NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1125431682|gb|OLD60684|]
View 

hypothetical protein AUF60_00145 [Gemmatimonadetes bacterium 13_1_20CM_69_28]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 11445445)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
1-245 1.94e-21

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


:

Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 89.31  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGFKDWGFFPYvAERLARAGLGVVSFNFSGAGvgedsatfdepeRFGHNTYTKELRDLDIVLDALtKGAFGFQPS 80
Cdd:COG1506    28 YVHGGPGSRDDSFLPL-AQALASRGYAVLAPDYRGYG------------ESAGDWGGDEVDDVLAAIDYL-AARPYVDPD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  81 AYGLFGHSAGGGVAVLRAAQD-ERVRALVTWAAVARFGRLiaplidelrrtgtARVVSPRTGEELPLYRDISDDLDAHga 159
Cdd:COG1506    94 RIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDLRSY-------------YGTTREYTERLMGGPWEDPEAYAAR-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 160 aggglDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGA--GERQLFLVDGAGHGFgaghpwtgSNPALEQVVRRT 237
Cdd:COG1506   159 -----SPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagKPVELLVYPGEGHGF--------SGAGAPDYLERI 225


                  ....*...
gi 1125431682 238 LDWFARHL 245
Cdd:COG1506   226 LDFLDRHL 233
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
1-245 1.94e-21

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 89.31  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGFKDWGFFPYvAERLARAGLGVVSFNFSGAGvgedsatfdepeRFGHNTYTKELRDLDIVLDALtKGAFGFQPS 80
Cdd:COG1506    28 YVHGGPGSRDDSFLPL-AQALASRGYAVLAPDYRGYG------------ESAGDWGGDEVDDVLAAIDYL-AARPYVDPD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  81 AYGLFGHSAGGGVAVLRAAQD-ERVRALVTWAAVARFGRLiaplidelrrtgtARVVSPRTGEELPLYRDISDDLDAHga 159
Cdd:COG1506    94 RIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDLRSY-------------YGTTREYTERLMGGPWEDPEAYAAR-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 160 aggglDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGA--GERQLFLVDGAGHGFgaghpwtgSNPALEQVVRRT 237
Cdd:COG1506   159 -----SPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagKPVELLVYPGEGHGF--------SGAGAPDYLERI 225


                  ....*...
gi 1125431682 238 LDWFARHL 245
Cdd:COG1506   226 LDFLDRHL 233
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 12-209 1.08e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 56.84  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  12 GFFPYVAERLARAGLGVVSFNFSGAGvgedsatFDEPERFGHNTYTKELRDLDIVLDALTKGaFGFQPSAygLFGHSAGG 91
Cdd:pfam12146  18 GRYAHLADALAAQGFAVYAYDHRGHG-------RSDGKRGHVPSFDDYVDDLDTFVDKIREE-HPGLPLF--LLGHSMGG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  92 GVAvLRAAQD--ERVRALV--------TWAAVARFGRLIAPLIDELRRTGTARVVSPRTG-----EELPLYRD------- 149
Cdd:pfam12146  88 LIA-ALYALRypDKVDGLIlsapalkiKPYLAPPILKLLAKLLGKLFPRLRVPNNLLPDSlsrdpEVVAAYAAdplvhgg 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 150 ISDDLdAHGAAGGGLDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGAGERQLFL 209
Cdd:pfam12146 167 ISART-LYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKL 225
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
1-245 1.94e-21

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 89.31  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGFKDWGFFPYvAERLARAGLGVVSFNFSGAGvgedsatfdepeRFGHNTYTKELRDLDIVLDALtKGAFGFQPS 80
Cdd:COG1506    28 YVHGGPGSRDDSFLPL-AQALASRGYAVLAPDYRGYG------------ESAGDWGGDEVDDVLAAIDYL-AARPYVDPD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  81 AYGLFGHSAGGGVAVLRAAQD-ERVRALVTWAAVARFGRLiaplidelrrtgtARVVSPRTGEELPLYRDISDDLDAHga 159
Cdd:COG1506    94 RIGIYGHSYGGYMALLAAARHpDRFKAAVALAGVSDLRSY-------------YGTTREYTERLMGGPWEDPEAYAAR-- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 160 aggglDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGA--GERQLFLVDGAGHGFgaghpwtgSNPALEQVVRRT 237
Cdd:COG1506   159 -----SPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagKPVELLVYPGEGHGF--------SGAGAPDYLERI 225


                  ....*...
gi 1125431682 238 LDWFARHL 245
Cdd:COG1506   226 LDFLDRHL 233
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 1-211 9.70e-20

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 84.97  E-value: 9.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGFKDWgFFPYvAERLARAGLGVVSFNFSGAGvgeDSATfdEPERFGhntyTKELRDLDIVLDALTKGAFGfQPS 80
Cdd:COG1073    42 VAHGNGGVKEQ-RALY-AQRLAELGFNVLAFDYRGYG---ESEG--EPREEG----SPERRDARAAVDYLRTLPGV-DPE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  81 AYGLFGHSAGGGVAVLRAAQDERVRALVTWAAVARFGRLIApliDELRRTGTARVVSPRTGEELPLYRDISDDLDAhgaa 160
Cdd:COG1073   110 RIGLLGISLGGGYALNAAATDPRVKAVILDSPFTSLEDLAA---QRAKEARGAYLPGVPYLPNVRLASLLNDEFDP---- 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1125431682 161 gggldvMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAgAGERQLFLVD 211
Cdd:COG1073   183 ------LAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAA-AEPKELLIVP 226
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-246 2.52e-11

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 61.50  E-value: 2.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGfkDWGFFPYVAERLARAGLGVVSFNFSGAGvgedsatfDEPERFGHNTYTKELRDLDIVLDALTKGafgfqps 80
Cdd:COG1647    20 LLHGFTG--SPAEMRPLAEALAKAGYTVYAPRLPGHG--------TSPEDLLKTTWEDWLEDVEEAYEILKAG------- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  81 aYG---LFGHSAGGGVAVLRAAQDERVRALVTWAAVARFGRLIAPLIDELRRtgtarvVSPRTGEELPLYRDISDDLDAH 157
Cdd:COG1647    83 -YDkviVIGLSMGGLLALLLAARYPDVAGLVLLSPALKIDDPSAPLLPLLKY------LARSLRGIGSDIEDPEVAEYAY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 158 G----AAGGGL-----DVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGAGERQLFLVDgaghgfgaghpwtGSN- 227
Cdd:COG1647   156 DrtplRALAELqrlirEVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLE-------------DSGh 222

                         250       260
                  ....*....|....*....|....
gi 1125431682 228 -----PALEQVVRRTLDWFARHLS 246
Cdd:COG1647   223 vitldKDREEVAEEILDFLERLAA 246
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 12-209 1.08e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 56.84  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  12 GFFPYVAERLARAGLGVVSFNFSGAGvgedsatFDEPERFGHNTYTKELRDLDIVLDALTKGaFGFQPSAygLFGHSAGG 91
Cdd:pfam12146  18 GRYAHLADALAAQGFAVYAYDHRGHG-------RSDGKRGHVPSFDDYVDDLDTFVDKIREE-HPGLPLF--LLGHSMGG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  92 GVAvLRAAQD--ERVRALV--------TWAAVARFGRLIAPLIDELRRTGTARVVSPRTG-----EELPLYRD------- 149
Cdd:pfam12146  88 LIA-ALYALRypDKVDGLIlsapalkiKPYLAPPILKLLAKLLGKLFPRLRVPNNLLPDSlsrdpEVVAAYAAdplvhgg 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 150 ISDDLdAHGAAGGGLDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGAGERQLFL 209
Cdd:pfam12146 167 ISART-LYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKL 225
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-202 3.28e-09

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 55.39  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGFKdwGFFPYVAERLARAGLGVVSFNFSGAGvgedsatfDEPERFGH-NTYTKELRDLDIVLDALtkGAFGFQP 79
Cdd:COG2267    33 LVHGLGEHS--GRYAELAEALAAAGYAVLAFDLRGHG--------RSDGPRGHvDSFDDYVDDLRAALDAL--RARPGLP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  80 saYGLFGHSAGGGVAvLRAAQD--ERVRALVtwaavarfgrLIAPLIDElrrtgtarvvSPRTGEELPLYRDisddldah 157
Cdd:COG2267   101 --VVLLGHSMGGLIA-LLYAARypDRVAGLV----------LLAPAYRA----------DPLLGPSARWLRA-------- 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1125431682 158 gaagggLDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGA 202
Cdd:COG2267   150 ------LRLAEALARIDVPVLVLHGGADRVVPPEAARRLAARLSP 188
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-244 1.06e-08

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 53.85  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGfkDWGFFPYVAERLArAGLGVVSFNFSGAGvgeDSATFDEPerfghNTYTKELRDLDIVLDALtkgafGFQPs 80
Cdd:COG0596    28 LLHGLPG--SSYEWRPLIPALA-AGYRVIAPDLRGHG---RSDKPAGG-----YTLDDLADDLAALLDAL-----GLER- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  81 aYGLFGHSAGGGVAvLRAAQD--ERVRALVtwaavarfgrLIAPLIDELRRTGTARVVSPRTgeelplyrdisddLDAHG 158
Cdd:COG0596    91 -VVLVGHSMGGMVA-LELAARhpERVAGLV----------LVDEVLAALAEPLRRPGLAPEA-------------LAALL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 159 AAGGGLDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDLHTAAGAGERQLFlvdgaghgfgaghPWTGSNPALEQ---VVR 235
Cdd:COG0596   146 RALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVL-------------PGAGHFPPLEQpeaFAA 212


                  ....*....
gi 1125431682 236 RTLDWFARH 244
Cdd:COG0596   213 ALRDFLARL 221
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
1-242 2.59e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 49.96  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGFKDWgfFPYVAERLARAGLGVVSFN-FSGAGVGEDSATFDEpeRFGHNTYTKELRDLDIVLDALtKGAFGFQP 79
Cdd:COG0412    34 VLHEIFGLNPH--IRDVARRLAAAGYVVLAPDlYGRGGPGDDPDEARA--LMGALDPELLAADLRAALDWL-KAQPEVDA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  80 SAYGLFGHSAGGGVAVLRAAQDERVRalvtwAAVARFGRLIAPLIDELrrtgtarvvsprtgeelplyrdisddldahga 159
Cdd:COG0412   109 GRVGVVGFCFGGGLALLAAARGPDLA-----AAVSFYGGLPADDLLDL-------------------------------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 160 agggldvmraAGAVRAPWLIVHGTADQTVPWGDGRDLHTA--AGAGERQLFLVDGAGHGFGAGHPWTGSNPALEQVVRRT 237
Cdd:COG0412   152 ----------AARIKAPVLLLYGEKDPLVPPEQVAALEAAlaAAGVDVELHVYPGAGHGFTNPGRPRYDPAAAEDAWQRT 221


                  ....*
gi 1125431682 238 LDWFA 242
Cdd:COG0412   222 LAFLA 226
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 1-196 1.40e-05

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 44.80  E-value: 1.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFqgFKDWGFFPYVAERLARAGLGVVSFNFSGAGvgedsatFDEPERFGHNTYTKEL-RDLDIVLDALTKGAFGfqp 79
Cdd:pfam00561   5 LLHGL--PGSSDLWRKLAPALARDGFRVIALDLRGFG-------KSSRPKAQDDYRTDDLaEDLEYILEALGLEKVN--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  80 saygLFGHSAGGGVAVLRAAQ-DERVRALVT---------WAAVARFGRLI-----------------APLIDELRRT-- 130
Cdd:pfam00561  73 ----LVGHSMGGLIALAYAAKyPDRVKALVLlgaldppheLDEADRFILALfpgffdgfvadfapnplGRLVAKLLALll 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1125431682 131 GTARVVSPRTGEELPLYRDISDD--LDAHGAAGG-----GLDVMRAAGAVRAPWLIVHGTADQTVPWGDGRDL 196
Cdd:pfam00561 149 LRLRLLKALPLLNKRFPSGDYALakSLVTGALLFietwsTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKL 221
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
1-245 2.84e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 44.33  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682   1 MCHGFQGfkDWGFFPYVAERLARAGLGVVSFNFSGAGVGEDSATFD-EPERFGHNTYTKELRDLDIVLDALTK-----GA 74
Cdd:COG4188    67 LSHGLGG--SREGYAYLAEHLASHGYVVAAPDHPGSNAADLSAALDgLADALDPEELWERPLDLSFVLDQLLAlnksdPP 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  75 FGFQ--PSAYGLFGHSAGGGVAVLraaqdervralvtwAAVARFgrliaPLIDELRRTGTARVVSPRTGEELPLYRDISD 152
Cdd:COG4188   145 LAGRldLDRIGVIGHSLGGYTALA--------------LAGARL-----DFAALRQYCGKNPDLQCRALDLPRLAYDLRD 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682 153 D-------LDAHGAAGGGLDVMRaagAVRAPWLIVHGTADQTVP-WGDGRDLHTAAGAGERQLFLVD------------- 211
Cdd:COG4188   206 PrikavvaLAPGGSGLFGEEGLA---AITIPVLLVAGSADDVTPaPDEQIRPFDLLPGADKYLLTLEgathfsfldpctp 282

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1125431682 212 GAGHGFGAGHPWTGSNPALEQVVRRTLDWFARHL 245
Cdd:COG4188   283 GAAILPEPDPPGPDRAAIHEYLNALSLAFFDAYL 316
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
17-189 7.09e-04

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 39.38  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  17 VAERLARAGLGVVSFNFsgAGVGEDSATFDEperfGHNtytkELRDLDIVLDALTKGafgfQPSAYGLFGHSAGGGVAVL 96
Cdd:COG2945    47 LARALVAAGFAVLRFNF--RGVGRSEGEFDE----GRG----ELDDAAAALDWLRAQ----NPLPLWLAGFSFGAYVALQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431682  97 RAAQDERVRALVtwaavarfgrLIAPlidELRRTGTARVVSPRtgeelplyrdisddldahgaagggldvmraagavrAP 176
Cdd:COG2945   113 LAMRLPEVEGLI----------LVAP---PVNRYDFSFLAPCP-----------------------------------AP 144

                         170
                  ....*....|...
gi 1125431682 177 WLIVHGTADQTVP 189
Cdd:COG2945   145 TLVIHGEQDEVVP 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH