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Conserved domains on  [gi|1088191125|gb|OHA50484|]
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MAG: hypothetical protein A3B75_02195 [Candidatus Terrybacteria bacterium RIFCSPHIGHO2_02_FULL_43_14]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hop super family cl34242
Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, ...
 6-93 9.19e-07

Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons];


The actual alignment was detected with superfamily member COG1372:

Pssm-ID: 440983 [Multi-domain]  Cd Length: 866  Bit Score: 46.81  E-value: 9.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   6 CLAENTLIDTPSGAIV----VQNLQQGMEVWTVDISGAR-VPAKIIETVRTPVpstHRIIHLVLNDGRELFVSPGHP--- 77
Cdd:COG1372    98 CLTGDTLVLTADGRLVpigeLVGSGEDVEVLSLDLDTGKlVWAPVTKVFKTGV---KPVYRIRTRSGREIRATPDHPflt 174

                          90
                  ....*....|....*.
gi 1088191125  78 IGDGRTIGDLSVGDVL 93
Cdd:COG1372   175 LSGWKEAGELKPGDRV 190
 
Name Accession Description Interval E-value
Hop COG1372
Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, ...
 6-93 9.19e-07

Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons];


Pssm-ID: 440983 [Multi-domain]  Cd Length: 866  Bit Score: 46.81  E-value: 9.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   6 CLAENTLIDTPSGAIV----VQNLQQGMEVWTVDISGAR-VPAKIIETVRTPVpstHRIIHLVLNDGRELFVSPGHP--- 77
Cdd:COG1372    98 CLTGDTLVLTADGRLVpigeLVGSGEDVEVLSLDLDTGKlVWAPVTKVFKTGV---KPVYRIRTRSGREIRATPDHPflt 174

                          90
                  ....*....|....*.
gi 1088191125  78 IGDGRTIGDLSVGDVL 93
Cdd:COG1372   175 LSGWKEAGELKPGDRV 190
Hint_2 pfam13403
Hint domain; This domain is found in inteins.
 5-78 2.50e-06

Hint domain; This domain is found in inteins.


Pssm-ID: 433179 [Multi-domain]  Cd Length: 147  Bit Score: 44.15  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   5 ICLAENTLIDTPSGAIVVQNLQQGMEVWTVD-------------ISGARVPAKiiETVRtPVpsthRIIHLVLNDG---R 68
Cdd:pfam13403   1 PCFAPGTLIATPRGEVPVETLRPGDLVVTRDggaqpvrwigrrtLSLADLPAP--PALR-PV----RIRAGALGPGvpaR 73

                          90
                  ....*....|
gi 1088191125  69 ELFVSPGHPI 78
Cdd:pfam13403  74 DLLVSPQHRL 83
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 6-129 3.77e-06

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 43.41  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   6 CLAENTLIDTPSGAIV-VQNLQ--QGMEVWTVDISGARVPAKIIETVRTPVPstHRIIHLVLNDGRELFVSPGHPI---- 78
Cdd:cd00081     1 CFTGDTLVLLEDGGRKkIEELVekKGDKVLALDETGKLVFSKVLKVLRRDYE--KKFYKIKTESGREITLTPDHLLfvle 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1088191125  79 -GDGRTI--GDLSVGDVLDGGR-VRIAE-PILYQKEFTYDILPSGeTGLYWANGIL 129
Cdd:cd00081    79 dGELKWVfaSDLKPGDYVLVPVlEKVKEiEEIEYTGGVYDLTVED-NHNFIANGVL 133
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 6-93 5.18e-05

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 39.56  E-value: 5.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125    6 CLAENTLIDTPSGAIV-VQNLQQGMEVWTVDISGARVPAKIIETVRTPvPSTHRIIHLVLNDGRELFVSPGHPI--GDGR 82
Cdd:smart00306   2 CFPGDTLVLTEDGGIKkIEELEEGDKVLALDEGTLKYSPVKVFLVREP-KGEKKFYRIKTENGREITLTPDHLLlvRDGG 80

                           90
                   ....*....|....*.
gi 1088191125   83 TI-----GDLSVGDVL 93
Cdd:smart00306  81 KLvwvfaSELKPGDYV 96
 
Name Accession Description Interval E-value
Hop COG1372
Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, ...
 6-93 9.19e-07

Intein/homing endonuclease [Replication, recombination and repair, Mobilome: prophages, transposons];


Pssm-ID: 440983 [Multi-domain]  Cd Length: 866  Bit Score: 46.81  E-value: 9.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   6 CLAENTLIDTPSGAIV----VQNLQQGMEVWTVDISGAR-VPAKIIETVRTPVpstHRIIHLVLNDGRELFVSPGHP--- 77
Cdd:COG1372    98 CLTGDTLVLTADGRLVpigeLVGSGEDVEVLSLDLDTGKlVWAPVTKVFKTGV---KPVYRIRTRSGREIRATPDHPflt 174

                          90
                  ....*....|....*.
gi 1088191125  78 IGDGRTIGDLSVGDVL 93
Cdd:COG1372   175 LSGWKEAGELKPGDRV 190
Hint_2 pfam13403
Hint domain; This domain is found in inteins.
 5-78 2.50e-06

Hint domain; This domain is found in inteins.


Pssm-ID: 433179 [Multi-domain]  Cd Length: 147  Bit Score: 44.15  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   5 ICLAENTLIDTPSGAIVVQNLQQGMEVWTVD-------------ISGARVPAKiiETVRtPVpsthRIIHLVLNDG---R 68
Cdd:pfam13403   1 PCFAPGTLIATPRGEVPVETLRPGDLVVTRDggaqpvrwigrrtLSLADLPAP--PALR-PV----RIRAGALGPGvpaR 73

                          90
                  ....*....|
gi 1088191125  69 ELFVSPGHPI 78
Cdd:pfam13403  74 DLLVSPQHRL 83
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 6-129 3.77e-06

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 43.41  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125   6 CLAENTLIDTPSGAIV-VQNLQ--QGMEVWTVDISGARVPAKIIETVRTPVPstHRIIHLVLNDGRELFVSPGHPI---- 78
Cdd:cd00081     1 CFTGDTLVLLEDGGRKkIEELVekKGDKVLALDETGKLVFSKVLKVLRRDYE--KKFYKIKTESGREITLTPDHLLfvle 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1088191125  79 -GDGRTI--GDLSVGDVLDGGR-VRIAE-PILYQKEFTYDILPSGeTGLYWANGIL 129
Cdd:cd00081    79 dGELKWVfaSDLKPGDYVLVPVlEKVKEiEEIEYTGGVYDLTVED-NHNFIANGVL 133
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 6-93 5.18e-05

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 39.56  E-value: 5.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088191125    6 CLAENTLIDTPSGAIV-VQNLQQGMEVWTVDISGARVPAKIIETVRTPvPSTHRIIHLVLNDGRELFVSPGHPI--GDGR 82
Cdd:smart00306   2 CFPGDTLVLTEDGGIKkIEELEEGDKVLALDEGTLKYSPVKVFLVREP-KGEKKFYRIKTENGREITLTPDHLLlvRDGG 80

                           90
                   ....*....|....*.
gi 1088191125   83 TI-----GDLSVGDVL 93
Cdd:smart00306  81 KLvwvfaSELKPGDYV 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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