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Conserved domains on  [gi|1084826801|gb|OGQ60551|]
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hypothetical protein A3J24_08640 [Deltaproteobacteria bacterium RIFCSPLOWO2_02_FULL_53_8]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11495466)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TonB_2 pfam13103
TonB C terminal; This family contains TonB members that are not captured by pfam03544.
 196-266 2.77e-18

TonB C terminal; This family contains TonB members that are not captured by pfam03544.


:

Pssm-ID: 463788 [Multi-domain]  Cd Length: 85  Bit Score: 77.37  E-value: 2.77e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084826801 196 YRAYYALIRDKVQENWRYPYKDDKVM-IIVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLP 266
Cdd:pfam13103   1 YDEYAAKVRAIIRENWAPPSGISGNLeAVVEITIDPDGTIVSVRLVKSSGNEAFDKAVLRALEKSSPLPPPP 72
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 102-266 4.92e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 50.23  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084826801 102 KAIKIKTAKAHDTASVDLALKKIEKSLQKKADADLVSARIETIKKSRDNTAAKNTSAAVDEIKRRIASQ--SQSKGMQTA 179
Cdd:TIGR02794 159 KAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERkaDEAELGDIF 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084826801 180 GRTGGPNASREALETQYRA------YYALIRDKVQENWRYPYKDDKVMIIVYIKIAGDGRVVSsrIEESSGNGLFDESLL 253
Cdd:TIGR02794 239 GLASGSNAEKQGGARGAAAgsevdkYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDGTLLS--VTKSSGDPALCQAAL 316

                         170
                  ....*....|...
gi 1084826801 254 GAIKKASPFaPLP 266
Cdd:TIGR02794 317 AAVAKAAKL-PMP 328
 
Name Accession Description Interval E-value
TonB_2 pfam13103
TonB C terminal; This family contains TonB members that are not captured by pfam03544.
 196-266 2.77e-18

TonB C terminal; This family contains TonB members that are not captured by pfam03544.


Pssm-ID: 463788 [Multi-domain]  Cd Length: 85  Bit Score: 77.37  E-value: 2.77e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084826801 196 YRAYYALIRDKVQENWRYPYKDDKVM-IIVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLP 266
Cdd:pfam13103   1 YDEYAAKVRAIIRENWAPPSGISGNLeAVVEITIDPDGTIVSVRLVKSSGNEAFDKAVLRALEKSSPLPPPP 72
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 221-272 1.39e-08

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 50.76  E-value: 1.39e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084826801 221 MIIVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLPQGFPEA 272
Cdd:TIGR01352  11 TVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPPPPPGGVVA 62
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 223-270 5.87e-08

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 48.74  E-value: 5.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1084826801 223 IVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLPQGFP 270
Cdd:COG0810    14 TVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPAKQNGKP 61
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 102-266 4.92e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 50.23  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084826801 102 KAIKIKTAKAHDTASVDLALKKIEKSLQKKADADLVSARIETIKKSRDNTAAKNTSAAVDEIKRRIASQ--SQSKGMQTA 179
Cdd:TIGR02794 159 KAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERkaDEAELGDIF 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084826801 180 GRTGGPNASREALETQYRA------YYALIRDKVQENWRYPYKDDKVMIIVYIKIAGDGRVVSsrIEESSGNGLFDESLL 253
Cdd:TIGR02794 239 GLASGSNAEKQGGARGAAAgsevdkYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDGTLLS--VTKSSGDPALCQAAL 316

                         170
                  ....*....|...
gi 1084826801 254 GAIKKASPFaPLP 266
Cdd:TIGR02794 317 AAVAKAAKL-PMP 328
 
Name Accession Description Interval E-value
TonB_2 pfam13103
TonB C terminal; This family contains TonB members that are not captured by pfam03544.
 196-266 2.77e-18

TonB C terminal; This family contains TonB members that are not captured by pfam03544.


Pssm-ID: 463788 [Multi-domain]  Cd Length: 85  Bit Score: 77.37  E-value: 2.77e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084826801 196 YRAYYALIRDKVQENWRYPYKDDKVM-IIVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLP 266
Cdd:pfam13103   1 YDEYAAKVRAIIRENWAPPSGISGNLeAVVEITIDPDGTIVSVRLVKSSGNEAFDKAVLRALEKSSPLPPPP 72
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 221-272 1.39e-08

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 50.76  E-value: 1.39e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084826801 221 MIIVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLPQGFPEA 272
Cdd:TIGR01352  11 TVVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPPPPPGGVVA 62
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 223-270 5.87e-08

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 48.74  E-value: 5.87e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1084826801 223 IVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLPQGFP 270
Cdd:COG0810    14 TVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPAKQNGKP 61
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 102-266 4.92e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 50.23  E-value: 4.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084826801 102 KAIKIKTAKAHDTASVDLALKKIEKSLQKKADADLVSARIETIKKSRDNTAAKNTSAAVDEIKRRIASQ--SQSKGMQTA 179
Cdd:TIGR02794 159 KAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERkaDEAELGDIF 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084826801 180 GRTGGPNASREALETQYRA------YYALIRDKVQENWRYPYKDDKVMIIVYIKIAGDGRVVSsrIEESSGNGLFDESLL 253
Cdd:TIGR02794 239 GLASGSNAEKQGGARGAAAgsevdkYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDGTLLS--VTKSSGDPALCQAAL 316

                         170
                  ....*....|...
gi 1084826801 254 GAIKKASPFaPLP 266
Cdd:TIGR02794 317 AAVAKAAKL-PMP 328
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 222-270 4.49e-05

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 41.11  E-value: 4.49e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1084826801 222 IIVYIKIAGDGRVVSSRIEESSGNGLFDESLLGAIKKASPFAPLPQGFP 270
Cdd:pfam03544  18 VVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKKWRFKPAPKNGQP 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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