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Conserved domains on  [gi|1084961499|gb|OGR76083|]
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hypothetical protein A2X40_06345 [Elusimicrobia bacterium GWC2_65_9]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 11445445)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
21-228 4.11e-29

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


:

Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 109.34  E-value: 4.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  21 YHRPAGpqGRRFPAVLFLHGFPGAEKS--VDVQRELMARGVASVAPHFLGSWGSGGTYRfTTLVPQARAALRAMRKLPFV 98
Cdd:COG1506    14 LYLPAD--GKKYPVVVYVHGGPGSRDDsfLPLAQALASRGYAVLAPDYRGYGESAGDWG-GDEVDDVLAAIDYLAARPYV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  99 DPRRVAVFGFSMGGWAALNLAAAD-GTLKAAVAVAPAGGPEMIGPGTRDFLARLcaplnapkpAALLADFRRAVTAGDPA 177
Cdd:COG1506    91 DPDRIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDLRSYYGTTREYTERL---------MGGPWEDPEAYAARSPL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1084961499 178 KAVRRLRMPLLLVHGDADEIIPAAVSRRL---LDLAEGPAQLVVEHGADHGLLD 228
Cdd:COG1506   162 AYADKLKTPLLLIHGEADDRVPPEQAERLyeaLKKAGKPVELLVYPGEGHGFSG 215
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
21-228 4.11e-29

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 109.34  E-value: 4.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  21 YHRPAGpqGRRFPAVLFLHGFPGAEKS--VDVQRELMARGVASVAPHFLGSWGSGGTYRfTTLVPQARAALRAMRKLPFV 98
Cdd:COG1506    14 LYLPAD--GKKYPVVVYVHGGPGSRDDsfLPLAQALASRGYAVLAPDYRGYGESAGDWG-GDEVDDVLAAIDYLAARPYV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  99 DPRRVAVFGFSMGGWAALNLAAAD-GTLKAAVAVAPAGGPEMIGPGTRDFLARLcaplnapkpAALLADFRRAVTAGDPA 177
Cdd:COG1506    91 DPDRIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDLRSYYGTTREYTERL---------MGGPWEDPEAYAARSPL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1084961499 178 KAVRRLRMPLLLVHGDADEIIPAAVSRRL---LDLAEGPAQLVVEHGADHGLLD 228
Cdd:COG1506   162 AYADKLKTPLLLIHGEADDRVPPEQAERLyeaLKKAGKPVELLVYPGEGHGFSG 215
PRK10566 PRK10566
esterase; Provisional
 83-226 2.04e-07

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 50.37  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  83 PQARAALRAmRKLpfVDPRRVAVFGFSMGGWAALNLAAADGTLKAAVAvapaggpeMIGPGTRDFLAR-LCAPLNAPKPA 161
Cdd:PRK10566   92 PTLRAAIRE-EGW--LLDDRLAVGGASMGGMTALGIMARHPWVKCVAS--------LMGSGYFTSLARtLFPPLIPETAA 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084961499 162 ALlADFRRAVTAGDPAKAVRRL----RMPLLLVHGDADEIIPAAVSRRLldlaegpAQLVVEHGADHGL 226
Cdd:PRK10566  161 QQ-AEFNNIVAPLAEWEVTHQLeqlaDRPLLLWHGLADDVVPAAESLRL-------QQALRERGLDKNL 221
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
54-225 3.49e-07

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 49.54  E-value: 3.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  54 LMARGVASVAPHFLGSWGSGGTYRF-------TTLVPQARAALRAMRKLPFVDPRRVAVFGFSMGGWAAlNLAAADGTLK 126
Cdd:pfam00326  10 LADRGYVVAIANGRGSGGYGEAFHDagkgdlgQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLT-GAALNQRPDL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 127 AAVAVAPAGGPEMIG-------PGTRDFLARLCAPLNApkpaallaDFRRAVTAGDPAKAVRRLRmPLLLVHGDADEIIP 199
Cdd:pfam00326  89 FKAAVAHVPVVDWLAymsdtslPFTERYMEWGNPWDNE--------EGYDYLSPYSPADNVKVYP-PLLLIHGLLDDRVP 159

                         170       180
                  ....*....|....*....|....*....
gi 1084961499 200 AAVSRRL---LDLAEGPAQLVVEHGADHG 225
Cdd:pfam00326 160 PWQSLKLvaaLQRKGVPFLLLIFPDEGHG 188
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
21-228 4.11e-29

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 109.34  E-value: 4.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  21 YHRPAGpqGRRFPAVLFLHGFPGAEKS--VDVQRELMARGVASVAPHFLGSWGSGGTYRfTTLVPQARAALRAMRKLPFV 98
Cdd:COG1506    14 LYLPAD--GKKYPVVVYVHGGPGSRDDsfLPLAQALASRGYAVLAPDYRGYGESAGDWG-GDEVDDVLAAIDYLAARPYV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  99 DPRRVAVFGFSMGGWAALNLAAAD-GTLKAAVAVAPAGGPEMIGPGTRDFLARLcaplnapkpAALLADFRRAVTAGDPA 177
Cdd:COG1506    91 DPDRIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDLRSYYGTTREYTERL---------MGGPWEDPEAYAARSPL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1084961499 178 KAVRRLRMPLLLVHGDADEIIPAAVSRRL---LDLAEGPAQLVVEHGADHGLLD 228
Cdd:COG1506   162 AYADKLKTPLLLIHGEADDRVPPEQAERLyeaLKKAGKPVELLVYPGEGHGFSG 215
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 14-224 9.95e-28

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 106.15  E-value: 9.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  14 GRKMLAPYHRPAGPQGRRfPAVLFLHGFPG-AEKSVDVQRELMARGVASVAPHFLGSWGSGGTYRFTTLVPQ--ARAALR 90
Cdd:COG1073    20 GIKLAGDLYLPAGASKKY-PAVVVAHGNGGvKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEGSPERrdARAAVD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  91 AMRKLPFVDPRRVAVFGFSMGGWAALNLAAADGTLKA---------AVAVAPAGGPEMIGPGTrdflarlcaPLNAPKPA 161
Cdd:COG1073    99 YLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAvildspftsLEDLAAQRAKEARGAYL---------PGVPYLPN 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084961499 162 ALLADFRRAvtAGDPAKAVRRLRMPLLLVHGDADEIIPAAVSRRLLDLAEGPAQLVVEHGADH 224
Cdd:COG1073   170 VRLASLLND--EFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGH 230
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
26-227 1.51e-18

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 81.20  E-value: 1.51e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  26 GPQGRRFPAVLFLHGF-PGAEKSVDVQRELMARGVASVAPHFLG---SWGSGGTY-RFTTLVPQARAALRAMRKLPfvdP 100
Cdd:COG2267    22 RPAGSPRGTVVLVHGLgEHSGRYAELAEALAAAGYAVLAFDLRGhgrSDGPRGHVdSFDDYVDDLRAALDALRARP---G 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 101 RRVAVFGFSMGGWAALNLAAADGtlkaavavapaggpemigpgtrDFLAR--LCAPLNAPKPaaLLADFRRAVTAGDPAK 178
Cdd:COG2267    99 LPVVLLGHSMGGLIALLYAARYP----------------------DRVAGlvLLAPAYRADP--LLGPSARWLRALRLAE 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1084961499 179 AVRRLRMPLLLVHGDADEIIPAAVSRRLLDLAEGPAQLVVEHGADHGLL 227
Cdd:COG2267   155 ALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHELL 203
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 21-226 3.36e-18

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 80.05  E-value: 3.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  21 YHRPAGPQGrrfPAVLFLHGFPGAEKSVDVQRELMARGVASVAPHFLGSWGSGGTYRFTTLVPQARAALRAMRKLpfvDP 100
Cdd:COG0596    15 HYREAGPDG---PPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDAL---GL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 101 RRVAVFGFSMGGWAALNLAAADG------TLkaavavapaggpemIGPGTRDFLARLCAPLNAPKPaalLADFRRAVTAG 174
Cdd:COG0596    89 ERVVLVGHSMGGMVALELAARHPervaglVL--------------VDEVLAALAEPLRRPGLAPEA---LAALLRALART 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084961499 175 DPAKAVRRLRMPLLLVHGDADEIIPAAVSRRLLDLAEGpAQLVVEHGADHGL 226
Cdd:COG0596   152 DLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPN-AELVVLPGAGHFP 202
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
7-225 1.75e-17

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 78.47  E-value: 1.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499   7 IEIFRVLGRKMLAPYHRPAGpqGRRFPAVLFLHGFPG-AEKSVDVQRELMARGVASVAPHFLGSWGSG----------GT 75
Cdd:COG0412     6 VTIPTPDGVTLPGYLARPAG--GGPRPGVVVLHEIFGlNPHIRDVARRLAAAGYVVLAPDLYGRGGPGddpdearalmGA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  76 YRFTTLVPQARAALRAMRKLPFVDPRRVAVFGFSMGGWAALNLAAADGTLKAavavapaggpemigpgtrdflarlCAPL 155
Cdd:COG0412    84 LDPELLAADLRAALDWLKAQPEVDAGRVGVVGFCFGGGLALLAAARGPDLAA------------------------AVSF 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084961499 156 NAPKPAALLADfrravtagdpakAVRRLRMPLLLVHGDADEIIPAAVSRRL---LDLAEGPAQLVVEHGADHG 225
Cdd:COG0412   140 YGGLPADDLLD------------LAARIKAPVLLLYGEKDPLVPPEQVAALeaaLAAAGVDVELHVYPGAGHG 200
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
24-224 6.59e-14

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 69.75  E-value: 6.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  24 PAGPQGRRFPAVLFLHGFPGAEKS-VDVQRELMARGVASVAPHFLGS----WGSGGTYRFTTLVPQA--------RAALR 90
Cdd:COG4188    54 ADAPAGGPFPLVVLSHGLGGSREGyAYLAEHLASHGYVVAAPDHPGSnaadLSAALDGLADALDPEElwerpldlSFVLD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  91 AMRKL--------PFVDPRRVAVFGFSMGGWAALNLAAADGTLKAAVAVAPAGGpemigpgtrdflARLCAPLNAPKPAA 162
Cdd:COG4188   134 QLLALnksdpplaGRLDLDRIGVIGHSLGGYTALALAGARLDFAALRQYCGKNP------------DLQCRALDLPRLAY 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084961499 163 LLADFR-RAVTAGDP-------AKAVRRLRMPLLLVHGDADEIIPAAVSRRLL--DLAEGPAQLVVEHGADH 224
Cdd:COG4188   202 DLRDPRiKAVVALAPggsglfgEEGLAAITIPVLLVAGSADDVTPAPDEQIRPfdLLPGADKYLLTLEGATH 273
COG4099 COG4099
Predicted peptidase [General function prediction only];
29-225 5.80e-13

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 66.14  E-value: 5.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  29 GRRFPAVLFLHGfpGAEKSVDVQRELMARgvasvAPHFLGSWgSGGTYRFTTLVPQAR---------------AALRAMR 93
Cdd:COG4099    46 GKKYPLVLFLHG--AGERGTDNEKQLTHG-----APKFINPE-NQAKFPAIVLAPQCPeddywsdtkaldavlALLDDLI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  94 KLPFVDPRRVAVFGFSMGGWAALNLAAADgtlkaavavapaggpemigPGTrdFlarlcaplnapkpAALLAdfrrAVTA 173
Cdd:COG4099   118 AEYRIDPDRIYLTGLSMGGYGTWDLAARY-------------------PDL--F-------------AAAVP----ICGG 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1084961499 174 GDPAKAVRRLRMPLLLVHGDADEIIPAAVSRRLLD--LAEGP-AQLVVEHGADHG 225
Cdd:COG4099   160 GDPANAANLKKVPVWIFHGAKDDVVPVEESRAMVEalKAAGAdVKYTEYPGVGHN 214
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
17-224 1.55e-12

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 64.96  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  17 MLAPYHRPAGPQGRRfPAVLFLHGFPGAEKSV-DVQRELMARGVASVAPHFLG---SWGSGGTYRFTTLVPQARAALRAM 92
Cdd:COG1647     1 MKILGAEPFFLEGGR-KGVLLLHGFTGSPAEMrPLAEALAKAGYTVYAPRLPGhgtSPEDLLKTTWEDWLEDVEEAYEIL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  93 RKLPfvdpRRVAVFGFSMGGWAALNLAAADGTLK---------------AAVAVAPAGGPEMIGPGTRDFLARLCAPLNA 157
Cdd:COG1647    80 KAGY----DKVIVIGLSMGGLLALLLAARYPDVAglvllspalkiddpsAPLLPLLKYLARSLRGIGSDIEDPEVAEYAY 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084961499 158 PK-PAALLADFRRAVTAGdpAKAVRRLRMPLLLVHGDADEIIPAAVSRRLLDLAEGPA-QLVVEHGADH 224
Cdd:COG1647   156 DRtPLRALAELQRLIREV--RRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDkELVWLEDSGH 222
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
23-120 2.30e-10

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 59.08  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  23 RPAGPQGRRFPAVLFLHGFPGAEKSV----DVQRELMARGVASVAP-HFLGSW------GSGGTYRFTT-----LVPQAR 86
Cdd:COG0627    24 LPPGYDGRPLPVLYLLHGLTGTHENWtrktGAQRLAAELGVIVVMPdGGQASFyvdwtqGPAGHYRWETylteeLPPLIE 103

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1084961499  87 AALRAMRklpfvDPRRVAVFGFSMGGWAALNLAA 120
Cdd:COG0627   104 ANFPVSA-----DRERRAIAGLSMGGHGALTLAL 132
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
21-224 1.35e-08

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 53.24  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  21 YHRPAGPqgrRFPAVLFLHGFPGAEKSVD------VQRELMARGVASVAPHFLGSWGSGGTY------RFttlvpQARAA 88
Cdd:COG2945    15 LDLPEGP---PRGVALILHPHPLFGGTMDnkvvytLARALVAAGFAVLRFNFRGVGRSEGEFdegrgeLD-----DAAAA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  89 LRAMRKLPfvdPRRVAVFGFSMGGWAALNLAAADgtlkaavavapaggpemigPGTRDFLARlcaplnapKPAALLADFR 168
Cdd:COG2945    87 LDWLRAQN---PLPLWLAGFSFGAYVALQLAMRL-------------------PEVEGLILV--------APPVNRYDFS 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1084961499 169 ravtagdpakAVRRLRMPLLLVHGDADEIIPAAVSRRLLDLAEGPAQLVVEHGADH 224
Cdd:COG2945   137 ----------FLAPCPAPTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH 182
PRK10566 PRK10566
esterase; Provisional
 83-226 2.04e-07

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 50.37  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  83 PQARAALRAmRKLpfVDPRRVAVFGFSMGGWAALNLAAADGTLKAAVAvapaggpeMIGPGTRDFLAR-LCAPLNAPKPA 161
Cdd:PRK10566   92 PTLRAAIRE-EGW--LLDDRLAVGGASMGGMTALGIMARHPWVKCVAS--------LMGSGYFTSLARtLFPPLIPETAA 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084961499 162 ALlADFRRAVTAGDPAKAVRRL----RMPLLLVHGDADEIIPAAVSRRLldlaegpAQLVVEHGADHGL 226
Cdd:PRK10566  161 QQ-AEFNNIVAPLAEWEVTHQLeqlaDRPLLLWHGLADDVVPAAESLRL-------QQALRERGLDKNL 221
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
54-225 3.49e-07

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 49.54  E-value: 3.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  54 LMARGVASVAPHFLGSWGSGGTYRF-------TTLVPQARAALRAMRKLPFVDPRRVAVFGFSMGGWAAlNLAAADGTLK 126
Cdd:pfam00326  10 LADRGYVVAIANGRGSGGYGEAFHDagkgdlgQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLT-GAALNQRPDL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 127 AAVAVAPAGGPEMIG-------PGTRDFLARLCAPLNApkpaallaDFRRAVTAGDPAKAVRRLRmPLLLVHGDADEIIP 199
Cdd:pfam00326  89 FKAAVAHVPVVDWLAymsdtslPFTERYMEWGNPWDNE--------EGYDYLSPYSPADNVKVYP-PLLLIHGLLDDRVP 159

                         170       180
                  ....*....|....*....|....*....
gi 1084961499 200 AAVSRRL---LDLAEGPAQLVVEHGADHG 225
Cdd:pfam00326 160 PWQSLKLvaaLQRKGVPFLLLIFPDEGHG 188
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
23-225 4.46e-06

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 46.02  E-value: 4.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  23 RPAGPQGRRfPAVLFLHG----FPGAEKSVDVQRELMA-RGVASVAPHFlgswGSGGTYRFTTLVPQARAALRAMRKLPF 97
Cdd:COG0657     5 RPAGAKGPL-PVVVYFHGggwvSGSKDTHDPLARRLAArAGAAVVSVDY----RLAPEHPFPAALEDAYAALRWLRANAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  98 ---VDPRRVAVFGFSMGGwaalNLAAAdgtlkaavavapaggpemigpgtrdfLARLCAPLNAPKPAALLA-----DFRR 169
Cdd:COG0657    80 elgIDPDRIAVAGDSAGG----HLAAA--------------------------LALRARDRGGPRPAAQVLiypvlDLTA 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1084961499 170 AVTAGDPAKAVrrlrmPLLLVHGDADEIIPAAVS-RRLLDLAEGPAQLVVEHGADHG 225
Cdd:COG0657   130 SPLRADLAGLP-----PTLIVTGEADPLVDESEAlAAALRAAGVPVELHVYPGGGHG 181
DLH pfam01738
Dienelactone hydrolase family;
25-227 5.74e-06

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 45.81  E-value: 5.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  25 AGPQGRRFPAVLFLHGFPGAEKSV-DVQRELMARGVASVAPHFLGSWGSGGTY--RFTTL------------VPQARAAL 89
Cdd:pfam01738   5 ATPKNPPWPVVVVFQEIFGVNDNIrEIADRLADEGYVALAPDLYFRQGDPNDEadAARAMfelvskrvmekvLDDLEAAV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  90 RAMRKLPFVDPRRVAVFGFSMGGWAALNLAAADGTLKAavavapaggpemigpgtrdflarlCAPLNAPKPAALLADfrr 169
Cdd:pfam01738  85 NYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDA------------------------AVGFYGVGPEPPLIE--- 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084961499 170 avtagdpakaVRRLRMPLLLVHGDADEIIPAAVSRRL---LDLAEGPAQLVVEHGADHGLL 227
Cdd:pfam01738 138 ----------APDIKAPILFHFGEEDHFVPADSRELIeeaLKAANVDHQIHSYPGAGHAFA 188
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 21-121 2.77e-05

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 44.41  E-value: 2.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  21 YHRPAGpqGRRFPAVLFLHGFPGAEKSVDVQRELMARGVASVAPHFLG---SWG--------SGG--------------T 75
Cdd:COG3458    73 LLRPKG--EGPLPAVVEFHGYGGGRGLPHEDLDWAAAGYAVLVMDTRGqgsSWGdtpdpggySGGalpgymtrgiddpdT 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1084961499  76 YRFTTLVPQARAALRAMRKLPFVDPRRVAVFGFSMGGwaALNLAAA 121
Cdd:COG3458   151 YYYRRVYLDAVRAVDALRSLPEVDGKRIGVTGGSQGG--GLALAAA 194
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
22-119 2.98e-05

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 44.46  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  22 HRPAG--PQGRRFPAVLFLHGFPGAE----KSVDVQR---ELMARGVAsVAPHFLGSWGSGGTYRFTTLvPQARAALRAM 92
Cdd:COG2382   100 YLPPGydNPGKKYPVLYLLDGGGGDEqdwfDQGRLPTildNLIAAGKI-PPMIVVMPDGGDGGDRGTEG-PGNDAFERFL 177

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1084961499  93 RK--LPFV--------DPRRVAVFGFSMGGWAALNLA 119
Cdd:COG2382   178 AEelIPFVeknyrvsaDPEHRAIAGLSMGGLAALYAA 214
YpfH COG0400
Predicted esterase [General function prediction only];
33-226 1.16e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.82  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  33 PAVLFLHGFPGAEKS-VDVQRELMARGVASVAPHFLGSWGSGGtYRFTTL--------VPQARAALRAMRKL-------P 96
Cdd:COG0400     6 PLVVLLHGYGGDEEDlLPLAPELALPGAAVLAPRAPVPEGPGG-RAWFDLsflegredEEGLAAAAEALAAFidelearY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  97 FVDPRRVAVFGFSMGGWAALNLAAADGTLkaavavapaggpemigpgtrdfLARLCApLNAPKPAALLADFRRAVTAGdp 176
Cdd:COG0400    85 GIDPERIVLAGFSQGAAMALSLALRRPEL----------------------LAGVVA-LSGYLPGEEALPAPEAALAG-- 139

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084961499 177 akavrrlrMPLLLVHGDADEIIPAAVSRRLLD-LAEGPAQL-VVEHGADHGL 226
Cdd:COG0400   140 --------TPVFLAHGTQDPVIPVERAREAAEaLEAAGADVtYREYPGGHEI 183
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 33-228 1.48e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 41.72  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  33 PAVLFLHGFPGaekSVDVQRELM---ARGVASV-APHFLG---SWGSGGTYRFTTLVpQARAALRAMRKLPFvdpRRVAV 105
Cdd:pfam00561   1 PPVLLLHGLPG---SSDLWRKLApalARDGFRViALDLRGfgkSSRPKAQDDYRTDD-LAEDLEYILEALGL---EKVNL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 106 FGFSMGGWAALNLAAA-----------DGTLKAAVAVAPAGGPEMIGPGTRDFLARLCAPLN-APKPAALLA--DFRRAV 171
Cdd:pfam00561  74 VGHSMGGLIALAYAAKypdrvkalvllGALDPPHELDEADRFILALFPGFFDGFVADFAPNPlGRLVAKLLAllLLRLRL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 172 TAGDPAKAVRRLRM---------------------------------PLLLVHGDADEIIPAAVSRRLLDLAEGPAQLVV 218
Cdd:pfam00561 154 LKALPLLNKRFPSGdyalakslvtgallfietwstelrakflgrldePTLIIWGDQDPLVPPQALEKLAQLFPNARLVVI 233

                         250
                  ....*....|
gi 1084961499 219 EHGADHGLLD 228
Cdd:pfam00561 234 PDAGHFAFLE 243
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 34-227 1.08e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 39.12  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  34 AVLFLHGFpgAEKS---VDVQRELMARGVASVAPHFLGSWGSGGTY----RFTTLVPQARAALRAMRKLPFVDPRrvAVF 106
Cdd:pfam12146   6 VVVLVHGL--GEHSgryAHLADALAAQGFAVYAYDHRGHGRSDGKRghvpSFDDYVDDLDTFVDKIREEHPGLPL--FLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499 107 GFSMGG-------------WAALNLAAA--DGTLKAAVAVAPAGGPEM--IGPG------------TRD--FLARLCA-P 154
Cdd:pfam12146  82 GHSMGGliaalyalrypdkVDGLILSAPalKIKPYLAPPILKLLAKLLgkLFPRlrvpnnllpdslSRDpeVVAAYAAdP 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084961499 155 LNAPKPAA--LLADFRRAVTAGDPAKavrRLRMPLLLVHGDADEIIPAAVSRRLLD-LAEGPAQLVVEHGADHGLL 227
Cdd:pfam12146 162 LVHGGISArtLYELLDAGERLLRRAA---AITVPLLLLHGGADRVVDPAGSREFYErAGSTDKTLKLYPGLYHELL 234
frsA PRK05077
esterase FrsA;
87-119 1.85e-03

esterase FrsA;


Pssm-ID: 235337  Cd Length: 414  Bit Score: 39.12  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1084961499  87 AALRAMRKLPFVDPRRVAVFGFSMGGWAALNLA 119
Cdd:PRK05077  251 AVLNALPNVPWVDHTRVAAFGFRFGANVAVRLA 283
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 13-120 6.19e-03

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 37.06  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084961499  13 LGRKMLAPYHRPAG-PQGRRFPAVLFLHG---------FPGAEKSVDvqRELMARGVASVAP-----HFLGSWGSGgtyR 77
Cdd:pfam00756   4 LGREMKVQVYLPEDyPPGRKYPVLYLLDGtgwfqngpaKEGLDRLAA--SGEIPPVIIVGSPrggevSFYSDWDRG---L 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1084961499  78 FTTLVPQARAALRAMRK--LPFVD------PRRVAVFGFSMGGWAALNLAA 120
Cdd:pfam00756  79 NATEGPGAYAYETFLTQelPPLLDanfptaPDGRALAGQSMGGLGALYLAL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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