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Conserved domains on  [gi|1085344793|gb|OGV17480|]
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MAG: hypothetical protein A2237_07470 [Stygiobacter sp. RIFOXYA2_FULL_38_8]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 1-139 2.93e-29

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 109.16  E-value: 2.93e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGN-GEIENSLREMvkQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEV 79
Cdd:cd03801   228 IVGGdGPLRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEV 305

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  80 IKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELY 139
Cdd:cd03801   306 VEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 1-139 2.93e-29

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 109.16  E-value: 2.93e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGN-GEIENSLREMvkQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEV 79
Cdd:cd03801   228 IVGGdGPLRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEV 305

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  80 IKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELY 139
Cdd:cd03801   306 VEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 1-120 4.48e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 93.49  E-value: 4.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:pfam00534  38 IAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVV 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1085344793  81 KDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKK 120
Cdd:pfam00534 118 KDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENARK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 38-144 6.35e-24

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 89.66  E-value: 6.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  38 AIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRI 117
Cdd:COG0438    17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGEA 96

                          90       100
                  ....*....|....*....|....*..
gi 1085344793 118 GKKNLSDEFSTQKMVNQIHELYTSLLQ 144
Cdd:COG0438    97 ARERAEERFSWEAIAERLLALYEELLA 123
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
1-142 3.49e-13

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 65.12  E-value: 3.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLI-QP-EEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFD-LDGAH 77
Cdd:PRK09922  215 IIGDGSDFEKCKAYSRELGIEQRIIWHGWQsQPwEVVQQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCISSDcMSGPR 294

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1085344793  78 EVIKDGVNGYLIEPENdamlsdrILDLATNLEKAKEfgriGKKnlsdEFSTQKMVNQIHELYTSL 142
Cdd:PRK09922  295 DIIKPGLNGELYTPGN-------IDEFVGKLNKVIS----GEV----KYQHDAIPNSIERFYEVL 344
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 1-139 2.93e-29

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 109.16  E-value: 2.93e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGN-GEIENSLREMvkQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEV 79
Cdd:cd03801   228 IVGGdGPLRAELEEL--ELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEV 305

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  80 IKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELY 139
Cdd:cd03801   306 VEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 1-135 1.08e-27

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 104.98  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGliQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd03808   225 LVGDGELENPSEILIEKLGLEGRIEFLG--FRSDVPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELV 302

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1085344793  81 KDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQI 135
Cdd:cd03808   303 IDGVNGFLVPPGDVEALADAIEKLIEDPELRKEMGEAARKRVEEKFDEEKVVNKL 357
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 1-120 4.48e-25

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 93.49  E-value: 4.48e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:pfam00534  38 IAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVV 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1085344793  81 KDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKK 120
Cdd:pfam00534 118 KDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENARK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 38-144 6.35e-24

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 89.66  E-value: 6.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  38 AIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRI 117
Cdd:COG0438    17 LLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGEA 96

                          90       100
                  ....*....|....*....|....*..
gi 1085344793 118 GKKNLSDEFSTQKMVNQIHELYTSLLQ 144
Cdd:COG0438    97 ARERAEERFSWEAIAERLLALYEELLA 123
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 2-134 3.60e-22

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 89.99  E-value: 3.60e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   2 IGNGEIENSLREMVKQMNLTDRVIFTGLIQP--EEIPSAiavvDILVHTSLLEGLARVLPQAIMMEKPVISFDLD-GAHE 78
Cdd:cd03820   218 YGDGPEREELEKLIDKLGLEDRVKLLGPTKNiaEEYANS----SIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPtGPSE 293

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1085344793  79 VIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNlSDEFSTQKMVNQ 134
Cdd:cd03820   294 IIEDGENGLLVPNGDVDALAEALLRLMEDEELRKKMGKNARKN-AERFSIEKIIKQ 348
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
1-107 1.44e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 84.10  E-value: 1.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIEnSLREMVKqmNLTDRVIFTGLIqpEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:pfam13692  38 IVGDGPEE-ELEELAA--GLEDRVIFTGFV--EDLAELLAAADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELV 112

                          90       100
                  ....*....|....*....|....*..
gi 1085344793  81 kDGVNGYLIEPENDAMLSDRILDLATN 107
Cdd:pfam13692 113 -DGENGLLVPPGDPEALAEAILRLLED 138
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 1-118 4.84e-21

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 87.03  E-value: 4.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIqpEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd03819   217 VAGDGPERDEIRRLVERLGLRDRVTFTGFR--EDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIV 294

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1085344793  81 KDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIG 118
Cdd:cd03819   295 VHGRTGLLVPPGDAEALADAIRAAKLLPEAREKLQAAA 332
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 1-139 4.53e-20

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 84.35  E-value: 4.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd03798   236 IVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVV 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1085344793  81 KDGVNGYLIEPENDAMLSDRILDLAtNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELY 139
Cdd:cd03798   316 GDPETGLLVPPGDADALAAALRRAL-AEPYLRELGEAARARVAERFSWVKAADRIAAAY 373
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 1-135 5.44e-20

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 84.25  E-value: 5.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd03817   236 IVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELV 315

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1085344793  81 KDGVNGYLIEPEND--AMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQI 135
Cdd:cd03817   316 EDGENGFLFEPNDEtlAEKLLHLRENLELLRKLSKNAEISAREFAFAKSVEKLYEEV 372
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 2-140 1.79e-18

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 80.05  E-value: 1.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   2 IGNGEIENSLREMVKQMNLTDRVIFTGLIQpeEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIK 81
Cdd:cd03807   227 VGRGPERPNLERLLLELGLEDRVHLLGERS--DVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVD 304

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1085344793  82 DGVnGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELYT 140
Cdd:cd03807   305 DGT-GFLVPAGDPQALADAIRALLEDPEKRARLGRAARERIANEFSIDAMVRRYETLYY 362
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 2-116 2.12e-18

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 79.71  E-value: 2.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   2 IGNGEIENSLREMVKQMNLTDRVIFTGLIQPeeIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIK 81
Cdd:cd03811   225 LGDGPLREELEKLAKELGLAERVIFLGFQSN--PYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILD 302

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1085344793  82 DGVNGYLIEPENDAMLS---DRILDLATNLEKAKEFGR 116
Cdd:cd03811   303 DGENGLLVPDGDAAALAgilAALLQKKLDAALRERLAK 340
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 1-135 5.39e-16

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 72.87  E-value: 5.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSL------LEGLARVLPQAIMMEKPVISFDLD 74
Cdd:cd03799   210 IIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVtaadgdQDGPPNTLKEAMAMGLPVISTEHG 289

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1085344793  75 GAHEVIKDGVNGYLIePENDA-MLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQI 135
Cdd:cd03799   290 GIPELVEDGVSGFLV-PERDAeAIAEKLTYLIEHPAIWPEMGKAGRARVEEEYDINKLNDEL 350
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 2-135 2.61e-14

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 68.52  E-value: 2.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   2 IGNGEIENSLREMVKQMNLtDRVIFTGLIQPEEIPSAIAVVDI-LVHTSLLEGLARVLP----QAIMMEKPVISFDLDGA 76
Cdd:cd03794   253 VGDGDEKERLKELAKARGL-DNVTFLGRVPKEEVPELLSAADVgLVPLKDNPANRGSSPsklfEYMAAGKPILASDDGGS 331

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1085344793  77 HEVIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQI 135
Cdd:cd03794   332 DLAVEINGCGLVVEPGDPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLADRL 390
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 1-132 3.54e-14

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 68.07  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKqMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLL--EGLARVLPQAIMMEKPVISFDLD-GAH 77
Cdd:cd03795   222 IGGEGPLKPDLEAQIE-LNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVLrsEAFGIVLLEAMMCGKPVISTNIGtGVP 300

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1085344793  78 EVIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMV 132
Cdd:cd03795   301 YVNNNGETGLVVPPKDPDALAEAIDKLLSDEELRESYGENAKKRFEELFTAEKMK 355
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 1-134 4.15e-14

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 67.71  E-value: 4.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLI-QPEEIpsaIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLD-GAHE 78
Cdd:cd04949   196 IYGYGEEREKLKKLIEELHLEDNVFLKGYHsNLDQE---YQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVKyGPSE 272

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1085344793  79 VIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRiGKKNLSDEFSTQKMVNQ 134
Cdd:cd04949   273 LIEDGENGYLIEKNNIDALADKIIELLNDPEKLQQFSE-ESYKIAEKYSTENVMEK 327
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
1-142 3.49e-13

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 65.12  E-value: 3.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLI-QP-EEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFD-LDGAH 77
Cdd:PRK09922  215 IIGDGSDFEKCKAYSRELGIEQRIIWHGWQsQPwEVVQQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCISSDcMSGPR 294

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1085344793  78 EVIKDGVNGYLIEPENdamlsdrILDLATNLEKAKEfgriGKKnlsdEFSTQKMVNQIHELYTSL 142
Cdd:PRK09922  295 DIIKPGLNGELYTPGN-------IDEFVGKLNKVIS----GEV----KYQHDAIPNSIERFYEVL 344
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 12-139 1.07e-12

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 63.89  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  12 REMVKQMNLTDRVIFTGLIQPEEIpsaIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGVN-----G 86
Cdd:cd03813   344 KRLVASLGLENKVKFLGFQNIKEY---YPKLGLLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIYGADDalgqaG 420

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1085344793  87 YLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELY 139
Cdd:cd03813   421 LVVPPADPEALAEALIKLLRDPELRQAFGEAGRKRVEKYYTLEGMIDSYRKLY 473
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 1-139 1.88e-12

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 63.14  E-value: 1.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGliQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd04962   231 LVGDGPERVPAEELARELGVEDRVLFLG--KQDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVV 308

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  81 KDGVNGYLIEPEN-DAMlSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELY 139
Cdd:cd04962   309 KHGETGFLSDVGDvDAM-AKSALSILEDDELYNRMGRAARKRAAERFDPERIVPQYEAYY 367
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 1-141 9.40e-12

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 61.31  E-value: 9.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLIqpEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd04951   224 IAGDGPLRNELERLICNLNLVDRVILLGQI--SNISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVV 301

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1085344793  81 KDgvNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIHELYTS 141
Cdd:cd04951   302 GD--HNYVVPVSDPQLLAEKIKEIFDMSDEERDILGNKNEYIAKNFSINTIVNEWERLYSG 360
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 16-126 1.37e-11

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 60.81  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  16 KQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSL-LEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGVNGYLIEPEND 94
Cdd:cd03823   235 RQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNGLLFAPGDA 314

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1085344793  95 AMLSDRILDLAT--NLEKAKEFG---RIGKKNLSDEF 126
Cdd:cd03823   315 EDLAAAMRRLLTdpALLERLRAGaepPRSTESQAEEY 351
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 1-89 1.59e-11

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 59.73  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTG-LIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEV 79
Cdd:cd01635   146 LVGGGGEREEEEALAAALGLLERVVIIGgLVDDEVLELLLAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEF 225

                          90
                  ....*....|
gi 1085344793  80 IKDGVNGYLI 89
Cdd:cd01635   226 VVDGENGLLV 235
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 42-142 7.00e-11

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 58.50  E-value: 7.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  42 VDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKN 121
Cdd:cd03825   264 ADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGDVQALAEAIEWLLANPKERESLGERARAL 343

                          90       100
                  ....*....|....*....|.
gi 1085344793 122 LSDEFSTQKMVNQIHELYTSL 142
Cdd:cd03825   344 AENHFDQRVQAQRYLELYKDL 364
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 8-135 2.88e-10

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 56.87  E-value: 2.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   8 ENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLE--GLarVLPQAIMMEKPVISFDLDGAHEVIKDGVN 85
Cdd:cd03800   269 REELAELAEELGLIDRVRFPGRVSRDDLPELYRAADVFVVPSLYEpfGL--TAIEAMACGTPVVATAVGGLQDIVRDGRT 346

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1085344793  86 GYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQI 135
Cdd:cd03800   347 GLLVDPHDPEALAAALRRLLDDPALWQRLSRAGLERARAHYTWESVADQL 396
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 1-115 1.31e-09

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 54.99  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMvkqmnlTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:cd03814   233 VVGDGPARAELEAR------GPDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIV 306

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1085344793  81 KDGVNGYLIEPENDAMLSDRILDLATNLEKAKEFG 115
Cdd:cd03814   307 RPGGTGALVEPGDAAAFAAALRALLEDPELRRRMA 341
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 1-139 3.41e-09

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 53.88  E-value: 3.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLiqPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:PRK15179  553 MVGGGPLLESVREFAQRLGMGERILFTGL--SRRVGYWLTQFNAFLLLSRFEGLPNVLIEAQFSGVPVVTTLAGGAGEAV 630

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1085344793  81 KDGVNGYLIePENDAMLSD------RILDLATNLEKAKEFGRigkKNLSDEFSTQKMVNQIHELY 139
Cdd:PRK15179  631 QEGVTGLTL-PADTVTAPDvaealaRIHDMCAADPGIARKAA---DWASARFSLNQMIASTVRCY 691
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 11-135 1.37e-08

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 52.21  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  11 LREMVKQ-MNLTDRVIFtgliqpeeIPSaiaVVDILvHTSLLEGLARVL--PQ----------AIMMEKPVISFDLDGAH 77
Cdd:cd03805   268 LQRLAEElLNVEDQVLF--------LRS---ISDSQ-KEQLLSSALALLytPSnehfgivpleAMYAGKPVIACNSGGPL 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1085344793  78 EVIKDGVNGYLIEPENDAmLSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQI 135
Cdd:cd03805   336 ETVVEGVTGFLCEPTPEA-FAEAMLKLANDPDLADRMGAAGRKRVKEKFSREAFAERL 392
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 2-130 7.98e-08

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 49.77  E-value: 7.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   2 IGNGEIENSLREMVKQMNLTDRVIFTGLIQPEEIPSAIAV--VDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEV 79
Cdd:cd04946   263 IGGGPLKERLEKLAENKLENVKVNFTGEVSNKEVKQLYKEndVDVFVNVSESEGIPVSIMEAISFGIPVIATNVGGTREI 342

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1085344793  80 IKDGVNGYLiePENDAM---LSDRILDLATNLEKAKEFGRIGKKNLSDEFSTQK 130
Cdd:cd04946   343 VENETNGLL--LDKDPTpneIVSSIMKFYLDGGDYKTMKISARECWEERFNAEV 394
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 5-144 2.17e-07

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 48.54  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   5 GEIENSLREMVKQMNLTDRVIF-TGLIQPEEIPSAIAVVDILV--HTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIK 81
Cdd:cd03822   234 YEGERYRKAAIEELGLQDHVDFhNNFLPEEEVPRYISAADVVVlpYLNTEQSSSGTLSYAIACGKPVISTPLRHAEELLA 313

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1085344793  82 DGvNGYLIEPENDAMLSDRILDLATNLEKAKEFGRIGKKnLSDEFSTQKmvnqIHELYTSLLQ 144
Cdd:cd03822   314 DG-RGVLVPFDDPSAIAEAILRLLEDDERRQAIAERAYA-YARAMTWES----IADRYLRLFN 370
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 43-128 6.42e-07

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 47.32  E-value: 6.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  43 DILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGVNGYLIEPENDAMLsdRILDLATNLEKAKEFGRIGKKNL 122
Cdd:cd03792   281 TVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAV--RILRLLTDPELRRKMGLAAREHV 358


                  ....*.
gi 1085344793 123 SDEFST 128
Cdd:cd03792   359 RDNFLI 364
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 2-54 8.60e-07

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 46.90  E-value: 8.60e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1085344793   2 IGNGEIENSLREMVKQMNLTDRVIFTGLIqpEEIPSAIAVVDILVHTSLLEGL 54
Cdd:cd03812   228 VGEGELKEKIKEKVKELGLEDKVIFLGFR--NDVSEILSAMDVFLFPSLYEGL 278
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
1-132 1.56e-06

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 46.23  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMNLTDRVIFTGLiqPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVI 80
Cdd:PRK15490  434 LVGDGDLRAEAQKRAEQLGILERILFVGA--SRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVISTPAGGSAECF 511

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1085344793  81 KDGVNGYLIEPENDAMLSD--RILDLATNLEKAKE-FGRIGKKNLSDEFSTQKMV 132
Cdd:PRK15490  512 IEGVSGFILDDAQTVNLDQacRYAEKLVNLWRSRTgICQQTQSFLQERFTVEHMV 566
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 19-137 1.12e-05

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 43.51  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  19 NLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLARVLPQAIMMEKPVISFDLDGAHEVIKDGvNGYLIEPeNDAMLS 98
Cdd:cd03821   259 GLGDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAG-CGVVVDP-NVSSLA 336

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1085344793  99 D---RILDLATNLEKAKEFGRIGKKNLSDeFSTQKMVNQIHE 137
Cdd:cd03821   337 EalaEALRDPADRKRLGEMARRARQVEEN-FSWEAVAGQLGE 377
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
5-136 8.21e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 41.31  E-value: 8.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   5 GEIENSLREMVKQmnLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLL-EGLARVLPQAIMMEKPVISFDLDGAHEVIKDG 83
Cdd:PRK15484  242 AAYQKKVLEAAKR--IGDRCIMLGGQPPEKMHNYYPLADLVVVPSQVeEAFCMVAVEAMAAGKPVLASTKGGITEFVLEG 319

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1085344793  84 VNGY-LIEP-ENDAMLSD--RILDLATNLEKAKEFGRIGKKNLSDEFSTQKMVNQIH 136
Cdd:PRK15484  320 ITGYhLAEPmTSDSIISDinRTLADPELTQIAEQAKDFVFSKYSWEGVTQRFEEQIH 376
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 22-130 9.55e-05

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 40.81  E-value: 9.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  22 DRVIFTGLIQPEEIPSAIAVVDilVHTSLLEG--LARVLPQAIMMEKPVISFDLDGAHEVIKDGVNGYLIEPENDAMLSD 99
Cdd:cd03818   281 ERVHFVGKVPYDQYVRLLQLSD--AHVYLTYPfvLSWSLLEAMACGCPVIGSDTAPVREVIRDGRNGLLVDFFDPDALAA 358

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1085344793 100 RILDLATNLEKAKEFGRIGKKNLSDEFSTQK 130
Cdd:cd03818   359 AVLELLEDPDRAAALRRAARRTVERSDSLDV 389
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 10-137 1.34e-04

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 40.42  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793  10 SLREMVKQMNLTDRVIFTGLIQPEEIPSAIAVVDILVHTSLLEGLArvLP--QAIMMEKPVISFDLDGAHEVIKDgvNGY 87
Cdd:cd03809   238 ELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFG--LPvlEAMACGTPVIASNISVLPEVAGD--AAL 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1085344793  88 LIEPENDAMLSDRILDLATNLEKAKEFGRIGKKNLSdEFSTQKMVNQIHE 137
Cdd:cd03809   314 YFDPLDPESIADAILRLLEDPSLREELIRKGLERAK-KFSWEKTAEKTLE 362
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 1-104 4.92e-04

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 38.97  E-value: 4.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085344793   1 MIGNGEIENSLREMVKQMnltDRVIFTGLIQPEEIPSAIAVVDILVHTSLL------EGLARVLPQAIMMEKPVISFDLD 74
Cdd:cd05844   225 IAGDGPLRPALQALAAAL---GRVRFLGALPHAEVQDWMRRAEIFCLPSVTaasgdsEGLGIVLLEAAACGVPVVSSRHG 301

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1085344793  75 GAHEVIKDGVNGYLIePENDAM-LSDRILDL 104
Cdd:cd05844   302 GIPEAILDGETGFLV-PEGDVDaLADALQAL 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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