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Conserved domains on  [gi|1084827064|gb|OGQ60787|]
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tol-pal system protein YbgF [Deltaproteobacteria bacterium RIFCSPLOWO2_02_FULL_53_8]

Protein Classification

tol-pal system YbgF family protein( domain architecture ID 11448200)

tol-pal system YbgF family protein is a tetratricopeptide repeat-containing protein that interacts with TolA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 155-260 1.93e-34

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 120.48  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 155 QDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVEL 234
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLEL 80

                          90       100
                  ....*....|....*....|....*.
gi 1084827064 235 NDSDKAEEAFSTLLKRYPKSQAAVKA 260
Cdd:COG1729    81 GDYDKARATLEELIKKYPDSEAAKEA 106
 
Name Accession Description Interval E-value
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 155-260 1.93e-34

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 120.48  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 155 QDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVEL 234
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLEL 80

                          90       100
                  ....*....|....*....|....*.
gi 1084827064 235 NDSDKAEEAFSTLLKRYPKSQAAVKA 260
Cdd:COG1729    81 GDYDKARATLEELIKKYPDSEAAKEA 106
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 149-260 2.82e-34

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 120.08  E-value: 2.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 149 ALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAG 228
Cdd:TIGR02795   2 AYYDAALLVLKAGDYADAIQAFQAFLKKYPKSTYAPNAHYWLGEAYYAQGDYADAAKAFLAVVKKYPKSPKAPDALLKLG 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1084827064 229 YSYVELNDSDKAEEAFSTLLKRYPKSQAAVKA 260
Cdd:TIGR02795  82 MSLQELGDKEKAKATLQQVIKRYPGSSAAKLA 113
PRK10803 PRK10803
tol-pal system protein YbgF; Provisional
 97-260 8.42e-16

tol-pal system protein YbgF; Provisional


Pssm-ID: 182745 [Multi-domain]  Cd Length: 263  Bit Score: 75.22  E-value: 8.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064  97 TLSGGEGKQPSATPAQPEKAAkkakhDNTVVVSKGQDSEASPELTGD-NEGPDALYSRGQDlfmAGRYDESREVFSRLAS 175
Cdd:PRK10803  100 SLSSGGAAAQSTSGDQSGAAA-----SATPAADAGTANAGAPVQSGDaNTDYNAAIALVQD---KSRQDDAIVAFQNFVK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 176 AYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELNDSDKAEEAFSTLLKRYPKSQ 255
Cdd:PRK10803  172 KYPDSTYQPNANYWLGQLNYNKGKKDDAAYYFASVVKNYPKSPKAADAMFKVGVIMQDKGDTAKAKAVYQQVIKKYPGTD 251


                  ....*
gi 1084827064 256 AAVKA 260
Cdd:PRK10803  252 GAKQA 256
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 147-260 3.75e-07

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 49.56  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLK 226
Cdd:cd15830     3 AQELYEKAQTALQKGNYDGAIKYLEALDSRYPFGPYAEQAQLDLIYAYYKNADYELALASAERFIRLYPRHPNIDYVYYM 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084827064 227 AGYSYVELNDS-------------D-----KAEEAFSTLLKRYPKSQAAVKA 260
Cdd:cd15830    83 RGLSNYKLDRSflqrffpidrsdrDqsyarEAFQDFKDLIQRYPNSEYATDA 134
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 151-217 4.41e-07

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 46.18  E-value: 4.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084827064 151 YSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDE 217
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
 
Name Accession Description Interval E-value
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 155-260 1.93e-34

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 120.48  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 155 QDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVEL 234
Cdd:COG1729     1 KALLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLEL 80

                          90       100
                  ....*....|....*....|....*.
gi 1084827064 235 NDSDKAEEAFSTLLKRYPKSQAAVKA 260
Cdd:COG1729    81 GDYDKARATLEELIKKYPDSEAAKEA 106
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 149-260 2.82e-34

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 120.08  E-value: 2.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 149 ALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAG 228
Cdd:TIGR02795   2 AYYDAALLVLKAGDYADAIQAFQAFLKKYPKSTYAPNAHYWLGEAYYAQGDYADAAKAFLAVVKKYPKSPKAPDALLKLG 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1084827064 229 YSYVELNDSDKAEEAFSTLLKRYPKSQAAVKA 260
Cdd:TIGR02795  82 MSLQELGDKEKAKATLQQVIKRYPGSSAAKLA 113
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 147-260 6.83e-17

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 78.00  E-value: 6.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLK 226
Cdd:COG4105    32 AEELYEEAKEALEKGDYEKAIKLFEELEPRYPGSPYAEQAQLMLAYAYYKQGDYEEAIAAADRFIKLYPNSPNADYAYYL 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1084827064 227 AGYSYVELNDS--------DKAEEAFSTLLKRYPKSQAAVKA 260
Cdd:COG4105   112 RGLSYYEQSPDsdrdqtstRKAIEAFQELINRYPDSEYAEDA 153
PRK10803 PRK10803
tol-pal system protein YbgF; Provisional
 97-260 8.42e-16

tol-pal system protein YbgF; Provisional


Pssm-ID: 182745 [Multi-domain]  Cd Length: 263  Bit Score: 75.22  E-value: 8.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064  97 TLSGGEGKQPSATPAQPEKAAkkakhDNTVVVSKGQDSEASPELTGD-NEGPDALYSRGQDlfmAGRYDESREVFSRLAS 175
Cdd:PRK10803  100 SLSSGGAAAQSTSGDQSGAAA-----SATPAADAGTANAGAPVQSGDaNTDYNAAIALVQD---KSRQDDAIVAFQNFVK 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 176 AYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELNDSDKAEEAFSTLLKRYPKSQ 255
Cdd:PRK10803  172 KYPDSTYQPNANYWLGQLNYNKGKKDDAAYYFASVVKNYPKSPKAADAMFKVGVIMQDKGDTAKAKAVYQQVIKKYPGTD 251


                  ....*
gi 1084827064 256 AAVKA 260
Cdd:PRK10803  252 GAKQA 256
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 147-223 3.49e-14

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 67.32  E-value: 3.49e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDA 223
Cdd:COG1729    30 PDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 193-267 7.10e-12

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 60.78  E-value: 7.10e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084827064 193 SHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELNDSDKAEEAFSTLLKRYPKSQAAVKAMIGIATI 267
Cdd:COG1729     2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLS 76
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 147-260 2.14e-11

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 62.18  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLK 226
Cdd:TIGR03302  33 AEELYEEAKEALDSGDYTEAIKYFEALESRYPFSPYAEQAQLDLAYAYYKSGDYAEAIAAADRFIRLHPNHPDADYAYYL 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1084827064 227 AGYSYVEL-NDSD-------KAEEAFSTLLKRYPKSQAAVKA 260
Cdd:TIGR03302 113 RGLSNYNQiDRVDrdqtaarEAFEAFQELIRRYPNSEYAPDA 154
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 143-265 8.48e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.90  E-value: 8.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 143 DNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHglaDNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPD 222
Cdd:COG2956    72 DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDD---AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN---AH 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1084827064 223 ALLKAGYSYVELNDSDKAEEAFSTLLKRYPKSQAAVKAMIGIA 265
Cdd:COG2956   146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELY 188
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 93-261 9.51e-11

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 60.66  E-value: 9.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064  93 LAVITLSG---GEGKQPSATPAQPEKAAKKAkhdntvvVSKGQDSEASPELT-------GDNEGPDALYSRGQDLFMAGR 162
Cdd:COG4105    12 LLALLLAGcssFKKALKSWDAEELYEEAKEA-------LEKGDYEKAIKLFEeleprypGSPYAEQAQLMLAYAYYKQGD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 163 YDESREVFSRLASAYPDHGLADNALYWLGESHYSE--------KSFQKALSAFLDITERYPDENKAPDALLK-------- 226
Cdd:COG4105    85 YEEAIAAADRFIKLYPNSPNADYAYYLRGLSYYEQspdsdrdqTSTRKAIEAFQELINRYPDSEYAEDAKKRidelrdkl 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1084827064 227 AGYS------YVELNDSDKAEEAFSTLLKRYPKSQAAVKAM 261
Cdd:COG4105   165 ARKElevaryYLKRGAYVAAINRFQNVLEDYPDTPAVEEAL 205
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 151-264 1.43e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 151 YSRGQDLFMAGRYDESREVFSRLASAYPDHglaDNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLKAGYS 230
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEALELDPET---VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR---AEALLELAQD 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1084827064 231 YVELNDSDKAEEAFSTLLKRYPKSQAAVKAMIGI 264
Cdd:COG2956    86 YLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 147-254 4.01e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 4.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLK 226
Cdd:COG4783    38 PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP---EARLNLGLALLKAGDYDEALALLEKALKLDPEH---PEAYLR 111

                          90       100
                  ....*....|....*....|....*...
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTLLKRYPKS 254
Cdd:COG4783   112 LARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 148-254 4.30e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.66  E-value: 4.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 148 DALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLKA 227
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNP---EAFALLGEILLQLGDLDEAIVLLHEALELDPDE---PEARLNL 78

                          90       100
                  ....*....|....*....|....*..
gi 1084827064 228 GYSYVELNDSDKAEEAFSTLLKRYPKS 254
Cdd:COG4783    79 GLALLKAGDYDEALALLEKALKLDPEH 105
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
147-257 2.39e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.47  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDenkAPDALLK 226
Cdd:COG0457     8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDA---EALYNLGLAYLRLGRYEEALADYEQALELDPD---DAEALNN 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTLLKRYPKSQAA 257
Cdd:COG0457    82 LGLALQALGRYEEALEDYDKALELDPDDAEA 112
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
147-257 3.06e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLK 226
Cdd:COG0457    42 AEALYNLGLAYLRLGRYEEALADYEQALELDPDDA---EALNNLGLALQALGRYEEALEDYDKALELDPDD---AEALYN 115

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTLLKRYPKSQAA 257
Cdd:COG0457   116 LGLALLELGRYDEAIEAYERALELDPDDADA 146
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 147-265 3.15e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLK 226
Cdd:COG4235    17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNA---DALLDLAEALLAAGDTEEAEELLERALALDPDN---PEALYL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTLLKRYPKSQ--AAVKAMIGIA 265
Cdd:COG4235    91 LGLAAFQQGDYAEAIAAWQKLLALLPADApaRLLEASIAEA 131
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 143-254 7.54e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 7.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 143 DNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHglaDNALYWLGESHYSEKSFQKALSAFLDITERYPDenkAPD 222
Cdd:COG2956    38 DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR---AEALLELAQDYLKAGLLDRAEELLEKLLELDPD---DAE 111

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1084827064 223 ALLKAGYSYVELNDSDKAEEAFSTLLKRYPKS 254
Cdd:COG2956   112 ALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 147-260 3.75e-07

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 49.56  E-value: 3.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLK 226
Cdd:cd15830     3 AQELYEKAQTALQKGNYDGAIKYLEALDSRYPFGPYAEQAQLDLIYAYYKNADYELALASAERFIRLYPRHPNIDYVYYM 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084827064 227 AGYSYVELNDS-------------D-----KAEEAFSTLLKRYPKSQAAVKA 260
Cdd:cd15830    83 RGLSNYKLDRSflqrffpidrsdrDqsyarEAFQDFKDLIQRYPNSEYATDA 134
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 151-217 4.41e-07

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 46.18  E-value: 4.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084827064 151 YSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDE 217
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 147-257 8.20e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 8.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLadnALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLK 226
Cdd:COG3914   112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAE---AYLNLGEALRRLGRLEEAIAALRRALELDPDN---AEALNN 185

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTLLKRYPKSQAA 257
Cdd:COG3914   186 LGNALQDLGRLEEAIAAYRRALELDPDNADA 216
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
148-253 1.14e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 48.37  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 148 DALYSRGQDLFMAGRYDESREVFSRLASAYPDhgLADnALYWLGESHYSEKSFQKALSAFLDITERYPDenkAPDALLKA 227
Cdd:COG4785    74 QLYYERGVAYDSLGDYDLAIADFDQALELDPD--LAE-AYNNRGLAYLLLGDYDAALEDFDRALELDPD---YAYAYLNR 147

                          90       100
                  ....*....|....*....|....*.
gi 1084827064 228 GYSYVELNDSDKAEEAFSTLLKRYPK 253
Cdd:COG4785   148 GIALYYLGRYELAIADLEKALELDPN 173
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 143-254 1.43e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 143 DNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDenkAPD 222
Cdd:COG2956   140 GPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA---RALLLLAELYLEQGDYEEAIAALERALEQDPD---YLP 213

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1084827064 223 ALLKAGYSYVELNDSDKAEEAFSTLLKRYPKS 254
Cdd:COG2956   214 ALPRLAELYEKLGDPEEALELLRKALELDPSD 245
TPR_6 pfam13174
Tetratricopeptide repeat;
222-254 2.29e-06

Tetratricopeptide repeat;


Pssm-ID: 463800 [Multi-domain]  Cd Length: 33  Bit Score: 43.23  E-value: 2.29e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1084827064 222 DALLKAGYSYVELNDSDKAEEAFSTLLKRYPKS 254
Cdd:pfam13174   1 DALLKLALAYLELGDTDEAKEALERLIKKYPDS 33
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
143-251 2.40e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.69  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 143 DNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPD 222
Cdd:COG0457    72 DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA---EALYNLGLALLELGRYDEAIEAYERALELDPDD---AD 145

                          90       100
                  ....*....|....*....|....*....
gi 1084827064 223 ALLKAGYSYVELNDSDKAEEAFSTLLKRY 251
Cdd:COG0457   146 ALYNLGIALEKLGRYEEALELLEKLEAAA 174
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 125-271 4.95e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 125 TVVVSKGQDSEASPELTG----DNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHglaDNALYWLGESHYSEKSF 200
Cdd:TIGR02917 235 TILIEAGEFEEAEKHADAllkkAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEY---LPALLLAGASEYQLGNL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 201 QKALSAFLDITERYPDENKA-------------------------------PDALLKAGYSYVELNDSDKAEEAFSTLLK 249
Cdd:TIGR02917 312 EQAYQYLNQILKYAPNSHQArrllasiqlrlgrvdeaiatlspalgldpddPAALSLLGEAYLALGDFEKAAEYLAKATE 391

                         170       180
                  ....*....|....*....|..
gi 1084827064 250 RYPKSqAAVKAMIGIATIISGK 271
Cdd:TIGR02917 392 LDPEN-AAARTQLGISKLSQGD 412
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
157-252 8.06e-06

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 46.03  E-value: 8.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 157 LFMAGRYDESREVF-SRLASAYPDhglaDNALYW-LGESHYSEKSFQKALSAFLDITERYPDeNKAPDALLKAGYSYVEL 234
Cdd:COG4700    99 LLELGRYDEAIELYeEALTGIFAD----DPHILLgLAQALFELGRYAEALETLEKLIAKNPD-FKSSDAHLLYARALEAL 173

                          90
                  ....*....|....*...
gi 1084827064 235 NDSDKAEEAFSTLLKRYP 252
Cdd:COG4700   174 GDLEAAEAELEALARRYS 191
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 176-265 1.75e-05

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 44.85  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 176 AYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELNDSDKAEEAFSTLLKRYPKSQ 255
Cdd:TIGR03302  25 ADPVEEWPAEELYEEAKEALDSGDYTEAIKYFEALESRYPFSPYAEQAQLDLAYAYYKSGDYAEAIAAADRFIRLHPNHP 104

                          90
                  ....*....|..
gi 1084827064 256 AAVKA--MIGIA 265
Cdd:TIGR03302 105 DADYAyyLRGLS 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 149-257 2.04e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 149 ALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNAlywLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLKAG 228
Cdd:COG3914    80 LLELAALLLQALGRYEEALALYRRALALNPDNAEALFN---LGNLLLALGRLEEALAALRRALALNPDF---AEAYLNLG 153

                          90       100
                  ....*....|....*....|....*....
gi 1084827064 229 YSYVELNDSDKAEEAFSTLLKRYPKSQAA 257
Cdd:COG3914   154 EALRRLGRLEEAIAALRRALELDPDNAEA 182
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 148-244 2.29e-05

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 43.05  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 148 DALYSRGQDLFMAGRYDESREVFSRLASAypDHGLADnalYWLG-------ESHYSEKSFQKALSAFLDIterypdenKA 220
Cdd:TIGR02552  18 EQIYALAYNLYQQGRYDEALKLFQLLAAY--DPYNSR---YWLGlaaccqmLKEYEEAIDAYALAAALDP--------DD 84

                          90       100
                  ....*....|....*....|....
gi 1084827064 221 PDALLKAGYSYVELNDSDKAEEAF 244
Cdd:TIGR02552  85 PRPYFHAAECLLALGEPESALKAL 108
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 139-227 3.02e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 139 ELTGDNegPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEn 218
Cdd:COG4235    45 RLDPDN--ADALLDLAEALLAAGDTEEAEELLERALALDPDNP---EALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD- 118


                  ....*....
gi 1084827064 219 kAPDALLKA 227
Cdd:COG4235   119 -APARLLEA 126
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 157-252 5.39e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 5.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 157 LFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLKAGYSYVELND 236
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNP---ELYYNLALLYSRSGDKDEAKEYYEKALALSPDN---PNAYSNLAALLLSLGQ 137

                          90
                  ....*....|....*.
gi 1084827064 237 SDKAEEAFSTLLKRYP 252
Cdd:COG5010   138 DDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
160-257 9.97e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.59  E-value: 9.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 160 AGRYDESREVFSRLASAYPDHGLADNA--LYWLGESHYSEKSFQKALSAFLDITERYPDenkAPDALLKAGYSYVELNDS 237
Cdd:COG4785    47 ALAAAALAAAALAAERIDRALALPDLAqlYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDY 123

                          90       100
                  ....*....|....*....|
gi 1084827064 238 DKAEEAFSTLLKRYPKSQAA 257
Cdd:COG4785   124 DAALEDFDRALELDPDYAYA 143
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 186-257 1.26e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 1.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084827064 186 ALYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLKAGYSYVELNDSDKAEEAFSTLLKRYPKSQAA 257
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALLEKALELDPDN---PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA 74
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 126-217 2.58e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 2.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 126 VVVSKGQDSEASPEL----TGDNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQ 201
Cdd:COG4783    47 ILLQLGDLDEAIVLLhealELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHP---EAYLRLARAYRALGRPD 123

                          90
                  ....*....|....*.
gi 1084827064 202 KALSAFLDITERYPDE 217
Cdd:COG4783   124 EAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 140-251 3.57e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 140 LTGDNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDenk 219
Cdd:COG2956   171 LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYL---PALPRLAELYEKLGDPEEALELLRKALELDPS--- 244

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1084827064 220 aPDALLKAGYSYVELNDSDKAEEAFSTLLKRY 251
Cdd:COG2956   245 -DDLLLALADLLERKEGLEAALALLERQLRRH 275
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 158-260 3.63e-04

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 40.70  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 158 FMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSE------------------KSFQKALSAFLDITERYPDENK 219
Cdd:cd15830    51 YKNADYELALASAERFIRLYPRHPNIDYVYYMRGLSNYKLdrsflqrffpidrsdrdqSYAREAFQDFKDLIQRYPNSEY 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1084827064 220 APDALLK--------AGYsyvELNDSD-----KAEEA----FSTLLKRYPKSQAAVKA 260
Cdd:cd15830   131 ATDAKQRmiylrnrlAEH---ELSIARyylkrGAYIAainrAEEVLENYPDTPATEEA 185
OM_YfiO TIGR03302
outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a ...
 170-252 4.07e-04

outer membrane assembly lipoprotein YfiO; Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274513 [Multi-domain]  Cd Length: 235  Bit Score: 40.61  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 170 FSRLASAYPDHGLADNALYWL--------------GESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELN 235
Cdd:TIGR03302 138 FQELIRRYPNSEYAPDAKKRMdylrnrlagkelyvARFYLKRGAYVAAINRFQTVVENYPDTPATEEALARLVEAYLKLG 217

                          90
                  ....*....|....*..
gi 1084827064 236 DSDKAEEAFSTLLKRYP 252
Cdd:TIGR03302 218 LTDLAQDAAAVLGANYP 234
YfiO pfam13525
Outer membrane lipoprotein; This outer membrane lipoprotein carries a TPR-like region towards ...
 147-260 5.70e-04

Outer membrane lipoprotein; This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.


Pssm-ID: 433282 [Multi-domain]  Cd Length: 200  Bit Score: 40.00  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLK 226
Cdd:pfam13525   4 ASELYEAGQTALQKGDYGDAIKKLEALDNRYPFSPYAEQAQLDLIYAYYKDADYADALAAAERFLRLYPTHPNIDYVYYM 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1084827064 227 AGYSYVELND----SDK-------AEEAFSTLLKRYPKSQAAVKA 260
Cdd:pfam13525  84 RGLSNFAQDRdffrSDRdpesarqAFEDFATLIRKYPDSEYATDA 128
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
157-253 6.01e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 157 LFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALsAFLDITERYPDEnkaPDALLKAGYSYVELND 236
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPDNA---DALNNLGLLLLEQGRYDEAI-ALEKALKLDPNN---AEALLNLAELLLELGD 74

                          90
                  ....*....|....*..
gi 1084827064 237 SDKAEEAFSTLLKRYPK 253
Cdd:COG3063    75 YDEALAYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 147-262 1.17e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLAdnaLYWLGESHYSEKSFQKALSAFLDITERYPDEnkaPDALLK 226
Cdd:TIGR02917 227 IAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLA---HYLKALVDFQKKNYEDARETLQDALKSAPEY---LPALLL 300

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTLLKRYPKSQAAVK--AMI 262
Cdd:TIGR02917 301 AGASEYQLGNLEQAYQYLNQILKYAPNSHQARRllASI 338
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
143-244 3.03e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 143 DNEGPDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPD 222
Cdd:COG0457   106 DPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA---DALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAA 182

                          90       100
                  ....*....|....*....|..
gi 1084827064 223 ALLKAGYSYVELNDSDKAEEAF 244
Cdd:COG0457   183 LGEAALALAAAEVLLALLLALE 204
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 190-254 4.15e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 4.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084827064 190 LGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELNDSDKAEEAFSTLLKRYPKS 254
Cdd:pfam13432   3 LARAALRAGDYDDAAAALEAALARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
TPR_12 pfam13424
Tetratricopeptide repeat;
185-253 4.52e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.44  E-value: 4.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084827064 185 NALYWLGESHYSEKSFQKALSAF---LDITERYPDENKAPDA--LLKAGYSYVELNDSDKAEEAFSTLLKRYPK 253
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLekaLEIARRLLGPDHPLTAttLLNLGRLYLELGRYEEALELLERALALAEK 77
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 159-244 4.63e-03

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 35.31  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 159 MAGRYDESREVFSRLASAYPDHglaDNALYWLGESHYSEKSFQKAlsafLDITERYPDENKAPDALLKAGYSYVELNDSD 238
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAAEPES---PEDAYLLAQCLFLNGQYKRA----YELLRKAKLNGSSLGCRYLFAQCLLKLKKYD 73


                  ....*.
gi 1084827064 239 KAEEAF 244
Cdd:pfam12895  74 EALDAL 79
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 147-192 5.32e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 35.74  E-value: 5.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGLADNALYWLGE 192
Cdd:COG1729    67 PDALLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEARARLAR 112
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 147-179 8.46e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 33.27  E-value: 8.46e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPD 179
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 147-247 9.49e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 37.28  E-value: 9.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 147 PDALYSRGQDLFMAGRYDESREVFSRLASAYPDHGladNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLK 226
Cdd:COG3914   146 AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA---EALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLF 222

                          90       100
                  ....*....|....*....|.
gi 1084827064 227 AGYSYVELNDSDKAEEAFSTL 247
Cdd:COG3914   223 ALRQACDWEVYDRFEELLAAL 243
YfiO pfam13525
Outer membrane lipoprotein; This outer membrane lipoprotein carries a TPR-like region towards ...
 184-265 9.98e-03

Outer membrane lipoprotein; This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.


Pssm-ID: 433282 [Multi-domain]  Cd Length: 200  Bit Score: 36.15  E-value: 9.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084827064 184 DNALYWLGESHYSEKSFQKALSAFLDITERYPDENKAPDALLKAGYSYVELNDSDKAEEAFSTLLKRYP--KSQAAVKAM 261
Cdd:pfam13525   4 ASELYEAGQTALQKGDYGDAIKKLEALDNRYPFSPYAEQAQLDLIYAYYKDADYADALAAAERFLRLYPthPNIDYVYYM 83


                  ....
gi 1084827064 262 IGIA 265
Cdd:pfam13525  84 RGLS 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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