPIwVADYVL--GGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIrradipirsvlmGFDNIHSEELVSL 380
Cdd:PRK14900 259 KVRHPITGRTFPI-VADAILvdPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVI------------GPDGRMTAEAGPL 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 381 GIKEVWPADKNHKYIeIPENSLPAFEKliREKMTPGfwneyiTHQRVIFIFkdknglverleltpgtdnkinrlsaiynn 460
Cdd:PRK14900 326 AGLDRFEARKEVKRL-LAEQGLDRGAK--PHVLPLG------RCQRSATIL----------------------------- 367
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 461 epEPKGSVWNWLPDVPFYKELFIHTERGilinsakfsgmdseeakweITKFVGGERKVQY-----RLRDWLISRQRYWGP 535
Cdd:PRK14900 368 --EPLLSDQWYVRIEPLARPAIEAVEQG-------------------RTRFIPEQWTNTYmawmrNIHDWCISRQLWWGH 426
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 536 PIPMIFCekcnwqpvpeqdlPVKLPYLKDWRPKGtgvsplaseskfykvkCPKCNG-EARRETDVSDTFLDSAWYFFRYL 614
Cdd:PRK14900 427 QIPAWYC-------------PDGHVTVARETPEA----------------CSTCGKaELRQDEDVLDTWFSSGLWPFSTM 477
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 615 D-VKNKKEIfskalaRKWLPVDMYIGGaeHAVLHLLYVRFITKVFADLGLVGFRepskKFRAHGlLIKD--GAKMSKSRG 691
Cdd:PRK14900 478 GwPEQTDTL------RTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEVPFR----TVYLHP-MVRDekGQKMSKTKG 544
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 692 NVVSPDTYIKKFGADALRMYLMFLGPfdQGGDFRDS------------GILGITRF-LARVQKFEKKLASTSKEGLAENS 758
Cdd:PRK14900 545 NVIDPLVITEQYGADALRFTLAALTA--QGRDIKLAkeriegyrafanKLWNASRFaLMNLSGYQERGEDPARLARTPAD 622
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 759 ERIVHQSIKKITEDIESL---RYNTAVSQLMI-----LSNKLEELPKVPWA----------------AWEVFLKLLAPFA 814
Cdd:PRK14900 623 RWILARLQRAVNETVEALeafRFNDAANAVYAfvwheLCDWYIELAKEALAsedpearrsvqavlvhCLQTSYRLLHPFM 702
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 815 PYISEELYQKFGKNKSFRK-QNSVHLQSWPKYNA-KKIKEDVFLLVV-------------QVNGKVRATIQAPVGISEKD 879
Cdd:PRK14900 703 PFITEELWHVLRAQVGASAwADSVLAAEYPRKGEaDEAAEAAFRPVLgiidavrnirgemGIPWKVKLGAQAPVEIAVAD 782
|
970
....*....|....*..
gi 1083487655 880 AERIALANENVKKYLLP 896
Cdd:PRK14900 783 PALRDLLQAGELARVHR 799
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
46-854 |
5.02e-36 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 147.32 E-value: 5.02e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 46 LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGldgF--------GIhsenyALKVKRHPAKQAKISeKNFY---------- 107
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMA---FhvtgtpilGI-----AERIARGDPETIELY-KSLYgipeeelekf 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 108 ---------------RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVSG 172
Cdd:PRK12300 72 kdpeyiveyfseeakEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 173 EcerceskviKKELEQWffritnyaerllkdlekidwsekvkiaqrnwigrsegVEIEFKiQNSNLKIKVFTTRPDTLFG 252
Cdd:PRK12300 152 E---------EPEIVEY-------------------------------------TLIKFE-ESEDLILPAATLRPETIFG 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 253 ATYMVLSPEHE-LIGKLESR--IKNYQEVKKYIQKARTPAEDKEKTGVELKGIKAVNPANKEEIPIWVADYVLGGVGTGA 329
Cdd:PRK12300 185 VTNLWVNPDATyVKAEVDGEkwIVSKEAAEKLSFQDRDVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGV 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 330 IMAVPAHDE------RDFEFAKKFKLPIKPvirradIPIRSVlMGFDNIHSEELV-SLGIKEvwPADknhkyieipensl 402
Cdd:PRK12300 265 VMSVPAHAPydyvalRDLKKNKELLDVIEP------IPLIEV-EGYGEFPAKEVVeKLGIKS--QED------------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 403 PAFEKLIREkmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaIYNNEpepkgsvwnwlpdvpFYKelf 482
Cdd:PRK12300 323 PELEEATKE---------------------------------------------VYRAE---------------FHK--- 339
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 483 ihterGILI-NSAKFSGMDSEEAKWEITKF-----VGG------ERKVQYR---------LRD-WLIsrqRYwGPPIPMI 540
Cdd:PRK12300 340 -----GVLKeNTGEYAGKPVREAREKITKDliekgIADimyefsNRPVYCRcgtecvvkvVKDqWFI---DY-SDPEWKE 410
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 541 FCEKC--NWQPVPE---QDLPVKLPYLKDW---RPKGTG----------VSPLaSESKFY--------KVKCPKCNGEar 594
Cdd:PRK12300 411 LAHKAldNMEIIPEeyrKEFENTIDWLKDRacaRRRGLGtrlpwdeewiIESL-SDSTIYmayytiahKIREYGIKPE-- 487
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 595 retDVSDTFLDsawYFFryLDVKNKKEIFSKAL--------ARK----WLPVDMYIGGAEHAVLHLLYvrFItkvFADLG 662
Cdd:PRK12300 488 ---QLTPEFFD---YVF--LGKGDPEEVSKKTGipkeileeMREeflyWYPVDWRHSGKDLIPNHLTF--FI---FNHVA 554
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 663 LvgFREpSKKFRA---HGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARV 739
Cdd:PRK12300 555 I--FPE-EKWPRGivvNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERF 631
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 740 QKFEKKLASTSKEGLAENSER----IVHQSIKKITEDIESLRYNTAVsQLMI--LSNKL--------EELPKVPWAAWEV 805
Cdd:PRK12300 632 YELAKELIEIGGEEELRFIDKwllsRLNRIIKETTEAMESFQTRDAV-QEAFyeLLNDLrwylrrvgEANNKVLREVLEI 710
|
890 900 910 920
....*....|....*....|....*....|....*....|....*....
gi 1083487655 806 FLKLLAPFAPYISEELYQKFGKnKSFrkqnsVHLQSWPKYNAKKIKEDV 854
Cdd:PRK12300 711 WIRLLAPFTPHLAEELWHKLGG-EGF-----VSLEKWPEPDESKIDEEA 753
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
7-889 |
8.25e-36 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 146.40 E-value: 8.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 7 IEKKWNALWRKTGVFEPElGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDV-FEPiGLDGFGIHS 84
Cdd:PRK05729 14 VEAKWYQKWEEKGYFKPD-DNSKKPF--SIVIPPPNVTGsLHMGHALNNTLQDILIRYKRMQGYNTlWLP-GTDHAGIAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 85 ENyalKVKRHPAKQ-------------AKISE-KNFY-----RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKG 145
Cdd:PRK05729 90 QM---VVERQLAAEgksrhdlgrekflEKVWEwKEESggtitNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 146 LAYRKKQAVNWCPDCKTVLADEQVvsgecercESKVIKKELeqWFFRitnYaerllkdlekidwsekvkiaqrnwigrse 225
Cdd:PRK05729 167 LIYRGKRLVNWDPKLQTALSDLEV--------EYKEVKGKL--WHIR---Y----------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 226 gveiefKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHE----LIGKlesriknyqevkkyiqkartpaedkektgvelkg 301
Cdd:PRK05729 205 ------PLADGSDYLVVATTRPETMLGDTAVAVNPEDErykhLIGK---------------------------------- 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 302 iKAVNPANKEEIPIwVAD-YVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVI-RRADIpirsvlmgfdNIHSEELVS 379
Cdd:PRK05729 245 -TVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMdEDGTI----------NENPGEYQG 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 380 LgikevwpaDKnhkyieipenslpaFE--KLIREKMtpgfwneyithqrvififkDKNGLVERLEltpgtDNKIN----- 452
Cdd:PRK05729 313 L--------DR--------------FEarKAIVADL-------------------EELGLLVKIE-----PHTHSvghsd 346
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 453 --------RLS-------------AIYNNEpepKGsvwnwlpDVPFYKELFIHTERGILINsakfsgmdseeakweitkf 511
Cdd:PRK05729 347 rsgvviepYLSdqwfvkmkplakpALEAVE---NG-------EIKFVPERWEKTYFHWMEN------------------- 397
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 512 vggerkvqyrLRDWLISRQRYWGPPIPMIFCEKCNWQpVPEQDlpvklpylkdwrpkgtgvsplaseskfykvkcPKCNG 591
Cdd:PRK05729 398 ----------IQDWCISRQLWWGHRIPAWYDEDGEVY-VGREE--------------------------------PEARE 434
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 592 EA--RRETDVSDTfldsaWyffryldvknkkeiFSKALA--------------RKWLPVD---------------MYIGG 640
Cdd:PRK05729 435 KAllTQDEDVLDT-----W--------------FSSALWpfstlgwpektedlKRFYPTSvlvtgfdiiffwvarMIMMG 495
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 641 aehavLHllyvrFITKV-FADLGLvgfrepskkfraHGlLIKD--GAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGP 717
Cdd:PRK05729 496 -----LH-----FTGQVpFKDVYI------------HG-LVRDeqGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALAS 552
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 718 fdQGGDFR------DSG------ILGITRFlARVQKFEKKLASTSKEGLAENSER-IVH---QSIKKITEDIESLRYNTA 781
Cdd:PRK05729 553 --PGRDIRfdeervEGYrnfankLWNASRF-VLMNLEGADVGELPDPEELSLADRwILSrlnRTVAEVTEALDKYRFDEA 629
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 782 VSQL--------------MI---LSNKLEELPK-VPWAAWEVFLKLLAPFAPYISEELYQKFgknKSFRKQNSVHLQSWP 843
Cdd:PRK05729 630 ARALyefiwnefcdwyleLAkpvLQEAAKRATRaTLAYVLEQILRLLHPFMPFITEELWQKL---APLGIEESIMLAPWP 706
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 844 KYNAKKIKEDV--FLLVVQVNGKVR---------ATIQAPVGISEKDAERIALANEN 889
Cdd:PRK05729 707 EADEAIDEAAEaeFEWLKELITAIRniraemnipPSKKLPLLLKGADAEDRARLEAN 763
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
7-889 |
4.79e-33 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 137.49 E-value: 4.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 7 IEKKWNALWRKTGVFEPELGRAKKPFYnlMMFPYPSAEG-LHVGnmYAFVGS--DIYGRFQRMRGNDV-FEPiGLDGFGI 82
Cdd:COG0525 12 VEAKWYQYWEENGYFKADPDSDKEPFT--IVIPPPNVTGsLHMG--HALNNTlqDILIRYKRMQGYNTlWQP-GTDHAGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 83 HSENyalKVKRHPAKQ-------------AKISE-KNFY-----RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFK 143
Cdd:COG0525 87 ATQA---VVERQLAEEgksrhdlgrekflERVWEwKEESggtitNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 144 KGLAYRKKQAVNWCPDCKTVLADEQVvsgecercESKVIKKELeqWFFRitnYaerllkdlekidwsekvkiaqrnwigr 223
Cdd:COG0525 164 KGLIYRGKRLVNWDPKLKTALSDLEV--------EHEEVKGHL--WHIR---Y--------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 224 segveiefKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHE----LIGKlesriknyqevkkyiqkartpaedkektgvel 299
Cdd:COG0525 204 --------PLADGSGYIVVATTRPETMLGDTAVAVHPEDErykhLIGK-------------------------------- 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 300 kgiKAVNPANKEEIPIwVAD-YVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIkpvirradIPIrsvlMGFD---NIHSE 375
Cdd:COG0525 244 ---TVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM--------INI----LDEDgtiNENAG 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 376 ELVslGikevwpadknhkyieipensLPAFE--KLIREKMtpgfwneyithqrvififkDKNGLVERLEltpgtDNKIN- 452
Cdd:COG0525 308 KYR--G--------------------LDRFEarKAIVADL-------------------EELGLLVKVE-----PHKHSv 341
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 453 ----RLSAIYnnepEPkgsvwnWLPDVPF--YKELfihTERGIlinsakfsgmdseEA-KWEITKFVGgER--KVqYR-- 521
Cdd:COG0525 342 ghsdRSGTVI----EP------YLSDQWFvkMKPL---AKPAI-------------EAvEDGEIKFVP-ERweKT-YFhw 393
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 ---LRDWLISRQRYWGPPIPMIFCEKcNWQPVPEQDLPVklpylkdwrpkgtgvsplaseskfykvkCPKCNGEA-RRET 597
Cdd:COG0525 394 menIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTEPEA----------------------------CAKAGSVNlTQDE 444
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 598 DVSDTfldsaWyffryldvknkkeiFSKALarkWlPvdmyiggaehavlhllyvrfitkvFADLG--------------- 662
Cdd:COG0525 445 DVLDT-----W--------------FSSAL---W-P------------------------FSTLGwpektedlkyfypts 477
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 663 -LV-GF-------------------REPskkFRA---HGLlIKD--GAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLG 716
Cdd:COG0525 478 vLVtGFdiiffwvarmimmglhftgEVP---FKDvyiHGL-VRDeqGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALA 553
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 717 PfdQGGDFR------DSG------ILGITRF-LARVQKFEKKLASTSKEGLAEN----SEriVHQSIKKITEDIESLRYN 779
Cdd:COG0525 554 S--PGRDIKfdeervEGYrnfankLWNASRFvLMNLEGFDPGLDPDPEELSLADrwilSR--LNKTIAEVTEALEKYRFD 629
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 780 TAVSQL--------------MI---LSNK-LEELPKVPWAAWEVF---LKLLAPFAPYISEELYQKFGKNKSfrkQNSVH 838
Cdd:COG0525 630 EAAQALydfvwnefcdwyleLAkprLYGGdEAAKRETRATLVYVLeqiLRLLHPFMPFITEEIWQKLPPRKE---GESIM 706
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....
gi 1083487655 839 LQSWPKYNAKKIKEDV---FLLVVQVNGKVRaTIQAPVGISEKDAERIALANEN 889
Cdd:COG0525 707 LAPWPEADEELIDEEAeaeFEWLKEVISAIR-NIRAEMNIPPSKKLPLLLKGAD 759
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
36-221 |
3.18e-28 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 117.73 E-value: 3.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 36 MMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENyalKVKRHPAKQAKI------------- 101
Cdd:cd00817 5 IDTPPPNVTGsLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQV---VVEKKLGIEGKTrhdlgreeflekc 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 102 ------SEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVvsgeCE 175
Cdd:cd00817 82 wewkeeSGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CS 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1083487655 176 RCESKVIKKELEQWFFRITNYAERLLKDLEK--IDWS-EKVKIAQRNWI 221
Cdd:cd00817 158 RSGDVIEPLLKPQWFVKVKDLAKKALEAVKEgdIKFVpERMEKRYENWL 206
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
726-825 |
4.85e-28 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 109.23 E-value: 4.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 726 DSGILGITRFLARVQKF-----EKKLASTSKEGLAENSE---RIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEELPK 797
Cdd:cd07958 3 DSGVEGAYRFLNRVWRLvtelaEALAAPAAAAELSEEDKelrRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKYKK 82
|
90 100 110
....*....|....*....|....*....|....*
gi 1083487655 798 -------VPWAAWEVFLKLLAPFAPYISEELYQKF 825
Cdd:cd07958 83 kdaqhaaVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
522-725 |
4.43e-23 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 102.32 E-value: 4.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 LRDWLISRQRYWGPPIPMIFCEKCN-WQPVPEQDLPVKLPylkdwrpkgtgvsplaseskFYKVKCPKCNGEARRETDVS 600
Cdd:cd00817 209 IRDWCISRQLWWGHRIPAWYCKDGGhWVVAREEDEAIDKA--------------------APEACVPCGGEELKQDEDVL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 601 DTFLDSAWYFFRYLDVKNKKEIFskalaRKWLPVDMYIGGaeHAVLH--LLYVRFITKVFADlglvgfREPSKKFRAHGL 678
Cdd:cd00817 269 DTWFSSSLWPFSTLGWPEETKDL-----KKFYPTSLLVTG--HDIIFfwVARMIMRGLKLTG------KLPFKEVYLHGL 335
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1083487655 679 LI-KDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPfdQGGDFR 725
Cdd:cd00817 336 VRdEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAAT--QGRDIN 381
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
4-894 |
3.13e-22 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 103.10 E-value: 3.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 4 FSRIEKKWNaLWRKTGVFEPELGRAKKPFYNLMmfPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGI 82
Cdd:PLN02943 63 FTSEERIYN-WWESQGYFKPNFDRGGDPFVIPM--PPPNVTGsLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 83 HSEnyaLKVKRHPA----KQAKISEKNFYR---------------QLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFK 143
Cdd:PLN02943 140 ATQ---LVVEKMLAsegiKRTDLGRDEFTKrvwewkekyggtitnQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHE 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 144 KGLAYRKKQAVNWCPDCKTVLADEQVVSGEcerceskvikkelEQWFFRITNYaerllkdlekidwsekvkiaqrnwigR 223
Cdd:PLN02943 217 KGLIYQGSYMVNWSPNLQTAVSDLEVEYSE-------------EPGTLYYIKY--------------------------R 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 224 SEGVEIEFkiqnsnlkIKVFTTRPDTLFGATYMVLSPEHEligklesrikNYQevkKYIqkartpaedkektgvelkGIK 303
Cdd:PLN02943 258 VAGGSEDF--------LTIATTRPETLFGDVAIAVNPEDD----------RYS---KYI------------------GKM 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 304 AVNPAN-KEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRaDIPIRSVlMGFDNIHSEELVSLGI 382
Cdd:PLN02943 299 AIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNK-DGTLNEV-AGLYWFEAREKLWSDL 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 383 KEVWPADKNHKY-IEIPENSL--PAFEKLIREKmtpgfWneYITHQRVififKDKNGL-VERLELTPGTDnkinRLSAIY 458
Cdd:PLN02943 377 EETGLAVKKEPHtLRVPRSQRggEVIEPLVSKQ-----W--FVTMEPL----AEKALKaVENGELTIIPE----RFEKIY 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 459 NnepepkgsvwNWLPDVpfykelfihtergilinsakfsgmdseeakweitkfvggerkvqyrlRDWLISRQRYWGPPIP 538
Cdd:PLN02943 442 N----------HWLSNI-----------------------------------------------KDWCISRQLWWGHRIP 464
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 539 MIFCEKCNWqpvpEQDLPVKlpylkdwrpKGTGVSPLASESKFYKvkcpkcNGEARRETDVSDTFLDSAWYFFRYLDVKN 618
Cdd:PLN02943 465 VWYIVGKDC----EEDYIVA---------RSAEEALEKAREKYGK------DVEIYQDPDVLDTWFSSALWPFSTLGWPD 525
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 619 kkeiFSKALARKWLPVDMYIGGaeHAVLHLLYVRFITKVFADLGLVgfrePSKKFRAHGlLIKD--GAKMSKSRGNVVSP 696
Cdd:PLN02943 526 ----VSAEDFKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHG-LIRDsqGRKMSKTLGNVIDP 594
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 697 DTYIKKFGADALRMYLMfLGPFDQGGDF---RDSGILGITRFLARVQKFE-KKLASTSKEGLAEN--------------- 757
Cdd:PLN02943 595 LDTIKEFGTDALRFTLA-LGTAGQDLNLsteRLTSNKAFTNKLWNAGKFVlQNLPSQSDTSAWEHilackfdkeesllsl 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 758 --SERIV----HQSIKKITEDIESLRYNTAVSQL-----------MILSNK-----------LEELPKVPWAAWEVFLKL 809
Cdd:PLN02943 674 plPECWVvsklHELIDSVTTSYDKYFFGDVGREIydffwsdfadwYIEASKtrlyhsgdnsaLSRAQAVLLYVFENILKL 753
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 810 LAPFAPYISEELYQKFgknkSFRKQnSVHLQSWPK----YNAKKIKEdvfllVVQVNGKVRATIQAPVGISEKDAERIA- 884
Cdd:PLN02943 754 LHPFMPFVTEELWQAL----PYRKE-ALIVSPWPQtslpKDLKSIKR-----FENLQSLTRAIRNARAEYSVEPAKRISa 823
|
970
....*....|..
gi 1083487655 885 --LANENVKKYL 894
Cdd:PLN02943 824 siVASAEVIEYI 835
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
5-351 |
1.64e-21 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 100.85 E-value: 1.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 5 SRIEKKWNALWRKTGVFEP----ELGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDG 79
Cdd:PTZ00419 31 KEVESGWYEWWEKSGFFKPaedaKSLNSGKKF--VIVLPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDH 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 80 FGIHS----ENYALK---VKRHPAKQAKISEK----------NFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMF 142
Cdd:PTZ00419 109 AGIATqvvvEKKLMKeenKTRHDLGREEFLKKvwewkdkhgnNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLY 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 143 KKGLAYRKKQAVNWCPDCKTVLADEQVvsgecerceskvikkeleqwffritnyaerllkDLEKIDWSEKVKIAqrnwiG 222
Cdd:PTZ00419 189 EDGLIYRDTRLVNWCCYLKTAISDIEV---------------------------------EFEEIEKPTKITIP-----G 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 223 RSEGVE------IEFKIQNSNL-KIKVFTTRPDTLFGATYMVLSPEHEligklesRIKNYQevkkyiqkartpaedkekt 295
Cdd:PTZ00419 231 YDKKVEvgvlwhFAYPLEDSGQeEIVVATTRIETMLGDVAVAVHPKDE-------RYKKLH------------------- 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1083487655 296 gvelkGIKAVNP-ANKEEIPIwVAD--YVLGGVGTGAIMAVPAHDERDFEFAKKFKLPI 351
Cdd:PTZ00419 285 -----GKELIHPfIPDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPF 337
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
665-826 |
1.13e-20 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 96.72 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF--RD---------SGILG-- 731
Cdd:COG0143 308 GLPLPKKVF-AHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFswEDfvarvnsdlANDLGnl 386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 732 ITRFLARVQK-FEKKLASTSKEGLAENS-ERIVHQSIKKITEDIESLRYNTAVSQLMILS---NK-LEElpKVPWA---- 801
Cdd:COG0143 387 ASRTLSMIHKyFDGKVPEPGELTEADEElLAEAEAALEEVAEAMEAFEFRKALEEIMALAraaNKyIDE--TAPWKlakd 464
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1083487655 802 ------------AWEVFLK---LLAPFAPYISEELYQKFG 826
Cdd:COG0143 465 edperlatvlytLLEALRIlaiLLKPFLPETAEKILEQLG 504
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
522-725 |
2.29e-18 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 87.09 E-value: 2.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 LRDWLISRQRYWGPPIPmifcekcnwqpvpeqdlpvklpylkdwrpkgtgvsplaseskfykvkcpkcngearreTDVSD 601
Cdd:cd00668 178 LLDWAISRQRYWGTPLP----------------------------------------------------------EDVFD 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 602 TFLDSAWYFFRYLDVKNKKEIFskalaRKWLPVDMYIGGAEHAVLHLLYvrFITKVFAdlglVGFREPSKKFRAHGL-LI 680
Cdd:cd00668 200 VWFDSGIGPLGSLGYPEEKEWF-----KDSYPADWHLIGKDILRGWANF--WITMLVA----LFGEIPPKNLLVHGFvLD 268
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1083487655 681 KDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQggDFR 725
Cdd:cd00668 269 EGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGD--DIR 311
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
38-228 |
2.45e-18 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 88.12 E-value: 2.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 38 FPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPA--------------KQAKISE 103
Cdd:pfam09334 7 LPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEelvdryheihredfKKFNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 104 KNFYRqlgmigngfawkekleTYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQvVSGEC--------- 174
Cdd:pfam09334 86 DDYGR----------------TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRY-VEGTCphcgsedar 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 175 -ERCE--------------------SKVIKKELEQWFFRITNYAERLLKDLEK--IDWSEKVKIAQRNWIgrSEGVE 228
Cdd:pfam09334 149 gDQCEncgrhleptelinpkcvicgTTPEVKETEHYFFDLSKFQDKLREWIEEnnPEWPENVKNMVLEWL--KEGLK 223
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
39-214 |
1.47e-17 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 87.09 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 39 PYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVF---------EPIGL--DGFGIHSENYALKV-KRHPA--KQAKISEK 104
Cdd:COG0143 10 PYANGP-PHIGHLYTYIPADILARYQRLRGHDVLfvtgtdehgTKIELaaEKEGITPQELVDRIhAEFKElfEKLGISFD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 105 NFYRqlgmigngfawkekleTYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLAD------------EQVVSG 172
Cdd:COG0143 89 NFIR----------------TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDryvegtcpkcgaEDAYGD 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 173 ECERCE-----------------SKVIKKELEQWFFRITNYAERLLKDLEKI-DWSEKVK 214
Cdd:COG0143 153 QCENCGatleptelinprsaisgAPPELREEEHYFFRLSKYQDRLLEWIEENpDIQPEVR 212
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
39-206 |
2.27e-17 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 86.47 E-value: 2.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 39 PYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGihsenyaLKVKRHpAKQAKISEKNFYRQlgmigNGFA 118
Cdd:PRK11893 10 YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHG-------QKIQRK-AEEAGISPQELADR-----NSAA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 119 WKEKLE-----------TYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVSGE--CERCESKVIKKE 185
Cdd:PRK11893 76 FKRLWEalnisyddfirTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGyrCPPTGAPVEWVE 155
|
170 180
....*....|....*....|.
gi 1083487655 186 LEQWFFRITNYAERLLKDLEK 206
Cdd:PRK11893 156 EESYFFRLSKYQDKLLELYEA 176
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
521-713 |
2.61e-17 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 84.21 E-value: 2.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 521 RLRDWLISRQRYWGPPIPMIFCEKCNwqpvpeqdlpvklpylkdwrpkgtgvsplaseskfyKVKCpkcngeaRRETDVS 600
Cdd:cd00818 188 NRRDWCISRQRYWGTPIPVWYCEDCG------------------------------------EVLV-------RRVPDVL 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 601 DTFLDS--AWYFfrYLDVKNKKEIFSkalaRKWlPVDMYIGGAEHA-----VLHLLYVrfitkvfadlGLVGfREPSKKF 673
Cdd:cd00818 225 DVWFDSgsMPYA--QLHYPFENEDFE----ELF-PADFILEGSDQTrgwfySLLLLST----------ALFG-KAPYKNV 286
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1083487655 674 RAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLM 713
Cdd:cd00818 287 IVHGFvLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVA 327
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
763-878 |
4.39e-17 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 78.60 E-value: 4.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 763 HQSIKKITEDIESLRYNTAVSQLM-----ILSNKLEELPK--------------VPWAAWEVFLKLLAPFAPYISEELYQ 823
Cdd:pfam08264 9 NKLIKEVTEAYENYRFNTAAQALYeffwnDLSDWYLELIKdrlygeepdsraqtTLYEVLETLLRLLAPFMPFITEELWQ 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 824 KfgknksfrkqNSVHLQSWPKYNAKKIKE-----DVFLLVVQVNGKVRATIQAPVGISEK 878
Cdd:pfam08264 89 K----------ESIHLAPWPEDAELEEAEleeafELRQEIVQAIRKLRSELKIKKSLPLE 138
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
5-708 |
5.54e-17 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 86.11 E-value: 5.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 5 SRIEKKWNALWRKTGVFEPELGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:PLN02381 103 SAVEKSWYAWWEKSGYFGADAKSSKPPF--VIVLPPPNVTGaLHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 84 SENYALK-------VKRHPAKQAK-ISE----KNFY-----RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGL 146
Cdd:PLN02381 181 TQVVVEKklmrerhLTRHDIGREEfVSEvwkwKDEYggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 147 AYRKKQAVNWcpDC--KTVLADEQVvsgecERCESKvikkelEQWFFRITNYAERLlkdlekidwsekvkiaqrnwigrS 224
Cdd:PLN02381 261 IYRDIRLVNW--DCtlRTAISDVEV-----DYIDIK------ERTLLKVPGYDKPV-----------------------E 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 225 EGVEIEFK--IQNSNLKIKVFTTRPDTLFGATYMVLSPEHEligklesRIKNyqevkkyiqkartpaedkektgveLKGI 302
Cdd:PLN02381 305 FGVLTSFAypLEGGLGEIVVATTRIETMLGDTAIAIHPDDE-------RYKH------------------------LHGK 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 303 KAVNPANKEEIPIwVADYVL--GGVGTGAIMAVPAHDERDFEFAKKFKLPikpvirradipirsvlmgFDNIHSEELvsl 380
Cdd:PLN02381 354 FAVHPFNGRKLPI-ICDAILvdPNFGTGAVKITPAHDPNDFEVGKRHNLE------------------FINIFTDDG--- 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 381 gikevwpadknhkyiEIPENSLPAFEKLIRekmtpgfwneyithqrvifiFKDKNGLVERLE---LTPGTDNKINRL--S 455
Cdd:PLN02381 412 ---------------KINSNGGSEFAGMPR--------------------FAAREAVIEALQkkgLYRGAKNNEMRLglC 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 456 AIYNNEPEPKgsvwnwlpdvpFYKELFIHTErgILINSAKFSGMDSEEAKWEI--TKFVGGERKVQYRLRDWLISRQRYW 533
Cdd:PLN02381 457 SRTNDVVEPM-----------IKPQWFVNCS--SMAKQALDAAIDGENKKLEFipKQYLAEWKRWLENIRDWCISRQLWW 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 534 GPPIPMifcekcnWQPVPEQDLPVKLPYLKD-WRPKGTGVSPLASESKfykvKCPKCNGEARRETDVSDTFLDSAWYFFR 612
Cdd:PLN02381 524 GHRIPA-------WYVTLEDDQLKELGSYNDhWVVARNESDALLEASQ----KFPGKKFELSQDPDVLDTWFSSGLFPLS 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 613 YLDVKNKKEIFskalaRKWLPVDMYIGGaeHAVLHLLYVRFITkvfadLGL-VGFREPSKKFRAHGlLIKD--GAKMSKS 689
Cdd:PLN02381 593 VLGWPDDTDDL-----KAFYPTSVLETG--HDILFFWVARMVM-----MGMqLGGDVPFRKVYLHP-MIRDahGRKMSKS 659
|
730
....*....|....*....
gi 1083487655 690 RGNVVSPDTYIKKFGADAL 708
Cdd:PLN02381 660 LGNVIDPLEVINGISLEGL 678
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
31-221 |
8.90e-17 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 82.08 E-value: 8.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 31 PFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYA-------------LKVKRHPAK 97
Cdd:cd00668 1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 98 QAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVnwcpdcktvladeqvvsgecerc 177
Cdd:cd00668 80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV----------------------- 136
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1083487655 178 eskvikKELEQWFFRITNYAERLLKDLEKIDW-SEKVKIAQRNWI 221
Cdd:cd00668 137 ------RITEQWFFDMPKFKEKLLKALRRGKIvPEHVKNRMEAWL 175
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
39-221 |
1.91e-16 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 81.42 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 39 PYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQA-KISE--KNFYRQLGMIGN 115
Cdd:cd00814 9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCdKYHEifKDLFKWLNISFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 116 GFAwkeklETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLAdeqvvsgecerceskVIKKElEQWFFRITN 195
Cdd:cd00814 88 YFI-----RTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP---------------EWREE-EHYFFRLSK 146
|
170 180
....*....|....*....|....*....
gi 1083487655 196 YAERLLKDLEK---IDWSEKVKIAQRNWI 221
Cdd:cd00814 147 FQDRLLEWLEKnpdFIWPENARNEVLSWL 175
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
8-848 |
8.63e-16 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 82.13 E-value: 8.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 8 EKKWNALWRKTGVFEPELGRAKKPFYNLMMFPyPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSEn 86
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGESFTLHDGP-PYANGdLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 87 yaLKV-------KRHPAKQAKISEK--NF-----------YRQLGMIGNgfaWKEKLETYDPEYYKWTQWIFVQMFKKGL 146
Cdd:PLN02843 87 --LKVlqsldqeARKELTPIKLRAKaaKFakktvdtqresFKRYGVWGD---WENPYLTLDPEYEAAQIEVFGQMFLNGY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 147 AYRKKQAVNWCPDCKTVLADeqvvsGECERCESKVIKKELEQwfFRITNYAERLlkdlekidwsekvkiaqrnwigrseG 226
Cdd:PLN02843 162 IYRGRKPVHWSPSSRTALAE-----AELEYPEGHVSKSIYVA--FPVVSPSETS-------------------------P 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 227 VEIEFKIQNSNLKIkvFTTRPDTLFG---------ATYMVL---SPEHELIGKLESRIKNYQEVKKYIQKAR-TPAED-- 291
Cdd:PLN02843 210 EELEEFLPGLSLAI--WTTTPWTMPAnaavavndkLQYSVVevqSFSEDESTSGGNKKKRPGNVLKEQQKLFlIVATDlv 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 292 ---KEKTGVELKGIKAV-----------NPANKEEIPIWVA-DYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPI-KPV- 354
Cdd:PLN02843 288 palEAKWGVKLVVLKTFpgsdlegcryiHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLlSPVd 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 355 ------IRRADIPIRSVLmGFDNI----HSEELVSLGIKEVWpadkNHKYieipenslpafeklirekmtPGFWNeyiTH 424
Cdd:PLN02843 368 dagkftEEAGQFSGLSVL-GEGNAavveALDEAGSLLMEEAY----GHKY--------------------PYDWR---TK 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 425 QRVIF-----IFKDKNGLVErleltpgtdnkiNRLSAIYNNEpepkgsvwnWLPdvpfykelfihtergilinsakfsgm 499
Cdd:PLN02843 420 KPTIFrateqWFASVEGFRQ------------AALDAIDKVK---------WIP-------------------------- 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 500 dsEEAKWEITKFVGGeRKvqyrlrDWLISRQRYWGPPIPmIFCEKCNWQPVPEQDlpvKLPYLKD-WRPKGT------GV 572
Cdd:PLN02843 453 --AQGENRIRAMVSG-RS------DWCISRQRTWGVPIP-VFYHVETKEPLMNEE---TIAHVKSiVAQKGSdawwymDV 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 573 SPLASESkfYKVKCPKcngeARRETDVSDTFLDSAwyfFRYLDVKNKKEIFSkalarkwLPVDMYIGGAEHavlH----- 647
Cdd:PLN02843 520 EDLLPEK--YRDKASD----YEKGTDTMDVWFDSG---SSWAGVLGSREGLS-------YPADLYLEGSDQ---Hrgwfq 580
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 648 --LLyvrfiTKVfADLGlvgfREPSKKFRAHG-LLIKDGAKMSKSRGNVVSPDTYI-----KK----FGADALRMYlmfL 715
Cdd:PLN02843 581 ssLL-----TSV-ATKG----KAPYKSVLTHGfVLDEKGFKMSKSLGNVVDPRLVIeggknQKqepaYGADVLRLW---V 647
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 716 GPFDQGGDFR-DSGIL-----------GITRFL-ARVQKFEKKLASTSKE--GLAENSERIVHQSIKKITEDIESLRYNT 780
Cdd:PLN02843 648 ASVDYTGDVLiGPQILkqmsdiyrklrGTLRYLlGNLHDWKPDNAVPYEDlpSIDKYALFQLENVVNEIEESYDNYQFFK 727
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 781 AVSQL-----MILSNKLEELPK------------------VPWAAWEVFLKLLAPFAPYISEELYQKFGKNKSFRKQNSV 837
Cdd:PLN02843 728 IFQILqrftiVDLSNFYLDVAKdrlyvggttsftrrscqtVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESV 807
|
970
....*....|.
gi 1083487655 838 HLQSWPKYNAK 848
Cdd:PLN02843 808 FEAGWPTPNEE 818
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
661-826 |
1.07e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 81.39 E-value: 1.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 661 LGLvgfrEPSKKFRAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGI----------- 729
Cdd:PRK12267 279 LGL----PLPKKVFAHGWWLMKDGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSPEALverinsdland 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 730 LG--ITRFLARVQK-FEKKL-ASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMIL---SNKL---------- 792
Cdd:PRK12267 355 LGnlLNRTVAMINKyFDGEIpAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLisrANKYidetapwvla 434
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1083487655 793 ------EELPKVPWAAWEVFLK---LLAPFAPYISEELYQKFG 826
Cdd:PRK12267 435 kdegkkERLATVMYHLAESLRKvavLLSPFMPETSKKIFEQLG 477
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
671-826 |
2.09e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 79.93 E-value: 2.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 671 KKFRAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGI-----------LG--ITRFLA 737
Cdd:PRK11893 285 KRVFAHGFLTLDGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFinrinadlandLGnlAQRTLS 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 738 RVQK-FEKKLASTSKEGLAENSERI-VHQSIKKITEDIESLRYNTAVSQLMILSNKL-----EELPKVPWAAWEVFLK-- 808
Cdd:PRK11893 365 MIAKnFDGKVPEPGALTEADEALLEaAAALLERVRAAMDNLAFDKALEAILALVRAAnkyidEQAPWSLAKTDPERLAtv 444
|
170 180 190
....*....|....*....|....*....|.
gi 1083487655 809 -------------LLAPFAPYISEELYQKFG 826
Cdd:PRK11893 445 lytllevlrgiavLLQPVMPELAAKILDQLG 475
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
665-724 |
5.50e-14 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 74.11 E-value: 5.50e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF 724
Cdd:cd00814 261 GLPLPTRIV-AHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
41-221 |
1.17e-13 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 73.42 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 41 PSAEGL-HVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFG---------------------IHSENYALKVKRHPAKQ 98
Cdd:cd00818 10 PYANGLpHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGlpielkvekelgisgkkdiekMGIAEFNAKCREFALRY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 99 AKISEKNFYRqLGMIGNgfaWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWcPdcktvladeqvvsgecerce 178
Cdd:cd00818 90 VDEQEEQFQR-LGVWVD---WENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P-------------------- 144
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1083487655 179 skVIKKELEQWFFRITNYAERLLKDLEKIDW-SEKVKIAQRNWI 221
Cdd:cd00818 145 --LIYRATPQWFIRVTKIKDRLLEANDKVNWiPEWVKNRFGNWL 186
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
665-739 |
1.66e-13 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 73.48 E-value: 1.66e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGilgitrFLARV 739
Cdd:pfam09334 305 GYRLPTTVF-AHGYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWED------FVERV 372
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
763-854 |
3.85e-11 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 62.95 E-value: 3.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 763 HQSIKKITEDIESLRYNTAVSQLM----ILSN----------KLEELPKVPWAAWEV-------FLKLLAPFAPYISEEL 821
Cdd:cd07961 57 NSLIKEVTEEMEAYDLYTAVRALLefidELTNwyirrnrkrfWGEEGDDDKLAAYATlyevlltLSRLMAPFTPFITEEI 136
|
90 100 110
....*....|....*....|....*....|...
gi 1083487655 822 YQKFGKNKSFRKQnSVHLQSWPKYNAKKIKEDV 854
Cdd:cd07961 137 YQNLRRELGDAPE-SVHLLDWPEVDESLIDEEL 168
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
29-202 |
5.32e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 66.36 E-value: 5.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 29 KKPFYnlMMFP--YPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGihsenyaLKVKRhPAKQAKISEKNF 106
Cdd:PRK12267 3 KKTFY--ITTPiyYPNGK-PHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG-------QKIQQ-AAEKAGKTPQEY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 107 -------YRQLgmigngfaWKeKLE--------TYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVS 171
Cdd:PRK12267 72 vdeisagFKEL--------WK-KLDisydkfirTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVD 142
|
170 180 190
....*....|....*....|....*....|..
gi 1083487655 172 GE-CERCESKVIKKELEQWFFRITNYAERLLK 202
Cdd:PRK12267 143 GGkCPDCGREVELVKEESYFFRMSKYQDRLLE 174
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
523-854 |
9.45e-11 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 65.90 E-value: 9.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 523 RDWLISRQRYWGPPIPMifcekcnWQPVPEQDLPV-----KLPYLKdwrpkGTGVSPLASEsKFYKVKCPKCNG----EA 593
Cdd:PLN02882 465 RDWAVSRSRFWGTPLPI-------WISDDGEEVVVigsiaELEKLS-----GVKVTDLHRH-FIDHITIPSSRGpefgVL 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 594 RRETDVSDTFLDSAW--YFFRYLDVKNKkEIFSKALarkwlPVDMYIGGaehavlhLLYVR--FITKVFADLGLvgFREP 669
Cdd:PLN02882 532 RRVDDVFDCWFESGSmpYAYIHYPFENK-ELFEKNF-----PADFVAEG-------LDQTRgwFYTLMVLSTAL--FDKP 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 670 S-KKFRAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFlGPFDQGGD--FRDSGILGIT-----------R 734
Cdd:PLN02882 597 AfKNLICNGLvLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN-SPVVRAEPlrFKEEGVFGVVkdvflpwynayR 675
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 735 FLarVQKFEK-------KLASTSKEGLAENS---ERIVHQS----IKKITEDIESLRYNTAVSQLMILSNKL-------- 792
Cdd:PLN02882 676 FL--VQNAKRleveggaPFVPLDLAKLQNSAnvlDRWINSAtqslVKFVREEMGAYRLYTVVPYLVKFIDNLtniyvrfn 753
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1083487655 793 ---------EELPKVPWAA-WEVFL---KLLAPFAPYISEELYQKFGKNKSfRKQNSVHLQSWPKYNAKKIKEDV 854
Cdd:PLN02882 754 rkrlkgrtgEEDCRTALSTlYNVLLtscKVMAPFTPFFTEVLYQNLRKVLP-GSEESIHYCSFPQVDEGELDERI 827
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
665-826 |
4.86e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 63.25 E-value: 4.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGP---------FDqggDFRDS------GI 729
Cdd:PRK00133 310 GYRLPTNVF-AHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPetiddldfnWE---DFQQRvnselvGK 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 730 LG--ITR---FLARvqKFEKKLASTSKEglAENSERIVhQSIKKITEDIESLRYNTAVSQLMILS---NK-LEElpKVPW 800
Cdd:PRK00133 386 VVnfASRtagFINK--RFDGKLPDALAD--PELLEEFE-AAAEKIAEAYEAREFRKALREIMALAdfaNKyVDD--NEPW 458
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1083487655 801 AAWE------------------VFLKLLAPFAPYISEELYQKFG 826
Cdd:PRK00133 459 KLAKqdgerlqavcsvglnlfrALAIYLKPVLPELAERAEAFLN 502
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
39-180 |
5.97e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 62.86 E-value: 5.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 39 PYpsAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVF---------EPIGL--DGFGIHSENYALKV-KRHPA--KQAKISE 103
Cdd:PRK00133 11 PY--ANGpIHLGHLVEYIQADIWVRYQRMRGHEVLfvcaddahgTPIMLkaEKEGITPEELIARYhAEHKRdfAGFGISF 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083487655 104 KNFYRqlgmigngfawkekleTYDPEYYKWTQWIFVQMFKKGLAYRK--KQAvnWCPDCKTVLADEQVVsGECERCESK 180
Cdd:PRK00133 89 DNYGS----------------THSEENRELAQEIYLKLKENGYIYEKtiEQL--YDPEKGMFLPDRFVK-GTCPKCGAE 148
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
523-864 |
4.49e-08 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 57.28 E-value: 4.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 523 RDWLISRQRYWGPPIPMIFCEKCNWQPVPEQdlpvkLPYLKdwrpKGTGVSPLASESKFY----KVKCPKCNG--EARRE 596
Cdd:PTZ00427 569 KDWCISRNRYWGTPIPIWADEKMETVICVES-----IKHLE----ELSGVKNINDLHRHFidhiEIKNPKGKTypKLKRI 639
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 597 TDVSDTFLDSAW--YFFRYLDVKNKKEIFSKALarkwlPVDMYIGGAEHAVLHLLYVRFITKVFADlglvgfREPSKKFR 674
Cdd:PTZ00427 640 PEVFDCWFESGSmpYAKVHYPFSTEKEDFHKIF-----PADFIAEGLDQTRGWFYTLLVISTLLFD------KAPFKNLI 708
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 675 AHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLM-FLGPFDQGGDFRDSGILGITR------------FLARVQ 740
Cdd:PTZ00427 709 CNGLvLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLInSVAVRAENLKFQEKGVNEVVKsfilpfyhsfrfFSQEVT 788
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 741 KFE---KKLASTSKEGLAENSE--------------RIVHQSIK---------KITEDIESL-----RYNTAVSQLMILS 789
Cdd:PTZ00427 789 RYEclnKKQFLFNTDYIYKNDNimdqwifssvqsltKSVHTEMKayklynvlpKLLQFIENLtnwyiRLNRDRMRGSLGE 868
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083487655 790 NKLEELPKVPWAAWEVFLKLLAPFAPYISEELYQKFGKNKSFRKQNSVHLQ---SWPKYNAKKIKEDV-FLLVVQVNGK 864
Cdd:PTZ00427 869 ENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKSTNEHNENNETgntKEGDLNRGVIHKSVhFIMLPQVDEK 947
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
603-826 |
4.52e-08 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 57.03 E-value: 4.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 603 FLDSAWYFFRYLDVKNKKEIFSKALARKWlPVDMYIGGAEHAVLHLLYVRfitkvfADLGLVGFREPSKKFrAHGLLIKD 682
Cdd:PLN02224 292 WFDALLGYISALTEDNKQQNLETAVSFGW-PASLHLIGKDILRFHAVYWP------AMLMSAGLELPKMVF-GHGFLTKD 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 683 GAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGIT---------RFLARVQKFEKKL------- 746
Cdd:PLN02224 364 GMKMGKSLGNTLEPFELVQKFGPDAVRYFFLREVEFGNDGDYSEDRFIKIVnahlantigNLLNRTLGLLKKNcestlve 443
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 747 -ASTSKEG--LAENSERIVhqsiKKITEDIESLRYNTAVSQLMILSNKLEEL--PKVPW------------AAWEVFLKL 809
Cdd:PLN02224 444 dSTVAAEGvpLKDTVEKLV----EKAQTNYENLSLSSACEAVLEIGNAGNTYmdQRAPWflfkqggvsaeeAAKDLVIIL 519
|
250 260
....*....|....*....|....*.
gi 1083487655 810 ---------LAPFAPYISEELYQKFG 826
Cdd:PLN02224 520 evmrviavaLSPIAPCLSLRIYSQLG 545
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
47-204 |
4.00e-06 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 50.48 E-value: 4.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 47 HVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQAKI---SEKNFYRQLGMigngfAWKEKL 123
Cdd:PLN02224 85 HMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIisqSYRTLWKDLDI-----AYDKFI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 124 ETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVSGECerC---ESKVIKKELEQWFFRITNYaERL 200
Cdd:PLN02224 160 RTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CpvhQMPCVARKEDNYFFALSKY-QKP 236
|
....
gi 1083487655 201 LKDL 204
Cdd:PLN02224 237 LEDI 240
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
763-825 |
7.15e-06 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 46.40 E-value: 7.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 763 HQSIKKITEDIESLRYNTAVSQL--------------MI---LSNKLEELPKVPWA----AWEVFLKLLAPFAPYISEEL 821
Cdd:cd07962 52 NKTVEEVTEALENYRFSEAATALyeffwndfcdwyleLVkprLYGEDEEEKKAARAtlyyVLETILRLLHPFMPFITEEL 131
|
....
gi 1083487655 822 YQKF 825
Cdd:cd07962 132 WQRL 135
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
724-825 |
1.76e-05 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 44.89 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 724 FRDSGILGITRFLARVQKFEKKLASTSKEGLAEN-------SEriVHQSIKKITEDIESLRYNTAV-SQLMILSNKLEE- 794
Cdd:cd07959 1 FREEEANSAILRLERFYELAEELIETEGELEELTfidrwllSR--LNRLIKETTEAYENMQFREALkEGLYELQNDLDWy 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 1083487655 795 ---LPKVP-----WAAWEVFLKLLAPFAPYISEELYQKF 825
Cdd:cd07959 79 rerGGAGMnkdllRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
676-713 |
3.39e-04 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 44.32 E-value: 3.39e-04
10 20 30
....*....|....*....|....*....|....*...
gi 1083487655 676 HGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLM 713
Cdd:COG0215 256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLL 293
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
804-854 |
1.29e-03 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 40.59 E-value: 1.29e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1083487655 804 EVFLKLLAPFAPYISEELYQKFGKNKsfrKQNSVHLQSWPKYNAKKIKEDV 854
Cdd:cd07960 118 DALLKLLAPILPFTAEEVWEHLPGEK---KEESVFLEDWPELPEEWKDEEL 165
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
735-814 |
1.85e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 39.03 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 735 FLARVQKFEKKLASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEELPKVPW-------------- 800
Cdd:cd07375 21 FRKALGGTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNELNWYLDELKpalqteelreavla 100
|
90
....*....|....*..
gi 1083487655 801 ---AAWEVFLKLLAPFA 814
Cdd:cd07375 101 vlrAALVVLTKLLAPFT 117
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
605-847 |
4.34e-03 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 40.82 E-value: 4.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 605 DSAW-YFFRYLDVKNKKEIFSKALARK------WLPVDMYIGGAEHAVLHLLYVRFI-TKVFADlglvgfREPSKKFRAH 676
Cdd:PLN02959 636 DEVWdFVFCGGPLPKSSDIPAELLEKMkqefeyWYPFDLRVSGKDLIQNHLTFAIYNhTAIWAE------EHWPRGFRCN 709
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 677 GLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF----RDSGILGITRFLA---RVQKFEKKLAST 749
Cdd:PLN02959 710 GHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFvfetANAAILRLTKEIAwmeEVLAAESSLRTG 789
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 750 SKEGLA----ENSERIVHQSIKKITEDI---ESLRynTAVSQLMI------LSNKLEELPK-VPWAAWEVFLKLLAPFAP 815
Cdd:PLN02959 790 PPSTYAdrvfENEINIAIAETEKNYEAMmfrEALK--SGFYDLQAardeyrLSCGSGGMNRdLVWRFMDVQTRLITPICP 867
|
250 260 270
....*....|....*....|....*....|..
gi 1083487655 816 YISEELYQKFgknksFRKQNSVHLQSWPKYNA 847
Cdd:PLN02959 868 HYAEHVWREI-----LKKEGFAVTAGWPVAGE 894
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
47-177 |
5.42e-03 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 40.53 E-value: 5.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 47 HVGNMYAFVGS-DIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPA----KQAKIsEKNFYRQLGMIGNGFAwke 121
Cdd:PLN02610 33 HLGNIIGCVLSaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKeicdKYHAI-HKEVYDWFDISFDKFG--- 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1083487655 122 klETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADeQVVSGECERC 177
Cdd:PLN02610 109 --RTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLAD-RLVEGTCPTE 161
|
|
|