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Conserved domains on  [gi|1113545845|gb|OJY06069|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase [Rhizobiales bacterium 62-17]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 10-216 4.16e-37

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.59  E-value: 4.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  10 FAGRMVQAVVIVFARF---ITATRGRWEGVAPIDEQR--IYFANHVSHGDFVLIWTALPRRlrsrTRPVAGSDYWLKGSL 84
Cdd:COG0204     7 LLRRFRYRLVRLWARLllrLLGVRVRVEGLENLPADGpvLIVANHQSWLDILLLLAALPRP----VRFVAKKELFKIPLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  85 RRFIGRdvFNAVLIDRNRDTRADDPIVQMSDALDAGESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWIDN 164
Cdd:COG0204    83 GWLLRA--LGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGR-LLPFKTGAARLA-LEAGVPIVPVAIDG 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1113545845 165 LNRVMPKGeFVPIPLICTVTFGAALHLG--ETEAKQEFLTRAEAALLALSPKAN 216
Cdd:COG0204   159 TERALPKG-FLPRPGKVTVRIGPPIDPSdlEGEDRRELAERLRAAIEALLAELR 211
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 10-216 4.16e-37

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.59  E-value: 4.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  10 FAGRMVQAVVIVFARF---ITATRGRWEGVAPIDEQR--IYFANHVSHGDFVLIWTALPRRlrsrTRPVAGSDYWLKGSL 84
Cdd:COG0204     7 LLRRFRYRLVRLWARLllrLLGVRVRVEGLENLPADGpvLIVANHQSWLDILLLLAALPRP----VRFVAKKELFKIPLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  85 RRFIGRdvFNAVLIDRNRDTRADDPIVQMSDALDAGESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWIDN 164
Cdd:COG0204    83 GWLLRA--LGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGR-LLPFKTGAARLA-LEAGVPIVPVAIDG 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1113545845 165 LNRVMPKGeFVPIPLICTVTFGAALHLG--ETEAKQEFLTRAEAALLALSPKAN 216
Cdd:COG0204   159 TERALPKG-FLPRPGKVTVRIGPPIDPSdlEGEDRRELAERLRAAIEALLAELR 211
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 32-208 3.23e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 122.76  E-value: 3.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  32 RWEGVAPIDEQR--IYFANHVSHGDFVLIWTALPRRLRsrtrPVAGSDYWLKGSLRRFIGRdvFNAVLIDRNRDTRADDP 109
Cdd:cd07989    13 RVEGLENLPPKGpvIIVANHQSYLDPLVLGAALPRPIR----FVAKKELFKIPFLGWLLRL--LGAIPIDRGNGRSAREA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845 110 IVQMSDALDAGESLIVFPEGTRNTTEaPLLAFKSGLYHLAtARRSVALVPVWIDNLNRVMPKGEFVPIPLICTVTFGAAL 189
Cdd:cd07989    87 LREAIEALKEGESVVIFPEGTRSRDG-ELLPFKSGAFRLA-KEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVRIGEPI 164

                         170
                  ....*....|....*....
gi 1113545845 190 HLGETEAKQEFLTRAEAAL 208
Cdd:cd07989   165 PPEGLELAEEDRKELREKV 183
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 44-165 1.08e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 80.86  E-value: 1.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845   44 IYFANHVSHGDFVLIWTALPRRLRsRTRPVAGSDY---WLKGSLRRFIGrdvfnAVLIDRNRDTRADDPIVQMSDALDAG 120
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLG-RVRFVAKKELfyvPLLGWLLRLLG-----AIFIDRSNGRKARAALREAVELLKEG 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1113545845  121 ESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWIDNL 165
Cdd:smart00563  76 EWLLIFPEGTRSRPGK-LLPFKKGAARLA-LEAGVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 44-162 1.20e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 70.39  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  44 IYFANHVSHGDFVLIWTALPRRLRsRTRPVAGSDY---WLKGSLRRFIGrdvfnAVLIDRNRDTRADDPIVQMSDALDAG 120
Cdd:pfam01553  17 IVVANHQSYLDVLLLSLALYKRGR-PLVFVAKKELfdiPLVGWLMRLLG-----CIFIDRKNRKDAAGTLEYLVELLREG 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1113545845 121 ESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWI 162
Cdd:pfam01553  91 KLVVIFPEGTRSREGE-LLPFKKGAFRLA-IEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 37-160 8.70e-11

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 57.36  E-value: 8.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  37 APIDEQRIYFANHVSHGDFVLIWTALPRRLRSRTR------PVAGSDYWLKGslrrfigrdvfnAVLIDRNrDTRADDPI 110
Cdd:TIGR00530  12 LPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKkelkwiPFFGIMLWLTG------------AIFIDRE-NIRAIATA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1113545845 111 -VQMSDALDAGESLIVFPEGTRNTTEAPlLAFKSGLYHLAtARRSVALVPV 160
Cdd:TIGR00530  79 lKAAIEVLKQGRSIGVFPEGTRSRGRDI-LPFKKGAFHIA-IKAGVPILPV 127
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 32-172 1.79e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 47.03  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  32 RWEGVAPIDEQRIYFANHVSHGD-FVLIWTALPRRLRSRTR----PVAGSDYWLKG--SLRRFigrdvfnavlidrnrDT 104
Cdd:PLN02901   41 GLENLPSPDEPAVYVSNHQSFLDiYTLFHLGRPFKFISKTSifliPIIGWAMYMTGhiPLKRM---------------DR 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545845 105 RAD-DPIVQMSDALDAGESLIVFPEGTRnTTEAPLLAFKSGLYHLAtARRSVALVPVWIDNLNRVMPKG 172
Cdd:PLN02901  106 RSQlECLKRCMELLKKGASVFFFPEGTR-SKDGKLAAFKKGAFSVA-AKTGVPVVPITLVGTGKIMPNG 172
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 10-216 4.16e-37

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.59  E-value: 4.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  10 FAGRMVQAVVIVFARF---ITATRGRWEGVAPIDEQR--IYFANHVSHGDFVLIWTALPRRlrsrTRPVAGSDYWLKGSL 84
Cdd:COG0204     7 LLRRFRYRLVRLWARLllrLLGVRVRVEGLENLPADGpvLIVANHQSWLDILLLLAALPRP----VRFVAKKELFKIPLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  85 RRFIGRdvFNAVLIDRNRDTRADDPIVQMSDALDAGESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWIDN 164
Cdd:COG0204    83 GWLLRA--LGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGR-LLPFKTGAARLA-LEAGVPIVPVAIDG 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1113545845 165 LNRVMPKGeFVPIPLICTVTFGAALHLG--ETEAKQEFLTRAEAALLALSPKAN 216
Cdd:COG0204   159 TERALPKG-FLPRPGKVTVRIGPPIDPSdlEGEDRRELAERLRAAIEALLAELR 211
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 32-208 3.23e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 122.76  E-value: 3.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  32 RWEGVAPIDEQR--IYFANHVSHGDFVLIWTALPRRLRsrtrPVAGSDYWLKGSLRRFIGRdvFNAVLIDRNRDTRADDP 109
Cdd:cd07989    13 RVEGLENLPPKGpvIIVANHQSYLDPLVLGAALPRPIR----FVAKKELFKIPFLGWLLRL--LGAIPIDRGNGRSAREA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845 110 IVQMSDALDAGESLIVFPEGTRNTTEaPLLAFKSGLYHLAtARRSVALVPVWIDNLNRVMPKGEFVPIPLICTVTFGAAL 189
Cdd:cd07989    87 LREAIEALKEGESVVIFPEGTRSRDG-ELLPFKSGAFRLA-KEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVRIGEPI 164

                         170
                  ....*....|....*....
gi 1113545845 190 HLGETEAKQEFLTRAEAAL 208
Cdd:cd07989   165 PPEGLELAEEDRKELREKV 183
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 44-165 1.08e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 80.86  E-value: 1.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845   44 IYFANHVSHGDFVLIWTALPRRLRsRTRPVAGSDY---WLKGSLRRFIGrdvfnAVLIDRNRDTRADDPIVQMSDALDAG 120
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLG-RVRFVAKKELfyvPLLGWLLRLLG-----AIFIDRSNGRKARAALREAVELLKEG 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1113545845  121 ESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWIDNL 165
Cdd:smart00563  76 EWLLIFPEGTRSRPGK-LLPFKKGAARLA-LEAGVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 44-162 1.20e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 70.39  E-value: 1.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  44 IYFANHVSHGDFVLIWTALPRRLRsRTRPVAGSDY---WLKGSLRRFIGrdvfnAVLIDRNRDTRADDPIVQMSDALDAG 120
Cdd:pfam01553  17 IVVANHQSYLDVLLLSLALYKRGR-PLVFVAKKELfdiPLVGWLMRLLG-----CIFIDRKNRKDAAGTLEYLVELLREG 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1113545845 121 ESLIVFPEGTRNTTEApLLAFKSGLYHLAtARRSVALVPVWI 162
Cdd:pfam01553  91 KLVVIFPEGTRSREGE-LLPFKKGAFRLA-IEAGVPIVPVAI 130
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 21-211 1.68e-11

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 60.89  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  21 VFARFITATRGRWEGVAPIDEQR--IYFANHVSHGDFVLIWTALPRRLRsRTRPVAGSDywLKGSLRRFIGRdvFNAVLI 98
Cdd:cd06551     4 LLLNFFGFVRLEVKGPPPPPGGGpvLFVSNHSSWWDGLILFLLLERGLR-RDVYGLMDE--ELLERYPFFTR--LGAFSV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  99 DRNRDTRADDPIVQMSDAL-DAGESLIVFPEGTRNTTEAPLLAFKSGLYHLAtARRSVALVPVWIDNLNRVM-PKGEFvp 176
Cdd:cd06551    79 DRDSPRSAAKSLKYVARLLsKPGSVVWIFPEGTRTRRDKRPLQFKPGVAHLA-EKAGVPIVPVALRYTFELFeQFPEI-- 155

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1113545845 177 iplicTVTFGAALHLGETEAKQEFLTRAEAALLAL 211
Cdd:cd06551   156 -----FVRIGPPIPYAETALGEELAAELANRLTRL 185
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 37-160 8.70e-11

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 57.36  E-value: 8.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  37 APIDEQRIYFANHVSHGDFVLIWTALPRRLRSRTR------PVAGSDYWLKGslrrfigrdvfnAVLIDRNrDTRADDPI 110
Cdd:TIGR00530  12 LPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKkelkwiPFFGIMLWLTG------------AIFIDRE-NIRAIATA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1113545845 111 -VQMSDALDAGESLIVFPEGTRNTTEAPlLAFKSGLYHLAtARRSVALVPV 160
Cdd:TIGR00530  79 lKAAIEVLKQGRSIGVFPEGTRSRGRDI-LPFKKGAFHIA-IKAGVPILPV 127
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 32-172 1.79e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 47.03  E-value: 1.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  32 RWEGVAPIDEQRIYFANHVSHGD-FVLIWTALPRRLRSRTR----PVAGSDYWLKG--SLRRFigrdvfnavlidrnrDT 104
Cdd:PLN02901   41 GLENLPSPDEPAVYVSNHQSFLDiYTLFHLGRPFKFISKTSifliPIIGWAMYMTGhiPLKRM---------------DR 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545845 105 RAD-DPIVQMSDALDAGESLIVFPEGTRnTTEAPLLAFKSGLYHLAtARRSVALVPVWIDNLNRVMPKG 172
Cdd:PLN02901  106 RSQlECLKRCMELLKKGASVFFFPEGTR-SKDGKLAAFKKGAFSVA-AKTGVPVVPITLVGTGKIMPNG 172
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 47-199 2.97e-06

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 47.23  E-value: 2.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845   47 ANHVSHGDFVLIWTALPRRLRSrtrpVAGSDYWLKGSLRRFIgrDVFNAVLIDrNRDTRAddpIVQ-MSDALDAGESLIV 125
Cdd:PRK08633   447 GNHVSWIDWALLQAASPRPIRF----VMERSIYEKWYLKWFF--KLFGVIPIS-SGGSKE---SLEfIRKALDDGEVVCI 516

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  126 FPEG--TRNtteAPLLAFKSGlYHLATARRSVALVPVWIDNL-----NRVmpKGEFVP-----IPLICTVTFGAALHLGE 193
Cdd:PRK08633   517 FPEGaiTRN---GQLNEFKRG-FELIVKGTDVPIIPFYIRGLwgsifSRA--SGKFLWrwptrIPYPVTVAFGKPMPAHS 590


                   ....*...
gi 1113545845  194 T--EAKQE 199
Cdd:PRK08633   591 TahEVKQA 598
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 44-135 4.35e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 45.69  E-value: 4.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  44 IYFANHVSHGDFVLIWTALPRR-LRSRTRpvagsdYWLKGSLR--------RFIGRDVFnavlIDRNrdtRADDpIVQMS 114
Cdd:cd07990    27 LIISNHRSEVDWLVLWMLADRFgRLGRLK------IVLKDSLKypplggwgWQLGEFIF----LKRK---WEKD-EKTIK 92

                          90       100
                  ....*....|....*....|....*..
gi 1113545845 115 DALD------AGESLIVFPEGTRNTTE 135
Cdd:cd07990    93 RQLKrlkdspEPFWLLIFPEGTRFTEE 119
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 44-164 1.07e-05

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 45.00  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  44 IYFANHVSHGDFVLIWTAL-PRRLRSRTR-----PVAGSDYWLKGSLrrfigrdvfnavLIDRNRDTRADDPIVQMSDAL 117
Cdd:PRK15018   68 IYIANHQNNYDMVTASNIVqPPTVTVGKKsllwiPFFGQLYWLTGNL------------LIDRNNRTKAHGTIAEVVNHF 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1113545845 118 DAGE-SLIVFPEGTRNTTEApLLAFKSGLYHLATArRSVALVPVWIDN 164
Cdd:PRK15018  136 KKRRiSIWMFPEGTRSRGRG-LLPFKTGAFHAAIA-AGVPIIPVCVST 181
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 44-160 3.39e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 40.32  E-value: 3.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  44 IYFANHvsHGDFV---LIWTALPRRLRsrtrpvagsdYWLKGSL--RRFIGR--DVFNAVLIDRNRDTRA--------DD 108
Cdd:cd07992    31 IFLGNH--PNALIdplLLAATLRRPVR----------FLAKADLfkNPLIGWllESFGAIPVYRPKDLARggigkisnAA 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1113545845 109 PIVQMSDALDAGESLIVFPEGTrNTTEAPLLAFKSGLYHLATA-----RRSVALVPV 160
Cdd:cd07992    99 VFDAVGEALKAGGAIGIFPEGG-SHDRPRLLPLKAGAARMALEaleagQKDVKIVPV 154
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 47-169 7.09e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 38.74  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545845  47 ANHVSHGDFVLiwtALPRRLRSRTRP-VAGSDYWLKGSLR---RFIGrdvfnAVLIDRnrdTRADDPIVQMSDALDAGE- 121
Cdd:cd07988    27 APHTSNWDFVL---GLLAAFALGLKIsFLGKHSLFKPPLGpfmRWLG-----GIPVDR---SRAGGLVEQVVEEFRRREe 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1113545845 122 -SLIVFPEGTRNTTEApllaFKSGLYHLATArRSVALVPVWIDNLNRVM 169
Cdd:cd07988    96 fVLAIAPEGTRSKVDK----WKTGFYHIARG-AGVPILLVYLDYKRKTV 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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