|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
81-313 |
2.69e-58 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 187.42 E-value: 2.69e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 81 WRRQLALNREQKNFIAQVTHELKSPVASIQLHLETIKRH-HPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRWR 159
Cdd:COG2205 6 LEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 160 LALRPHNLSQFLNDYLDQWGNS--QADDTILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRC 237
Cdd:COG2205 86 LELEPVDLAELLEEAVEELRPLaeEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176209583 238 NLLIRDKGRGIPLSEQHKVFRLFYRQHQeDSHIKGSGLGLFIARALIKRHKGKITLHSDGtQQGTTFHIVLPRIDE 313
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGDN-SRGEGGTGLGLAIVKRIVEAHGGTIWVESEP-GGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
3-313 |
7.76e-53 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 177.82 E-value: 7.76e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 3 LQRPNISPLVAFIAIQLTWIVVVVFWINWFLGSHRKLRNIAEKYSPELFHSEVDWIILVEGILLLIVILVGVYVIFIYWR 82
Cdd:COG5002 73 LLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 83 RQL----ALNREQKNFIAQVTHELKSPVASIQLHLETIKRH-HPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTR 157
Cdd:COG5002 153 RDIteleRLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 158 WRLALRPHNLSQFLNDYLDQWgNSQADD---TILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQ 234
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEEL-RPLAEEkgiELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREED 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 235 GRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSH-IKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLPRIDE 313
Cdd:COG5002 312 DQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSReTGGTGLGLAIVKHIVEAHGGRIWVESE-PGKGTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
11-310 |
2.20e-52 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 175.10 E-value: 2.20e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 11 LVAFIAIQLTWIVVVVFWINWFLGSHRKLRNIAEKYSPELFHSEVDWIILVEGILLLIVILVGVYVIFIYWRRQLALNRE 90
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 91 QKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQldSFVATMLTDTERLTSLINKLLTANRLEQTRWRLALRPHNLSQF 170
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR--EYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAEL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 171 LNDYLDQWgNSQADD---TILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRG 247
Cdd:COG0642 188 LEEVVELF-RPLAEEkgiELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPG 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176209583 248 IPLSEQHKVFRLFYRQHQEDSHiKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLPR 310
Cdd:COG0642 267 IPPEDLERIFEPFFRTDPSRRG-GGTGLGLAIVKRIVELHGGTIEVESE-PGKGTTFTVTLPL 327
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
86-315 |
3.42e-31 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 120.84 E-value: 3.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 86 ALNREQKN-----FIAQVTHELKSPVASIQLHLETIKRHHP-----ETQQLDSFVATMLTDTERLTSLINKLLTANRLEQ 155
Cdd:COG5000 191 ELLRAERLaawgeLARRIAHEIKNPLTPIQLSAERLRRKLAdkleeDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 156 TRwrlaLRPHNLSQFLNDYLD--QWGNSQADDTILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGE 233
Cdd:COG5000 271 PQ----LEPVDLNELLREVLAlyEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 234 QGRCNLLIRDKGRGIPLSEQHKVFRLFY--RQhqedshiKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLPRI 311
Cdd:COG5000 347 DGRVRIEVSDNGPGIPEEVLERIFEPFFttKP-------KGTGLGLAIVKKIVEEHGGTIELESR-PGGGTTFTIRLPLA 418
|
....
gi 1176209583 312 DESK 315
Cdd:COG5000 419 EEAE 422
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
88-313 |
2.64e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 116.81 E-value: 2.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 88 NREQKNFIAQVTHELKSPVASIQLHLETIKRHHPEtqQLDS----FVATMLTDTERLTSLINKLLTANRLEQTRwrLALR 163
Cdd:COG4251 279 NEELEQFAYVASHDLREPLRKISGFSQLLEEDYGD--KLDEegreYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFE 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 164 PHNLSQFLNDYLDQWGNSQADDTIlTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDP--PAQIWVELNGEQGRCNLLI 241
Cdd:COG4251 355 PVDLNELLEEVLEDLEPRIEERGA-EIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPgePPRIEIGAEREGGEWVFSV 433
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176209583 242 RDKGRGIPLSEQHKVFRLFYRQHQEDSHiKGSGLGLFIARALIKRHKGKITLHSDGTqQGTTFHIVLPRIDE 313
Cdd:COG4251 434 RDNGIGIDPEYAEKIFEIFQRLHSRDEY-EGTGIGLAIVKKIVERHGGRIWVESEPG-EGATFYFTLPKAPA 503
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
82-310 |
1.87e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 114.17 E-value: 1.87e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 82 RRQLalnrEQKNFIAQV----THELKSPVASIQLHLETIKRHHPEtQQLDSFVATMLTDTERLTSLINKLLTANRLEQTR 157
Cdd:PRK11100 247 RVKL----EGKAYVEQYvqtlTHELKSPLAAIRGAAELLQEDPPP-EDRARFTGNILTQSARLQQLIDRLLELARLEQRQ 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 158 WRLALRPHNLSQFLNDYLDQWGN--SQADDTILTRAIDNNVFAriEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQG 235
Cdd:PRK11100 322 ELEVLEPVALAALLEELVEAREAqaAAKGITLRLRPDDARVLG--DPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGE 399
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176209583 236 RCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSHIKGSGLGLFIARALIKRHKGKITLHsDGTQQGTTFHIVLPR 310
Cdd:PRK11100 400 QVALSVEDQGPGIPDYALPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLR-NRPEGGVLATLTLPR 473
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
202-309 |
2.25e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 105.81 E-value: 2.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 202 PDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSHIKGSGLGLFIAR 281
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIVK 82
|
90 100
....*....|....*....|....*...
gi 1176209583 282 ALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:smart00387 83 KLVELHGGEISVESE-PGGGTTFTITLP 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
205-308 |
2.43e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 99.98 E-value: 2.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRqHQEDSHIKGSGLGLFIARALI 284
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYR-GDKSREGGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|....
gi 1176209583 285 KRHKGKITLHSDGtQQGTTFHIVL 308
Cdd:cd00075 80 EAHGGRITVESEP-GGGTTFTVTL 102
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
98-310 |
2.21e-23 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 98.72 E-value: 2.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 98 VTHELKSPVASIQLHLETIKR---HHPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRwrlaLRPHNLSQFLNDY 174
Cdd:COG4191 149 IAHEINNPLAAILGNAELLRRrleDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 175 LDQWGNSQADDTI-LTRAIDNNVFA-RIEPDSLTMVLRNLLENAV--LYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPL 250
Cdd:COG4191 225 LELLRPRLKARGIeVELDLPPDLPPvLGDPGQLEQVLLNLLINAIdaMEEGEGGRITISTRREGDYVVISVRDNGPGIPP 304
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176209583 251 SEQHKVFRLFY--RQHQedshiKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLPR 310
Cdd:COG4191 305 EVLERIFEPFFttKPVG-----KGTGLGLSISYGIVEKHGGRIEVESE-PGGGTTFTITLPL 360
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
202-309 |
4.11e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 91.66 E-value: 4.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 202 PDSLTMVLRNLLENAVLYSDPPAQIWVELNgEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQhqEDSHIKGSGLGLFIAR 281
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTA--DKRGGGGTGLGLSIVR 79
|
90 100
....*....|....*....|....*...
gi 1176209583 282 ALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:pfam02518 80 KLVELLGGTITVESE-PGGGTTVTLTLP 106
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
84-316 |
7.67e-22 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 94.14 E-value: 7.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 84 QLALNREqknFIAQVTHELKSPVASIQLHLETIKRHHPEtQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRwrlaLR 163
Cdd:COG3852 131 KLAAVGE---LAAGLAHEIRNPLTGIRGAAQLLERELPD-DELREYTQLIIEEADRLNNLVDRLLSFSRPRPPE----RE 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 164 PHNLSQFLNDYLDQWGNSQADDTILTRAIDNNV-FARIEPDSLTMVLRNLLENAVLYSDPPAQI--------WVELNGEQ 234
Cdd:COG3852 203 PVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTItirtrverQVTLGGLR 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 235 GRCNLLIR--DKGRGIPLSEQHKVFRLFYRqhqedSHIKGSGLGLFIARALIKRHKGKITLHSdGTQQGTTFHIVLPRID 312
Cdd:COG3852 283 PRLYVRIEviDNGPGIPEEILDRIFEPFFT-----TKEKGTGLGLAIVQKIVEQHGGTIEVES-EPGKGTTFRIYLPLEQ 356
|
....
gi 1176209583 313 ESKP 316
Cdd:COG3852 357 AEEE 360
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
43-316 |
1.77e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 90.41 E-value: 1.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 43 AEKYSPELFHSEVDWIILVEGILLLIVIlvgvyvifiywRRQLALNREqKNFIAQVTHELKSPVASIQLHLETI-KRHHP 121
Cdd:PRK10755 101 ADNLTPIAIHSSTLEIEAVTSALNQLVS-----------RLTSTLDQE-RLFTADVAHELRTPLAGIRLHLELLeKQHHI 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 122 ETQQLDSFVATMLTDTERL-----------------TSLINKLLTANRlEQTRWRLALRPHNLsqflndyldQWGNSQAD 184
Cdd:PRK10755 169 DVAPLIARLDQMMHTVEQLlqlaragqsfssghyqtVKLLEDVILPSQ-DELSEMLEQRQQTL---------LLPESAAD 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 185 DTILTRAIdnnvfariepdSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQh 264
Cdd:PRK10755 239 ITVQGDAT-----------LLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM- 306
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1176209583 265 qeDSHIKGSGLGLFIARALIKRHKGKITLHSDGTQQGTTFHIVLPRIDESKP 316
Cdd:PRK10755 307 --DSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWLPKAQNVAN 356
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
201-302 |
1.60e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 82.07 E-value: 1.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 201 EPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGrCNLLIRDKGRGIPLSEQHKVFRLFYRqhQEDSHIKGSGLGLFIA 280
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYR--SDGQNYGGSGLGLSIV 86
|
90 100
....*....|....*....|..
gi 1176209583 281 RALIKRHKGKITLhSDGTQQGT 302
Cdd:cd16940 87 KRIVELHGGQIFL-GNAQGGGL 107
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-309 |
4.69e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 80.83 E-value: 4.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYSDPPAQIWVEL----NGEQGRcnLLIRDKGRGIPLSEQHKVFRLFYRQH-QEDSHikGSGLGLFI 279
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVgaedVGEEWT--FYVRDNGIGIDPEYAEKVFGIFQRLHsREEYE--GTGVGLAI 76
|
90 100 110
....*....|....*....|....*....|
gi 1176209583 280 ARALIKRHKGKITLHSdGTQQGTTFHIVLP 309
Cdd:cd16921 77 VRKIIERHGGRIWLES-EPGEGTTFYFTLP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
85-309 |
3.18e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 85.09 E-value: 3.18e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 85 LALNREQ-KN-FIAQVTHELKSPV------ASIqLHLETIKRHHPETQQLDSFVATMLTDTErltsLINKLLTANRLEQT 156
Cdd:PRK10490 656 LASEREQlRNaLLAALSHDLRTPLtvlfgqAEI-LTLDLASEGSPHARQASEIRQQVLNTTR----LVNNLLDMARIQSG 730
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 157 RWRLALRPHNLSQFLNDYLDQWGNSQADDTILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGR 236
Cdd:PRK10490 731 GFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGER 810
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176209583 237 CNLLIRDKGRGIPLSEQHKVFRLFYRQHQEdSHIKGSGLGLFIARALIKRHKGKITLHSdGTQQGTTFHIVLP 309
Cdd:PRK10490 811 LQLDVWDNGPGIPPGQEQLIFDKFARGNKE-SAIPGVGLGLAICRAIVEVHGGTIWAEN-RPEGGACFRVTLP 881
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
91-309 |
2.04e-17 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 82.86 E-value: 2.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 91 QKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRWRLALRPHNLSQF 170
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 171 LNDYLDQWGNSQADDTI---LTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPA----QIWVELNGEQGRCNLLIRD 243
Cdd:PRK09959 792 VQNTCHSFGAIAASKSIalsCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvkitTSLGHIDDNHAVIKMTIMD 871
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176209583 244 KGRGIPLSEQHKVFRLfYRQHQEDSHIKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:PRK09959 872 SGSGLSQEEQQQLFKR-YSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESH-PGIGTTFTITIP 935
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
82-287 |
4.94e-17 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 81.23 E-value: 4.94e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 82 RRQLALNREQKnFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRWRLA 161
Cdd:PRK10337 229 RTHAMMVRERR-FTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQD 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 162 LRPHNLSQFLNDYL-DQWGNSQADDTILTRAIDN-NVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEqgrcNL 239
Cdd:PRK10337 308 VAEIPLEDLLQSAVmDIYHTAQQAGIDVRLTLNAhPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NF 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1176209583 240 LIRDKGRGIPLSEQHKVFRLFYR-QHQEDShikGSGLGLFIARALIKRH 287
Cdd:PRK10337 384 TVRDNGPGVTPEALARIGERFYRpPGQEAT---GSGLGLSIVRRIAKLH 429
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
209-309 |
8.17e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 71.97 E-value: 8.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 209 LRNLLENAVLYSdpPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQ-EDSHIKGSGLGLFIARALIKRH 287
Cdd:cd16949 5 LENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSaRDRESGGTGLGLAIAERAIEQH 82
|
90 100
....*....|....*....|..
gi 1176209583 288 KGKITLhSDGTQQGTTFHIVLP 309
Cdd:cd16949 83 GGKIKA-SNRKPGGLRVRIWLP 103
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
83-316 |
8.46e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 78.14 E-value: 8.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 83 RQLALNR-----EQKN-----FIAQVTHELKSPVASIQLHLETIKRHHPETQQLDsfvatmLTDTER-----LTSLINKL 147
Cdd:PRK15347 380 RTQALAEakqraEQANkrkseHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMD------LADTARqctlsLLAIINNL 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 148 LTANRLEQTRWRLALRPHNLSQFLNdyldqwgnsQADDTILTRAIDN----------NVFARIEPDSLTM--VLRNLLEN 215
Cdd:PRK15347 454 LDFSRIESGQMTLSLEETALLPLLD---------QAMLTIQGPAQSKsltlrtfvgaHVPLYLHLDSLRLrqILVNLLGN 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 216 AVLYSdPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYrqhQEDSHIKGSGLGLFIARALIKRHKGKITLHS 295
Cdd:PRK15347 525 AVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFY---QADTHSQGTGLGLTIASSLAKMMGGELTLFS 600
|
250 260
....*....|....*....|.
gi 1176209583 296 DgTQQGTTFHIVLPRIDESKP 316
Cdd:PRK15347 601 T-PGVGSCFSLVLPLNEYAPP 620
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
193-308 |
1.67e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 71.78 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 193 DNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVF-RLFYRQHQEDSHIK 271
Cdd:cd16947 9 DRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFeRLYTLEDSRNSAKQ 88
|
90 100 110
....*....|....*....|....*....|....*..
gi 1176209583 272 GSGLGLFIARALIKRHKGKITLHSDGTQQgTTFHIVL 308
Cdd:cd16947 89 GNGLGLTITKRLAESMGGSIYVNSKPYEK-TVFTVTL 124
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
86-295 |
1.92e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 76.18 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 86 ALNREQKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQldsfvaTMLTDTERLTSLINKLLTANRLEQTRWRLALRPH 165
Cdd:PRK10604 207 ALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQ------ALNRDIGQLEALIEELLTYARLDRPQNELHLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 166 NLSQFLNDYLDQWGNSQADDTILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGrcNLLIRDKG 245
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQA--CLIVEDDG 358
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1176209583 246 RGIPLSEQHKVFRLFYRQHQE-DSHIKGSGLGLFIARALIKRHKGKITLHS 295
Cdd:PRK10604 359 PGIPPEERERVFEPFVRLDPSrDRATGGCGLGLAIVHSIALAMGGSVNCDE 409
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
94-316 |
2.12e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 76.55 E-value: 2.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 94 FIAQVTHELKSPVASI----QLHLETIKRH-HPEtqqldsFVATMLTDTERLTSLINKLLTANRLEQTRWRlalrPHNLS 168
Cdd:PRK11360 393 LVAGVAHEIRNPLTAIrgyvQIWRQQTSDPpSQE------YLSVVLREVDRLNKVIDQLLEFSRPRESQWQ----PVSLN 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 169 QFLNDYLDQWGNSQADDTI-LTRAIDNNV-FARIEPDSLTMVLRNLLENAvlYSDPPAQIWVELNGEQ---GRCNLLIRD 243
Cdd:PRK11360 463 ALVEEVLQLFQTAGVQARVdFETELDNELpPIWADPELLKQVLLNILINA--VQAISARGKIRIRTWQysdGQVAVSIED 540
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1176209583 244 KGRGIPLSEQHKVFRLFYRQHQedshiKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLPRIDESKP 316
Cdd:PRK11360 541 NGCGIDPELLKKIFDPFFTTKA-----KGTGLGLALSQRIINAHGGDIEVESE-PGVGTTFTLYLPINPQGNQ 607
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
208-309 |
5.33e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 69.83 E-value: 5.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 208 VLRNLLENAVLYSDppaQ----IWVELNGEQGRCNLL---IRDKGRGIPLSEQHKVFRLFyrqHQEDSHIK----GSGLG 276
Cdd:cd16922 4 ILLNLLGNAIKFTE---EgevtLRVSLEEEEEDGVQLrfsVEDTGIGIPEEQQARLFEPF---SQADSSTTrkygGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 1176209583 277 LFIARALIKRHKGKITLHS-DGtqQGTTFHIVLP 309
Cdd:cd16922 78 LAISKKLVELMGGDISVESePG--QGSTFTFTLP 109
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
83-309 |
6.41e-15 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 74.66 E-value: 6.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 83 RQLALNReqKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVATMLTDTERLTSLINKLLTANRLEqtrwrlAL 162
Cdd:PRK11006 198 HQLEGAR--RNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIE------AA 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 163 RPHNLSQFLN-----DYLDQWGNSQADDT-ILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVE-LNGEQG 235
Cdd:PRK11006 270 PTIDLNEKVDvpmmlRVLEREAQTLSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRwQRVPQG 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176209583 236 RCnLLIRDKGRGIPLSEQHKVFRLFYRQHQEDS-HIKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:PRK11006 350 AE-FSVEDNGPGIAPEHIPRLTERFYRVDKARSrQTGGSGLGLAIVKHALSHHDSRLEIESE-VGKGTRFSFVLP 422
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
89-309 |
7.75e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 74.22 E-value: 7.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 89 REQKNF----IAQVTHELKSPVASIQLHLETIK--RHHPETQQLDSFVATMLTDTERLTSLINKLLTaNRLE--QTRW-R 159
Cdd:PRK09303 145 LEQLKFkdrvLAMLAHDLRTPLTAASLALETLElgQIDEDTELKPALIEQLQDQARRQLEEIERLIT-DLLEvgRTRWeA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 160 LALRPH-----NLSQ-FLNDYLDQWgnsQADDTILTRAIDN---NVFAriEPDSLTMVLRNLLENAVLYSDPPAQI---- 226
Cdd:PRK09303 224 LRFNPQkldlgSLCQeVILELEKRW---LAKSLEIQTDIPSdlpSVYA--DQERIRQVLLNLLDNAIKYTPEGGTItlsm 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 227 ------WVELNgeqgrcnllIRDKGRGIPLSEQHKVF----RLfyrqhQEDSHIKGSGLGLFIARALIKRHKGKITLHSD 296
Cdd:PRK09303 299 lhrttqKVQVS---------ICDTGPGIPEEEQERIFedrvRL-----PRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSE 364
|
250
....*....|...
gi 1176209583 297 gTQQGTTFHIVLP 309
Cdd:PRK09303 365 -PGQGSCFHFTLP 376
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
94-309 |
2.77e-14 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 73.09 E-value: 2.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 94 FIAQVTHELKSPVAS----IQLHLETIKRHHpetqqlDSFVATMLTDTERLTSLINKLL-----TANRLEQTrwrlalrp 164
Cdd:COG5809 273 LAAGIAHEIRNPLTSlkgfIQLLKDTIDEEQ------KTYLDIMLSELDRIESIISEFLvlakpQAIKYEPK-------- 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 165 hNLSQFLNDYLDqwgnsqaddTILTRAIDNNVFARIEPDS-----------LTMVLRNLLENAVLYSDPPAQIWVELNG- 232
Cdd:COG5809 339 -DLNTLIEEVIP---------LLQPQALLKNVQIELELEDdipdilgdenqLKQVFINLLKNAIEAMPEGGNITIETKAe 408
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176209583 233 EQGRCNLLIRDKGRGIPLSEQHKVFRLFY-RQHqedshiKGSGLGLFIARALIKRHKGKITLHSDGtQQGTTFHIVLP 309
Cdd:COG5809 409 DDDKVVISVTDEGCGIPEERLKKLGEPFYtTKE------KGTGLGLMVSYKIIEEHGGKITVESEV-GKGTTFSITLP 479
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
208-309 |
5.28e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 67.03 E-value: 5.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 208 VLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQhQEDSHIKGSGLGLFIARALIKRH 287
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRG-DNSRNTEGAGLGLSIAKAIIELH 82
|
90 100
....*....|....*....|..
gi 1176209583 288 KGKITLHSDGtqQGTTFHIVLP 309
Cdd:cd16923 83 GGSASAEYDD--NHDLFKVRLP 102
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
59-315 |
9.93e-14 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 71.36 E-value: 9.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 59 ILVEGILLLIVILVGVYVIFIYWR----RQL---ALNREQK-----NFIAQVTHELKSPVASIQLHLETIKRHHPETQQL 126
Cdd:PRK10364 193 TLIILFALATVLLASLLAFFWYRRylrsRQLlqdEMKRKEKlvalgHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEA 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 127 DSFVATMLTDTERLTSLINKLLtanrlEQTR-WRLALRPHNLSQFLNDYL---DQWGNSQADDTILTRAiDNNVFARIEP 202
Cdd:PRK10364 273 HQLAQVMAKEADRLNRVVSELL-----ELVKpTHLALQAVDLNDLINHSLqlvSQDANSREIQLRFTAN-DTLPEIQADP 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 203 DSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEdshikGSGLGLFIARA 282
Cdd:PRK10364 347 DRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE-----GTGLGLAVVHN 421
|
250 260 270
....*....|....*....|....*....|...
gi 1176209583 283 LIKRHKGKITLHSDgTQQGTTFHIVLPRIDESK 315
Cdd:PRK10364 422 IVEQHGGTIQVASQ-EGKGATFTLWLPVNITRR 453
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
198-310 |
1.11e-13 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 71.03 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 198 ARIEPDSLTMVLRNLLENAV----LYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRL-FYRQHQEdshikG 272
Cdd:COG3290 275 LPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgFSTKLGE-----G 349
|
90 100 110
....*....|....*....|....*....|....*...
gi 1176209583 273 SGLGLFIARALIKRHKGKITLHSDGtQQGTTFHIVLPR 310
Cdd:COG3290 350 RGLGLALVKQIVEKYGGTIEVESEE-GEGTVFTVRLPK 386
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
84-309 |
1.46e-13 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 70.82 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 84 QLALNREqKN------FIAQVTHELKSPVASIQLHLETI----KRHHPETqqldsfVATMLTDTERLTSLINKLltaNRL 153
Cdd:PRK10549 228 QLASTLE-KNeqmrrdFMADISHELRTPLAVLRGELEAIqdgvRKFTPES------VASLQAEVGTLTKLVDDL---HQL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 154 EQT-RWRLALR--PHNLSQFLN----DYLDQWGNSQAddTILTRAIDNN-VFAriEPDSLTMVLRNLLENAVLYSDPPAQ 225
Cdd:PRK10549 298 SLSdEGALAYRktPVDLVPLLEvaggAFRERFASRGL--TLQLSLPDSAtVFG--DPDRLMQLFNNLLENSLRYTDSGGS 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 226 IWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRqhQEDSHIK---GSGLGLFIARALIKRHKGKITL-HSD-Gtqq 300
Cdd:PRK10549 374 LHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYR--TEGSRNRasgGSGLGLAICLNIVEAHNGRIIAaHSPfG--- 448
|
....*....
gi 1176209583 301 GTTFHIVLP 309
Cdd:PRK10549 449 GVSITVELP 457
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
202-310 |
1.91e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 65.52 E-value: 1.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 202 PDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDshiKGSGLGLFIAR 281
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVG---EGTGLGLSLSY 77
|
90 100
....*....|....*....|....*....
gi 1176209583 282 ALIKRHKGKITLHSDgTQQGTTFHIVLPR 310
Cdd:cd16943 78 RIIQKHGGTIRVASV-PGGGTRFTIILPI 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
91-310 |
3.00e-13 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 69.80 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 91 QKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVATMLTDTERLTSLINKLL-----TANRLEQTRWRLALRPH 165
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLflaqaDNNQLIPEKKMLDLADE 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 166 NLSQFlnDYLDQWGNSQAddtILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKG 245
Cdd:PRK09835 342 VGKVF--DFFEAWAEERG---VELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPG 416
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176209583 246 RGIPLSEQHKVFRLFYR---QHQEDShiKGSGLGLFIARALIKRHKGKITLHSDGtqQGTTFHIVLPR 310
Cdd:PRK09835 417 TPIAPEHLPRLFDRFYRvdpSRQRKG--EGSGIGLAIVKSIVVAHKGTVAVTSDA--RGTRFVISLPR 480
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
89-316 |
6.52e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 69.20 E-value: 6.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 89 REQKNFIAQVTHELKSPVASIqLHLETIKRHHPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRWRLALRPHNLS 168
Cdd:PRK11091 281 RDKTTFISTISHELRTPLNGI-VGLSRILLDTELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFT 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 169 QFLNDyLDQWGNSQADDTIL--TRAIDNNVFARIEPDS--LTMVLRNLLENAVLYSdPPAQIWVELNGEQGRCNLL-IRD 243
Cdd:PRK11091 360 DFLAD-LENLSGLQAEQKGLrfDLEPLLPLPHKVITDGtrLRQILWNLISNAVKFT-QQGGVTVRVRYEEGDMLTFeVED 437
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176209583 244 KGRGIPLSEQHKVFRLFY--RQHQEDSHIKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTF--HIVLPRIDESKP 316
Cdd:PRK11091 438 SGIGIPEDELDKIFAMYYqvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSE-EGKGSCFtlTIHAPAVAEEVE 513
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
86-291 |
1.14e-12 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 68.04 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 86 ALNR---EQKNFIAQVTHELKSPVASIQLHLETIKRHH---PETQQLDsfvatmlTDTERLTSLINKLLTANRlEQTRWR 159
Cdd:PRK09470 235 ALERmmtSQQRLLSDISHELRTPLTRLQLATALLRRRQgesKELERIE-------TEAQRLDSMINDLLVLSR-NQQKNH 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 160 LALRPHNLSQFLNDYLD--QWGNSQADDTILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDppAQIWVELNGEQGRC 237
Cdd:PRK09470 307 LERETFKANSLWSEVLEdaKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGL 384
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1176209583 238 NLLIRDKGRGIPLSEQHKVFRLFYR-QHQEDSHIKGSGLGLFIARALIKRHKGKI 291
Cdd:PRK09470 385 TITVDDDGPGVPEEEREQIFRPFYRvDEARDRESGGTGLGLAIVENAIQQHRGWV 439
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
201-293 |
1.86e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.86 E-value: 1.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 201 EPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSHIKGSGLGLFIA 280
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90
....*....|...
gi 1176209583 281 RALIKRHKGKITL 293
Cdd:cd16945 81 QEVAQLHGGRITL 93
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-309 |
6.09e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 61.43 E-value: 6.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYSDPP-AQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSHI-KGSGLGLFIARA 282
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFgQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 1176209583 283 LIKRHKGKIT--LHSDGTQ-QGTTFHIVLP 309
Cdd:cd16953 81 IIEAHGGISVaeNHNQPGQvIGARFTVQLP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
208-293 |
6.90e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 58.23 E-value: 6.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 208 VLRNLLENAVLYsdppAQIWVELN--GEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDShIKGSGLGLFIARALIK 285
Cdd:cd16950 4 VLSNLVDNALRY----GGGWVEVSsdGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG-TSGTGLGLAIVQRISD 78
|
....*...
gi 1176209583 286 RHKGKITL 293
Cdd:cd16950 79 AHGGSLTL 86
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
201-291 |
1.57e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 57.47 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 201 EPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRqhQEDSHIK---GSGLGL 277
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYR--VESSRNRasgGSGLGL 78
|
90
....*....|....
gi 1176209583 278 FIARALIKRHKGKI 291
Cdd:cd16946 79 AICHNIALAHGGTI 92
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
188-308 |
1.60e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 58.03 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 188 LTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPpaqiWVELNGEQ--GRCNLLIRDKGRGIPLSEQHKVFRlfyRQHQ 265
Cdd:cd16954 21 ISLDISPELRFPGERNDLMELLGNLLDNACKWCLE----FVEVTARQtdGGLHLIVDDDGPGVPESQRSKIFQ---RGQR 93
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1176209583 266 EDSHIKGSGLGLFIARALIKRHKGKITLhSDGTQQGTTFHIVL 308
Cdd:cd16954 94 LDEQRPGQGLGLAIAKEIVEQYGGELSL-SDSPLGGARFEVVF 135
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-309 |
1.91e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.91 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYS----DPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEdshiKGSGLGLFIA 280
Cdd:cd16915 1 LITIVGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ----GERGIGLALV 76
|
90 100
....*....|....*....|....*....
gi 1176209583 281 RALIKRHKGKITLhSDGTQQGTTFHIVLP 309
Cdd:cd16915 77 RQSVERLGGSITV-ESEPGGGTTFSIRIP 104
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
201-309 |
2.12e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 57.12 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 201 EPDSLTMVLRNLLENAVLYSDPPAQIWVELN-GEQGRCNLLIRDKGRGIPLSEQHKVFRLFyRQHQEDSHIK--GSGLGL 277
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERF-RQGDGSSTRAhgGTGLGL 79
|
90 100 110
....*....|....*....|....*....|..
gi 1176209583 278 FIARALIKRHKGKITLHsDGTQQGTTFHIVLP 309
Cdd:cd16925 80 SIVKEFVELHGGTVTVS-DAPGGGALFQVELP 110
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
88-152 |
2.61e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 55.30 E-value: 2.61e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176209583 88 NREQKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVATMLTDTERLTSLINKLLTANR 152
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-310 |
4.08e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 56.28 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYSDPPAQIWVELNGeqGRCNLLIRDKGRGIPLSEQHKVFRLFYR-QHQEDSHIKGSGLGLFIARAL 283
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSG--GRLTLIVEDDGPGIPAAARERVFEPFVRlDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*..
gi 1176209583 284 IKRHKGKITLhSDGTQQGTTFHIVLPR 310
Cdd:cd16939 79 ALWHGGHVEC-DDSELGGACFRLTWPR 104
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
97-295 |
1.33e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 58.93 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 97 QVTHELKSPVASIQLHLETIKRhhPETQQLDSFVATMLTDTERLTSLINKLLTANRLEQTRWRLALRPHNLSQFLNDYLD 176
Cdd:COG4192 439 SLAHELNQPLNAMSMYLFSAKK--ALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWE 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 177 QWgNSQA--DDTILTRAIDNNVFAriEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEqh 254
Cdd:COG4192 517 LV-ESRAkpQQITLHIPDDLMVQG--DQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD-- 591
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1176209583 255 KVFRLFYrqhqeDSHIKGSGLGLFIARALIKRHKGKITLHS 295
Cdd:COG4192 592 KLFTPFT-----TTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
90-155 |
1.50e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 53.37 E-value: 1.50e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176209583 90 EQKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDsFVATMLTDTERLTSLINKLLTANRLEQ 155
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE-YLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
58-310 |
4.19e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 56.17 E-value: 4.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 58 IILVEGILLLIVILVGVYVIFIYWRRQLALNR--------------EQKNFIAQ-----VTHELkspvASIQLHLETIKR 118
Cdd:COG4585 6 LLGALALLVGALLGLLLALVLLRARRAERAAElerelaaraeeareEERRRIARelhdgVGQSL----SAIKLQLEAARR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 119 hhpetqQLDSFVATMLTDTERLTSLINKLLTANRleqtRWRLALRPHNLSQF-----LNDYLDQWGNSQADDTILTRAID 193
Cdd:COG4585 82 ------LLDADPEAAREELEEIRELAREALAELR----RLVRGLRPPALDDLglaaaLEELAERLLRAAGIRVELDVDGD 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 194 NNVF-ARIEpDSLTMVLRNLLENAVLYSdPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEqhkvfrlfyrqhqedshIKG 272
Cdd:COG4585 152 PDRLpPEVE-LALYRIVQEALTNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDPEA-----------------APG 212
|
250 260 270
....*....|....*....|....*....|....*...
gi 1176209583 273 SGLGLFIARALIKRHKGKITLHSdGTQQGTTFHIVLPR 310
Cdd:COG4585 213 GGLGLRGMRERAEALGGTLTIGS-APGGGTRVRATLPL 249
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
188-308 |
4.64e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 57.55 E-value: 4.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 188 LTRAIDNNVfariePDSLT-------MVLRNLLENAVLYSDPPA-QIWVEL---NGEQGRCNLLIRDKGRGIPLSEQHKV 256
Cdd:PRK11107 390 LTLNIDPDV-----PDNVIgdplrlqQIITNLVGNAIKFTESGNiDILVELralSNTKVQLEVQIRDTGIGISERQQSQL 464
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1176209583 257 FRLFyrqHQEDSHIK----GSGLGLFIARALIKRHKGKITLHSDgTQQGTTF--HIVL 308
Cdd:PRK11107 465 FQAF---RQADASISrrhgGTGLGLVITQKLVNEMGGDISFHSQ-PNRGSTFwfHLPL 518
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
90-155 |
6.17e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 51.80 E-value: 6.17e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176209583 90 EQKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDsFVATMLTDTERLTSLINKLLTANRLEQ 155
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQRE-YLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
208-297 |
1.15e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 52.07 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 208 VLRNLLENAVL--YSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDshiKGSGLGLFIARALIK 285
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVG---KGTGLGLSISYGIVE 80
|
90
....*....|..
gi 1176209583 286 RHKGKITLHSDG 297
Cdd:cd16976 81 EHGGRLSVANEE 92
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
95-309 |
1.41e-08 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 55.69 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 95 IAQVTHELKSPVASIQLHLETIKrhhPEtqqlDSFVA-TMLTDTERLTSLINKLLTANRLEQtrwRLALRPHNLSQFLND 173
Cdd:PRK09467 233 MAGVSHDLRTPLTRIRLATEMMS---EE----DGYLAeSINKDIEECNAIIEQFIDYLRTGQ---EMPMEMADLNALLGE 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 174 YLDQWGNSQADdtILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDppAQIWVELNGEQGRCNLLIRDKGRGIPLSEQ 253
Cdd:PRK09467 303 VIAAESGYERE--IETALQPGPIEVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEGKRAWFQVEDDGPGIPPEQL 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1176209583 254 HKVFRLFYRQHQEDSHIkGSGLGLFIARALIKRHKGKITLhSDGTQQGTTFHIVLP 309
Cdd:PRK09467 379 KHLFQPFTRGDSARGSS-GTGLGLAIVKRIVDQHNGKVEL-GNSEEGGLSARAWLP 432
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
96-309 |
1.68e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 55.51 E-value: 1.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 96 AQVTHELKSPVASI----QLHLETIKRHHpetqqldSFVATMLTDTERLTSLINKLLTANRLEQTRwrlaLRPHNLSQFL 171
Cdd:COG5805 292 AGIAHEIRNPLTSIkgflQLLQPGIEDKE-------EYFDIMLSELDRIESIISEFLALAKPQAVN----KEKENINELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 172 NDyLDQWGNSQA---DDTILTRAIDNNVFARIEPDSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGI 248
Cdd:COG5805 361 QD-VVTLLETEAilhNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGI 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176209583 249 PLSEQHKVFRLFYRQHQedshiKGSGLGLFIARALIKRHKGKITLHSdGTQQGTTFHIVLP 309
Cdd:COG5805 440 PEERLKKLGEPFFTTKE-----KGTGLGLMVSYKIIENHNGTIDIDS-KVGKGTTFTITLP 494
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
211-309 |
5.12e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 50.28 E-value: 5.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 211 NLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSHIK-GSGLGLFIARALIKRHKG 289
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTgGTGLGLAIVKHVMSRHDA 86
|
90 100
....*....|....*....|
gi 1176209583 290 KITLHSDgTQQGTTFHIVLP 309
Cdd:cd16952 87 RLLIASE-LGKGSRFTCLFP 105
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
84-309 |
1.92e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 52.28 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 84 QLALNREQKN-----FIAQVTHELKSPVASIQLHLETIKRHH-PetQQLDSFVATMLTDTERLTSLINKLLTANRLEQTR 157
Cdd:PRK10841 435 EMAQAAEQASqsksmFLATVSHELRTPLYGIIGNLDLLQTKElP--KGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQ 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 158 WRLALRPHN----LSQFLNDYL-----DQWGnsqaddtiLTRAIDNNVFARIEPDS--LTMVLRNLLENAVLYSDPpAQI 226
Cdd:PRK10841 513 LKIEPREFSprevINHITANYLplvvkKRLG--------LYCFIEPDVPVALNGDPmrLQQVISNLLSNAIKFTDT-GCI 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 227 WVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQE-DSHIKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFH 305
Cdd:PRK10841 584 VLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGvQRNFQGTGLGLAICEKLINMMDGDISVDSE-PGMGSQFT 662
|
....
gi 1176209583 306 IVLP 309
Cdd:PRK10841 663 IRIP 666
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-309 |
4.73e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 47.67 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFY-----RQHQEdshikGSGLGLFI 279
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgengRNFQE-----STGMGLYL 80
|
90 100 110
....*....|....*....|....*....|
gi 1176209583 280 ARALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:cd16948 81 VKKLCDKLGHKIDVESE-VGEGTTFTITFP 109
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
208-309 |
5.63e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 47.53 E-value: 5.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 208 VLRNLLENAV----LYSDPPAQIWVELN-GEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQedshiKGSGLGLFIARA 282
Cdd:cd16944 8 VLTNILKNAAeaieGRPSDVGEVRIRVEaDQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRP-----KGTGLGLAIVKK 82
|
90 100
....*....|....*....|....*..
gi 1176209583 283 LIKRHKGKITLhSDGTQQGTTFHIVLP 309
Cdd:cd16944 83 IMEEHGGRISL-SNREAGGACIRIILP 108
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
203-293 |
1.00e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 46.69 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 203 DSLTMVLRNLLENAVLYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHQEDSHIKGSGLGLFIARA 282
Cdd:cd16975 3 LLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIAKN 82
|
90
....*....|.
gi 1176209583 283 LIKRHKGKITL 293
Cdd:cd16975 83 LVEKHGGSLII 93
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
166-309 |
1.03e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.90 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 166 NLSQFLNDYLDQWGNSQADDTI-LTRAIDNnvfARIEPD---SLTMVLRNLLENAVLY---SDPPAQIWVELNGEQGRCN 238
Cdd:COG3920 360 DLRDYLRELLEPLRDSYGGRGIrIELDGPD---VELPADaavPLGLILNELVTNALKHaflSGEGGRIRVSWRREDGRLR 436
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176209583 239 LLIRDKGRGIPlseqhkvfrlfyrqhQEDSHIKGSGLGLFIARALIKRHKGKITLHSDgtqQGTTFHIVLP 309
Cdd:COG3920 437 LTVSDNGVGLP---------------EDVDPPARKGLGLRLIRALVRQLGGTLELDRP---EGTRVRITFP 489
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
82-309 |
1.60e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 49.55 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 82 RRQLAlNRE-QKNFIAQ------VTHELKSPVASIQLHLETIKRHHPETQQLDSfVATMLTDTERLTSLINKLLTANRLE 154
Cdd:PRK10618 435 KLQQA-QREyEKNQQARkaflqnIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE-LDQLAEQSDVLVRLVDNIQLLNMLE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 155 QTRWRLALRPHNLSQFLNDYL-------DQWGnsqaddtiLTRAIDNNVFARIE----PDSLTMVLRNLLENAVLYSDPp 223
Cdd:PRK10618 513 TQDWKPEQELFSLQDLIDEVLpevlpaiKRKG--------LQLLIHNHLKAEQLrigdRDALRKILLLLLNYAITTTAY- 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 224 AQIWVELNGEQGRCNLL---IRDKGRGIPLSEQHKVFRLFYRQHQEDSHIKGSGLGLFIARALIKRHKGKITLHS-DGTq 299
Cdd:PRK10618 584 GKITLEVDQDESSPDRLtirILDTGAGVSIKELDNLHFPFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSrEGL- 662
|
250
....*....|
gi 1176209583 300 qGTTFHIVLP 309
Cdd:PRK10618 663 -GTRYSIHLK 671
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
205-309 |
3.72e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 48.37 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAV--LYSDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFrlfyrqhQEDSHIKGS--GLGLFIA 280
Cdd:PRK11086 434 LITILGNLIENALeaVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIF-------DKGYSTKGSnrGVGLYLV 506
|
90 100
....*....|....*....|....*....
gi 1176209583 281 RALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:PRK11086 507 KQSVENLGGSIAVESE-PGVGTQFFVQIP 534
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-309 |
1.01e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 43.93 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYSDPP---------AQIWVELNGEQGR--CNLLIRDKGRGIPLSEQHKVFRLFYrqhqeDSHIKGS 273
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrtrTQRQVTLGHPRHRlaLRVSVIDNGPGIPPDLQDTIFYPMV-----SGRENGT 75
|
90 100 110
....*....|....*....|....*....|....*..
gi 1176209583 274 GLGLFIARALIKRHKGKITLHSdgtQQG-TTFHIVLP 309
Cdd:cd16918 76 GLGLAIAQNIVSQHGGVIECDS---QPGhTVFSVSLP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
241-309 |
1.68e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 43.15 E-value: 1.68e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176209583 241 IRDKGRGIPLSEQHKVFRLFYRQHQEdshikGSGLGLFIARALIKRHKGKITLHSDGTqQGTTFHIVLP 309
Cdd:cd16920 42 VKDTGPGIAEEVAGQLFDPFYTTKSE-----GLGMGLSICRSIIEAHGGRLSVESPAG-GGATFQFTLP 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
239-309 |
4.79e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 41.98 E-value: 4.79e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1176209583 239 LLIRDKGRGIPLSEQHKVFRLFYRQHQEDshiKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFFTTKEVG---KGTGLGLSMVYGFVKQSGGHLRIYSE-PGVGTTVRIYLP 116
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
200-309 |
6.59e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 43.92 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 200 IEPDSLTMVLRNLLENAvlysdppAQIWVELNGE-------------QG-RCNLLIR----DKGRGIPLSEQHKvfrLFY 261
Cdd:PRK11073 233 HDPDQIEQVLLNIVRNA-------LQALGPEGGTitlrtrtafqltlHGeRYRLAARidieDNGPGIPPHLQDT---LFY 302
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1176209583 262 RQhqEDSHIKGSGLGLFIARALIKRHKGKITLHS-DGTqqgTTFHIVLP 309
Cdd:PRK11073 303 PM--VSGREGGTGLGLSIARNLIDQHSGKIEFTSwPGH---TEFSVYLP 346
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
205-313 |
9.87e-05 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 43.85 E-value: 9.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLY----SDPPAQIWVELNGEQGRCNLLIRDKGRGIPLSEQHKVFRLFYRQHqedshiKGSGLGLFIA 280
Cdd:COG2972 337 PKLILQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKG------EGRGIGLRNV 410
|
90 100 110
....*....|....*....|....*....|....*.
gi 1176209583 281 RALIKRHKGK---ITLHSDGtQQGTTFHIVLPRIDE 313
Cdd:COG2972 411 RERLKLYYGEeygLEIESEP-GEGTTVTIRIPLEEE 445
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
88-309 |
1.49e-04 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 43.36 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 88 NREQKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVAtmLTDT-ERLTSLINKLLTANRLEQTRWRLAL--RP 164
Cdd:PRK11466 441 SQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRA--ITDSgESLLTILNDILDYSAIEAGGKNVSVsdEP 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 165 HNLSQFLNDYLD-QWGNSQADDTILTRAIDNNVFARI--EPDSLTMVLRNLLENAVLYSDPpAQIWVELNGEQGRCNLLI 241
Cdd:PRK11466 519 FEPRPLLESTLQlMSGRVKGRPIRLATDIADDLPTALmgDPRRIRQVITNLLSNALRFTDE-GSIVLRSRTDGEQWLVEV 597
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1176209583 242 RDKGRGIPLSEQHKVFRLFYrqhQEDSHIKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLP 309
Cdd:PRK11466 598 EDSGCGIDPAKLAEIFQPFV---QVSGKRGGTGLGLTISSRLAQAMGGELSATST-PEVGSCFCLRLP 661
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
157-283 |
2.25e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 157 RWRLALRPHNLS---QFLNDYLDQWGnsqADDTILTRaidnnvfariepdsLTMVLRNLLENAVLYS---DPPAQIWVEL 230
Cdd:COG2172 1 SLSLPADLEDLGlarRAVRALLRELG---LDEDDADD--------------LVLAVSEAVTNAVRHAyggDPDGPVEVEL 63
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1176209583 231 NGEQGRCNLLIRDKGRGIPLSEqhkvfrlfYRQHQEDShiKGSGLGLFIARAL 283
Cdd:COG2172 64 ELDPDGLEIEVRDEGPGFDPED--------LPDPYSTL--AEGGRGLFLIRRL 106
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
208-292 |
4.43e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 41.54 E-value: 4.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 208 VLRNLLENAVLYSDPpaqiWVELNGEQG--RCNLLIRDKGRGIPLSEQHKVFRlfyRQHQEDSHIKGSGLGLFIARALIK 285
Cdd:PRK10815 382 VMGNVLDNACKYCLE----FVEISARQTdeHLHIVVEDDGPGIPESKRELIFD---RGQRADTLRPGQGLGLSVAREITE 454
|
....*..
gi 1176209583 286 RHKGKIT 292
Cdd:PRK10815 455 QYEGKIS 461
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
201-311 |
1.12e-03 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 40.82 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 201 EPDSLTMVLRNLLENAVLYSDPPAQIWVEL------------NGEQ--GRCNLL-IRDKGRGIPLSEQHKVFRLFYrqhq 265
Cdd:PRK13837 557 NPAELQQVLMNLCSNAAQAMDGAGRVDISLsraklrapkvlsHGVLppGRYVLLrVSDTGAGIDEAVLPHIFEPFF---- 632
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1176209583 266 eDSHIKGSGLGLFIARALIKRHKGKITLHSDgTQQGTTFHIVLPRI 311
Cdd:PRK13837 633 -TTRAGGTGLGLATVHGIVSAHAGYIDVQST-VGRGTRFDVYLPPS 676
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
205-309 |
1.27e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 38.17 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 205 LTMVLRNLLENAVLYS-DPPAQIWVELNGEQG--RCNLLIRDKGRGIPlseqhkvfrlfyrqHQEDSHIKGSgLGLFIAR 281
Cdd:cd16951 40 IGLVVNELLQNALKHAfSDREGGTITIRSVVDgdYLRITVIDDGVGLP--------------QDEDWPNKGS-LGLQIVR 104
|
90 100
....*....|....*....|....*...
gi 1176209583 282 ALIKrHKGKITLHSDGTQQGTTFHIVLP 309
Cdd:cd16951 105 SLVE-GELKAFLEVQSAENGTRVNIDIP 131
|
|
| PRK12705 |
PRK12705 |
hypothetical protein; Provisional |
57-169 |
1.89e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 237178 [Multi-domain] Cd Length: 508 Bit Score: 39.69 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 57 WIILVegILLLIVILVGVYVIFIYWRRQLALNREQKNFIAQVTHELKSPVASIQLHLETIKRHHPETQQLDSFVATMLTD 136
Cdd:PRK12705 5 ILLVI--LLLLIGLLLGVLVVLLKKRQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQRE 82
|
90 100 110
....*....|....*....|....*....|....
gi 1176209583 137 TERLTSLINKLLT-ANRLEQTRWRLALRPHNLSQ 169
Cdd:PRK12705 83 EERLVQKEEQLDArAEKLDNLENQLEEREKALSA 116
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
207-309 |
3.87e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.99 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176209583 207 MVLRNLLENAVLYSdPPAQIWVELNGEQGRCNLLIRDKGRGIplseqhkvfrlfyrqhQEDSHIKGSGLGLFIARALIKR 286
Cdd:cd16917 3 RIVQEALTNALKHA-GASRVRVTLSYTADELTLTVVDDGVGF----------------DGPAPPGGGGFGLLGMRERAEL 65
|
90 100
....*....|....*....|...
gi 1176209583 287 HKGKITLHSdGTQQGTTFHIVLP 309
Cdd:cd16917 66 LGGTLTIGS-RPGGGTRVTARLP 87
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
212-283 |
7.20e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 35.32 E-value: 7.20e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1176209583 212 LLENAVLY---SDPPAQIWVELNGEQGRCNLLIRDKGRGIPLseqhkvfrlfyRQHQE-DSHIKGSGLGLFIARAL 283
Cdd:cd16936 8 AVTNAVRHayrHDGPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADpDAGLREGGRGLALIRAL 72
|
|
| |
