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Conserved domains on  [gi|1125442092|gb|OLD69398|]
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MAG: hypothetical protein AUF63_00680 [Candidatus Rokubacteria bacterium 13_1_20CM_70_15]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 39-163 6.91e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.83  E-value: 6.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  39 AEVRTLVEASVPAAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLsNVAFRHADLARGNt 118
Cdd:COG2226     5 AARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1125442092 119 FREGAFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAVFVNHTR 163
Cdd:COG2226    83 FPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 39-163 6.91e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.83  E-value: 6.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  39 AEVRTLVEASVPAAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLsNVAFRHADLARGNt 118
Cdd:COG2226     5 AARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1125442092 119 FREGAFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAVFVNHTR 163
Cdd:COG2226    83 FPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 60-154 4.74e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 86.85  E-value: 4.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  60 VLDIACGPGNFTCLLAE-CGFTVTGLDAYGALVEVAKEKRRAKHLsNVAFRHADlARGNTFREGAFDQVVNIHSLYVHPA 138
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGD-AEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*...
gi 1125442092 139 PD--ALLREAFRVLKPGG 154
Cdd:pfam13649  79 PDleAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 59-159 6.42e-18

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 76.70  E-value: 6.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAE-CGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGNTFREGAFDQVVNIHSL-YVH 136
Cdd:cd02440     1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLhHLV 80

                          90       100
                  ....*....|....*....|...
gi 1125442092 137 PAPDALLREAFRVLKPGGHAVFV 159
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLT 103
PRK08317 PRK08317
hypothetical protein; Provisional
 59-157 3.42e-16

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 74.97  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLA-ECGFT--VTGLDAYGALVEVAKEkRRAKHLSNVAFRHADlARGNTFREGAFDQVVNIHSLYV 135
Cdd:PRK08317   22 RVLDVGCGPGNDARELArRVGPEgrVVGIDRSEAMLALAKE-RAAGLGPNVEFVRGD-ADGLPFPDGSFDAVRSDRVLQH 99

                          90       100
                  ....*....|....*....|..
gi 1125442092 136 HPAPDALLREAFRVLKPGGHAV 157
Cdd:PRK08317  100 LEDPARALAEIARVLRPGGRVV 121
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 46-157 1.71e-09

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 56.12  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  46 EASVPAAVDRREVRVLDIACGPGNFTCLLAECGFT---VTGLDAYGALVEVAKEKRRAKhlSNVAFRHADlARGNTFREG 122
Cdd:TIGR01934  29 RRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVAKKKSELP--LNIEFIQAD-AEALPFEDN 105

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1125442092 123 AFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAV 157
Cdd:TIGR01934 106 SFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLV 140
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 39-163 6.91e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 95.83  E-value: 6.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  39 AEVRTLVEASVPAAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLsNVAFRHADLARGNt 118
Cdd:COG2226     5 AARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1125442092 119 FREGAFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAVFVNHTR 163
Cdd:COG2226    83 FPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSP 127
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 60-154 4.74e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 86.85  E-value: 4.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  60 VLDIACGPGNFTCLLAE-CGFTVTGLDAYGALVEVAKEKRRAKHLsNVAFRHADlARGNTFREGAFDQVVNIHSLYVHPA 138
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGD-AEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*...
gi 1125442092 139 PD--ALLREAFRVLKPGG 154
Cdd:pfam13649  79 PDleAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 59-158 5.03e-22

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 87.77  E-value: 5.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEkrRAKHLsNVAFRHADLARGnTFREGAFDQVVNIHSLYVHPA 138
Cdd:COG2227    27 RVLDVGCGTGRLALALARRGADVTGVDISPEALEIARE--RAAEL-NVDFVQGDLEDL-PLEDGSFDLVICSEVLEHLPD 102

                          90       100
                  ....*....|....*....|
gi 1125442092 139 PDALLREAFRVLKPGGHAVF 158
Cdd:COG2227   103 PAALLRELARLLKPGGLLLL 122
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 61-158 9.34e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 80.79  E-value: 9.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  61 LDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLArgntFREGAFDQVVNIHSLYVHPAPD 140
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVVGDAEDLP----FPDNSFDLVLSSEVLHHVEDPE 76

                          90
                  ....*....|....*...
gi 1125442092 141 ALLREAFRVLKPGGHAVF 158
Cdd:pfam08241  77 RALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 59-159 6.42e-18

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 76.70  E-value: 6.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAE-CGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGNTFREGAFDQVVNIHSL-YVH 136
Cdd:cd02440     1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLhHLV 80

                          90       100
                  ....*....|....*....|...
gi 1125442092 137 PAPDALLREAFRVLKPGGHAVFV 159
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLT 103
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 55-159 8.48e-18

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 78.80  E-value: 8.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  55 RREVRVLDIACGPGNFTCLLAE-CGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGNTFREGAFDQVVNIHSL 133
Cdd:COG0500    25 PKGGRVLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLPAESFDLVVAFGVL 104

                          90       100
                  ....*....|....*....|....*...
gi 1125442092 134 YVHPA--PDALLREAFRVLKPGGHAVFV 159
Cdd:COG0500   105 HHLPPeeREALLRELARALKPGGVLLLS 132
PRK08317 PRK08317
hypothetical protein; Provisional
 59-157 3.42e-16

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 74.97  E-value: 3.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLA-ECGFT--VTGLDAYGALVEVAKEkRRAKHLSNVAFRHADlARGNTFREGAFDQVVNIHSLYV 135
Cdd:PRK08317   22 RVLDVGCGPGNDARELArRVGPEgrVVGIDRSEAMLALAKE-RAAGLGPNVEFVRGD-ADGLPFPDGSFDAVRSDRVLQH 99

                          90       100
                  ....*....|....*....|..
gi 1125442092 136 HPAPDALLREAFRVLKPGGHAV 157
Cdd:PRK08317  100 LEDPARALAEIARVLRPGGRVV 121
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
59-159 1.39e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 70.24  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAEC--GFTVTGLDAYGALVEVAKEkrrakHLSNVAFRHADLArgnTFR-EGAFDQVVNIHSLYV 135
Cdd:COG4106     4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARA-----RLPNVRFVVADLR---DLDpPEPFDLVVSNAALHW 75

                          90       100
                  ....*....|....*....|....
gi 1125442092 136 HPAPDALLREAFRVLKPGGHAVFV 159
Cdd:COG4106    76 LPDHAALLARLAAALAPGGVLAVQ 99
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 59-163 1.49e-15

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 71.50  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAE-CGFTVTGLDAYGALVEVAKEKRRAKHLSN-VAFRHADLArgNTFREGAFDQVVNIHSL-YV 135
Cdd:COG2230    54 RVLDIGCGWGGLALYLARrYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYR--DLPADGQFDAIVSIGMFeHV 131

                          90       100
                  ....*....|....*....|....*....
gi 1125442092 136 HPAP-DALLREAFRVLKPGGhaVFVNHTR 163
Cdd:COG2230   132 GPENyPAYFAKVARLLKPGG--RLLLHTP 158
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
23-162 1.58e-15

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 71.95  E-value: 1.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  23 VYDYIFERFAPYQQLQAEVRTLVEAsvpaAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRrakh 102
Cdd:COG4976    17 SYDAALVEDLGYEAPALLAEELLAR----LPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG---- 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092 103 lSNVAFRHADLARGnTFREGAFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAVFVNHT 162
Cdd:COG4976    89 -VYDRLLVADLADL-AEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVED 146
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 51-226 2.74e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 70.92  E-value: 2.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  51 AAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRakhlsnvafRHADLARGNTFREGAFDQVVNI 130
Cdd:pfam13489  17 LPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVR---------FDQFDEQEAAVPAGKFDVIVAR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092 131 HSLYVHPAPDALLREAFRVLKPGGHAVFVNHTRQVGQWSTLGEIWkreglavalrglLWVLPNsifeaarmpIGPHYWNE 210
Cdd:pfam13489  88 EVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWP------------YLRPRN---------GHISLFSA 146

                         170
                  ....*....|....*.
gi 1125442092 211 EAFAAHLRTAGFTVLE 226
Cdd:pfam13489 147 RSLKRLLEEAGFEVVS 162
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-155 3.28e-15

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 70.52  E-value: 3.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  58 VRVLDIACGPGNFTCLLAECGF---TVTGLDAYGALVEVAKEKRRAKHLSNVAFRHAD-LARGNTFREGAFDQVVNIHSL 133
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEELGpnaEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDiEELPELLEDDKFDVVISNCVL 84

                          90       100
                  ....*....|....*....|..
gi 1125442092 134 YVHPAPDALLREAFRVLKPGGH 155
Cdd:pfam13847  85 NHIPDPDKVLQEILRVLKPGGR 106
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 59-157 2.07e-12

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 64.79  E-value: 2.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAE---CGFTVTGLDAYGALVEVAKEKRRAKHLS-NVAFRHAD---LargnTFREGAFDQVV--- 128
Cdd:PRK00216   54 KVLDLACGTGDLAIALAKavgKTGEVVGLDFSEGMLAVGREKLRDLGLSgNVEFVQGDaeaL----PFPDNSFDAVTiaf 129

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1125442092 129 ---NIhslyvhPAPDALLREAFRVLKPGGHAV 157
Cdd:PRK00216  130 glrNV------PDIDKALREMYRVLKPGGRLV 155
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 61-155 4.36e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 55.07  E-value: 4.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  61 LDIACGPGNFTCLLAE--CGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGNTFREGAFDQVVNIHSLYVHPA 138
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*..
gi 1125442092 139 PDALLREAFRVLKPGGH 155
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGV 97
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
54-154 6.35e-10

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 57.45  E-value: 6.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  54 DRREVRVLDIACGPGNFTCLLAEC---GFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADlARGNTFREGAFDQVVNI 130
Cdd:pfam01209  40 VKRGNKFLDVAGGTGDWTFGLSDSagsSGKVVGLDINENMLKEGEKKAKEEGKYNIEFLQGN-AEELPFEDDSFDIVTIS 118

                          90       100
                  ....*....|....*....|....
gi 1125442092 131 HSLYVHPAPDALLREAFRVLKPGG 154
Cdd:pfam01209 119 FGLRNFPDYLKVLKEAFRVLKPGG 142
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 46-157 1.71e-09

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 56.12  E-value: 1.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  46 EASVPAAVDRREVRVLDIACGPGNFTCLLAECGFT---VTGLDAYGALVEVAKEKRRAKhlSNVAFRHADlARGNTFREG 122
Cdd:TIGR01934  29 RRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVAKKKSELP--LNIEFIQAD-AEALPFEDN 105

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1125442092 123 AFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAV 157
Cdd:TIGR01934 106 SFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLV 140
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
59-113 5.57e-09

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 55.93  E-value: 5.57e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1125442092  59 RVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADL 113
Cdd:PRK13168  300 RVLDLFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLDNVTFYHANL 354
arsM PRK11873
arsenite methyltransferase;
59-155 1.54e-08

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 53.80  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGnFTCLLA--ECGFT--VTGLDAYGALVEVAKEKRRAKHLSNVAFRHAD-----LArgntfrEGAFDqvVN 129
Cdd:PRK11873   80 TVLDLGSGGG-FDCFLAarRVGPTgkVIGVDMTPEMLAKARANARKAGYTNVEFRLGEiealpVA------DNSVD--VI 150

                          90       100
                  ....*....|....*....|....*...
gi 1125442092 130 IHSLYVHPAPD--ALLREAFRVLKPGGH 155
Cdd:PRK11873  151 ISNCVINLSPDkeRVFKEAFRVLKPGGR 178
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 59-186 2.04e-08

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 52.78  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGntFREGA-FDQVVnihslyVHP 137
Cdd:COG2518    69 RVLEIGTGSGYQAAVLARLAGRVYSVERDPELAERARERLAALGYDNVTVRVGDGALG--WPEHApFDRII------VTA 140

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1125442092 138 A----PDALLREafrvLKPGGHAVFVNHTRQVgQWSTL----GEIWKREGL----AVALRG 186
Cdd:COG2518   141 AapevPEALLEQ----LAPGGRLVAPVGEGGV-QRLVLitrtGDGFERESLfevrFVPLRG 196
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 28-158 2.64e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.06  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  28 FERFAPYQQlQAEVRTLveASVPAAVDRREVRVLDIACGPGNFTCLLAECG--FTVTGLDAYGALVEVAKEKRRAkhlsN 105
Cdd:TIGR02072   9 YDRHAKIQR-EMAKRLL--ALLKEKGIFIPASVLDIGCGTGYLTRALLKRFpqAEFIALDISAGMLAQAKTKLSE----N 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1125442092 106 VAFRHADLARgNTFREGAFDQVVNihSLYVHPA--PDALLREAFRVLKPGGHAVF 158
Cdd:TIGR02072  82 VQFICGDAEK-LPLEDSSFDLIVS--NLALQWCddLSQALSELARVLKPGGLLAF 133
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 39-150 3.50e-08

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 52.53  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  39 AEVRTLVEASVPAAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLS-NVAFRHADLARGN 117
Cdd:PRK07580   46 QRMRDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAgNITFEVGDLESLL 125

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1125442092 118 tfreGAFDQVVNIHSLYVHPAPDALlrEAFRVL 150
Cdd:PRK07580  126 ----GRFDTVVCLDVLIHYPQEDAA--RMLAHL 152
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 38-128 1.01e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 49.02  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  38 QAEVrtLVEASVPAAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLAR-- 115
Cdd:COG2265   217 QAEA--LYAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEvl 294

                          90
                  ....*....|...
gi 1125442092 116 GNTFREGAFDQVV 128
Cdd:COG2265   295 PELLWGGRPDVVV 307
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 42-172 1.96e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.48  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  42 RTLVEAsvpaAVDRREVRVLDIACGPGnftCLLAEC---GFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADlARGNT 118
Cdd:COG1041    16 RALVNL----AGAKEGDTVLDPFCGTG---TILIEAgllGRRVIGSDIDPKMVEGARENLEHYGYEDADVIRGD-ARDLP 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1125442092 119 FREGAFDQVV------NIHSLYVHPaPDAL----LREAFRVLKPGGHAVFVNHTRQVGQWSTLG 172
Cdd:COG1041    88 LADESVDAIVtdppygRSSKISGEE-LLELyekaLEEAARVLKPGGRVVIVTPRDIDELLEEAG 150
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 42-159 4.34e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 45.95  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  42 RTLVEAsVPAAVDRRevrVLDIACGPGNFTCLLAEC--GFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGntF 119
Cdd:COG2813    39 RLLLEH-LPEPLGGR---VLDLGCGYGVIGLALAKRnpEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSG--V 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1125442092 120 REGAFDQVV-N--IH-SLYVHPAP-DALLREAFRVLKPGGHAVFV 159
Cdd:COG2813   113 PDGSFDLILsNppFHaGRAVDKEVaHALIADAARHLRPGGELWLV 157
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 46-159 5.20e-06

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 46.81  E-value: 5.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  46 EASVPAAVDRREVRVLDIACGPGnFTCLlaecGFT-------VTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLArgnt 118
Cdd:PLN02490  103 DALEPADLSDRNLKVVDVGGGTG-FTTL----GIVkhvdaknVTILDQSPHQLAKAKQKEPLKECKIIEGDAEDLP---- 173

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1125442092 119 FREGAFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAVFV 159
Cdd:PLN02490  174 FPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGKACLI 214
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 34-159 1.04e-05

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 45.67  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  34 YQQLQAEVRTLVEASVPAAvdrrEVRVLDIACGPGNFTCLLAECGFTVTGLDAYGalVEVAKE--KRRAKHLSNVAFRHA 111
Cdd:PRK11088   67 YQPLRDAVANLLAERLDEK----ATALLDIGCGEGYYTHALADALPEITTMQLFG--LDISKVaiKYAAKRYPQVTFCVA 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1125442092 112 DLARgNTFREGAFDQVVNIHSlyvhPAPDALLReafRVLKPGGHAVFV 159
Cdd:PRK11088  141 SSHR-LPFADQSLDAIIRIYA----PCKAEELA---RVVKPGGIVITV 180
PLN02244 PLN02244
tocopherol O-methyltransferase
 38-159 1.44e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 45.51  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  38 QAEVRTLVE----ASVPAAVDRREVRVLDIACGPGNFTCLLA-ECGFTVTG--LDAYGAlvEVAKEKRRAKHLSN-VAFR 109
Cdd:PLN02244   96 QAQIRMIEEslawAGVPDDDEKRPKRIVDVGCGIGGSSRYLArKYGANVKGitLSPVQA--ARANALAAAQGLSDkVSFQ 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1125442092 110 HADlARGNTFREGAFDQVVNIHSLYVHPAPDALLREAFRVLKPGGHAVFV 159
Cdd:PLN02244  174 VAD-ALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIV 222
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 43-158 2.98e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 44.00  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  43 TLVEASVPAAVDRREVRVLDIACGPGnftC----LLAEC-GFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGn 117
Cdd:PRK09328   95 ELVEWALEALLLKEPLRVLDLGTGSG---AialaLAKERpDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFEP- 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1125442092 118 tFREGAFDQVV-N--------IHSLyvhpAPD---------------------ALLREAFRVLKPGGHAVF 158
Cdd:PRK09328  171 -LPGGRFDLIVsNppyipeadIHLL----QPEvrdhephlalfggedgldfyrRIIEQAPRYLKPGGWLLL 236
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 34-115 3.19e-05

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 43.78  E-value: 3.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  34 YQQLQAEvRTLVEASVPAAVDRREVR-VLDIACGPGNFTCLLAE--CGFTVTGLDAYGALVEVAKEkrrakHLSNVAFRH 110
Cdd:PRK01683    9 YLKFEDE-RTRPARDLLARVPLENPRyVVDLGCGPGNSTELLVErwPAARITGIDSSPAMLAEARS-----RLPDCQFVE 82


                  ....*
gi 1125442092 111 ADLAR 115
Cdd:PRK01683   83 ADIAS 87
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
59-154 6.91e-05

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 42.50  E-value: 6.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLARGNTfREGAFDQVVnihslyVHPA 138
Cdd:PRK00312   81 RVLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRRLKQLGLHNVSVRHGDGWKGWP-AYAPFDRIL------VTAA 153

                          90
                  ....*....|....*.
gi 1125442092 139 PDALLREAFRVLKPGG 154
Cdd:PRK00312  154 APEIPRALLEQLKEGG 169
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
57-196 1.07e-04

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 42.63  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  57 EVRVLDIACGPGNFTCLLAECGFTVTglDAYGalVEV-AKEKRRAKHLSN-----VAFRHADLARgnTFREGAFDQVV-- 128
Cdd:COG0827   116 GLRILDPAVGTGNLLTTVLNQLKKKV--NAYG--VEVdDLLIRLAAVLANlqghpVELFHQDALQ--PLLIDPVDVVIsd 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092 129 ------------------------NIHSLyvhpapdaLLREAFRVLKPGGHAVFV--NHTRQVGQWSTLgeiwkREGLA- 181
Cdd:COG0827   190 lpvgyypnderakrfklkadeghsYAHHL--------FIEQSLNYLKPGGYLFFLvpSNLFESDQAAQL-----REFLKe 256

                         170
                  ....*....|....*.
gi 1125442092 182 -VALRGLLwVLPNSIF 196
Cdd:COG0827   257 kAHIQGLI-QLPESLF 271
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 59-165 2.73e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 40.91  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLA----ECGfTVTGLDAYGALVEVAKEK-RRAKHLSNVAFRHADLARGntFREGAFDQVVnihsL 133
Cdd:COG2519    94 RVLEAGTGSGALTLALAravgPEG-KVYSYERREDFAEIARKNlERFGLPDNVELKLGDIREG--IDEGDVDAVF----L 166

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1125442092 134 YVhPAPDALLREAFRVLKPGGHAV-FVNHTRQV 165
Cdd:COG2519   167 DM-PDPWEALEAVAKALKPGGVLVaYVPTVNQV 198
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
51-161 5.25e-04

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 40.33  E-value: 5.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  51 AAVDRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLS-NVAFRHADLARGNTFREGAFDQVVn 129
Cdd:PRK11036   39 AELPPRPLRVLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVSdNMQFIHCAAQDIAQHLETPVDLIL- 117

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1125442092 130 IHSLYVHPA-PDALLREAFRVLKPGGHA--VFVNH 161
Cdd:PRK11036  118 FHAVLEWVAdPKSVLQTLWSVLRPGGALslMFYNA 152
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 28-158 5.54e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 40.13  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  28 FERFAPYQQLQAEvrtLVEASVPAavdRREVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHlsnva 107
Cdd:PRK10258   20 YEQHAELQRQSAD---ALLAMLPQ---RKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADH----- 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1125442092 108 FRHADLaRGNTFREGAFDQVVNihSLYVHPAPD--ALLREAFRVLKPGGHAVF 158
Cdd:PRK10258   89 YLAGDI-ESLPLATATFDLAWS--NLAVQWCGNlsTALRELYRVVRPGGVVAF 138
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
93-184 5.67e-04

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 40.29  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  93 VAKEKRRAKHLSNVAFRHADLARGNTFREGAFDQVV---NIHSLYVHPAPDALLREAFRVLKPGGHAVFVNHTRQVGQ-- 167
Cdd:COG4798   117 SAKLAADPALYGNVRVTAFAPPDDPIAPPGSADLVLtfrNYHNWYRAGDAAAMFAAFFKALKPGGVLGVVDHRAPPGTgl 196

                          90
                  ....*....|....*....
gi 1125442092 168 --WSTLGEIwkREGLAVAL 184
Cdd:COG4798   197 eaVATLGYI--DEAYVIAL 213
rumA TIGR00479
23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA ...
 57-113 7.30e-04

23S rRNA (uracil-5-)-methyltransferase RumA; This protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129571 [Multi-domain]  Cd Length: 431  Bit Score: 40.19  E-value: 7.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1125442092  57 EVRVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADL 113
Cdd:TIGR00479 293 EERVLDAYCGMGTFTLPLAKQAKSVVGVEGVPESVEKAQQNAELNGIANVTFYHGTL 349
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 59-154 9.44e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.73  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAECG--FTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLArgNTFREGAFDQVVN---IHS- 132
Cdd:pfam05175  34 KVLDLGCGAGVLGAALAKESpdAELTMVDINARALESARENLAANGLENGEVVASDVY--SGVEDGKFDLIISnppFHAg 111

                          90       100
                  ....*....|....*....|...
gi 1125442092 133 LYVHP-APDALLREAFRVLKPGG 154
Cdd:pfam05175 112 LATTYnVAQRFIADAKRHLRPGG 134
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 54-114 1.02e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 39.29  E-value: 1.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1125442092  54 DRREVRVLDIACGPGNFTCLLAE--CGFTVTGLDAYGALVEVAKEKRrakhlsnVAFRHADLA 114
Cdd:PRK14103   27 AERARRVVDLGCGPGNLTRYLARrwPGAVIEALDSSPEMVAAARERG-------VDARTGDVR 82
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
59-159 1.47e-03

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 38.56  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  59 RVLDIACGPGNFTCLLAECGFTVTGLDAYGALVEVAKEKRRAKHLSNVAFRHADLargNTFR-EGAFDQVVNIHSL-YVH 136
Cdd:PRK11207   33 KTLDLGCGNGRNSLYLAANGFDVTAWDKNPMSIANLERIKAAENLDNLHTAVVDL---NNLTfDGEYDFILSTVVLmFLE 109

                          90       100
                  ....*....|....*....|....
gi 1125442092 137 PAP-DALLREAFRVLKPGGHAVFV 159
Cdd:PRK11207  110 AKTiPGLIANMQRCTKPGGYNLIV 133
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 43-158 4.17e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.82  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125442092  43 TLVEASVPAAVDRREVRVLDIACGPGnftC----LLAEC-GFTVTGLDAYGALVEVAKEKRRAKHLSN-VAFRHADLARG 116
Cdd:COG2890    99 ELVELALALLPAGAPPRVLDLGTGSG---AialaLAKERpDARVTAVDISPDALAVARRNAERLGLEDrVRFLQGDLFEP 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1125442092 117 NTFReGAFDQVV-N---IHSLYVHPAPD----------------------ALLREAFRVLKPGGHAVF 158
Cdd:COG2890   176 LPGD-GRFDLIVsNppyIPEDEIALLPPevrdheprlaldggedgldfyrRIIAQAPRLLKPGGWLLL 242
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
111-159 8.93e-03

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 36.00  E-value: 8.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125442092 111 ADLARGNTFREGAFDQVV---NIHSLYVHPAPDALlREAFRVLKPGGHAVFV 159
Cdd:COG4627    34 GDLTDPLPFPDNSVDAIYsshVLEHLDYEEAPLAL-KECYRVLKPGGILRIV 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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