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Conserved domains on  [gi|1113545848|gb|OJY06072|]
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MarR family transcriptional regulator [Rhizobiales bacterium 62-17]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-122 3.17e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.85  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848  13 FAGTDLSPSAVHALIEI-EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDV-KEEAGEDARVKILSLTARGKKQVAAIH 90
Cdd:COG1846    31 LAELGLTPAQFRVLAALaEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVeREPDPEDRRAVLVRLTEKGRALLEEAR 110

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1113545848  91 AFARTQVADALGRMKSDQGRTVLEGLRLYTDA 122
Cdd:COG1846   111 PALEALLAELLAGLSEEELEALLRLLRRLAEN 142
ArgA super family cl43364
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 187-285 1.92e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


The actual alignment was detected with superfamily member COG1246:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 40.75  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848 187 LETPRNAIWAALQDGQIIGSIAIDGEDlnrknagSNIAHLRWFIVDDGVRGGGVGRKLLSAALAFVDEKAFSETHLWTFa 266
Cdd:COG1246    23 LEEEIGEFWVAEEDGEIVGCAALHPLD-------EDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTT- 94

                          90
                  ....*....|....*....
gi 1113545848 267 glSAARRLYEAHGFVCVEE 285
Cdd:COG1246    95 --SAAIHFYEKLGFEEIDK 111
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-122 3.17e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.85  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848  13 FAGTDLSPSAVHALIEI-EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDV-KEEAGEDARVKILSLTARGKKQVAAIH 90
Cdd:COG1846    31 LAELGLTPAQFRVLAALaEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVeREPDPEDRRAVLVRLTEKGRALLEEAR 110

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1113545848  91 AFARTQVADALGRMKSDQGRTVLEGLRLYTDA 122
Cdd:COG1846   111 PALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
13-108 3.61e-10

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 56.06  E-value: 3.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848   13 FAGTDLSPSAVHALIEI-EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEAG-EDARVKILSLTARGKKQVAAIH 90
Cdd:smart00347   3 LKPLGLTPTQFLVLRILyEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*...
gi 1113545848   91 AFARTQVADALGRMKSDQ 108
Cdd:smart00347  83 EARSETLAELLAGLTAEE 100
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 16-72 2.21e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.20  E-value: 2.21e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545848  16 TDLSPSAVHALIEIEK-GGVTARDLGARLRLEKSSVSRMLRKLVESGDV-KEEAGEDAR 72
Cdd:pfam12802   1 LGLTPAQFRVLLALARnPGLTVAELARRLGISKQTVSRLVKRLEAKGLVeREPSPADRR 59
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 187-285 1.92e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 40.75  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848 187 LETPRNAIWAALQDGQIIGSIAIDGEDlnrknagSNIAHLRWFIVDDGVRGGGVGRKLLSAALAFVDEKAFSETHLWTFa 266
Cdd:COG1246    23 LEEEIGEFWVAEEDGEIVGCAALHPLD-------EDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTT- 94

                          90
                  ....*....|....*....
gi 1113545848 267 glSAARRLYEAHGFVCVEE 285
Cdd:COG1246    95 --SAAIHFYEKLGFEEIDK 111
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-81 9.60e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 9.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1113545848  26 LIEIEKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEagEDARVKILSLTAR 81
Cdd:cd00090    13 LRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR--REGRRVYYSLTDA 66
PRK03902 PRK03902
transcriptional regulator MntR;
26-84 3.03e-03

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 37.28  E-value: 3.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545848  26 LIEiEKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEagedaRVKILSLTARGKK 84
Cdd:PRK03902   16 LIE-EKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYE-----KYRGLVLTPKGKK 68
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
13-122 3.17e-16

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 73.85  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848  13 FAGTDLSPSAVHALIEI-EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDV-KEEAGEDARVKILSLTARGKKQVAAIH 90
Cdd:COG1846    31 LAELGLTPAQFRVLAALaEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVeREPDPEDRRAVLVRLTEKGRALLEEAR 110

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1113545848  91 AFARTQVADALGRMKSDQGRTVLEGLRLYTDA 122
Cdd:COG1846   111 PALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
13-108 3.61e-10

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 56.06  E-value: 3.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848   13 FAGTDLSPSAVHALIEI-EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEAG-EDARVKILSLTARGKKQVAAIH 90
Cdd:smart00347   3 LKPLGLTPTQFLVLRILyEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSpEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*...
gi 1113545848   91 AFARTQVADALGRMKSDQ 108
Cdd:smart00347  83 EARSETLAELLAGLTAEE 100
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 16-72 2.21e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 47.20  E-value: 2.21e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545848  16 TDLSPSAVHALIEIEK-GGVTARDLGARLRLEKSSVSRMLRKLVESGDV-KEEAGEDAR 72
Cdd:pfam12802   1 LGLTPAQFRVLLALARnPGLTVAELARRLGISKQTVSRLVKRLEAKGLVeREPSPADRR 59
HTH_27 pfam13463
Winged helix DNA-binding domain;
18-82 4.78e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 46.51  E-value: 4.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1113545848  18 LSPSAVHAL--IEIEKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEAGE-DARVKILSLTARG 82
Cdd:pfam13463   1 LTRLEALILhnIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEeDGRETRVRLTAKG 68
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
16-89 1.12e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 44.04  E-value: 1.12e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545848  16 TDLSPSAVHALIEI-----EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEagedaRVKILSLTARGKKQVAAI 89
Cdd:COG1321     2 MMLSESEEDYLKAIyelseEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYE-----PYGGITLTEEGRELALRI 75
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 18-74 3.70e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.61  E-value: 3.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545848  18 LSPSAVHALIEI-EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEAG-EDARVK 74
Cdd:pfam01047   1 LTLTQFHILRILyEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSpEDRREV 59
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 187-285 1.92e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 40.75  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1113545848 187 LETPRNAIWAALQDGQIIGSIAIDGEDlnrknagSNIAHLRWFIVDDGVRGGGVGRKLLSAALAFVDEKAFSETHLWTFa 266
Cdd:COG1246    23 LEEEIGEFWVAEEDGEIVGCAALHPLD-------EDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTT- 94

                          90
                  ....*....|....*....
gi 1113545848 267 glSAARRLYEAHGFVCVEE 285
Cdd:COG1246    95 --SAAIHFYEKLGFEEIDK 111
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-81 9.60e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 9.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1113545848  26 LIEIEKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEagEDARVKILSLTAR 81
Cdd:cd00090    13 LRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR--REGRRVYYSLTDA 66
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
17-66 2.00e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 37.64  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1113545848  17 DLSPSAVHALIEI--EKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEE 66
Cdd:COG3355    24 GLSETDAEVYLILleNGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLVERE 75
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 243-285 2.28e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 36.56  E-value: 2.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1113545848 243 KLLSAALAFVDEKAFSETHLWTFAGLSAARRLYEAHGFVCVEE 285
Cdd:COG0456    33 ALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGE 75
PRK03902 PRK03902
transcriptional regulator MntR;
26-84 3.03e-03

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 37.28  E-value: 3.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1113545848  26 LIEiEKGGVTARDLGARLRLEKSSVSRMLRKLVESGDVKEEagedaRVKILSLTARGKK 84
Cdd:PRK03902   16 LIE-EKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYE-----KYRGLVLTPKGKK 68
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 243-286 6.51e-03

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 36.18  E-value: 6.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1113545848 243 KLLSAALAFVDEKAFSETHLWTFAGLSAARRLYEAHGFVCVEEW 286
Cdd:COG0454    78 ALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERY 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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