dihydropteroate synthase-related protein; This protein has been found so far only in the ...
12-444
1.66e-50
dihydropteroate synthase-related protein; This protein has been found so far only in the Archaea, and in particular in those archaea that lack a bacterial-type dihydropteroate synthase. The central region of this protein shows considerable homology to the amino-terminal half of dihydropteroate synthases, while the carboxyl-terminal region shows homology to the small, uncharacterized protein slr0651 of Synechocystis PCC6803. [Unknown function, General]
The actual alignment was detected with superfamily member TIGR00284:
Pssm-ID: 272997 [Multi-domain] Cd Length: 499 Bit Score: 179.34 E-value: 1.66e-50
dihydropteroate synthase-related protein; This protein has been found so far only in the ...
12-444
1.66e-50
dihydropteroate synthase-related protein; This protein has been found so far only in the Archaea, and in particular in those archaea that lack a bacterial-type dihydropteroate synthase. The central region of this protein shows considerable homology to the amino-terminal half of dihydropteroate synthases, while the carboxyl-terminal region shows homology to the small, uncharacterized protein slr0651 of Synechocystis PCC6803. [Unknown function, General]
Pssm-ID: 272997 [Multi-domain] Cd Length: 499 Bit Score: 179.34 E-value: 1.66e-50
Family of unknown function (DUF6513); This presumed domain is functionally uncharacterized. ...
13-95
2.92e-21
Family of unknown function (DUF6513); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is typically between 75 and 86 amino acids in length.
Pssm-ID: 437955 Cd Length: 86 Bit Score: 87.73 E-value: 2.92e-21
Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and ...
120-319
1.18e-14
Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS. Cobalamin-dependent methyltransferases catalyze the transfer of a methyl group via a methyl- cob(III)amide intermediate. These include MeTr, a functional heterodimer, and the folate binding domain of MetH.
Pssm-ID: 238242 [Multi-domain] Cd Length: 258 Bit Score: 73.85 E-value: 1.18e-14
dihydropteroate synthase-related protein; This protein has been found so far only in the ...
12-444
1.66e-50
dihydropteroate synthase-related protein; This protein has been found so far only in the Archaea, and in particular in those archaea that lack a bacterial-type dihydropteroate synthase. The central region of this protein shows considerable homology to the amino-terminal half of dihydropteroate synthases, while the carboxyl-terminal region shows homology to the small, uncharacterized protein slr0651 of Synechocystis PCC6803. [Unknown function, General]
Pssm-ID: 272997 [Multi-domain] Cd Length: 499 Bit Score: 179.34 E-value: 1.66e-50
Family of unknown function (DUF6513); This presumed domain is functionally uncharacterized. ...
13-95
2.92e-21
Family of unknown function (DUF6513); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and archaea, and is typically between 75 and 86 amino acids in length.
Pssm-ID: 437955 Cd Length: 86 Bit Score: 87.73 E-value: 2.92e-21
Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and ...
120-319
1.18e-14
Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS. Cobalamin-dependent methyltransferases catalyze the transfer of a methyl group via a methyl- cob(III)amide intermediate. These include MeTr, a functional heterodimer, and the folate binding domain of MetH.
Pssm-ID: 238242 [Multi-domain] Cd Length: 258 Bit Score: 73.85 E-value: 1.18e-14
Pterin binding enzyme; This family includes a variety of pterin binding enzymes that all adopt ...
144-312
1.04e-04
Pterin binding enzyme; This family includes a variety of pterin binding enzymes that all adopt a TIM barrel fold. The family includes dihydropteroate synthase EC:2.5.1.15 as well as a group methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) that catalyzes a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation. It transfers the N5-methyl group from methyltetrahydrofolate (CH3-H4folate) to a cob(I)amide centre in another protein, the corrinoid iron-sulfur protein. MeTr is a member of a family of proteins that includes methionine synthase and methanogenic enzymes that activate the methyl group of methyltetra-hydromethano(or -sarcino)pterin.
Pssm-ID: 395651 [Multi-domain] Cd Length: 243 Bit Score: 43.81 E-value: 1.04e-04
Domain of unknown function (DUF4346); This family of proteins is found in bacteria, archaea ...
417-440
2.55e-04
Domain of unknown function (DUF4346); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 127 and 502 amino acids in length. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and Swiss:Q57571 has been shown not to possess dihydropteroate synthase activity.
Pssm-ID: 405014 Cd Length: 118 Bit Score: 40.63 E-value: 2.55e-04
DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional ...
144-317
1.50e-03
DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.
Pssm-ID: 238380 Cd Length: 257 Bit Score: 40.28 E-value: 1.50e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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