NCBI Conserved Domain Search

Conserved domains on [gi|1176173637|gb|OQX88945|]

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hypothetical protein B6D60_00610 [candidate division KSB1 bacterium 4484_87]

Protein Classification

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

247-481

1.06e-84

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 260.99 E-value: 1.06e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 247 RDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLD-ENISSDQSREYSNIILKESRRLSELINKYLDISRIESGK 325
Cdd:COG2205     4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 326 SEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGN 405
Cdd:COG2205    84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637 406 EQIISVTDQGYGISENELERVFDKFYRATETvevQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG2205   164 GVRISVSDNGPGIPEEELERIFERFYRGDNS---RGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236

RocR super family

cl34674

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

138-286

3.08e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

The actual alignment was detected with superfamily member COG3829:

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 62.10 E-value: 3.08e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEkvksgtnSSEEKVEIEVTPE 217
Cdd:COG3829    11 EELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLK-------TGKPVTGVIQKTG 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173637 218 NQRQPIILQAIatkVISDNRKLFGVVIALRDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLD 286
Cdd:COG3829    84 GKGKTVIVTAI---PIFEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDIIGKSPAMKE 149

HAMP

cd06225

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...

81-116

4.20e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.

Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.81 E-value: 4.20e-04

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1176173637  81 IRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN 116
Cdd:cd06225     4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFN 39

Name

Accession

Description

Interval

E-value

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

247-481

1.06e-84

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 260.99 E-value: 1.06e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 247 RDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLD-ENISSDQSREYSNIILKESRRLSELINKYLDISRIESGK 325
Cdd:COG2205     4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 326 SEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGN 405
Cdd:COG2205    84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637 406 EQIISVTDQGYGISENELERVFDKFYRATETvevQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG2205   164 GVRISVSDNGPGIPEEELERIFERFYRGDNS---RGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236

PRK11360

two-component system sensor histidine kinase AtoS;

99-481

1.16e-53

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 190.18 E-value: 1.16e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  99 RIPvDAEDELGKFGKFFNMLTKEHHEIKKKNvgeklfewekiQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNY 178
Cdd:PRK11360  235 RLP-PLPGELGEISQAINNLAQALRETRSLN-----------ELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHEL 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 179 LSMELEKLIRDDKlkGLIEKVKSGTNSSEEKVEIEVTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRK 258
Cdd:PRK11360  303 VGKPYSELFPPNT--PFASPLLDTLEHGTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRR 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 259 KS---------EVVSMVSHELRSPLTSITGFSELLLDEnISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVH 329
Cdd:PRK11360  381 VArqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQ-TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQ 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 330 MTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGN-EQI 408
Cdd:PRK11360  456 WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVA 535

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176173637 409 ISVTDQGYGISENELERVFDKFY--RAtetvevqeeKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:PRK11360  536 VSIEDNGCGIDPELLKKIFDPFFttKA---------KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

249-477

1.35e-33

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 132.13 E-value: 1.35e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 249 LTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQSRE--YSNiiLKESRRLSELINKYLDISRIESGKS 326
Cdd:TIGR01386 231 LGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREvlESN--LEELERLSRMVSDMLFLARADNGQL 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 327 EVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRfpeKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNE 406
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDE 385

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173637 407 QIISVTDQGYGISENELERVFDKFYRATETVEVQEEkGTGLGLALVREIITKHHGRVWVTSklKQGSTFFI 477
Cdd:TIGR01386 386 VRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGE-GTGLGLAIVRSIMEAHGGRASAES--PDGKTRFI 453

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

370-481

1.08e-32

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 120.45 E-value: 1.08e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  370 ADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETveVQEEKGTGLGL 449
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKR--SRKIGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1176173637  450 ALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

370-480

4.76e-28

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.45 E-value: 4.76e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 370 ADRQMMGEVILNLFSNAVKYSPADTTVTISIEEtGNEQIISVTDQGYGISENELERVFDKFYRATETvevqEEKGTGLGL 449
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKR----GGGGTGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176173637 450 ALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:pfam02518  76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-480

1.53e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 100.48 E-value: 1.53e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYSPADTT--VTISIEETGNEQIISVTDQGYGISENELERVFDKFYRatetVEVQEE-KGTGLGLAL 451
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQR----LHSREEyEGTGVGLAI 76

                          90       100
                  ....*....|....*....|....*....
gi 1176173637 452 VREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16921    77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

138-286

3.08e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 62.10 E-value: 3.08e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEkvksgtnSSEEKVEIEVTPE 217
Cdd:COG3829    11 EELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLK-------TGKPVTGVIQKTG 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173637 218 NQRQPIILQAIatkVISDNRKLFGVVIALRDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLD 286
Cdd:COG3829    84 GKGKTVIVTAI---PIFEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDIIGKSPAMKE 149

HAMP

cd06225

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...

81-116

4.20e-04

Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.81 E-value: 4.20e-04

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1176173637  81 IRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN 116
Cdd:cd06225     4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFN 39

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

138-204

4.93e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 38.53 E-value: 4.93e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637  138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGTN 204
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

138-248

7.30e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 39.32 E-value: 7.30e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIR---DDKLKGLIEKVKSGTNSSEEkVEIEV 214
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPeedDAEVAELLRQALLQGEESRG-FEVSF 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176173637 215 TPENQRqPIILQAIATKVISDNRKLFGVVIALRD 248
Cdd:pfam00989  80 RVPDGR-PRHVEVRASPVRDAGGEILGFLGVLRD 112

PAS

cd00130

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

147-249

7.56e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 39.15 E-value: 7.56e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 147 IGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSG-TNSSEEKVEIEVTPENqRQPIIL 225
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLlSGGEPVTLEVRLRRKD-GSVIWV 79

                          90       100
                  ....*....|....*....|....
gi 1176173637 226 QAIATKVISDNRKLFGVVIALRDL 249
Cdd:cd00130    80 LVSLTPIRDEGGEVIGLLGVVRDI 103

NarQ

COG3850

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...

51-116

2.49e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];

Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 40.25 E-value: 2.49e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637  51 NFWFFIIILAISLSLSALTTRVLCSSFYERIRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN 116
Cdd:COG3850   116 NRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFN 181

HAMP

smart00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

79-120

4.09e-03

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 35.30 E-value: 4.09e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1176173637   79 ERIRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN-MLTK 120
Cdd:smart00304   5 RPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNeMADR 47

PRK09776

putative diguanylate cyclase; Provisional

128-260

5.85e-03

putative diguanylate cyclase; Provisional

Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 39.27 E-value: 5.85e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  128 KNVGEKLF-EWEKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIR-DDKLKG-LIEKVKSG-T 203
Cdd:PRK09776   525 RQLNEALFqEKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHiTFGDNGpLMENIYSClT 604

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  204 NSSEEKVEIEVTPEN---QRQPIilQAIATKVISDNRKLFGVVIALRDLTREKEIDRKKS 260
Cdd:PRK09776   605 SRSAAYLEQDVVLHCrsgGSYDV--HYSITPLSTLDGENIGSVLVIQDVTESRKMLRQLS 662

Name

Accession

Description

Interval

E-value

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

247-481

1.06e-84

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 260.99 E-value: 1.06e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 247 RDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLD-ENISSDQSREYSNIILKESRRLSELINKYLDISRIESGK 325
Cdd:COG2205     4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 326 SEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGN 405
Cdd:COG2205    84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637 406 EQIISVTDQGYGISENELERVFDKFYRATETvevQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG2205   164 GVRISVSDNGPGIPEEELERIFERFYRGDNS---RGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

134-483

4.26e-84

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 264.88 E-value: 4.26e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 134 LFEWEKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGTNSSEEKVEIE 213
Cdd:COG5002    40 LLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 214 VTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDENI-SSD 292
Cdd:COG5002   120 LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAAdDPE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 293 QSREYSNIILKESRRLSELINKYLDISRIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADR 372
Cdd:COG5002   200 ERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDP 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 373 QMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRAtETVEVQEEKGTGLGLALV 452
Cdd:COG5002   280 DRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRV-DKSRSRETGGTGLGLAIV 358

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1176173637 453 REIITKHHGRVWVTSKLKQGSTFFIALPIMQ 483
Cdd:COG5002   359 KHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

211-481

1.30e-76

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 243.28 E-value: 1.30e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 211 EIEVTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDEniS 290
Cdd:COG0642    62 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE--L 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 291 SDQSREYSNIILKESRRLSELINKYLDISRIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINA 370
Cdd:COG0642   140 DEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRG 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 371 DRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVevqEEKGTGLGLA 450
Cdd:COG0642   220 DPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSR---RGGGTGLGLA 296

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1176173637 451 LVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG0642   297 IVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

54-486

1.16e-74

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 241.40 E-value: 1.16e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  54 FFIIILAISLSLSALTTRVLCSSFYERI-RTYNQIA---RKIAGGQFELRIPVDAEDELGKFGKFFNMLTKEHHEIKKKN 129
Cdd:COG5000     6 LFLLLLLLIALLLLLLALWLALLLARRLtRPLRRLAeatRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 130 VGEKLFewekIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGtnssEEK 209
Cdd:COG5000    86 EERRRY----LETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALER----GWQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 210 VEIEVTPENQRqpiILQAIATKVISDnrklfGVVIALRDLTREKEIDRKKS--EVVSMVSHELRSPLTSITGFSELL--- 284
Cdd:COG5000   158 EEIELTRDGRR---TLLVRASPLRDD-----GYVIVFDDITELLRAERLAAwgELARRIAHEIKNPLTPIQLSAERLrrk 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 285 LDENISSDQS--REYSNIILKESRRLSELINKYLDISRIesgkSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFP 362
Cdd:COG5000   230 LADKLEEDREdlERALDTIIRQVDRLKRIVDEFLDFARL----PEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLD 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 363 EKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFY--Ratetvevq 440
Cdd:COG5000   306 PDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFttK-------- 377

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1176173637 441 eEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQRED 486
Cdd:COG5000   378 -PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

138-486

3.56e-65

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 214.71 E-value: 3.56e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIR-DDKLKGLIEKV-KSGTNSSEEKVEIeVT 215
Cdd:COG3852     7 ELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPeDSPLRELLERAlAEGQPVTEREVTL-RR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 216 PENQRQPIILQAIAtkvISDNRKLFGVVIALRDLTREKEIDRKK---------SEVVSMVSHELRSPLTSITGFSELLLD 286
Cdd:COG3852    86 KDGEERPVDVSVSP---LRDAEGEGGVLLVLRDITERKRLERELrraeklaavGELAAGLAHEIRNPLTGIRGAAQLLER 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 287 EnISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVHMTPLTMDDVIQSVVSMnAFLASSKNIQVKLRFPEKIS 366
Cdd:COG3852   163 E-LPDDELREYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLEL-LRAEAPKNIRIVRDYDPSLP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 367 SINADRQMMGEVILNLFSNAVKYSPADTTVTISIE----------ETGNEQIISVTDQGYGISENELERVFDKFY--Rat 434
Cdd:COG3852   237 EVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqvtlgglRPRLYVRIEVIDNGPGIPEEILDRIFEPFFttK-- 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1176173637 435 etvevqeEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQRED 486
Cdd:COG3852   315 -------EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359

PRK11360

two-component system sensor histidine kinase AtoS;

99-481

1.16e-53

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 190.18 E-value: 1.16e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  99 RIPvDAEDELGKFGKFFNMLTKEHHEIKKKNvgeklfewekiQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNY 178
Cdd:PRK11360  235 RLP-PLPGELGEISQAINNLAQALRETRSLN-----------ELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHEL 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 179 LSMELEKLIRDDKlkGLIEKVKSGTNSSEEKVEIEVTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRK 258
Cdd:PRK11360  303 VGKPYSELFPPNT--PFASPLLDTLEHGTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRR 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 259 KS---------EVVSMVSHELRSPLTSITGFSELLLDEnISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVH 329
Cdd:PRK11360  381 VArqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQ-TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQ 455

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 330 MTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGN-EQI 408
Cdd:PRK11360  456 WQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVA 535

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176173637 409 ISVTDQGYGISENELERVFDKFY--RAtetvevqeeKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:PRK11360  536 VSIEDNGCGIDPELLKKIFDPFFttKA---------KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

126-485

1.94e-51

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 181.71 E-value: 1.94e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 126 KKKNVGEKLFEWE-KIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKlKGLIEKVKSGTN 204
Cdd:COG5809   128 ERKRMEEALRESEeKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDD-QENVAAFISQLL 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 205 SSEEKVEIEVTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRK--KSEVVSMV-------SHELRSPLT 275
Cdd:COG5809   207 KDGGIAQGEVRFWTKDGRWRLLEASGAPIKKNGEVDGIVIIFRDITERKKLEELlrKSEKLSVVgelaagiAHEIRNPLT 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 276 SITGFSELLLDeNISSDQsREYSNIILKESRRLSELINKYLDISRIEsgksEVHMTPLTMDDVIQSVVS-MNAfLASSKN 354
Cdd:COG5809   287 SLKGFIQLLKD-TIDEEQ-KTYLDIMLSELDRIESIISEFLVLAKPQ----AIKYEPKDLNTLIEEVIPlLQP-QALLKN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 355 IQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQI-ISVTDQGYGISENELERVFDKFYra 433
Cdd:COG5809   360 VQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVvISVTDEGCGIPEERLKKLGEPFY-- 437

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1176173637 434 tetveVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQRE 485
Cdd:COG5809   438 -----TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSE 484

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

182-484

1.59e-50

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 179.60 E-value: 1.59e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 182 ELEKLIRDDKLKGLIEKVKSGTNSSEEKVEIEVTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTRE-KEIDRKKS 260
Cdd:COG4251   204 RLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAElERSNEELE 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 261 EVVSMVSHELRSPLTSITGFSELLLDENIS--SDQSREYSNIILKESRRLSELINKYLDISRIesGKSEVHMTPLTMDDV 338
Cdd:COG4251   284 QFAYVASHDLREPLRKISGFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAYSRV--GRQELEFEPVDLNEL 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 339 IQSVVSMNAFLASSKNIQVKLrfpEKISSINADRQMMGEVILNLFSNAVKYSPADTT--VTISIEETGNEQIISVTDQGY 416
Cdd:COG4251   362 LEEVLEDLEPRIEERGAEIEV---GPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGI 438

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176173637 417 GISENELERVFDKFYRATETvevQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQR 484
Cdd:COG4251   439 GIDPEYAEKIFEIFQRLHSR---DEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

261-481

1.50e-48

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 170.75 E-value: 1.50e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 261 EVVSMVSHELRSPLTSITGFSELL---LDENISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVHMTPLTMDD 337
Cdd:COG4191   144 ELAAGIAHEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSR----RDEEEREPVDLNE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 338 VIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAV-----KYSPadtTVTISIEETGNEQIISVT 412
Cdd:COG4191   220 LIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIdameeGEGG---RITISTRREGDYVVISVR 296

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173637 413 DQGYGISENELERVFDKFYraTeTVEVQeeKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG4191   297 DNGPGIPPEVLERIFEPFF--T-TKPVG--KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360

PRK11100

sensory histidine kinase CreC; Provisional

246-463

6.22e-43

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 158.47 E-value: 6.22e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 246 LRDLTREKEIDRKKSE-------VVSMVSHELRSPLTSITGFSELLlDENISSDQSREYSNIILKESRRLSELINKYLDI 318
Cdd:PRK11100  236 LRELAQALESMRVKLEgkayveqYVQTLTHELKSPLAAIRGAAELL-QEDPPPEDRARFTGNILTQSARLQQLIDRLLEL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 319 SRIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEkiSSINADRQMMGEVILNLFSNAVKYSPADTTVTI 398
Cdd:PRK11100  315 ARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDD--ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITL 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176173637 399 SIEETGNEQIISVTDQGYGISENELERVFDKFY---RATetvevQEEKGTGLGLALVREIITKHHGRV 463
Cdd:PRK11100  393 SAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPA-----NGRKSTGLGLAFVREVARLHGGEV 455

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

138-481

1.70e-42

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 157.59 E-value: 1.70e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGTNSSEEKVEIEVTPE 217
Cdd:COG5805   157 ERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREIIT 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 218 NQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDR--KKSEVVSMV-------SHELRSPLTSITGFSELLLden 288
Cdd:COG5805   237 KDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEElmARSEKLSIAgqlaagiAHEIRNPLTSIKGFLQLLQ--- 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 289 ISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSI 368
Cdd:COG5805   314 PGIEDKEEYFDIMLSELDRIESIISEFLALAK----PQAVNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFI 389

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 369 NADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYratetveVQEEKGTGLG 448
Cdd:COG5805   390 YCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF-------TTKEKGTGLG 462

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1176173637 449 LALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG5805   463 LMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495

PRK10364

two-component system sensor histidine kinase ZraS;

252-486

2.47e-40

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 151.09 E-value: 2.47e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 252 EKEIDRKKsEVVSM------VSHELRSPLTSITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDISRiesgK 325
Cdd:PRK10364  225 QDEMKRKE-KLVALghlaagVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVK----P 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 326 SEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGN 405
Cdd:PRK10364  300 THLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 406 EQIISVTDQGYGISENELERVFDKFYrateTVEVQeekGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI-MQR 484
Cdd:PRK10364  380 GVKISVTDSGKGIAADQLEAIFTPYF----TTKAE---GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVnITR 452


                  ..
gi 1176173637 485 ED 486
Cdd:PRK10364  453 RD 454

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

260-480

2.75e-35

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 136.15 E-value: 2.75e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 260 SEVVSMVSHELRSPLTSITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDISRIESGKSEvhmtPLTMDDVI 339
Cdd:COG5806   202 SELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKLE----KIDVSEEL 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 340 QSVVSMNAFLASSKNIQVKLRFPEKIsSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGIS 419
Cdd:COG5806   278 EHVIDVLSPYANMNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMT 356

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173637 420 ENELERVFDKFYRATetvevqeEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:COG5806   357 KEQLERLGEPYFSTK-------EKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410

cztS_silS_copS

TIGR01386

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...

249-477

1.35e-33

Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 132.13 E-value: 1.35e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 249 LTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQSRE--YSNiiLKESRRLSELINKYLDISRIESGKS 326
Cdd:TIGR01386 231 LGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREvlESN--LEELERLSRMVSDMLFLARADNGQL 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 327 EVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRfpeKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNE 406
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDE 385

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173637 407 QIISVTDQGYGISENELERVFDKFYRATETVEVQEEkGTGLGLALVREIITKHHGRVWVTSklKQGSTFFI 477
Cdd:TIGR01386 386 VRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGE-GTGLGLAIVRSIMEAHGGRASAES--PDGKTRFI 453

PRK09303

histidine kinase;

249-483

2.86e-33

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 129.69 E-value: 2.86e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 249 LTREKE--IDRKKSE--VVSMVSHELRSPLTSITGFSELLLDENISSDQSREYSNI--ILKESRRLSELINKYL-DISRI 321
Cdd:PRK09303  137 LRQENEtlLEQLKFKdrVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIeqLQDQARRQLEEIERLItDLLEV 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 322 ESGKSE---VHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTI 398
Cdd:PRK09303  217 GRTRWEalrFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITL 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 399 SIEETGNEQI-ISVTDQGYGISENELERVFDKFYRATETvevQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFI 477
Cdd:PRK09303  297 SMLHRTTQKVqVSICDTGPGIPEEEQERIFEDRVRLPRD---EGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHF 373


                  ....*.
gi 1176173637 478 ALPIMQ 483
Cdd:PRK09303  374 TLPVYR 379

PRK10490

sensor protein KdpD; Provisional

216-480

4.84e-33

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 133.24 E-value: 4.84e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 216 PENQRqpiILQAiatkvisdnrklFGVVI--ALR--DLTREKEIDRKKSE-------VVSMVSHELRSPLTSITGFSELL 284
Cdd:PRK10490  625 PEQQR---LLET------------FTLLIanALErlTLTASEEQARLASEreqlrnaLLAALSHDLRTPLTVLFGQAEIL 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 285 -LDenISSDQS---REYSNI---ILKESRrlseLINKYLDISRIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQV 357
Cdd:PRK10490  690 tLD--LASEGSphaRQASEIrqqVLNTTR----LVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINL 763

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 358 KLrfPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETV 437
Cdd:PRK10490  764 SL--PEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKES 841

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1176173637 438 EVqeeKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:PRK10490  842 AI---PGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

370-481

1.08e-32

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 120.45 E-value: 1.08e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  370 ADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETveVQEEKGTGLGL 449
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKR--SRKIGGTGLGL 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1176173637  450 ALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:smart00387  79 SIVKKLVELHGGEISVESEPGGGTTFTITLPL 110

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

266-480

3.89e-31

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 125.65 E-value: 3.89e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 266 VSHELRSPLTSITGFSELLLDENISSDQSRE--YSNiiLKESRRLSELINKYLDISRIESGKSEVHMTPLTMDDVIQSVV 343
Cdd:PRK09835  269 IAHEIRTPITNLITQTEIALSQSRSQKELEDvlYSN--LEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVF 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 344 SMnaFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENEL 423
Cdd:PRK09835  347 DF--FEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHL 424

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637 424 ERVFDKFYRATETVEVQEEkGTGLGLALVREIITKHHGRVWVTSKLKqGSTFFIALP 480
Cdd:PRK09835  425 PRLFDRFYRVDPSRQRKGE-GSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISLP 479

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

370-480

4.76e-28

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.45 E-value: 4.76e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 370 ADRQMMGEVILNLFSNAVKYSPADTTVTISIEEtGNEQIISVTDQGYGISENELERVFDKFYRATETvevqEEKGTGLGL 449
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKR----GGGGTGLGL 75

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176173637 450 ALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:pfam02518  76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106

PRK15347

two component system sensor kinase;

247-481

2.78e-27

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 115.89 E-value: 2.78e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 247 RDLTREKEI----DRKKSEVVSMVSHELRSPLTSITGFSELLldENISSDQS-REYSNIILKESRRLSELINKYLDISRI 321
Cdd:PRK15347  382 QALAEAKQRaeqaNKRKSEHLTTISHEIRTPLNGVLGALELL--QNTPLTAEqMDLADTARQCTLSLLAIINNLLDFSRI 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 322 ESGKSEVHM--TPL--TMDDVIQSVVSMnaflASSKNIQ----VKLRFPEKISSinaDRQMMGEVILNLFSNAVKYSPaD 393
Cdd:PRK15347  460 ESGQMTLSLeeTALlpLLDQAMLTIQGP----AQSKSLTlrtfVGAHVPLYLHL---DSLRLRQILVNLLGNAVKFTE-T 531

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 394 TTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETvevqeEKGTGLGLALVREIITKHHGRVWVTSKLKQGS 473
Cdd:PRK15347  532 GGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH-----SQGTGLGLTIASSLAKMMGGELTLFSTPGVGS 606


                  ....*...
gi 1176173637 474 TFFIALPI 481
Cdd:PRK15347  607 CFSLVLPL 614

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

247-480

4.09e-27

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 113.18 E-value: 4.09e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 247 RDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDISRIESGKS 326
Cdd:PRK11006  192 RDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPT 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 327 evhmtpLTMDDVIQ-----SVVSMNAFLASSKNIQVKLRFPEKISSINADRQMMgEVILNLFSNAVKYSPADTTVTISIE 401
Cdd:PRK11006  272 ------IDLNEKVDvpmmlRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLR-SAISNLVYNAVNHTPEGTHITVRWQ 344

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173637 402 ETGNEQIISVTDQGYGISENELERVFDKFYRaTETVEVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:PRK11006  345 RVPQGAEFSVEDNGPGIAPEHIPRLTERFYR-VDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

247-480

4.27e-27

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 115.04 E-value: 4.27e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 247 RDLTREKEID-------RKKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQsREYSNIILKESRRLSELINKYLDIS 319
Cdd:PRK11091  264 RDITERKRYQdalekasRDKTTFISTISHELRTPLNGIVGLSRILLDTELTAEQ-RKYLKTIHVSAITLGNIFNDIIDMD 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 320 RIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLR----FPEKISsinADRQMMGEVILNLFSNAVKYSPaDTT 395
Cdd:PRK11091  343 KMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEpllpLPHKVI---TDGTRLRQILWNLISNAVKFTQ-QGG 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 396 VTISIE-ETGNEQIISVTDQGYGISENELERVFDKFYRATETVEVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGST 474
Cdd:PRK11091  419 VTVRVRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSC 498


                  ....*.
gi 1176173637 475 FFIALP 480
Cdd:PRK11091  499 FTLTIH 504

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

138-481

6.36e-27

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 111.86 E-value: 6.36e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTrqnylsmeleklIRDDKLKGLIEKVKSGTNSSEEKVEIEVTPE 217
Cdd:COG3290    84 EEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD------------AIGRPIDEVLAEVLETGERDEEILLNGRVLV 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 218 NQRQPIIlqaiatkvisDNRKLFGVVIALRDLT----REKEID--RKKSEVVSMVSHELRSPLTSITGFSELLldeniSS 291
Cdd:COG3290   152 VNRVPIR----------DDGRVVGAVATFRDRTelerLEEELEgvKELAEALRAQRHDFRNHLHTISGLLQLG-----EY 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 292 DQSREYsniILKESRRLSELINKylDISRIEsgksevhmtpltmDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINAD 371
Cdd:COG3290   217 DEALEY---IDEISEELQELIDS--LLSRIG-------------NPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLS 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 372 RQMMGEVILNLFSNAV----KYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYratETvevQEEKGTGL 447
Cdd:COG3290   279 DTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGF---ST---KLGEGRGL 352

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1176173637 448 GLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:COG3290   353 GLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386

PRK13837

two-component system VirA-like sensor kinase;

264-485

9.73e-27

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 114.39 E-value: 9.73e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 264 SMVSHELRSPLTSITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVHMTPLTMDDVIQSVV 343
Cdd:PRK13837  455 SGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGR----KGERNTKPFDLSELVTEIA 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 344 SMnafLASS--KNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEE---------------TGNE 406
Cdd:PRK13837  531 PL---LRVSlpPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlshgvlpPGRY 607

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 407 QIISVTDQGYGISENELERVFDKFY--RAtetvevqeeKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQR 484
Cdd:PRK13837  608 VLLRVSDTGAGIDEAVLPHIFEPFFttRA---------GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSK 678


                  .
gi 1176173637 485 E 485
Cdd:PRK13837  679 V 679

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-480

1.53e-25

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 100.48 E-value: 1.53e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYSPADTT--VTISIEETGNEQIISVTDQGYGISENELERVFDKFYRatetVEVQEE-KGTGLGLAL 451
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQR----LHSREEyEGTGVGLAI 76

                          90       100
                  ....*....|....*....|....*....
gi 1176173637 452 VREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16921    77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105

PRK09959

acid-sensing system histidine kinase EvgS;

247-481

4.16e-25

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 109.44 E-value: 4.16e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  247 RDLTREKEIDRKK--------SEVVSMVSHELRSPLTSITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDI 318
Cdd:PRK09959   692 RDLIHALEVERNKainatvakSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDV 771

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  319 SRIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLR--FPEKIsSINADRQMMGEVILNLFSNAVKYSPAD--- 393
Cdd:PRK09959   772 DKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSstFPDHY-LVKIDPQAFKQVLSNLLSNALKFTTEGavk 850

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  394 -TTVTISIEETGNEQIISVTDQGYGISENELERVFDKFyraTETVEVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQG 472
Cdd:PRK09959   851 iTTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRY---SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIG 927


                   ....*....
gi 1176173637  473 STFFIALPI 481
Cdd:PRK09959   928 TTFTITIPV 936

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

263-464

6.35e-24

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 104.24 E-value: 6.35e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 263 VSMVSHELRSPLTSITGFSELLLDEN-ISSDQSReysniILKESRRLSELINKYLDISRIESgKSEVHMTPLTMDDVIQS 341
Cdd:PRK09470  247 LSDISHELRTPLTRLQLATALLRRRQgESKELER-----IETEAQRLDSMINDLLVLSRNQQ-KNHLERETFKANSLWSE 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 342 VVSMNAFLASSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSpaDTTVTISIEETGNEQIISVTDQGYGISEN 421
Cdd:PRK09470  321 VLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEE 398

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1176173637 422 ELERVFDKFYRaTETVEVQEEKGTGLGLALVREIITKHHGRVW 464
Cdd:PRK09470  399 EREQIFRPFYR-VDEARDRESGGTGLGLAIVENAIQQHRGWVK 440

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

381-480

2.54e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 91.62 E-value: 2.54e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 381 NLFSNAVKYSPadTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVEvQEEKGTGLGLALVREIITKHH 460
Cdd:cd16949     7 NVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARD-RESGGTGLGLAIAERAIEQHG 83

                          90       100
                  ....*....|....*....|
gi 1176173637 461 GRVWVTSKLKQGSTFFIALP 480
Cdd:cd16949    84 GKIKASNRKPGGLRVRIWLP 103

PRK11107

hybrid sensory histidine kinase BarA; Provisional

251-481

4.75e-22

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 99.92 E-value: 4.75e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 251 REKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQsREYSNIILKESRRLSELINKYLDISRIESGKSEVHM 330
Cdd:PRK11107  285 RAQEAARIKSEFLANMSHELRTPLNGVIGFTRQTLKTPLTPTQ-RDYLQTIERSANNLLAIINDILDFSKLEAGKLVLEN 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 331 TPLTMDDVIQSVVSMNAFLASSKN----IQVKLRFPEkisSINADRQMMGEVILNLFSNAVKYSPADtTVTISIEETG-- 404
Cdd:PRK11107  364 IPFSLRETLDEVVTLLAHSAHEKGleltLNIDPDVPD---NVIGDPLRLQQIITNLVGNAIKFTESG-NIDILVELRAls 439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 405 NEQI---ISVTDQGYGISENELERVFDKFYRATETVEVQeEKGTGLGLalvreIITKH-----HGRVWVTSKLKQGSTFF 476
Cdd:PRK11107  440 NTKVqleVQIRDTGIGISERQQSQLFQAFRQADASISRR-HGGTGLGL-----VITQKlvnemGGDISFHSQPNRGSTFW 513


                  ....*
gi 1176173637 477 IALPI 481
Cdd:PRK11107  514 FHLPL 518

PRK10337

sensor protein QseC; Provisional

264-463

8.27e-22

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 97.80 E-value: 8.27e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 264 SMVSHELRSPLTSI---TGFSELLLDEnissDQSREYSNIILKES-RRLSELINKYLDISRIESGKSEVHMTPLTMDDVI 339
Cdd:PRK10337  242 SDAAHELRSPLAALkvqTEVAQLSDDD----PQARKKALLQLHAGiDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 340 QSVVSMNAFLASSKNIQVKLrfpekisSINAD---RQmmGEVIL------NLFSNAVKYSPADTTVTISIeetgNEQIIS 410
Cdd:PRK10337  318 QSAVMDIYHTAQQAGIDVRL-------TLNAHpviRT--GQPLLlsllvrNLLDNAIRYSPQGSVVDVTL----NARNFT 384

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1176173637 411 VTDQGYGISENELERVFDKFYRATEtvevQEEKGTGLGLALVREIITKHHGRV 463
Cdd:PRK10337  385 VRDNGPGVTPEALARIGERFYRPPG----QEATGSGLGLSIVRRIAKLHGMNV 433

PRK11466

hybrid sensory histidine kinase TorS; Provisional

226-481

2.66e-21

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 97.67 E-value: 2.66e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 226 QAIATKVISDNRKLFGVVIALRDLTREKE-IDRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSdQSREYSNIILKE 304
Cdd:PRK11466  410 EQLAAQVKARTAELQELVIEHRQARAEAEkASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALN-AQRDDLRAITDS 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 305 SRRLSELINKYLDISRIESGKSEVHMT--PLTMDDVIQSVVSmnafLASSKNIQVKLRFPEKI-----SSINADRQMMGE 377
Cdd:PRK11466  489 GESLLTILNDILDYSAIEAGGKNVSVSdePFEPRPLLESTLQ----LMSGRVKGRPIRLATDIaddlpTALMGDPRRIRQ 564

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 378 VILNLFSNAVKYSpADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATetvevQEEKGTGLGLALVREIIT 457
Cdd:PRK11466  565 VITNLLSNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVS-----GKRGGTGLGLTISSRLAQ 638

                         250       260
                  ....*....|....*....|....
gi 1176173637 458 KHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:PRK11466  639 AMGGELSATSTPEVGSCFCLRLPL 662

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

375-480

3.56e-21

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 88.32 E-value: 3.56e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYSPADT-TVTISIEETGNEQI---ISVTDQGYGISENELERVFDKFYRAtETVEVQEEKGTGLGLA 450
Cdd:cd16922     1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGVqlrFSVEDTGIGIPEEQQARLFEPFSQA-DSSTTRKYGGTGLGLA 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176173637 451 LVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16922    80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

370-472

1.43e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 86.69 E-value: 1.43e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 370 ADRQMMGEVIL------NLFSNAVKYSPADTTVTISIEETGNEQIIsVTDQGYGISENELERVFDKFYRAtetvEVQEEK 443
Cdd:cd16940     3 ADIQVQGDALLlflllrNLVDNAVRYSPQGSRVEIKLSADDGAVIR-VEDNGPGIDEEELEALFERFYRS----DGQNYG 77

                          90       100
                  ....*....|....*....|....*....
gi 1176173637 444 GTGLGLALVREIITKHHGRVWVTSKLKQG 472
Cdd:cd16940    78 GSGLGLSIVKRIVELHGGQIFLGNAQGGG 106

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

372-481

3.15e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 85.55 E-value: 3.15e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 372 RQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYrATETVEvqeeKGTGLGLAL 451
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-TTKPVG----EGTGLGLSL 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176173637 452 VREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:cd16943    76 SYRIIQKHGGTIRVASVPGGGTRFTIILPI 105

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

377-480

1.10e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 81.29 E-value: 1.10e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 377 EVILNLFSNAVKY------SPADTTVTISIEETGnEQIISVTDQGYGISENELERVFDKFYrateTVEVQeekGTGLGLA 450
Cdd:cd16920     3 QVLINLVRNGIEAmseggcERRELTIRTSPADDR-AVTISVKDTGPGIAEEVAGQLFDPFY----TTKSE---GLGMGLS 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176173637 451 LVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16920    75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

371-480

5.57e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 79.25 E-value: 5.57e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 371 DRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYraTETVEVQEEKGTGLGLA 450
Cdd:cd16948     2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF--TGENGRNFQESTGMGLY 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1176173637 451 LVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16948    80 LVKKLCDKLGHKIDVESEVGEGTTFTITFP 109

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

379-480

9.15e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 78.78 E-value: 9.15e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 379 ILNLFSNAVKYSPADTTVTI--SIEETGNEqiISVTDQGYGISENELERVFDKFYRaTETVEVQEEKGTGLGLALVREII 456
Cdd:cd16952     5 FSNLVSNAVKYTPPSDTITVrwSQEESGAR--LSVEDTGPGIPPEHIPRLTERFYR-VDIERCRNTGGTGLGLAIVKHVM 81

                          90       100
                  ....*....|....*....|....
gi 1176173637 457 TKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16952    82 SRHDARLLIASELGKGSRFTCLFP 105

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

258-324

1.03e-17

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 77.25 E-value: 1.03e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637 258 KKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQsREYSNIILKESRRLSELINKYLDISRIESG 324
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQ-REYLETILRSAERLLRLINDLLDLSRIEAG 66

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

371-480

1.37e-17

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 78.30 E-value: 1.37e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 371 DRQMMGEVILNLFSNAVKYSPADTTVTISIEET-GNEQIISVTDQGYGISENELERVFDKFYRATETvEVQEEKGTGLGL 449
Cdd:cd16925     1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGS-STRAHGGTGLGL 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176173637 450 ALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16925    80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

258-324

4.29e-17

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 75.30 E-value: 4.29e-17

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637  258 KKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQsREYSNIILKESRRLSELINKYLDISRIESG 324
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIEAG 66

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

256-320

9.78e-17

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 74.17 E-value: 9.78e-17

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176173637 256 DRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDISR 320
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65

envZ

PRK09467

osmolarity sensor protein; Provisional

266-481

1.69e-16

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 81.50 E-value: 1.69e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 266 VSHELRSPLTSITGFSELLLDENissdqsrEYsniiLKES-----RRLSELINKYLDISRieSGKSEVhMTPLTMDDVIQ 340
Cdd:PRK09467  236 VSHDLRTPLTRIRLATEMMSEED-------GY----LAESinkdiEECNAIIEQFIDYLR--TGQEMP-MEMADLNALLG 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 341 SVVSMNaflaSSKNIQVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADttVTISIEETGNEQIISVTDQGYGISE 420
Cdd:PRK09467  302 EVIAAE----SGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGW--IKVSSGTEGKRAWFQVEDDGPGIPP 375

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176173637 421 NELERVFDKFYR---ATETVevqeekGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:PRK09467  376 EQLKHLFQPFTRgdsARGSS------GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433

PRK10604

sensor protein RstB; Provisional

266-481

1.90e-16

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 81.19 E-value: 1.90e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 266 VSHELRSPLTSITgfSELLLDENISSDQSREysniILKESRRLSELINKYLDISRIESGKSEVHMTPLTMDDVIQSVVSM 345
Cdd:PRK10604  219 IAHELRTPLVRLR--YRLEMSDNLSAAESQA----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLAD 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 346 NAFLASSKNIQVKLrfPEKISSINADRQMMGEVILNLFSNAVKYspADTTVTISIEETGNEQIISVTDQGYGISENELER 425
Cdd:PRK10604  293 IQAVTPEKTVRLDT--PHQGDYGALDMRLMERVLDNLLNNALRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERER 368

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637 426 VFDKFYRATETVEvQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:PRK10604  369 VFEPFVRLDPSRD-RATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423

PRK10549

two-component system sensor histidine kinase BaeS;

266-463

2.53e-16

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 81.22 E-value: 2.53e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 266 VSHELRSPLTSITGFSELLLD-------ENISSDQSreysniilkESRRLSELINKYLDISRIESGKSEVHMTPLTMDDV 338
Cdd:PRK10549  247 ISHELRTPLAVLRGELEAIQDgvrkftpESVASLQA---------EVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 339 IQsvVSMNAF--LASSKNIQVKLRFPEKISSInADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGY 416
Cdd:PRK10549  318 LE--VAGGAFreRFASRGLTLQLSLPDSATVF-GDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAP 394

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1176173637 417 GISENELERVFDKFYRAtETVEVQEEKGTGLGLALVREIITKHHGRV 463
Cdd:PRK10549  395 GVSDEQLQKLFERFYRT-EGSRNRASGGSGLGLAICLNIVEAHNGRI 440

PRK10841

two-component system sensor histidine kinase RcsC;

259-483

2.63e-16

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 81.94 E-value: 2.63e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 259 KSEVVSMVSHELRSPLTSITGFSELLLDENISSDQSR------EYSNIILKesrrlseLINKYLDISRIESGKSEVHMTP 332
Cdd:PRK10841  447 KSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDRlvtamnNSSSLLLK-------IISDILDFSKIESEQLKIEPRE 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 333 LTMDDVIQSVVSmnAFLAssknIQVKLRF-------PEKISSINADRQMMGEVILNLFSNAVKYSpaDT-TVTISIEETG 404
Cdd:PRK10841  520 FSPREVINHITA--NYLP----LVVKKRLglycfiePDVPVALNGDPMRLQQVISNLLSNAIKFT--DTgCIVLHVRVDG 591

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173637 405 NEQIISVTDQGYGISENELERVFDKFYRATETVEvQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQ 483
Cdd:PRK10841  592 DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQ-RNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPLYG 669

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

371-463

3.71e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 74.04 E-value: 3.71e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 371 DRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRaTETVEVQEEKGTGLGLA 450
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYR-VESSRNRASGGSGLGLA 79

                          90
                  ....*....|...
gi 1176173637 451 LVREIITKHHGRV 463
Cdd:cd16946    80 ICHNIALAHGGTI 92

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

356-479

3.30e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.16 E-value: 3.30e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 356 QVKLRFPEKISSINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRAtE 435
Cdd:cd16947     2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTL-E 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1176173637 436 TVEVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIAL 479
Cdd:cd16947    81 DSRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

379-463

4.04e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.34 E-value: 4.04e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 379 ILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVEVQeeKGTGLGLALVREIITK 458
Cdd:cd16945     9 INNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ--KSTGLGLAFVQEVAQL 86


                  ....*
gi 1176173637 459 HHGRV 463
Cdd:cd16945    87 HGGRI 91

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-480

1.21e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 69.72 E-value: 1.21e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETvevQEEKGTGLGLALVRE 454
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS---RNTEGAGLGLSIAKA 77

                          90       100
                  ....*....|....*....|....*.
gi 1176173637 455 IITKHHGRVWVTSkLKQGSTFFIALP 480
Cdd:cd16923    78 IIELHGGSASAEY-DDNHDLFKVRLP 102

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-480

5.64e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 67.84 E-value: 5.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYspADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVEVQEeKGTGLGLALVRE 454
Cdd:cd16939     1 MARALDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRAT-GGFGLGLAIVHR 77

                          90       100
                  ....*....|....*....|....*.
gi 1176173637 455 IITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16939    78 VALWHGGHVECDDSELGGACFRLTWP 103

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-461

3.31e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 65.67 E-value: 3.31e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYSPADTT-VTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVEVQEEKgTGLGLALVR 453
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQH-SGLGLSISR 79


                  ....*...
gi 1176173637 454 EIITKHHG 461
Cdd:cd16953    80 QIIEAHGG 87

PRK10755

two-component system sensor histidine kinase PmrB;

266-462

1.19e-12

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 69.23 E-value: 1.19e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 266 VSHELRSPLTSITGFSELLLDENISSDQSreysniILKESRRLSELINKYLDISRIESGKSEVHMTPLTM-DDVIQSVVS 344
Cdd:PRK10755  144 VAHELRTPLAGIRLHLELLEKQHHIDVAP------LIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLlEDVILPSQD 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 345 -MNAFLASSkniQVKLRFPEKissiNADRQMMGEVIL------NLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYG 417
Cdd:PRK10755  218 eLSEMLEQR---QQTLLLPES----AADITVQGDATLlrlllrNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPG 290

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1176173637 418 ISENELERVFDKFYRATetvevQEEKGTGLGLALVREIITKHHGR 462
Cdd:PRK10755  291 IDESKCGELSKAFVRMD-----SRYGGIGLGLSIVSRITQLHHGQ 330

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

378-480

2.49e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.08 E-value: 2.49e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 378 VILNLFSNAVKYS----PADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYratetvEVQEEKGTGLGLALVR 453
Cdd:cd16915     4 IVGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV------STKGQGERGIGLALVR 77

                          90       100
                  ....*....|....*....|....*..
gi 1176173637 454 EIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16915    78 QSVERLGGSITVESEPGGGTTFSIRIP 104

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-463

5.51e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 62.08 E-value: 5.51e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKYspADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVEVqeeKGTGLGLALVRE 454
Cdd:cd16950     1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT---SGTGLGLAIVQR 75


                  ....*....
gi 1176173637 455 IITKHHGRV 463
Cdd:cd16950    76 ISDAHGGSL 84

glnL

PRK11073

nitrogen regulation protein NR(II);

143-481

1.29e-11

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 65.87 E-value: 1.29e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 143 ILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKglIEKVKSGTNSSEEKVEIEVTPENQRQP 222
Cdd:PRK11073   12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLN--IELMRESLQAGQGFTDNEVTLVIDGRS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 223 IILQAIATKvISDNRklfgVVIALRDLTREKEIDRKKS---------EVVSMVSHELRSPLTSITGFSELLldENISSDQ 293
Cdd:PRK11073   90 HILSLTAQR-LPEGM----ILLEMAPMDNQRRLSQEQLqhaqqvaarDLVRGLAHEIKNPLGGLRGAAQLL--SKALPDP 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 294 S-REYSNIILKESRRLSELINKYLDISRieSGKSEVHMTPLTMDDVIQsVVSMNaflaSSKNIQVKLRFPEKISSINADR 372
Cdd:PRK11073  163 AlTEYTKVIIEQADRLRNLVDRLLGPQR--PGTHVTESIHKVAERVVQ-LVSLE----LPDNVRLIRDYDPSLPELAHDP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 373 QMMGEVILNLFSNAVKySPADTTVTISIEETGNEQI------------ISVTDQGYGISENELERVFDKFYRAtetvevq 440
Cdd:PRK11073  236 DQIEQVLLNIVRNALQ-ALGPEGGTITLRTRTAFQLtlhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSG------- 307

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1176173637 441 EEKGTGLGLALVREIITKHHGRVWVTSklKQGST-FFIALPI 481
Cdd:PRK11073  308 REGGTGLGLSIARNLIDQHSGKIEFTS--WPGHTeFSVYLPI 347

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

377-479

1.31e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 60.93 E-value: 1.31e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 377 EVILNLFSNAVK--YSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYratETVEVQeeKGTGLGLALVRE 454
Cdd:cd16976     3 QVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVG--KGTGLGLSISYG 77

                          90       100
                  ....*....|....*....|....*
gi 1176173637 455 IITKHHGRVWVTSKLKQGSTFFIAL 479
Cdd:cd16976    78 IVEEHGGRLSVANEEGAGARFTFDL 102

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

352-479

1.39e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 61.88 E-value: 1.39e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 352 SKNIQVKLRFPEKISsINADRQMMGEVILNLFSNAVKYspADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFY 431
Cdd:cd16954    16 RKGVSISLDISPELR-FPGERNDLMELLGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQ 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1176173637 432 RATETVEvqeekGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIAL 479
Cdd:cd16954    93 RLDEQRP-----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

371-473

4.04e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.78 E-value: 4.04e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 371 DRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETveVQEEKGTGLGLA 450
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTS--RRSGGHYGMGLY 78

                          90       100
                  ....*....|....*....|...
gi 1176173637 451 LVREIITKHHGRVWVTSKLKQGS 473
Cdd:cd16975    79 IAKNLVEKHGGSLIIENSQKGGA 101

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

266-472

5.40e-11

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 65.09 E-value: 5.40e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 266 VSHELRSPLT--SITGFSELLLDENISSDQSREYSNIILKESRRLSELINKYLDISRiesgKSEVHMTPLTMDDVIQSvv 343
Cdd:COG4192   440 LAHELNQPLNamSMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR----KSDTPLQPVDLRQVIEQ-- 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 344 SMNAFLASSKNIQVKLRFPEKISsINADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGIseNEL 423
Cdd:COG4192   514 AWELVESRAKPQQITLHIPDDLM-VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW--PLV 590

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1176173637 424 ERVFDKFyraTETVEVqeekGTGLGLALVREIITKHHGRVWVTSKLKQG 472
Cdd:COG4192   591 DKLFTPF---TTTKEV----GLGLGLSICRSIMQQFGGDLYLASTLERG 632

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

378-480

9.21e-11

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 58.93 E-value: 9.21e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 378 VILNLFSNAVKYSPADTTVTISIEE---------------TGNEQIISVTDQGYGISENELERVFDKFYRATEtvevqEE 442
Cdd:cd16919     4 AILNLAVNARDAMPEGGRLTIETSNqrvdadyalnyrdliPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE-----VG 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1176173637 443 KGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16919    79 KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

138-286

3.08e-10

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 62.10 E-value: 3.08e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEkvksgtnSSEEKVEIEVTPE 217
Cdd:COG3829    11 EELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLK-------TGKPVTGVIQKTG 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176173637 218 NQRQPIILQAIatkVISDNRKLFGVVIALRDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLD 286
Cdd:COG3829    84 GKGKTVIVTAI---PIFEDGEVIGAVETFRDITELKRLERKLREEELERGLSAKYTFDDIIGKSPAMKE 149

PRK10815

two-component system sensor histidine kinase PhoQ;

237-467

7.29e-10

two-component system sensor histidine kinase PhoQ;

Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 61.19 E-value: 7.29e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 237 RKLFGVVIAL-RDLTREKEIDRKKSEVVSMVSHELRSPLTSI-TGFSELLLDENISSDQSREysnIILKESRRLSELINK 314
Cdd:PRK10815  243 RELTSLVRNLnRLLKNERERYTKYRTTLTDLTHSLKTPLAVLqSTLRSLRSGKQMSVEQAEP---IMLEQISRISQQIGY 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 315 YLDISRIESGKS----EVHMTPLTMDDVIqsvVSMNAfLASSKNIQVKLRFPEKISSINADRQMMgEVILNLFSNAVKYS 390
Cdd:PRK10815  320 YLHRASMRSEHNllsrELHSVAPLLDNLT---SALNK-VYQRKGVNITLDISPEITFVGEKNDFM-EVMGNVLDNACKYC 394

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637 391 PAdtTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRAtETVevqeEKGTGLGLALVREIITKHHGRVWVTS 467
Cdd:PRK10815  395 LE--FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRA-DTL----RPGQGLGLSVAREITEQYEGKISAGD 464

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

371-480

2.43e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 54.85 E-value: 2.43e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 371 DRQMMGEVILNLFSNA---VKYSPADT-TVTISIEETGNEQI-ISVTDQGYGISENELERvfdkfyrATETVEVQEEKGT 445
Cdd:cd16944     1 DTTQISQVLTNILKNAaeaIEGRPSDVgEVRIRVEADQDGRIvLIVCDNGKGFPREMRHR-------ATEPYVTTRPKGT 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1176173637 446 GLGLALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16944    74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108

PRK11086

sensory histidine kinase DcuS; Provisional

369-488

3.70e-09

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.77 E-value: 3.70e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 369 NADRQMMGE---VILNLFSN---AVKYSPaDTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRAtetvevqee 442
Cdd:PRK11086  425 SGDEDQVHElitILGNLIENaleAVGGEE-GGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYST--------- 494

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1176173637 443 KGT--GLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQREDIL 488
Cdd:PRK11086  495 KGSnrGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

354-481

5.29e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.11 E-value: 5.29e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 354 NIQvKLRFPEKIS-SINADRQMMGEVILNLFS-----NAVKY----SPADTTVTISIEETGNEQIISVTDQGYGISENEL 423
Cdd:COG2972   311 EIQ-KLRFGDRLEvEIEIDEELLDLLIPKLILqplveNAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKL 389

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176173637 424 ERVFDKFyratetveVQEEKGTGLGLALVREIITKHHG---RVWVTSKLKQGSTFFIALPI 481
Cdd:COG2972   390 EKLLEEL--------SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPL 442

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

375-480

3.89e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 51.25 E-value: 3.89e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 375 MGEVILNLFSNAVKySPADTTVTISIEETGNEQI------------ISVTDQGYGISENELERVFDKFYRAtetvevqEE 442
Cdd:cd16918     1 LIQVFLNLVRNAAQ-ALAGSGGEIILRTRTQRQVtlghprhrlalrVSVIDNGPGIPPDLQDTIFYPMVSG-------RE 72

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1176173637 443 KGTGLGLALVREIITKHHGRVWVTSklKQGSTFF-IALP 480
Cdd:cd16918    73 NGTGLGLAIAQNIVSQHGGVIECDS--QPGHTVFsVSLP 109

PRK13557

histidine kinase; Provisional

377-481

8.02e-08

histidine kinase; Provisional

Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 54.68 E-value: 8.02e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 377 EV-ILNLFSNAVKYSPADTTVTIsieETGNEQI------------------ISVTDQGYGISENELERVFDKFYRATEtv 437
Cdd:PRK13557  279 EVaLLNVLINARDAMPEGGRVTI---RTRNVEIededlamyhglppgryvsIAVTDTGSGMPPEILARVMDPFFTTKE-- 353

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1176173637 438 evqEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPI 481
Cdd:PRK13557  354 ---EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

349-484

4.49e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.16 E-value: 4.49e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 349 LASSKNIQVKLRFPEKISSINAdrqmmgEVILNLF-------SNAVKYSPAdTTVTISIEETGNEQIISVTDQGYGIsen 421
Cdd:COG4585   136 LLRAAGIRVELDVDGDPDRLPP------EVELALYrivqealTNALKHAGA-TRVTVTLEVDDGELTLTVRDDGVGF--- 205

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176173637 422 elervfdkfyratetvEVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQR 484
Cdd:COG4585   206 ----------------DPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252

COG3920

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...

329-486

3.28e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];

Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.52 E-value: 3.28e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 329 HMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEkiSSINADR-QMMGeVILN-LFSNAVKYSPADT---TVTISIEET 403
Cdd:COG3920   355 DWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD--VELPADAaVPLG-LILNeLVTNALKHAFLSGeggRIRVSWRRE 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 404 GNEQIISVTDQGYGISENelervfdkfyratetveVQEEKGTGLGLALVREIITKHHGRvwVTSKLKQGSTFFIALPIMQ 483
Cdd:COG3920   432 DGRLRLTVSDNGVGLPED-----------------VDPPARKGLGLRLIRALVRQLGGT--LELDRPEGTRVRITFPLAE 492


                  ...
gi 1176173637 484 RED 486
Cdd:COG3920   493 LAA 495

HATPase_UhpB-NarQ-NarX-like

cd16917

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

384-480

2.24e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.

Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 42.93 E-value: 2.24e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 384 SNAVKYSPAdTTVTISIEETGNEQIISVTDQGYGIsenelervfdkfyratetVEVQEEKGTGLGLALVREIITKHHGRV 463
Cdd:cd16917    10 TNALKHAGA-SRVRVTLSYTADELTLTVVDDGVGF------------------DGPAPPGGGGFGLLGMRERAELLGGTL 70

                          90
                  ....*....|....*..
gi 1176173637 464 WVTSKLKQGSTFFIALP 480
Cdd:cd16917    71 TIGSRPGGGTRVTARLP 87

dpiB

PRK15053

sensor histidine kinase DpiB; Provisional

360-486

5.44e-05

sensor histidine kinase DpiB; Provisional

Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 45.59 E-value: 5.44e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 360 RFPEKISSiNADRQMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYrATETVEV 439
Cdd:PRK15053  423 QLPPGLDS-TEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV-STRADEP 500

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1176173637 440 QEEkgtGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPIMQRED 486
Cdd:PRK15053  501 GEH---GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPND 544

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

391-480

5.45e-05

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 43.72 E-value: 5.45e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 391 PADTTVTISIEETGNEQIISVTDQGYGIS-ENELERVFDKFYRATETV---------------------EVQEEKGTGLG 448
Cdd:cd16916    67 PPEGTITLRAEHQGNQVVIEVSDDGRGIDrEKIREKAIERGLITADEAatlsddevlnlifapgfstaeQVTDVSGRGVG 146

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1176173637 449 LALVREIITKHHGRVWVTSKLKQGSTFFIALP 480
Cdd:cd16916   147 MDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178

PRK13560

hypothetical protein; Provisional

333-481

7.06e-05

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 45.43 E-value: 7.06e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 333 LTMDDVIQSVVS--MNAFLASSKNIQVKLRFPEKISSINadrQMM--GEVILNLFSNAVKYSPADTT---VTISIEETGN 405
Cdd:PRK13560  669 IDFLDYIESLTAhlKNSFAIDFGRIDCKIDADDGCLDID---KAIpcGLIISELLSNALKHAFPDGAagnIKVEIREQGD 745

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637 406 EQI-ISVTDQGYGISENelervFDkfYRATETvevqeekgtgLGLALVREIITKHHGRVWVTSklKQGSTFFIALPI 481
Cdd:PRK13560  746 GMVnLCVADDGIGLPAG-----FD--FRAAET----------LGLQLVCALVKQLDGEIALDS--RGGARFNIRFPM 803

RsbW

COG2172

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

368-455

7.54e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.21 E-value: 7.54e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 368 INADRQMMGEVILN-LFSNAVKYS---PADTTVTISIEETGNEQIISVTDQGYGISENELERVFDkfyratetvevqEEK 443
Cdd:COG2172    27 LDEDDADDLVLAVSeAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS------------TLA 94

                          90
                  ....*....|..
gi 1176173637 444 GTGLGLALVREI 455
Cdd:COG2172    95 EGGRGLFLIRRL 106

HAMP

cd06225

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...

81-116

4.20e-04

Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.81 E-value: 4.20e-04

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1176173637  81 IRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN 116
Cdd:cd06225     4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFN 39

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

138-204

4.93e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 38.53 E-value: 4.93e-04

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637  138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGTN 204
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67

PAS

COG2202

PAS domain [Signal transduction mechanisms];

138-258

5.26e-04

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 41.93 E-value: 5.26e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGTNSSEEKVEIEVTPE 217
Cdd:COG2202   137 ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLK 216

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1176173637 218 NQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRK 258
Cdd:COG2202   217 DGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEA 257

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

138-248

7.30e-04

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 39.32 E-value: 7.30e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 138 EKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIR---DDKLKGLIEKVKSGTNSSEEkVEIEV 214
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPeedDAEVAELLRQALLQGEESRG-FEVSF 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1176173637 215 TPENQRqPIILQAIATKVISDNRKLFGVVIALRD 248
Cdd:pfam00989  80 RVPDGR-PRHVEVRASPVRDAGGEILGFLGVLRD 112

PAS

cd00130

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

147-249

7.56e-04

Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 39.15 E-value: 7.56e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 147 IGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSG-TNSSEEKVEIEVTPENqRQPIIL 225
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLlSGGEPVTLEVRLRRKD-GSVIWV 79

                          90       100
                  ....*....|....*....|....
gi 1176173637 226 QAIATKVISDNRKLFGVVIALRDL 249
Cdd:cd00130    80 LVSLTPIRDEGGEVIGLLGVVRDI 103

PRK10618

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

267-486

1.66e-03

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 41.07 E-value: 1.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 267 SHELRSPLTSITGFSELLLDENISSDQSREySNIILKESRRLSELINKYLDISRIESGKSEVHMTPLTMDDVIQSVV--- 343
Cdd:PRK10618  458 GDELKQPLQSLAQLAAQLRQTSDEEQQQPE-LDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLpev 536

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 344 --SMNAflassKNIQVKLRFpekisSINADRQMMG--EVILNLFSNAVKYSPADT-----TVTISIEETGNEQI-ISVTD 413
Cdd:PRK10618  537 lpAIKR-----KGLQLLIHN-----HLKAEQLRIGdrDALRKILLLLLNYAITTTaygkiTLEVDQDESSPDRLtIRILD 606

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176173637 414 QGYGISENELERVfdKFYRATETVEVQEEKGTGLGLALVREIITKHHGRVWVTSKLKQGSTFFIALPiMQRED 486
Cdd:PRK10618  607 TGAGVSIKELDNL--HFPFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK-MLAAD 676

HATPase_MutL-MLH-PMS-like

cd16926

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...

376-431

2.06e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.

Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 39.34 E-value: 2.06e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637 376 GEVILNLFS-------NAVkyspaD---TTVTISIEETGNEQIIsVTDQGYGISENELERVFDKFY 431
Cdd:cd16926     8 GEVIERPASvvkelveNSI-----DagaTRIDVEIEEGGLKLIR-VTDNGSGISREDLELAFERHA 67

NarQ

COG3850

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...

51-116

2.49e-03

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];

Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 40.25 E-value: 2.49e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176173637  51 NFWFFIIILAISLSLSALTTRVLCSSFYERIRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN 116
Cdd:COG3850   116 NRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFN 181

HATPase_c_3

pfam13589

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...

394-467

2.60e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 433332 [Multi-domain] Cd Length: 135 Bit Score: 38.08 E-value: 2.60e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 394 TTVTISIE-ETGNEQIISVTDQGYGISENELERVF-----DKFYRATETveVQEEKGTGLGLALVR-----EIITKHHGR 462
Cdd:pfam13589  18 TNIKIEVNkNRGGGTEIVIEDDGHGMSPEELINALrlatsAKEAKRGST--DLGRYGIGLKLASLSlgaklTVTSKKEGK 95


                  ....*
gi 1176173637 463 VWVTS 467
Cdd:pfam13589  96 SSTLT 100

HAMP

COG2770

HAMP domain [Signal transduction mechanisms];

53-463

3.16e-03

HAMP domain [Signal transduction mechanisms];

Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 40.10 E-value: 3.16e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  53 WFFIIILAISLSLSALTTRVLCSSFYERIRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFNMLTKEHHEIKKKNVGE 132
Cdd:COG2770   212 LLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEE 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 133 KLFEWEKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIRDDKLKGLIEKVKSGTNSSEEKVEI 212
Cdd:COG2770   292 EELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEA 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 213 EVTPENQRQPIILQAIATKVISDNRKLFGVVIALRDLTREKEIDRKKSEVVSMVSHELRSPLTSITGFSELLLDENISSD 292
Cdd:COG2770   372 ELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAA 451

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 293 QSREYSNIILKESRRLSELINKYLDISRIESGKSEVHMTPLTMDDVIQSVVSMNAFLASSKNIQVKLRFPEKISSINADR 372
Cdd:COG2770   452 EAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEE 531

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637 373 QMMGEVILNLFSNAVKYSPADTTVTISIEETGNEQIISVTDQGYGISENELERVFDKFYRATETVEVQEEKGTGLGLALV 452
Cdd:COG2770   532 LLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALLLAAVAALLELAALLLLLLAAAEALAALELELAAAAEAAL 611

                         410
                  ....*....|.
gi 1176173637 453 REIITKHHGRV 463
Cdd:COG2770   612 AEAELLEVAAA 622

HAMP

smart00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

79-120

4.09e-03

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 35.30 E-value: 4.09e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1176173637   79 ERIRTYNQIARKIAGGQFELRIPVDAEDELGKFGKFFN-MLTK 120
Cdd:smart00304   5 RPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNeMADR 47

HATPase_YpdA-YehU-LytS-like

cd16924

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

382-454

4.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 36.66 E-value: 4.29e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176173637 382 LFSNAVKY--SPADTT--VTISIEETGNEQIISVTDQGYGISEnelervfdkfyRATETVEVQEEKGTGLGLALVRE 454
Cdd:cd16924     9 LVENAIQHglSPLTDKgvVTISALKEDNHVMIEVEDNGRGIDP-----------KVLNILGKKPKEGNGIGLYNVHQ 74

PRK09776

putative diguanylate cyclase; Provisional

128-260

5.85e-03

putative diguanylate cyclase; Provisional

Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 39.27 E-value: 5.85e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  128 KNVGEKLF-EWEKIQAILKNIGDGVVVIDNFNRIELMNSVAENWFNVTRQNYLSMELEKLIR-DDKLKG-LIEKVKSG-T 203
Cdd:PRK09776   525 RQLNEALFqEKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHiTFGDNGpLMENIYSClT 604

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176173637  204 NSSEEKVEIEVTPEN---QRQPIilQAIATKVISDNRKLFGVVIALRDLTREKEIDRKKS 260
Cdd:PRK09776   605 SRSAAYLEQDVVLHCrsgGSYDV--HYSITPLSTLDGENIGSVLVIQDVTESRKMLRQLS 662

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01