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Conserved domains on  [gi|1176161222|gb|OQX77609|]
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two-component system response regulator [Epsilonproteobacteria bacterium 4484_65]

Protein Classification

response regulator transcription factor( domain architecture ID 11433066)

OmpR family response regulator transcription factor with a signal receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding domain that may be part of a two-component regulatory system

CATH:  3.40.50.2300
Gene Ontology:  GO:0006355|GO:0003677|GO:0000160|GO:0000156
PubMed:  11226872|10966457|31100988
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-198 1.33e-51

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 165.51  E-value: 1.33e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQvRKERVDIGKYsLDTVAKILYLEDKALDVTQKAIELLVLL 160
Cdd:COG0745    81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR-AAEVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLELL 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1176161222 161 VQADGEVVSSDEIKNRLWaAGQSASDGSLRVYITQLKK 198
Cdd:COG0745   159 MRNPGRVVSREQLLEEVW-GYDYGDDRTVDVHISRLRK 195
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-198 1.33e-51

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 165.51  E-value: 1.33e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQvRKERVDIGKYsLDTVAKILYLEDKALDVTQKAIELLVLL 160
Cdd:COG0745    81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR-AAEVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLELL 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1176161222 161 VQADGEVVSSDEIKNRLWaAGQSASDGSLRVYITQLKK 198
Cdd:COG0745   159 MRNPGRVVSREQLLEEVW-GYDYGDDRTVDVHISRLRK 195
ompR PRK09468
osmolarity response regulator; Provisional
 3-215 8.34e-34

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 120.85  E-value: 8.34e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK09468    7 KILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTAK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRK---------ERVDIGKYSLDTVAKILYLEDKALDVTQKA 153
Cdd:PRK09468   87 GEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAPElpgapsqeeEVIAFGKFKLNLGTRELFRGDEPMPLTTGE 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161222 154 IELLVLLVQADGEVVSSDEIKN----RLWaagqSASDGSLRVYITQLKKYF------PEAISNVRGIGYRWV 215
Cdd:PRK09468  167 FAVLKALVSHPREPLSRDKLMNlargREY----SAMERSIDVQISRLRRLIeedpahPRYIQTVWGLGYVFV 234
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-103 2.92e-30

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 107.49  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   5 LVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDD 84
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                          90
                  ....*....|....*....
gi 1176161222  85 KDSLTQGFSIGADDYMKKP 103
Cdd:cd17574    81 EEDKVLGLELGADDYITKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-112 1.32e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 95.68  E-value: 1.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100
                  ....*....|....*....|....*....
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLR 112
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAA 109
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 144-214 8.00e-14

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 64.11  E-value: 8.00e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176161222  144 DKALDVTQKAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYF-----PEAISNVRGIGYRW 214
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLeddgdPRLIETVRGVGYRL 76
 
Name Accession Description Interval E-value
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-198 1.33e-51

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 165.51  E-value: 1.33e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:COG0745     1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQvRKERVDIGKYsLDTVAKILYLEDKALDVTQKAIELLVLL 160
Cdd:COG0745    81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRR-AAEVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLELL 158

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1176161222 161 VQADGEVVSSDEIKNRLWaAGQSASDGSLRVYITQLKK 198
Cdd:COG0745   159 MRNPGRVVSREQLLEEVW-GYDYGDDRTVDVHISRLRK 195
ompR PRK09468
osmolarity response regulator; Provisional
 3-215 8.34e-34

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 120.85  E-value: 8.34e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK09468    7 KILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTAK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRK---------ERVDIGKYSLDTVAKILYLEDKALDVTQKA 153
Cdd:PRK09468   87 GEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVLRRQAPElpgapsqeeEVIAFGKFKLNLGTRELFRGDEPMPLTTGE 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161222 154 IELLVLLVQADGEVVSSDEIKN----RLWaagqSASDGSLRVYITQLKKYF------PEAISNVRGIGYRWV 215
Cdd:PRK09468  167 FAVLKALVSHPREPLSRDKLMNlargREY----SAMERSIDVQISRLRRLIeedpahPRYIQTVWGLGYVFV 234
PRK10643 PRK10643
two-component system response regulator PmrA;
3-217 3.29e-32

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 116.29  E-value: 3.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK10643    2 KILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRK--ERVDIGKYSLDTVAKILYLEDKALDVTQKAIELLVLL 160
Cdd:PRK10643   82 DTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQgeNELQVGNLTLNLGRQQVWLDGQELILTPKEFALLSRL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161222 161 VQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLK-KYFPEAISNVRGIGYRWVTN 217
Cdd:PRK10643  162 MLKAGSPVHREILYQDIYNWDDEPSSNTLEVHIHNLRdKVGKDRIRTVRGFGYMLVAN 219
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-212 8.78e-31

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 112.75  E-value: 8.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:PRK11083    3 QPTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKER----VDIGKYSLDTVAKILYLEDKALDVTQKAIEL 156
Cdd:PRK11083   83 ARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFAApspvIRIGHFELDEPAARISYFGTPLTLTRYEFLL 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161222 157 LVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYI----TQLKKYFPEA--ISNVRGIGY 212
Cdd:PRK11083  163 LKTLLLSPGRVFSRQQLMDIVWEDAQDSYDRTVDTHIktlrAKLRAINPDLspINTHRGMGY 224
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-118 1.39e-30

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 110.77  E-value: 1.39e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIF 78
Cdd:COG3706     1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTadIPIIF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR 118
Cdd:COG3706    81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVAR 120
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-103 2.92e-30

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 107.49  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   5 LVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDD 84
Cdd:cd17574     1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                          90
                  ....*....|....*....
gi 1176161222  85 KDSLTQGFSIGADDYMKKP 103
Cdd:cd17574    81 EEDKVLGLELGADDYITKP 99
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-118 4.64e-30

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 107.57  E-value: 4.64e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17624     1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR 118
Cdd:cd17624    81 GVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
PRK11517 PRK11517
DNA-binding response regulator HprR;
3-215 8.31e-30

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 109.99  E-value: 8.31e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLTSR 82
Cdd:PRK11517    2 KILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLR-TAKQTPVICLTAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQV-RKERVDIGKYSLDTVAKILYLEDKALDVTQKAIELLVLLV 161
Cdd:PRK11517   81 DSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHaLNSTLEISGLRMDSVSQSVSRDNISITLTRKEFQLLWLLA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161222 162 QADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKY----FPEA-ISNVRGIGYRWV 215
Cdd:PRK11517  161 SRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKvddpFPEKlIATIRGMGYSFV 219
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-119 2.94e-29

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 105.38  E-value: 2.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   5 LVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDD 84
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDA 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176161222  85 KDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd17625    81 VEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-127 6.91e-29

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 107.56  E-value: 6.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIF 78
Cdd:COG3437     6 APTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTrdIPVIF 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKERVD 127
Cdd:COG3437    86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELD 134
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-127 3.87e-28

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 109.67  E-value: 3.87e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:COG2204     2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKERVD 127
Cdd:COG2204    82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENA 128
PRK15479 PRK15479
transcriptional regulator TctD;
3-213 6.74e-28

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 105.19  E-value: 6.74e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK15479    2 RLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQ--VRKERVDIGKYSLDTVAKILyLEDKALDVTQKAIELLVLL 160
Cdd:PRK15479   82 SAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSagQVQEVQQLGELIFHDEGYFL-LQGQPLALTPREQALLTVL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1176161222 161 VQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYFPE---AISNVRGIGYR 213
Cdd:PRK15479  161 MYRRTRPVSRQQLFEQVFSLNDEVSPESIELYIHRLRKKLQGsdvRITTLRGLGYV 216
PRK10336 PRK10336
two-component system response regulator QseB;
3-212 8.63e-28

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 104.59  E-value: 8.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK10336    2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR---QVRKErVDIGKYSLDTVAKILYLEDKALDVTQKAIELLVL 159
Cdd:PRK10336   82 DALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRtngQASNE-LRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1176161222 160 LVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQL-KKYFPEAISNVRGIGY 212
Cdd:PRK10336  161 LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLrRKLGSDFIRTVHGIGY 214
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-216 8.71e-27

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 102.57  E-value: 8.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVfDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLT 80
Cdd:PRK10955    1 MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSI-DLLLLDVMMPKKNGIDTLKELR-QTHQTPVIMLT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQ---VRKERVDIGKYSLDTVAKIL-------YLEDKALDVT 150
Cdd:PRK10955   79 ARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRShwsEQQQNNDNGSPTLEVDALSLnpgrqeaSFDGQTLELT 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176161222 151 QKAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYFPEA------ISNVRGIGYRWVT 216
Cdd:PRK10955  159 GTEFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPDRkdghpwFKTLRGRGYLMVS 230
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-122 1.78e-26

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 98.77  E-value: 1.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLR--GSGDTTPAIF 78
Cdd:COG0784     5 GKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRalPRLPDIPIIA 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVR 122
Cdd:COG0784    85 LTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-103 8.77e-26

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 95.76  E-value: 8.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   5 LVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDD 84
Cdd:cd00156     1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                          90
                  ....*....|....*....
gi 1176161222  85 KDSLTQGFSIGADDYMKKP 103
Cdd:cd00156    81 EEDAVRALELGADDYLVKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-112 1.32e-25

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 95.68  E-value: 1.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100
                  ....*....|....*....|....*....
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLR 112
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAA 109
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-119 4.23e-25

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 94.73  E-value: 4.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:cd17615     1 RVLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd17615    81 DSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-119 7.41e-25

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 93.91  E-value: 7.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTSRD 83
Cdd:cd17623     1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQ-VPVLMLTARG 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd17623    80 DDIDRILGLELGADDYLPKPFNPRELVARIRAILRR 115
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 3-212 7.83e-25

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 97.30  E-value: 7.83e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK09836    2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR---QVRKERVDIGKYSLDTVAKILYLEDKALDVTQKAIELLVL 159
Cdd:PRK09836   82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRgaaVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLEF 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161222 160 LVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLK-----KYFPEAISNVRGIGY 212
Cdd:PRK09836  162 FLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRgkidnDFEPKLIQTVRGVGY 219
orf27 CHL00148
Ycf27; Reviewed
 3-212 1.13e-24

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 97.09  E-value: 1.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTtPAIFLTSR 82
Cdd:CHL00148    8 KILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDV-PIIMLTAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DD-KDSLTqGFSIGADDYMKKPIDLDELLLRMQAVLRRQVR---------KERVDIGKYSLDTVAKILYLEDKALDVTQK 152
Cdd:CHL00148   87 GDvSDRIT-GLELGADDYVVKPFSPKELEARIRSVLRRTNKksfsskipnSSIIRIGFLKIDLNKKQVYKNNERIRLTGM 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161222 153 AIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGS--LRVYITQLKKYF------PEAISNVRGIGY 212
Cdd:CHL00148  166 EFSLLELLISKSGEIFSRATILKEVWGYTPERHIDTrvVDVHISRLRAKLeddpsnPDLILTARGTGY 233
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-103 1.14e-24

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 92.89  E-value: 1.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80

                          90       100
                  ....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKP 103
Cdd:cd19935    81 SVEDRVKGLDLGADDYLVKP 100
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-119 1.30e-24

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 93.50  E-value: 1.30e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd19934     1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd19934    81 SWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRR 116
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
3-216 1.66e-24

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 96.33  E-value: 1.66e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFLT 80
Cdd:PRK10161    4 RILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdIPVVMLT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR---QVRKERVDIGKYSLDTVAKILYLEDKALDVTQKAIELL 157
Cdd:PRK10161   84 ARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRispMAVEEVIEMQGLSLDPTSHRVMAGEEPLEMGPTEFKLL 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176161222 158 VLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYFPEA-----ISNVRGIGYRWVT 216
Cdd:PRK10161  164 HFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGghdrmVQTVRGTGYRFST 227
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-119 1.14e-23

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 90.91  E-value: 1.14e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17627     1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd17627    81 SVSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-120 1.64e-22

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 88.87  E-value: 1.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEE-EGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIF 78
Cdd:COG4565     3 MIRVLIVEDDPMVAELLRRYLERlPGFEvVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQ 120
Cdd:COG4565    83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYR 124
PRK10816 PRK10816
two-component system response regulator PhoP;
3-214 7.95e-22

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 89.03  E-value: 7.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK10816    2 RVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTAR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQ--VRKERVDIGKYSLDTVAKILYLEDKALDVTQKAIELLVLL 160
Cdd:PRK10816   82 ESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNsgLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161222 161 VQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKK-----YFPEAISNVRGIGYRW 214
Cdd:PRK10816  162 IRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKkiqaqYPQEVITTVRGQGYRF 220
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-119 9.53e-21

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 83.63  E-value: 9.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTSRD 83
Cdd:cd17614     1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSN-VPIIMLTAKD 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd17614    80 SEVDKVLGLELGADDYVTKPFSNRELLARVKANLRR 115
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 2-114 1.42e-20

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 82.87  E-value: 1.42e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRG--SGDTTPAIF 78
Cdd:cd17551     1 MRILIVDDNPTNLLLLEALLRSAGYLeVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRAlpGLEDVPIVM 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQ 114
Cdd:cd17551    81 ITADTDREVRLRALEAGATDFLTKPFDPVELLARVR 116
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 2-112 1.91e-20

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 82.43  E-value: 1.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLTS 81
Cdd:cd17619     1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELR-EQSEVGIILVTG 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELLLR 112
Cdd:cd17619    80 RDDEVDRIVGLEIGADDYVTKPFNPRELLVR 110
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-117 2.72e-20

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 82.07  E-value: 2.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17616     1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17616    81 DIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 1-215 3.10e-20

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 84.86  E-value: 3.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLT 80
Cdd:PRK10529    1 MTNVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLR-QWSAIPVIVLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKER----VDIGKYSLDTVAKILYLEDKALDVTQKAIEL 156
Cdd:PRK10529   80 ARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRRHSATPApdplVKFSDVTVDLAARVIHRGEEEVHLTPIEFRL 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176161222 157 LVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYF------PEAISNVRGIGYRWV 215
Cdd:PRK10529  160 LAVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIYMGHLRQKLeqdparPRHFITETGIGYRFM 224
PRK10766 PRK10766
two-component system response regulator TorR;
3-209 7.80e-20

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 83.93  E-value: 7.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLTSR 82
Cdd:PRK10766    4 HILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELR-SRSTVGIILVTGR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR--QVRKERVDI---------GKYSLDTVAKILYLEDKALDVTQ 151
Cdd:PRK10766   83 TDSIDRIVGLEMGADDYVTKPLELRELLVRVKNLLWRisLARQAQPHAqeedncyrfAGYCLNVSRRTLERNGEPIKLTK 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161222 152 KAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLK-KYFPEAISNVRG 209
Cdd:PRK10766  163 AEYELLVAFVTNPGQVLSRERLLRMLSHRVENPNDRTIDVLIRRLRhKLNPDLFVTQHG 221
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-118 1.92e-19

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 80.01  E-value: 1.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   5 LVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFLTSR 82
Cdd:cd19937     1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTssIPIIMLTAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR 118
Cdd:cd19937    81 GEEFDKVLGLELGADDYITKPFSPRELLARVKAVLR 116
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-136 1.23e-18

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 79.58  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTsr 82
Cdd:COG4567     6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT-- 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176161222  83 ddkdsltqGF-SI---------GADDYMKKPIDLDELLlrmQAVLRRQVRKERVDIGKYSLDTV 136
Cdd:COG4567    84 --------GYaSIataveaiklGADDYLAKPADADDLL---AALERAEGDAPAPPENPMSLDRL 136
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 4-117 1.78e-18

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 77.32  E-value: 1.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLTSRD 83
Cdd:cd18159     1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIR-QISNVPIIFISSRD 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd18159    80 DNMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 2-117 2.85e-18

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 76.90  E-value: 2.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFL 79
Cdd:cd17618     1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTrdIPIIML 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17618    81 TARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-104 3.46e-18

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 76.38  E-value: 3.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTT--PAIFLT 80
Cdd:cd17538     1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRhiPVIMIT 80

                          90       100
                  ....*....|....*....|....
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPI 104
Cdd:cd17538    81 ALDDREDRIRGLEAGADDFLSKPI 104
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-143 4.95e-18

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 79.09  E-value: 4.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEE-EGYTI-ECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIF 78
Cdd:COG3279     1 MMKILIVDDEPLARERLERLLEKyPDLEVvGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161222  79 LTSRDDKdsLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKERVDIGKYSLDT-------------VAKILYLE 143
Cdd:COG3279    81 TTAYDEY--ALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDRifvksggklvkipLDDILYIE 156
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 4-104 6.45e-18

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 75.63  E-value: 6.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLED--DQLfnETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFL 79
Cdd:cd19920     1 ILIVDDvpDNL--RLLSELLRAAGYRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADPATrhIPVIFL 78

                          90       100
                  ....*....|....*....|....*
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPI 104
Cdd:cd19920    79 TALTDTEDKVKGFELGAVDYITKPF 103
PRK11173 PRK11173
two-component response regulator; Provisional
 3-215 1.03e-17

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 78.52  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTtPAIFLTSR 82
Cdd:PRK11173    5 HILIVEDELVTRNTLKSIFEAEGYDVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANV-ALMFLTGR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR-----QVRKERVDIGKYS-----LDTVAKILYL-EDKALDVTQ 151
Cdd:PRK11173   84 DNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRtmnlgTVSEERRSVESYKfngweLDINSRSLISpDGEQYKLPR 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222 152 KAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYF------PEAISNVRGIGYRWV 215
Cdd:PRK11173  164 SEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFestpdtPEIIATIHGEGYRFC 233
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
128-215 1.39e-17

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 74.94  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222 128 IGKYSLDTVAKILYLEDKALDVTQKAIELLVLLVQADGEVVSSDEIKNRLWaAGQSASDGSLRVYITQLKKYF------P 201
Cdd:COG3710     5 FGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVW-PGRVVSDNSLTQAISRLRKALgddgleP 83

                          90
                  ....*....|....
gi 1176161222 202 EAISNVRGIGYRWV 215
Cdd:COG3710    84 RLIRTVPRRGYRLV 97
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 4-103 2.16e-17

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 74.02  E-value: 2.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAIFLTSRD 83
Cdd:cd19936     1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLR-QKSTLPVIFLTSKD 79

                          90       100
                  ....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKP 103
Cdd:cd19936    80 DEIDEVFGLRMGADDYITKP 99
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 3-214 6.71e-17

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 76.26  E-value: 6.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTtPAIFLTSR 82
Cdd:PRK10710   12 RILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIRRFSDI-PIVMVTAK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVR-KERVDIGKYSLDTVAKILY---LEDKALDVTQKAIELLV 158
Cdd:PRK10710   91 IEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRRCKPqRELQQQDAESPLIIDESRFqasWRGKMLDLTPAEFRLLK 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176161222 159 LLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYFpEA-------ISNVRGIGYRW 214
Cdd:PRK10710  171 TLSHEPGKVFSREQLLNHLYDDYRVVTDRTIDSHIKNLRRKL-ESldaeqsfIRAVYGVGYRW 232
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-103 9.07e-17

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 72.50  E-value: 9.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEG--YTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:COG4753     1 KVLIVDDEPLIREGLKRILEWEAgfEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                          90       100
                  ....*....|....*....|...
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKP 103
Cdd:COG4753    81 GYSDFEYAQEAIKLGADDYLLKP 103
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-119 5.45e-16

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 70.87  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTtPAIFLTSR 82
Cdd:cd19939     1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHV-PILMLTAR 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd19939    80 TEEMDRVLGLEMGADDYLCKPFSPRELLARVRALLRR 116
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-103 6.66e-16

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 70.48  E-value: 6.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGD--TTPAIFLTS 81
Cdd:cd19927     1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADfdTIPVIFLTA 80

                          90       100
                  ....*....|....*....|..
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKP 103
Cdd:cd19927    81 KGMTSDRIKGYNAGCDGYLSKP 102
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 3-118 7.22e-16

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 70.87  E-value: 7.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTSR 82
Cdd:cd17622     2 RILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQ-GPILLLTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR 118
Cdd:cd17622    81 DSDIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-117 1.96e-15

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 69.33  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTSR 82
Cdd:cd19938     1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRFSD-VPIIMVTAR 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd19938    80 VEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-128 2.91e-15

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 73.73  E-value: 2.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK11361    6 RILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAY 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLrrQVRKERVDI 128
Cdd:PRK11361   86 AEVETAVEALRCGAFDYVIKPFDLDELNLIVQRAL--QLQSMKKEI 129
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 132-214 6.54e-15

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 67.50  E-value: 6.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222 132 SLDTVAKILYLEDKALDVTQKAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYF-----PEAISN 206
Cdd:cd00383     2 RLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRTVDVHISRLRKKLeddpePRLIKT 81


                  ....*...
gi 1176161222 207 VRGIGYRW 214
Cdd:cd00383    82 VRGVGYRL 89
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 4-110 7.02e-15

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 67.87  E-value: 7.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLR--GSGDTTPAIFLT- 80
Cdd:cd17580     1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRelPWLANTPAIALTg 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1176161222  81 ---SRDDKDSLTQGFsigaDDYMKKPIDLDELL 110
Cdd:cd17580    81 ygqPEDRERALEAGF----DAHLVKPVDPDELI 109
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 2-117 7.08e-15

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 67.88  E-value: 7.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTS 81
Cdd:cd17626     1 ARILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAESG-VPIVMLTA 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17626    80 KSDTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-110 8.27e-15

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 67.88  E-value: 8.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLR---GSGDTTPAIFLT 80
Cdd:cd17546     1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIReleGGGRRTPIIALT 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELL 110
Cdd:cd17546    81 ANALEEDREKCLEAGMDDYLSKPVKLDQLK 110
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 2-109 8.62e-15

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 67.63  E-value: 8.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTS 81
Cdd:cd17554     1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80

                          90       100
                  ....*....|....*....|....*....
gi 1176161222  82 RDD-KDSLTqgfSIGADDYMKKPIDLDEL 109
Cdd:cd17554    81 YSEyKSDFS---SWAADAYVVKSSDLTEL 106
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 4-109 9.11e-15

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 67.65  E-value: 9.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDL--TYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTS 81
Cdd:cd17584     1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMlrENKDEFDLVITDVHMPDMDGFEFLELIRLEMD-LPVIMMSA 79

                          90       100
                  ....*....|....*....|....*...
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDEL 109
Cdd:cd17584    80 DGSTSTVMKGLAHGACDYLLKPVSIEDL 107
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 3-110 1.60e-14

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 67.18  E-value: 1.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFLT 80
Cdd:cd17548     1 KILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPATrdIPVIALT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176161222  81 S----RDDKDSLTQGFsigaDDYMKKPIDLDELL 110
Cdd:cd17548    81 AyamkGDREKILEAGC----DGYISKPIDTREFL 110
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 4-117 3.88e-14

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 66.20  E-value: 3.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGD--TTPAIFLTS 81
Cdd:cd17598     1 ILIVEDSPTQAEQLKHILEEQGYKVQVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDlkDIPVILLTT 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17598    81 LSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-125 4.58e-14

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 67.67  E-value: 4.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFL 79
Cdd:COG3707     3 GLRVLVVDDEPLRRADLREGLREAGYEvVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERP-APVILL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKER 125
Cdd:COG3707    82 TAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRA 127
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 3-110 5.14e-14

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 65.54  E-value: 5.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTsr 82
Cdd:cd17563     2 SLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT-- 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161222  83 ddkdsltqGF-SI---------GADDYMKKPIDLDELL 110
Cdd:cd17563    80 --------GYaSIataveaiklGADDYLAKPADADEIL 109
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 144-214 8.00e-14

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 64.11  E-value: 8.00e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176161222  144 DKALDVTQKAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYF-----PEAISNVRGIGYRW 214
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDEDVDDNTLDVHISRLRKKLeddgdPRLIETVRGVGYRL 76
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 2-123 9.78e-14

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 64.91  E-value: 9.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTS 81
Cdd:cd17555     1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPI-DLdelllrmqAVLRRQVRK 123
Cdd:cd17555    81 AGVMSDAVEALRLGAWDYLTKPIeDL--------AVLEHAVRR 115
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 4-113 1.27e-13

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 64.76  E-value: 1.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17573     1 ILLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLSDNP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRM 113
Cdd:cd17573    81 KTEQEIEAFKEGADDYIAKPFDFKVLVARI 110
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-124 5.10e-13

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 63.37  E-value: 5.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17572     1 VLLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKE 124
Cdd:cd17572    81 SVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNALKHRKLTK 121
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-103 8.46e-13

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 62.22  E-value: 8.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFLTSRD 83
Cdd:cd17621     1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARSN-VPVIMVTAKD 79

                          90       100
                  ....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKP 103
Cdd:cd17621    80 SEIDKVVGLELGADDYVTKP 99
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 2-117 9.75e-13

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 62.32  E-value: 9.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRG--SGDTTPAIFL 79
Cdd:cd17562     1 KKILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKlpAYKFTPILML 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17562    81 TTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-111 1.01e-12

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 62.13  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17550     1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHG 80

                          90       100
                  ....*....|....*....|....*...
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLL 111
Cdd:cd17550    81 TIETAVKATKLGAYDFIEKPLSLDRLLL 108
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-118 1.59e-12

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 61.76  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLE-EEGYTI--ECAlDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLEsEPDIEVvgEAA-DGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLT 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR 118
Cdd:cd17535    80 AHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-115 1.80e-12

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 61.69  E-value: 1.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17594     2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISGDRR 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQA 115
Cdd:cd17594    82 DEIDRVVGLELGADDYLAKPFGLRELLARVRA 113
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 3-108 3.13e-12

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 61.13  E-value: 3.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:cd19919     2 TVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAH 81

                          90       100
                  ....*....|....*....|....*.
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDE 108
Cdd:cd19919    82 SDLDSAVSAYQGGAFEYLPKPFDIDE 107
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
144-213 2.34e-11

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 57.52  E-value: 2.34e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176161222 144 DKALDVTQKAIELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKK------YFPEAISNVRGIGYR 213
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGEDYDVDDNTVDVHISRLRKkleddpRDPRLIKTVRGVGYR 76
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 3-119 2.94e-11

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 58.58  E-value: 2.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIEC-ALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSgDTTPAIFLTS 81
Cdd:cd19932     2 RVLIAEDEALIRMDLREMLEEAGYEVVGeASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSE-NIAPIVLLTA 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRR 119
Cdd:cd19932    81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-110 3.42e-11

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 58.12  E-value: 3.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIE---CALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:cd17536     1 VLIVDDEPLIREGLKKLIDWEELGFEvvgEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELL 110
Cdd:cd17536    81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELE 110
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-110 4.41e-11

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 57.80  E-value: 4.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTI-ECALDPYSALDLTYKHVFDLYLFDVNLPYE-NGFDLLEKLRGSGDTtPAIFL 79
Cdd:cd17534     1 KKILIVEDEAIIALDLKEILESLGYEVvGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREKFDI-PVIFL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPIDLDELL 110
Cdd:cd17534    80 TAYSDEETLERAKETNPYGYLVKPFNERELK 110
pleD PRK09581
response regulator PleD; Reviewed
 1-118 5.07e-11

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 61.07  E-value: 5.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLeDDQLFN-ETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTT--PAI 77
Cdd:PRK09581    2 TARILVV-DDIPANvKLLEAKLLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKSDPATThiPVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1176161222  78 FLTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR 118
Cdd:PRK09581   81 MVTALDDPEDRVRGLEAGADDFLTKPINDVALFARVKSLTR 121
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
4-119 6.75e-11

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 60.81  E-value: 6.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:PRK10365    8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYS 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDelllRMQAVLRR 119
Cdd:PRK10365   88 SVETAVEALKTGALDYLIKPLDFD----NLQATLEK 119
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 3-115 4.40e-10

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 55.33  E-value: 4.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEE-EGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:cd19925     2 NVLIVEDDPMVAEIHRAYVEQvPGFTvIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQA 115
Cdd:cd19925    82 AANDVETVREALRLGVVDYLIKPFTFERLRQRLER 116
pleD PRK09581
response regulator PleD; Reviewed
 2-125 4.99e-10

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 58.37  E-value: 4.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEgYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFL 79
Cdd:PRK09581  156 GRILLVDDDVSQAERIANILKEE-FRVVVVSDPSEALFNAAETNYDLVIVSANFENYDPLRLCSQLRSKERTryVPILLL 234

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRmqavLRRQVRKER 125
Cdd:PRK09581  235 VDEDDDPRLVKALELGVNDYLMRPIDKNELLAR----VRTQIRRKR 276
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-128 5.56e-10

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 56.65  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIEC---ALDPYSALDLtykHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:COG4566     2 VYIVDDDEAVRDSLAFLLESAGLRVETfasAEAFLAALDP---DRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLT 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL-----RRQVRKERVDI 128
Cdd:COG4566    79 GHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALardraRRAERARRAEL 131
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 4-103 8.13e-10

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 54.09  E-value: 8.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSgDTTPAIFLTSRD 83
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLREW-SAVPVIVLSARD 79

                          90       100
                  ....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKP 103
Cdd:cd17620    80 EESDKIAALDAGADDYLTKP 99
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 3-56 1.06e-09

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 52.57  E-value: 1.06e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1176161222    3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLP 56
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 3-117 1.12e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 54.27  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGD--TTPAIFL 79
Cdd:cd19923     2 KVLVVDDFSTMRRIIKNLLKELGFNnVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGAlsHLPVLMV 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd19923    82 TAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKIF 119
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 4-108 1.55e-09

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 56.80  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:PRK10923    6 VWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHS 85

                          90       100
                  ....*....|....*....|....*
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDE 108
Cdd:PRK10923   86 DLDAAVSAYQQGAFDYLPKPFDIDE 110
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 4-103 2.69e-09

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 52.76  E-value: 2.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSG--DTTPAIFLTS 81
Cdd:cd17602     1 VACVDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSalKDTPIIMLTG 80

                          90       100
                  ....*....|....*....|..
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKP 103
Cdd:cd17602    81 KDGLVDRIRAKMAGASGYLTKP 102
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-125 3.28e-09

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 53.26  E-value: 3.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17549     1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLlrmqAVLRRQVRKER 125
Cdd:cd17549    81 DVPMAVEAMRAGAYDFLEKPFDPERLL----DVVRRALEKRR 118
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 1-212 1.34e-08

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 53.28  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:PRK13856    1 MKHVLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLR------RQVRKERVDIGKYSLDTVAKILYLEDKA-LDVTQKA 153
Cdd:PRK13856   81 DRLEEADKVVALELGATDFIAKPFGTREFLARIRVALRvrpnvvRTKDRRSFCFADWTLNLRQRRLISEAGGeVKLTAGE 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176161222 154 IELLVLLVQADGEVVSSDEIKNRLWAAGQSASDGSLRVYITQLKKYF------PEAISNVRGIGY 212
Cdd:PRK13856  161 FNLLVAFLEKPRDVLSREQLLIASRVREEEVYDRSIDVLILRLRRKLeqdpanPQLIKTARGAGY 225
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-116 1.37e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 51.26  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDD----QLFNETLE------------------DFLEEEGyTIECALDPysaldltykhvfDLYLFDVNLPYENG 60
Cdd:cd17557     1 TILLVEDNpgdaELIQEAFKeagvpnelhvvrdgeealDFLRGEG-EYADAPRP------------DLILLDLNMPRMDG 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161222  61 FDLLEKLRGSGDTT--PAIFLTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAV 116
Cdd:cd17557    68 FEVLREIKADPDLRriPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSL 125
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
 4-125 1.51e-08

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 51.16  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEgYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIFLTS 81
Cdd:cd17539     1 VLLVDDRPSSAERIAAMLSSE-HEVVVEADPDEALFRAAEGPFDLVIVSLALEDFDGLRLCSQLRSLERTrqLPILAVAD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELLLRmqavLRRQVRKER 125
Cdd:cd17539    80 PGDRGRLIRALEIGVNDYLVRPIDPNELLAR----VRTQIRRKR 119
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 3-109 3.45e-08

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 50.25  E-value: 3.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:cd17553     2 KILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAY 81

                          90       100
                  ....*....|....*....|....*..
gi 1176161222  83 DDKDSLTQGFSIGADDYMKKPIDLDEL 109
Cdd:cd17553    82 GELDMIQESKELGALTHFAKPFDIDEI 108
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 4-125 4.80e-08

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 49.84  E-value: 4.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIEC--ALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRgSGDTTPAI-FLT 80
Cdd:cd17532     1 ALIVDDEPLAREELRYLLEEHPDIEIVgeAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLS-KLAKPPLIvFVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1176161222  81 SRDdkDSLTQGFSIGADDYMKKPIDLDelllRMQAVLRRqVRKER 125
Cdd:cd17532    80 AYD--EYAVEAFELNAVDYLLKPFSEE----RLAEALAK-LRKRL 117
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 2-116 2.13e-07

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 49.64  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLE--------------EEGYTIECALDPysaldltykhvfDLYLFDVNLPYENGFDLLEKL 67
Cdd:PRK10651    7 ATILLIDDHPMLRTGVKQLISmapditvvgeasngEQGIELAESLDP------------DLILLDLNMPGMNGLETLDKL 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1176161222  68 RGSGDTTPAIFLTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAV 116
Cdd:PRK10651   75 REKSLSGRIVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQA 123
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
4-109 2.20e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.89  E-value: 2.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222    4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:PRK09959   961 ILIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANA 1040

                           90       100
                   ....*....|....*....|....*.
gi 1176161222   84 DKDSLTQGFSIGADDYMKKPIDLDEL 109
Cdd:PRK09959  1041 QANEREKGLSCGMNLCLFKPLTLDVL 1066
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 4-103 2.79e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 47.37  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYK---------HVFDLYLFDVNLPYENGFDLLEKLRGSG--D 72
Cdd:cd19924     1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEALNKLENlakegndlsKELDLIITDIEMPKMDGYELTFELRDDPrlA 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176161222  73 TTPAIFLTSRDDKDSLTQGFSIGADDYMKKP 103
Cdd:cd19924    81 NIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
PRK10610 PRK10610
chemotaxis protein CheY;
3-103 6.04e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 46.89  E-value: 6.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGY-TIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGD--TTPAIFL 79
Cdd:PRK10610    7 KFLVVDDFSTMRRIVRNLLKELGFnNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAmsALPVLMV 86

                          90       100
                  ....*....|....*....|....
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKP 103
Cdd:PRK10610   87 TAEAKKENIIAAAQAGASGYVVKP 110
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-80 6.87e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 46.19  E-value: 6.87e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKH-VFDLYLFDVNLPYE-NGFDLLEKLRGSGDTTPAIFLT 80
Cdd:cd18161     1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGpDIDLLVTDVIMPGGmNGSQLAEEARRRRPDLKVLLTS 79
PRK10693 PRK10693
two-component system response regulator RssB;
30-109 8.40e-07

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 48.45  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  30 CALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDDKDSLTQGFSIGADDYMKKPI-DLDE 108
Cdd:PRK10693    2 LAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKPVkDLNR 81


                  .
gi 1176161222 109 L 109
Cdd:PRK10693   82 L 82
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-67 1.07e-06

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 46.42  E-value: 1.07e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176161222   1 MARILVLEDDQLFNETLEDFLE-EEGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKL 67
Cdd:COG2197     1 MIRVLIVDDHPLVREGLRALLEaEPDIEvVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
139-214 1.75e-06

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 47.92  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222 139 ILYLEDKALDVTQKAIELLVLLVQADGEVVSSDEIKNRLWAAGQsASDGSLRVYITQLKKYFPEA-----ISNVRGIGYR 213
Cdd:PRK12370   26 SLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAE-VNEESLTRCIYALRRILSEDkehryIETLYGQGYR 104


                  .
gi 1176161222 214 W 214
Cdd:PRK12370  105 F 105
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-117 2.56e-06

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 44.89  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd17537     3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17537    83 DVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
3-125 6.78e-06

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 46.12  E-value: 6.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSR 82
Cdd:PRK10841  803 MILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGVTAN 882

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1176161222  83 ---DDKDSLTQGfsiGADDYMKKPIDLDeLLLRMQAVLRRQVRKER 125
Cdd:PRK10841  883 alaEEKQRCLEA---GMDSCLSKPVTLD-VLKQTLTVYAERVRKSR 924
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 3-117 7.29e-06

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 43.81  E-value: 7.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTI--EcALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:cd17542     2 KVLIVDDAAFMRMMLKDILTKAGYEVvgE-AANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVL 117
Cdd:cd17542    81 AMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 47-110 1.42e-05

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 42.72  E-value: 1.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176161222  47 DLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDDKDSLTQGFSIGADDYMKKPIDLDELL 110
Cdd:cd19931    46 DLILLDLNMKGMSGLDTLKALREEGVSARIVILTVSDAEDDVVTALRAGADGYLLKDMEPEDLL 109
PRK10430 PRK10430
two-component system response regulator DcuR;
46-103 1.48e-05

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 44.33  E-value: 1.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176161222  46 FDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDDKDSLTQGFSIGADDYMKKP 103
Cdd:PRK10430   50 IDLILLDIYMQQENGLDLLPVLHEAGCKSDVIVISSAADAATIKDSLHYGVVDYLIKP 107
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-109 3.87e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 43.67  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT- 80
Cdd:PRK15115    6 AHLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTa 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176161222  81 --SRDDKDSLTQGfsiGADDYMKKPIDLDEL 109
Cdd:PRK15115   86 hgSIPDAVAATQQ---GVFSFLTKPVDRDAL 113
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 3-122 4.16e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 41.61  E-value: 4.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYtIE---CALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDtTPAIFL 79
Cdd:cd17541     2 RVLIVDDSAVMRKLLSRILESDPD-IEvvgTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVMV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1176161222  80 TSRDDKDSLT--QGFSIGADDYMKKP-IDLDELLLRMQAVLRRQVR 122
Cdd:cd17541    80 SSLTEEGAEItlEALELGAVDFIAKPsGGISLDLEEIAEELIEKIK 125
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 3-111 5.66e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 41.23  E-value: 5.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRG-SGDTTpAIFLTS 81
Cdd:cd17569     2 TILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRErYPDTV-RILLTG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1176161222  82 RDDKDSLTQgfSIGADD---YMKKPIDLDELLL 111
Cdd:cd17569    81 YADLDAAIE--AINEGEiyrFLTKPWDDEELKE 111
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 4-110 8.56e-05

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 40.53  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGdtTPAIFLTSR 82
Cdd:cd17586     1 VLVLEDEPLIAMNLEDALEDLGGKeVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRRA--IPFIFATGY 78

                          90       100
                  ....*....|....*....|....*...
gi 1176161222  83 DDKDSLTQGFSigADDYMKKPIDLDELL 110
Cdd:cd17586    79 GDSHGIDSRLI--DVPVLRKPFDADSAL 104
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 4-113 9.78e-05

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 40.32  E-value: 9.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYT-IECALDPYSALDLTYKHVFDLYLFDVNL-PYENGFDLLEKLRGS---GDTTPAIF 78
Cdd:cd17589     1 FLIVDDQPTFRSMLKSMLRSLGVTrIDTASSGEEALRMCENKTYDIVLCDYNLgKGKNGQQLLEELRHKkliSPSTVFIM 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRM 113
Cdd:cd17589    81 VTGESSRAMVLSALELEPDDYLLKPFTVSELRERL 115
PRK13557 PRK13557
histidine kinase; Provisional
 3-117 1.13e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 42.35  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHV-FDLYLFDVNLPYE-NGFDLLEKLRgsgDTTPAI--F 78
Cdd:PRK13557  417 TILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHPeVDLLFTDLIMPGGmNGVMLAREAR---RRQPKIkvL 493

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1176161222  79 LTSRDDKDSLTQGFSIGAD-DYMKKPIDLDELLLRMQAVL 117
Cdd:PRK13557  494 LTTGYAEASIERTDAGGSEfDILNKPYRRAELARRVRMVL 533
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 4-103 1.15e-04

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 39.79  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd19928     1 ILVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQN 80

                          90       100
                  ....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKP 103
Cdd:cd19928    81 TLMTAVKAAERGAFEYLPKP 100
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
33-117 1.48e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 41.40  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222  33 DPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLR 112
Cdd:PRK09935   37 DYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHA 116


                  ....*
gi 1176161222 113 MQAVL 117
Cdd:PRK09935  117 VQMIL 121
fixJ PRK09390
response regulator FixJ; Provisional
 2-127 1.52e-04

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 41.14  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTS 81
Cdd:PRK09390    4 GVVHVVDDDEAMRDSLAFLLDSAGFEVRLFESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQAVLRRQVRKERVD 127
Cdd:PRK09390   84 HGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAKSE 129
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-115 1.98e-04

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 40.99  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGY--TIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:PRK10403    8 QVLIVDDHPLMRRGVRQLLELDPGfeVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILT 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQA 115
Cdd:PRK10403   88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA 122
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 3-109 2.53e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 41.46  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLR---GSGDTTPAIFL 79
Cdd:PRK11091  527 NILLVEDIELNVIVARSVLEKLGNSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELReryPREDLPPLVAL 606

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1176161222  80 TS--RDDKDSLtqgFSIGADDYMKKPIDLDEL 109
Cdd:PRK11091  607 TAnvLKDKKEY---LDAGMDDVLSKPLSVPAL 635
dpiA PRK10046
two-component response regulator DpiA; Provisional
 4-123 3.26e-04

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 40.39  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEE-EGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTS 81
Cdd:PRK10046    7 LLIVEDETPLAEMHAEYIRHiPGFSqILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVFTTA 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1176161222  82 RDDKDSLTQGFSIGADDYMKKPIDLDELllrMQAVLRRQVRK 123
Cdd:PRK10046   87 ASDMETVSEAVRCGVFDYLIKPIAYERL---GQTLTRFRQRK 125
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 3-112 3.71e-04

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 39.14  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLF----NETLEDFLEEEGYTIE-----CALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT 73
Cdd:cd17533     2 NIFILEDDKIQrvrlEEIIENILKIENIEYVieltgKTEELLEKIKERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDPY 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1176161222  74 TPAIFLTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLR 112
Cdd:cd17533    82 AIIIFVTTHSEFAPLTFEYKVAALDFILKPLKLEEFKKR 120
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 3-103 3.81e-04

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 38.74  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEE-EGYT-IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGS-GDTTPAIFL 79
Cdd:cd17561     3 KVLIADDNREFVQLLEEYLNSqPDMEvVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMrLEKRPKIIM 82

                          90       100
                  ....*....|....*....|....*
gi 1176161222  80 TSRDDKDSLTQ-GFSIGADDYMKKP 103
Cdd:cd17561    83 LTAFGQEDITQrAVELGASYYILKP 107
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
 4-103 5.84e-04

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 38.15  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDL--TYKHVFDLYLFDVNLPYENGFDLLEKLRGSGD--TTPAIFL 79
Cdd:cd17582     1 VLLVENDDSTRQIVTALLRKCSYEVTAASDGLQAWDVleDEQNEIDLILTEVDLPVSSGFKLLSYIMRHKIckNIPVIMM 80

                          90       100
                  ....*....|....*....|....
gi 1176161222  80 TSRDDKDSLTQGFSIGADDYMKKP 103
Cdd:cd17582    81 SSQDSVGVVFKCLSKGAADYLVKP 104
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 4-104 6.64e-04

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 38.02  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEE--GYTIECALDPYSALD-LTYKHVfDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:cd17565     1 FYIVDDDKNIIKILSDIIEDDdlGEVVGEADNGAQAYDeILFLQP-DIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMIS 79

                          90       100
                  ....*....|....*....|....
gi 1176161222  81 SRDDKDSLTQGFSIGADDYMKKPI 104
Cdd:cd17565    80 QVSDKEMIGKAYQAGIEFFINKPI 103
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 3-112 1.14e-03

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 37.50  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHV-FDLYLFDVNLPYENGFDLLEKLRGSGDTTP-AIFLT 80
Cdd:cd17544     2 KVLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLEQHPdIKLVITDYNMPEMDGFELVREIRKKYSRDQlAIIGI 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176161222  81 SRDDKDSLTQGFsI--GADDYMKKPIDLDELLLR 112
Cdd:cd17544    82 SASGDNALSARF-IkaGANDFLTKPFLPEEFYCR 114
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 37-109 1.65e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 37.13  E-value: 1.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176161222  37 ALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRDDKDSLTQGFSIGADDYMKKPIDLDEL 109
Cdd:cd17593    37 ALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVSGDVQPEAKERVLELGALAFLKKPFDPEKL 109
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 4-103 1.69e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 36.75  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd19926     1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYG 80

                          90       100
                  ....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKP 103
Cdd:cd19926    81 SLDTAIEALKAGAFDFLTKP 100
PRK14084 PRK14084
DNA-binding response regulator;
3-107 1.75e-03

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 38.19  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   3 RILVLEDDQLFNETLEDFLEEEGYT--IECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLT 80
Cdd:PRK14084    2 KALIVDDEPLARNELTYLLNEIGGFeeINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFAT 81

                          90       100
                  ....*....|....*....|....*..
gi 1176161222  81 SRDdkDSLTQGFSIGADDYMKKPIDLD 107
Cdd:PRK14084   82 AHD--QFAVKAFELNATDYILKPFEQK 106
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
5-115 2.08e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 37.95  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   5 LVLEDDQLFNETLEDFLEEEGYTIECALDP-YSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:PRK09958    4 IIIDDHPLAIAAIRNLLIKNDIEILAELTEgGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKN 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRMQA 115
Cdd:PRK09958   84 DHFYGKHCADAGANGFVSKKEGMNNIIAAIEA 115
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 2-114 2.10e-03

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 37.00  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   2 ARILVLEDDQLFNETLEDFL-EEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDT--TPAIF 78
Cdd:cd17575     1 IMVLLVDDQAIIGEAVRRALaDEEDIDFHYCSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATrdIPIIV 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1176161222  79 LTSRDDKDSLTQGFSIGADDYMKKPIDLDELLLRMQ 114
Cdd:cd17575    81 LSTKEEPEVKSEAFALGANDYLVKLPDKIELVARIR 116
PRK11697 PRK11697
two-component system response regulator BtsR;
1-125 2.41e-03

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 37.90  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   1 MARILVLEDDQLFNETLEDFLEEEG-YTI--ECAlDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLrgSGDTTPAI 77
Cdd:PRK11697    1 MIKVLIVDDEPLAREELRELLQEEGdIEIvgECS-NAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML--DPEHMPYI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1176161222  78 -FLTSRDDkdSLTQGFSIGADDYMKKPIDLDelllRMQAVLRRqVRKER 125
Cdd:PRK11697   78 vFVTAFDE--YAIKAFEEHAFDYLLKPIDPA----RLAKTLAR-LRQER 119
REC_RitR-like cd19922
receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus ...
 4-113 4.11e-03

receiver (REC) domain of orphan response regulator RitR and similar domains; Streptococcus pneumoniae RitR (Repressor of iron transport Regulator, formerly RR489) is an orphan two-component signal transduction response regulator that is required for lung pathogenicity. It acts to repress iron uptake via binding the pneumococcal iron uptake (Piu) transporter promoter. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. However, members of this family do not contain the phosphorylatable aspartic acid residue and are phosphorylation-independent.


Pssm-ID: 381149 [Multi-domain]  Cd Length: 110  Bit Score: 35.92  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176161222   4 ILVLEDDQLFNETLEDFLEEEGYTIECALDPYSALDLTYKHVFDLYLFDVNLPYENGFDLLEKLRGSGDTTPAIFLTSRD 83
Cdd:cd19922     1 ILLLEKERNLAHFLSLELQKEGYRVDLVETGQEALSLALETDYDLILLNVNLSDMSAQDFAEKLSRIKPASVIIVLDHWE 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176161222  84 DKDSLTQGFSIGADDYMKKPIDLDELLLRM 113
Cdd:cd19922    81 DLQEELEEVQRFAVSYVVKPVLISNLVDKI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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