|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
1-499 |
0e+00 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 518.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 1 MTLISRVSGLVRDMAFASLIGAGsgIAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSRDDGDATRAFLDHMAGW 80
Cdd:COG0728 10 GTLLSRILGFVRDILIAAAFGAG--AVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRFASRVLTL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 81 LMLALLVVTVVGVLAAPLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLC 160
Cdd:COG0728 88 LLLVLLVLTLLGILFAPLLVKLLAPGF--DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALAPVLLNLV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 161 LIVAALWWAHHTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRpfHEGVMRVLRLMGPAIFGVSVAQVNLL 240
Cdd:COG0728 166 IIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLR--DPGVRRVLKLMLPALLGVSVSQINLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 241 INTLLASFLITGSVAWLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:COG0728 244 VDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:COG0728 324 AEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHA 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRRANAYRPLPGWAGFAARIVAASAVMGVLLFFGTGALEHWLAMSGWQRAGHLSFWIAAG 480
Cdd:COG0728 404 GLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVG 483
|
490
....*....|....*....
gi 1083760537 481 IVVYVVTILLLGIRPAQLL 499
Cdd:COG0728 484 AAVYFALLLLLGVRLRDLL 502
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
1-423 |
9.04e-161 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 462.69 E-value: 9.04e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 1 MTLISRVSGLVRDMAFASLIGAGsgIAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSRDDGDATRAFLDHMAGW 80
Cdd:cd13123 3 GTLLSRILGFVRDVLIAAAFGAG--PLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 81 LMLALLVVTVVGVLAAPLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLC 160
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF--SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 161 LIVAALWWAHHTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRpfHEGVMRVLRLMGPAIFGVSVAQVNLL 240
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFR--DPGVRRVLKLMLPALLGVSVSQINLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 241 INTLLASFLITGSVAWLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:cd13123 237 VDTILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:cd13123 317 AEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHV 396
|
410 420
....*....|....*....|...
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRR 423
Cdd:cd13123 397 GLALATSLSAWVNALLLLVLLRR 419
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
1-500 |
5.09e-124 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 372.04 E-value: 5.09e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 1 MTLISRVSGLVRDMAFASLIGAGSgiAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSRDDgDATRAFLDHMAGW 80
Cdd:TIGR01695 12 GTLFSRITGFVRDAIIASAFGAGL--TADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEK-EARRAFANTVTTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 81 LMLALLVVTVVGVLAAPLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLC 160
Cdd:TIGR01695 89 LILSLLLVVLIGIFFAPFVISLLAPGF--ADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSFSPILFNIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 161 LIVAALWWAHHTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRpfHEGVMRVLRLMGPAIFGVSVAQVNLL 240
Cdd:TIGR01695 167 VILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFR--DPGLKRFLKLFLPTTLGSSASQITLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 241 INTLLASFLITGSVAWLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:TIGR01695 245 INTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLIL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:TIGR01695 325 SIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLV 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRRANAYRPLPGWAGFAARIVAASAVMGVLLFFgTGALEHWLAMSgwQRAGHLSFWIAAG 480
Cdd:TIGR01695 405 GIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYL-IVSVSLGGVLV--KNLLGLLAIGLIG 481
|
490 500
....*....|....*....|
gi 1083760537 481 IVVYVVTILLLGIRPAQLLL 500
Cdd:TIGR01695 482 LLVYFLGLALLKIEELNLLL 501
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
16-454 |
3.41e-122 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 365.46 E-value: 3.41e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 16 FASLIGAGSgiAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSrDDGDATRAFLDHMAGWLMLALLVVTVVGVLA 95
Cdd:pfam03023 1 IAAYFGAGL--LSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKA-QDKEEAAEFVRKVSTLLILVLLLVTLIGILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 96 APLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWAHHTTPA 175
Cdd:pfam03023 78 APWLIRLLAPGF--DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 176 VKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRPfhEGVMRVLRLMGPAIFGVSVAQVNLLINTLLASFLITGSVA 255
Cdd:pfam03023 156 IYALAIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRD--KGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 256 WLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLATLFHYGAFH 335
Cdd:pfam03023 234 YLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 336 GHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHVGLALAISLAAFVNAG 415
Cdd:pfam03023 314 PEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLV 393
|
410 420 430
....*....|....*....|....*....|....*....
gi 1083760537 416 LLYHHLRRANAYRPLPGWAGFAARIVAASAVMGVLLFFG 454
Cdd:pfam03023 394 FLYYILRKRLGGFDLRGIKTFLASLVVPTALMAGVILLL 432
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
1-499 |
0e+00 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 518.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 1 MTLISRVSGLVRDMAFASLIGAGsgIAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSRDDGDATRAFLDHMAGW 80
Cdd:COG0728 10 GTLLSRILGFVRDILIAAAFGAG--AVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKEGEEEARRFASRVLTL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 81 LMLALLVVTVVGVLAAPLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLC 160
Cdd:COG0728 88 LLLVLLVLTLLGILFAPLLVKLLAPGF--DPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALAPVLLNLV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 161 LIVAALWWAHHTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRpfHEGVMRVLRLMGPAIFGVSVAQVNLL 240
Cdd:COG0728 166 IIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLR--DPGVRRVLKLMLPALLGVSVSQINLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 241 INTLLASFLITGSVAWLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:COG0728 244 VDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:COG0728 324 AEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHA 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRRANAYRPLPGWAGFAARIVAASAVMGVLLFFGTGALEHWLAMSGWQRAGHLSFWIAAG 480
Cdd:COG0728 404 GLALATSLSALVNALLLLVLLRRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVG 483
|
490
....*....|....*....
gi 1083760537 481 IVVYVVTILLLGIRPAQLL 499
Cdd:COG0728 484 AAVYFALLLLLGVRLRDLL 502
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
1-423 |
9.04e-161 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 462.69 E-value: 9.04e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 1 MTLISRVSGLVRDMAFASLIGAGsgIAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSRDDGDATRAFLDHMAGW 80
Cdd:cd13123 3 GTLLSRILGFVRDVLIAAAFGAG--PLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKEGEEEARRFASRVLTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 81 LMLALLVVTVVGVLAAPLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLC 160
Cdd:cd13123 81 LLLVLLLLTLLGILFAPLLVKLLAPGF--SGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 161 LIVAALWWAHHTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRpfHEGVMRVLRLMGPAIFGVSVAQVNLL 240
Cdd:cd13123 159 IIAGLLLLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFR--DPGVRRVLKLMLPALLGVSVSQINLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 241 INTLLASFLITGSVAWLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:cd13123 237 VDTILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:cd13123 317 AEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHV 396
|
410 420
....*....|....*....|...
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRR 423
Cdd:cd13123 397 GLALATSLSAWVNALLLLVLLRR 419
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
1-500 |
5.09e-124 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 372.04 E-value: 5.09e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 1 MTLISRVSGLVRDMAFASLIGAGSgiAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSRDDgDATRAFLDHMAGW 80
Cdd:TIGR01695 12 GTLFSRITGFVRDAIIASAFGAGL--TADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEK-EARRAFANTVTTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 81 LMLALLVVTVVGVLAAPLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLC 160
Cdd:TIGR01695 89 LILSLLLVVLIGIFFAPFVISLLAPGF--ADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSFSPILFNIG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 161 LIVAALWWAHHTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRpfHEGVMRVLRLMGPAIFGVSVAQVNLL 240
Cdd:TIGR01695 167 VILSLLFFDWNYGQYSLALAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFR--DPGLKRFLKLFLPTTLGSSASQITLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 241 INTLLASFLITGSVAWLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:TIGR01695 245 INTALASFLEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLIL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:TIGR01695 325 SIPIVSLLFERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLV 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRRANAYRPLPGWAGFAARIVAASAVMGVLLFFgTGALEHWLAMSgwQRAGHLSFWIAAG 480
Cdd:TIGR01695 405 GIALATSAASMVSSVLLYLMLNRRLKGILPFGVLKVLAKLVIASAIIGGVLYL-IVSVSLGGVLV--KNLLGLLAIGLIG 481
|
490 500
....*....|....*....|
gi 1083760537 481 IVVYVVTILLLGIRPAQLLL 500
Cdd:TIGR01695 482 LLVYFLGLALLKIEELNLLL 501
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
16-454 |
3.41e-122 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 365.46 E-value: 3.41e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 16 FASLIGAGSgiAADAFYVAFRIPNFLRRIFGEGAFSQAFVPVLSQYRSrDDGDATRAFLDHMAGWLMLALLVVTVVGVLA 95
Cdd:pfam03023 1 IAAYFGAGL--LSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKA-QDKEEAAEFVRKVSTLLILVLLLVTLIGILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 96 APLLVTVLAPGFigAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWAHHTTPA 175
Cdd:pfam03023 78 APWLIRLLAPGF--DPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGNA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 176 VKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRPfhEGVMRVLRLMGPAIFGVSVAQVNLLINTLLASFLITGSVA 255
Cdd:pfam03023 156 IYALAIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRD--KGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 256 WLYYADRLMEFPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLATLFHYGAFH 335
Cdd:pfam03023 234 YLYYADRIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 336 GHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHVGLALAISLAAFVNAG 415
Cdd:pfam03023 314 PEDVTATAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLLPPLGVAGLALATSLSSLIGLV 393
|
410 420 430
....*....|....*....|....*....|....*....
gi 1083760537 416 LLYHHLRRANAYRPLPGWAGFAARIVAASAVMGVLLFFG 454
Cdd:pfam03023 394 FLYYILRKRLGGFDLRGIKTFLASLVVPTALMAGVILLL 432
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
103-493 |
3.88e-22 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 99.47 E-value: 3.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 103 LAPGFIGAPDkfalTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPV---LLNLCLIVAALWWAHHTTP--AVK 177
Cdd:COG5841 110 IARLLLGDPR----AYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQVieqIVRVIFILLLAYLLLPYGLeyAAA 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 178 ALAWGVFAAGVVQLLFQIPFLAR------LGLLPSPRLSWRPFHEGVMRVLRLMGPAIFGVSVAQV-----NLLINTLLA 246
Cdd:COG5841 186 GATFGAVIGALAGLLVLLYYYRKrkkklkRLLEKSKTKSKESSKDILKELLRIAIPITLSSLVLPLfqlidSFTVPRRLQ 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 247 SFLITGSVAWLYY------ADRLMEFPLgIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVL 320
Cdd:COG5841 266 AAGLSASEATSLYgilsgmAQPLVNLPT-VLATALATSLVPAISEAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVL 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 321 AGPMLATLFHYGAfhghdvlmSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHV 400
Cdd:COG5841 345 AEPINTLLFGNPE--------GGGILAILAPSAIFLSLQQVTTGILQGLGKQKIPVINLLIGLLVKIILNYLLVPLFGIY 416
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 401 GLALAISLAAFVNAGLLYHHLRRANAYRplPGWAGFAARIVAASAVMGVLLFFGTGALEHWLAMSGWQRAGHLSFWIAAG 480
Cdd:COG5841 417 GAALATVIGYLVAAILNLAALKKYTGFK--LDLRRRLLKPLLASLIMGIVVLLLYRLLSLFLPESRLGALLATLIAVLVG 494
|
410
....*....|...
gi 1083760537 481 IVVYVVTILLLGI 493
Cdd:COG5841 495 AIVYLLLLLKLGL 507
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
98-422 |
2.30e-19 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 89.91 E-value: 2.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 98 LLVTVLAPGFIGapDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWAHhTTPAVK 177
Cdd:cd13128 91 LLLLFLFAFLIA--FYDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALILVL-LGGGLI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 178 ALAWGVFAAGVVQLLFQIPFLARLGLLPSprlSWRPFHEGVMRVLRLMGPAIFGVSVAQVNLLINT-LLASFLITGSVAW 256
Cdd:cd13128 168 GFALAYLIASVLSAILLLYIYRKKILLPK---FFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTiMLGYFLGDAAVGI 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 257 LYYADRLMEFpLGIFGIALATVILPSLSRRHANNsHEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLATLFhygafhG 336
Cdd:cd13128 245 YNAAYRIAEL-LLFIPSAISTALFPRISELYKND-KDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLF------G 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 337 HDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHVGLALAISLAAFVNAGL 416
Cdd:cd13128 317 EEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFIL 396
|
....*.
gi 1083760537 417 LYHHLR 422
Cdd:cd13128 397 LLYLLK 402
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
121-423 |
1.58e-18 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 87.91 E-value: 1.58e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 121 LRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNL----CLIVAALWWAHHTTPAVKALAWGVFAA---GVVQLLF 193
Cdd:cd13124 114 IRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIvrviVILVLAYLLLPVGGGLYYAAAGATFGAvigALAGLLV 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 194 QIPFLARLG-----LLPSPRLSWRPFHEGVMRVLRLMGPAIFG---VSVAQV--NLLINTLLASFLITGSVAWL---YYA 260
Cdd:cd13124 194 LLYYYRKKRrelkrLLRKSPRSKISTKEILKELLSYAIPITLSsliLPLLQLidSFTVPRRLQAAGLSESEATAlygILT 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 261 DR---LMEFPLgIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLATLFHYGAfhgh 337
Cdd:cd13124 274 GRaqpLVQLPT-VIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE---- 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 338 dvlmSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHVGLALAISLAAFVNAGLL 417
Cdd:cd13124 349 ----GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLN 424
|
....*.
gi 1083760537 418 YHHLRR 423
Cdd:cd13124 425 LRALKK 430
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
98-418 |
5.23e-12 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 67.28 E-value: 5.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 98 LLVTVLAPGFIGAPDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWAhhttpavk 177
Cdd:COG2244 94 ALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALLLA-------- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 178 ALAWGVFAAgvvqllfqipflarlgllpsprlswrpfhegvmrVLRLMGPAIFGVSVAQVNLLINTLLASFLIT-GSVAW 256
Cdd:COG2244 166 LLGLGLWGL----------------------------------VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGpAAVGI 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 257 LYYADRLMEFPLgIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLATLFhygafhG 336
Cdd:COG2244 212 YSAAYRLASLLL-LLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLF------G 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 337 HDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHVGLALAISLAAFVNAGL 416
Cdd:COG2244 285 PEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLL 364
|
..
gi 1083760537 417 LY 418
Cdd:COG2244 365 LL 366
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
118-423 |
6.31e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 54.80 E-value: 6.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 118 VDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWAHhTTPAVKALAWGVFAAGVVQLLFqipF 197
Cdd:cd13127 106 IPLLRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTLVSGVVAIVLAL-LGFGVWALVAQQLVGALVSTVL---L 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 198 LARLGLLPSPRLSWRPFHEGVMRVLRLMGPAIFGVSVAQVNLLIntlLASFLITGSVAWLYYADRLMEFPLGIFGIALAT 277
Cdd:cd13127 182 WILSRWRPRLSFSLASLKELLSFGSKLLGSNLLNYFSRNLDNLI---IGKFLGAAALGYYSRAYRLALLPVQNITGPITR 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 278 VILPSLSRRHANNshEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLATLFhygafhGHDVLMSARALMAFSLGLLGFI 357
Cdd:cd13127 259 VLFPALSRLQDDP--ERLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLL------GEKWLPAVPILQILALAGLFQP 330
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1083760537 358 FVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVwPLKHVGLALAISLAAFVNAGLLYHHLRR 423
Cdd:cd13127 331 LSSLNGSLLLALGRTDLLLKLGLIKAVLTVLALLIGI-PYGIIGVAIAYVIASLLSFPLNLYLAGR 395
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
345-493 |
1.96e-07 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 50.26 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 345 ALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKHVGLALAISLAAFVNAGLLYHHLRRA 424
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083760537 425 NAYRPLPGWAGfaaRIVAASAVMGVLLFfgtgaLEHWLAMSGWQRAGHLSFWIAAGIVVYVVTILLLGI 493
Cdd:pfam14667 81 LGLRLLLRRLL---KPLLAALVMGIVVY-----LLLLLLGLLLGLALALLLAVLVGALVYLLLLLLLKL 141
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
97-417 |
9.63e-07 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 51.17 E-value: 9.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 97 PLLVTVLAPGFIGA----PDKFALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWAH-- 170
Cdd:cd12082 89 AALLLFFSPLILSLlgaeEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIFgl 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 171 -HTTPAVKALAWGVFAAGVVQLLFQIPFLARLGLLPSPRLSWRPFHEGVMRVLRLMG-PAIFGVSVAQVNLLINTLLASF 248
Cdd:cd12082 169 gPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGlPSAIQNSLLSLGLLIIVAIVAA 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 249 LI-TGSVAWLYYADRLMEFPLGIFgIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLAT 327
Cdd:cd12082 249 FGgAAALAAYTVAFRIASLAFMPA-LGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSL 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 328 LFHYGAFhghdVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLAL--VWPLKHVGLALA 405
Cdd:cd12082 328 FTNDPEF----LELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVlaYLGLGLYGIWLA 403
|
330
....*....|..
gi 1083760537 406 ISLAAFVNAGLL 417
Cdd:cd12082 404 LVISLILAALVL 415
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
220-423 |
4.01e-06 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 48.99 E-value: 4.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 220 RVLRLMGPAIFGVSVAQVNLLINTLLASFLITGSVAWLYYADRLMeFPLGIFGIALATVILPSLSRRHANNSHEDFSHLI 299
Cdd:COG0534 9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIF-FLLIALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 300 DWALRWVLLIGLPATVGLMVLAGPMLATLfhyGAfhGHDVLMSARA-LMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRI 378
Cdd:COG0534 88 GQALLLALLLGLLLTLLGLLFAPPLLRLL---GA--DPEVLALARDyLRIILLGLPFLLLFNVLNGILRGLGDTKTPMII 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1083760537 379 GVIAMAVNIVLSLALVWPLKH--VGLALAISLAAFVNAGLLYHHLRR 423
Cdd:COG0534 163 MLIGNVLNIVLDPLLIFGGGLgvAGAALATVISQAVSALLLLYYLFR 209
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
266-436 |
3.17e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 46.34 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 266 FPLGIFGIALATVILPSLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVGLmvLAGPMLATLFHYGAfhgHDVLMSARA 345
Cdd:cd13131 49 FPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPLMLLL--WLAPPILPLMGQEP---EVAAIARGY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 346 LMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVW------PLKHVGLALAISLAAFVNAGLLYH 419
Cdd:cd13131 124 LLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIFgkfglpALGGAGAGLATAIVYWLMFLALAF 203
|
170
....*....|....*..
gi 1083760537 420 HLRRANAYRPLPGWAGF 436
Cdd:cd13131 204 YIRRHKRFRRYRLFARF 220
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
220-423 |
4.68e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.97 E-value: 4.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 220 RVLRLMGPAIFGVSVAQVNLLINTLLASFLITGSVAWLYYADRLMEFPLGIF-GIALATVILpsLSRRHANNSHEDFSHL 298
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNmALGTGTVAL--VSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 299 IDWALRWVLLIGLPATVGLMVLAGPMLATLFHYGAFhghdVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRI 378
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEV----IALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYI 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1083760537 379 GVIAMAVNIVLSLALV---WPLKH---VGLALAISLAAFVNAGLLYHHLRR 423
Cdd:cd13137 156 MIIVNVLNIVLDYVLIfglWGFPGlgvAGAALATVISRVVGALLLLFLLLR 206
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
106-418 |
1.55e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 43.98 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 106 GFIGAPDK-FALTVDMLRIMFPYIFFVSLVAMAAGVLNAWGRFAAAAFTPVLLNLCLIVAALWWahhttpaVKALAWGVF 184
Cdd:COG0534 114 RLLGADPEvLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLL-------IFGGGLGVA 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 185 AAG-------VVQLLFQIPFLAR-LGLLPSPRLSWRPFHEGVMRVLRLMGPAIFGVSVAQVNLLINTLLASFLITGSVAW 256
Cdd:COG0534 187 GAAlatvisqAVSALLLLYYLFRkRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 257 LYYADRLMEFP-LGIFGIALATVILpsLSRRHANNSHEDFSHLIDWALRWVLLIGLPATVgLMVLAGPMLATLFHYGAfh 335
Cdd:COG0534 267 YGIALRIESLAfMPALGLGQAAQPL--VGQNLGAGDYDRARRAARLALLLALGIGLLLAL-LLFLFPEPIIGLFTDDP-- 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 336 ghDVL-MSARALMAFSLGLLGFIFVKVLAPGFYAREDTKTPMRIGVIAMAVNIVLSLALVWPLKH--VGLALAISLAAFV 412
Cdd:COG0534 342 --EVIaLAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLglTGVWLALPIGEVL 419
|
....*.
gi 1083760537 413 NAGLLY 418
Cdd:COG0534 420 RALLLL 425
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
220-467 |
6.10e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 42.13 E-value: 6.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 220 RVLRLMGPAIFGVSVAQVNLLINTL---------LASFLITGSVAWLYYAdrlmefplGIFGIALATVILpsLSRRHANN 290
Cdd:cd13133 6 EILKIALPLVLSMLSQTVMGFTDRAflgrlsevaLAASGPAGVLYFAILM--------LFFGLSSGVQVF--VAQYNGAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 291 SHEDFSHLIDWALrWVLLIGLPATVGLMVLAGPMLATLFhygaFHGHDVLMSARALMAFSLGLLGFIFVKVLAPGFY-AR 369
Cdd:cd13133 76 RYSRIGRVLWQGL-YFSLLLAPLLALLSALAAPLLFLLL----GHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFsGI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 370 EDTKTPMRIGVIAMAVNIVLSLALV---WPLKHVGL---ALAISLAAFVNAGLLYHHLRRANAYRPLPGWAGFAARIvaa 443
Cdd:cd13133 151 GRTRVVMVANLVMVVVNIVLDYALIfgkLGFPAMGIagaAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAWRFDR--- 227
|
250 260
....*....|....*....|....*
gi 1083760537 444 sAVMGVLLFFGT-GALEHWLAMSGW 467
Cdd:cd13133 228 -ELLRRILRLGLpSGLQFFLDVGAF 251
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
293-423 |
7.91e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 41.74 E-value: 7.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083760537 293 EDFSHLIDWALRWVLLIGLPATVGLMVLAGPMLAtLFHYGAfhGHDVLMSARALMAFSLGLLGFIFVKVLAPGFYAREDT 372
Cdd:cd13140 78 KEARKYARNALQLNLLLGILYGLLLLLFAKPLIG-FFNLGD--AEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDS 154
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1083760537 373 KTPMRIGVIAMAVNIVLSLALV---WPLKH---VGLALAISLAAFVNAGLLYHHLRR 423
Cdd:cd13140 155 KTPFIINAIGLVLNIILDPLLIfgfGPFPAlgvAGAALATVLAQAIVFLLFLYALKK 211
|
|
| |
