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Conserved domains on  [gi|1167234572|gb|OQA64668|]
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Phosphocarrier protein HPr [Spirochaetes bacterium ADurb.Bin269]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10788234)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-83 2.49e-29

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


:

Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 99.79  E-value: 2.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                 ...
gi 1167234572 81 LAS 83
Cdd:COG1925   81 IES 83
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-83 2.49e-29

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 99.79  E-value: 2.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                 ...
gi 1167234572 81 LAS 83
Cdd:COG1925   81 IES 83
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
4-82 2.30e-28

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 97.07  E-value: 2.30e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1167234572  4 KNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAALA 82
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 6-81 3.19e-25

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 89.10  E-value: 3.19e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1167234572  6 ITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAAL 81
Cdd:cd00367    2 VTITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PRK10850 PRK10850
phosphocarrier protein Hpr;
1-84 2.16e-24

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 87.49  E-value: 2.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:PRK10850   1 MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKL 80


                 ....
gi 1167234572 81 LASL 84
Cdd:PRK10850  81 MAEL 84
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 1.47e-21

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 80.00  E-value: 1.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 1167234572 81 LA 82
Cdd:TIGR01003 81 FE 82
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
3-81 2.07e-10

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 51.91  E-value: 2.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  3 EKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDG---SAKNLLKLMKLGITLGNTITVRCEGEDESAALESISA 79
Cdd:NF041319   2 ERTVTVVPEAGLHARPASKFVETANEFDAEVTVGRADDDGdlvNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDALEA 81


                 ..
gi 1167234572 80 AL 81
Cdd:NF041319  82 VL 83
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-83 2.49e-29

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 99.79  E-value: 2.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:COG1925    1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                 ...
gi 1167234572 81 LAS 83
Cdd:COG1925   81 IES 83
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
4-82 2.30e-28

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 97.07  E-value: 2.30e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1167234572  4 KNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAALA 82
Cdd:pfam00381  1 KTVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS-HPr_like cd00367
Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of ...
 6-81 3.19e-25

Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate is transferred to HPr by enzyme I (EI). Phospho-HPr then transfers the phosphoryl group to one of several sugar-specific phosphoprotein intermediates. The conserved histidine in the N-terminus of HPr serves as an acceptor for the phosphoryl group of EI. In addition to the phosphotransferase proteins HPr and E1, this family also includes the closely related Carbon Catabolite Repressor (CCR) proteins which use the same phosphorylation mechanism and interact with transcriptional regulators to control expression of genes coding for utilization of less favored carbon sources.


Pssm-ID: 238217 [Multi-domain]  Cd Length: 77  Bit Score: 89.10  E-value: 3.19e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1167234572  6 ITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAAL 81
Cdd:cd00367    2 VTITNPLGLHARPAALLVQLASKFKSDITLRKGGRKANAKSILGLMSLGAKQGDEITLSAEGEDAEEALEALAELL 77
PRK10850 PRK10850
phosphocarrier protein Hpr;
1-84 2.16e-24

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 87.49  E-value: 2.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:PRK10850   1 MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKL 80


                 ....
gi 1167234572 81 LASL 84
Cdd:PRK10850  81 MAEL 84
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 1.47e-21

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 80.00  E-value: 1.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 1167234572 81 LA 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-79 2.35e-16

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 66.73  E-value: 2.35e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISA 79
Cdd:PRK13782   1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEALAA 79
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
7-83 8.04e-15

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 67.28  E-value: 8.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572   7 TIANPSGLHTRPAKRIVDVARAFASEITFIK---EGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAALAS 83
Cdd:PRK11109  291 VIRNEHGLHARPGAMLVNTIKQFNSEITVTNldgTGKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAIGEAIAA 370
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-83 1.79e-14

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 62.02  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  1 MVEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAA 80
Cdd:PRK13780   1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAIEET 80


                 ...
gi 1167234572 81 LAS 83
Cdd:PRK13780  81 MKK 83
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 7-83 2.99e-11

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 57.19  E-value: 2.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572   7 TIANPSGLHTRPAKRIVDVARAFASEIT---FIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISAALAS 83
Cdd:PRK13779  296 TIRNEHGLHARPSANLVNEVKKFTAKITvenLTRGSAPVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAIAE 375
PTS-HPr_Halo NF041319
phosphocarrier protein HPr;
3-81 2.07e-10

phosphocarrier protein HPr;


Pssm-ID: 469216 [Multi-domain]  Cd Length: 87  Bit Score: 51.91  E-value: 2.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572  3 EKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDG---SAKNLLKLMKLGITLGNTITVRCEGEDESAALESISA 79
Cdd:NF041319   2 ERTVTVVPEAGLHARPASKFVETANEFDAEVTVGRADDDGdlvNAASMLAVTGLGVRHGEDVRLVAEGDDAEAALDALEA 81


                 ..
gi 1167234572 80 AL 81
Cdd:NF041319  82 VL 83
PRK11377 PRK11377
dihydroxyacetone kinase subunit M; Provisional
 6-79 4.24e-09

dihydroxyacetone kinase subunit M; Provisional


Pssm-ID: 183108 [Multi-domain]  Cd Length: 473  Bit Score: 51.29  E-value: 4.24e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1167234572   6 ITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISA 79
Cdd:PRK11377  160 VVIKNRNGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESLNQIALLQVRYNDTLRLIAKGPEAEEALIAFRQ 233
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 2-83 3.27e-07

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 46.02  E-value: 3.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167234572   2 VEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKEGRDG---SAKNLLKLMKLGITLGNTITVRCEGEDESAALESIS 78
Cdd:PRK13779  415 VEGVFVIKNEHGLHARPSAVLVNEVKKYNASVAVQNLDRNTqlvSAKSLMKIVALGVVKGHRLRFVATGEEAQQAIDGIG 494


                  ....*
gi 1167234572  79 AALAS 83
Cdd:PRK13779  495 AAIAA 499
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
2-79 1.02e-05

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 39.81  E-value: 1.02e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1167234572  2 VEKNITIANPSGLHTRPAKRIVDVARAFASEITFIKE-GRDGSAKNLLKLMKLGITLGNTITVRCEGEDESAALESISA 79
Cdd:PRK10897   3 VKQTVEIKNKLGMHARPAMKLFELVQGFDAEVLLRNDeGTEAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIA 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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