|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
320-674 |
5.98e-59 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 203.63 E-value: 5.98e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 320 VIASAIPVGRLNLAIITEWPYSDAYSVVYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPIS 399
Cdd:COG5002 34 LLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 400 EIKTGDELEFLAHSLNKMAQSLKEIEELRKQALQAQLLEASLAREKELVEIKDSFLDTASHQLRTPVSAIRWQLELLQSE 479
Cdd:COG5002 114 LAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 480 KISD--TAKELVQGAYEHVEFLSEISSDLINAASYGAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEKDV 557
Cdd:COG5002 194 AADDpeERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 558 SVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGL 637
Cdd:COG5002 274 LVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGL 353
|
330 340 350
....*....|....*....|....*....|....*..
gi 1088191052 638 GLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:COG5002 354 GLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
437-671 |
4.46e-58 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 195.90 E-value: 4.46e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 437 LEASLAREKELVEIKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAK--ELVQGAYEHVEFLSEISSDLINAASYGA 514
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEErrELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 515 GYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQ 594
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1088191052 595 ADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRnvGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPV 671
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG--GTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
347-671 |
2.92e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 191.66 E-value: 2.92e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 347 VYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEIEE 426
Cdd:COG0642 8 LVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 427 LRKQALQAQLLEASLAREKElvEIKDSFLDTASHQLRTPVSAIRWQLELLQsEKISDTAKELVQGAYEHVEFLSEISSDL 506
Cdd:COG0642 88 LLLLLLLLLLALLLLLEEAN--EAKSRFLANVSHELRTPLTAIRGYLELLL-EELDEEQREYLETILRSADRLLRLINDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 507 INAASYGAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQ 586
Cdd:COG0642 165 LDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 587 VTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRnvGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLF 666
Cdd:COG0642 245 VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG--GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322
|
....*
gi 1088191052 667 ISIPV 671
Cdd:COG0642 323 VTLPL 327
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
327-674 |
6.58e-38 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 147.62 E-value: 6.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 327 VGRLNLAIITEWPYSDAYSVVYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDE 406
Cdd:COG4251 154 LLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 407 LEFLAHSLNKMAQSLKEIEELRKQALQAQLLEASLA-REKELVEI---KDSFLDTASHQLRTPVSAIRWQLELLQ---SE 479
Cdd:COG4251 234 LLVLLLLLILLLLLLILVLELLELRLELEELEEELEeRTAELERSneeLEQFAYVASHDLREPLRKISGFSQLLEedyGD 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 480 KISDTAKELVQGAYEHVEFLSEISSDLINAASygAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQ--AKLKISNIPaekdv 557
Cdd:COG4251 314 KLDEEGREYLERIRDAAERMQALIDDLLAYSR--VGRQELEFEPVDLNELLEEVLEDLEPRIEErgAEIEVGPLP----- 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 558 SVSGSYPALRVLFENIIRNAIRYTKSE--GQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRnvGT 635
Cdd:COG4251 387 TVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GT 464
|
330 340 350
....*....|....*....|....*....|....*....
gi 1088191052 636 GLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:COG4251 465 GIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
355-674 |
4.73e-37 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 143.56 E-value: 4.73e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 355 AVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLK----EIEELRK- 429
Cdd:COG5000 12 LLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKeqreELEERRRy 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 430 ------------------------------------QALQAQLLEASLAREKELVEIKDSFLDTA--------------- 458
Cdd:COG5000 92 letilenlpagvivldadgritlanpaaerllgiplEELIGKPLEELLPELDLAELLREALERGWqeeieltrdgrrtll 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 459 -------------------------------------SHQLRTPVSAIRWQLELLQS------EKISDTAKELVQGAYEH 495
Cdd:COG5000 172 vrasplrddgyvivfdditellraerlaawgelarriAHEIKNPLTPIQLSAERLRRkladklEEDREDLERALDTIIRQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 496 VEFLSEISSDLinaASYgAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIR 575
Cdd:COG5000 252 VDRLKRIVDEF---LDF-ARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLK 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 576 NAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFraTnaieTRNVGTGLGLYIAKNIVDGHKGNIWF 655
Cdd:COG5000 328 NAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF--T----TKPKGTGLGLAIVKKIVEEHGGTIEL 401
|
410
....*....|....*....
gi 1088191052 656 ISERDKGTTLFISIPVKRQ 674
Cdd:COG5000 402 ESRPGGGTTFTIRLPLAEE 420
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
306-672 |
6.60e-36 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 138.78 E-value: 6.60e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 306 VVSAGVSRNIFGDTVIASAIPVGRLNLAIITEWPYSDAYSVVYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQF 385
Cdd:COG4191 8 LLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 386 AASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEIEELRKQALQAQLLE------ASLArekelveikdsfldtas 459
Cdd:COG4191 88 LLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAalgelaAGIA----------------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 460 HQLRTPVSAIRWQLELL----QSEKISDTAKELVQGAYEHVEFLSEISSDLINAASYGAGyqvkNFTDVSLTKVIDEVLT 535
Cdd:COG4191 151 HEINNPLAAILGNAELLrrrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 536 QFSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIRNAIR--YTKSEGQVTITTINQADSVEVRVADTGIGIPAEE 613
Cdd:COG4191 227 LLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEV 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1088191052 614 HKMLFRQFFraTnaieTRNV--GTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVK 672
Cdd:COG4191 307 LERIFEPFF--T----TKPVgkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
566-669 |
2.76e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 111.93 E-value: 2.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRnvGTGLGLYIAKNI 645
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGG--GTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1088191052 646 VDGHKGNIWFISERDKGTTLFISI 669
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
565-672 |
2.48e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.28 E-value: 2.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 565 ALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNvGTGLGLYIAKN 644
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIG-GTGLGLSIVKK 83
|
90 100
....*....|....*....|....*...
gi 1088191052 645 IVDGHKGNIWFISERDKGTTLFISIPVK 672
Cdd:smart00387 84 LVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
561-673 |
1.39e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.07 E-value: 1.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 561 GSYPALRVLFENIIRNAIRYTKSEGQVTITtINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNaieTRNVGTGLGLY 640
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 1088191052 641 IAKNIVDGHKGNIWFISERDKGTTLFISIPVKR 673
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
358-654 |
2.85e-25 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 109.64 E-value: 2.85e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 358 ILIILAATVILsRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDElEFLA--HSLNKMAQSLKEieelrkqalqaq 435
Cdd:PRK09470 173 LVTMLVSTPLL-LWLAWSLAKPARKLKNAADEVAQGNLRQHPELETGPQ-EFRQagASFNQMVTALER------------ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 436 lleaslarekeLVEIKDSFLDTASHQLRTPVSAIRWQLELL---QSEkisdtAKELVQGAYEhVEFLSEISSDLINAASY 512
Cdd:PRK09470 239 -----------MMTSQQRLLSDISHELRTPLTRLQLATALLrrrQGE-----SKELERIETE-AQRLDSMINDLLVLSRN 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 513 gagyQVKNFTD---VSLTKVIDEVL--TQFSSQVEQAKLKISNIPAEkdVSVSGSYPALRVLFENIIRNAIRYTKSEGQV 587
Cdd:PRK09470 302 ----QQKNHLEretFKANSLWSEVLedAKFEAEQMGKSLTVSAPPGP--WPINGNPNALASALENIVRNALRYSHTKIEV 375
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1088191052 588 TITTINQadSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIVDGHKGNIW 654
Cdd:PRK09470 376 AFSVDKD--GLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVK 440
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
357-653 |
5.55e-25 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 108.46 E-value: 5.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 357 FILIILAATVILSRVLARQITRPVNILQFAASKIGKGDF-EPISEiKTGDELEFLAHSLNKMAQSLKEIEELRKqalqaq 435
Cdd:PRK09467 158 YTLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIpPPLRE-YGASEVRSVTRAFNQMAAGIKQLEDDRT------ 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 436 LLEASLarekelveikdsfldtaSHQLRTPVSAIRwqlelLQSEKISDTAKELVQGAYEHVEFLSEISSDLINAASYGag 515
Cdd:PRK09467 231 LLMAGV-----------------SHDLRTPLTRIR-----LATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTG-- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 516 yQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEkdvsVSGSYPALRVLFENIIRNAIRYTKseGQVTITTINQA 595
Cdd:PRK09467 287 -QEMPMEMADLNALLGEVIAAESGYEREIETALQPGPIE----VPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEG 359
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1088191052 596 DSVEVRVADTGIGIPAEEHKMLFRQFFRATNAietRN-VGTGLGLYIAKNIVDGHKGNI 653
Cdd:PRK09467 360 KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSA---RGsSGTGLGLAIVKRIVDQHNGKV 415
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
354-653 |
1.28e-24 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 107.80 E-value: 1.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 354 AAVFILIILAATVILSRVLARQITRPVNilqfAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEIEELRKqalq 433
Cdd:PRK10549 170 VALSTLLAALATFLLARGLLAPVKRLVE----GTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRR---- 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 434 aqlleaslarekelveikdSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEhVEFLSEISSDL--INAAS 511
Cdd:PRK10549 242 -------------------DFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAE-VGTLTKLVDDLhqLSLSD 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 512 YGA-GYQvKNFTDVSltKVIDEVLTQFSSQVEQAKLKIS-NIPAEkdVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTI 589
Cdd:PRK10549 302 EGAlAYR-KTPVDLV--PLLEVAGGAFRERFASRGLTLQlSLPDS--ATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHI 376
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1088191052 590 TTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNaieTRNV---GTGLGLYIAKNIVDGHKGNI 653
Cdd:PRK10549 377 SAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEG---SRNRasgGSGLGLAICLNIVEAHNGRI 440
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
423-673 |
1.75e-24 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 105.70 E-value: 1.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 423 EIEELRKQALQAQLLEAS--LARekelveikdsfldTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLS 500
Cdd:COG3852 118 ERKRLERELRRAEKLAAVgeLAA-------------GLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLN 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 501 EISSDLINAASYGAGyqvkNFTDVSLTKVIDEVLTQFSSQVeQAKLKI-----SNIPAekdvsVSGSYPALRVLFENIIR 575
Cdd:COG3852 185 NLVDRLLSFSRPRPP----EREPVNLHEVLERVLELLRAEA-PKNIRIvrdydPSLPE-----VLGDPDQLIQVLLNLVR 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 576 NAIRYTKSEGQVTITT----------INQADSVEVRVADTGIGIPAEEHKMLFRQFFraTnaieTRNVGTGLGLYIAKNI 645
Cdd:COG3852 255 NAAEAMPEGGTITIRTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF--T----TKEKGTGLGLAIVQKI 328
|
250 260
....*....|....*....|....*...
gi 1088191052 646 VDGHKGNIWFISERDKGTTLFISIPVKR 673
Cdd:COG3852 329 VEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
460-672 |
2.97e-24 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 106.74 E-value: 2.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 460 HQLRTPVSAIRWQLELLQSEKisDTAKELVQGAYEHVEFLSEISSDLINAASYgagyQVKNFTDVSLTKVIDEVLTQFSS 539
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPGI--EDKEEYFDIMLSELDRIESIISEFLALAKP----QAVNKEKENINELIQDVVTLLET 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 540 QveqAKLK---ISNIPAEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKM 616
Cdd:COG5805 370 E---AILHniqIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKK 446
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1088191052 617 LFRQFFratnaiETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVK 672
Cdd:COG5805 447 LGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
356-670 |
4.94e-24 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 105.55 E-value: 4.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 356 VFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFE-PISEIKTGDELEFLAHSLNKMaqsLKEIEE-LRKQAlq 433
Cdd:TIGR01386 168 LIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDqRLDPSRAPAELRELAQSFNAM---LGRLEDaFQRLS-- 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 434 aqlleaslarekelveikdSFLDTASHQLRTPVSAIRWQLE-LLQSEKISDTAKELVQGAYEHVEFLSEISSDLINAASY 512
Cdd:TIGR01386 243 -------------------QFSADLAHELRTPLTNLLGQTQvALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARA 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 513 GAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKIsnipaekDVSVSGSYPALRVLFE----NIIRNAIRYTKSEGQVT 588
Cdd:TIGR01386 304 DNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRI-------RVEGEGLVRGDPQMFRraisNLLSNALRHTPDGGTIT 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 589 ITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIVDGHKGNIwFISERDKGTTLFIS 668
Cdd:TIGR01386 377 VRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRA-SAESPDGKTRFILR 455
|
..
gi 1088191052 669 IP 670
Cdd:TIGR01386 456 FP 457
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
459-674 |
5.64e-23 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 102.75 E-value: 5.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 459 SHQLRTPVSAIRWQLELLQSEKISDTAKelvqgaYEHVeFLSEIS--SDLINAASYGAGYQVKNFTDVSLTKVIDEVLTQ 536
Cdd:COG5809 278 AHEIRNPLTSLKGFIQLLKDTIDEEQKT------YLDI-MLSELDriESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPL 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 537 FSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADS-VEVRVADTGIGIPAEEHK 615
Cdd:COG5809 351 LQPQALLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDkVVISVTDEGCGIPEERLK 430
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1088191052 616 MLFRQFFratnaiETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:COG5809 431 KLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLS 483
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
568-671 |
1.02e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 93.33 E-value: 1.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 568 VLFeNIIRNAIRYTkSEGQVTIT-----TINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIA 642
Cdd:cd16922 4 ILL-NLLGNAIKFT-EEGEVTLRvsleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 1088191052 643 KNIVDGHKGNIWFISERDKGTTLFISIPV 671
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
357-671 |
2.06e-22 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 102.80 E-value: 2.06e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 357 FILIILAA-TVILSRVLARQITRP----VNILqfaaSKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKE----IEE- 426
Cdd:PRK15347 301 FALLILVLlTSVLFLLLRRYLAKPlwrfVDII----NKTGPAALEPRLPENRLDELGSIAKAYNQLLDTLNEqydtLENk 376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 427 --LRKQALQAQLLEASLAREKelveiKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISS 504
Cdd:PRK15347 377 vaERTQALAEAKQRAEQANKR-----KSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIIN 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 505 DLINAASYGAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAeKDVSVSGSYPALRV--LFENIIRNAIRYTK 582
Cdd:PRK15347 452 NLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVG-AHVPLYLHLDSLRLrqILVNLLGNAVKFTE 530
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 583 SeGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRAtnaiETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKG 662
Cdd:PRK15347 531 T-GGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQA----DTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVG 605
|
....*....
gi 1088191052 663 TTLFISIPV 671
Cdd:PRK15347 606 SCFSLVLPL 614
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
358-673 |
4.93e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 98.44 E-value: 4.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 358 ILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFE-PISEIKTGDELEFLA----------HSLNKMAQSLKEIEE 426
Cdd:PRK11466 338 MVSLCALILILWRVVYRSVTRPLAEQTQALQRLLDGDIDsPFPETAGVRELDTIGrlmdafrsnvHALNRHREQLAAQVK 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 427 LRKQALQAQLLEASLAR-EKELV-EIKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISS 504
Cdd:PRK11466 418 ARTAELQELVIEHRQARaEAEKAsQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILN 497
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 505 DLINAASYGAGYQVKNFTD--VSLTKVIDEVLTQFSSQVEQAKLKISNIPAEK-DVSVSGSYPALRVLFENIIRNAIRYT 581
Cdd:PRK11466 498 DILDYSAIEAGGKNVSVSDepFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT 577
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 582 KsEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATnaieTRNVGTGLGLYIAKNIVDGHKGNIWFISERDK 661
Cdd:PRK11466 578 D-EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVS----GKRGGTGLGLTISSRLAQAMGGELSATSTPEV 652
|
330
....*....|..
gi 1088191052 662 GTTLFISIPVKR 673
Cdd:PRK11466 653 GSCFCLRLPLRV 664
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
416-670 |
6.13e-21 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 98.12 E-value: 6.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 416 KMAQSLKEIEELRKQALQAqlleaslarekelveiKDSFLDTASHQLRTPVSAIRWQLELLQSekisdtaKELVQGAYEH 495
Cdd:PRK10841 428 KMEESLQEMAQAAEQASQS----------------KSMFLATVSHELRTPLYGIIGNLDLLQT-------KELPKGVDRL 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 496 VEFLSEiSSDLinaasygagyqvknftdvsLTKVIDEVLtQFSsQVEQAKLKI-----------SNIPA----------- 553
Cdd:PRK10841 485 VTAMNN-SSSL-------------------LLKIISDIL-DFS-KIESEQLKIeprefspreviNHITAnylplvvkkrl 542
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 554 ------EKDVSVSGSYPALRV--LFENIIRNAIRYTKSeGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRAT 625
Cdd:PRK10841 543 glycfiEPDVPVALNGDPMRLqqVISNLLSNAIKFTDT-GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVG 621
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1088191052 626 NAIETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:PRK10841 622 TGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
359-674 |
4.46e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 92.34 E-value: 4.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 359 LIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEieelrkqalqaqlle 438
Cdd:PRK10755 68 LVMVSLTLLICFQAVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTS--------------- 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 439 aSLAREKElveikdsFLDTASHQLRTPVSAIRWQLELLQSEKISDtAKELVQgayeHVEFLSEISSDLINAASYGAGYQV 518
Cdd:PRK10755 133 -TLDQERL-------FTADVAHELRTPLAGIRLHLELLEKQHHID-VAPLIA----RLDQMMHTVEQLLQLARAGQSFSS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 519 KNFTDVSLTK-VIDEVLTQFSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADS 597
Cdd:PRK10755 200 GHYQTVKLLEdVILPSQDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGG 279
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1088191052 598 VEVRVADTGIGIPAEEHKMLFRQFFRatnaIETRNVGTGLGLYIAKNIVDGHKGNIwFISERDKGTTLFISIPVKRQ 674
Cdd:PRK10755 280 AVLAVEDEGPGIDESKCGELSKAFVR----MDSRYGGIGLGLSIVSRITQLHHGQF-FLQNRQERSGTRAWVWLPKA 351
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
425-673 |
4.51e-20 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 92.71 E-value: 4.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 425 EELRkqaLQAQLLeaSLAREKEL----VEIKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQG-------AY 493
Cdd:PRK09303 126 ELLQ---LSDELF--VLRQENETlleqLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALieqlqdqAR 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 494 EHVEFLSEISSDLINAASyGAGYQVK-NFTDVSLTKVIDEVLTQFSSQVEQAKLKI-SNIPAekDV-SVSGSYPALRVLF 570
Cdd:PRK09303 201 RQLEEIERLITDLLEVGR-TRWEALRfNPQKLDLGSLCQEVILELEKRWLAKSLEIqTDIPS--DLpSVYADQERIRQVL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 571 ENIIRNAIRYTKSEGQVTITTI---NQadSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRnvGTGLGLYIAKNIVD 647
Cdd:PRK09303 278 LNLLDNAIKYTPEGGTITLSMLhrtTQ--KVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVR 353
|
250 260
....*....|....*....|....*.
gi 1088191052 648 GHKGNIWFISERDKGTTLFISIPVKR 673
Cdd:PRK09303 354 VHYGQIWVDSEPGQGSCFHFTLPVYR 379
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
570-670 |
2.49e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 83.53 E-value: 2.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 570 FENIIRNAIRYtkSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIVDGH 649
Cdd:cd16949 5 LENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQH 82
|
90 100
....*....|....*....|.
gi 1088191052 650 KGNIWFISERDKGTTLFISIP 670
Cdd:cd16949 83 GGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
460-674 |
1.17e-18 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 90.03 E-value: 1.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 460 HQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISSDLInaasYGAGYQVKNFTDVSLTKVIDEVLTQFSS 539
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLL----EFSRPRESQWQPVSLNALVEEVLQLFQT 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 540 QVEQAKLKI-----SNIPAekdVSVSGSypALRVLFENIIRNAIRYTKSEGQVTITTINQADS-VEVRVADTGIGIPAEE 613
Cdd:PRK11360 475 AGVQARVDFeteldNELPP---IWADPE--LLKQVLLNILINAVQAISARGKIRIRTWQYSDGqVAVSIEDNGCGIDPEL 549
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1088191052 614 HKMLFRQFFratnaiETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:PRK11360 550 LKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
427-672 |
4.64e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.55 E-value: 4.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 427 LRKQALQAQLLEASLAREKElvEIKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKelvqgayeHVEFLSEISSDL 506
Cdd:PRK10490 642 LERLTLTASEEQARLASERE--QLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSP--------HARQASEIRQQV 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 507 INAASYgagyqVKNFTDV---------------SLTKVIDEVLTQFSSQVEQAKLKISnIPAEKD-VSVSGsyPALRVLF 570
Cdd:PRK10490 712 LNTTRL-----VNNLLDMariqsggfnlrkewlTLEEVVGSALQMLEPGLSGHPINLS-LPEPLTlIHVDG--PLFERVL 783
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 571 ENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNaiETRNVGTGLGLYIAKNIVDGHK 650
Cdd:PRK10490 784 INLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNK--ESAIPGVGLGLAICRAIVEVHG 861
|
250 260
....*....|....*....|...
gi 1088191052 651 GNIWfISERDKGTTLF-ISIPVK 672
Cdd:PRK10490 862 GTIW-AENRPEGGACFrVTLPLE 883
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
267-674 |
5.24e-18 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 87.00 E-value: 5.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 267 YAYLIDDSGFLIAATAGKNLPKDTTIKNTLTEKLDKSVGVVSAGVSRNIFGDTVIASAIPVGRLNLAIITEWPYSDAYSV 346
Cdd:COG2972 72 LLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 347 VYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPIsEIKTGDELEFLAHSLNKMAQSLKEIE- 425
Cdd:COG2972 152 LFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRL-EVSGNDEIGILARSFNEMVERIKELIe 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 426 ----------ELRKQALQAQL--------LE--ASLAREKELVEIKDSFLDTAS---HQLRTPVSAIRWQLELlqsekis 482
Cdd:COG2972 231 evyelelekkEAELKALQAQInphflfntLNsiRWLAELEDPEEAEEMLEALSKllrYSLSKGDELVTLEEEL------- 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 483 dtakelvqgayEHVE-FLSeissdlINAASYGAGYQVknftDVSLTKVIDEVLTqfssqveqakLKISnipaekdvsvsg 561
Cdd:COG2972 304 -----------ELIKsYLE------IQKLRFGDRLEV----EIEIDEELLDLLI----------PKLI------------ 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 562 sypaLRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFfratnaiETRNVGTGLGLYI 641
Cdd:COG2972 341 ----LQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRN 409
|
410 420 430
....*....|....*....|....*....|....*.
gi 1088191052 642 AKNIVD---GHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:COG2972 410 VRERLKlyyGEEYGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
406-670 |
1.64e-17 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 85.98 E-value: 1.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 406 ELEFLAHSLNKMaqsLKEIEEL-RKQAlqaqlleaslarekelveikdSFLDTASHQLRTPVSAIRWQLELLQSEkiSDT 484
Cdd:PRK09835 240 ELEQLVLSFNHM---IERIEDVfTRQS---------------------NFSADIAHEIRTPITNLITQTEIALSQ--SRS 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 485 AKELVQGAYEHVEFLSEIS---SDLINAAsygagyQVKNfTDVSLTKVI----DEVLTQFS-----SQVEQAKLKISNIP 552
Cdd:PRK09835 294 QKELEDVLYSNLEELTRMAkmvSDMLFLA------QADN-NQLIPEKKMldlaDEVGKVFDffeawAEERGVELRFVGDP 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 553 AekdvSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRN 632
Cdd:PRK09835 367 C----QVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKG 442
|
250 260 270
....*....|....*....|....*....|....*...
gi 1088191052 633 VGTGLGLYIAKNIVDGHKGNIWFISERDkGTTLFISIP 670
Cdd:PRK09835 443 EGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLP 479
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-670 |
2.04e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 78.10 E-value: 2.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNvGTGLGLYIAKNI 645
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKL 84
|
90 100
....*....|....*....|....*..
gi 1088191052 646 VD--GHKgnIWFISERDKGTTLFISIP 670
Cdd:cd16948 85 CDklGHK--IDVESEVGEGTTFTITFP 109
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
354-670 |
6.98e-17 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 84.90 E-value: 6.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 354 AAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEI-EELRKQAL 432
Cdd:PRK11107 180 AFLMLLLGIGLALLFAFRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGNMLGELDMLKNGINAMAMSLSAYhEEMQQNID 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 433 QA-------------QLLEASLA--REKELVEIKDSFLDTASHQLRTPVSAI----RW---------QLELLQSekISDT 484
Cdd:PRK11107 260 QAtsdlretleqmeiQNVELDLAkkRAQEAARIKSEFLANMSHELRTPLNGVigftRQtlktpltptQRDYLQT--IERS 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 485 AKELvqgayehvefLSeISSDLINAASYGAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKIS-NIPAEKDVSVSGSy 563
Cdd:PRK11107 338 ANNL----------LA-IINDILDFSKLEAGKLVLENIPFSLRETLDEVVTLLAHSAHEKGLELTlNIDPDVPDNVIGD- 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 564 pALRV--LFENIIRNAIRYTKSeG--QVTITTINQAD---SVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTG 636
Cdd:PRK11107 406 -PLRLqqIITNLVGNAIKFTES-GniDILVELRALSNtkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTG 483
|
330 340 350
....*....|....*....|....*....|....
gi 1088191052 637 LGLYIAKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:PRK11107 484 LGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
359-653 |
7.71e-17 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 83.74 E-value: 7.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 359 LIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKtGDELeflahslNKMAQSLkeiEELRKQalqaqlLE 438
Cdd:PRK11100 189 ALLLGIALLIGAGVVWWLNRSIRRLTRYADAVTEGKPVPLPKLG-SSEL-------RELAQAL---ESMRVK------LE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 439 AslareKELVEikdSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISSDLINAASYGAGYQV 518
Cdd:PRK11100 252 G-----KAYVE---QYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQEL 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 519 KNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAekDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADSV 598
Cdd:PRK11100 324 EVLEPVALAALLEELVEAREAQAAAKGITLRLRPD--DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQV 401
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1088191052 599 EVRVADTGIGIPAEEHKMLFRQFF---RAtnaiETRNVGTGLGLYIAKNIVDGHKGNI 653
Cdd:PRK11100 402 ALSVEDQGPGIPDYALPRIFERFYslpRP----ANGRKSTGLGLAFVREVARLHGGEV 455
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-670 |
9.43e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 76.21 E-value: 9.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSE--GQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRatnaIETRNV--GTGLGLYI 641
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQR----LHSREEyeGTGVGLAI 76
|
90 100
....*....|....*....|....*....
gi 1088191052 642 AKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16921 77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-655 |
1.67e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 75.58 E-value: 1.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNI 645
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNI 84
|
90
....*....|
gi 1088191052 646 VDGHKGNIWF 655
Cdd:cd16946 85 ALAHGGTISA 94
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-670 |
1.48e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 72.80 E-value: 1.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETrnVGTGLGLYIAKNI 645
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT--EGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 1088191052 646 VDGHKGNIWFISErDKGTTLFISIP 670
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
428-672 |
1.63e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 79.45 E-value: 1.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 428 RKQALQAQLLEASLAREKELVEIKDSFLDTAsHQLRTPVSAIR-WQLELLQSEKISDTAKELVQGAYEHVEFLSEISSDL 506
Cdd:PRK10364 215 RRYLRSRQLLQDEMKRKEKLVALGHLAAGVA-HEIRNPLSSIKgLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSEL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 507 INAasygagyqVK----NFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEKDVSVSGSYPALRVLFENIIRNAIRYTK 582
Cdd:PRK10364 294 LEL--------VKpthlALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIG 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 583 SEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKG 662
Cdd:PRK10364 366 QHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKG 439
|
250
....*....|
gi 1088191052 663 TTLFISIPVK 672
Cdd:PRK10364 440 ATFTLWLPVN 449
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
451-672 |
2.02e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 80.55 E-value: 2.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 451 KDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAK-ELVQGAYEHVEFLSEISSDLINAASYGAG-YQVK-NFTDVslt 527
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRvEAISLAYATGQSLLGLIGEILDVDKIESGnYQLQpQWVDI--- 788
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 528 kvidevltqfSSQVEQAKLKISNIPAEKDV--SVSGSYP----------ALRVLFENIIRNAIRYTkSEGQVTITT--IN 593
Cdd:PRK09959 789 ----------PTLVQNTCHSFGAIAASKSIalSCSSTFPdhylvkidpqAFKQVLSNLLSNALKFT-TEGAVKITTslGH 857
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 594 QADS---VEVRVADTGIGIPAEEHKMLFRQFFRATNAieTRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:PRK09959 858 IDDNhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAG--RQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
..
gi 1088191052 671 VK 672
Cdd:PRK09959 936 VE 937
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
383-653 |
2.55e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 78.88 E-value: 2.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 383 LQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLkeieelrkqalqaqllEASLAREKELVeikdsflDTASHQL 462
Cdd:PRK10604 167 LEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNI----------------NALIASKKQLI-------DGIAHEL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 463 RTPVSAIRWQLELLQSekisdtakelvqgayehvefLSEISSDLINaasygagyqvknfTDVS-LTKVIDEVLTQFSSQV 541
Cdd:PRK10604 224 RTPLVRLRYRLEMSDN--------------------LSAAESQALN-------------RDIGqLEALIEELLTYARLDR 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 542 EQAKLKISNI--PA------------------EKDVSVSGSYPAL------RVLfENIIRNAIRYtkSEGQVTITTINQA 595
Cdd:PRK10604 271 PQNELHLSEPdlPAwlsthladiqavtpektvRLDTPHQGDYGALdmrlmeRVL-DNLLNNALRY--AHSRVRVSLLLDG 347
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1088191052 596 DSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIVDGHKGNI 653
Cdd:PRK10604 348 NQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSV 405
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-673 |
3.12e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 71.85 E-value: 3.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNI 645
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 1088191052 646 VDGHKGNIWFISERDKGTTLFISIPVKR 673
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
568-670 |
3.62e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 71.66 E-value: 3.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 568 VLFeNIIRNAIR----YTKSEGQVTI-TTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNVGTGLGLYIA 642
Cdd:cd16920 4 VLI-NLVRNGIEamseGGCERRELTIrTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 1088191052 643 KNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
428-671 |
4.22e-15 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 79.21 E-value: 4.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 428 RKQAlQAQLLEASlaREKElveikdSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISSDLI 507
Cdd:PRK11091 269 RKRY-QDALEKAS--RDKT------TFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIHVSAITLGNIFNDII 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 508 NAASYGAgYQVKNFTD-VSLTKVIDEVLTQFSSQVEQAKLKIsnipaekDVSVSGSYPA--------LRVLFENIIRNAI 578
Cdd:PRK11091 340 DMDKMER-RKLQLDNQpIDFTDFLADLENLSGLQAEQKGLRF-------DLEPLLPLPHkvitdgtrLRQILWNLISNAV 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 579 RYTKsEGQVTITTI-NQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRN-VGTGLGLYIAKNIVDGHKGNIWFI 656
Cdd:PRK11091 412 KFTQ-QGGVTVRVRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPaTGTGIGLAVSKRLAQAMGGDITVT 490
|
250
....*....|....*
gi 1088191052 657 SERDKGTTLFISIPV 671
Cdd:PRK11091 491 SEEGKGSCFTLTIHA 505
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
554-655 |
7.54e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 70.90 E-value: 7.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 554 EKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITtINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETrnv 633
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNYG--- 77
|
90 100
....*....|....*....|..
gi 1088191052 634 GTGLGLYIAKNIVDGHKGNIWF 655
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFL 99
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
419-672 |
1.35e-14 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 76.44 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 419 QSLKEIEELRKQALQAQLLE------ASLArekelveikdsfldtasHQLRTPVSAIRWQLELLQSEKISD-TAKELVQG 491
Cdd:COG5806 180 ENLIENILLRKELQRAEKLEvvselaASIA-----------------HEVRNPLTVVRGFIQLLQEPELSDeKRKQYIRI 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 492 AYEHVEFLSEISSDLINAASYgagyQVKNFTDVSLTKVIDEVLTQFSS-----QVE-QAKLkisnipaEKDVSVSGSYPA 565
Cdd:COG5806 243 ALEELDRAEAIITDYLTFAKP----QPEKLEKIDVSEELEHVIDVLSPyanmnNVEiQTEL-------EPGLYIEGDRQK 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNVGTGLGLYIAKNI 645
Cdd:COG5806 312 LQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRI 385
|
250 260
....*....|....*....|....*..
gi 1088191052 646 VDGHKGNIWFISERDKGTTLFISIPVK 672
Cdd:COG5806 386 IEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
488-674 |
2.03e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 75.66 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 488 LVQ-GAYEH-VEFLSEISSDlINAASYGAGYQVKNftdvsltKVIDEVLTQFSSQVEQAKLKI-----SNIPAEKDVSvs 560
Cdd:COG3290 210 LLQlGEYDEaLEYIDEISEE-LQELIDSLLSRIGN-------PVLAALLLGKAARARERGIDLtididSDLPDLPLSD-- 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 561 gsyPALRVLFENIIRNAIRYTK----SEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRN-VGT 635
Cdd:COG3290 280 ---TDLVTILGNLLDNAIEAVEklpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF------STKLgEGR 350
|
170 180 190
....*....|....*....|....*....|....*....
gi 1088191052 636 GLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:COG3290 351 GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
564-671 |
5.31e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 68.22 E-value: 5.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 564 PALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNV--GTGLGLYI 641
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF------TTKPVgeGTGLGLSL 75
|
90 100 110
....*....|....*....|....*....|
gi 1088191052 642 AKNIVDGHKGNIWFISERDKGTTLFISIPV 671
Cdd:cd16943 76 SYRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
570-653 |
6.70e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.18 E-value: 6.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 570 FENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAiETRNVGTGLGLYIAKNIVDGH 649
Cdd:cd16975 9 LINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTS-RRSGGHYGMGLYIAKNLVEKH 87
|
....
gi 1088191052 650 KGNI 653
Cdd:cd16975 88 GGSL 91
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-662 |
1.83e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.01 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYtkSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETrnVGTGLGLYIAKNI 645
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT--SGTGLGLAIVQRI 76
|
90
....*....|....*..
gi 1088191052 646 VDGHKGNIwFISERDKG 662
Cdd:cd16950 77 SDAHGGSL-TLANRAGG 92
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
349-662 |
4.77e-12 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 68.94 E-value: 4.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 349 SLVNQAAVFILIILAATVILSRVLA-----RQITRPVNILQFAASKIGKGDFE-PISeIKTGDELEFLAHSLNKMAQSLK 422
Cdd:COG4192 319 QLVQQSGILLLAIALLSLLLAVLINyfyvrRRLVKRLNALSDAMAAIAAGDLDvPIP-VDGNDEIGRIARLLRVFRDQAI 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 423 EieelRKQALQAQLlEASLAREKELVEIKDSFLDTA------------SHQLRTPVSAIRwqlELLQSEKISDTAK--EL 488
Cdd:COG4192 398 E----KTQELETEI-EERKRIEKNLRQTQDELIQAAkmavvgqtmtslAHELNQPLNAMS---MYLFSAKKALEQEnyAQ 469
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 489 VQGAYEHVEFLSEISSDLINAASYGAGYQVKNFTDVSLTKVIDE--VLTQFSSQVEQAKLKISNipaekDVSVSGSYPAL 566
Cdd:COG4192 470 LPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQawELVESRAKPQQITLHIPD-----DLMVQGDQVLL 544
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 567 RVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHkmLFRQFfratnaIETRNVGTGLGLYIAKNIV 646
Cdd:COG4192 545 EQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVDK--LFTPF------TTTKEVGLGLGLSICRSIM 616
|
330
....*....|....*.
gi 1088191052 647 DGHKGNIWFISERDKG 662
Cdd:COG4192 617 QQFGGDLYLASTLERG 632
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
326-662 |
5.31e-12 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 68.52 E-value: 5.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 326 PVGRLNLAIITEWPYSD--AYSVVYS-----LVnqAAVFILIILaaTVILSRVLarqitRPVNILQFAASKIGKGDFEPI 398
Cdd:PRK10337 137 PDGKYRIVVGQEWEYREdmALAIVAGqlipwLV--ALPIMLIIL--MVLLGREL-----APLKKLALALRMRDPDSETPL 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 399 SEIKTGDELEFLAHSLNKMAQslkeieelRKQALqaqlleasLAREKElveikdsFLDTASHQLRTPVSAIRWQLE---- 474
Cdd:PRK10337 208 NATGVPSEVRPLVEALNQLFA--------RTHAM--------MVRERR-------FTSDAAHELRSPLAALKVQTEvaql 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 475 -----------LLQSEKISDTAKELVqgayEHVEFLSEISSdlinaasygaGYQVKNFTDVSLTKVIDEVLTQFSSQVEQ 543
Cdd:PRK10337 265 sdddpqarkkaLLQLHAGIDRATRLV----DQLLTLSRLDS----------LDNLQDVAEIPLEDLLQSAVMDIYHTAQQ 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 544 AKLKIS-NIPAEkDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQadsvEVRVADTGIGIPAEEHKMLFRQFF 622
Cdd:PRK10337 331 AGIDVRlTLNAH-PVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFY 405
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1088191052 623 RATNAIETrnvGTGLGLYIAKNIVDGHKGNIWFISERDKG 662
Cdd:PRK10337 406 RPPGQEAT---GSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
570-670 |
5.95e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 62.80 E-value: 5.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 570 FENIIRNA-----------IRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFfratnaIETRNVGTGLG 638
Cdd:cd16918 5 FLNLVRNAaqalagsggeiILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPM------VSGRENGTGLG 78
|
90 100 110
....*....|....*....|....*....|...
gi 1088191052 639 LYIAKNIVDGHKGNIWFISErdKGTTLF-ISIP 670
Cdd:cd16918 79 LAIAQNIVSQHGGVIECDSQ--PGHTVFsVSLP 109
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
244-669 |
2.07e-11 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 67.06 E-value: 2.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 244 IRGELSLKPLERIFAQATLGTRGYAYLIDDSGFLIAATAGKNLPKDTTIKNTLTEKLDKSVGVVSAGVSRNIFGDTVIAS 323
Cdd:COG2770 105 LLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIA 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 324 AIPVGRLNLAIITEWPYSDAYSVVYSLVNQAAVFILIILAAtVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKT 403
Cdd:COG2770 185 ALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLA-LLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSR 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 404 GDELEFLAHSLNKMAQSLKEIEELRKQALQAQLLEASLAREKELVEikDSFLDTASHQLRTPVSAIRWQLELLQSEKISD 483
Cdd:COG2770 264 KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLEL--LLALLLLLLALLLLAAAALLLELLLLLLLALL 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 484 TAKELVQGAYEHVEFLSEISSDLINAASYGAGYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKISNIPAEKDVSVSGSY 563
Cdd:COG2770 342 LLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALAL 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 564 PALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAK 643
Cdd:COG2770 422 LALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAA 501
|
410 420
....*....|....*....|....*.
gi 1088191052 644 NIVDGHKGNIWFISERDKGTTLFISI 669
Cdd:COG2770 502 AEELAEELLLLEGLLLLLLLEAEALE 527
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
454-670 |
4.77e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 65.42 E-value: 4.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 454 FLDTASHQLRTPVSAIRWQLELLQS--------EKISDTAKELVQGAYEHVEFLSEISSdlINAAsygagyqvknfTDVS 525
Cdd:PRK11006 207 FFANVSHELRTPLTVLQGYLEMMQDqplegalrEKALHTMREQTQRMEGLVKQLLTLSK--IEAA-----------PTID 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 526 LTKVID-----EVLTQFSSQVEQAKLKIS-NIpaEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADSVE 599
Cdd:PRK11006 274 LNEKVDvpmmlRVLEREAQTLSQGKHTITfEV--DNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAE 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1088191052 600 VRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:PRK11006 352 FSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
245-669 |
5.58e-11 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 65.29 E-value: 5.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 245 RGELSLKPLERIFAQATLGTRGYAYLIDDSGFLIAATAGKNLPKDTTIKNTLTEKLDKSVGVVSAGVSRNIFGDTVIASA 324
Cdd:COG3850 11 LLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 325 IPVGRLNLAIITEWPYSDAYSVVYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTG 404
Cdd:COG3850 91 SLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 405 DELEFLAHSLNKMAQSLKEIEELRKQALQAQLLEASLAREKELVEIKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDT 484
Cdd:COG3850 171 DELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAE 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 485 AKELVQGAYEHVEFLSEISSDLINAASYGAGYQVKNFTDVSLTKVIDEVLTQfssqvEQAKLKISNIPAEKDVSVSGSYP 564
Cdd:COG3850 251 SELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAE-----EALLLLVELAALLLLLLLQAIAN 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 565 ALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKN 644
Cdd:COG3850 326 ASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVD 405
|
410 420
....*....|....*....|....*
gi 1088191052 645 IVDGHKGNIWFISERDKGTTLFISI 669
Cdd:COG3850 406 VEGGVAGEGGLVVLIVSIIAGGEAI 430
|
|
| Cache_3-Cache_2 |
pfam17201 |
Cache 3/Cache 2 fusion domain; The Cache_3-Cache_2 domain likely originated as a fusion of ... |
198-353 |
1.22e-10 |
|
Cache 3/Cache 2 fusion domain; The Cache_3-Cache_2 domain likely originated as a fusion of sCache_3 and sCache_2 domains.
Pssm-ID: 465378 [Multi-domain] Cd Length: 298 Bit Score: 63.14 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 198 FYPSSELFKQIAAGKNYIGRPyKTLEGYFITLGAPVKNSNGKVIG----GIRGELSLKPLERIFAQATLGTRGYAYLIDD 273
Cdd:pfam17201 132 IPASSPVYKAVLAGETYVGRA-KVFGKWYVTAYEPIRDADGKVIGilyvGVPQDEALASLRKAIKKVKIGKTGYLYVLDG 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 274 SG-----FLIAAT-AGKNL--PKDTTIKNTLTEKLDKSVGVVSAGVSRNIFGDTVIASAIPVGRLNLAIITEWPYSDAYS 345
Cdd:pfam17201 211 KGdqkgkFIVHPTlEGKNIldAKDADGEPFVKKLLQKKVGSLEYPWKADAAGRDKLAAFTYFEPWDWVIVASVYEDEFLA 290
|
....*...
gi 1088191052 346 VVYSLVNQ 353
Cdd:pfam17201 291 ATNRLLNQ 298
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
567-670 |
1.95e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 58.27 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 567 RVLFeNIIRNAIRYTKSEGQVT-ITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNI 645
Cdd:cd16925 7 RVVL-NLLSNAFKFTPDGGRIRcILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEF 85
|
90 100
....*....|....*....|....*.
gi 1088191052 646 VDGHKGNIwFISERDKGTTLF-ISIP 670
Cdd:cd16925 86 VELHGGTV-TVSDAPGGGALFqVELP 110
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
567-653 |
2.03e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 58.21 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 567 RVLfENIIRNAIRYTKSegQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIV 646
Cdd:cd16939 3 RAL-DNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
....*..
gi 1088191052 647 DGHKGNI 653
Cdd:cd16939 80 LWHGGHV 86
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
424-674 |
4.06e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 63.16 E-value: 4.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 424 IEELRKQAlQAQLLEASLAREKELvEIKDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAkelvqgAYEHVEflsEIS 503
Cdd:PRK13837 425 IERRRLET-ERDALERRLEHARRL-EAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSR------AARYID---EII 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 504 S------DLINAA-SYGAgYQVKNFTDVSLTKVIDEVLTQFS-SQVEQAKLKISNipAEKDVSVSGSYPALRVLFENIIR 575
Cdd:PRK13837 494 SagararLIIDQIlAFGR-KGERNTKPFDLSELVTEIAPLLRvSLPPGVELDFDQ--DQEPAVVEGNPAELQQVLMNLCS 570
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 576 NAIRYTKSEGQVTIT---------------TINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNVGTGLGLY 640
Cdd:PRK13837 571 NAAQAMDGAGRVDISlsraklrapkvlshgVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLA 644
|
250 260 270
....*....|....*....|....*....|....
gi 1088191052 641 IAKNIVDGHKGNIWFISERDKGTTLFISIPVKRQ 674
Cdd:PRK13837 645 TVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSK 678
|
|
| HAMP |
pfam00672 |
HAMP domain; |
371-423 |
4.69e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 55.32 E-value: 4.69e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1088191052 371 VLARQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKE 423
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
227-337 |
3.81e-09 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 57.73 E-value: 3.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 227 ITLGAPVKNSNGKVIGGIRGELSLKPLERIFAQATLGTRGYAYLIDDSGFLIAATAGKNLPKDTTIK-NTLTEKLDKSVG 305
Cdd:pfam02743 128 LTIARPIYDDDGEVIGVLVADLDLDTLQELLSQIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFlGKSLADALPGSG 207
|
90 100 110
....*....|....*....|....*....|..
gi 1088191052 306 VVSAGVSRNifGDTVIASAIPVGRLNLAIITE 337
Cdd:pfam02743 208 ITEIAVDLD--GEDYLVAYAPIPGTGWTLVVV 237
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
569-653 |
4.75e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.50 E-value: 4.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 569 LFENIIRNAIRYTKSE-GQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIETRNVGTGLGLYIAKNIVD 647
Cdd:cd16953 4 VLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQIIE 83
|
....*.
gi 1088191052 648 GHKGNI 653
Cdd:cd16953 84 AHGGIS 89
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
377-421 |
7.57e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 51.68 E-value: 7.57e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1088191052 377 TRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSL 421
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
572-672 |
9.88e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 57.78 E-value: 9.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 572 NIIRNAIRYTKSEGQvTIT----TINQAD--------SVEVRVADTGIGIPAEEHKMLFRQFfratnaIETRNVGTGLGL 639
Cdd:PRK11073 244 NIVRNALQALGPEGG-TITlrtrTAFQLTlhgeryrlAARIDIEDNGPGIPPHLQDTLFYPM------VSGREGGTGLGL 316
|
90 100 110
....*....|....*....|....*....|....
gi 1088191052 640 YIAKNIVDGHKGNIWFISErdKGTTLF-ISIPVK 672
Cdd:PRK11073 317 SIARNLIDQHSGKIEFTSW--PGHTEFsVYLPIR 348
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
374-426 |
1.03e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 51.48 E-value: 1.03e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1088191052 374 RQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEIEE 426
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
572-670 |
1.40e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.00 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 572 NIIRNAIRYT--KSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNVGTGLGLYIAKNIVDGH 649
Cdd:PRK11086 440 NLIENALEAVggEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENL 513
|
90 100
....*....|....*....|.
gi 1088191052 650 KGNIWFISERDKGTTLFISIP 670
Cdd:PRK11086 514 GGSIAVESEPGVGTQFFVQIP 534
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
425-673 |
1.71e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 55.78 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 425 EELRKQALQAQLLEASLAREKELVEI-KDsfL-DTASHQLrtpvSAIRWQLELL---------QSEKISDTAKELVQGAY 493
Cdd:COG4585 32 AERAAELERELAARAEEAREEERRRIaRE--LhDGVGQSL----SAIKLQLEAArrlldadpeAAREELEEIRELAREAL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 494 EHVEflsEISSDLINAAsygagyqvknFTDVSLTKVIDEVLTQFSsqvEQAKLKIsnipaekDVSVSGSYPAL------- 566
Cdd:COG4585 106 AELR---RLVRGLRPPA----------LDDLGLAAALEELAERLL---RAAGIRV-------ELDVDGDPDRLppevela 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 567 --RVLFEnIIRNAIRYTKSeGQVTITTINQADSVEVRVADTGIGIPAEEHKmlfrqffratnaietrnvGTGLGLyiaKN 644
Cdd:COG4585 163 lyRIVQE-ALTNALKHAGA-TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------------GGGLGL---RG 219
|
250 260 270
....*....|....*....|....*....|..
gi 1088191052 645 I---VDGHKGNIWFISERDKGTTLFISIPVKR 673
Cdd:COG4585 220 MrerAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
572-670 |
1.95e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 52.77 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 572 NIIRNAIRYTKSEGQVTITTINQ---------------ADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNVG-- 634
Cdd:cd16919 7 NLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFF------TTKEVGkg 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1088191052 635 TGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
451-515 |
2.47e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.06 E-value: 2.47e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088191052 451 KDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISSDLINAASYGAG 515
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
553-653 |
3.21e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 52.63 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 553 AEKDVSVSGSY-PALRVLFE---------NIIRNAIRYtkSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFF 622
Cdd:cd16954 15 QRKGVSISLDIsPELRFPGErndlmellgNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQ 92
|
90 100 110
....*....|....*....|....*....|.
gi 1088191052 623 RAtnaiETRNVGTGLGLYIAKNIVDGHKGNI 653
Cdd:cd16954 93 RL----DEQRPGQGLGLAIAKEIVEQYGGEL 119
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
572-662 |
9.79e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 50.53 E-value: 9.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 572 NIIRNAIRYTKS--EGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaiETRNV--GTGLGLYIAKNIVD 647
Cdd:cd16976 7 NLLQNALDAMGKveNPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF------TTKPVgkGTGLGLSISYGIVE 80
|
90
....*....|....*
gi 1088191052 648 GHKGNIWFISERDKG 662
Cdd:cd16976 81 EHGGRLSVANEEGAG 95
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
572-670 |
1.09e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 50.36 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 572 NIIRNAI----RYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFrATNAIETRnvgtGLGLYIAKNIVD 647
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-STKGQGER----GIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 1088191052 648 GHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
342-424 |
1.80e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 54.26 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 342 DAYSVVYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSL 421
Cdd:COG0840 172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
...
gi 1088191052 422 KEI 424
Cdd:COG0840 252 REL 254
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
451-515 |
1.93e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 48.33 E-value: 1.93e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1088191052 451 KDSFLDTASHQLRTPVSAIRWQLELLQSEKISDTAKELVQGAYEHVEFLSEISSDLINAASYGAG 515
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
449-510 |
8.76e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 46.44 E-value: 8.76e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1088191052 449 EIKDSFLDTASHQLRTPVSAIRWQLELLQSE-KISDTAKELVQGAYEHVEFLSEISSDLINAA 510
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEElLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
573-671 |
1.10e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.99 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 573 IIRNAIRYT---KSEGQVTITTINQADSVEVRVADTGIGIPAEehkmlfrqffRATNAIETRNVGtGLGLYIAKNIVDGh 649
Cdd:COG2172 42 AVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPE----------DLPDPYSTLAEG-GRGLFLIRRLMDE- 109
|
90 100
....*....|....*....|..
gi 1088191052 650 kgniWFISERDKGTTLFISIPV 671
Cdd:COG2172 110 ----VEYESDPGGTTVRLVKRL 127
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
550-669 |
1.10e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 48.28 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 550 NIPaEKDVSVSGSYPALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAIE 629
Cdd:cd16947 6 NIP-DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRN 84
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1088191052 630 TRNVGTGLGLYIAKNIVDGHKGNIWFISERDKGTTLFISI 669
Cdd:cd16947 85 SAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-653 |
1.39e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 47.46 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRATNAiETRNVGTGLGLYIAKNI 645
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRP-HSGQKSTGLGLAFVQEV 83
|
....*...
gi 1088191052 646 VDGHKGNI 653
Cdd:cd16945 84 AQLHGGRI 91
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-670 |
3.23e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 46.29 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAeehkmlfrqffRATNAIETR-NVGTGLGLY-IAK 643
Cdd:cd16924 6 LQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDP-----------KVLNILGKKpKEGNGIGLYnVHQ 74
|
90 100
....*....|....*....|....*....
gi 1088191052 644 NIVD--GHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16924 75 RLILlfGEDYGIHIASEPDKGTRITFTIP 103
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-670 |
2.23e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 43.95 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 565 ALRVLFENIIRNAIRYTKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFratnaieTRNVGTGLGLYIAKN 644
Cdd:cd16957 5 ALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV-------TSEKGTGTALENLNR 77
|
90 100
....*....|....*....|....*....
gi 1088191052 645 IVD---GHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16957 78 RLIglfGSEACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
530-670 |
2.32e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 44.33 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 530 IDEVLTQFSSQVE----QAKLKISNIPAEKDVSVSGSYPALRVLFEnIIRNAIRYT---KSEGQVTITTINQADSVEVRV 602
Cdd:cd16951 1 LGEYINRIASAINaihaVGDIRINITGDTGPVSSEVATAIGLVVNE-LLQNALKHAfsdREGGTITIRSVVDGDYLRITV 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1088191052 603 ADTGIGIPAEEhkmlfrqffratNAIETRNvgtgLGLYIAKNIVDGHKGNIWFISERDKGTTLFISIP 670
Cdd:cd16951 80 IDDGVGLPQDE------------DWPNKGS----LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
565-662 |
2.40e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 43.68 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 565 ALRVLFENIIRNAIRYTKS----EGQVTI-TTINQADSVEVRVADTGIGIPAEEHKMLFRQFfratnaIETRNVGTGLGL 639
Cdd:cd16944 4 QISQVLTNILKNAAEAIEGrpsdVGEVRIrVEADQDGRIVLIVCDNGKGFPREMRHRATEPY------VTTRPKGTGLGL 77
|
90 100
....*....|....*....|...
gi 1088191052 640 YIAKNIVDGHKGNIwFISERDKG 662
Cdd:cd16944 78 AIVKKIMEEHGGRI-SLSNREAG 99
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
240-673 |
4.88e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 46.44 E-value: 4.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 240 VIGGIRGELSLKPLERIFAQATLGTRGYAYLIDDSGFLIAATAGKNLPKDTTIKNTLTEKLDKSVGVVSAGVSRNIFGDT 319
Cdd:COG3920 100 LALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLL 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 320 VIASAIPVGRLNLAIITEWPYSDAYSVVYSLVNQAAVFILIILAATVILSRVLARQITRPVNILQFAASKIGKGDFEPIS 399
Cdd:COG3920 180 LLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLL 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 400 EIKTGDELEFLAHSLNKMAQSLKEIEELRKQALQAQlleASLAREkelVE--IKDSFldtashQLrtpVSAIrwqLELlQ 477
Cdd:COG3920 260 LLLLLRALLLLAAGIRLVITERKRAEEELEASLEEK---ELLLRE---LHhrVKNNL------QV---VSSL---LRL-Q 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 478 SEKISD-TAKELVQGAYEHVEFLSEISSDLinaasygagYQVKNFTDVSLTKVIDEVLTQFSSQVEQAKLKIS------N 550
Cdd:COG3920 321 ARRADDpEAREALEESQNRIQALALVHELL---------YQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIEldgpdvE 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 551 IPAEKDVSVsgsypALrVLFEnIIRNAIRY---TKSEGQVTITTINQADSVEVRVADTGIGIPAEehkmlfrqffratna 627
Cdd:COG3920 392 LPADAAVPL-----GL-ILNE-LVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED--------------- 449
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1088191052 628 IETRNvGTGLGLYIAKNIVDGHKGNIwfISERDKGTTLFISIPVKR 673
Cdd:COG3920 450 VDPPA-RKGLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAE 492
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
355-467 |
5.17e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 46.59 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 355 AVFILIILAATVILSRvlaRQITRPVNILQFAASKIGKGDFEPISEIKTGDELEFLAHSLNKMAQSLKEIE---ELRKQA 431
Cdd:PRK10600 131 AVFMALLLVFTIIWLR---RRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELAESYavlEQRVQE 207
|
90 100 110
....*....|....*....|....*....|....*.
gi 1088191052 432 LQAQLleaslaREKELVEikdSFLDTASHQLRTPVS 467
Cdd:PRK10600 208 KTAGL------EQKNQIL---SFLWQANRRLHSRAP 234
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
353-421 |
1.21e-04 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 45.23 E-value: 1.21e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 353 QAAVFILIILAATVILSRVlARQITRPVNILQFAASKIGKGDFEPIS-EIKTGDELEFLAHSLNKMAQSL 421
Cdd:PRK10935 154 SLLGLILILTLVFFTVRFT-RRQVVAPLNQLVTASQQIEKGQFDHIPlDTTLPNELGLLAKAFNQMSSEL 222
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
572-653 |
7.26e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 42.70 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 572 NIIRNAIRYTKSegQVTITTINQADSVEVRVADTGIGIPAEEHKMLFRQFFRAtnaiETRNVGTGLGLYIAKNIVDGHKG 651
Cdd:PRK10815 385 NVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRA----DTLRPGQGLGLSVAREITEQYEG 458
|
..
gi 1088191052 652 NI 653
Cdd:PRK10815 459 KI 460
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
566-667 |
7.75e-04 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 39.56 E-value: 7.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKS-EGQVTI---TTINQADS------VEVRVADTGIGIPAEehkmLFRQFFRatnaietRNVGT 635
Cdd:cd16932 7 LQQVLADFLLNAVRFTPSpGGWVEIkvsPTKKQIGDgvhvihLEFRITHPGQGLPEE----LVQEMFE-------ENQWT 75
|
90 100 110
....*....|....*....|....*....|....*
gi 1088191052 636 ---GLGLYIAKNIVDGHKGNIWFIseRDKGTTLFI 667
Cdd:cd16932 76 tqeGLGLSISRKLVKLMNGDVRYL--REAGRSYFL 108
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
565-665 |
2.12e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 38.81 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 565 ALRVLFENIIRNAIRY---TKSEGQVTITTINQADSVEVRVADTGIGIPAEEHKMlfrqfFRATNAIETRNVGtGLGLYI 641
Cdd:pfam13581 31 EVELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPP-----PDLEEPDEDRKEG-GRGLAL 104
|
90 100
....*....|....*....|....
gi 1088191052 642 AKNIVDGHKgniwfISERDKGTTL 665
Cdd:pfam13581 105 IRGLMDDVE-----YTRGGEGNTV 123
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
566-670 |
3.29e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 37.44 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191052 566 LRVLFENIIRNAIRYTKSEGQVTITTINQADS-VEVRVADTGIGIpAEEHKMLFRQFFRATNAIETRNV------GTGLG 638
Cdd:cd16955 6 IQPLVENAIVHGIQEKKGKGVVKISVKKQLKNrLHIAVEDNGIGI-SPKVIERVEQDEMPGNKIGLLNVhqrlklGYGEG 84
|
90 100 110
....*....|....*....|....*....|..
gi 1088191052 639 LYIAknivdghkgniwfiSERDKGTTLFISIP 670
Cdd:cd16955 85 LHIR--------------SRPDPGTLIAFYIP 102
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
576-665 |
3.60e-03 |
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Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 37.25 E-value: 3.60e-03
10 20 30 40 50 60 70 80
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gi 1088191052 576 NAIRYTK---SEGQVTITTINQADSVEVRVADTGIGIPAeehkmlfrqffRATNAIETRNVGTGLGLYIAKNIVDghkgn 652
Cdd:cd16936 11 NAVRHAYrhdGPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADPDAGLREGGRGLALIRALMD----- 74
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90
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gi 1088191052 653 IWFISERDKGTTL 665
Cdd:cd16936 75 EVGYRRTPGGKTV 87
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