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Conserved domains on  [gi|1176773522|gb|OQY91398|]
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MAG: hypothetical protein B6D38_01980 [Anaerolineae bacterium UTCFX1]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 12-295 1.72e-95

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 283.54  E-value: 1.72e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  12 LSEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSAVDImrdsnGRALTFASPATHSPLGTDDAGHDIWALLIYGAR 91
Cdd:COG1173     5 WRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----DLAARLQPPSAAHWLGTDQLGRDVLSRLLYGAR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  92 ISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQmdlkvsPLSVLILVIGLLYW 171
Cdd:COG1173    80 ISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGP------GLLNVILALGLTGW 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 172 TSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLG-DPTQPSWGT 250
Cdd:COG1173   154 PGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGvQPPTPSWGT 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1176773522 251 MLNFAfsRSAISNgAWWFYLPPGIAILWVSLGCILLGNVLEEMMN 295
Cdd:COG1173   234 MLSEG--RNYLLT-APWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 12-295 1.72e-95

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 283.54  E-value: 1.72e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  12 LSEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSAVDImrdsnGRALTFASPATHSPLGTDDAGHDIWALLIYGAR 91
Cdd:COG1173     5 WRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----DLAARLQPPSAAHWLGTDQLGRDVLSRLLYGAR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  92 ISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQmdlkvsPLSVLILVIGLLYW 171
Cdd:COG1173    80 ISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGP------GLLNVILALGLTGW 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 172 TSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLG-DPTQPSWGT 250
Cdd:COG1173   154 PGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGvQPPTPSWGT 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1176773522 251 MLNFAfsRSAISNgAWWFYLPPGIAILWVSLGCILLGNVLEEMMN 295
Cdd:COG1173   234 MLSEG--RNYLLT-APWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
12-298 1.29e-49

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 167.27  E-value: 1.29e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  12 LSEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSAVDIMRDSNGRALTFASPATHS-PLGTDDAGHDIWALLIYGA 90
Cdd:PRK10913   19 LQEFWHYFKRNKGAVVGLVYVVIMLFIAIFANWIAPHNPAEQFRDALLAPPVWQEGGSWAhILGTDDVGRDVLSRLMYGA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  91 RISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQMDLKVSplsvliLVIGLLY 170
Cdd:PRK10913   99 RLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVNAA------LALTFVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 171 WTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQ-LMPLIVTNTvLILSTAILIESGLAFLGLG-DPTQPSW 248
Cdd:PRK10913  173 LPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNcLAPLIVQAS-LGFSNAILDMAALGFLGMGaQPPTPEW 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1176773522 249 GTMLN--FAFSRSaisngAWWFYLPPGIAILWVSLGCILLGNVLEEMMNPRL 298
Cdd:PRK10913  252 GTMLSdvLQFAQS-----AWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKL 298
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-261 1.91e-19

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 84.25  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  90 ARISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQM--DLKVSPLSVLILVIG 167
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLlgWGILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 168 LLYWTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGDPTQPS 247
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170
                  ....*....|....
gi 1176773522 248 WGTMLNFAFSRSAI 261
Cdd:cd06261   161 TGLLLIFAILFPGD 174
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 108-261 1.44e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 73.49  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 108 GSSLGIIAG-YFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQMDLKVSPLSVLILVIglLYWTSAARLIRSQTLTIK 186
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILAL--LGWAGYARLIRRAALRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 187 ERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGDP-----TQPSWGTMLNFAFSRSAI 261
Cdd:pfam00528  79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGlglllIEAILGYDYPEIQGPVLA 158
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 12-295 1.72e-95

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 283.54  E-value: 1.72e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  12 LSEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSAVDImrdsnGRALTFASPATHSPLGTDDAGHDIWALLIYGAR 91
Cdd:COG1173     5 WRRAWRRLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQ-----DLAARLQPPSAAHWLGTDQLGRDVLSRLLYGAR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  92 ISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQmdlkvsPLSVLILVIGLLYW 171
Cdd:COG1173    80 ISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGP------GLLNVILALGLTGW 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 172 TSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLG-DPTQPSWGT 250
Cdd:COG1173   154 PGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGvQPPTPSWGT 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1176773522 251 MLNFAfsRSAISNgAWWFYLPPGIAILWVSLGCILLGNVLEEMMN 295
Cdd:COG1173   234 MLSEG--RNYLLT-APWLALFPGLAIVLTVLAFNLLGDGLRDALD 275
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
12-298 1.29e-49

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 167.27  E-value: 1.29e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  12 LSEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSAVDIMRDSNGRALTFASPATHS-PLGTDDAGHDIWALLIYGA 90
Cdd:PRK10913   19 LQEFWHYFKRNKGAVVGLVYVVIMLFIAIFANWIAPHNPAEQFRDALLAPPVWQEGGSWAhILGTDDVGRDVLSRLMYGA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  91 RISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQMDLKVSplsvliLVIGLLY 170
Cdd:PRK10913   99 RLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIVNAA------LALTFVA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 171 WTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQ-LMPLIVTNTvLILSTAILIESGLAFLGLG-DPTQPSW 248
Cdd:PRK10913  173 LPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNcLAPLIVQAS-LGFSNAILDMAALGFLGMGaQPPTPEW 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1176773522 249 GTMLN--FAFSRSaisngAWWFYLPPGIAILWVSLGCILLGNVLEEMMNPRL 298
Cdd:PRK10913  252 GTMLSdvLQFAQS-----AWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKL 298
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
15-298 3.16e-48

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 163.45  E-value: 3.16e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  15 FWKaFRRNKLGLVGGFLILTALLAAIFAPALTPHsavdimrDSNGRALT--FASPATHSPLGTDDAGHDIWALLIYGARI 92
Cdd:PRK09881   24 VWM-LKGSPLTVTGAVIIVLMLLMMIFSPWLATH-------DPNAIDLTarLLPPSAAHWFGTDEVGRDLFSRVLVGSQQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  93 SLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRqmdlkvSPLSVLILVIGLLYWT 172
Cdd:PRK09881   96 SILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLSIPSLVLTMALAAALG------PSLFNAMLAIAIVRIP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 173 SAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGdPTQPS--WGT 250
Cdd:PRK09881  170 FYVRLARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDIGSAILMAATLGFIGLG-AQQPSaeWGA 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1176773522 251 MLnfAFSRSAISNgAWWFYLPPGIAILWVSLGCILLGNVLEEMMNPRL 298
Cdd:PRK09881  249 MV--ANGRNYVLD-QWWYCAFPGAAILLTAVGFNLFGDGIRDLLDPKA 293
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 13-298 1.54e-46

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 159.12  E-value: 1.54e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  13 SEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSAVDIMrdsNGRALTFASPATHSpLGTDDAGHDIWALLIYGARI 92
Cdd:PRK15082   26 HEFWRRFRRQHVALVAGLFVLLLIVVAIFAPWIAPYDAENYF---DYDALNAGPSLQHW-FGVDSLGRDIFSRILVGARI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  93 SLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRqmdlkvSPLSVLILVIGLLYWT 172
Cdd:PRK15082  102 SLAAGFFSVAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVAILG------SGMANVIIAVAIFSIP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 173 SAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLG-DPTQPSWGTM 251
Cdd:PRK15082  176 AFARLVRGNTLVLKQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAASLSFLGLGaQPPTPEWGAM 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1176773522 252 LNFAFSRSAISNGAWWFylpPGIAILWVSLGCILLGNVLEEMMNPRL 298
Cdd:PRK15082  256 LNEARADMVIAPHVALF---PSLAIFLTVLAFNLLGDGLRDALDPKI 299
nikC PRK10417
nickel transporter permease NikC; Provisional
 20-302 5.84e-39

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 138.65  E-value: 5.84e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  20 RRNKLGLVGGFLILTALLAAIFAPALTPHS--AVDIMRdsngralTFASPATHSPLGTDDAGHDIWALLIYGARISLMVG 97
Cdd:PRK10417    1 SSRWSVRLALIIIALLALIALTSQWWLPYDpqAIDLPS-------RLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  98 FLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRqmdlkvSPLSVLILVIGLLYWTSAARL 177
Cdd:PRK10417   74 MACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFPTSILAFFMVGVLG------TGLTNVIIAIALSHWAWYARM 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 178 IRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLG-DPTQPSWGTMLNFA- 255
Cdd:PRK10417  148 VRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATLDIGHMMLHVAGLSFLGLGvTAPTAEWGVMINDAr 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1176773522 256 -FSRSAISNGAWwfylpPGIAILWVSLGCILLGNVLEEMMNPRLTAHY 302
Cdd:PRK10417  228 qYIWTQPLLMFW-----PGLALFISVMAFNLLGDALRDHLDPHLVTEH 270
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 19-297 7.98e-35

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 128.42  E-value: 7.98e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  19 FRRNKLGLVGGFLILTALLAAIFAPALTPHSavdimRDSNGRALTFASPATHSP--LGTDDAGHDIWALLIYGARISLMV 96
Cdd:PRK15406   33 FMHNRAAVASLIVLVLIALFVILAPMLSQFA-----YDDTDWGMMSSAPDMESGhyFGTDSSGRDLLVRVAIGGRISLMV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  97 GFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQMDLkvsplsVLILVIGLLYWTSAAR 176
Cdd:PRK15406  108 GVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFGQNIL------LIFVAIGMVSWLDMAR 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 177 LIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGdpTQ---PSWGTMLN 253
Cdd:PRK15406  182 IVRGQTLSLKRKEFIEAAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLG--TQeplSSWGALLS 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1176773522 254 FAFSRSAISngAWWFYLPPGiaILWVSLGCI-LLGNVLEEMMNPR 297
Cdd:PRK15406  260 DGANSMEVS--PWLLLFPAG--FLVVTLFCFnFIGDGLRDALDPK 300
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 65-253 3.06e-34

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 127.57  E-value: 3.06e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  65 ASPATHSPLGTDDAGHDIWALLIYGARISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLV 144
Cdd:COG4239   115 SPPSAENWLGTDDQGRDVLARLIYGFRISVLFGLALTVISSVIGVAAGAVQGYFGGRVDLLFQRFIEIWSSMPELYLLII 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 145 LVATIrqmdlkVSPLSVLILVIGLLYWTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLI 224
Cdd:COG4239   195 LSSIF------QPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRIMFRHILPNAMVATLTFLPFI 268

                         170       180       190
                  ....*....|....*....|....*....|
gi 1176773522 225 LSTAILIESGLAFLGLG-DPTQPSWGTMLN 253
Cdd:COG4239   269 LSGAITTLTSLDFLGFGlPPGSPSLGELLA 298
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 65-252 7.98e-21

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 91.20  E-value: 7.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  65 ASPATHSPLGTDDAGHDIWALLIYGARISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLV 144
Cdd:PRK15021  115 SPPSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIIL 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 145 LVATirqmdlkVSPLSVLILVIGLLY-WTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVL 223
Cdd:PRK15021  195 LSSV-------VQPNFWWLLAITVLFgWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPF 267

                         170       180       190
                  ....*....|....*....|....*....|
gi 1176773522 224 ILSTAILIESGLAFLGLGDPT-QPSWGTML 252
Cdd:PRK15021  268 ILCSSITTLTSLDFLGFGLPLgSPSLGELL 297
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 90-261 1.91e-19

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 84.25  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  90 ARISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQM--DLKVSPLSVLILVIG 167
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLlgWGILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 168 LLYWTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGDPTQPS 247
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170
                  ....*....|....
gi 1176773522 248 WGTMLNFAFSRSAI 261
Cdd:cd06261   161 TGLLLIFAILFPGD 174
PRK15111 PRK15111
peptide ABC transporter permease SapC;
16-295 2.20e-17

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 80.90  E-value: 2.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  16 WKAFRRNKLGLVGGFLILTALLAAIFAPALTPHSavdIMRDSNGRALTFASPATHSP----LGTDDAGHDIWALLIYGAR 91
Cdd:PRK15111   20 WRKFYSDALAMVGLYGCAGLALLCLFGGWLAPYG---IDQQFLGYQLLPPSWSRYGEvsffLGTDDLGRDVLSRLLSGAA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  92 ISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRqmdlkvSPLSVLILVIGLLYW 171
Cdd:PRK15111   97 PTVGGAFVVTLAATLCGLVLGVFAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAG------PSLSHAMFAVWLALL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 172 TSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGD--PTqPSWG 249
Cdd:PRK15111  171 PRMVRSIYSAVHDELEKEYVIAARLDGASTLNILWYAVLPNITAGLVTEITRALSMAILDIAALGFLDLGAqlPS-PEWG 249

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1176773522 250 TMLNFAFSrsaISNGAWWFYLPPGIAILWVSLGCILLGNVLEEMMN 295
Cdd:PRK15111  250 AMLGDSLE---LIYVAPWTVMLPGAAIMLSVLLVNLLGDGIRRAII 292
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 108-261 1.44e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 73.49  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 108 GSSLGIIAG-YFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQMDLKVSPLSVLILVIglLYWTSAARLIRSQTLTIK 186
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILAL--LGWAGYARLIRRAALRSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 187 ERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNTVLILSTAILIESGLAFLGLGDP-----TQPSWGTMLNFAFSRSAI 261
Cdd:pfam00528  79 PSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGlglllIEAILGYDYPEIQGPVLA 158
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 79-241 4.11e-10

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 59.70  E-value: 4.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  79 GHDIWALLIYGARISLMVGFLAGFISMFVGSSLGIIAGYF-GGAVDTLVMRVTDILMVIPD--LPLMLVLVATIR----- 150
Cdd:COG0601    84 GRPVSDLIAERLPVTLELALLALLLALLIGIPLGILAALRrGSWLDRLITVLALLGISIPSfwLGLLLILLFAVKlgwlp 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 151 ---QMDLKVSPLSVL------ILVIGLLYWTSAARLIRSQTLTIKERQFVARARAIGAGHWHIIRKHILPQLMPLIVTNT 221
Cdd:COG0601   164 vsgRVSPWEDFLDALrhlilpALTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVVTVL 243

                         170       180
                  ....*....|....*....|....
gi 1176773522 222 VLILST----AILIESGLAFLGLG 241
Cdd:COG0601   244 GLQLGGllggAVVVETVFSWPGLG 267
OppC_N pfam12911
N-terminal TM domain of oligopeptide transport permease C; Oligopeptide permeases (Opp) have ...
 12-49 1.83e-06

N-terminal TM domain of oligopeptide transport permease C; Oligopeptide permeases (Opp) have been identified in numerous gram-negative and -positive bacteria. These transport systems belong to the superfamily of highly conserved ATP-binding cassette transporters. Typically, Opp importers comprise a complex of five proteins. The oligopeptide-binding protein OppA is responsible for the capture of peptides from the external medium. Two integral highly hydrophobic membrane spanning proteins, OppB and OppC, form a channel through the membrane used for peptide translocation. This N-terminal domain appears to be the first TM domain of the molecule.


Pssm-ID: 463747 [Multi-domain]  Cd Length: 53  Bit Score: 44.33  E-value: 1.83e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1176773522  12 LSEFWKAFRRNKLGLVGGFLILTALLAAIFAPALTPHS 49
Cdd:pfam12911   3 WQDAWRRFRRNKLAMVGLVILLLLVLLAIFAPLLAPYD 40
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 81-225 7.39e-05

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 43.14  E-value: 7.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522  81 DIWALLIYGARISLMVGFLAGFISMFVGSSLGIIAGYFGGAVDTLVMRVTDILMVIPDLPLMLVLVATIRQMDLKVSPLS 160
Cdd:COG0765    10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSPFV 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176773522 161 VLILVIGLlyWTSA--ARLIRSQTLTIKERQFVArARAIGAGHWHIIRKHILPQLMPLIV---TNTVLIL 225
Cdd:COG0765    90 AAVIALTL--NSAAylAEIVRAGIQSVPKGQWEA-ARALGLSRWQTMRRIILPQALRIILpplGNEFISL 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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