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Conserved domains on  [gi|1083487655|gb|OGF90108|]
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leucine--tRNA ligase [Candidatus Giovannonibacteria bacterium RIFCSPLOWO2_01_FULL_48_47]

Protein Classification

leucine--tRNA ligase( domain architecture ID 11423059)

leucine--tRNA ligase attaches leucine to the ribose 3' OH group of tRNA(Leu)

CATH:  3.90.740.10
EC:  6.1.1.4
PubMed:  13792726
SCOP:  4002332

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
4-913 0e+00

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


:

Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 1152.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:COG0495     7 PKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  84 SENYALKVKRHPAK--QAKIseKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:COG0495    86 AENAAIKNGVHPAEwtYENI--ANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKI 240
Cdd:COG0495   164 TVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDEKI 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 241 KVFTTRPDTLFGATYMVLSPEHELIGKLESrIKNYQEVKKYIQKART------PAEDKEKTGVELkGIKAVNPANKEEIP 314
Cdd:COG0495   244 TVFTTRPDTLFGATFMVLAPEHPLVKELAT-PEQNAAVAAFIEEAKKkseierTSETKEKTGVFT-GLYAINPLTGEKIP 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 315 IWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIPirsvlmgfdnihseelvslgikevwpadknhky 394
Cdd:COG0495   322 IWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD--------------------------------- 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 395 ieipenslpafeklirekmTPGFWNEyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpd 474
Cdd:COG0495   369 -------------------DPDILEE------------------------------------------------------ 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 475 vPFykelfihTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPV 550
Cdd:COG0495   376 -AY-------TGDGVLINSGEFDGLDSEEAKEAIIEWLEekglGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPV 447
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 551 PEQDLPVKLPYLKDwrPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARK 630
Cdd:COG0495   448 PEDQLPVELPEDVD--FDPTGGSPLARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANY 525
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 631 WLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGL---LIKDG------AKMSKSRGNVVSPDTYIK 701
Cdd:COG0495   526 WLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVSFDEPFKRLLTQGMvleVGKDGvviggiEKMSKSKGNVVDPDEIIE 605
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 702 KFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKKLASTSKEGLAENSE------RIVHQSIKKITEDIES 775
Cdd:COG0495   606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALKLDVADLSEadkelrRALHKTIKKVTEDIER 685
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 776 LRYNTAVSQLMILSNKLEELPK-------VPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAK 848
Cdd:COG0495   686 LRFNTAIAALMELVNALYKAKDsgeadraVLREALETLVLLLAPFAPHIAEELWERLG------HEGSVADAPWPEADEA 759
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 849 KIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYlLPG--LRKTIFVPDKLINFVV 913
Cdd:COG0495   760 ALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKF-LEGktIRKVIVVPGKLVNIVV 825
 
Name Accession Description Interval E-value
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
4-913 0e+00

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 1152.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:COG0495     7 PKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  84 SENYALKVKRHPAK--QAKIseKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:COG0495    86 AENAAIKNGVHPAEwtYENI--ANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKI 240
Cdd:COG0495   164 TVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDEKI 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 241 KVFTTRPDTLFGATYMVLSPEHELIGKLESrIKNYQEVKKYIQKART------PAEDKEKTGVELkGIKAVNPANKEEIP 314
Cdd:COG0495   244 TVFTTRPDTLFGATFMVLAPEHPLVKELAT-PEQNAAVAAFIEEAKKkseierTSETKEKTGVFT-GLYAINPLTGEKIP 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 315 IWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIPirsvlmgfdnihseelvslgikevwpadknhky 394
Cdd:COG0495   322 IWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD--------------------------------- 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 395 ieipenslpafeklirekmTPGFWNEyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpd 474
Cdd:COG0495   369 -------------------DPDILEE------------------------------------------------------ 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 475 vPFykelfihTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPV 550
Cdd:COG0495   376 -AY-------TGDGVLINSGEFDGLDSEEAKEAIIEWLEekglGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPV 447
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 551 PEQDLPVKLPYLKDwrPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARK 630
Cdd:COG0495   448 PEDQLPVELPEDVD--FDPTGGSPLARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANY 525
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 631 WLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGL---LIKDG------AKMSKSRGNVVSPDTYIK 701
Cdd:COG0495   526 WLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVSFDEPFKRLLTQGMvleVGKDGvviggiEKMSKSKGNVVDPDEIIE 605
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 702 KFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKKLASTSKEGLAENSE------RIVHQSIKKITEDIES 775
Cdd:COG0495   606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALKLDVADLSEadkelrRALHKTIKKVTEDIER 685
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 776 LRYNTAVSQLMILSNKLEELPK-------VPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAK 848
Cdd:COG0495   686 LRFNTAIAALMELVNALYKAKDsgeadraVLREALETLVLLLAPFAPHIAEELWERLG------HEGSVADAPWPEADEA 759
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 849 KIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYlLPG--LRKTIFVPDKLINFVV 913
Cdd:COG0495   760 ALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKF-LEGktIRKVIVVPGKLVNIVV 825
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
4-913 0e+00

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 899.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:TIGR00396   3 HIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  84 SENYALKVKRHPAKQAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTV 163
Cdd:TIGR00396  82 AENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 164 LADEQVVS-GECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKIK 241
Cdd:TIGR00396 162 LANEQVDSdGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHDEKIT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 242 VFTTRPDTLFGATYMVLSPEHELIGKLesrIKNYQEVKKYIQKARTP------AEDKEKTGVELkGIKAVNPANKEEIPI 315
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLVEKA---AENNPKVAAFIKKILNKtvaertKATKEKKGVDT-GIKAIHPLTGEKIPI 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 316 WVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRradipirsvlmgfdnihseelvslgikevwPADKNHKYI 395
Cdd:TIGR00396 318 WVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVID------------------------------PAEKDLSLT 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 396 Eipenslpafeklirekmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpdv 475
Cdd:TIGR00396 368 A------------------------------------------------------------------------------- 368
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 476 pfykelfIHTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPVP 551
Cdd:TIGR00396 369 -------AYTEDGVLVNSGEFNGLNSSEARNAIIDMLEkegkGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVP 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 552 EQDLPVKLPYLKDWRPKGTgvSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARKW 631
Cdd:TIGR00396 442 EEDLPVILPEDVVYDGDGG--SPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYW 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 632 LPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKF--------------------------------RAHGLL 679
Cdd:TIGR00396 520 LPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLinqgmvlgfyyppngkvpadvlterdekgkdkAGGELV 599
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 IKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKK---------LASTS 750
Cdd:TIGR00396 600 YVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEitgeldaasLTVTA 679
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 751 KEGLAENSERIVHQSIKKITEDIESLR-YNTAVSQLMILSNKLEELPK--VPWAAWEVFLKLLAPFAPYISEELYQKFGK 827
Cdd:TIGR00396 680 LEEAQKELRRDVHKFLKKVTEDLEKREsFNTAISAMMELLNKLYKAKKeaLMLEYLKGFVTVLSPFAPHLAEELWEKLGS 759
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 828 NKSfrkqnSVHLQSWPKYNAKKIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYLL-PGLRKTIFVPD 906
Cdd:TIGR00396 760 EPF-----IIDNAKWPVVDETALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLEnKTIKKVIYVPG 834

                  ....*..
gi 1083487655 907 KLINFVV 913
Cdd:TIGR00396 835 KLVNFVI 841
PLN02563 PLN02563
aminoacyl-tRNA ligase
4-913 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 797.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFE-PELGRAKKP-FYNLMMFPYPSAEGLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFG 81
Cdd:PLN02563   82 FHEIEPKWQRYWEENRTFRtPDDVDTSKPkFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFG 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  82 IHSENYALKVKRHPAKQAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:PLN02563  162 LPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALG 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKIDWSEKVKIAQRNWIGRSEGVEIEFKI-----QNS 236
Cdd:PLN02563  242 TVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVldgegKER 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 237 NLKIKVFTTRPDTLFGATYMVLSPEHELIGKLESRIKNyQEVKKYIQKA-------RTPAEdKEKTGVeLKGIKAVNPAN 309
Cdd:PLN02563  322 DEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQK-EAVEEYVDAAsrksdleRTELQ-KEKTGV-FTGSYAINPAT 398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 310 KEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIpirsvlmgfdnihseelvslgikEVWPAD 389
Cdd:PLN02563  399 GEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADG-----------------------NEDDAE 455
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 390 Knhkyieipenslpafeklirekmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvw 469
Cdd:PLN02563  456 K------------------------------------------------------------------------------- 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 470 nwlpdvpfykelfIHTERGILINSA----KFSGMDSEEAKWEITKFV----GGERKVQYRLRDWLISRQRYWGPPIPMIF 541
Cdd:PLN02563  457 -------------AYTGEGVIVNSSssglDINGLSSKEAAKKVIEWLeetgNGKKKVNYKLRDWLFARQRYWGEPIPVVF 523
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 542 CEKCNWQ-PVPEQDLPVKLPYLKDWRPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKK 620
Cdd:PLN02563  524 LEDSGEPvPVPESDLPLTLPELDDFTPTGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSN 603
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 621 EIFSKALARKWLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGLL--------------------- 679
Cdd:PLN02563  604 ALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMIlgeveytafkdsdgeyvsadt 683
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 -----------------IKDGA-----------------KMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFR 725
Cdd:PLN02563  684 adrlgelqqekipeekvIKSGDsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWS 763
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 726 DSGILGITRFLARV----------QKFEKKLASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEEL 795
Cdd:PLN02563  764 TSGVEGVHRFLGRTwrlvvgaplpDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKW 843
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 796 PKVPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAKKIKEDVFLLVVQVNGKVRATIQAPVGI 875
Cdd:PLN02563  844 DKVPREAIEPFVLLLSPYAPHLAEELWFRLG------HSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGC 917
                         970       980       990
                  ....*....|....*....|....*....|....*....
gi 1083487655 876 SEKDAERIALANENVKKYLL-PGLRKTIFVPDKLINFVV 913
Cdd:PLN02563  918 SEDDAFALASQDEKLSKYLDgKEIKKRIYVPGKILNVIL 956
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
218-359 1.03e-72

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 237.06  E-value: 1.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 218 RNWIGRSEGVEIEFKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHELIGKLEsriKNYQEVKKYIQKARTP------AED 291
Cdd:pfam13603   1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLA---EKNPEVAAFIEECKNTseiertSET 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1083487655 292 KEKTGVeLKGIKAVNPANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAD 359
Cdd:pfam13603  78 KEKEGV-FTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPED 144
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
32-222 2.12e-52

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 185.91  E-value: 2.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  32 FYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQAKISEKNFYRQLG 111
Cdd:cd00812     2 FYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 112 MIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCpdcktvladeqvvsgecerceskvikKELEQWFF 191
Cdd:cd00812    81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1083487655 192 RI--TNYAERLLKDLEKID-WSEKVKIAQRNWIG 222
Cdd:cd00812   135 KYseTEWKEKLLKDLEKLDgWPEEVRAMQENWIG 168
 
Name Accession Description Interval E-value
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
4-913 0e+00

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 1152.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:COG0495     7 PKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDAFGLP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  84 SENYALKVKRHPAK--QAKIseKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:COG0495    86 AENAAIKNGVHPAEwtYENI--ANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKI 240
Cdd:COG0495   164 TVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDEKI 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 241 KVFTTRPDTLFGATYMVLSPEHELIGKLESrIKNYQEVKKYIQKART------PAEDKEKTGVELkGIKAVNPANKEEIP 314
Cdd:COG0495   244 TVFTTRPDTLFGATFMVLAPEHPLVKELAT-PEQNAAVAAFIEEAKKkseierTSETKEKTGVFT-GLYAINPLTGEKIP 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 315 IWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIPirsvlmgfdnihseelvslgikevwpadknhky 394
Cdd:COG0495   322 IWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDGD--------------------------------- 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 395 ieipenslpafeklirekmTPGFWNEyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpd 474
Cdd:COG0495   369 -------------------DPDILEE------------------------------------------------------ 375
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 475 vPFykelfihTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPV 550
Cdd:COG0495   376 -AY-------TGDGVLINSGEFDGLDSEEAKEAIIEWLEekglGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPV 447
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 551 PEQDLPVKLPYLKDwrPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARK 630
Cdd:COG0495   448 PEDQLPVELPEDVD--FDPTGGSPLARAPEWVNVTCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANY 525
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 631 WLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGL---LIKDG------AKMSKSRGNVVSPDTYIK 701
Cdd:COG0495   526 WLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLVSFDEPFKRLLTQGMvleVGKDGvviggiEKMSKSKGNVVDPDEIIE 605
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 702 KFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKKLASTSKEGLAENSE------RIVHQSIKKITEDIES 775
Cdd:COG0495   606 KYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRLVVDEAEALKLDVADLSEadkelrRALHKTIKKVTEDIER 685
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 776 LRYNTAVSQLMILSNKLEELPK-------VPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAK 848
Cdd:COG0495   686 LRFNTAIAALMELVNALYKAKDsgeadraVLREALETLVLLLAPFAPHIAEELWERLG------HEGSVADAPWPEADEA 759
                         890       900       910       920       930       940
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 849 KIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYlLPG--LRKTIFVPDKLINFVV 913
Cdd:COG0495   760 ALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADEKVQKF-LEGktIRKVIVVPGKLVNIVV 825
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
4-913 0e+00

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 899.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAKKPFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:TIGR00396   3 HIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  84 SENYALKVKRHPAKQAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTV 163
Cdd:TIGR00396  82 AENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 164 LADEQVVS-GECERCESKVIKKELEQWFFRITNYAERLLKDLEKID-WSEKVKIAQRNWIGRSEGVEIEFKIQNSNLKIK 241
Cdd:TIGR00396 162 LANEQVDSdGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHDEKIT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 242 VFTTRPDTLFGATYMVLSPEHELIGKLesrIKNYQEVKKYIQKARTP------AEDKEKTGVELkGIKAVNPANKEEIPI 315
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLVEKA---AENNPKVAAFIKKILNKtvaertKATKEKKGVDT-GIKAIHPLTGEKIPI 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 316 WVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRradipirsvlmgfdnihseelvslgikevwPADKNHKYI 395
Cdd:TIGR00396 318 WVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVID------------------------------PAEKDLSLT 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 396 Eipenslpafeklirekmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvwnwlpdv 475
Cdd:TIGR00396 368 A------------------------------------------------------------------------------- 368
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 476 pfykelfIHTERGILINSAKFSGMDSEEAKWEITKFVG----GERKVQYRLRDWLISRQRYWGPPIPMIFCEKCNWQPVP 551
Cdd:TIGR00396 369 -------AYTEDGVLVNSGEFNGLNSSEARNAIIDMLEkegkGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVP 441
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 552 EQDLPVKLPYLKDWRPKGTgvSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFSKALARKW 631
Cdd:TIGR00396 442 EEDLPVILPEDVVYDGDGG--SPLSRIPEWVNVTCPSCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYW 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 632 LPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKF--------------------------------RAHGLL 679
Cdd:TIGR00396 520 LPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKKLinqgmvlgfyyppngkvpadvlterdekgkdkAGGELV 599
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 IKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARVQKFEKK---------LASTS 750
Cdd:TIGR00396 600 YVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWNLVYEitgeldaasLTVTA 679
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 751 KEGLAENSERIVHQSIKKITEDIESLR-YNTAVSQLMILSNKLEELPK--VPWAAWEVFLKLLAPFAPYISEELYQKFGK 827
Cdd:TIGR00396 680 LEEAQKELRRDVHKFLKKVTEDLEKREsFNTAISAMMELLNKLYKAKKeaLMLEYLKGFVTVLSPFAPHLAEELWEKLGS 759
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 828 NKSfrkqnSVHLQSWPKYNAKKIKEDVFLLVVQVNGKVRATIQAPVGISEKDAERIALANENVKKYLL-PGLRKTIFVPD 906
Cdd:TIGR00396 760 EPF-----IIDNAKWPVVDETALVEDKTLIVVQVNGKFRAKITVPKDADEEQVEELAKQDPEVKKYLEnKTIKKVIYVPG 834

                  ....*..
gi 1083487655 907 KLINFVV 913
Cdd:TIGR00396 835 KLVNFVI 841
PLN02563 PLN02563
aminoacyl-tRNA ligase
4-913 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 797.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFE-PELGRAKKP-FYNLMMFPYPSAEGLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFG 81
Cdd:PLN02563   82 FHEIEPKWQRYWEENRTFRtPDDVDTSKPkFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFG 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  82 IHSENYALKVKRHPAKQAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCK 161
Cdd:PLN02563  162 LPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALG 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 162 TVLADEQVVSGECERCESKVIKKELEQWFFRITNYAERLLKDLEKIDWSEKVKIAQRNWIGRSEGVEIEFKI-----QNS 236
Cdd:PLN02563  242 TVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVldgegKER 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 237 NLKIKVFTTRPDTLFGATYMVLSPEHELIGKLESRIKNyQEVKKYIQKA-------RTPAEdKEKTGVeLKGIKAVNPAN 309
Cdd:PLN02563  322 DEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQK-EAVEEYVDAAsrksdleRTELQ-KEKTGV-FTGSYAINPAT 398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 310 KEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRADIpirsvlmgfdnihseelvslgikEVWPAD 389
Cdd:PLN02563  399 GEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADG-----------------------NEDDAE 455
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 390 Knhkyieipenslpafeklirekmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaiynnepepkgsvw 469
Cdd:PLN02563  456 K------------------------------------------------------------------------------- 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 470 nwlpdvpfykelfIHTERGILINSA----KFSGMDSEEAKWEITKFV----GGERKVQYRLRDWLISRQRYWGPPIPMIF 541
Cdd:PLN02563  457 -------------AYTGEGVIVNSSssglDINGLSSKEAAKKVIEWLeetgNGKKKVNYKLRDWLFARQRYWGEPIPVVF 523
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 542 CEKCNWQ-PVPEQDLPVKLPYLKDWRPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLDVKNKK 620
Cdd:PLN02563  524 LEDSGEPvPVPESDLPLTLPELDDFTPTGTGEPPLAKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSN 603
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 621 EIFSKALARKWLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVGFREPSKKFRAHGLL--------------------- 679
Cdd:PLN02563  604 ALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCLVNQGMIlgeveytafkdsdgeyvsadt 683
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 -----------------IKDGA-----------------KMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFR 725
Cdd:PLN02563  684 adrlgelqqekipeekvIKSGDsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWS 763
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 726 DSGILGITRFLARV----------QKFEKKLASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEEL 795
Cdd:PLN02563  764 TSGVEGVHRFLGRTwrlvvgaplpDGSFRDGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKW 843
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 796 PKVPWAAWEVFLKLLAPFAPYISEELYQKFGknksfrKQNSVHLQSWPKYNAKKIKEDVFLLVVQVNGKVRATIQAPVGI 875
Cdd:PLN02563  844 DKVPREAIEPFVLLLSPYAPHLAEELWFRLG------HSNSLAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGC 917
                         970       980       990
                  ....*....|....*....|....*....|....*....
gi 1083487655 876 SEKDAERIALANENVKKYLL-PGLRKTIFVPDKLINFVV 913
Cdd:PLN02563  918 SEDDAFALASQDEKLSKYLDgKEIKKRIYVPGKILNVIL 956
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
218-359 1.03e-72

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 237.06  E-value: 1.03e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 218 RNWIGRSEGVEIEFKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHELIGKLEsriKNYQEVKKYIQKARTP------AED 291
Cdd:pfam13603   1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLA---EKNPEVAAFIEECKNTseiertSET 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1083487655 292 KEKTGVeLKGIKAVNPANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAD 359
Cdd:pfam13603  78 KEKEGV-FTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPED 144
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
4-866 5.18e-67

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 240.73  E-value: 5.18e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGI 82
Cdd:TIGR00422   7 PHEVEKKWYKKWEKSGFFKPDGNSNKPPF--CIDIPPPNVTGsLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  83 HSENyalKVKRHPAKQAK----ISEKNFYR---------------QLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFK 143
Cdd:TIGR00422  85 ATQV---KVEKKLGAEGKtkhdLGREEFREkiwewkeesggtiknQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 144 KGLAYRKKQAVNWCPDCKTVLADEQVvsgecerceskvIKKELEQ--WFFRitnyaerllkdlekidwsekvkiaqrnwi 221
Cdd:TIGR00422 162 KGLIYRGEYLVNWDPKLNTAISDIEV------------EYKEVKGklYYIR----------------------------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 222 grsegveieFKIQN-SNLKIKVFTTRPDTLFGATYMVLSPE----HELIGKlesriknyqevkkyiqkartpaedkektg 296
Cdd:TIGR00422 201 ---------YPLANgSKDYLVVATTRPETMFGDTAVAVHPEderyKHLIGK----------------------------- 242
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 297 velkgiKAVNPANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAdipirsvlmGFDNIHSEE 376
Cdd:TIGR00422 243 ------KVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED---------GLLNENAGK 307
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 377 LVSLGIKEvwpadknhkyieipenslpAFEKLIREKMTPGFWNEYITH-QRVIFIFKDKNgLVERLeLTPgtdnkinrls 455
Cdd:TIGR00422 308 YQGLTRFE-------------------ARKKIVEDLKEEGLLVKIEPHtHNVGTCWRSGT-VVEPL-LSK---------- 356
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 456 aiynnepepkgsvwNWLPDVPfykelfihtergILINSAKfsgmdsEEAKWEITKFVGGERKVQYR-----LRDWLISRQ 530
Cdd:TIGR00422 357 --------------QWFVKVE------------KLADKAL------EAAEEGEIKFVPKRMEKRYLnwlrnIKDWCISRQ 404
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 531 RYWGPPIPMIFCEKCNWQPVPEQDLPVKLPYLkdwrpkgtgvsplaseskfykvkcPKCNGEARRETDVSDTFLDSAWYF 610
Cdd:TIGR00422 405 LIWGHRIPVWYCKECGEVYVAKEEPLPDDKTN------------------------TGPSVELEQDTDVLDTWFSSSLWP 460
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 611 FRYLDVKNKKEIFskalaRKWLPVDMYIGGaeHAVLHLLYVRFITKVFADLGLVgfrePSKKFRAHGLLI-KDGAKMSKS 689
Cdd:TIGR00422 461 FSTLGWPDETKDL-----KKFYPTDLLVTG--YDIIFFWVARMIFRSLALTGQV----PFKEVYIHGLVRdEQGRKMSKS 529
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 690 RGNVVSPDTYIKKFGADALRMYLMFLGPfdQGGDFR------DSG------ILGITRFLARVQKFEKKLASTskEGLAEN 757
Cdd:TIGR00422 530 LGNVIDPLDVIEKYGADALRFTLASLVT--PGDDINfdwkrvESArnflnkLWNASRFVLMNLSDDLELSGG--EEKLSL 605
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 758 SER-IVH---QSIKKITEDIESLRYNTAVSQLM------------------ILSNKLEELPKVPWAAWEVF---LKLLAP 812
Cdd:TIGR00422 606 ADRwILSklnRTIKEVRKALDKYRFAEAAKALYefiwndfcdwyielvkyrLYNGNEAEKKAARDTLYYVLdkaLRLLHP 685
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 813 FAPYISEELYQKFGKnksfrKQNSVHLQSWPKYNAKKIKEDV---FLLVVQVNGKVR 866
Cdd:TIGR00422 686 FMPFITEEIWQHFKE-----GADSIMLQSYPVVDAEFVDEEAekaFELLKEIIVSIR 737
valS PRK13208
valyl-tRNA synthetase; Reviewed
7-866 9.44e-59

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 215.83  E-value: 9.44e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   7 IEKKWNALWRKTGVFEPELGRAKK-------PfynlmmfPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDG 79
Cdd:PRK13208   15 LEEKWQKIWEEEGTYKFDPDERKPvysidtpP-------PTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDD 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  80 FGIHSE----NYaLKVKRHPAKQAK----------ISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKG 145
Cdd:PRK13208   87 NGLPTErkveKY-YGIRKDDISREEfielcreltdEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 146 LAYRKKQAVNWCPDCKTVLADeqvvsGECERceskvikKELEQWFFRItnyaerllkdlekidwseKVKIAQrnwigrSE 225
Cdd:PRK13208  166 LIYRAEAPVLWCPRCETAIAQ-----AEVEY-------REREGKLNYI------------------KFPVED------GE 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 226 GVEIEfkiqnsnlkikvfTTRPDtLFGATY-MVLSPEHE----LIGKlesriknyqevkkyiqKARTPAEDKEktgVELK 300
Cdd:PRK13208  210 EIEIA-------------TTRPE-LLPACVaVVVHPDDErykhLVGK----------------TAIVPLFGVE---VPIL 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 301 GIKAVNPaNKeeipiwvadyvlggvGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRAdipirsvlmGFDNIHSEELVSL 380
Cdd:PRK13208  257 ADPLVDP-DF---------------GTGAVMICTFGDKTDVTWWRELNLPTRIIIDED---------GRMTEAAGKLAGL 311
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 381 GIKEvwpADKnhKYIEIpensLPAFEKLIREK----MTPGFWN-----EYITHqRVIFI----FKDKngLVERLeltpgt 447
Cdd:PRK13208  312 TIEE---ARK--KIVED----LKSGGLLGKQEpikhNVKFCERcdtplEILVT-RQWFIkvldLKEE--LLERG------ 373
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 448 dNKInrlsaiynnepepkgsvwNWLPDvpFYKElfihtergILINSAKfsGMDseeakWeitkfvggerkvqyrlrDWLI 527
Cdd:PRK13208  374 -KEI------------------NWYPE--HMRV--------RLENWIE--GLN-----W-----------------DWCI 400
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 528 SRQRYWGPPIPMIFCEKCNwQPVP--EQDLPVKlpylkdwrpkgtgvsPLASESKFYkvKCPKCN-GEARRETDVSDTFL 604
Cdd:PRK13208  401 SRQRYFGTPIPVWYCKDCG-HPILpdEEDLPVD---------------PTKDEPPGY--KCPQCGsPGFEGETDVMDTWA 462
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 605 DSA--------WyffrYLDVKNKKEIFSKALA-------RKWLpvdmyiggaehavlhllyvrFITKVFADLgLVGfREP 669
Cdd:PRK13208  463 TSSitplivtgW----ERDEDLFEKVFPMDLRpqghdiiRTWL--------------------FYTILRAYL-LTG-KLP 516
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 670 SKKFRAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRmYLMFLGPfdQGGDFR-DSGILGITRFLAR----VQKFE 743
Cdd:PRK13208  517 WKNIMISGMvLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YWAASAR--LGSDTPfDEKQVKIGRRLLTklwnASRFV 593
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 744 KKLASTSKEGLAENSERI-------VHQSIKKITEDIESLRYNTAVSQL--------------MI---LSNKLEELPKVp 799
Cdd:PRK13208  594 LHFSADPEPDKAEVLEPLdrwilakLAKVVEKATEALENYDFAKALEEIesffwhvfcddyleLVksrAYGEDEEEEQK- 672
                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 800 wAAW-------EVFLKLLAPFAPYISEELYQKFGKnksfrkqNSVHLQSWPKYNAKKIKED---VFLLVVQVNGKVR 866
Cdd:PRK13208  673 -SARytlytvlDTLLRLLAPFLPFITEEVWSWLYG-------GSVHRASWPEPDEELIDEEdeeLGELAKEILSAVR 741
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
32-222 2.12e-52

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 185.91  E-value: 2.12e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  32 FYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQAKISEKNFYRQLG 111
Cdd:cd00812     2 FYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 112 MIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCpdcktvladeqvvsgecerceskvikKELEQWFF 191
Cdd:cd00812    81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWFL 134
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1083487655 192 RI--TNYAERLLKDLEKID-WSEKVKIAQRNWIG 222
Cdd:cd00812   135 KYseTEWKEKLLKDLEKLDgWPEEVRAMQENWIG 168
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
10-712 2.40e-49

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 184.92  E-value: 2.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  10 KWNALWRKTGVFEPELGRAK-KPFYNLMMFPyPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSE-- 85
Cdd:pfam00133   1 QIYEFWDEQGYFKPELEKRKgKPSFTIHDGP-PNATGsLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEqv 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  86 -------------------NYALKVKRHPAKQAKISEKNFYRqlgmIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGL 146
Cdd:pfam00133  80 vekklgikekktrhkygreEFREKCREWKMEYADEIRKQFRR----LGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 147 AYRKKQAVNWCPDCKTVLADEQVvsgecercESKVIKKELeqWFFRITnyaerlLKDLEKIdwsekvkiaqrnwigrseg 226
Cdd:pfam00133 156 IYRGKKLVNWSPALNTALSNLEV--------EYKDVKGPS--IHVAFP------LADDEGA------------------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 227 veiefkiqnsnlKIKVFTTRPDTLFGATYMVLSPEHELIGKLESRIKNYQEVKKYIQKARTPAEDKEKTGVELKGIKAVN 306
Cdd:pfam00133 201 ------------SLVIWTTTPWTLPGNTAVAVNPEFDYVITGEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIH 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 307 PANKEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLP-IKPVirradipirsvlmGFDNIHSEELVSLGIKEV 385
Cdd:pfam00133 269 PFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEvINPV-------------DDDGTFTEEAPDFQGVYR 335
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 386 WPADKnhKYIEIPENsLPAFEKLIREKMTPGF-WNE------YITHQRVIFIFKDKNGLVERLELTpgtdnkinrlsaiy 458
Cdd:pfam00133 336 FDARK--KIVELLTE-KGLLLKIEPFTHSYPFcWRSgtpiipRATPQWFVRMDELADQALEAVEKV-------------- 398
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 459 nnepepkgsvwNWLPDvpFYKELFIHTERGIlinsakfsgmdseeakweitkfvggerkvqyrlRDWLISRQRYWGPPIP 538
Cdd:pfam00133 399 -----------QFVPK--SGEKRYFNWLANI---------------------------------QDWCISRQRWWGHPIP 432
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 539 MifcekcnWQPVPEQDLPVKLPYLKDWRPKGTGVSPLASESKFYKVKCPKCNGEARRETDVSDTFLDSAWYFFRYLD--V 616
Cdd:pfam00133 433 A-------WVSKDTEEVVCRGELFELVAGRFEEEGSIKWLHREAKDKLGYGKGTLEQDEDVLDTWFSSGSWPFSTLGwpF 505
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 617 KNKKEIfskalaRKWLPVDMYIGGAEhavlhLLYVRFITKVFADLGLVGfREPSKKFRAHGLLI-KDGAKMSKSRGNVVS 695
Cdd:pfam00133 506 VNTEEF------KKFFPADMLLEGSD-----QTRGWFYRMIMLSTALTG-SVPFKNVLVHGLVRdEQGRKMSKSLGNVID 573
                         730
                  ....*....|....*..
gi 1083487655 696 PDTYIKKFGADALRMYL 712
Cdd:pfam00133 574 PLDVIDKYGADALRLWL 590
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
522-724 2.03e-47

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 171.66  E-value: 2.03e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 LRDWL-ISRQRYWGPPIPMifcekcnwqpvpeqdlpvklpylkdwrpkgtgvsplaseskfykvkcpkcngearreTDVS 600
Cdd:cd00812   163 QENWIgCSRQRYWGTPIPW---------------------------------------------------------TDTM 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 601 DTFLDSAWYFFRYLDVKN------KKEIFSKALARKWLPVDMYIGGAEHAVLHLLYVRFITKVFADLGLVgFREPSKKFR 674
Cdd:cd00812   186 ESLSDSTWYYARYTDAHNleqpyeGDLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLI 264
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1083487655 675 AHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF 724
Cdd:cd00812   265 VQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
ileS TIGR00392
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ...
4-873 4.60e-46

isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273054 [Multi-domain]  Cd Length: 861  Bit Score: 178.34  E-value: 4.60e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNALWRKTGVFEPELGRAK-KPFYNLMMFPyPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLD--- 78
Cdd:TIGR00392   8 LSKREEKILAFWQENDIFEKVKKLNKgKPEFIFHDGP-PYANGsIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDthg 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  79 ---------GFGIHS---------ENYALKVKRHPAKQAKISEKNFYRqLGMIGNgfaWKEKLETYDPEYYKWTQWIFVQ 140
Cdd:TIGR00392  87 lpiehkvekKLGISGkkeissleiEEFREKCREFALKQIEEQREQFQR-LGVWGD---WENPYKTMDPSYEESQWWLFKE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 141 MFKKGLAYRKKQAVNWCPDCKTVLADEQVVSGECERCEskvikkeleqwffritnyaerllkdlekidwsekvkiaqrnw 220
Cdd:TIGR00392 163 AHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYKDV------------------------------------------ 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 221 igRSEGVEIEFKIQNSNLK--------IKVFTTRPDTLFGATYMVLSPEHE-----LIGKLESRIKNYQEVKKYIQKART 287
Cdd:TIGR00392 201 --KDPSIYVKFPVKKDKKTylkvklssLLIWTTTPWTLPSNLAIAVHPDFEyalvqDNTKVEYFILAKKLVEKLYNKAGS 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 288 PAEDKEK-TGVELKGIKAVNPAN------KEEIPIWV-ADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIkpvirrad 359
Cdd:TIGR00392 279 DYEIIKTfKGSDLEGLEYEHPLYdfvsqlKEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEV-------- 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 360 ipirsvLMGFD--NIHSEELVSLGIKEVWPADKNhkyieipensLPAFEKLIREKMtpgfwneyithqrvififKDKNGL 437
Cdd:TIGR00392 351 ------LSPVDekGVYTEGVNDFQGRFVKDADKD----------IIKANKIIIEQL------------------KDKGLL 396
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 438 VerleltpgtdnkinRLSAIYNNEPepkgsvWNWLPDVP--FY--KELFIHTE--RGILINSAKFSGMDSEEAKWEITKF 511
Cdd:TIGR00392 397 L--------------KAEKITHSYP------HCWRTKTPviYRatEQWFIKTKdiKDQMLEQIKKVNWVPEWGEGRFGNW 456
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 512 VGGerkvqyrLRDWLISRQRYWGPPIPMIFCEKCNwQP-----VPEQDLPVKLPYLKDWRPKgtGVSPLASESKFykvKC 586
Cdd:TIGR00392 457 LEN-------RPDWCISRQRYWGIPIPIWYCEDTG-EPivvgsIEELIELIELKGIDAWFED--LHRDFLDKITL---KS 523
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 587 PKCnGEARRETDVSDTFLDSAWYFFRYLDVKNKKEIFskalaRKWLPVDMYIGGAEHA-----VLHLLYVRFITKVfadl 661
Cdd:TIGR00392 524 GDG-GEYRRVPDVLDVWFDSGSMPYASIHYPFENEKF-----KEVFPADFILEGSDQTrgwfySSLAIGTALFGQA---- 593
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 662 glvgfrePSKKFRAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGP-----FDQGG--DFRDS--GILG 731
Cdd:TIGR00392 594 -------PYKNVITHGFtLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSDPwedlrFSDEIlkQVVEKyrKIRW 666
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 732 IT-RFL---ARVQKFEKKLASTSKEGLAENSERIVHQS---IKKITEDIESLRYNTAVSQLM-----ILSNKLEELPK-- 797
Cdd:TIGR00392 667 NTyRFLltyANLDKFDPLFNSVAVEKFPEEDRWILSRLnslVEEVNEALEKYNFHKVLRALQdfiveELSNWYIRIIRdr 746
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 798 ---------------VPWAAWEVFLKLLAPFAPYISEELYQ--KFGKNKSfrkqnSVHLQSWPKYNAK----------KI 850
Cdd:TIGR00392 747 lyceakdndkraaqtTLYYALLTLVRLLAPFLPHTAEEIYQnlPGGEEEE-----SVHLNLWPEVDEEfidealeanmAI 821
                         970       980
                  ....*....|....*....|...
gi 1083487655 851 KEDVFLLVVQVNGKVRATIQAPV 873
Cdd:TIGR00392 822 VREIVEAFLALRDAANKKLRQPL 844
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
2-853 1.46e-42

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 167.95  E-value: 1.46e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   2 AGFSRIEKKWNALWRKTGVFEP--ELGRAKKPFYnlmmF---PyPSAEGL-HVGnmYAFVGS--DIYGRFQRMRGNDVFE 73
Cdd:COG0060    16 ANLPKREPEILKFWEENDIYEKsrEARAGRPKFV----LhdgP-PYANGDiHIG--HALNKIlkDIIVRYKTMRGFDVPY 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  74 ---------PI--------GLDGFGIHS----------ENYALKvkrhpakQAKISEKNFYRqLGMIGNgfaWKEKLETY 126
Cdd:COG0060    89 vpgwdchglPIelkvekelGIKKKDIEKvgiaefrekcREYALK-------YVDEQREDFKR-LGVWGD---WDNPYLTM 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 127 DPEYYK--WtqWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEqvvsgecerceskvikkELEqwffritnYAER----- 199
Cdd:COG0060   158 DPEYEEsiW--WALKKLYEKGLLYKGLKPVPWCPRCGTALAEA-----------------EVE--------YKDVtspsi 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 200 ----LLKDLEKIDWSEKVKIAqrnwigrsegveiefkiqnsnlkikVFTTRPDTLFG------------ATYMVLSPEH- 262
Cdd:COG0060   211 yvkfPVKDEKALLLLEDAYLV-------------------------IWTTTPWTLPAnlavavhpdidyVLVEVTGGERl 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 263 ----ELIGKL--ESRIKNYQEVKKYiqkartpaedkekTGVELKGIKAVNP-----ANKEEIPIWVADYVLGGVGTGAI- 330
Cdd:COG0060   266 ilaeALVEAVlkELGIEDYEVLATF-------------KGAELEGLRYEHPfyyvvGYDRAHPVILGDYVTTEDGTGIVh 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 331 MAvPAHDERDFEFAKKFKLPIKPVIR-----RADIPirsvlmGFDNIHseelvslgikeVWPADKnhkyiEIPENsLPAF 405
Cdd:COG0060   333 TA-PGHGEDDFEVGKKYGLPVLNPVDddgrfTEEAP------LFAGLF-----------VKDANP-----AIIED-LKER 388
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 406 EKLIREKMtpgfwneyITHQ-----R----VI-------FI----FKDKnglverleltpgtdnkinrlsAIYNNEpepk 465
Cdd:COG0060   389 GALLAREK--------ITHSyphcwRcktpLIyratpqwFIsmdkLRDR---------------------ALEAIE---- 435
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 466 gSVwNWLPDvpfYKElfihtERgilinsakfsgmdseeakweITKFVGGerkvqyrLRDWLISRQRYWGPPIPMIFCEKC 545
Cdd:COG0060   436 -KV-NWIPE---WGE-----GR--------------------FGNMLEN-------RPDWCISRQRYWGVPIPIWVCEDC 478
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 546 NWQPVPE------------------QDLPVKLPYLKDwrpkgtgvsplaseskfyKVKCPKCNGEARRETDVSDTFLDS- 606
Cdd:COG0060   479 GELHRTEevigsvaelleeegadawFELDLHRPFLDE------------------TLKCPKCGGTMRRVPDVLDVWFDSg 540
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 607 -AWYFfrylDVKNKKEifskalarKWLPVDMYI-GGAEHA----VLHLLYVrfitkvfadlGLVGfREPSKKFRAHGL-L 679
Cdd:COG0060   541 sMHFA----VLENREE--------LHFPADFYLeGSDQTRgwfySSLLTST----------ALFG-RAPYKNVLTHGFvL 597
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 680 IKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLgpfDQGGDFR-DSGILGITR------------FLARVQKFEKKL 746
Cdd:COG0060   598 DEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASS---DYWGDLRfSDEILKEVRdvyrrlrntyrfLLANLDDFDPAE 674
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 747 ASTSKEGLAEnSER-IVH---QSIKKITEDIESLRYNTAVSQLMI-----LSN-------------KLEELPKVpwAA-- 802
Cdd:COG0060   675 DAVPYEDLPE-LDRwILSrlnELIKEVTEAYDNYDFHRAYRALHNfcvedLSNwyldiskdrlyteAADSLDRR--AAqt 751
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1083487655 803 --WEVF---LKLLAPFAPYISEELYQKFGKNKSfrkqNSVHLQSWPKYNAKKIKED 853
Cdd:COG0060   752 tlYEVLetlVRLLAPILPFTAEEIWQNLPGEAE----ESVHLADWPEVDEELIDEE 803
valS PRK14900
valyl-tRNA synthetase; Provisional
7-896 2.00e-36

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 148.99  E-value: 2.00e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655    7 IEKKWNALWRKTGVFE-PELGRAKKPFYnlMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRG-NDVFEPiGLDGFGIH 83
Cdd:PRK14900    24 VEARWYPFWQERGYFHgDEHDRTRPPFS--IVLPPPNVTGsLHLGHALTATLQDVLIRWKRMSGfNTLWLP-GTDHAGIA 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   84 SEnyaLKVKRHPAKQAKISEKNFYRQlGMIGNGFAWKEKLE---------------------TYDPEYYKWTQWIFVQMF 142
Cdd:PRK14900   101 TQ---MIVEKELKKTEKKSRHDLGRE-AFLERVWAWKEQYGsrigeqhkalgasldwqrerfTMDEGLSRAVREVFVRLH 176
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  143 KKGLAYRKKQAVNWCPDCKTVLADEQVVSGECerceskvikKELEQWFFRitnyaerllkdlekidwsekvkiaqrnwig 222
Cdd:PRK14900   177 EEGLIYREKKLINWCPDCRTALSDLEVEHEEA---------HQGELWSFA------------------------------ 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  223 rsegveieFKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHEligklesrikNYQevkkyiqkartpaedkektgvELKGI 302
Cdd:PRK14900   218 --------YPLADGSGEIVVATTRPETMLGDTAVAVHPLDP----------RYM---------------------ALHGK 258
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  303 KAVNPANKEEIPIwVADYVL--GGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIrradipirsvlmGFDNIHSEELVSL 380
Cdd:PRK14900   259 KVRHPITGRTFPI-VADAILvdPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVI------------GPDGRMTAEAGPL 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  381 GIKEVWPADKNHKYIeIPENSLPAFEKliREKMTPGfwneyiTHQRVIFIFkdknglverleltpgtdnkinrlsaiynn 460
Cdd:PRK14900   326 AGLDRFEARKEVKRL-LAEQGLDRGAK--PHVLPLG------RCQRSATIL----------------------------- 367
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  461 epEPKGSVWNWLPDVPFYKELFIHTERGilinsakfsgmdseeakweITKFVGGERKVQY-----RLRDWLISRQRYWGP 535
Cdd:PRK14900   368 --EPLLSDQWYVRIEPLARPAIEAVEQG-------------------RTRFIPEQWTNTYmawmrNIHDWCISRQLWWGH 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  536 PIPMIFCekcnwqpvpeqdlPVKLPYLKDWRPKGtgvsplaseskfykvkCPKCNG-EARRETDVSDTFLDSAWYFFRYL 614
Cdd:PRK14900   427 QIPAWYC-------------PDGHVTVARETPEA----------------CSTCGKaELRQDEDVLDTWFSSGLWPFSTM 477
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  615 D-VKNKKEIfskalaRKWLPVDMYIGGaeHAVLHLLYVRFITKVFADLGLVGFRepskKFRAHGlLIKD--GAKMSKSRG 691
Cdd:PRK14900   478 GwPEQTDTL------RTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEVPFR----TVYLHP-MVRDekGQKMSKTKG 544
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  692 NVVSPDTYIKKFGADALRMYLMFLGPfdQGGDFRDS------------GILGITRF-LARVQKFEKKLASTSKEGLAENS 758
Cdd:PRK14900   545 NVIDPLVITEQYGADALRFTLAALTA--QGRDIKLAkeriegyrafanKLWNASRFaLMNLSGYQERGEDPARLARTPAD 622
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  759 ERIVHQSIKKITEDIESL---RYNTAVSQLMI-----LSNKLEELPKVPWA----------------AWEVFLKLLAPFA 814
Cdd:PRK14900   623 RWILARLQRAVNETVEALeafRFNDAANAVYAfvwheLCDWYIELAKEALAsedpearrsvqavlvhCLQTSYRLLHPFM 702
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  815 PYISEELYQKFGKNKSFRK-QNSVHLQSWPKYNA-KKIKEDVFLLVV-------------QVNGKVRATIQAPVGISEKD 879
Cdd:PRK14900   703 PFITEELWHVLRAQVGASAwADSVLAAEYPRKGEaDEAAEAAFRPVLgiidavrnirgemGIPWKVKLGAQAPVEIAVAD 782
                          970
                   ....*....|....*..
gi 1083487655  880 AERIALANENVKKYLLP 896
Cdd:PRK14900   783 PALRDLLQAGELARVHR 799
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
46-854 5.02e-36

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 147.32  E-value: 5.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  46 LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGldgF--------GIhsenyALKVKRHPAKQAKISeKNFY---------- 107
Cdd:PRK12300    1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMA---FhvtgtpilGI-----AERIARGDPETIELY-KSLYgipeeelekf 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 108 ---------------RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVSG 172
Cdd:PRK12300   72 kdpeyiveyfseeakEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 173 EcerceskviKKELEQWffritnyaerllkdlekidwsekvkiaqrnwigrsegVEIEFKiQNSNLKIKVFTTRPDTLFG 252
Cdd:PRK12300  152 E---------EPEIVEY-------------------------------------TLIKFE-ESEDLILPAATLRPETIFG 184
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 253 ATYMVLSPEHE-LIGKLESR--IKNYQEVKKYIQKARTPAEDKEKTGVELKGIKAVNPANKEEIPIWVADYVLGGVGTGA 329
Cdd:PRK12300  185 VTNLWVNPDATyVKAEVDGEkwIVSKEAAEKLSFQDRDVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGV 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 330 IMAVPAHDE------RDFEFAKKFKLPIKPvirradIPIRSVlMGFDNIHSEELV-SLGIKEvwPADknhkyieipensl 402
Cdd:PRK12300  265 VMSVPAHAPydyvalRDLKKNKELLDVIEP------IPLIEV-EGYGEFPAKEVVeKLGIKS--QED------------- 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 403 PAFEKLIREkmtpgfwneyithqrvififkdknglverleltpgtdnkinrlsaIYNNEpepkgsvwnwlpdvpFYKelf 482
Cdd:PRK12300  323 PELEEATKE---------------------------------------------VYRAE---------------FHK--- 339
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 483 ihterGILI-NSAKFSGMDSEEAKWEITKF-----VGG------ERKVQYR---------LRD-WLIsrqRYwGPPIPMI 540
Cdd:PRK12300  340 -----GVLKeNTGEYAGKPVREAREKITKDliekgIADimyefsNRPVYCRcgtecvvkvVKDqWFI---DY-SDPEWKE 410
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 541 FCEKC--NWQPVPE---QDLPVKLPYLKDW---RPKGTG----------VSPLaSESKFY--------KVKCPKCNGEar 594
Cdd:PRK12300  411 LAHKAldNMEIIPEeyrKEFENTIDWLKDRacaRRRGLGtrlpwdeewiIESL-SDSTIYmayytiahKIREYGIKPE-- 487
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 595 retDVSDTFLDsawYFFryLDVKNKKEIFSKAL--------ARK----WLPVDMYIGGAEHAVLHLLYvrFItkvFADLG 662
Cdd:PRK12300  488 ---QLTPEFFD---YVF--LGKGDPEEVSKKTGipkeileeMREeflyWYPVDWRHSGKDLIPNHLTF--FI---FNHVA 554
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 663 LvgFREpSKKFRA---HGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGITRFLARV 739
Cdd:PRK12300  555 I--FPE-EKWPRGivvNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERF 631
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 740 QKFEKKLASTSKEGLAENSER----IVHQSIKKITEDIESLRYNTAVsQLMI--LSNKL--------EELPKVPWAAWEV 805
Cdd:PRK12300  632 YELAKELIEIGGEEELRFIDKwllsRLNRIIKETTEAMESFQTRDAV-QEAFyeLLNDLrwylrrvgEANNKVLREVLEI 710
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*....
gi 1083487655 806 FLKLLAPFAPYISEELYQKFGKnKSFrkqnsVHLQSWPKYNAKKIKEDV 854
Cdd:PRK12300  711 WIRLLAPFTPHLAEELWHKLGG-EGF-----VSLEKWPEPDESKIDEEA 753
valS PRK05729
valyl-tRNA synthetase; Reviewed
7-889 8.25e-36

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 146.40  E-value: 8.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   7 IEKKWNALWRKTGVFEPElGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDV-FEPiGLDGFGIHS 84
Cdd:PRK05729   14 VEAKWYQKWEEKGYFKPD-DNSKKPF--SIVIPPPNVTGsLHMGHALNNTLQDILIRYKRMQGYNTlWLP-GTDHAGIAT 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  85 ENyalKVKRHPAKQ-------------AKISE-KNFY-----RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKG 145
Cdd:PRK05729   90 QM---VVERQLAAEgksrhdlgrekflEKVWEwKEESggtitNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 146 LAYRKKQAVNWCPDCKTVLADEQVvsgecercESKVIKKELeqWFFRitnYaerllkdlekidwsekvkiaqrnwigrse 225
Cdd:PRK05729  167 LIYRGKRLVNWDPKLQTALSDLEV--------EYKEVKGKL--WHIR---Y----------------------------- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 226 gveiefKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHE----LIGKlesriknyqevkkyiqkartpaedkektgvelkg 301
Cdd:PRK05729  205 ------PLADGSDYLVVATTRPETMLGDTAVAVNPEDErykhLIGK---------------------------------- 244
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 302 iKAVNPANKEEIPIwVAD-YVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVI-RRADIpirsvlmgfdNIHSEELVS 379
Cdd:PRK05729  245 -TVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMdEDGTI----------NENPGEYQG 312
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 380 LgikevwpaDKnhkyieipenslpaFE--KLIREKMtpgfwneyithqrvififkDKNGLVERLEltpgtDNKIN----- 452
Cdd:PRK05729  313 L--------DR--------------FEarKAIVADL-------------------EELGLLVKIE-----PHTHSvghsd 346
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 453 --------RLS-------------AIYNNEpepKGsvwnwlpDVPFYKELFIHTERGILINsakfsgmdseeakweitkf 511
Cdd:PRK05729  347 rsgvviepYLSdqwfvkmkplakpALEAVE---NG-------EIKFVPERWEKTYFHWMEN------------------- 397
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 512 vggerkvqyrLRDWLISRQRYWGPPIPMIFCEKCNWQpVPEQDlpvklpylkdwrpkgtgvsplaseskfykvkcPKCNG 591
Cdd:PRK05729  398 ----------IQDWCISRQLWWGHRIPAWYDEDGEVY-VGREE--------------------------------PEARE 434
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 592 EA--RRETDVSDTfldsaWyffryldvknkkeiFSKALA--------------RKWLPVD---------------MYIGG 640
Cdd:PRK05729  435 KAllTQDEDVLDT-----W--------------FSSALWpfstlgwpektedlKRFYPTSvlvtgfdiiffwvarMIMMG 495
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 641 aehavLHllyvrFITKV-FADLGLvgfrepskkfraHGlLIKD--GAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGP 717
Cdd:PRK05729  496 -----LH-----FTGQVpFKDVYI------------HG-LVRDeqGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALAS 552
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 718 fdQGGDFR------DSG------ILGITRFlARVQKFEKKLASTSKEGLAENSER-IVH---QSIKKITEDIESLRYNTA 781
Cdd:PRK05729  553 --PGRDIRfdeervEGYrnfankLWNASRF-VLMNLEGADVGELPDPEELSLADRwILSrlnRTVAEVTEALDKYRFDEA 629
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 782 VSQL--------------MI---LSNKLEELPK-VPWAAWEVFLKLLAPFAPYISEELYQKFgknKSFRKQNSVHLQSWP 843
Cdd:PRK05729  630 ARALyefiwnefcdwyleLAkpvLQEAAKRATRaTLAYVLEQILRLLHPFMPFITEELWQKL---APLGIEESIMLAPWP 706
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 844 KYNAKKIKEDV--FLLVVQVNGKVR---------ATIQAPVGISEKDAERIALANEN 889
Cdd:PRK05729  707 EADEAIDEAAEaeFEWLKELITAIRniraemnipPSKKLPLLLKGADAEDRARLEAN 763
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
7-889 4.79e-33

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 137.49  E-value: 4.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   7 IEKKWNALWRKTGVFEPELGRAKKPFYnlMMFPYPSAEG-LHVGnmYAFVGS--DIYGRFQRMRGNDV-FEPiGLDGFGI 82
Cdd:COG0525    12 VEAKWYQYWEENGYFKADPDSDKEPFT--IVIPPPNVTGsLHMG--HALNNTlqDILIRYKRMQGYNTlWQP-GTDHAGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  83 HSENyalKVKRHPAKQ-------------AKISE-KNFY-----RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFK 143
Cdd:COG0525    87 ATQA---VVERQLAEEgksrhdlgrekflERVWEwKEESggtitNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 144 KGLAYRKKQAVNWCPDCKTVLADEQVvsgecercESKVIKKELeqWFFRitnYaerllkdlekidwsekvkiaqrnwigr 223
Cdd:COG0525   164 KGLIYRGKRLVNWDPKLKTALSDLEV--------EHEEVKGHL--WHIR---Y--------------------------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 224 segveiefKIQNSNLKIKVFTTRPDTLFGATYMVLSPEHE----LIGKlesriknyqevkkyiqkartpaedkektgvel 299
Cdd:COG0525   204 --------PLADGSGYIVVATTRPETMLGDTAVAVHPEDErykhLIGK-------------------------------- 243
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 300 kgiKAVNPANKEEIPIwVAD-YVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIkpvirradIPIrsvlMGFD---NIHSE 375
Cdd:COG0525   244 ---TVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPM--------INI----LDEDgtiNENAG 307
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 376 ELVslGikevwpadknhkyieipensLPAFE--KLIREKMtpgfwneyithqrvififkDKNGLVERLEltpgtDNKIN- 452
Cdd:COG0525   308 KYR--G--------------------LDRFEarKAIVADL-------------------EELGLLVKVE-----PHKHSv 341
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 453 ----RLSAIYnnepEPkgsvwnWLPDVPF--YKELfihTERGIlinsakfsgmdseEA-KWEITKFVGgER--KVqYR-- 521
Cdd:COG0525   342 ghsdRSGTVI----EP------YLSDQWFvkMKPL---AKPAI-------------EAvEDGEIKFVP-ERweKT-YFhw 393
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 ---LRDWLISRQRYWGPPIPMIFCEKcNWQPVPEQDLPVklpylkdwrpkgtgvsplaseskfykvkCPKCNGEA-RRET 597
Cdd:COG0525   394 menIRDWCISRQLWWGHRIPAWYCPD-GEVYVARTEPEA----------------------------CAKAGSVNlTQDE 444
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 598 DVSDTfldsaWyffryldvknkkeiFSKALarkWlPvdmyiggaehavlhllyvrfitkvFADLG--------------- 662
Cdd:COG0525   445 DVLDT-----W--------------FSSAL---W-P------------------------FSTLGwpektedlkyfypts 477
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 663 -LV-GF-------------------REPskkFRA---HGLlIKD--GAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLG 716
Cdd:COG0525   478 vLVtGFdiiffwvarmimmglhftgEVP---FKDvyiHGL-VRDeqGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALA 553
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 717 PfdQGGDFR------DSG------ILGITRF-LARVQKFEKKLASTSKEGLAEN----SEriVHQSIKKITEDIESLRYN 779
Cdd:COG0525   554 S--PGRDIKfdeervEGYrnfankLWNASRFvLMNLEGFDPGLDPDPEELSLADrwilSR--LNKTIAEVTEALEKYRFD 629
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 780 TAVSQL--------------MI---LSNK-LEELPKVPWAAWEVF---LKLLAPFAPYISEELYQKFGKNKSfrkQNSVH 838
Cdd:COG0525   630 EAAQALydfvwnefcdwyleLAkprLYGGdEAAKRETRATLVYVLeqiLRLLHPFMPFITEEIWQKLPPRKE---GESIM 706
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1083487655 839 LQSWPKYNAKKIKEDV---FLLVVQVNGKVRaTIQAPVGISEKDAERIALANEN 889
Cdd:COG0525   707 LAPWPEADEELIDEEAeaeFEWLKEVISAIR-NIRAEMNIPPSKKLPLLLKGAD 759
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
36-221 3.18e-28

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 117.73  E-value: 3.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  36 MMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENyalKVKRHPAKQAKI------------- 101
Cdd:cd00817     5 IDTPPPNVTGsLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQV---VVEKKLGIEGKTrhdlgreeflekc 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 102 ------SEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVvsgeCE 175
Cdd:cd00817    82 wewkeeSGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----CS 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1083487655 176 RCESKVIKKELEQWFFRITNYAERLLKDLEK--IDWS-EKVKIAQRNWI 221
Cdd:cd00817   158 RSGDVIEPLLKPQWFVKVKDLAKKALEAVKEgdIKFVpERMEKRYENWL 206
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
726-825 4.85e-28

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 109.23  E-value: 4.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 726 DSGILGITRFLARVQKF-----EKKLASTSKEGLAENSE---RIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEELPK 797
Cdd:cd07958     3 DSGVEGAYRFLNRVWRLvtelaEALAAPAAAAELSEEDKelrRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKYKK 82
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1083487655 798 -------VPWAAWEVFLKLLAPFAPYISEELYQKF 825
Cdd:cd07958    83 kdaqhaaVLREALETLVLLLAPFAPHIAEELWEEL 117
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
522-725 4.43e-23

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 102.32  E-value: 4.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 LRDWLISRQRYWGPPIPMIFCEKCN-WQPVPEQDLPVKLPylkdwrpkgtgvsplaseskFYKVKCPKCNGEARRETDVS 600
Cdd:cd00817   209 IRDWCISRQLWWGHRIPAWYCKDGGhWVVAREEDEAIDKA--------------------APEACVPCGGEELKQDEDVL 268
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 601 DTFLDSAWYFFRYLDVKNKKEIFskalaRKWLPVDMYIGGaeHAVLH--LLYVRFITKVFADlglvgfREPSKKFRAHGL 678
Cdd:cd00817   269 DTWFSSSLWPFSTLGWPEETKDL-----KKFYPTSLLVTG--HDIIFfwVARMIMRGLKLTG------KLPFKEVYLHGL 335
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1083487655 679 LI-KDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPfdQGGDFR 725
Cdd:cd00817   336 VRdEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAAT--QGRDIN 381
PLN02943 PLN02943
aminoacyl-tRNA ligase
4-894 3.13e-22

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 103.10  E-value: 3.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   4 FSRIEKKWNaLWRKTGVFEPELGRAKKPFYNLMmfPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGI 82
Cdd:PLN02943   63 FTSEERIYN-WWESQGYFKPNFDRGGDPFVIPM--PPPNVTGsLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  83 HSEnyaLKVKRHPA----KQAKISEKNFYR---------------QLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFK 143
Cdd:PLN02943  140 ATQ---LVVEKMLAsegiKRTDLGRDEFTKrvwewkekyggtitnQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHE 216
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 144 KGLAYRKKQAVNWCPDCKTVLADEQVVSGEcerceskvikkelEQWFFRITNYaerllkdlekidwsekvkiaqrnwigR 223
Cdd:PLN02943  217 KGLIYQGSYMVNWSPNLQTAVSDLEVEYSE-------------EPGTLYYIKY--------------------------R 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 224 SEGVEIEFkiqnsnlkIKVFTTRPDTLFGATYMVLSPEHEligklesrikNYQevkKYIqkartpaedkektgvelkGIK 303
Cdd:PLN02943  258 VAGGSEDF--------LTIATTRPETLFGDVAIAVNPEDD----------RYS---KYI------------------GKM 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 304 AVNPAN-KEEIPIWVADYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPIKPVIRRaDIPIRSVlMGFDNIHSEELVSLGI 382
Cdd:PLN02943  299 AIVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNK-DGTLNEV-AGLYWFEAREKLWSDL 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 383 KEVWPADKNHKY-IEIPENSL--PAFEKLIREKmtpgfWneYITHQRVififKDKNGL-VERLELTPGTDnkinRLSAIY 458
Cdd:PLN02943  377 EETGLAVKKEPHtLRVPRSQRggEVIEPLVSKQ-----W--FVTMEPL----AEKALKaVENGELTIIPE----RFEKIY 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 459 NnepepkgsvwNWLPDVpfykelfihtergilinsakfsgmdseeakweitkfvggerkvqyrlRDWLISRQRYWGPPIP 538
Cdd:PLN02943  442 N----------HWLSNI-----------------------------------------------KDWCISRQLWWGHRIP 464
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 539 MIFCEKCNWqpvpEQDLPVKlpylkdwrpKGTGVSPLASESKFYKvkcpkcNGEARRETDVSDTFLDSAWYFFRYLDVKN 618
Cdd:PLN02943  465 VWYIVGKDC----EEDYIVA---------RSAEEALEKAREKYGK------DVEIYQDPDVLDTWFSSALWPFSTLGWPD 525
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 619 kkeiFSKALARKWLPVDMYIGGaeHAVLHLLYVRFITKVFADLGLVgfrePSKKFRAHGlLIKD--GAKMSKSRGNVVSP 696
Cdd:PLN02943  526 ----VSAEDFKKFYPTTVLETG--HDILFFWVARMVMMGIEFTGTV----PFSYVYLHG-LIRDsqGRKMSKTLGNVIDP 594
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 697 DTYIKKFGADALRMYLMfLGPFDQGGDF---RDSGILGITRFLARVQKFE-KKLASTSKEGLAEN--------------- 757
Cdd:PLN02943  595 LDTIKEFGTDALRFTLA-LGTAGQDLNLsteRLTSNKAFTNKLWNAGKFVlQNLPSQSDTSAWEHilackfdkeesllsl 673
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 758 --SERIV----HQSIKKITEDIESLRYNTAVSQL-----------MILSNK-----------LEELPKVPWAAWEVFLKL 809
Cdd:PLN02943  674 plPECWVvsklHELIDSVTTSYDKYFFGDVGREIydffwsdfadwYIEASKtrlyhsgdnsaLSRAQAVLLYVFENILKL 753
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 810 LAPFAPYISEELYQKFgknkSFRKQnSVHLQSWPK----YNAKKIKEdvfllVVQVNGKVRATIQAPVGISEKDAERIA- 884
Cdd:PLN02943  754 LHPFMPFVTEELWQAL----PYRKE-ALIVSPWPQtslpKDLKSIKR-----FENLQSLTRAIRNARAEYSVEPAKRISa 823
                         970
                  ....*....|..
gi 1083487655 885 --LANENVKKYL 894
Cdd:PLN02943  824 siVASAEVIEYI 835
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
5-351 1.64e-21

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 100.85  E-value: 1.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   5 SRIEKKWNALWRKTGVFEP----ELGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDG 79
Cdd:PTZ00419   31 KEVESGWYEWWEKSGFFKPaedaKSLNSGKKF--VIVLPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDH 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  80 FGIHS----ENYALK---VKRHPAKQAKISEK----------NFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMF 142
Cdd:PTZ00419  109 AGIATqvvvEKKLMKeenKTRHDLGREEFLKKvwewkdkhgnNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVRLY 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 143 KKGLAYRKKQAVNWCPDCKTVLADEQVvsgecerceskvikkeleqwffritnyaerllkDLEKIDWSEKVKIAqrnwiG 222
Cdd:PTZ00419  189 EDGLIYRDTRLVNWCCYLKTAISDIEV---------------------------------EFEEIEKPTKITIP-----G 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 223 RSEGVE------IEFKIQNSNL-KIKVFTTRPDTLFGATYMVLSPEHEligklesRIKNYQevkkyiqkartpaedkekt 295
Cdd:PTZ00419  231 YDKKVEvgvlwhFAYPLEDSGQeEIVVATTRIETMLGDVAVAVHPKDE-------RYKKLH------------------- 284
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1083487655 296 gvelkGIKAVNP-ANKEEIPIwVAD--YVLGGVGTGAIMAVPAHDERDFEFAKKFKLPI 351
Cdd:PTZ00419  285 -----GKELIHPfIPDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPF 337
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
665-826 1.13e-20

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 96.72  E-value: 1.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF--RD---------SGILG-- 731
Cdd:COG0143   308 GLPLPKKVF-AHGFLTVEGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFswEDfvarvnsdlANDLGnl 386
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 732 ITRFLARVQK-FEKKLASTSKEGLAENS-ERIVHQSIKKITEDIESLRYNTAVSQLMILS---NK-LEElpKVPWA---- 801
Cdd:COG0143   387 ASRTLSMIHKyFDGKVPEPGELTEADEElLAEAEAALEEVAEAMEAFEFRKALEEIMALAraaNKyIDE--TAPWKlakd 464
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1083487655 802 ------------AWEVFLK---LLAPFAPYISEELYQKFG 826
Cdd:COG0143   465 edperlatvlytLLEALRIlaiLLKPFLPETAEKILEQLG 504
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
522-725 2.29e-18

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 87.09  E-value: 2.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 522 LRDWLISRQRYWGPPIPmifcekcnwqpvpeqdlpvklpylkdwrpkgtgvsplaseskfykvkcpkcngearreTDVSD 601
Cdd:cd00668   178 LLDWAISRQRYWGTPLP----------------------------------------------------------EDVFD 199
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 602 TFLDSAWYFFRYLDVKNKKEIFskalaRKWLPVDMYIGGAEHAVLHLLYvrFITKVFAdlglVGFREPSKKFRAHGL-LI 680
Cdd:cd00668   200 VWFDSGIGPLGSLGYPEEKEWF-----KDSYPADWHLIGKDILRGWANF--WITMLVA----LFGEIPPKNLLVHGFvLD 268
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1083487655 681 KDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQggDFR 725
Cdd:cd00668   269 EGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGD--DIR 311
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
38-228 2.45e-18

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 88.12  E-value: 2.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  38 FPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPA--------------KQAKISE 103
Cdd:pfam09334   7 LPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEelvdryheihredfKKFNISF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 104 KNFYRqlgmigngfawkekleTYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQvVSGEC--------- 174
Cdd:pfam09334  86 DDYGR----------------TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRY-VEGTCphcgsedar 148
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083487655 175 -ERCE--------------------SKVIKKELEQWFFRITNYAERLLKDLEK--IDWSEKVKIAQRNWIgrSEGVE 228
Cdd:pfam09334 149 gDQCEncgrhleptelinpkcvicgTTPEVKETEHYFFDLSKFQDKLREWIEEnnPEWPENVKNMVLEWL--KEGLK 223
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
39-214 1.47e-17

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 87.09  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  39 PYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVF---------EPIGL--DGFGIHSENYALKV-KRHPA--KQAKISEK 104
Cdd:COG0143    10 PYANGP-PHIGHLYTYIPADILARYQRLRGHDVLfvtgtdehgTKIELaaEKEGITPQELVDRIhAEFKElfEKLGISFD 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 105 NFYRqlgmigngfawkekleTYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLAD------------EQVVSG 172
Cdd:COG0143    89 NFIR----------------TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPECERFLPDryvegtcpkcgaEDAYGD 152
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 173 ECERCE-----------------SKVIKKELEQWFFRITNYAERLLKDLEKI-DWSEKVK 214
Cdd:COG0143   153 QCENCGatleptelinprsaisgAPPELREEEHYFFRLSKYQDRLLEWIEENpDIQPEVR 212
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
39-206 2.27e-17

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 86.47  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  39 PYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGihsenyaLKVKRHpAKQAKISEKNFYRQlgmigNGFA 118
Cdd:PRK11893   10 YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHG-------QKIQRK-AEEAGISPQELADR-----NSAA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 119 WKEKLE-----------TYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVSGE--CERCESKVIKKE 185
Cdd:PRK11893   76 FKRLWEalnisyddfirTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDGyrCPPTGAPVEWVE 155
                         170       180
                  ....*....|....*....|.
gi 1083487655 186 LEQWFFRITNYAERLLKDLEK 206
Cdd:PRK11893  156 EESYFFRLSKYQDKLLELYEA 176
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
521-713 2.61e-17

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 84.21  E-value: 2.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 521 RLRDWLISRQRYWGPPIPMIFCEKCNwqpvpeqdlpvklpylkdwrpkgtgvsplaseskfyKVKCpkcngeaRRETDVS 600
Cdd:cd00818   188 NRRDWCISRQRYWGTPIPVWYCEDCG------------------------------------EVLV-------RRVPDVL 224
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 601 DTFLDS--AWYFfrYLDVKNKKEIFSkalaRKWlPVDMYIGGAEHA-----VLHLLYVrfitkvfadlGLVGfREPSKKF 673
Cdd:cd00818   225 DVWFDSgsMPYA--QLHYPFENEDFE----ELF-PADFILEGSDQTrgwfySLLLLST----------ALFG-KAPYKNV 286
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1083487655 674 RAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLM 713
Cdd:cd00818   287 IVHGFvLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVA 327
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
763-878 4.39e-17

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 78.60  E-value: 4.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 763 HQSIKKITEDIESLRYNTAVSQLM-----ILSNKLEELPK--------------VPWAAWEVFLKLLAPFAPYISEELYQ 823
Cdd:pfam08264   9 NKLIKEVTEAYENYRFNTAAQALYeffwnDLSDWYLELIKdrlygeepdsraqtTLYEVLETLLRLLAPFMPFITEELWQ 88
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 824 KfgknksfrkqNSVHLQSWPKYNAKKIKE-----DVFLLVVQVNGKVRATIQAPVGISEK 878
Cdd:pfam08264  89 K----------ESIHLAPWPEDAELEEAEleeafELRQEIVQAIRKLRSELKIKKSLPLE 138
PLN02381 PLN02381
valyl-tRNA synthetase
5-708 5.54e-17

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 86.11  E-value: 5.54e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655    5 SRIEKKWNALWRKTGVFEPELGRAKKPFynLMMFPYPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIH 83
Cdd:PLN02381   103 SAVEKSWYAWWEKSGYFGADAKSSKPPF--VIVLPPPNVTGaLHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIA 180
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   84 SENYALK-------VKRHPAKQAK-ISE----KNFY-----RQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGL 146
Cdd:PLN02381   181 TQVVVEKklmrerhLTRHDIGREEfVSEvwkwKDEYggtilNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGL 260
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  147 AYRKKQAVNWcpDC--KTVLADEQVvsgecERCESKvikkelEQWFFRITNYAERLlkdlekidwsekvkiaqrnwigrS 224
Cdd:PLN02381   261 IYRDIRLVNW--DCtlRTAISDVEV-----DYIDIK------ERTLLKVPGYDKPV-----------------------E 304
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  225 EGVEIEFK--IQNSNLKIKVFTTRPDTLFGATYMVLSPEHEligklesRIKNyqevkkyiqkartpaedkektgveLKGI 302
Cdd:PLN02381   305 FGVLTSFAypLEGGLGEIVVATTRIETMLGDTAIAIHPDDE-------RYKH------------------------LHGK 353
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  303 KAVNPANKEEIPIwVADYVL--GGVGTGAIMAVPAHDERDFEFAKKFKLPikpvirradipirsvlmgFDNIHSEELvsl 380
Cdd:PLN02381   354 FAVHPFNGRKLPI-ICDAILvdPNFGTGAVKITPAHDPNDFEVGKRHNLE------------------FINIFTDDG--- 411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  381 gikevwpadknhkyiEIPENSLPAFEKLIRekmtpgfwneyithqrvifiFKDKNGLVERLE---LTPGTDNKINRL--S 455
Cdd:PLN02381   412 ---------------KINSNGGSEFAGMPR--------------------FAAREAVIEALQkkgLYRGAKNNEMRLglC 456
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  456 AIYNNEPEPKgsvwnwlpdvpFYKELFIHTErgILINSAKFSGMDSEEAKWEI--TKFVGGERKVQYRLRDWLISRQRYW 533
Cdd:PLN02381   457 SRTNDVVEPM-----------IKPQWFVNCS--SMAKQALDAAIDGENKKLEFipKQYLAEWKRWLENIRDWCISRQLWW 523
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  534 GPPIPMifcekcnWQPVPEQDLPVKLPYLKD-WRPKGTGVSPLASESKfykvKCPKCNGEARRETDVSDTFLDSAWYFFR 612
Cdd:PLN02381   524 GHRIPA-------WYVTLEDDQLKELGSYNDhWVVARNESDALLEASQ----KFPGKKFELSQDPDVLDTWFSSGLFPLS 592
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  613 YLDVKNKKEIFskalaRKWLPVDMYIGGaeHAVLHLLYVRFITkvfadLGL-VGFREPSKKFRAHGlLIKD--GAKMSKS 689
Cdd:PLN02381   593 VLGWPDDTDDL-----KAFYPTSVLETG--HDILFFWVARMVM-----MGMqLGGDVPFRKVYLHP-MIRDahGRKMSKS 659
                          730
                   ....*....|....*....
gi 1083487655  690 RGNVVSPDTYIKKFGADAL 708
Cdd:PLN02381   660 LGNVIDPLEVINGISLEGL 678
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
31-221 8.90e-17

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 82.08  E-value: 8.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  31 PFYNLMMFPYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYA-------------LKVKRHPAK 97
Cdd:cd00668     1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  98 QAKISEKNFYRQLGMIGNGFAWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVnwcpdcktvladeqvvsgecerc 177
Cdd:cd00668    80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV----------------------- 136
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1083487655 178 eskvikKELEQWFFRITNYAERLLKDLEKIDW-SEKVKIAQRNWI 221
Cdd:cd00668   137 ------RITEQWFFDMPKFKEKLLKALRRGKIvPEHVKNRMEAWL 175
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
39-221 1.91e-16

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 81.42  E-value: 1.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  39 PYPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQA-KISE--KNFYRQLGMIGN 115
Cdd:cd00814     9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCdKYHEifKDLFKWLNISFD 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 116 GFAwkeklETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLAdeqvvsgecerceskVIKKElEQWFFRITN 195
Cdd:cd00814    88 YFI-----RTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP---------------EWREE-EHYFFRLSK 146
                         170       180
                  ....*....|....*....|....*....
gi 1083487655 196 YAERLLKDLEK---IDWSEKVKIAQRNWI 221
Cdd:cd00814   147 FQDRLLEWLEKnpdFIWPENARNEVLSWL 175
PLN02843 PLN02843
isoleucyl-tRNA synthetase
8-848 8.63e-16

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 82.13  E-value: 8.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655   8 EKKWNALWRKTGVFEPELGRAKKPFYNLMMFPyPSAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSEn 86
Cdd:PLN02843    9 EPEIQKLWEENQVYKRVSDRNNGESFTLHDGP-PYANGdLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIE- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  87 yaLKV-------KRHPAKQAKISEK--NF-----------YRQLGMIGNgfaWKEKLETYDPEYYKWTQWIFVQMFKKGL 146
Cdd:PLN02843   87 --LKVlqsldqeARKELTPIKLRAKaaKFakktvdtqresFKRYGVWGD---WENPYLTLDPEYEAAQIEVFGQMFLNGY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 147 AYRKKQAVNWCPDCKTVLADeqvvsGECERCESKVIKKELEQwfFRITNYAERLlkdlekidwsekvkiaqrnwigrseG 226
Cdd:PLN02843  162 IYRGRKPVHWSPSSRTALAE-----AELEYPEGHVSKSIYVA--FPVVSPSETS-------------------------P 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 227 VEIEFKIQNSNLKIkvFTTRPDTLFG---------ATYMVL---SPEHELIGKLESRIKNYQEVKKYIQKAR-TPAED-- 291
Cdd:PLN02843  210 EELEEFLPGLSLAI--WTTTPWTMPAnaavavndkLQYSVVevqSFSEDESTSGGNKKKRPGNVLKEQQKLFlIVATDlv 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 292 ---KEKTGVELKGIKAV-----------NPANKEEIPIWVA-DYVLGGVGTGAIMAVPAHDERDFEFAKKFKLPI-KPV- 354
Cdd:PLN02843  288 palEAKWGVKLVVLKTFpgsdlegcryiHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLlSPVd 367
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 355 ------IRRADIPIRSVLmGFDNI----HSEELVSLGIKEVWpadkNHKYieipenslpafeklirekmtPGFWNeyiTH 424
Cdd:PLN02843  368 dagkftEEAGQFSGLSVL-GEGNAavveALDEAGSLLMEEAY----GHKY--------------------PYDWR---TK 419
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 425 QRVIF-----IFKDKNGLVErleltpgtdnkiNRLSAIYNNEpepkgsvwnWLPdvpfykelfihtergilinsakfsgm 499
Cdd:PLN02843  420 KPTIFrateqWFASVEGFRQ------------AALDAIDKVK---------WIP-------------------------- 452
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 500 dsEEAKWEITKFVGGeRKvqyrlrDWLISRQRYWGPPIPmIFCEKCNWQPVPEQDlpvKLPYLKD-WRPKGT------GV 572
Cdd:PLN02843  453 --AQGENRIRAMVSG-RS------DWCISRQRTWGVPIP-VFYHVETKEPLMNEE---TIAHVKSiVAQKGSdawwymDV 519
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 573 SPLASESkfYKVKCPKcngeARRETDVSDTFLDSAwyfFRYLDVKNKKEIFSkalarkwLPVDMYIGGAEHavlH----- 647
Cdd:PLN02843  520 EDLLPEK--YRDKASD----YEKGTDTMDVWFDSG---SSWAGVLGSREGLS-------YPADLYLEGSDQ---Hrgwfq 580
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 648 --LLyvrfiTKVfADLGlvgfREPSKKFRAHG-LLIKDGAKMSKSRGNVVSPDTYI-----KK----FGADALRMYlmfL 715
Cdd:PLN02843  581 ssLL-----TSV-ATKG----KAPYKSVLTHGfVLDEKGFKMSKSLGNVVDPRLVIeggknQKqepaYGADVLRLW---V 647
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 716 GPFDQGGDFR-DSGIL-----------GITRFL-ARVQKFEKKLASTSKE--GLAENSERIVHQSIKKITEDIESLRYNT 780
Cdd:PLN02843  648 ASVDYTGDVLiGPQILkqmsdiyrklrGTLRYLlGNLHDWKPDNAVPYEDlpSIDKYALFQLENVVNEIEESYDNYQFFK 727
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 781 AVSQL-----MILSNKLEELPK------------------VPWAAWEVFLKLLAPFAPYISEELYQKFGKNKSFRKQNSV 837
Cdd:PLN02843  728 IFQILqrftiVDLSNFYLDVAKdrlyvggttsftrrscqtVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAESV 807
                         970
                  ....*....|.
gi 1083487655 838 HLQSWPKYNAK 848
Cdd:PLN02843  808 FEAGWPTPNEE 818
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
661-826 1.07e-15

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 81.39  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 661 LGLvgfrEPSKKFRAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGI----------- 729
Cdd:PRK12267  279 LGL----PLPKKVFAHGWWLMKDGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSPEALverinsdland 354
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 730 LG--ITRFLARVQK-FEKKL-ASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMIL---SNKL---------- 792
Cdd:PRK12267  355 LGnlLNRTVAMINKyFDGEIpAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLisrANKYidetapwvla 434
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1083487655 793 ------EELPKVPWAAWEVFLK---LLAPFAPYISEELYQKFG 826
Cdd:PRK12267  435 kdegkkERLATVMYHLAESLRKvavLLSPFMPETSKKIFEQLG 477
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
671-826 2.09e-15

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 79.93  E-value: 2.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 671 KKFRAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGI-----------LG--ITRFLA 737
Cdd:PRK11893  285 KRVFAHGFLTLDGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFinrinadlandLGnlAQRTLS 364
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 738 RVQK-FEKKLASTSKEGLAENSERI-VHQSIKKITEDIESLRYNTAVSQLMILSNKL-----EELPKVPWAAWEVFLK-- 808
Cdd:PRK11893  365 MIAKnFDGKVPEPGALTEADEALLEaAAALLERVRAAMDNLAFDKALEAILALVRAAnkyidEQAPWSLAKTDPERLAtv 444
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1083487655 809 -------------LLAPFAPYISEELYQKFG 826
Cdd:PRK11893  445 lytllevlrgiavLLQPVMPELAAKILDQLG 475
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
665-724 5.50e-14

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 74.11  E-value: 5.50e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF 724
Cdd:cd00814   261 GLPLPTRIV-AHGYLTVEGKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
41-221 1.17e-13

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 73.42  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  41 PSAEGL-HVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFG---------------------IHSENYALKVKRHPAKQ 98
Cdd:cd00818    10 PYANGLpHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGlpielkvekelgisgkkdiekMGIAEFNAKCREFALRY 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  99 AKISEKNFYRqLGMIGNgfaWKEKLETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWcPdcktvladeqvvsgecerce 178
Cdd:cd00818    90 VDEQEEQFQR-LGVWVD---WENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-P-------------------- 144
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1083487655 179 skVIKKELEQWFFRITNYAERLLKDLEKIDW-SEKVKIAQRNWI 221
Cdd:cd00818   145 --LIYRATPQWFIRVTKIKDRLLEANDKVNWiPEWVKNRFGNWL 186
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
665-739 1.66e-13

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 73.48  E-value: 1.66e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGilgitrFLARV 739
Cdd:pfam09334 305 GYRLPTTVF-AHGYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWED------FVERV 372
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
763-854 3.85e-11

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 62.95  E-value: 3.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 763 HQSIKKITEDIESLRYNTAVSQLM----ILSN----------KLEELPKVPWAAWEV-------FLKLLAPFAPYISEEL 821
Cdd:cd07961    57 NSLIKEVTEEMEAYDLYTAVRALLefidELTNwyirrnrkrfWGEEGDDDKLAAYATlyevlltLSRLMAPFTPFITEEI 136
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1083487655 822 YQKFGKNKSFRKQnSVHLQSWPKYNAKKIKEDV 854
Cdd:cd07961   137 YQNLRRELGDAPE-SVHLLDWPEVDESLIDEEL 168
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
29-202 5.32e-11

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 66.36  E-value: 5.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  29 KKPFYnlMMFP--YPSAEgLHVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGihsenyaLKVKRhPAKQAKISEKNF 106
Cdd:PRK12267    3 KKTFY--ITTPiyYPNGK-PHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG-------QKIQQ-AAEKAGKTPQEY 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 107 -------YRQLgmigngfaWKeKLE--------TYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVS 171
Cdd:PRK12267   72 vdeisagFKEL--------WK-KLDisydkfirTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVD 142
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1083487655 172 GE-CERCESKVIKKELEQWFFRITNYAERLLK 202
Cdd:PRK12267  143 GGkCPDCGREVELVKEESYFFRMSKYQDRLLE 174
PLN02882 PLN02882
aminoacyl-tRNA ligase
523-854 9.45e-11

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 65.90  E-value: 9.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  523 RDWLISRQRYWGPPIPMifcekcnWQPVPEQDLPV-----KLPYLKdwrpkGTGVSPLASEsKFYKVKCPKCNG----EA 593
Cdd:PLN02882   465 RDWAVSRSRFWGTPLPI-------WISDDGEEVVVigsiaELEKLS-----GVKVTDLHRH-FIDHITIPSSRGpefgVL 531
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  594 RRETDVSDTFLDSAW--YFFRYLDVKNKkEIFSKALarkwlPVDMYIGGaehavlhLLYVR--FITKVFADLGLvgFREP 669
Cdd:PLN02882   532 RRVDDVFDCWFESGSmpYAYIHYPFENK-ELFEKNF-----PADFVAEG-------LDQTRgwFYTLMVLSTAL--FDKP 596
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  670 S-KKFRAHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFlGPFDQGGD--FRDSGILGIT-----------R 734
Cdd:PLN02882   597 AfKNLICNGLvLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN-SPVVRAEPlrFKEEGVFGVVkdvflpwynayR 675
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  735 FLarVQKFEK-------KLASTSKEGLAENS---ERIVHQS----IKKITEDIESLRYNTAVSQLMILSNKL-------- 792
Cdd:PLN02882   676 FL--VQNAKRleveggaPFVPLDLAKLQNSAnvlDRWINSAtqslVKFVREEMGAYRLYTVVPYLVKFIDNLtniyvrfn 753
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1083487655  793 ---------EELPKVPWAA-WEVFL---KLLAPFAPYISEELYQKFGKNKSfRKQNSVHLQSWPKYNAKKIKEDV 854
Cdd:PLN02882   754 rkrlkgrtgEEDCRTALSTlYNVLLtscKVMAPFTPFFTEVLYQNLRKVLP-GSEESIHYCSFPQVDEGELDERI 827
metG PRK00133
methionyl-tRNA synthetase; Reviewed
665-826 4.86e-10

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 63.25  E-value: 4.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 665 GFREPSKKFrAHGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGP---------FDqggDFRDS------GI 729
Cdd:PRK00133  310 GYRLPTNVF-AHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLAAKLPetiddldfnWE---DFQQRvnselvGK 385
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 730 LG--ITR---FLARvqKFEKKLASTSKEglAENSERIVhQSIKKITEDIESLRYNTAVSQLMILS---NK-LEElpKVPW 800
Cdd:PRK00133  386 VVnfASRtagFINK--RFDGKLPDALAD--PELLEEFE-AAAEKIAEAYEAREFRKALREIMALAdfaNKyVDD--NEPW 458
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1083487655 801 AAWE------------------VFLKLLAPFAPYISEELYQKFG 826
Cdd:PRK00133  459 KLAKqdgerlqavcsvglnlfrALAIYLKPVLPELAERAEAFLN 502
metG PRK00133
methionyl-tRNA synthetase; Reviewed
39-180 5.97e-10

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 62.86  E-value: 5.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  39 PYpsAEG-LHVGNMYAFVGSDIYGRFQRMRGNDVF---------EPIGL--DGFGIHSENYALKV-KRHPA--KQAKISE 103
Cdd:PRK00133   11 PY--ANGpIHLGHLVEYIQADIWVRYQRMRGHEVLfvcaddahgTPIMLkaEKEGITPEELIARYhAEHKRdfAGFGISF 88
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083487655 104 KNFYRqlgmigngfawkekleTYDPEYYKWTQWIFVQMFKKGLAYRK--KQAvnWCPDCKTVLADEQVVsGECERCESK 180
Cdd:PRK00133   89 DNYGS----------------THSEENRELAQEIYLKLKENGYIYEKtiEQL--YDPEKGMFLPDRFVK-GTCPKCGAE 148
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
523-864 4.49e-08

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 57.28  E-value: 4.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  523 RDWLISRQRYWGPPIPMIFCEKCNWQPVPEQdlpvkLPYLKdwrpKGTGVSPLASESKFY----KVKCPKCNG--EARRE 596
Cdd:PTZ00427   569 KDWCISRNRYWGTPIPIWADEKMETVICVES-----IKHLE----ELSGVKNINDLHRHFidhiEIKNPKGKTypKLKRI 639
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  597 TDVSDTFLDSAW--YFFRYLDVKNKKEIFSKALarkwlPVDMYIGGAEHAVLHLLYVRFITKVFADlglvgfREPSKKFR 674
Cdd:PTZ00427   640 PEVFDCWFESGSmpYAKVHYPFSTEKEDFHKIF-----PADFIAEGLDQTRGWFYTLLVISTLLFD------KAPFKNLI 708
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  675 AHGL-LIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLM-FLGPFDQGGDFRDSGILGITR------------FLARVQ 740
Cdd:PTZ00427   709 CNGLvLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLInSVAVRAENLKFQEKGVNEVVKsfilpfyhsfrfFSQEVT 788
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  741 KFE---KKLASTSKEGLAENSE--------------RIVHQSIK---------KITEDIESL-----RYNTAVSQLMILS 789
Cdd:PTZ00427   789 RYEclnKKQFLFNTDYIYKNDNimdqwifssvqsltKSVHTEMKayklynvlpKLLQFIENLtnwyiRLNRDRMRGSLGE 868
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083487655  790 NKLEELPKVPWAAWEVFLKLLAPFAPYISEELYQKFGKNKSFRKQNSVHLQ---SWPKYNAKKIKEDV-FLLVVQVNGK 864
Cdd:PTZ00427   869 ENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKSTNEHNENNETgntKEGDLNRGVIHKSVhFIMLPQVDEK 947
PLN02224 PLN02224
methionine-tRNA ligase
603-826 4.52e-08

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 57.03  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 603 FLDSAWYFFRYLDVKNKKEIFSKALARKWlPVDMYIGGAEHAVLHLLYVRfitkvfADLGLVGFREPSKKFrAHGLLIKD 682
Cdd:PLN02224  292 WFDALLGYISALTEDNKQQNLETAVSFGW-PASLHLIGKDILRFHAVYWP------AMLMSAGLELPKMVF-GHGFLTKD 363
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 683 GAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDFRDSGILGIT---------RFLARVQKFEKKL------- 746
Cdd:PLN02224  364 GMKMGKSLGNTLEPFELVQKFGPDAVRYFFLREVEFGNDGDYSEDRFIKIVnahlantigNLLNRTLGLLKKNcestlve 443
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 747 -ASTSKEG--LAENSERIVhqsiKKITEDIESLRYNTAVSQLMILSNKLEEL--PKVPW------------AAWEVFLKL 809
Cdd:PLN02224  444 dSTVAAEGvpLKDTVEKLV----EKAQTNYENLSLSSACEAVLEIGNAGNTYmdQRAPWflfkqggvsaeeAAKDLVIIL 519
                         250       260
                  ....*....|....*....|....*.
gi 1083487655 810 ---------LAPFAPYISEELYQKFG 826
Cdd:PLN02224  520 evmrviavaLSPIAPCLSLRIYSQLG 545
PLN02224 PLN02224
methionine-tRNA ligase
47-204 4.00e-06

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 50.48  E-value: 4.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  47 HVGNMYAFVGSDIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPAKQAKI---SEKNFYRQLGMigngfAWKEKL 123
Cdd:PLN02224   85 HMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIisqSYRTLWKDLDI-----AYDKFI 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 124 ETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADEQVVSGECerC---ESKVIKKELEQWFFRITNYaERL 200
Cdd:PLN02224  160 RTTDPKHEAIVKEFYARVFANGDIYRADYEGLYCVNCEEYKDEKELLENNC--CpvhQMPCVARKEDNYFFALSKY-QKP 236

                  ....
gi 1083487655 201 LKDL 204
Cdd:PLN02224  237 LEDI 240
Anticodon_Ia_Val cd07962
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ...
763-825 7.15e-06

Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.


Pssm-ID: 153416 [Multi-domain]  Cd Length: 135  Bit Score: 46.40  E-value: 7.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 763 HQSIKKITEDIESLRYNTAVSQL--------------MI---LSNKLEELPKVPWA----AWEVFLKLLAPFAPYISEEL 821
Cdd:cd07962    52 NKTVEEVTEALENYRFSEAATALyeffwndfcdwyleLVkprLYGEDEEEKKAARAtlyyVLETILRLLHPFMPFITEEL 131

                  ....
gi 1083487655 822 YQKF 825
Cdd:cd07962   132 WQRL 135
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
724-825 1.76e-05

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 44.89  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 724 FRDSGILGITRFLARVQKFEKKLASTSKEGLAEN-------SEriVHQSIKKITEDIESLRYNTAV-SQLMILSNKLEE- 794
Cdd:cd07959     1 FREEEANSAILRLERFYELAEELIETEGELEELTfidrwllSR--LNRLIKETTEAYENMQFREALkEGLYELQNDLDWy 78
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1083487655 795 ---LPKVP-----WAAWEVFLKLLAPFAPYISEELYQKF 825
Cdd:cd07959    79 rerGGAGMnkdllRRFIEVWTRLLAPFAPHLAEEIWHEL 117
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
676-713 3.39e-04

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 44.32  E-value: 3.39e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1083487655 676 HGLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLM 713
Cdd:COG0215   256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLL 293
Anticodon_Ia_Ile_BEm cd07960
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ...
804-854 1.29e-03

Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153414 [Multi-domain]  Cd Length: 180  Bit Score: 40.59  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1083487655 804 EVFLKLLAPFAPYISEELYQKFGKNKsfrKQNSVHLQSWPKYNAKKIKEDV 854
Cdd:cd07960   118 DALLKLLAPILPFTAEEVWEHLPGEK---KEESVFLEDWPELPEEWKDEEL 165
Anticodon_Ia_like cd07375
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ...
735-814 1.85e-03

Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.


Pssm-ID: 153408 [Multi-domain]  Cd Length: 117  Bit Score: 39.03  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655 735 FLARVQKFEKKLASTSKEGLAENSERIVHQSIKKITEDIESLRYNTAVSQLMILSNKLEELPKVPW-------------- 800
Cdd:cd07375    21 FRKALGGTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNELNWYLDELKpalqteelreavla 100
                          90
                  ....*....|....*..
gi 1083487655 801 ---AAWEVFLKLLAPFA 814
Cdd:cd07375   101 vlrAALVVLTKLLAPFT 117
PLN02959 PLN02959
aminoacyl-tRNA ligase
605-847 4.34e-03

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 40.82  E-value: 4.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  605 DSAW-YFFRYLDVKNKKEIFSKALARK------WLPVDMYIGGAEHAVLHLLYVRFI-TKVFADlglvgfREPSKKFRAH 676
Cdd:PLN02959   636 DEVWdFVFCGGPLPKSSDIPAELLEKMkqefeyWYPFDLRVSGKDLIQNHLTFAIYNhTAIWAE------EHWPRGFRCN 709
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  677 GLLIKDGAKMSKSRGNVVSPDTYIKKFGADALRMYLMFLGPFDQGGDF----RDSGILGITRFLA---RVQKFEKKLAST 749
Cdd:PLN02959   710 GHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFvfetANAAILRLTKEIAwmeEVLAAESSLRTG 789
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  750 SKEGLA----ENSERIVHQSIKKITEDI---ESLRynTAVSQLMI------LSNKLEELPK-VPWAAWEVFLKLLAPFAP 815
Cdd:PLN02959   790 PPSTYAdrvfENEINIAIAETEKNYEAMmfrEALK--SGFYDLQAardeyrLSCGSGGMNRdLVWRFMDVQTRLITPICP 867
                          250       260       270
                   ....*....|....*....|....*....|..
gi 1083487655  816 YISEELYQKFgknksFRKQNSVHLQSWPKYNA 847
Cdd:PLN02959   868 HYAEHVWREI-----LKKEGFAVTAGWPVAGE 894
PLN02610 PLN02610
probable methionyl-tRNA synthetase
47-177 5.42e-03

probable methionyl-tRNA synthetase


Pssm-ID: 215329 [Multi-domain]  Cd Length: 801  Bit Score: 40.53  E-value: 5.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083487655  47 HVGNMYAFVGS-DIYGRFQRMRGNDVFEPIGLDGFGIHSENYALKVKRHPA----KQAKIsEKNFYRQLGMIGNGFAwke 121
Cdd:PLN02610   33 HLGNIIGCVLSaDVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKeicdKYHAI-HKEVYDWFDISFDKFG--- 108
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1083487655 122 klETYDPEYYKWTQWIFVQMFKKGLAYRKKQAVNWCPDCKTVLADeQVVSGECERC 177
Cdd:PLN02610  109 --RTSTPQQTEICQAIFKKLMENNWLSENTMQQLYCDTCQKFLAD-RLVEGTCPTE 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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