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Conserved domains on  [gi|1083527486|gb|OGG27478|]
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hypothetical protein A2960_04235 [Candidatus Gottesmanbacteria bacterium RIFCSPLOWO2_01_FULL_39_12b]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 2-375 7.49e-84

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03802:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 333  Bit Score: 258.37  E-value: 7.49e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486   2 KIGIFISPRHRVPPdedKILAPWYL-IKDLADGLVLRKNEVCLFAAHSSQTKATLydfgIEAYPHDKnpltqsdWEKIKS 80
Cdd:cd03802     1 RIAQVSPPRGPVPP---GKYGGTELvVSALTEGLVRRGHEVTLFAPGDSHTSAPL----VAVIPRAL-------RLDPIP 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  81 SDQLLFSKMMAKGKELSL---DIYHLNqveFIDEI-IYSSPPENRYVFTLHDPITPEREKIIKAleqRKNCYFVSISNSQ 156
Cdd:cd03802    67 QESKLAELLEALEVQLRAsdfDVIHNH---SYDWLpPFAPLIGTPFVTTLHGPSIPPSLAIYAA---EPPVNYVSISDAQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 157 RNNLPF-RFIDTVYNGTDLSHYPFQDVPSDYLLFMGRIRKEKGLHHAIAVSLRLNIPLEIGAPVlniqDSDEYFYKQIRP 235
Cdd:cd03802   141 RAATPPiDYLTVVHNGLDPADYRFQPDPEDYLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKV----RDEDYFYYLQEP 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 236 YLdNPLIGEPGFLEGKNKILLYRQARLLLFPIEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEdk 315
Cdd:cd03802   217 LP-GPRIEFIGEVGHDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEE-- 293

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 316 rgdwiikktgiegLVEAVNKIysmgeKEYRemRFACRRHVEEKFSVEKMVEGYEQVYQRI 375
Cdd:cd03802   294 -------------MAEAIANI-----DRID--RAACRRYAEDRFSAARMADRYEALYRKV 333
 
Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 2-375 7.49e-84

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 258.37  E-value: 7.49e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486   2 KIGIFISPRHRVPPdedKILAPWYL-IKDLADGLVLRKNEVCLFAAHSSQTKATLydfgIEAYPHDKnpltqsdWEKIKS 80
Cdd:cd03802     1 RIAQVSPPRGPVPP---GKYGGTELvVSALTEGLVRRGHEVTLFAPGDSHTSAPL----VAVIPRAL-------RLDPIP 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  81 SDQLLFSKMMAKGKELSL---DIYHLNqveFIDEI-IYSSPPENRYVFTLHDPITPEREKIIKAleqRKNCYFVSISNSQ 156
Cdd:cd03802    67 QESKLAELLEALEVQLRAsdfDVIHNH---SYDWLpPFAPLIGTPFVTTLHGPSIPPSLAIYAA---EPPVNYVSISDAQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 157 RNNLPF-RFIDTVYNGTDLSHYPFQDVPSDYLLFMGRIRKEKGLHHAIAVSLRLNIPLEIGAPVlniqDSDEYFYKQIRP 235
Cdd:cd03802   141 RAATPPiDYLTVVHNGLDPADYRFQPDPEDYLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKV----RDEDYFYYLQEP 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 236 YLdNPLIGEPGFLEGKNKILLYRQARLLLFPIEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEdk 315
Cdd:cd03802   217 LP-GPRIEFIGEVGHDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEE-- 293

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 316 rgdwiikktgiegLVEAVNKIysmgeKEYRemRFACRRHVEEKFSVEKMVEGYEQVYQRI 375
Cdd:cd03802   294 -------------MAEAIANI-----DRID--RAACRRYAEDRFSAARMADRYEALYRKV 333
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 256-377 2.79e-29

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 109.69  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 256 LYRQARLLLFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSseedkrGDwiikktgIEGLVEAVNK 335
Cdd:COG0438    17 LLAAADVFVLPSRSE-GFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPP------GD-------PEALAEAILR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1083527486 336 IYSMGEkEYREMRFACRRHVEEKFSVEKMVEGYEQVYQRILN 377
Cdd:COG0438    83 LLEDPE-LRRRLGEAARERAEERFSWEAIAERLLALYEELLA 123
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 186-342 5.32e-23

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 93.88  E-value: 5.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 186 YLLFMGRIRKEKGLHHAI--AVSLRLNIPlEIGAPVLNIQDSDEYFYKQIRPYLDNPLIGEPGFLEGKNKILLYRQARLL 263
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIkaFALLKEKNP-NLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083527486 264 LFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVnsseedKRGDWiikktgiEGLVEAVNKIYSMGEK 342
Cdd:pfam00534  83 VLPSRYE-GFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLV------KPNNA-------EALAEAIDKLLEDEEL 147
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 279-376 1.89e-13

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 70.91  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 279 EAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEdkrgdwiikktgiEGLVEAVNKIYSMGEKEYREMRfACRRHVEEK 358
Cdd:TIGR03088 291 EAMASGLPVIATAVGGNPELVQHGVTGALVPPGDA-------------VALARALQPYVSDPAARRAHGA-AGRARAEQQ 356

                          90
                  ....*....|....*...
gi 1083527486 359 FSVEKMVEGYEQVYQRIL 376
Cdd:TIGR03088 357 FSINAMVAAYAGLYDQLL 374
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
113-306 5.95e-11

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 63.27  E-value: 5.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 113 IYSSPPENRYVFTLHDPITPER----EKIIKALEQRKNCYfvsisnsqRNNLPFRFIDTVYNGTDLSHYPFQ-------- 180
Cdd:PRK15484  115 IRERAPQAKLVMHMHNAFEPELldknAKIIVPSQFLKKFY--------EERLPNADISIVPNGFCLETYQSNpqpnlrqq 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 181 -DVPSD--YLLFMGRIRKEKG---LHHAIA--VSLRLNIPLEIGAPVLNIQDSDEYFY-KQIRPYLDNplIGEPGFLEG- 250
Cdd:PRK15484  187 lNISPDetVLLYAGRISPDKGillLMQAFEklATAHSNLKLVVVGDPTASSKGEKAAYqKKVLEAAKR--IGDRCIMLGg 264

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1083527486 251 ---KNKILLYRQARLLLFPIEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGF 306
Cdd:PRK15484  265 qppEKMHNYYPLADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGY 323
 
Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 2-375 7.49e-84

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 258.37  E-value: 7.49e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486   2 KIGIFISPRHRVPPdedKILAPWYL-IKDLADGLVLRKNEVCLFAAHSSQTKATLydfgIEAYPHDKnpltqsdWEKIKS 80
Cdd:cd03802     1 RIAQVSPPRGPVPP---GKYGGTELvVSALTEGLVRRGHEVTLFAPGDSHTSAPL----VAVIPRAL-------RLDPIP 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  81 SDQLLFSKMMAKGKELSL---DIYHLNqveFIDEI-IYSSPPENRYVFTLHDPITPEREKIIKAleqRKNCYFVSISNSQ 156
Cdd:cd03802    67 QESKLAELLEALEVQLRAsdfDVIHNH---SYDWLpPFAPLIGTPFVTTLHGPSIPPSLAIYAA---EPPVNYVSISDAQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 157 RNNLPF-RFIDTVYNGTDLSHYPFQDVPSDYLLFMGRIRKEKGLHHAIAVSLRLNIPLEIGAPVlniqDSDEYFYKQIRP 235
Cdd:cd03802   141 RAATPPiDYLTVVHNGLDPADYRFQPDPEDYLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKV----RDEDYFYYLQEP 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 236 YLdNPLIGEPGFLEGKNKILLYRQARLLLFPIEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEdk 315
Cdd:cd03802   217 LP-GPRIEFIGEVGHDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEE-- 293

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 316 rgdwiikktgiegLVEAVNKIysmgeKEYRemRFACRRHVEEKFSVEKMVEGYEQVYQRI 375
Cdd:cd03802   294 -------------MAEAIANI-----DRID--RAACRRYAEDRFSAARMADRYEALYRKV 333
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 27-373 3.07e-38

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 140.75  E-value: 3.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  27 IKDLADGLVLRKNEVCLFAAhssQTKATLYDFGIEAYPHDKNPLTQSDWEKIKSSDQLLFSKMMAKGkelslDIYHLNQV 106
Cdd:cd03801    20 VRELARALAARGHDVTVLTP---ADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRKF-----DVVHAHGL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 107 EFI-DEIIYSSPPENRYVFTLHDPITPE-------REKIIKALEQRKNCY--FVSISNSQRNNL------PFRFIDTVYN 170
Cdd:cd03801    92 LAAlLAALLALLLGAPLVVTLHGAEPGRlllllaaERRLLARAEALLRRAdaVIAVSEALRDELralggiPPEKIVVIPN 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 171 GTDLSHYPFQDVPS-------DYLLFMGRIRKEKGLHHAIAVsLRLNIPLEIGAPVLNIQDSDEYF--YKQIRPYLDNPL 241
Cdd:cd03801   172 GVDLERFSPPLRRKlgippdrPVLLFVGRLSPRKGVDLLLEA-LAKLLRRGPDVRLVIVGGDGPLRaeLEELELGLGDRV 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 242 IGePGFLEGKNKILLYRQARLLLFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEedkrgdwii 321
Cdd:cd03801   251 RF-LGFVPDEELPALYAAADVFVLPSRYE-GFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDD--------- 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1083527486 322 kktgIEGLVEAVNKIYSMGEKeYREMRFACRRHVEEKFSVEKMVEGYEQVYQ 373
Cdd:cd03801   320 ----VEALADALLRLLADPEL-RARLGRAARERVAERFSWERVAERLLDLYR 366
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 256-377 2.79e-29

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 109.69  E-value: 2.79e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 256 LYRQARLLLFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSseedkrGDwiikktgIEGLVEAVNK 335
Cdd:COG0438    17 LLAAADVFVLPSRSE-GFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPP------GD-------PEALAEAILR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1083527486 336 IYSMGEkEYREMRFACRRHVEEKFSVEKMVEGYEQVYQRILN 377
Cdd:COG0438    83 LLEDPE-LRRRLGEAARERAEERFSWEAIAERLLALYEELLA 123
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 28-369 1.10e-26

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 108.96  E-value: 1.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  28 KDLADGLVLRKNEVCLFAAHSSQTKATLYDFGIEAYPHDKNPLTQSDWEKIKSSDQLLFSKMMAKG-----KELSLDIYH 102
Cdd:cd03823    22 HDLAEALVAEGHEVAVLTAGVGPPGQATVARSVVRYRRAPDETLPLALKRRGYELFETYNPGLRRLlarllEDFRPDVVH 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 103 LNQ-----VEFIDEI----IyssppenRYVFTLHD--PITPEREKIIKALEqrkncYFVSIS----NSQRNNLPFRF-ID 166
Cdd:cd03823   102 THNlsglgASLLDAArdlgI-------PVVHTLHDywLLCPRQFLFKKGGD-----AVLAPSrftaNLHEANGLFSArIS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 167 TVYNGTDLSHYPF-QDVPSD---YLLFMGRIRKEKGLHHAIAVSLRL---NIPLEI--GAPvlniqDSDEYFYKQIRPyl 237
Cdd:cd03823   170 VIPNAVEPDLAPPpRRRPGTerlRFGYIGRLTEEKGIDLLVEAFKRLpreDIELVIagHGP-----LSDERQIEGGRR-- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 238 dnplIGEPGFLEGKNKILLYRQARLLLFPIEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVnsseedKRG 317
Cdd:cd03823   243 ----IAFLGRVPTDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLF------APG 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1083527486 318 DwiikktgIEGLVEAVNKIYSMGEkEYREMRFACRRHVEEKFSVEKMVEGYE 369
Cdd:cd03823   313 D-------AEDLAAAMRRLLTDPA-LLERLRAGAEPPRSTESQAEEYLKLYR 356
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 186-342 5.32e-23

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 93.88  E-value: 5.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 186 YLLFMGRIRKEKGLHHAI--AVSLRLNIPlEIGAPVLNIQDSDEYFYKQIRPYLDNPLIGEPGFLEGKNKILLYRQARLL 263
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIkaFALLKEKNP-NLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083527486 264 LFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVnsseedKRGDWiikktgiEGLVEAVNKIYSMGEK 342
Cdd:pfam00534  83 VLPSRYE-GFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLV------KPNNA-------EALAEAIDKLLEDEEL 147
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 170-369 2.49e-19

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 88.04  E-value: 2.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 170 NGTDLSHYPFQDVPSDY----LLFMGRIRKEKGLHHAIA---------VSLRLNIpleIGAPvlniqDSDEYFYKQIRPY 236
Cdd:cd03808   171 SGVDLDRFQYSPESLPSekvvFLFVARLLKDKGIDELIEaakilkkkgPNVRFLL---VGDG-----ELENPSEILIEKL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 237 LDNPLIGEPGFLegKNKILLYRQARLLLFPIEWEEpFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSseedkr 316
Cdd:cd03808   243 GLEGRIEFLGFR--SDVPELLAESDVFVLPSYREG-LPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVPP------ 313

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1083527486 317 GDWIIKKTGIEGLVEAVNKIYSMGEkeyremrfACRRHVEEKFSVEKMVEGYE 369
Cdd:cd03808   314 GDVEALADAIEKLIEDPELRKEMGE--------AARKRVEEKFDEEKVVNKLL 358
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 255-375 7.00e-19

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 87.00  E-value: 7.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 255 LLYRQARLLLFPiEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVnsseedKRGDwiikktgIEGLVEAVN 334
Cdd:cd03825   259 DIYSAADLFVHP-SLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLV------PPGD-------VQALAEAIE 324

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1083527486 335 KIySMGEKEYREMRFACRRHVEEKFSVEKMVEGYEQVYQRI 375
Cdd:cd03825   325 WL-LANPKERESLGERARALAENHFDQRVQAQRYLELYKDL 364
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 121-375 2.27e-17

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 82.81  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 121 RYVFTLH--D----PITPEREKIIKALEQRKNCY-FVS--ISNSQRNNLPFRF-IDTVYNGTDLSHYPFQD----VPSDY 186
Cdd:cd03798   121 PYVVTEHgsDinvfPPRSLLRKLLRWALRRAARViAVSkaLAEELVALGVPRDrVDVIPNGVDPARFQPEDrglgLPLDA 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 187 --LLFMGRIRKEKGLHHAI-AVSLrlnIPLEIGAPVLNIQDSD---EYFYKQIRPYLDNPLIGEPGFLEGKNKILLYRQA 260
Cdd:cd03798   201 fvILFVGRLIPRKGIDLLLeAFAR---LAKARPDVVLLIVGDGplrEALRALAEDLGLGDRVTFTGRLPHEQVPAYYRAC 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 261 RLLLFPiEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVnsseedKRGDwiiKKTGIEGLVEAVNKIYSMG 340
Cdd:cd03798   278 DVFVLP-SRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLV------PPGD---ADALAAALRRALAEPYLRE 347

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1083527486 341 EKEYREMRFACRrhveekFSVEKMVEGYEQVYQRI 375
Cdd:cd03798   348 LGEAARARVAER------FSWVKAADRIAAAYRDV 376
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 151-375 3.37e-17

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 82.01  E-value: 3.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 151 SISNSQRNNL-----PFRFIDTVYNGTDLSHYPFQDVPSDYLLFMGRiRKEKGLHHaiaVS-LRlnipleigaPVLNIQD 224
Cdd:cd04962   147 AVSSSLRQETyelfdVDKDIEVIHNFIDEDVFKRKPAGALKRRLLAP-PDEKVVIH---VSnFR---------PVKRIDD 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 225 SDEYFY---KQIRPYL----DNP-------LIGEPG------FLEGKNKIL-LYRQARLLLFPIEwEEPFGLVMTEAMAC 283
Cdd:cd04962   214 VVRVFArvrRKIPAKLllvgDGPervpaeeLARELGvedrvlFLGKQDDVEeLLSIADLFLLPSE-KESFGLAALEAMAC 292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 284 GTPVIAFARGSVPEVVVDGVTGFIVNSseedkrGDwiikktgIEGLVEAVNKIYSMGEKeYREMRFACRRHVEEKFSVEK 363
Cdd:cd04962   293 GVPVVSSNAGGIPEVVKHGETGFLSDV------GD-------VDAMAKSALSILEDDEL-YNRMGRAARKRAAERFDPER 358

                         250
                  ....*....|..
gi 1083527486 364 MVEGYEQVYQRI 375
Cdd:cd04962   359 IVPQYEAYYRRL 370
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 188-365 2.27e-16

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 79.63  E-value: 2.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 188 LFMGRIRKEKGLHHAIAVSLRLNIPLEI-GAPVLNiqdsdEYFYKQIRPYLDNP--LIGepgFLEGKNKILLYRQARLLL 264
Cdd:cd03795   195 LFIGRLVYYKGLDYLIEAAQYLNYPIVIgGEGPLK-----PDLEAQIELNLLDNvkFLG---RVDDEEKVIYLHLCDVFV 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 265 FP-IEWEEPFGLVMTEAMACGTPVIAFARG-SVPEVVVDGVTGFIVNSSEEDKrgdwiikktgiegLVEAVNKIYSmGEK 342
Cdd:cd03795   267 FPsVLRSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETGLVVPPKDPDA-------------LAEAIDKLLS-DEE 332

                         170       180
                  ....*....|....*....|...
gi 1083527486 343 EYREMRFACRRHVEEKFSVEKMV 365
Cdd:cd03795   333 LRESYGENAKKRFEELFTAEKMK 355
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 121-370 2.38e-16

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 79.33  E-value: 2.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 121 RYVFTLHD--PIT-----PEREKIIKALEQRKNC----YFVSISNSQRN------NLPFRFIDTVYNGTDLSHYP----- 178
Cdd:cd03809   103 PQVVTIHDliPLRypeffPKRFRLYYRLLLPISLrradAIITVSEATRDdiikfyGVPPEKIVVIPLGVDPSFFPpesaa 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 179 ----FQDVPSDYLLFMGRIRKEKGLH-----HAIAVSLRLNIPLEI-GApvlnIQDSDEYFYKQIRPYLDNPLIGEPGFL 248
Cdd:cd03809   183 vliaKYLLPEPYFLYVGTLEPRKNHErllkaFALLKKQGGDLKLVIvGG----KGWEDEELLDLVKKLGLGGRVRFLGYV 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 249 EGKNKILLYRQARLLLFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFivnsSEEDkrgdwiikktgIEG 328
Cdd:cd03809   259 SDEDLPALYRGARAFVFPSLYE-GFGLPVLEAMACGTPVIASNISVLPEVAGDAALYF----DPLD-----------PES 322

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1083527486 329 LVEAVNKIYSMgEKEYREMRFACRRHVeEKFSVEKMVEGYEQ 370
Cdd:cd03809   323 IADAILRLLED-PSLREELIRKGLERA-KKFSWEKTAEKTLE 362
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 165-370 2.86e-16

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 79.59  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 165 IDTVYNGTDLSHY-PFQD---------VPSD--YLLFMGRIRKEKG---LHHAIAVSLRLNIPLE---IGAPVLNIQDSD 226
Cdd:cd03800   189 INVVPPGVDLERFfPVDRaearrarllLPPDkpVVLALGRLDPRKGidtLVRAFAQLPELRELANlvlVGGPSDDPLSMD 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 227 EYFYKQIRPYLDnpLIGEPGFLEGKNK---ILLYRQARLLLFPiEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGV 303
Cdd:cd03800   269 REELAELAEELG--LIDRVRFPGRVSRddlPELYRAADVFVVP-SLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGR 345

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083527486 304 TGFIVNSSEEDkrgDWIIKktgiegLVEAVNKiysmgEKEYREMRFACRRHVEEKFSVEKMVEGYEQ 370
Cdd:cd03800   346 TGLLVDPHDPE---ALAAA------LRRLLDD-----PALWQRLSRAGLERARAHYTWESVADQLLT 398
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
186-338 4.16e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 74.47  E-value: 4.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 186 YLLFMGRI-RKEKGLH---HAIA------VSLRLNIpleIGApvlniqDSDEYFYKQIRPYLDNPLIgePGFLEGKNKil 255
Cdd:pfam13692   3 VILFVGRLhPNVKGVDyllEAVPllrkrdNDVRLVI---VGD------GPEEELEELAAGLEDRVIF--TGFVEDLAE-- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 256 LYRQARLLLFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEvVVDGVTGFIVNSseedkrGDwiikktgIEGLVEAVNK 335
Cdd:pfam13692  70 LLAAADVFVLPSLYE-GFGLKLLEAMAAGLPVVATDVGGIPE-LVDGENGLLVPP------GD-------PEALAEAILR 134


                  ...
gi 1083527486 336 IYS 338
Cdd:pfam13692 135 LLE 137
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 170-370 1.56e-15

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 77.02  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 170 NGTDLSHYPFQDVPSD---------YLLFMGRIRKEKGLHHAIAVSLRLNiplEIGAPV-LNIQDSDEYFYKQIRPYLDN 239
Cdd:cd03821   181 NGVDIPEFDPGLRDRRkhngledrrIILFLGRIHPKKGLDLLIRAARKLA---EQGRDWhLVIAGPDDGAYPAFLQLQSS 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 240 PLIGE----PGFLEGKNKILLYRQARLLLFPIEwEEPFGLVMTEAMACGTPVIafargsvpevvvdgVTGFiVNSSEEDK 315
Cdd:cd03821   258 LGLGDrvtfTGPLYGEAKWALYASADLFVLPSY-SENFGNVVAEALACGLPVV--------------ITDK-CGLSELVE 321

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1083527486 316 RGDWIIKKTGIEGLVEAVNKI--YSMGEKEYREMRFACrRHVEEKFSVEKMVEGYEQ 370
Cdd:cd03821   322 AGCGVVVDPNVSSLAEALAEAlrDPADRKRLGEMARRA-RQVEENFSWEAVAGQLGE 377
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 187-372 2.29e-15

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 76.56  E-value: 2.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 187 LLFMGRIRKEKGLHHAIAVSLRLniPLEIGAPVLNIQDSDEyfykqiRPYLD--NPLIGEPGFLEGKNKILLYRQARLLL 264
Cdd:cd03814   201 LLYVGRLAPEKNLEALLDADLPL--AASPPVRLVVVGDGPA------RAELEarGPDVIFTGFLTGEELARAYASADVFV 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 265 FPIEwEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEedkrgdwiikktgIEGLVEAVNKiYSMGEKEY 344
Cdd:cd03814   273 FPSR-TETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGD-------------AAAFAAALRA-LLEDPELR 337

                         170       180
                  ....*....|....*....|....*...
gi 1083527486 345 REMRFACRRHVEEkFSVEKMVEGYEQVY 372
Cdd:cd03814   338 RRMAARARAEAER-YSWEAFLDNLLDYY 364
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 256-362 4.59e-15

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 75.78  E-value: 4.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 256 LYRQARLLLFPIEweEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGfivnsseedkrgdWIIKKTGIEGLVEAVNk 335
Cdd:cd03804   262 LLSKARAFVFAAE--EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTG-------------ILFGEQTVESLKAAVE- 325

                          90       100       110
                  ....*....|....*....|....*....|
gi 1083527486 336 iysmgEKEYREMRF---ACRRHVeEKFSVE 362
Cdd:cd03804   326 -----EFEQNFDRFkpqAIRANA-ERFSRA 349
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 253-364 1.05e-14

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 74.93  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 253 KILLYRQARLLLF-PIEweEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEDkrgdwiikktgiegLVE 331
Cdd:cd03805   293 KEQLLSSALALLYtPSN--EHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCEPTPEA--------------FAE 356

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1083527486 332 AVNKIYSMgEKEYREMRFACRRHVEEKFSVEKM 364
Cdd:cd03805   357 AMLKLAND-PDLADRMGAAGRKRVKEKFSREAF 388
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 188-308 4.54e-14

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 70.90  E-value: 4.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 188 LFMGRIRKEKG---LHHAIAVSLRLNIPLE-IGAPVLNIQDSDEYFYKQIRPYLDNPLIGepGFLEGKNKILLYRQARLL 263
Cdd:cd01635   114 VSVGRLVPEKGidlLLEALALLKARLPDLVlVLVGGGGEREEEEALAAALGLLERVVIIG--GLVDDEVLELLLAAADVF 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1083527486 264 LFPIEWEePFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIV 308
Cdd:cd01635   192 VLPSRSE-GFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 121-309 1.69e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 70.85  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 121 RYVFTLHD--PITPEREKIIKALEQRKNcYFVSISNSQRNNLPFRF------IDTVYNGTDLSHYPFQ---------DVP 183
Cdd:cd03819   101 PLVTTVHGsyLATYHPKDFALAVRARGD-RVIAVSELVRDHLIEALgvdperIRVIPNGVDTDRFPPEaeaeeraqlGLP 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 184 SDY--LLFMGRIRKEKGLHHAIAVSLRLNIPLEIGAPVLNIQDSDEYFYKQIRPYLDNPLIGEPGFLEgkNKILLYRQAR 261
Cdd:cd03819   180 EGKpvVGYVGRLSPEKGWLLLVDAAAELKDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGFRE--DVPAALAASD 257

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1083527486 262 LLLFPIEwEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVN 309
Cdd:cd03819   258 VVVLPSL-HEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVP 304
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 279-376 1.89e-13

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 70.91  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 279 EAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEdkrgdwiikktgiEGLVEAVNKIYSMGEKEYREMRfACRRHVEEK 358
Cdd:TIGR03088 291 EAMASGLPVIATAVGGNPELVQHGVTGALVPPGDA-------------VALARALQPYVSDPAARRAHGA-AGRARAEQQ 356

                          90
                  ....*....|....*...
gi 1083527486 359 FSVEKMVEGYEQVYQRIL 376
Cdd:TIGR03088 357 FSINAMVAAYAGLYDQLL 374
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 114-354 2.93e-13

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 70.17  E-value: 2.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 114 YSSPPENRYVFTLHdpitperekiiKALEQRKNCYFVSISNSQRNNL-----PFRFIDTVYNGTDLSHYPFQDV--PSDY 186
Cdd:cd05844   123 LAASPGWPSQFQRH-----------RRALQRPAALFVAVSGFIRDRLlarglPAERIHVHYIGIDPAKFAPRDPaeRAPT 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 187 LLFMGRIRKEKGLHHAIAVSLRLNiPLEIGAPVLNIQDSDEyfykqiRPYLDN--PLIGEPGFL--EGKNKIL-LYRQAR 261
Cdd:cd05844   192 ILFVGRLVEKKGCDVLIEAFRRLA-ARHPTARLVIAGDGPL------RPALQAlaAALGRVRFLgaLPHAEVQdWMRRAE 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 262 LLLFPIEW-----EEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEDKRGDWIIKKTGIEGLVEAvnki 336
Cdd:cd05844   265 IFCLPSVTaasgdSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGDVDALADALQALLADRALADR---- 340

                         250
                  ....*....|....*...
gi 1083527486 337 ysMGEkeyREMRFACRRH 354
Cdd:cd05844   341 --MGG---AARAFVCEQF 353
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 77-353 4.02e-13

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 69.69  E-value: 4.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  77 KIKSSDQLLFSKMMAKGKELSLDIYHLNQveFIDEIIYSSPPENR--YVFTLHDP---ITPEREKIIKALEQRKNC-YFV 150
Cdd:cd03811    63 LIKLGLLKAILKLKRILKRAKPDVVISFL--GFATYIVAKLAAARskVIAWIHSSlskLYYLKKKLLLKLKLYKKAdKIV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 151 SISNSQRNNL------PFRFIDTVYNGTDL--------SHYPFQDVPSDYLLFMGRIRKEKGLHHAIavslrlnipleig 216
Cdd:cd03811   141 CVSKGIKEDLirlgpsPPEKIEVIYNPIDIdriralakEPILNEPEDGPVILAVGRLDPQKGHDLLI------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 217 apvlniqdsdeYFYKQIRPYLDNP---LIGEpGFLEGKNKIL---------------------LYRQARLLLFPIEWEeP 272
Cdd:cd03811   208 -----------EAFAKLRKKYPDVklvILGD-GPLREELEKLakelglaerviflgfqsnpypYLKKADLFVLSSRYE-G 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 273 FGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEDkrgdwiiKKTGIEGLVEAVNKIYSMGEKEYREMRFACR 352
Cdd:cd03811   275 FPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAA-------ALAGILAALLQKKLDAALRERLAKAQEAVFR 347


                  .
gi 1083527486 353 R 353
Cdd:cd03811   348 E 348
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 270-372 5.54e-13

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 69.27  E-value: 5.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 270 EEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGvTGFIVnsSEEDkrgdwiikktgIEGLVEAVNKIYSMGEKeYREMRF 349
Cdd:cd03807   274 TEGFPNALLEAMACGLPVVATDVGGAAELVDDG-TGFLV--PAGD-----------PQALADAIRALLEDPEK-RARLGR 338

                          90       100
                  ....*....|....*....|...
gi 1083527486 350 ACRRHVEEKFSVEKMVEGYEQVY 372
Cdd:cd03807   339 AARERIANEFSIDAMVRRYETLY 361
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 165-372 1.59e-11

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 64.99  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 165 IDTVYNGTDLshYPFQDVPSDY-------------LLFMGRIRKEKGLHHAIAVSLRLNIPLEIGAPVLNIQDSDEYFYK 231
Cdd:cd03817   171 IEVIPNGIDL--DKFEKPLNTEerrklglppdepiLLYVGRLAKEKNIDFLLRAFAELKKEPNIKLVIVGDGPEREELKE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 232 QIRPY--LDNPLigEPGFLEGKNKILLYRQARLLLFPIEwEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVn 309
Cdd:cd03817   249 LARELglADKVI--FTGFVPREELPEYYKAADLFVFAST-TETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLF- 324

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1083527486 310 sseedkrgdwiikKTGIEGLVEAVNKIYSMGEKeYREMRFACRRHVeEKFSVEKMVEGYEQVY 372
Cdd:cd03817   325 -------------EPNDETLAEKLLHLRENLEL-LRKLSKNAEISA-REFAFAKSVEKLYEEV 372
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
113-306 5.95e-11

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 63.27  E-value: 5.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 113 IYSSPPENRYVFTLHDPITPER----EKIIKALEQRKNCYfvsisnsqRNNLPFRFIDTVYNGTDLSHYPFQ-------- 180
Cdd:PRK15484  115 IRERAPQAKLVMHMHNAFEPELldknAKIIVPSQFLKKFY--------EERLPNADISIVPNGFCLETYQSNpqpnlrqq 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 181 -DVPSD--YLLFMGRIRKEKG---LHHAIA--VSLRLNIPLEIGAPVLNIQDSDEYFY-KQIRPYLDNplIGEPGFLEG- 250
Cdd:PRK15484  187 lNISPDetVLLYAGRISPDKGillLMQAFEklATAHSNLKLVVVGDPTASSKGEKAAYqKKVLEAAKR--IGDRCIMLGg 264

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1083527486 251 ---KNKILLYRQARLLLFPIEWEEPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGF 306
Cdd:PRK15484  265 qppEKMHNYYPLADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGY 323
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 256-372 1.81e-10

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 61.69  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 256 LYRQARLLLFPIEWEEpFGLVMTEAMACGTPVIAFARGSVPEVVVDgvtgfivnsseedkrGDWIIKKTGIEGLVEAVNK 335
Cdd:cd04951   259 YYNAADLFVLSSEWEG-FGLVVAEAMACERPVVATDAGGVAEVVGD---------------HNYVVPVSDPQLLAEKIKE 322

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1083527486 336 IYSMGEKEyREMRFACRRHVEEKFSVEKMVEGYEQVY 372
Cdd:cd04951   323 IFDMSDEE-RDILGNKNEYIAKNFSINTIVNEWERLY 358
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 96-369 7.81e-10

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 60.05  E-value: 7.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486  96 LSLDIYHLNQVEFIDEIIYSSPP--------------ENRYVFTLHDpITPE------------REKIIKALEqRKNC-- 147
Cdd:cd03794    86 LAALLKLLVREERPDVIIAYSPPitlglaalllkklrGAPFILDVRD-LWPEslialgvlkkgsLLKLLKKLE-RKLYrl 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 148 --YFVSISNSQRNNLPFRFID-----TVYNGTDLShyPFQDVPSDY------------LLFMGRIRKEKGLHHAIAVSLR 208
Cdd:cd03794   164 adAIIVLSPGLKEYLLRKGVPkekiiVIPNWADLE--EFKPPPKDElrkklglddkfvVVYAGNIGKAQGLETLLEAAER 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 209 LNIPLEI-------GAPVLNIQDSDE------YFYKQIRPYLDNPLIgepgflegknkillYRQARLLLFPIEWEEPFGL 275
Cdd:cd03794   242 LKRRPDIrflfvgdGDEKERLKELAKargldnVTFLGRVPKEEVPEL--------------LSAADVGLVPLKDNPANRG 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 276 V----MTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSseedkrGDwiikktgIEGLVEAVNKIYsMGEKEYREMRFAC 351
Cdd:cd03794   308 SspskLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEP------GD-------PEALADAILELL-DDPELRRAMGENG 373

                         330
                  ....*....|....*...
gi 1083527486 352 RRHVEEKFSVEKMVEGYE 369
Cdd:cd03794   374 RELAEEKFSREKLADRLL 391
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 251-370 1.35e-08

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 56.09  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 251 KNKILLYRQARLLLFPIEWEEpFGLVMTEAMACGTPVIAFARGSVP-EVVVDGVTGFIVNSseedkrGDwiikktgIEGL 329
Cdd:cd03820   247 KNIAEEYANSSIFVLSSRYEG-FPMVLLEAMAYGLPIISFDCPTGPsEIIEDGENGLLVPN------GD-------VDAL 312

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1083527486 330 VEAVNKIysMGEKEYREmRFACR-RHVEEKFSVEKMVEGYEQ 370
Cdd:cd03820   313 AEALLRL--MEDEELRK-KMGKNaRKNAERFSIEKIIKQWEE 351
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 165-372 4.13e-08

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 54.65  E-value: 4.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 165 IDTVYNGTDLSHY-------PFQDVPSdyLLFMGR---IRKEKGLHHAIAVSLRLNIPLE---IGAPvlniqDSDEYFYK 231
Cdd:cd03813   269 TRVIPNGIDIQRFapareerPEKEPPV--VGLVGRvvpIKDVKTFIRAFKLVRRAMPDAEgwlIGPE-----DEDPEYAQ 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 232 QIRPYLDNPLIGEPGFLEGKNKIL-LYRQARLL-LFPIEweEPFGLVMTEAMACGTPVIAFARGSVPEVVVD-----GVT 304
Cdd:cd03813   342 ECKRLVASLGLENKVKFLGFQNIKeYYPKLGLLvLTSIS--EGQPLVILEAMASGVPVVATDVGSCRELIYGaddalGQA 419

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1083527486 305 GFIVnsseedkrgdwiiKKTGIEGLVEAVNKIYSMGEKeYREMRFACRRHVEEKFSVEKMVEGYEQVY 372
Cdd:cd03813   420 GLVV-------------PPADPEALAEALIKLLRDPEL-RQAFGEAGRKRVEKYYTLEGMIDSYRKLY 473
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 271-368 4.95e-08

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 54.29  E-value: 4.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 271 EPFGLV--MTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEDkrgdwiikktgieGLVEAVNKIYSmGEKEYREMR 348
Cdd:cd03818   309 YPFVLSwsLLEAMACGCPVIGSDTAPVREVIRDGRNGLLVDFFDPD-------------ALAAAVLELLE-DPDRAAALR 374

                          90       100
                  ....*....|....*....|
gi 1083527486 349 FACRRHVEEKFSVEKMVEGY 368
Cdd:cd03818   375 RAARRTVERSDSLDVCLARY 394
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 271-359 6.48e-08

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 53.86  E-value: 6.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 271 EPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEDKrgdwiikktgieglVEAVNKIYSmgEKEYREMRFA 350
Cdd:cd03792   290 EGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAA--------------VRILRLLTD--PELRRKMGLA 353


                  ....*....
gi 1083527486 351 CRRHVEEKF 359
Cdd:cd03792   354 AREHVRDNF 362
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 276-364 1.64e-06

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 49.37  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 276 VMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNsseedkrgdwiikktgiEGLVEAVNKI---YSMGEKEYREMRFACR 352
Cdd:cd03799   272 TLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVP-----------------ERDAEAIAEKltyLIEHPAIWPEMGKAGR 334

                          90
                  ....*....|..
gi 1083527486 353 RHVEEKFSVEKM 364
Cdd:cd03799   335 ARVEEEYDINKL 346
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 246-357 2.23e-06

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 49.32  E-value: 2.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 246 GFLEGKNKILLYRQARLLLFPIEwEEPFGLVMTEAMACGTPVIAFARGSVPEVVVD---GVTGFIVNSseedkrGDwiik 322
Cdd:PLN02871  318 GMLQGDELSQAYASGDVFVMPSE-SETLGFVVLEAMASGVPVVAARAGGIPDIIPPdqeGKTGFLYTP------GD---- 386

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1083527486 323 ktgiegLVEAVNKIYSMGE-KEYRE-MRFACRRHVEE 357
Cdd:PLN02871  387 ------VDDCVEKLETLLAdPELRErMGAAAREEVEK 417
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 256-289 1.77e-05

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 46.24  E-value: 1.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1083527486 256 LYRQARLLLFPiEWEEPFGLVMTEAMACGTPVIA 289
Cdd:TIGR04047 273 LYRCADAFAFP-SLKEGFGLVVLEALASGIPVVA 305
PLN00142 PLN00142
sucrose synthase
 271-321 2.45e-05

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 46.51  E-value: 2.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1083527486 271 EPFGLVMTEAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEDKRGDWII 321
Cdd:PLN00142  677 EAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGFHIDPYHGDEAANKIA 727
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 136-344 7.70e-05

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 44.21  E-value: 7.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 136 KIIKALEQRKncyfVSISNSQRNNLPFRFIDTVYNGTDLSHYPFQDVPSDYLLFMGRIRKEKGLHHAI-AVSLRL----N 210
Cdd:cd04949   116 AIIVSTEQQK----QDLSERFNKYPPIFTIPVGYVDQLDTAESNHERKSNKIITISRLAPEKQLDHLIeAVAKAVkkvpE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 211 IPLEI---GAPVLNIQDSDEYF----YKQIRPYLDNPLIgepgflegknkilLYRQARLLLFPIEWEEpFGLVMTEAMAC 283
Cdd:cd04949   192 ITLDIygyGEEREKLKKLIEELhledNVFLKGYHSNLDQ-------------EYQDAYLSLLTSQMEG-FGLTLMEAIGH 257

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1083527486 284 GTPVIAF-ARGSVPEVVVDGVTGFIVNSSEEDKRGDWIIKktgiegLVEAVNKIYSMGEKEY 344
Cdd:cd04949   258 GLPVVSYdVKYGPSELIEDGENGYLIEKNNIDALADKIIE------LLNDPEKLQQFSEESY 313
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
279-377 1.24e-04

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 40.67  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 279 EAMACGTPVIAFARGSVPEVVVDGVTGFIVNSSEEdkrgdwiikktgiegLVEAVNKiYSMGEKEYREMRFACRRHVEEK 358
Cdd:pfam13524  18 EAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEE---------------LAEKIRY-LLEHPEERRAIAAAGRERVLAE 81

                          90
                  ....*....|....*....
gi 1083527486 359 FSvekmvegYEQVYQRILN 377
Cdd:pfam13524  82 HT-------YAHRAEQLLD 93
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 246-363 8.67e-04

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 41.29  E-value: 8.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 246 GFLEGKNKILLYRQARLLLFpIEWEEPFGL---VMtEAMACGTPVIAFARGSVPEVVVDGVTGFIVNsseedkrgdwiiK 322
Cdd:cd04946   289 GEVSNKEVKQLYKENDVDVF-VNVSESEGIpvsIM-EAISFGIPVIATNVGGTREIVENETNGLLLD------------K 354

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1083527486 323 KTGIEGLVEAVNKIYSMGEKeYREMRFACRRHVEEKFSVEK 363
Cdd:cd04946   355 DPTPNEIVSSIMKFYLDGGD-YKTMKISARECWEERFNAEV 394
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
271-379 2.46e-03

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 39.69  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 271 EPFGLVMTEAMACGTPVIAFARGSVPE-VVVDGVTGfivnssEEDKRGDwiikktgIEGLVEAVNKIYSmGEKEYremrf 349
Cdd:PRK09922  268 EGFPMTLLEAMSYGIPCISSDCMSGPRdIIKPGLNG------ELYTPGN-------IDEFVGKLNKVIS-GEVKY----- 328

                          90       100       110
                  ....*....|....*....|....*....|
gi 1083527486 350 acrRHVEEKFSVEKMvegYEQVYQRILNKL 379
Cdd:PRK09922  329 ---QHDAIPNSIERF---YEVLYFKNLNNA 352
GT33_ALG1-like cd03816
chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is ...
 283-313 2.48e-03

chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; This family is most closely related to the GT33 family of glycosyltransferases. The yeast gene ALG1 has been shown to function as a mannosyltransferase that catalyzes the formation of dolichol pyrophosphate (Dol-PP)-GlcNAc2Man from GDP-Man and Dol-PP-Glc-NAc2, and participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. In humans ALG1 has been associated with the congenital disorders of glycosylation (CDG) designated as subtype CDG-Ik.


Pssm-ID: 340843 [Multi-domain]  Cd Length: 411  Bit Score: 39.56  E-value: 2.48e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1083527486 283 CGTPVIAFARGSVPEVVVDGVTGFIVNSSEE 313
Cdd:cd03816   337 CGLPVCAMDFKCIGELVKHGVNGLVFGDSEE 367
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 269-363 3.08e-03

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 39.51  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527486 269 WEEPFGLVMTEAMACGTPVIAFARGSvPE--VVV---DGVTGFIVNSSEEDkrgdwiikktgieglVEAVNKIYSMGEKE 343
Cdd:cd03806   333 WNEHFGIGVVEYMAAGLIPLAHASAG-PLldIVVpwdGGPTGFLASTPEEY---------------AEAIEKILTLSEEE 396

                          90       100
                  ....*....|....*....|
gi 1083527486 344 yREMRFACRRHVEEKFSVEK 363
Cdd:cd03806   397 -RLQRREAARSSAERFSDEE 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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