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Conserved domains on  [gi|1125100881|gb|OLA62884|]
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succinate--CoA ligase subunit alpha [Firmicutes bacterium CAG:272_52_7]

Protein Classification

SucD family protein( domain architecture ID 11414657)

SucD family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-288 8.56e-171

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 473.78  E-value: 8.56e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   2 SILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAG 81
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  82 VYEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYET 161
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 162 VFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAPK 241
Cdd:COG0074   161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1125100881 242 GKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:COG0074   241 GKRMGHAGAIISG-GKGTAESKIEALEAAGVPVAESPSEIGELLKKA 286
 
Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-288 8.56e-171

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 473.78  E-value: 8.56e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   2 SILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAG 81
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  82 VYEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYET 161
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 162 VFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAPK 241
Cdd:COG0074   161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1125100881 242 GKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:COG0074   241 GKRMGHAGAIISG-GKGTAESKIEALEAAGVPVAESPSEIGELLKKA 286
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-288 9.98e-150

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 420.73  E-value: 9.98e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   1 MSILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAA 80
Cdd:PRK05678    1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  81 GVYEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYE 160
Cdd:PRK05678   81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 161 TVFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAP 240
Cdd:PRK05678  161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1125100881 241 KGKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:PRK05678  241 PGKRMGHAGAIISG-GKGTAEEKKEALEAAGVKVARTPSEIGELLKEV 287
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-288 1.23e-136

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 387.54  E-value: 1.23e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   3 ILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAGV 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  83 YEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYETV 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 163 FMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAPKG 242
Cdd:TIGR01019 161 HQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMSKPVVGFIAGATAPPG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1125100881 243 KSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:TIGR01019 241 KRMGHAGAIISG-GKGTAESKIEALEAAGVTVVKSPSDIGELLAEI 285
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 6.95e-27

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 100.74  E-value: 6.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   6 DENTRLIIQGITGR---EGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAGV 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiqGLNYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1125100881  83 YEALDAGIKTVMTIAEH 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 4-100 6.87e-26

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 98.35  E-value: 6.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881    4 LVDENTRLIIQGITGREGTFHCEQM---LQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAA 80
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 1125100881   81 GVYEALDAGIKTVMTIAEHV 100
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
 
Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-288 8.56e-171

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 473.78  E-value: 8.56e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   2 SILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAG 81
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  82 VYEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYET 161
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMPGHIFKPGRVGIVSRSGTLTYEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 162 VFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAPK 241
Cdd:COG0074   161 VWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKENMTKPVVAYIAGRTAPP 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1125100881 242 GKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:COG0074   241 GKRMGHAGAIISG-GKGTAESKIEALEAAGVPVAESPSEIGELLKKA 286
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-288 9.98e-150

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 420.73  E-value: 9.98e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   1 MSILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAA 80
Cdd:PRK05678    1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  81 GVYEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYE 160
Cdd:PRK05678   81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMPGHIHKKGRVGVVSRSGTLTYE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 161 TVFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAP 240
Cdd:PRK05678  161 AVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANVTKPVVGYIAGVTAP 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1125100881 241 KGKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:PRK05678  241 PGKRMGHAGAIISG-GKGTAEEKKEALEAAGVKVARTPSEIGELLKEV 287
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-288 1.23e-136

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 387.54  E-value: 1.23e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   3 ILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAGV 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  83 YEALDAGIKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYETV 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMPGHIHKPGNVGIVSRSGTLTYEAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 163 FMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVTKPVVALIAGKNAPKG 242
Cdd:TIGR01019 161 HQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNMSKPVVGFIAGATAPPG 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1125100881 243 KSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGIVDILKTL 288
Cdd:TIGR01019 241 KRMGHAGAIISG-GKGTAESKIEALEAAGVTVVKSPSDIGELLAEI 285
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 3-277 1.60e-110

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 322.43  E-value: 1.60e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   3 ILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGEN--VFGVPVFNTVREAMEATDANASVIFVPALHTAA 80
Cdd:PTZ00187   24 VWVNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTThlKHGLPVFATVKEAKKATGADASVIYVPPPHAAS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  81 GVYEALDAGIKTVMTIAEHVPVHDMMRVYH-IAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCY 159
Cdd:PTZ00187  104 AIIEAIEAEIPLVVCITEGIPQHDMVKVKHaLLSQNKTRLIGPNCPGIIKPGECKIGIMPGHIHKKGKIGIVSRSGTLTY 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 160 ETVFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVT-KPVVALIAGKN 238
Cdd:PTZ00187  184 EAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNNPIkKPVVSFIAGIT 263

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1125100881 239 APKGKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAET 277
Cdd:PTZ00187  264 APPGRRMGHAGAIISG-GKGTAPGKIEALEAAGVRVVKS 301
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 2-281 8.10e-102

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 299.58  E-value: 8.10e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   2 SILVDENTRLIIQGITGREGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAG 81
Cdd:PLN00125    6 AVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPFAAAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  82 VYEALDAGIKTVMTIAEHVPVHDMMRVYH-IAREKGARVIGPNSFGVISPGKSKAGFMAHRIFLPGHVGLMSRSATNCYE 160
Cdd:PLN00125   86 ILEAMEAELDLVVCITEGIPQHDMVRVKAaLNRQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGRIGIVSRSGTLTYE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 161 TVFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKNHVT-KPVVALIAGKNA 239
Cdd:PLN00125  166 AVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESGTeKPVVAFIAGLTA 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1125100881 240 PKGKSMGHAGAIVAAdGTGSAENKEKALRAAGVHIAETTTGI 281
Cdd:PLN00125  246 PPGRRMGHAGAIVSG-GKGTAQDKIKALREAGVTVVESPAKI 286
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 33-286 3.82e-31

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 121.85  E-value: 3.82e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  33 TKVVAG-VTPGKGG--ENVFG-----VPVFNTVREAMEA-TDANASVIFVPALHTAAGVYEALDAG-IKTVMTIAEHVPV 102
Cdd:PLN02522   37 TPSVAGiINPGSEGfqKLFFGqeeiaIPVHGSIEAACKAhPTADVFINFASFRSAAASSMEALKQPtIRVVAIIAEGVPE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 103 HDMMRVYHIAREKGARVIGPNSFGVISPGKSKAG--------FMAHRIFLPGHVGLMSRSATNCYETVFMMTNAGIGQST 174
Cdd:PLN02522  117 SDTKQLIAYARANNKVVIGPATVGGIQAGAFKIGdtagtldnIIQCKLYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYE 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 175 CVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIGGNEEELAAEYIKN-HVTKPVVALIAGKNAPKGKS---MGHAGA 250
Cdd:PLN02522  197 GIAIGGDVFPGSTLSDHVLRFNNIPQIKMIVVLGELGGRDEYSLVEALKQgKVSKPVVAWVSGTCARLFKSevqFGHAGA 276

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1125100881 251 IVAADgTGSAENKEKALRAAGVHIAETTTGIVDILK 286
Cdd:PLN02522  277 KSGGD-MESAQAKNKALKDAGAIVPTSFEALEAAIK 311
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 6.95e-27

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 100.74  E-value: 6.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881   6 DENTRLIIQGITGR---EGTFHCEQMLQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAAGV 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiqGLNYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1125100881  83 YEALDAGIKTVMTIAEH 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 4-100 6.87e-26

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 98.35  E-value: 6.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881    4 LVDENTRLIIQGITGREGTFHCEQM---LQYGTKVVAGVTPGKGGENVFGVPVFNTVREAMEATDANASVIFVPALHTAA 80
Cdd:smart00881   1 LLNPNTSVAVVGASGNLGSFGLAVMrnlLEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPD 80

                           90       100
                   ....*....|....*....|
gi 1125100881   81 GVYEALDAGIKTVMTIAEHV 100
Cdd:smart00881  81 AIDEAIEAGIKGIVVITEGI 100
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 151-272 4.36e-24

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 94.25  E-value: 4.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 151 MSRSATNCYETVFMMTNAGIGQSTCVGVGGDMIPGSTFTDLLPLFEADPETKAVVIIGEIG-GNEEELAAEYIKNH---- 225
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGyGACEDPAGGLLKAIkear 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1125100881 226 -VTKPVVALIAGKNAPKGKSMGHAGAIVAAdGTGSAENKEKALRAAGV 272
Cdd:pfam00549  81 aRELPVVARVCGTEADPQGRSGQAKALAES-GVLIASSNNQALRAAGA 127
PatZN COG1042
Acyl-CoA synthetase (NDP forming) [Energy production and conversion];
45-288 6.98e-17

Acyl-CoA synthetase (NDP forming) [Energy production and conversion];


Pssm-ID: 440664 [Multi-domain]  Cd Length: 708  Bit Score: 80.55  E-value: 6.98e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  45 GENVFGVPVFNTVREAMEATD-AnasVIFVPALHTAAGVYEALDAGIKTVMTIA--------EHVPVHDmmRVYHIAREK 115
Cdd:COG1042    51 YDEVLGLPCYPSVADLPEPPDlA---VIAVPAETVPDVVEECGEKGVKAAVVISagfaetgeEGAALEQ--ELLEIARRY 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 116 GARVIGPNSFGVISPG-KSKAGFmAHRIFLPGHVGLMSRSATNCYETVFMMTNAGIGQSTCVGVgGDMIpGSTFTDLLPL 194
Cdd:COG1042   126 GMRLLGPNCLGLINPAtGLNATF-APVPPLPGNIALVSQSGALGTAILDWAAARGIGFSHFVSL-GNEA-DVDFADLLDY 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 195 FEADPETKAVVIIgeiggneeelaAEYIKN-----------HVTKPVVALIAGKNApKGKSMG--HAGAIVAADGTGSAe 261
Cdd:COG1042   203 LADDPDTRVILLY-----------LEGIRDgrrflsaaraaARGKPVVVLKSGRSE-AGARAAasHTGALAGSDAVYDA- 269

                         250       260
                  ....*....|....*....|....*..
gi 1125100881 262 nkekALRAAGVHIAETTTGIVDILKTL 288
Cdd:COG1042   270 ----AFRRAGVIRVDDLEELFDAAEAL 292
PRK06091 PRK06091
membrane protein FdrA; Validated
 54-274 1.34e-10

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 61.60  E-value: 1.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  54 FNTVRE---AME-ATDANASVIFVPALHTAAGVYEALDAGiKTVMTIAEHVPVHDMMRVYHIAREKGARVIGPNSfGVIS 129
Cdd:PRK06091  102 LTQVRRwdsACQkLPDANLALISVAGEYAAELAEQALDRN-LNVMMFSDNVTLEDEIRLKTRAREKGLLVMGPDC-GTAM 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 130 PGKSKAGFMahRIFLPGHVGLMSRSATNCYETVFMMTNAGIGQSTCVGVGG-DM---IPGSTFTDLLPLFEADPETKAVV 205
Cdd:PRK06091  180 IAGTPLAFA--NVMPEGNIGVIGASGTGIQELCSQIALAGEGITHAIGLGGrDLsaeVGGISALTALEMLSADEKSEVIA 257

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125100881 206 IIGEIGGNE-EELAAEYIKNHvTKPVVALIAGKNAPKGK--SMGHA-----GAIVAADGTGSAENKEKALRAAGVHI 274
Cdd:PRK06091  258 FVSKPPAEAvRLKIINAMKAT-GKPVVALFLGYTPAVARdeNVWFAstldeAARLACLLSRVTAQRNAILPVSQGFI 333
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 145-288 8.51e-10

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 55.94  E-value: 8.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 145 PGHVGLMSRSATNCYETVFMMTNAGIGQSTCVGVGG--DMipgsTFTDLLPLFEADPETKAVVIIGEIGGNEEEL--AAE 220
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLGNeaDV----DFADLLEYLADDPETRVILLYLEGIRDGRRFlrAAR 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881 221 YIKNHvtKPVVALIAGKnAPKGK--SMGHAGAIVAADGTGSAenkekALRAAGVHIAETTTGIVDILKTL 288
Cdd:pfam13607  77 RAARR--KPVVVLKAGR-SEAGAraAASHTGALAGSDAVYDA-----AFRQAGVIRVDDLEELFDAAEAL 138
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 26-130 2.00e-07

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 48.69  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125100881  26 EQMLQYGTKVVAgVTPGKggENVFGVPVFNTVREAMEATDAnaSVIFVPALHTAAGVYEALDAGIKTVMTIAEhvPVHDm 105
Cdd:pfam13380  21 RYLLEHGYPVIP-VNPKA--KEILGEPVYPSLADPPEPVDL--VDVFRPPEAVPEIVEEALALGAKAVWLQPG--IENE- 92

                          90       100
                  ....*....|....*....|....*
gi 1125100881 106 mRVYHIAREKGARVIGPNSFGVISP 130
Cdd:pfam13380  93 -EAAAIARAAGIRVVGDRCLGVEHP 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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